CN105641126A - Traditional Chinese medicine composition for treating chest and hypochondrium fluid retaining type lung cancer hydrothorax - Google Patents

Abstract

The invention belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine composition for treating chest and hypochondrium fluid retaining type lung cancer hydrothorax. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 4 to 8 parts of impatiens leptocaulon, 4 to 8 parts of ardisia affinis hemsl, 4 to 8 parts of saussurea hieracioides, 4 to 8 parts of knoxia valerianoides, 4 to 8 parts of ginkgo root, 4 to 8 parts of aechmanthera tomentosa, 4 to 8 parts of rice bean flower, 4 to 8 parts of foochow perisimmon root and 4 to 8 parts of liquorice root. The various kinds of medicines are used together to achieve the effects of regulating qi, promoting blood circulation and removing retained water and morbid fluid; the lung cancer hydrothorax can be obviously reduced; the living quality of a patient can be improved.

Description

A kind of Chinese medicine composition treating fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer

Technical field

The invention belongs to pharmaceutical technology field, be specifically related to a kind of Chinese medicine composition treating fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer.

Background technology

Malignant pleural effusion in patients with lung cancer is one of modal complication of advanced lung cancer, and average survival time is 3.1 scholar 0.5 month, mortality rate 5.4% within 1 month, 6 months mortality rates 84%, because its obstinate difficulty disappears, has a strong impact on life in patients and life span. Current treatment mainly has systemic chemotherapy and local intrapleural injection treatment, and toxic and side effects is big, and a lot of patients with terminal are difficult to accept. and therefore, control hydrothorax, relief of symptoms, improve the main purpose that life quality is treatment advanced lung cancer hydrothorax. Therefore, a current important research topic is become for the research of malignant pleural effusion in patients with lung cancer.

Malignant pleural effusion in patients with lung cancer many genus cancer of late stage, lose operative treatment chance, mainly adopt internal medicine palliative treatment with relief of symptoms clinically, palliate the agonizing sufferings and for primary tumo(u)r implement systemic chemotherapy and local intrapleural injection be difficult to control breast water, and the simple greatly thoracentesis of side reaction can temporary relief of symptoms, but liquid can be met again rapidly, and drawing liquid makes protein and immunocyte consume therewith repeatedly, make patient's body constitution more and more weaker, and hypoproteinemia can increase the weight of the reunion of hydrothorax, can also result in hydrops parcel simultaneously, half patient's accompanying infection is even had to make disease progression, therefore simple by taking out breast water, whole body and local chemotherapy can't resolve the reunion of hydrothorax, curative effect is very undesirable, affect the emotion of patient, diet, muscle power had expendable simultaneously, cancer patient's body constitution is made to decline significantly, affect life cycle and the quality of life of patient.

Fluid-retention in the chest and hypochondrium type is the type that malignant pleural effusion in patients with lung cancer is common, has not yet to see the medicine being exclusively used in such malignant pleural effusion in patients with lung cancer.

Summary of the invention

The technical problem to be solved is to avoid the weak point existing for above-mentioned prior art, it is provided that a kind of Chinese medicine composition treating fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer.

The present invention is achieved through the following technical solutions:

A kind of Chinese medicine composition treating fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer, is made up of the Chinese medicine of following weight portion:

Impatiens leptocaulon Hook.f. 4-8 part, Ardisia affinis Hemsl. 4-8 part, Radix Saussureae hieracioidis 4-8 part, Radix Knoxiae 4-8 part, Radix Ginkgo 4-8 part, point medicine flower 4-8 part, Flos Phaseoli 4-8 part, Radix Diospyroris foochowensis 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine composition of above-mentioned treatment fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer, it is made up of the Chinese medicine of following weight portion:

Impatiens leptocaulon Hook.f. 5-7 part, Ardisia affinis Hemsl. 5-7 part, Radix Saussureae hieracioidis 5-7 part, Radix Knoxiae 5-7 part, Radix Ginkgo 5-7 part, point medicine flower 5-7 part, Flos Phaseoli 5-7 part, Radix Diospyroris foochowensis 5-7 part, Radix Glycyrrhizae 5-7 part.

