CN1056287C

CN1056287C - Traditional Chinese medicine for reducing blood-lipid and its preparing technology

Info

Publication number: CN1056287C
Application number: CN95113605A
Authority: CN
Inventors: 高培雄
Original assignee: Individual
Current assignee: Individual
Priority date: 1995-07-05
Filing date: 1995-07-05
Publication date: 2000-09-13
Anticipated expiration: 2015-07-05
Also published as: CN1125134A

Abstract

The present invention relates to a traditional Chinese medicine for curing hyperlipoidemia, which is prepared from the Chinese herbal medicines of fresh hawthorn fruit, licorice, red sage root, chrysanthemum flower, ligusticum root, etc. as a basic formula through scientific processing. Thus, the characteristics of traditional Chinese medicine decoctions are fully exerted, and the purposes of removing food stagnancy, reducing blood lipid, activating blood, removing blood stasis, improving blood circulation, promoting lipid metabolism and realizing balance are achieved. The traditional Chinese medicine has obvious therapeutic effect of reducing blood lipid and blood viscosity in human bodies, and at the same time, the traditional Chinese medicine has double cure and prevention action for resisting atherosclerosis and regulating the endocrine function of patients with obesity and hypertension.

Description

Chinese traditional medicines depressing lipid and preparation technology thereof

Content of the present invention belongs to the preparation technology field of medicine, relates to a kind of Chinese medicine and preparation technology thereof who is used for the treatment of hyperlipemia.

After the people entered person in middle and old age, because the body movement amount reduces, central nervous system, endocrine regulation disorder were higher fatty acid in addition, the excessive absorption of high protein diet and drinks, beverage, and lipid dysbolismus---hyperlipemia takes place easily.In case after the trouble hyperlipemia, the concentration of triglyceride and cholesterol will raise greatly in the blood, the lipid of this high concentration can be attached to the human body artery blood vessel wall, and progressively make its fibrosis, calcification, form atherosis speckle, so make the tremulous pulse hardening that narrows down, progressive or blocking blood flow suddenly, cause myocardial ischemia or blood supply in brain deficiency, even myocardial infarction or cerebral thrombosis, cerebral hemorrhage etc. occur.In recent years, the hypertension, coronary heart disease, atherosclerosis and the obesity person that cause because of hyperlipemia and high blood viscosity among the crowd sharply increase, and in big and medium-sized cities and western countries, this type of patient's sickness rate is then higher.To the treatment of hyperlipemia, with regard to medical science textbook and existing medicine, still not having a kind ofly can all have the Western medicine of significant curative effect to all hyperlipemias, and takes Western medicine for a long time and for human body certain toxic and side effects is arranged; And some Chinese medicine preparation also has limitation to the treatment of primary disease, exists long, many shortcomings such as effect is unstable and cure rate is low course of treatment.

The objective of the invention is to principle, the Chinese traditional medicines depressing lipid that a kind of curative effect height, short treating period is provided and has no side effect according to traditional Chinese medical science treatment must aim at the pathogenesis of disease.

Chinese traditional medicines depressing lipid of the present invention is that the invention designer passes through the summary of relevant medical literature and clinical practice for many years and develop on the basis of further investigation lipid metabolism to obtain, it is with Fructus Crataegi, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, Chinese herb medicines such as Rhizoma Chuanxiong are basic recipe, process by science, make it to give full play to the characteristics of Chinese herbs decoction, can reach the removing food stagnancy blood fat reducing, blood circulation promoting and blood stasis dispelling, improve blood circulation, impel lipid metabolism to realize equilibrated purpose, has the obvious treatment effect for reducing blood in human body in fat and blood viscosity, simultaneously for atherosclerosis, the endocrine function of adjusting obesity and patients with hypertension has double treatment and preventive effect.

The basic recipe composition (percentage by weight) that constitutes this Chinese traditional medicines depressing lipid is:

Fructus Crataegi 15～20% Radix Glycyrrhizaes 15～20%

Radix Salviae Miltiorrhizae 15～20% Flos Chrysanthemis 10～15%

Rhizoma Chuanxiong 10～15% Radix Puerariaes 10～15%

Hirudo 5～10%.Fructus Crataegi in the prescription, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong all have reduction T _C(cholesterol), T _G(triglyceride), the sedimentary effect in blood vessel wall of minimizing lipid; Flos Chrysanthemi, Radix Puerariae have tangible lipoid peroxidization resistant and strengthen the function of human body immunity; Radix Glycyrrhizae, Hirudo have anticoagulant effect preferably again.All medicines share, and can quicken the picked-up of liver to lipoprotein in the blood by suppressing the synthetic of endogenous cholesterol, promote that cholesterol transforms in liver or the drainage form, realize the balance adjustment of lipid metabolism.

In concrete the enforcement, medicine can be made into blood fat reducing electuary and capsule for descend of blood fat product by the basic recipe composition, its preparation method is as described below.

One, the preparation method of blood fat reducing electuary:

1. clean all medicines of prescription;

2. get Fructus Crataegi amount in the formula components 40%, the Radix Glycyrrhizae amount 40%, 40% and the Hirudo amount of Rhizoma Chuanxiong amount 100%, mix and pulverize the back and cross 100 mesh sieves, it is standby to make the medical material fine powder;

3. get all medicines of residue in the prescription in addition, 4～8 times of amounts of adding distil water were soaked after 30 minutes, boiled and extracted 2 hours, filtered then, and filtrate is deposited in addition; Medicinal residues part after filtering is converted in the distilled water of inserting 3 times of amounts again, boiled and extracted 1 hour, filter once more, and, residual liquid is extruded firmly squeezing of residue; Collect merging extracted twice liquid, leave standstill filtration, be concentrated into the thick paste shape through 80 ℃ of temperature, proportion about 1.5;

4. when the temperature for the treatment of thick paste shape medicine is reduced to 40 ℃ of left and right sides, add 0.2 ‰ saccharin sodium, after the stirring and dissolving, add again, stir and rub and make the shape soft material that sticks together by the prepared medical material fine powder of 2. processes; Soft material is crossed 20 mesh sieves granulate, dry through 60 ℃ of temperature again, at last the medicine grain is sub-packed in the plastics drug bag by every bag 15 gram, make suspension granule.

