CN105641202A - Pharmaceutical composition for treating appendicitis and preparation method thereof - Google Patents

Pharmaceutical composition for treating appendicitis and preparation method thereof Download PDF

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CN105641202A
CN105641202A CN201610047030.7A CN201610047030A CN105641202A CN 105641202 A CN105641202 A CN 105641202A CN 201610047030 A CN201610047030 A CN 201610047030A CN 105641202 A CN105641202 A CN 105641202A
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herba
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ethanol
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不公告发明人
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Jinan Xingyi Medical Technology Co Ltd
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Abstract

The invention discloses a pharmaceutical composition for treating appendicitis and a preparation method thereof. The pharmaceutical composition is prepared by taking bitter herb, stems and leaves of procris wightiana Wall. ex Wedd., herb of solanum nigrum L., herba taraxaci, fructus aurantii, mung beans, herba patriniae, roots of solanum torvum swartz, taraxerol and anonaine as bulk pharmaceuticals in proportion and can be prepared into various dosage forms according to a conventional preparation technology, and the appendicitis treatment effect is significant.

Description

One treats typhlitic pharmaceutical composition and preparation method thereof
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to one and treat typhlitic pharmaceutical composition and preparation method thereof.
Background technology
Appendicitis (Appendicitis) refers to that the inflammatory that vermiform appendix is formed due to many factors changes. It is a kind of commonly encountered diseases, and its prognosis depends on whether to diagnose and treat timely. If delay diagnosis and treatment can cause serious complication, even cause death. Appendicitis is a kind of commonly encountered diseases. Often there are the performances such as the rising of right lower abdomen pain, body temperature, vomiting and neutrophilic leukocytosis clinically. Appendicitis is the inflammation of vermiform appendix, modal Abdominal Surgery. Vermiform appendix empties the not good enough one of the main reasons being appendicitis and occurring. Mainly due to the blind pipe of bending, opening is tiny, and tube chamber is narrow again, and it is extremely slow to wriggle, so that vermiform appendix tube chamber very easily blocks, often because excrement block (stone), food kibble, ascarid or foreign body block.
The typical clinical manifestations of acute appendicitis is dull pain around the epigastrium or umbilicus that occur gradually, and after a few hours, stomachache is transferred to right lower abdomen. Be often accompanied by inappetence, n or V, their early stage except low grade fever, weak except, how without obvious General Symptoms. If acute appendicitis is early treatment not, it is possible to develop into vermiform appendix gangrene and perforation, concurrently limit office or general peritonitis. Acute appendicitis has the mortality rate of less than 1%, and it is 5��10% that the mortality rate after general peritonitis occurs. Acute appendicitis through non-operative treatment or cure after, it is possible to leave over appendiceal wall proliferation of fibrous tissue and thicken, luminal stenosis and surrounding adhesion, this is called chronic appendicitis, is easily caused acute attack again. Attack times is more many, and the infringement of chronic inflammatory disease is also more serious, it is possible to acute attack repeatedly, does not have symptom when not showing effect or occasionally has slight Right Lower Abdomen pain, so also referred to as chronic recurrent appendicitis. Appendicitis can occur at any age, but with person between twenty and fifty for common, 20-30 year is onset peak.
Existing Appendicitis Patients, except operative treatment, generally individually employing expectant treatment: lie up, take semireclining position, semi-fluid or liquid diet. Drug therapy, broad ectrum antibiotic cephalosporins ampicillin of selecting, or quinolone antibiotic more, such as ofloxacin etc., and add with metronidazole etc. But these effects are not of great satisfaction.
Herba Sonchi Oleracei: Compositae open country gutweed platymiscium Herba Ixeritis chinensis Ixerischinensis(Thunb.) Nakai, with all herbal medicine. The spring and summer autumn all can gather, and dries. [nature and flavor] are bitter, cold. [function cures mainly] heat-clearing and toxic substances removing, removing blood stasis with potent drugs is invigorated blood circulation, evacuation of pus. For appendicitis, peritoneal abscess, enteritis, dysentery, acute and chronic pelvic inflammatory disease, cough due to lung-heat, pulmonary tuberculosis, spit blood, epistaxis; Traumatic injury is controlled in external, and furuncle swells and ache, impetigo, eczema scrotum.[extracts] " whole nation Chinese herbal medicine compilation ".
