CN105638999A - Preparation method of flos lonicerae and strigose hydrangea juvenile leaf composite tea - Google Patents
Preparation method of flos lonicerae and strigose hydrangea juvenile leaf composite tea Download PDFInfo
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- CN105638999A CN105638999A CN201511024533.4A CN201511024533A CN105638999A CN 105638999 A CN105638999 A CN 105638999A CN 201511024533 A CN201511024533 A CN 201511024533A CN 105638999 A CN105638999 A CN 105638999A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
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Abstract
The invention relates to the technical field of preparation of composite tea and in particular relates to a preparation method of flos lonicerae and strigose hydrangea juvenile leaf composite tea. The preparation method comprises the following preparation steps: (1) weighing flos lonicerae and strigose hydrangea juvenile leaf according to a weight ratio and crushing; (2) treating the flos lonicerae and the strigose hydrangea juvenile leaf under high pressure; (3) extracting the flos lonicerae and the strigose hydrangea juvenile leaf by ultrasonic waves; (4) stirring extracting liquid obtained by the step (3), concentrating, spraying and drying to obtain the composite tea. The flos lonicerae and strigose hydrangea juvenile leaf composite tea prepared by the method provided by the invention has a relatively strong anti-tumor effect.
Description
Technical field
The present invention relates to compound tea preparing technical field, in particular to the preparation method of a kind of honeysuckle sweet tea compound tea.
Background technology
Japanese Honeysuckle, has another name called honeysuckle (formal name used at school: Lonicerajaponica). " Japanese Honeysuckle " one comes from Compendium of Material Medica, owing to opening as white at the beginning of Flos Lonicerae, after transfer yellow to, hence obtain one's name Japanese Honeysuckle. Medicinal material Japanese Honeysuckle is Caprifoliaceae woodbine honeysuckle and congener dry flower or is with the flower just opened. Japanese Honeysuckle is just extensive and famous with its pharmaceutical use since ancient times. Its property sweet cold air fragrance, clearing away heat with drugs sweet in flavor and cold in nature and do not hinder stomach, fragrance thoroughly reaches and can be eliminating evil. Its effect is mainly clearing heat and detoxicating, cures mainly warm disease heating, toxic-heat and blood stasis, ulcer serious case of furuncle etc. Modern study proves, Japanese Honeysuckle contains the pharmacological component such as chlorogenic acid, luteolin glycosides, the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc. there is stronger suppression power, in addition also can strengthening immunity, antiearly pregnancy, protect liver, antitumor, anti-inflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, can be used for the treatment of respiratory tract infection, bacillary dysentery, acute urinary system infection, hypertension etc. more than 40 with other compatibility of drugs and plant illness.
Sweet tea is containing abundant nutritive substance and the necessary trace element of human body. Confirm according to unit test results such as Guangxi Bureau of Technical Supervision analysis testing research centers: Wild sweet tea is rich in 18 seed amino acids, every 100 grams of dry products are containing total amino acid content 331.54 milligrams, particularly sweet tea is rich in human body necessary, human body can not generate, 8 seed amino acids that can only absorb from food. Mainly contain calcium 0.84%, zinc 105.5mg/kg, germanium 5.5 �� g/kg, selenium 17.94 �� g/kg, and the multiple element such as potassium, magnesium, phosphorus, iron, sodium, copper, chromium, strontium, lithium, containing the toxic substance such as arsenic aluminium, not containing dizziness can be produced, heartbeat acceleration, palpitaition, anxiety irritability, Psychological inadaptability, interference are slept, etc. the caffeine of side effect; Wherein contained germanium, selenium etc., be all better than general green tea and Leaf of Chinese Holly. Guangxi Folium hydrangeae strigosae has the special effect fruit naturally sweet without sugar, owing to effect is numerous, is described as god's tea. Normal drink has effect of nourishing liver and kidney, pharynx clearing heat and detoxicating, promoting production of body fluid and nourishing the lung, relieving cough and reducing sputum, sharp, can prevent and treat the diseases such as heat is coughed, pharyngolaryngitis, hoarseness; To hyperchlorhydria person, strong spleen is had to dispel stagnant, stomach digestion-aid effect;After drink spills excessive drinking, can refresh oneself wakes up spills; Also have simultaneously carry body immunity, cancer-resisting antianaphylaxis, anti-fat lipid-lowering and blood-pressure-lowing, reduction blood courage solid liquor-saturated, suppress and delay arteriosclerosis, and prevent and treat coronary heart disease, diabetes and sacroiliitis, numerous nourishing functions such as anti-ageing, beauty treatment, all-ages, it is the functional health tea of low heat value, sweet taste, the drug effect trinity.
