Summary of the invention
Embodiment of the present invention technical problem to be solved is in that; there is provided one will be wrapped in microsphere to the effective active skull cap components of skin; avoid active ingredient contacts to aoxidize to illumination and air effect, give the exfoliation microsphere with soft skin whitening that functional component obtains better protection in microsphere.
The described exfoliation microsphere with soft skin whitening, wraps up component and structure is: ground floor: papain; The second layer: particulate active charcoal (INCI: powdered carbon); Third layer: tea stamen extract (INCI: tea (CAMELLIASINENSIS) extract).
The preparation method of a kind of exfoliation microsphere as having soft skin whitening, comprises the steps:
(1) sucrose, starch, microcrystalline Cellulose being pressed 7:2:1 mixing, be added to the water, heating, to boiling, is brewed into syrup, tea blend stamen extract;
(2) by fluid unit spray drying, small sugar pill granule is made;
(3) by coating binding agent hydroxypropyl cellulose, being dissolved in the ethanol of 95% in the ratio of 5%, stirring to hydroxypropyl cellulose is completely dissolved;
(4) Coating Solution adds activated carbon, blend compounds body grinds uniformly;
(5) by fluid unit side spray technique, the sugar pill extra-granular in step 2 is wrapped up the activated carbon slurry mixed, makes parcel bead;
(6) by coating binding agent hydroxypropyl cellulose, being dissolved in the ethanol of 95% in the ratio of 5%, stirring to hydroxypropyl cellulose is completely dissolved;
(7) Coating Solution adding papain, blend compounds body grinds uniformly;
(8) by the parcel bead in step 5, by fluid unit side spray technique, parcel last layer papain slurry, make multiple parcel bead, finally spray bronze outside and make finished product.
Exfoliation microsphere can expand the several functions of product, and its effect principle improves skin problem by a dissolving, two absorption, three nourishing whitenings, plays triple functions:
First weight: dissolve, uses Papain enzyme viability to dissolve aging cutin layer;
Second weight: absorption, adsorbs the dirt in skin pore by particulate active carbon dust;
The triple: whitening is nourished, and tea stamen extract brings whitening, moisturizing, moistens triple nutrition reparations to the skin dispelling cutin containing abundant tea polyphenols, catechin. Dead bark, cleaning skin can be removed, can also make that skin is soft simultaneously, water profit, whitening.
The embodiment of the present invention additionally provides the quality of chamfering of a kind of exfoliation microsphere including and having soft skin whitening, include following composition by weight percentage: PEG-4000 1-5%, glycerol 1-15%, lauroyl PG-trimethyl ammonium chloride 5-15%, carbomer 0.2-2.5%, papain 0.1-10%, tea extract 0.1-10%, powdered carbon 0.1-1%, wing seed moringa seeds extract 0.1-10%, Herba Saussureae Involueratae extract 1-5%, edelweiss extract 1-5%, corn starch 0.1-2.5%, microcrystalline Cellulose 0.1-2.5%, sucrose 0.1-2.5, lactose 0.1-2.5%, hydroxypropyl methyl cellulose 0.1-2.5%, lecithin 1-5%, Sensiva SC50 0.1-0.5%, phenoxyethanol 0.1-0.3%, Cremophor RH40 0.1-0.5%, essence 0.05-0.5%, remaining is all water.
The present embodiment additionally provides the preparation method chamfering quality of a kind of exfoliation microsphere with soft skin whitening, comprises the steps:
1, weigh above-mentioned raw materials, deionized water is added and vacuum stirring pot heats to 90 DEG C of sterilizings half an hour, be cooled to 30 DEG C;
2, maintain mixing speed 60 revs/min, be sequentially added into glycerol, PEG-4000, corn starch, microcrystalline Cellulose, sucrose, lactose, hydroxypropyl methyl cellulose, stir 20 minutes;
3, add carbomer, open stirring 30 revs/min, homogenizing 5 minutes;
4, vacuum outgas 20 minutes;
5, mixing speed is down to 20 revs/min, adds lauroyl PG-trimethyl ammonium chloride, slow stirring 15 minutes;
6, maintain 20 revs/min, add remaining raw material: papain, tea extract, powdered carbon, edelweiss extract, wing seed moringa seeds extract, Herba Saussureae Involueratae extract, lecithin, Sensiva SC50, phenoxyethanol, Cremophor RH40, essence stir;
7, discharging, stands, after the assay was approved, and fill, packaging, coding;
8, after the assay was approved, warehouse-in.