Eyes grass: Urticaceae eyes grass ProcriswightianaWall.exWedd., dries with stem, leaf and is used as medicine. [nature and flavor] micro-hardship, acid, cool. [function cures mainly] heat-clearing and toxic substances removing, removing nebula to improve visual acuity. [extracts] " whole nation Chinese herbal medicine compilation ".
Herba Solani Nigri: for Solanaceae nightshade Herba Solani Nigri SolanumnigrumL., with all herbal medicine. Xia Qiu gathers, and dries. [nature and flavor] are bitter, cold. Slightly poisonous. [function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema. For cat fever, toothache, chronic bronchitis, dysentery, urinary system infection, mastitis, leucorrhea, cancer; Carbuncle furuncle furuncle, pemphigus, venom are controlled in external. [extracts] " whole nation Chinese herbal medicine compilation ".
Herba Taraxaci: this product is feverfew Herba Taraxaci TaraxacummongolicumHand.-Mazz., alkali ground Herba Taraxaci TaraxacumsinicumKitag. or the dry herb belonging to several plants together. Spend spring to autumn and excavate when just opening, remove impurity, clean, dry. [character] this product is the curling agglomerate of shrinkage. Root is conical, bends more, long 3��7cm; Surface sepia, shirring; Root head has the fine hair of sepia or yellow-white, and what have comes off. Phyllopodium is raw, and many shrinkages crush, and intact leaf is in falling lanceolar, green and brown color or lead, and tip is sharp or blunt, and edge is shallow to be split or pinnation, and base portion is gradually narrow, and downward in handle, lower surface master pulse is obvious. Scape 1 is to several, and every top repiece locusta, phyllary multilamellar, inner face one layer is longer, corolla yellowish-brown or yellowish white. The oblong achene of the visible most tool white pappus having. Feeble QI, mildly bitter flavor. [nature and flavor] are bitter, sweet, cold. [return through] returns liver, stomach warp. [function cures mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome. For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria. [extracts] " Chinese Pharmacopoeia ".
Fructus Aurantii: this product is the dry immature fruit of rutaceae Citrus aurantium Linn. CitrusaurantiumL. and variety thereof. July peel still green time gather, be two halves from middle part crosscut, dry or cold drying. [character] this product is hemispherical, diameter 3��5cm. Outer peel sepia or brown, have graininess projection, and there is concave point shape grease chamber on the top of projection; There are obvious style vestiges or carpopodium trace. Tangent plane mesocarp yellow-white, smooth and slightly swell, thick 0.4��1.3cm, edge dissipates 1��2 row grease chamber, and pulp 7��12 lobe, minority is to 15 lobes, and juice sac drying shrinkage is brown to sepia, built-in seed. Matter is hard, is not easily broken. Gas delicate fragrance, bitter in the mouth, micro-acid. [nature and flavor] are bitter, pungent, sour, temperature. [return through] returns spleen, stomach warp. [function cures mainly] regulating the flow of QI to ease the stomach, the stagnant relieving distension of row. Coerce the stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion for breast, stop in phlegm retention; Gastroptosis, proctoptosis, sub-official prolapses. [extracts] " Chinese Pharmacopoeia ".
Semen phaseoli radiati: pulse family Phaseolus plant Semen phaseoli radiati PhaseolusradiatusL., is used as medicine with seed. [nature and flavor] are sweet, cold. [return through] enters the heart, stomach warp. [function cures mainly] heat-clearing and toxic substances removing, relieves summer heat. For diseases such as summer-heat excessive thirst, sore carbuncle. Radix Aconiti Lateralis Preparata, Fructus Crotonis poison can be solved. [extracts] " whole nation Chinese herbal medicine compilation ".