It is furthermore preferred that the Chinese medicine composition of above-mentioned treatment fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer, it is made up of the Chinese medicine of following weight portion:

Impatiens leptocaulon Hook.f. 6 parts, Ardisia affinis Hemsl. 6 parts, Radix Saussureae hieracioidis 6 parts, Radix Knoxiae 6 parts, Radix Ginkgo 6 parts, point medicine spend 6 parts, Flos Phaseoli 6 parts, Radix Diospyroris foochowensis 6 parts, 6 parts of Radix Glycyrrhizae.

The ratio of above weight proportion obtains through science screening, for especial patient, such as serious symptom or mild, fat or modest patient, it is possible to the proportioning of the corresponding amount adjusting composition, increases or reduces less than 100%, and drug effect is basically unchanged.

The weight portion of said medicine, if in units of g, it is common that the consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for treating fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer.

The taboo item of Chinese medicine of the present invention: treatment is taken medicine, and fasting was greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food period.

In the Chinese medicine composition of the present invention,

Impatiens leptocaulon Hook.f. another name consumptive disease vulnerary, cool water harm, Radix Sarumatis henryi, red cold grass. , for the root and rhizome of Balsaminaceae plant Herba Impatientis leptocauli flower ImpatiensleptocaulonHook.f.. Acrid in the mouth; Bitter; Slightly warm in nature. Function vital energy regualting and blood circulation-promoting pain relieving. Main air wet arthritis; Treating swelling and pain by traumatic injury.

Ardisia affinis Hemsl. call little sunshade, within thousand, do not come out of retirement and take up an official post, short-foot sunshade, little portion umbrella, Ardisia japonica, little Herba Ardisiae Japonicae, Ardisia chinensis Benth. head, ferrum Brassaiopsis glomerulata (Bl.) Regel, for the Herb of Myrsinacea plant Ardisia affinis Hemsl. ArdisiaaffinisHemsl.. Bitter in the mouth; Pungent; Property is put down. Function smooth throat to stop cough; Vital energy regualting and blood circulation-promoting. Main laryngopharynx swelling and pain; Cough; Gastric abscess; Traumatic injury stasis of blood pain.

Radix Saussureae hieracioidis is the herb of feverfew Radix Saussureae hieracioidis SaussureahieracioidesHook.F. [S.uillosaFranch.]. Bitter in the mouth; Puckery; Cold in nature. Function removing fluid-retention by purgation. Main edema; Ascites; Cell hydrops.

The Radix Knoxiae another name erythrodontia Radix Euphorbiae Pekinensis, erythrodontia halberd, the purple Radix Euphorbiae Pekinensis, vast halberd, the Radix Euphorbiae Pekinensis, south, Jiang Juncao, wild yellow Radix Raphani, for the dry tuber of Maguireothamnus speciosus Radix Knoxiae KnoxiavalerianoidesThoreletPitard. Bitter in the mouth, cold in nature. Return lung, spleen, kidney channel. Function removing fluid-retention by purgation, merit poison dispersing swelling and dissipating binds. For chest and abdomen hydrops, difficulty in urination and defecation, carbuncle sore tumefacting virus, scrofula sucutaneous nodule.

Radix Ginkgo another name Radix Ginkgo, for root or the root bark of Ginkgoaceae plant Ginkgo biloba GinkgobilobaL.. Sweet in the mouth; Warm in nature. Function QI invigorating qi-restoratives. Main seminal emission; The enuresis; Night, frequency was many, leucorrhea, stranguria caused by urinary stone.

Point medicine flower another name Pericarpium Arecae leaf, bluet, for acanthaceous plant point medicine flower Aechmantheratomentosa(Wall.) herb of Nees [RuelliatomentosaWall.]. Sweet in the mouth; Property is put down. Function QI invigorating qi-restoratives; Promoting blood circulation and detumescence; Removing toxic substances. Main body deadhead is swooned; Traumatic injury; Fracture; Aphtha of the mouth and tongue; Venom.

Flos Phaseoli another name Caulis seu folium premnae microphyllae (Herba Premnae Microphyllae). For leguminous plant Semen Phaseoli Vignaumbellata(Thunb.) OhwietOhashi or Semen Phaseoli Vignaangularis(Willd.) flower of OwhwietOhashi. Acrid in the mouth; Slightly cool in nature. GUIXIN; Spleen; Stomach; Large intestine channel. Function removing toxic substances and promoting subsidence of swelling; Promoting the circulation of QI to induce diuresis; Improving eyesight. Main furuncle erysipelas; Insobriety; Abdominal distention and little diet; Edema; Liver-heat conjunctival congestion is dim-sighted.