The UES-L that the present embodiment is processed by microcapsule technique for packing3It is applied in exfoliation product in Function, possesses three categorles skin protection advantages:
1. targeting: UES-L3By with skin contact after slowly discharge active ingredient, targeting dissolve cutaneous ageing horn cell, absorption pore gap in dirt, be finally skin income nutritional labeling;
2. slow-releasing: UES-L3By slowly discharging triple active ingredients of its parcel with skin contact, solve skin problem and demand stage by stage;
3. fresh and alive property: UES-L3Effective active skull cap components is wrapped in microsphere, it is to avoid active ingredient contacts aoxidizes to illumination and air effect, keeps its activity to greatest extent.
By the microcapsule technique for packing that binding agent HPMC and lactose make; to the effective active skull cap components of skin be wrapped in microsphere; active ingredient contacts is avoided to aoxidize to illumination and air effect; give functional component better to be protected in microsphere; allow natural component keep its activity before contact skin to greatest extent, be greatly improved the various effect of product.
Papain can well dissolve aging cutin layer, additionally, there is (CAMELLIASINENSIS) extract of antioxidation, convergence pore effect), and there is the particulate active charcoal of superpower absorbability, it is thus achieved that Exfoliating Scrub, clean skin, soft, water profit, whitening etc. are multi-functional chamfers quality in soft whitening integrally. Experimental data proves definite effect of the present invention, action pathway is various, safely, have no adverse reaction, adapt to all kinds of skin quality, use rear skin to recover rapidly water profit, bright, elastic, thoroughly compensate for the open defect of commercially available prod function singleness.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly, below the present invention is described in further detail.
The embodiment of the present invention has the exfoliation microsphere of soft skin whitening, wraps up component and structure is: ground floor: papain; The second layer: particulate active charcoal (INCI: powdered carbon); Third layer: tea stamen extract (INCI: tea (CAMELLIASINENSIS) extract).
The preparation method of a kind of exfoliation microsphere with soft skin whitening, comprises the steps:
(1) sucrose, starch, microcrystalline Cellulose being pressed 7:2:1 mixing, be added to the water, heating, to boiling, is brewed into syrup, tea blend stamen extract;
(2) by fluid unit spray drying, small sugar pill granule is made;
(3) by coating binding agent hydroxypropyl cellulose, being dissolved in the ethanol of 95% in the ratio of 5%, stirring to hydroxypropyl cellulose is completely dissolved;
(4) Coating Solution adds activated carbon, blend compounds body grinds uniformly;
(5) by fluid unit side spray technique, the sugar pill extra-granular in step 2 is wrapped up the activated carbon slurry mixed, makes parcel bead;
(6) by coating binding agent hydroxypropyl cellulose, being dissolved in the ethanol of 95% in the ratio of 5%, stirring to hydroxypropyl cellulose is completely dissolved;
(7) Coating Solution adding papain, blend compounds body grinds uniformly;
(8) by the parcel bead in step 5, by fluid unit side spray technique, parcel last layer papain slurry, make multiple parcel bead, finally spray bronze outside and make finished product.
Exfoliation microsphere can expand the several functions of product, and its effect principle improves skin problem by a dissolving, two absorption, three nourishing whitenings, plays triple functions:
First weight: dissolve, uses Papain enzyme viability to dissolve aging cutin layer;
Second weight: absorption, adsorbs the dirt in skin pore by particulate active carbon dust;
The triple: whitening is nourished, and tea stamen extract brings whitening, moisturizing, moistens triple nutrition reparations to the skin dispelling cutin containing abundant tea polyphenols, catechin. Dead bark, cleaning skin can be removed, can also make that skin is soft simultaneously, water profit, whitening.
Include the quality of chamfering of the above-mentioned exfoliation microsphere with soft skin whitening, include following composition by weight percentage:
Concrete preparation technology is as follows:
1, deionized water is added in vacuum stirring pot and heat to 90 DEG C of sterilizings half an hour, be cooled to 30 DEG C;
2, maintain mixing speed 60 revs/min, be sequentially added into glycerol, PEG-4000, corn starch, microcrystalline Cellulose, sucrose, lactose, hydroxypropyl methyl cellulose, stir 20 minutes;
3, add carbomer, open stirring 30 revs/min, homogenizing 5 minutes;
4, vacuum outgas 20 minutes;
5, mixing speed is down to 20 revs/min, adds cocoyl front three ammonium chloride, slow stirring 15 minutes;
6, maintain 20 revs/min, add remaining raw material: papain, tea (CAMELLIASINENSIS) extract, powdered carbon, edelweiss (LEONTOPODIUMALPINUM) extract, wing seed Moringa (MORINGAPTERYGOSPERMA) seed extract, Herba Saussureae Involueratae (SAUSSUREAINVOLUCRATA) extract, lecithin, Sensiva SC50, phenoxyethanol, Cremophor RH40, essence stir;
7, discharging, stands, after the assay was approved, and fill, packaging, coding;
8, after the assay was approved, warehouse-in.