The present invention studies discovery, and taking Japanese Honeysuckle and sweet tea as raw material, the compound tea adopting preparation method of the present invention to prepare has stronger antitumor action.
Summary of the invention
Technical problem to be solved by this invention is to provide the preparation method of a kind of honeysuckle sweet tea compound tea, and the compound tea that the method prepares has stronger antitumor action.
For achieving the above object, the present invention adopts following technical scheme:
The present invention provides the preparation method of a kind of honeysuckle sweet tea compound tea, comprises following preparation process:
1) it is that 4��8:5��13 take Japanese Honeysuckle and sweet tea by weight, pulverizes;
2) Japanese Honeysuckle and sweet tea are mixed, add their gross weights 3��6 times of ethanolic solns, put into pressure pan, be forced into 0.6��1.8MPa so that it is pressure uniform, and keep 3��8min, recover normal pressure, obtain slurries;
3) to step 2) slurries that obtain add Japanese Honeysuckle and sweet tea gross weight 2��5 times of ethanolic solns again, at 35��45 DEG C, carry out supersound extraction, obtain extracting solution;
4) by step 3) extracting solution that obtains stirs at 30��40 DEG C, and concentrated, spraying dry, obtains compound tea.
Preferably, step 1 of the present invention) in, Japanese Honeysuckle and sweet tea are crushed to 50��100 orders respectively.
Preferably, the volume fraction of ethanolic soln of the present invention is 80��95%.
Preferably, step 3 of the present invention) in, ultrasonic extraction conditions is: power is 500��700W, and the time is 20��30min.
Preferably, step 4 of the present invention) in, stir 5��10min.
The honeysuckle sweet tea compound tea that the method that the present invention also provides described prepares, the compound tea that the method prepares has stronger antitumor action.
Japanese Honeysuckle of the present invention and sweet tea are dry product.
Compared with prior art, the present invention is before supersound extraction, with autoclaving Japanese Honeysuckle and sweet tea, utilize effective constituent from non-active ingredients to the different holding capacity of high pressure, and effective constituent is separated with non-active ingredients, improve extraction yield, improve effect, use supersound extraction raw material again, mild condition, can ensure that effective constituent wherein is not destroyed to large extent, there is higher extraction yield, and relatively save time, shorten the production cycle, Flos Lonicerae extractive solution is mixed with sweet tea extract, stir at a certain temperature, Japanese Honeysuckle and sweet tea effective constituent are better neutralized, the honeysuckle sweet tea compound tea prepared has stronger antitumor action.
Embodiment
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited to these embodiments.
Embodiment 1
1) by weight taking Japanese Honeysuckle and sweet tea for 4:5, it is crushed to 50 orders;
2) Japanese Honeysuckle and sweet tea being mixed, adding their gross weights 6 times of volume fractions is the ethanolic soln of 80%, puts into pressure pan, is forced into 1.8MPa so that it is pressure uniform, and keeps 3min, recovers normal pressure, obtains slurries;
3) to step 2) slurries that obtain add Japanese Honeysuckle again and sweet tea gross weight 3 times of volume fractions are the ethanolic soln of 80%, at 45 DEG C, carry out supersound extraction, ultrasonic extraction conditions is: power is 500W, and the time is 28min, obtains extracting solution;
4) by step 3) extracting solution that obtains stirs 10min at 30 DEG C, and concentrated, spraying dry, obtains compound tea.
Embodiment 2
1) by weight taking Japanese Honeysuckle and sweet tea for 5:7, it is crushed to 60 orders;
2) Japanese Honeysuckle and sweet tea being mixed, adding their gross weights 5 times of volume fractions is the ethanolic soln of 85%, puts into pressure pan, is forced into 1.5MPa so that it is pressure uniform, and keeps 4min, recovers normal pressure, obtains slurries;
3) to step 2) slurries that obtain add Japanese Honeysuckle again and sweet tea gross weight 5 times of volume fractions are the ethanolic soln of 90%, at 42 DEG C, carry out supersound extraction, ultrasonic extraction conditions is: power is 550W, and the time is 25min, obtains extracting solution;
4) by step 3) extracting solution that obtains stirs 9min at 33 DEG C, and concentrated, spraying dry, obtains compound tea.
Embodiment 3
1) by weight taking Japanese Honeysuckle and sweet tea for 6:9, it is crushed to 70 orders;
2) Japanese Honeysuckle and sweet tea being mixed, adding their gross weights 5 times of volume fractions is the ethanolic soln of 90%, puts into pressure pan, is forced into 1.2MPa so that it is pressure uniform, and keeps 5min, recovers normal pressure, obtains slurries;
3) to step 2) slurries that obtain add Japanese Honeysuckle again and sweet tea gross weight 4 times of volume fractions are the ethanolic soln of 85%, at 40 DEG C, carry out supersound extraction, ultrasonic extraction conditions is: power is 600W, and the time is 23min, obtains extracting solution;
4) by step 3) extracting solution that obtains stirs 8min at 35 DEG C, and concentrated, spraying dry, obtains compound tea.
