CN105636978A - 线性肽抗生素 - Google Patents

线性肽抗生素 Download PDF

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Publication number
CN105636978A
CN105636978A CN201480056420.XA CN201480056420A CN105636978A CN 105636978 A CN105636978 A CN 105636978A CN 201480056420 A CN201480056420 A CN 201480056420A CN 105636978 A CN105636978 A CN 105636978A
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CN
China
Prior art keywords
optionally substituted
alkyl
compound
formula
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480056420.XA
Other languages
English (en)
Chinese (zh)
Inventor
彼得·安德鲁·史密斯
塔克·柯伦·罗伯茨
罗伯特·I·希古奇
普拉苏纳·帕拉塞利
迈克尔·F·T·凯勒
詹姆斯·约翰·克劳福德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
RQx Pharmaceuticals Inc
Original Assignee
Genentech Inc
RQx Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, RQx Pharmaceuticals Inc filed Critical Genentech Inc
Publication of CN105636978A publication Critical patent/CN105636978A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
CN201480056420.XA 2013-08-14 2014-08-14 线性肽抗生素 Pending CN105636978A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361865980P 2013-08-14 2013-08-14
US201361865986P 2013-08-14 2013-08-14
US201361865982P 2013-08-14 2013-08-14
US61/865,982 2013-08-14
US61/865,980 2013-08-14
US61/865,986 2013-08-14
PCT/US2014/051151 WO2015023898A1 (en) 2013-08-14 2014-08-14 Linear peptide antibiotcs

Publications (1)

Publication Number Publication Date
CN105636978A true CN105636978A (zh) 2016-06-01

Family

ID=52468711

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480056420.XA Pending CN105636978A (zh) 2013-08-14 2014-08-14 线性肽抗生素

Country Status (9)

Country Link
US (1) US20160194358A1 (https=)
EP (1) EP3033352A4 (https=)
JP (1) JP2016528257A (https=)
KR (1) KR20160044512A (https=)
CN (1) CN105636978A (https=)
CA (1) CA2921082A1 (https=)
MX (1) MX2016001927A (https=)
RU (1) RU2016107436A (https=)
WO (1) WO2015023898A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110606825A (zh) * 2019-10-30 2019-12-24 成都海杰亚医药科技有限公司 一种制备吡啶-2-硫醇的方法
CN111233974A (zh) * 2019-11-12 2020-06-05 成都诺和晟泰生物科技有限公司 一种多肽类化合物、药物组合物及制备方法、应用
CN111978371A (zh) * 2019-05-22 2020-11-24 成都诺和晟泰生物科技有限公司 一种多肽类衍生物及其在医药领域的用途

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4067368A1 (en) 2016-06-01 2022-10-05 Athira Pharma, Inc. Compounds
RU2698328C1 (ru) * 2019-02-27 2019-08-26 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) Серебряные соли 5,6-диарил-4-[4-(ацетиламиносульфонил)фенил]-3,5-дигидропирроло[3,4-с]пиразол-3-онов, проявляющие противомикробную активность
JP2022542613A (ja) * 2019-07-30 2022-10-05 カール－フランツェンス－ウニベルシテート グラーツ ヒトａｔｇｌの阻害剤
CN116444378A (zh) * 2023-02-14 2023-07-18 广东优康精细化工有限公司 一种n-甲基异丙基胺的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017679A1 (en) * 1996-10-18 1998-04-30 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0932617T1 (en) * 1996-10-18 2002-06-30 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease
CN103159830B (zh) * 2011-12-15 2017-06-20 上海来益生物药物研究开发中心有限责任公司 脂肽类化合物
US8999922B2 (en) * 2012-02-16 2015-04-07 Rqx Pharmaceuticals, Inc. Linear peptide antibiotics

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017679A1 (en) * 1996-10-18 1998-04-30 Vertex Pharmaceuticals Incorporated Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PETER BUZDER-LANTOS等: "Substrate based peptide aldehyde inhibits bacterial type I signal peptidase", 《BIOORGANIC & MEDICINAL CHEMISTRY LETTERS》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111978371A (zh) * 2019-05-22 2020-11-24 成都诺和晟泰生物科技有限公司 一种多肽类衍生物及其在医药领域的用途
CN110606825A (zh) * 2019-10-30 2019-12-24 成都海杰亚医药科技有限公司 一种制备吡啶-2-硫醇的方法
CN111233974A (zh) * 2019-11-12 2020-06-05 成都诺和晟泰生物科技有限公司 一种多肽类化合物、药物组合物及制备方法、应用
WO2021093695A1 (en) * 2019-11-12 2021-05-20 Chengdu Sintanovo Biotechnologv Co., Ltd. Polypeptide compound, pharmaceutical composition, preparation method and application thereof
US11643436B2 (en) 2019-11-12 2023-05-09 Chengdu Sintanovo Biotechnology Co., Ltd. Polypeptide compound, pharmaceutical composition, preparation method and application thereof

Also Published As

Publication number Publication date
WO2015023898A1 (en) 2015-02-19
JP2016528257A (ja) 2016-09-15
KR20160044512A (ko) 2016-04-25
MX2016001927A (es) 2016-09-08
RU2016107436A3 (https=) 2018-05-22
EP3033352A4 (en) 2017-04-19
WO2015023898A8 (en) 2016-03-24
RU2016107436A (ru) 2017-09-19
CA2921082A1 (en) 2015-02-19
US20160194358A1 (en) 2016-07-07
EP3033352A1 (en) 2016-06-22

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Application publication date: 20160601