Herba Patriniae: this product is Herba Patriniae section plant Hemerocallis citrina Baroni dragon bud PatriniascabiosaefoliaFisch.exLink., patrima villosa (bitter vegetarian) P.villosa(Thunb.) Juss., with root stock and root, all herbal medicine.Root is excavated season in spring and autumn, removes stem and leaf and cleans, dries. Autumn in herb summer taps, and cleans and dries. [nature and flavor] are pungent, bitter, cool. [return through] enters stomach, large intestine, Liver Channel. [function cures mainly] heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt. For acute appendicitis, lung abscess and sore and toxic, the stagnant caused chest and abdomen pain of the excess-heat stasis of blood, puerperal the disease such as the stagnant stomachache of the stasis of blood. [extracts] " whole nation Chinese herbal medicine compilation ".
Radix Solani Torvi: Solanaceae nightshade Radix Solani Torvi SolanumtorvumSwartz, is used as medicine with root. The whole year can adopt, and cleans and dries. [nature and flavor] are pungent, micro-cool. Slightly poisonous. [function cures mainly] dissipating blood stasis, stimulates the menstrual flow, detumescence, pain relieving, cough-relieving. [extracts] " whole nation Chinese herbal medicine compilation ".
Taraxerol (Taraxerol): CAS 127-22-0, molecular formula C30H50O, molecular weight 426.73. [pharmacological action] antiulcer, anti-gastric acid secretion. [ingredient origin] feverfew Europe Radix Taraxaci; Ebenaceae Diospyros plant, Fagaceae platymiscium, Canarium plant.
Anonaine (Anonaine): CAS 1862-41-5, molecular formula C17H15NO2, molecular weight 265.31. [pharmacological action] expelling worm, antibacterial. [ingredient origin] annonaceae plant bullock's-heart, nymphaeaceae plant.
2 crude drug chemical constitutions:
Taraxerol (Taraxerol) anonaine (Anonaine).
Summary of the invention
It is an object of the invention to overcome the deficiency of background technology, it is provided that typhlitic pharmaceutical composition of a kind of effectively treatment and preparation method thereof.
The present invention adopts the following technical scheme that realization:
Composition and the weight portion of making the crude drug of the typhlitic pharmaceutical composition of this treatment be:
Herba Sonchi Oleracei 60-80 weight portion, eyes grass 80-100 weight portion, Herba Solani Nigri 100-130 weight portion, Herba Taraxaci 20-30 weight portion, Fructus Aurantii 10-20 weight portion, Semen phaseoli radiati 10-20 weight portion, Herba Patriniae 80-100 weight portion, Radix Solani Torvi 60-80 weight portion, taraxerol 0.5-0.9 weight portion, anonaine 1-2 weight portion;
It is preferably used in the typhlitic pharmaceutical composition for the treatment of, is prepared by the crude drug composition of weight portion:
Herba Sonchi Oleracei 70 weight portion, eyes grass 90 weight portions, Herba Solani Nigri 110 weight portion, Herba Taraxaci 25 weight portion, Fructus Aurantii 15 weight portion, Semen phaseoli radiati 15 weight portion, Herba Patriniae 90 weight portion, Radix Solani Torvi 70 weight portion, taraxerol 0.7 weight portion, anonaine 1.5 weight portion;
One treats typhlitic pharmaceutical composition, it is characterised in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to prepare into tablet or capsule or drop pill.
One treats typhlitic pharmaceutical composition, it is characterised in that the treatment appendicitis medicine that pharmaceutical composition forms with chemical drugs or Chinese medicine.