Embodiment 4
1) by weight taking Japanese Honeysuckle and sweet tea for 7:11, it is crushed to 80 orders;
2) Japanese Honeysuckle and sweet tea being mixed, adding their gross weights 4 times of volume fractions is the ethanolic soln of 95%, puts into pressure pan, is forced into 0.9MPa so that it is pressure uniform, and keeps 7min, recovers normal pressure, obtains slurries;
3) to step 2) slurries that obtain add Japanese Honeysuckle again and sweet tea gross weight 3 times of volume fractions are the ethanolic soln of 95%, at 38 DEG C, carry out supersound extraction, ultrasonic extraction conditions is: power is 650W, and the time is 30min, obtains extracting solution;
4) by step 3) extracting solution that obtains stirs 7min at 37 DEG C, and concentrated, spraying dry, obtains compound tea.
Embodiment 5
1) by weight taking Japanese Honeysuckle and sweet tea for 8:13, it is crushed to 100 orders;
2) Japanese Honeysuckle and sweet tea being mixed, adding their gross weights 3 times of volume fractions is the ethanolic soln of 85%, puts into pressure pan, is forced into 0.6MPa so that it is pressure uniform, and keeps 8min, recovers normal pressure, obtains slurries;
3) to step 2) slurries that obtain add Japanese Honeysuckle again and sweet tea gross weight 2 times of volume fractions are the ethanolic soln of 80%, at 35 DEG C, carry out supersound extraction, ultrasonic extraction conditions is: power is 700W, and the time is 20min, obtains extracting solution;
4) by step 3) extracting solution that obtains stirs 5min at 40 DEG C, and concentrated, spraying dry, obtains compound tea.
Test example: the honeysuckle sweet tea compound tea antineoplastic action effect that the method for the invention prepares
1, laboratory animal: healthy Kunming mouse, body weight (20 �� 2) g, male and female half and half, are provided by Guangxi Medical University's Experimental Animal Center.
2, tumor cell line: murine sarcoma S180Ascit form, is provided by Guangxi treatment and prevention of tumour institute.
3, medicament preparation:
Get A group (general commercially available Japanese Honeysuckle) and B group (general commercially available sweet tea) 10g respectively, it is crushed to 100 orders, it is placed in the glass beaker of 1000mL, add water 500mL, after soaking 1h, is placed on fire and decocts, first intense fire changes slow fire into after boiling, stop working after decocting 60min again, by centrifugal for liquid 3500r/min 5min, clear liquid medicine in taking-up.And then add 300mL water in sediment, decoct again twice by same method. 3 upper clear liquid medicine mixing are placed on slow fire, concentrate and determine Rongcheng 200mL, make the original liquid containing crude drug 5%, this liquid is sealed, be placed in refrigerator cold-storage and save backup.
The process of C group: getting C group (the honeysuckle sweet tea compound tea that embodiment 3 prepares) 10g, be placed in the glass beaker of 1000mL, add water 500mL, by centrifugal for liquid 3500r/min 5min, clear liquid medicine in taking-up. The mixing of upper clear liquid medicine is placed on slow fire, concentrates and determine Rongcheng 200mL, make the original liquid containing crude drug 5%, this liquid is sealed, be placed in refrigerator cold-storage and save backup.
4, experimental technique:
Getting (20 �� 2) g mouse 40, forelimb is subcutaneous inoculates the murine sarcoma S gone down to posterity the 7th day through kunming mouse respectively180Through platform, abdominal cavity diluent 0.2mL that knurl strain cell (expects that blue stain living cells number is greater than 95%), its concentration 5 �� 105/ mL. Mouse after injection oncocyte being divided into 4 groups at random, often organizes 10, male and female half and half: control group, with side with position injecting normal saline 0.5mL; A group, injects A group original liquid diluent 0.25mL with side with position, and whole dosage is every injected in mice Japanese Honeysuckle composition 0.5mg; B group, injects B group original liquid diluent 0.25mL with side with position, and whole dosage is every sweet tea component 0.5mg of injected in mice. C group, injects C group original liquid diluent 0.25mL with side with position, and whole dosage is every injected in mice honeysuckle sweet tea compound tea component 0.5mg. Observe the Survival of the animation of mouse, tumor growth situation and mouse.
5, test-results:
From experiment, observe the life situation of every mouse at any time. Control group mice starts naked eyes swollen block (about 0.15cm �� 0.15cm) as seen occur for 1 week, and A group, B group and C group then have no macroscopic swollen block. A group, B group and C group mouse all survive.