Radix Diospyroris foochowensis another name wild kaki persimmon root, for the root of Ebenaceae plant crow Fructus Kaki DiospyroscathayensisSteward. Bitter in the mouth; Puckery; Cold nature. Function clearing away lung-heat; Cooling blood for hemostasis; Promoting the circulation of QI to induce diuresis. Main cough due to lung-heat; Spit blood; Hemorrhoidal hamorrhage; Hemorrhoidal bleeding; The swollen abdominal distention of water; Furuncle; Burn.

Radix Glycyrrhizae is sweet, flat. GUIXIN, lung, spleen, stomach warp. Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription. For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.

The traditional Chinese medical science is thought, cancer is owing to healthy energy is deficient, imbalance of YIN and YANG, disorder of QI movement, blood is obstructed, and raw in blood stasis, body fluid loses in defeated cloth, Tianjin is gathered for expectorant, phlegm and qi stasis, stasis blocking venation, phlegm and blood stasis forms swollen thing, and heresy stays breast to coerce, and retardance three is burnt, the long-pending knot of diseases caused by retention of fluid, sending out is hydrothorax, and its location, disease all meet hydrothorax, but invade with common exopathogen and hinder in three burnt caused hydrothoraxs different, this cause of disease carcinoma forms hydrothorax, therefore can be referred to as pernicious hydrothorax. The present inventor sums up working experience, it is believed that malignant pleural effusion in patients with lung cancer is relevant with fluid-retention in the chest and hypochondrium, and because of functional activity of QI being not smooth, channels is unfavorable, and the defeated cloth of body fluid is not smooth, builds up into drink, and therefore with vital energy regualting and blood circulation-promoting, fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer is treated in removing fluid-retention by purgation ruling by law.

The Chinese medicine composition of the present invention, its prescription mechanism is as follows:

Monarch drug: Impatiens leptocaulon Hook.f., Ardisia affinis Hemsl. merit are with vital energy regualting and blood circulation-promoting.

Ministerial drug: Radix Saussureae hieracioidis, Radix Knoxiae merit are with removing fluid-retention by purgation, merit poison dispersing swelling and dissipating binds.

Adjuvant drug: Radix Ginkgo, point medicine flower merit are with QI invigorating qi-restoratives. Flos Phaseoli, Radix Diospyroris foochowensis merit are with promoting the circulation of QI to induce diuresis.

Make medicine: Radix Glycyrrhizae merit is with coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share plays vital energy regualting and blood circulation-promoting altogether, and the effect of removing fluid-retention by purgation can obviously reduce malignant pleural effusion in patients with lung cancer, improves life in patients.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about the present invention, but and is not so limited the present invention.

Embodiment 1

A kind of Chinese medicine composition treating fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer, each crude drug weight proportion is as follows:

Impatiens leptocaulon Hook.f. 6g, Ardisia affinis Hemsl. 6g, Radix Saussureae hieracioidis 6g, Radix Knoxiae 6g, Radix Ginkgo 6g, point medicine flower 6g, Flos Phaseoli 6g, Radix Diospyroris foochowensis 6g, Radix Glycyrrhizae 6g.

Embodiment 2

A kind of Chinese medicine composition treating fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer, each crude drug weight proportion is as follows:

Impatiens leptocaulon Hook.f. 5g, Ardisia affinis Hemsl. 7g, Radix Saussureae hieracioidis 5g, Radix Knoxiae 7g, Radix Ginkgo 5g, point medicine flower 7g, Flos Phaseoli 5g, Radix Diospyroris foochowensis 7g, Radix Glycyrrhizae 5g.

Embodiment 3

A kind of Chinese medicine composition treating fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer, each crude drug weight proportion is as follows:

Impatiens leptocaulon Hook.f. 7g, Ardisia affinis Hemsl. 5g, Radix Saussureae hieracioidis 5g, Radix Knoxiae 7g, Radix Ginkgo 5g, point medicine flower 7g, Flos Phaseoli 5g, Radix Diospyroris foochowensis 7g, Radix Glycyrrhizae 5g.

Embodiment 4

A kind of Chinese medicine composition treating fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer, each crude drug weight proportion is as follows:

Impatiens leptocaulon Hook.f. 8g, Ardisia affinis Hemsl. 4g, Radix Saussureae hieracioidis 8g, Radix Knoxiae 4g, Radix Ginkgo 8g, point medicine flower 4g, Flos Phaseoli 8g, Radix Diospyroris foochowensis 4g, Radix Glycyrrhizae 8g.