A kind of preparation method treating typhlitic pharmaceutical composition, it is characterised in that prepare as follows:
The composition of crude drug and weight portion be: Herba Sonchi Oleracei 60-80 weight portion, eyes grass 80-100 weight portion, Herba Solani Nigri 100-130 weight portion, Herba Taraxaci 20-30 weight portion, Fructus Aurantii 10-20 weight portion, Semen phaseoli radiati 10-20 weight portion, Herba Patriniae 80-100 weight portion, Radix Solani Torvi 60-80 weight portion, taraxerol 0.5-0.9 weight portion, anonaine 1-2 weight portion;
Preparation method:
(1) Herba Sonchi Oleracei, eyes grass, Herba Solani Nigri, Herba Taraxaci, Fructus Aurantii, Semen phaseoli radiati, Herba Patriniae, Radix Solani Torvi are taken by crude drug proportioning, mixing, micronizing is to 80 microns, with weight percent concentration 65% ethanol as solvent, 55 DEG C of warm macerating extract, and extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentration, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 30% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 14 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, it is concentrated into relative density 1.12, filter, medicinal liquid passes through LS300 macroporous adsorptive resins, first wash with water, again with the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 65%, collect weight percent concentration 65% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) taraxerol, anonaine are taken by crude drug proportioning, mixing, it is sequentially added into extract A, extract B, mixing, obtain pharmaceutical composition.
Preferably a kind of preparation method treating typhlitic pharmaceutical composition, it is characterised in that prepare as follows:
The composition of crude drug and weight portion be: Herba Sonchi Oleracei 70 weight portion, eyes grass 90 weight portions, Herba Solani Nigri 110 weight portion, Herba Taraxaci 25 weight portion, Fructus Aurantii 15 weight portion, Semen phaseoli radiati 15 weight portion, Herba Patriniae 90 weight portion, Radix Solani Torvi 70 weight portion, taraxerol 0.7 weight portion, anonaine 1.5 weight portion;
Preparation method:
(1) Herba Sonchi Oleracei, eyes grass, Herba Solani Nigri, Herba Taraxaci, Fructus Aurantii, Semen phaseoli radiati, Herba Patriniae, Radix Solani Torvi are taken by crude drug proportioning, mixing, micronizing is to 80 microns, with weight percent concentration 65% ethanol as solvent, 55 DEG C of warm macerating extract, and extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentration, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 30% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 14 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, it is concentrated into relative density 1.12, filter, medicinal liquid passes through LS300 macroporous adsorptive resins, first wash with water, again with the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 65%, collect weight percent concentration 65% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) taraxerol, anonaine are taken by crude drug proportioning, mixing, it is sequentially added into extract A, extract B, mixing, obtain pharmaceutical composition.
A kind of preparation method treating typhlitic pharmaceutical composition, it is characterised in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to prepare into tablet or capsule or drop pill.
A kind of preparation method treating typhlitic pharmaceutical composition, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine composition treatment appendicitis medicine.
Detailed description of the invention
Embodiment 1: treat typhlitic pharmaceutical composition and preparation method thereof
Composition and the weight portion for the treatment of the crude drug of typhlitic pharmaceutical composition be:
Herba Sonchi Oleracei 70 weight portion, eyes grass 90 weight portions, Herba Solani Nigri 110 weight portion, Herba Taraxaci 25 weight portion, Fructus Aurantii 15 weight portion, Semen phaseoli radiati 15 weight portion, Herba Patriniae 90 weight portion, Radix Solani Torvi 70 weight portion, taraxerol 0.7 weight portion, anonaine 1.5 weight portion;
Preparation method:
(1) Herba Sonchi Oleracei, eyes grass, Herba Solani Nigri, Herba Taraxaci, Fructus Aurantii, Semen phaseoli radiati, Herba Patriniae, Radix Solani Torvi are taken by crude drug proportioning, mixing, micronizing is to 80 microns, with weight percent concentration 65% ethanol as solvent, 55 DEG C of warm macerating extract, and extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentration, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 30% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 14 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, it is concentrated into relative density 1.12, filter, medicinal liquid passes through LS300 macroporous adsorptive resins, first wash with water, again with the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 65%, collect weight percent concentration 65% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) taraxerol, anonaine are taken by crude drug proportioning, mixing, it is sequentially added into extract A, extract B, mixing, obtain pharmaceutical composition.