Contrast of testing is divided to the above-mentioned tender effect chamfering quality and certain brand commercially available in vain of the tea stamen made:
1, skin smoothness rate of change test
Look for 10 ages female volunteers between 18��50 years old, more than face uses, quality and commercially available common quality of chamfering are chamfered in soft whitening respectively, adopting the test of VISIA face-image analyser, comprehensive acquirement smoothness data, data value more high expression skin smoothness is more poor. Test result is following table such as:
Sample |
Before using |
Use latter 1 hour |
Use latter 2 hours |
Embodiment 1 |
2.8561 |
-0.2386 |
-0.2215 |
Embodiment 2 |
2.7413 |
-0.2246 |
-0.2159 |
Embodiment 3 |
2.9456 |
-0.2145 |
-0.2018 |
Reference examples |
2.8627 |
0.8752 |
0.9951 |
Commercially available common quality of chamfering |
2.7561 |
0.6512 |
0.7514 |
From test data, after the present invention relatively commercially available prod uses, skin has better smooth.
2, replenishing water and preserving moisture performance test
Look for 10 ages female volunteers between 18��50, at 20 DEG C, in the indoor environment of relative humidity 50%, the fixed area of one 2 square centimeters is drawn respectively at forehead, more than fixed area uses, quality and commercially available common chamfer after quality is chamfered in soft whitening, testing with CorneometerCM285 skin moisture detector, comprehensive acquirement humidity of skin delta data, test result is following table such as:
From test data, the present invention relatively commercially available prod has better moisturizing and moisture retention.
3, whitening performance test
Look for 10 ages 18-50 year between female volunteers, use that above tea stamen is tender chamfers quality and commercially available common quality of chamfering in vain respectively in face, study subject uses once every day, uses 30 days continuously, does not use other any product during test. Ambient temperature 25 �� 1 DEG C, under humidity 50 �� 5% condition, adopt MEXAMETERMX16 skin pigment analyser, after using first 1 day of exfoliation and using 30 days continuously, measure the melanin content (averaging) of its facial skin, the white-skinned face function of the said goods is evaluated. The melanin suppression ratio result such as following table that test obtains:
Can be seen that from above experimental result, the present invention is high to melanin suppression ratio, and the whitening effect being relatively not added with " super exfoliation microsphere " triple microcapsules parcel papain, particulate active charcoal (INCI: powdered carbon), the reference examples of tea stamen extract (INCI: tea (CAMELLIASINENSIS) extract) and commercially available common exfoliation is notable.
The UES-L that the present embodiment is processed by microcapsule technique for packing3It is applied in exfoliation product in Function, possesses three categorles skin protection advantages:
1, targeting: UES-L3By with skin contact after slowly discharge active ingredient, targeting dissolve cutaneous ageing horn cell, absorption pore gap in dirt, be finally skin income nutritional labeling;
2, slow-releasing: UES-L3By slowly discharging triple active ingredients of its parcel with skin contact, solve skin problem and demand stage by stage;
3, fresh and alive property: UES-L3Effective active skull cap components is wrapped in microsphere, it is to avoid active ingredient contacts aoxidizes to illumination and air effect, keeps its activity to greatest extent.
By the microcapsule technique for packing that binding agent HPMC and lactose make; to the effective active skull cap components of skin be wrapped in microsphere; active ingredient contacts is avoided to aoxidize to illumination and air effect; give functional component better to be protected in microsphere; allow natural component keep its activity before contact skin to greatest extent, be greatly improved the various effect of product.
Papain can well dissolve aging cutin layer, additionally, there is (CAMELLIASINENSIS) extract of antioxidation, convergence pore effect), and there is the particulate active charcoal of superpower absorbability, it is thus achieved that Exfoliating Scrub, clean skin, soft, water profit, whitening etc. are multi-functional chamfers quality in soft whitening integrally. Experimental data proves definite effect of the present invention, action pathway is various, safely, have no adverse reaction, adapt to all kinds of skin quality, use rear skin to recover rapidly water profit, bright, elastic, thoroughly compensate for the open defect of commercially available prod function singleness.