Continuing to observe and within the 18th day, rise to experiment, control group mice starts dead gradually, all dead to 35 days control groups. A group, B group and C group mouse then all survive, and naked eyes swollen block as seen all do not occur.
Continuing to observe to the 44th day, there is naked eyes swollen block as seen in A group mouse, continues to observe and within the 54th day, rises to experiment, and A group mouse starts dead gradually, all dead to 67 days A group mouse.
Continuing to observe to the 46th day, there is naked eyes swollen block as seen in B group mouse, continues to observe and within the 57th day, rises to experiment, and B group mouse starts dead gradually, all dead to 68 days B group mouse
Continuing to observe to the 70th day, there is naked eyes swollen block as seen in C group mouse, continues to observe and within the 85th day, rises to experiment, and C group mouse starts dead gradually, all dead to 105 days C group mouse
This experiment repeats 4 times altogether, and result is substantially identical. The Survival of mouse is in table 1.
The different group medicament anti-mouse S of table 1180The experimental observations of ascites type sarcoma
Upper table shows, A group, B group and C group are to S180Ascites type sarcoma cell has restraining effect, but C group inhibition is comparatively remarkable, illustrates that the honeysuckle sweet tea compound tea that the method for the invention prepares has stronger antitumor action.
Claims (6)
1. the preparation method of a honeysuckle sweet tea compound tea, it is characterised in that, comprise following preparation process:
1) it is that 4��8:5��13 take Japanese Honeysuckle and sweet tea by weight, pulverizes;
2) Japanese Honeysuckle and sweet tea are mixed, add their gross weights 3��6 times of ethanolic solns, put into pressure pan, be forced into 0.6��1.8MPa so that it is pressure uniform, and keep 3��8min, recover normal pressure, obtain slurries;
3) to step 2) slurries that obtain add Japanese Honeysuckle and sweet tea gross weight 2��5 times of ethanolic solns again, at 35��45 DEG C, carry out supersound extraction, obtain extracting solution;
4) by step 3) extracting solution that obtains stirs at 30��40 DEG C, and concentrated, spraying dry, obtains compound tea.
2. the preparation method of honeysuckle sweet tea compound tea according to claim 1, it is characterised in that: described step 1) in, Japanese Honeysuckle and sweet tea are crushed to 50��100 orders respectively.
3. the preparation method of honeysuckle sweet tea compound tea according to claim 1, it is characterised in that: the volume fraction of described ethanolic soln is 80��95%.
4. the preparation method of honeysuckle sweet tea compound tea according to claim 3, it is characterised in that: described step 3) in, ultrasonic extraction conditions is: power is 500��700W, and the time is 20��30min.
5. the preparation method of honeysuckle sweet tea compound tea according to claim 1, it is characterised in that: described step 4) in, stir 5��10min.
6. the honeysuckle sweet tea compound tea that method according to Claims 1 to 5 any one prepares.
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| CN201511024533.4A CN105638999A (en) | 2015-12-31 | 2015-12-31 | Preparation method of flos lonicerae and strigose hydrangea juvenile leaf composite tea |
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| CN201511024533.4A CN105638999A (en) | 2015-12-31 | 2015-12-31 | Preparation method of flos lonicerae and strigose hydrangea juvenile leaf composite tea |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040644A (en) * | 2007-04-18 | 2007-09-26 | 广西巴马常春藤生命科技发展有限公司 | Health-care tea |
| CN102144692A (en) * | 2010-09-25 | 2011-08-10 | 重庆辰龙制药有限公司 | Sweet tea and preparation method thereof |
| CN103005091A (en) * | 2012-11-30 | 2013-04-03 | 李胜华 | Lithocarpus polysachyus rehd leaf instant tea powder and production process thereof |
| CN103120348A (en) * | 2013-03-11 | 2013-05-29 | 朱世超 | Honeysuckle flower distillate beverage and production method thereof |
-
2015
- 2015-12-31 CN CN201511024533.4A patent/CN105638999A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101040644A (en) * | 2007-04-18 | 2007-09-26 | 广西巴马常春藤生命科技发展有限公司 | Health-care tea |
| CN102144692A (en) * | 2010-09-25 | 2011-08-10 | 重庆辰龙制药有限公司 | Sweet tea and preparation method thereof |
| CN103005091A (en) * | 2012-11-30 | 2013-04-03 | 李胜华 | Lithocarpus polysachyus rehd leaf instant tea powder and production process thereof |
| CN103120348A (en) * | 2013-03-11 | 2013-05-29 | 朱世超 | Honeysuckle flower distillate beverage and production method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王中奇: "《抗肿瘤中药临床应用手册》", 30 June 2013, 中国中医药出版社 * |
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Application publication date: 20160608 |