Embodiment 2: treat typhlitic pharmaceutical composition and preparation method thereof
Composition and the weight portion for the treatment of the crude drug of typhlitic pharmaceutical composition be:
Herba Sonchi Oleracei 60 weight portion, eyes grass 100 weight portions, Herba Solani Nigri 100 weight portion, Herba Taraxaci 30 weight portion, Fructus Aurantii 10 weight portion, Semen phaseoli radiati 20 weight portion, Herba Patriniae 80 weight portion, Radix Solani Torvi 80 weight portion, taraxerol 0.5 weight portion, anonaine 2 weight portion;
Preparation method:
(1) Herba Sonchi Oleracei, eyes grass, Herba Solani Nigri, Herba Taraxaci, Fructus Aurantii, Semen phaseoli radiati, Herba Patriniae, Radix Solani Torvi are taken by crude drug proportioning, mixing, micronizing is to 80 microns, with weight percent concentration 65% ethanol as solvent, 55 DEG C of warm macerating extract, and extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentration, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 30% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 14 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, it is concentrated into relative density 1.12, filter, medicinal liquid passes through LS300 macroporous adsorptive resins, first wash with water, again with the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 65%, collect weight percent concentration 65% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) taraxerol, anonaine are taken by crude drug proportioning, mixing, it is sequentially added into extract A, extract B, mixing, obtain pharmaceutical composition.
Embodiment 3: treat typhlitic pharmaceutical composition and preparation method thereof
Composition and the weight portion for the treatment of the crude drug of typhlitic pharmaceutical composition be:
Herba Sonchi Oleracei 80 weight portion, eyes grass 80 weight portions, Herba Solani Nigri 130 weight portion, Herba Taraxaci 20 weight portion, Fructus Aurantii 20 weight portion, Semen phaseoli radiati 10 weight portion, Herba Patriniae 100 weight portion, Radix Solani Torvi 60 weight portion, taraxerol 0.9 weight portion, anonaine 1 weight portion;
Preparation method:
(1) Herba Sonchi Oleracei, eyes grass, Herba Solani Nigri, Herba Taraxaci, Fructus Aurantii, Semen phaseoli radiati, Herba Patriniae, Radix Solani Torvi are taken by crude drug proportioning, mixing, micronizing is to 80 microns, with weight percent concentration 65% ethanol as solvent, 55 DEG C of warm macerating extract, and extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentration, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 30% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 14 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, it is concentrated into relative density 1.12, filter, medicinal liquid passes through LS300 macroporous adsorptive resins, first wash with water, again with the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 65%, collect weight percent concentration 65% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) taraxerol, anonaine are taken by crude drug proportioning, mixing, it is sequentially added into extract A, extract B, mixing, obtain pharmaceutical composition.
Embodiment 4: the preparation of tablet
Example 1 pharmaceutical composition 145g, adds starch 35g, mixing, granulates, dry, adds microcrystalline Cellulose 20g, magnesium stearate 1.0g, and mixing is pressed into 1000, obtains medicinal composition tablets.
Embodiment 5: the preparation of capsule
Example 2 pharmaceutical composition 145g, adds starch 35g, mixing, granulates, dry, and granulate adds appropriate magnesium stearate, mixing, encapsulated 1000, obtains medicament composition capsule.
Embodiment 6: the preparation of drop pill
Weigh polyethylene glycol 6000 200g water-bath (80 DEG C) heating and boil molten, add embodiment 3 pharmaceutical composition 25g, stir, with liquid paraffin for coolant, put in glass tubing (4*80cm), chilling temperature is 6 DEG C, drip internal-and external diameter is 7.0/2.0 (mm/mm), and drip is 2.5cm from liquid level, drips speed with per minute 50 for optimum condition, blot the condensing agent on drop pill surface with cotton, obtain medicament composition dropping pills.