Embodiment 5

A kind of Chinese medicine composition treating fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer, each crude drug weight proportion is as follows:

Impatiens leptocaulon Hook.f. 4g, Ardisia affinis Hemsl. 8g, Radix Saussureae hieracioidis 4g, red big 8g, Radix Ginkgo 4g, point medicine flower 8g, Flos Phaseoli 4g, Radix Diospyroris foochowensis 8g, Radix Glycyrrhizae 4g.

The Chinese medicine composition of the present invention has been carried out clinical pharrnacokinetics test, and Details as Follows:

1. data and method

1.1 object of study

Choose fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer patient 130 example, wherein male 81 examples, female 49 example, year mean age (58.27 �� 14.21).

1.2 diagnostic criterias

(1) all cases all has chest films showed: middle amount is to a large amount of hydrothorax, and is all diagnosed as pulmonary carcinoma through histocytology or pathology.

(2) hydrothorax measures and determines:

A small amount of hydrops: chest films showed hydrops is limited to aft rib every Jiao Chu (being difficult to find during hydrothorax minute quantity, when amount of liquid reaches more than 300ml, on posterior-anterior film of standing, visible rib is every angle rust);

Moderate hydrops: chest films showed hydrops upper limb more than the 4th rib front end level, the second rib front end below horizontal, more than rib inner edge level be a large amount of before more than the 2nd, fall between as moderate;

A large amount of hydrops: chest films showed hydrops upper limb reaches more than the 2nd rib front end.

(3) malignant pleural effusion in patients with lung cancer clinical manifestation is met, such as symptoms such as dyspnea, chest pain, coughs;

(4) health condition (Ka Shi scoring) >=50 points, it is contemplated that life cycle > 3.5 months;

(5) infection conditions person is got rid of through laboratory or imaging examination.

TCM Syndrome Type diagnostic criteria: " clinical TCM Oncology " with reference to Zhou Daihan chief editor is formulated, and belongs to malignant pleural effusion in patients with lung cancer fluid-retention in the chest and hypochondrium type person: primary symptom: decrescence, asthma breath is short to be increased the weight of dragging pain due to cough and spitting, fullness and distention in the chest and hypochondrium, very then visible side protuberance partially. Secondary disease: can not put down sleeping, or be only capable of partially crouching in Ipsilateral; Tongue arteries and veins: thin white fur of tongue, deep and stringy pulse or stringy and rolling pulse. Primary symptom two+secondary disease two is diagnosable in conjunction with tongue vein.

1.3 inclusive criterias

(1) patient of the malignant pleural effusion with lung cancer that histopathology or cytology make a definite diagnosis; And check that hydrothorax is more than moderate through x-ray;

(2) pattern of syndrome belongs to fluid-retention in the chest and hypochondrium type person;

(3) age 40-80 year;

(4) adopting Chinese medicine as primary treatments: doctor trained in Western medicine radiotherapy, chemotherapy exceed February after stopping, not row operation, radiotherapy gets involved, the patient of the methods such as Biotherapeutics;

(5) life span is be more than or equal to March;

(6) Ka Shi mark 50 points or more than;

(7) informed consent person.

1.4 Excluded cases standards

(1) patient of above-mentioned Disease Diagnosis Standard is not met;

(2) other malignant tumor person that need to simultaneously treat it is associated with;

(3) observation process failed the patient of this research process;

(4) researcher is thought and should not be carried out this clinical trial person;

(5) the serious heart, brain, kidney or disease of hematopoietic system and psychotic it are associated with;

(6) compliance is bad, refuses partner;

(7) the hydrothorax person that other internal diseases such as pulmonary tuberculosis, heart failure, liver cirrhosis, nephrotic syndrome etc. are caused is got rid of

(8) age is less than 40 years old or more than 80 years old, pregnant or women breast-feeding their children.

The rejecting of 1.5 cases and coming off

(1) therapist can not be adhered to;

(2) therapeutic scheme executor is not pressed;

(3) experimenter of serious adverse events/untoward reaction occurs;

(4) therapeutic process occurs other serious complication or sb.'s illness took a turn for the worse person;

(5) researcher thinks that proceeding test may cause damage to experimenter.