Two, the preparation method of capsule for descend of blood fat:

1. clean all medicines of prescription;

2. all medicines after will cleaning mix, pulverize, cross 40 mesh sieves, obtain the medicine coarse powder;

3. the medicine coarse powder is adorned percolation vat with 60% ethanol after moistening 24 hours, pour into above 60% ethanol about powder height 2cm in bucket, quiet soaking spent the night;

4. convert with the ethanol liquid of 8 times of medical material total amounts and insert in the quiet medicine that soaks later diafiltration, extraction; Collect percolate and reclaim ethanol, it is 1.5 that percolate is concentrated into proportion at normal temperatures, and spray drying obtains fine drug powder;

5. fine drug powder is incapsulated, every capsule grain contains medicated powder 0.4 gram, and per 60 is one bottle (box).

Case observation and curative effect:

Clinical case 80 examples (58 of men, 22 of woman) of observing altogether, the age, wherein hypercholesterolemia 23 examples accounted for 28.25% between 33～74 years old, and hypertriglyceridemia 57 examples account for 71.75%.

1. clinical symptoms: dizzy headache, feeling of oppression and pain in the chest, limbs fatigue, nervously breathe hard, abdominal distention poor appetite, stool are uncomfortable, light red tongue, greasy fur, stringy and rolling pulse or sliding number.

2. medicining mode: electuary every day 2～3 times, each a bag.Capsule every day 2～3 times, each two.Be 15 days a course of treatment.

3. criterion of therapeutical effect:

A. disease efficacy evaluation: symptom disappears substantially or transfers produce effects significantly well to; Symptom and picture of the tongue, pulse condition change to taking a turn for the better; Symptom and picture of the tongue, pulse condition no change are invalid.

B. objective indicator evaluation: by taking blood fat reducing electuary (capsule) after 15 days, T _CDrop-out value＞50% is a produce effects; Drop-out value is effective 20～40%; Drop-out value＜10% item is invalid; T _GDrop-out value＞50% is a produce effects; Drop-out value is effective 20～30%; Drop-out value＜20% is invalid.

4. curative effect: this organizes 80 routine case histories after treatment, produce effects 76 examples, effective 3 examples, invalid 1 example, and total effective rate is 98.75%, obvious effective rate is 95%.

Claims

1, a kind of Chinese medicine that is used for the treatment of hyperlipemia is characterized in that it is made by the Chinese medicine of following percentage by weight:

Fructus Crataegi 15～20% Radix Glycyrrhizaes 15～20%

Radix Salviae Miltiorrhizae 15～20% Flos Chrysanthemis 10～15%

Rhizoma Chuanxiong 10～15% Radix Puerariaes 10～15%

Hirudo 5～10%.

2, according to the technology of the described formulation blood fat reducing of claim 1 electuary, it is characterized in that comprising following preparation process:

2.1 clean all medicines of prescription;

2.2 get Fructus Crataegi amount in the formula components 40%, the Radix Glycyrrhizae amount 40%, 40% and the Hirudo amount of Rhizoma Chuanxiong amount 100%, mix and pulverize the back and cross 100 mesh sieves, it is standby to make the medical material fine powder;

2.3 get all medicines of residue in the prescription in addition, 4～8 times of amounts of adding distil water were soaked after 30 minutes, boiled and extracted 2 hours, filtered then, filtrate is deposited in addition; Medicinal residues after filtering part is converted in the distilled water of inserting 3 times of amounts again, is boiled and extracted 1 hour, filter once more, and with firmly squeezing of residue, make residual liquid press by; Collect merging extracted twice liquid, leave standstill filtration, be concentrated into the thick paste shape through 80 ℃ of temperature, proportion about 1.5;

2.4 treat to reduce to about 40 ℃ through the medicine temperature after 2.3 processes, add 0.2% saccharin sodium, after the stirring and dissolving, add again by the prepared medical material fine powder of 2.2 processes, stir and rub and make the shape soft material that sticks together; Soft material is crossed 20 mesh sieves granulate, dry through 60 ℃ of temperature again, at last the medicine grain is sub-packed in the plastics drug bag by every bag 15 gram.

3, according to the technology of the described formulation capsule for descend of blood fat of claim 1 agent, it is characterized in that comprising following preparation process:

3.1 clean all medicines of prescription;

3.2 all medicines after will cleaning mix, pulverize, cross 40 mesh sieves, obtain the medicine coarse powder;

3.3 the medicine coarse powder is adorned percolation vat with 60% ethanol after moistening 24 hours, in bucket, to pour into above 60% ethanol about powder height 2cm, quiet soaking spent the night;

3.4 will convert diafiltration in the ethanol liquid of inserting 8 times of medical material total amounts, extraction through the medicine after 3.3 processes; Collect percolate and reclaim ethanol, it is 1.5 that percolate is concentrated into proportion at normal temperatures, and spray drying obtains fine drug powder;

3.5 fine drug powder is incapsulated, and every capsule grain contains medicated powder 0.4 gram, every bottle (box) 60.