Embodiment 7: treat typhlitic pharmaceutical composition
Composition and the weight portion for the treatment of the crude drug of typhlitic pharmaceutical composition be:
Semen phaseoli radiati 20 weight portion, Herba Patriniae 120 weight portion, Radix Solani Torvi 60 weight portion, taraxerol 1 weight portion, anonaine 0.6 weight portion.
Embodiment 8: treat typhlitic pharmaceutical composition
Composition and the weight portion for the treatment of the crude drug of typhlitic pharmaceutical composition be:
Bean 30 weight portion, Herba Patriniae 50 weight portion, Radix Solani Torvi 100 weight portion, taraxerol 0.5 weight portion, anonaine 1 weight portion.
Embodiment 9: treat typhlitic pharmaceutical composition
Composition and the weight portion for the treatment of the crude drug of typhlitic pharmaceutical composition be:
Semen phaseoli radiati 10 weight portion, Herba Patriniae 150 weight portion, Radix Solani Torvi 20 weight portion, taraxerol 1.5 weight portion, anonaine 0.2 weight portion.
Experimental example 1: treatment appendicitis experimental study
1 data and method
1.1 physical data select patient 80 example of Center Hospital of Jinan City JIUYUE in 2013 in JIUYUE, 1 2014 appendicitis treatment to be the object of experimentation, wherein have male patient 40 example, have female patient 40 example; Oldest patient has 60 years old, and age minimum patient has l8 year, and patient's mean age is (36.8 �� 8.3) year; What morbidity's time was the longest has 72 hours, and the shortest is 5 hours, and average time is (39.9 �� 4.1) hour; Wherein chronic appendicitis patients 25 example, acute suppurative appendicitis patient has 11 examples, and acute simple appendicitis patient has 44 examples. All patients are all having the aggravation of Right Lower Abdomen pain, paroxysmal and persistence swelling in varying degrees, simultaneously, it is likely to situations such as nausea,vomiting,diarrhea, constipation and neutrophilic granulocyte and blood leukocytes sum increases, difference according to patient treatment medicine is divided into observation group (n=40) and matched group (n=40), two groups of patients all do not have notable difference in sex, age, disease time and the ordinary circumstance such as disease type, clinical manifestation, and between sample, basic condition has comparability (Jp > 0.05).
1.2 Therapeutic Method matched group patients use ofloxacin to treat, and the dosage that Therapeutic Method is oral, each is 1, and every day 2 times, the time taken continuously is 7 days. Observation group patient is applied on treatment of control group basis, adds pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20101112) treatment, every day 3 times, each 2g, continuous oral 7 days.
Two groups carry out curative effect comparation and assessment all after 7 days.
The incidence rate of two groups of patient treatment effective percentage, the symptom improvement untoward reaction such as situation and stomachache, diarrhoea, vomiting and dizziness is all carried out comprehensively record and observation by 1.3 observation index, for experimental analysis. Patient treatment effective percentage situation is analyzed according to " Chinese medical disease Standardization of diagnosis and curative effect " and evaluates: the clinical symptoms such as patient's stomachache are wholly absent, and the hemogram of patient recovers normal for curing; Patients symptomatic and sign are good all to some extent transfers improvement to; It is invalid that patients symptomatic and sign are not improved and are changed to; Effective percentage=cure rate+improvement rate.
In this experimentation of 1.4 statistical analysis, the statistics of data, typing and analysis all adopt SPSS19.0 statistics software to complete, measurement data mean ��, enumeration data compares employing percent (%) and represents and t inspection, and the result that P < 0.05 shows between experimental data evidence has statistical significance.
2 results
There is patient 40 example in observation group, and its treated effect is 95.0%; Matched group has patient 40 example, and its treated effect is 85.0%, and observation group's patient treatment effective percentage is apparently higher than matched group, and difference has statistical significance, and (P < 0.05) refers to table 1.