1.6 Therapeutic Method

Give the traditional Chinese medicine composition for treating of the embodiment of the present invention 1, prescription is as follows: Impatiens leptocaulon Hook.f. 6g, Ardisia affinis Hemsl. 6g, Radix Saussureae hieracioidis 6g, Radix Knoxiae 6g, Radix Ginkgo 6g, point medicine flower 6g, Flos Phaseoli 6g, Radix Diospyroris foochowensis 6g, Radix Glycyrrhizae 6g, it is decocted in water for oral dose, day potion, sooner or later sub-service, with 7d for a course for the treatment of.

1.7 observation index

(1) hydrothorax treatment situation: check rabat before and after treatment, records hydrothorax amount.

(2) life quality: mark by the life quality standard of tumour patient and Ka Shi and score, observe cough, cough up phlegm, uncomfortable in chest, tachypnea, the situation such as edema is with or without improvement.

(3) safety detection: include routine blood test, liver function, renal function and electrocardiogram.

1.8 criterions of therapeutical effect

(1) complete incidence graph (CR): hydrothorax fully absorbs, transference cure, has no hydrothorax through clinical, x-ray inspection, and maintains more than 4 weeks;

(2) through clinical, x-ray, partial rcsponse (PR): hydrothorax substantially reduces, and symptom alleviates, checks that hydrothorax reduces by more than 1/2, and maintains week more than;

(3) invalid (NC): hydrothorax still continued propagation after treatment, or hydrothorax minimizing is inconspicuous, and symptom is without improvement, or continues to increase the weight of;

(4) worsening (PD): hydrothorax increases, symptom is without improving or increasing the weight of.

(CR+PR) %=effective percentage

1.9 statistical method

SPSS14.0 version statistical software is adopted to be analyzed. Measurement data is added and subtracted standard deviation with mean and is represented, compares employing t inspection before and after treatment, and enumeration data represents with percentage rate, compares employing X 2 test, represent that difference has statistical significance with P < 0.05 before and after treatment.

2. result

Before and after 2.1 treatments, hydrothorax amount compares

Average hydrothorax amount is reduced to (30.34 �� 9.87) ml after treatment by (342.41 �� 49.34) ml before treating, and difference has statistical significance (t=6.183, P < 0.05).

2.2 treatment Life For The Residents of Three Gorges Reservoir Befores

Ping Junkashi scoring is risen to (89.32 �� 7.12) ml after treatment by (57.34 �� 8.27) ml before treating, and difference has statistical significance (t=5.723, P < 0.05).

2.3 clinical efficacies

130 example patient clinical curative effects: complete incidence graph 116 example, partial rcsponse 10 example, invalid 4 examples, worsen 0 example. Curative effect: complete remission rate 89.2%, total effective rate is 96.9%.

2.4 safety analysiss

Treatment Patients Before And After routine blood test, Liver and kidney merit and electrocardiogram are without significant change, and drug safety is better.

Claims (3)

1. treat a Chinese medicine composition for fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer, be made up of the Chinese medicine of following weight portion:

Impatiens leptocaulon Hook.f. 4-8 part, Ardisia affinis Hemsl. 4-8 part, Radix Saussureae hieracioidis 4-8 part, Radix Knoxiae 4-8 part, Radix Ginkgo 4-8 part, point medicine flower 4-8 part, Flos Phaseoli 4-8 part, Radix Diospyroris foochowensis 4-8 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine composition for the treatment of fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer according to claim 1, it is characterised in that be made up of the Chinese medicine of following weight portion:

Impatiens leptocaulon Hook.f. 5-7 part, Ardisia affinis Hemsl. 5-7 part, Radix Saussureae hieracioidis 5-7 part, Radix Knoxiae 5-7 part, Radix Ginkgo 5-7 part, point medicine flower 5-7 part, Flos Phaseoli 5-7 part, Radix Diospyroris foochowensis 5-7 part, Radix Glycyrrhizae 5-7 part.

3. the Chinese medicine composition for the treatment of fluid-retention in the chest and hypochondrium type malignant pleural effusion in patients with lung cancer according to claim 3, it is characterised in that be made up of the Chinese medicine of following weight portion:

Impatiens leptocaulon Hook.f. 6 parts, Ardisia affinis Hemsl. 6 parts, Radix Saussureae hieracioidis 6 parts, Radix Knoxiae 6 parts, Radix Ginkgo 6 parts, point medicine spend 6 parts, Flos Phaseoli 6 parts, Radix Diospyroris foochowensis 6 parts, 6 parts of Radix Glycyrrhizae.