The therapeutic effect of 1 liang of table group patient compares [example (%)]
Group Number of cases Cure Improve Invalid Effective percentage
Observation group 40 20 18 2 95.0%*
Matched group 40 14 20 6 85.0%
Note: compare with matched group, * P < 0.05.
Experimental example 2: model case
King XX, man, 27 years old, Appendicitis Patients, during December in 2014 afternoon 2 on the 22nd, Right Lower Abdomen pain occurs, generates heat inconspicuous, abdominal part is put down soft, mcBurney point tenderness (+). Auxiliary examination: routine blood test shows total white blood cells 17.9 �� 109/L. Visible leukocyte 2 under routine urinalysis mirror. Abdominal B type ultrasonography is pointed out: visible one 2.5cm of Right Lower Abdomen vermiform appendix �� 1.8cm owes uniform echo on the low side, profile owes rule, border owes clear, it is diagnosed as appendicitis, patient takes this pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20101112) treatment, every day 3 times, each 2g immediately, continuous oral is the transference cure such as pain after 3 days, after continue to take 7 days and thoroughly cure.
Lee XX, female, 40 years old, Appendicitis Patients, fall ill during the August in 2014 of the morning 10 on the 28th, generate heat after 2 hours, rise to 38 degree with PD body temperature--39 degree. Inappetence, nausea and vomiting, Right Lower Abdomen pain. Patient takes this pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20101112) treatment immediately, every day 3 times, each 2g, continuous oral after 7 days the transference cure such as pain thoroughly cure.
Close XX, man, 50 years old, Appendicitis Patients, fall ill during the October in 2014 of afternoon 3 on the 6th, cardinal symptom: stomach discomfort, constipation or laxativeness etc. after inappetence, abdominal distention, food, time be often accompanied by Right Lower Abdomen pain pain and tenderness sense and intermittent recurrent exerbation. Patient takes this pharmaceutical composition (embodiment 1 pharmaceutical composition lot number 20101112) treatment immediately, every day 3 times, each 2g, continuous oral is the transference cure such as pain after 7 days, after continue to take Right Lower Abdomen pain pain and tenderness sense in 10 days completely without, ill symptoms disappears, and livelihood restoration is normal, then does not have intermittent recurrent exerbation.

Claims (8)

1. treat typhlitic pharmaceutical composition for one kind, it is characterised in that composition and the weight portion of making the crude drug of this pharmaceutical composition be:
Herba Sonchi Oleracei 60-80 weight portion, eyes grass 80-100 weight portion, Herba Solani Nigri 100-130 weight portion, Herba Taraxaci 20-30 weight portion, Fructus Aurantii 10-20 weight portion, Semen phaseoli radiati 10-20 weight portion, Herba Patriniae 80-100 weight portion, Radix Solani Torvi 60-80 weight portion, taraxerol 0.5-0.9 weight portion, anonaine 1-2 weight portion.
2. one treats typhlitic pharmaceutical composition according to claim 1, it is characterised in that composition and the weight portion of making the crude drug of this pharmaceutical composition be:
Herba Sonchi Oleracei 70 weight portion, eyes grass 90 weight portions, Herba Solani Nigri 110 weight portion, Herba Taraxaci 25 weight portion, Fructus Aurantii 15 weight portion, Semen phaseoli radiati 15 weight portion, Herba Patriniae 90 weight portion, Radix Solani Torvi 70 weight portion, taraxerol 0.7 weight portion, anonaine 1.5 weight portion.
3. one treats typhlitic pharmaceutical composition according to claim 1, it is characterised in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to prepare into tablet or capsule or drop pill.
4. one treats typhlitic pharmaceutical composition according to claim 1, it is characterised in that the treatment appendicitis medicine that pharmaceutical composition forms with chemical drugs or Chinese medicine.
5. the preparation method treating typhlitic pharmaceutical composition, it is characterised in that prepare as follows:
The composition of crude drug and weight portion be: Herba Sonchi Oleracei 60-80 weight portion, eyes grass 80-100 weight portion, Herba Solani Nigri 100-130 weight portion, Herba Taraxaci 20-30 weight portion, Fructus Aurantii 10-20 weight portion, Semen phaseoli radiati 10-20 weight portion, Herba Patriniae 80-100 weight portion, Radix Solani Torvi 60-80 weight portion, taraxerol 0.5-0.9 weight portion, anonaine 1-2 weight portion;
Preparation method:
(1) Herba Sonchi Oleracei, eyes grass, Herba Solani Nigri, Herba Taraxaci, Fructus Aurantii, Semen phaseoli radiati, Herba Patriniae, Radix Solani Torvi are taken by crude drug proportioning, mixing, micronizing is to 80 microns, with weight percent concentration 65% ethanol as solvent, 55 DEG C of warm macerating extract, and extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentration, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 30% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 14 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, it is concentrated into relative density 1.12, filter, medicinal liquid passes through LS300 macroporous adsorptive resins, first wash with water, again with the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 65%, collect weight percent concentration 65% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) taraxerol, anonaine are taken by crude drug proportioning, mixing, it is sequentially added into extract A, extract B, mixing, obtain pharmaceutical composition.
6. a kind of preparation method treating typhlitic pharmaceutical composition according to claim 5, it is characterised in that prepare as follows:
The composition of crude drug and weight portion be: Herba Sonchi Oleracei 70 weight portion, eyes grass 90 weight portions, Herba Solani Nigri 110 weight portion, Herba Taraxaci 25 weight portion, Fructus Aurantii 15 weight portion, Semen phaseoli radiati 15 weight portion, Herba Patriniae 90 weight portion, Radix Solani Torvi 70 weight portion, taraxerol 0.7 weight portion, anonaine 1.5 weight portion;
Preparation method:
(1) Herba Sonchi Oleracei, eyes grass, Herba Solani Nigri, Herba Taraxaci, Fructus Aurantii, Semen phaseoli radiati, Herba Patriniae, Radix Solani Torvi are taken by crude drug proportioning, mixing, micronizing is to 80 microns, with weight percent concentration 65% ethanol as solvent, 55 DEG C of warm macerating extract, and extraction time is 4 times, each extraction time is 1.5 hours, each solvent load is 16 times of medical material gross weight, filters, obtains medicinal residues A and extracting solution, extracting solution reclaims ethanol, concentration, dry, obtain extract A;
(2) step (1) obtains medicinal residues A weight percent concentration 30% ethanol is solvent, heating and refluxing extraction, extraction time is 4 times, each extraction time is 1 hour, each solvent load is 14 times of above-mentioned medical material gross weight, filter, extracting solution reclaims ethanol, it is concentrated into relative density 1.12, filter, medicinal liquid passes through LS300 macroporous adsorptive resins, first wash with water, again with the alcoholic solution eluting LS300 macroporous adsorptive resins of weight percent concentration 65%, collect weight percent concentration 65% ethanol elution, reclaim ethanol, concentrate drying, obtain extract B,
(3) taraxerol, anonaine are taken by crude drug proportioning, mixing, it is sequentially added into extract A, extract B, mixing, obtain pharmaceutical composition.
7. a kind of preparation method treating typhlitic pharmaceutical composition according to claim 5, it is characterised in that pharmaceutical composition can adopt the conventional method of galenic pharmacy to prepare into tablet or capsule or drop pill.
8. a kind of preparation method treating typhlitic pharmaceutical composition according to claim 5, it is characterised in that pharmaceutical composition and chemical drugs or Chinese medicine composition treatment appendicitis medicine.
CN201610047030.7A 2016-01-25 2016-01-25 Pharmaceutical composition for treating appendicitis and preparation method thereof Withdrawn CN105641202A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107495340A (en) * 2017-08-11 2017-12-22 安徽中森生物技术有限公司 A kind of anti-trioxypurine diuretic compositions and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107495340A (en) * 2017-08-11 2017-12-22 安徽中森生物技术有限公司 A kind of anti-trioxypurine diuretic compositions and preparation method thereof

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