CN105617117A - Pill for treating mixed angina pectoris and preparation method thereof - Google Patents

Abstract

The invention discloses a pill for treating mixed angina pectoris. The pill comprises the following raw herbs in parts by weight: 20-30 parts of folium ginkgo, 5-15 parts of fructus schizandrae, 5-15 parts of A. venetum L., 6-16 parts of maize, 10-20 parts of ganoderma, 15-25 parts of herba dendrobii, 1-5 parts of radix salviae miltiorrhizae, 8-20 parts of herba centellae, 10-15 parts of porcine heart, 2-6 parts of lycopene, 10-30 parts of soybean, 20-40 parts of slender shad and 6-13 parts of ramulus cinnamomi. One of the purposes of the invention is to provide the pill for treating mixed angina pectoris, and the pill has the characteristics of no stimulation, good effect, and high acceptability. The pill adopts the locally common herbs as the raw materials, and is prepared according to a special processing technique.

Description

A kind of pill and its preparation method treating mixed angina pectoris

Technical field

The present invention relates to traditional Chinese medicine field, especially relate to a kind of pill and its preparation method for the treatment of mixed angina pectoris.

Background technology

Stenocardia (anginapectoris) is coronary insufficiency, caused by cardiac muscle ischemia sharply and anoxic taking clinical syndrome for mainly showing of outbreak property pectoralgia or chest discomfort. Stenocardia is the pain that heart ischemia reflexes to body surface and feels, feature is shirtfront paroxysmal, squeezing property pain, can with other symptoms, pain is mainly positioned at breastbone rear portion, can be radiated to pareordia and upper left limb, work or excited often occur, outbreak continues 3��5 minutes every time, can a few days once, it is possible to one is for several times, has a rest or disappears with after nitrate esters preparation. This disease is more common in the male sex, most more than 40 years old, tired, excited, full eat, catches cold, rainy weather, acute circulatory failure etc. are common inducement.

Clinical manifestation show as more vexed pain, squeezing property pain or breastbone after, throat portion tighten sense, some patient only has uncomfortable in chest, typicalness stenocardia and non-typicalness stenocardia can be divided into: 1. typical case's angina pectoris symptom: what occur suddenly is positioned on mesosternum section or the squeezing after stage casing, vexed swollen property or suffocating property pain, also major part pareordia may be involved, can be radiated to inside before left shoulder, upper left limb, reach the third finger and little finger of toe, occasionally can with dying sense, often forcing patient to stop action immediately, severe one is also perspired. Pain lasts 1��5 minute, rarely exceeds 15 minutes; Have a rest or containing taking pannonit, pain in 1��2 minute, (rarely exceed 5 minutes) disappear. Be everlasting tired, excited (angry, anxious, be overexcited), catch cold, full food, smoking time occur, anaemia, tachycardia or shock also can be brought out. 2. atypical angina pectoris symptom: pain can be positioned at inferior segment sternotomy, left pareordia or epigastrium, it is radiated to neck, lower jaw, left omoplate portion or right front chest, pain can disappear or only have left front chest discomfort, stuffy sense very soon, is common in old patient or diabetic subject.

Within 1985, MASERI proposes this title of mixed angina pectoris, is characterized in that stenocardia had both occurred patient when myocardium requirementing keto quantity increases, also can at myocardium requirementing keto quantity without stenocardia occurs when obviously increasing. Namely these patients simultaneously and deposit fatigue and spontaneous angina pectoris, and in a stenocardia is shown effect, myocardial consumption of oxygen can be had simultaneously to increase and reduce by two kinds of factors participations with coronary artery blood supply. The pathogenesis determining mixed angina pectoris is: (1), there is coronary artery stationarity stenotic lesion. Namely the coronary artery of more than is had at least to have criticality to fix narrow, limit the reserve capabillity of maximum coronary artery, even if without in any additional coronary flow minimizing situation, exceed certain labour's limit or cardiac muscle oxygen needs level, namely produce fatigue stenocardia. (2), there is dynamic property obstruction or other factor making the of short duration minimizing of coronary flow, such as coronary vasospasm or contraction etc. If coronary flow reduces, degree does not weigh, then stenocardia can occur under the labour's limit that usually can tolerate; If Oligemia is to lower than level during tranquillization, then spontaneous angina occurring.

Therefore, mixed angina pectoris is attributable to stationarity in various degree or the result of the narrow acting in conjunction of dynamic property. Can show as stenocardia on clinical can separately caused by myocardial consumption of oxygen increases, or separately by caused by the unexpected minimizing of blood supply of cardiac muscle, or outbreak has two kinds of factors simultaneously concurrently and participate in. Its principle of reatment should comprise and uses vasodilator to prevent vasospasm and contraction and reduce myocardial consumption of oxygen, it is to increase exercise tolerance these two aspects.

Authorization Notice No. CN103550428B(application number 201310506553.X) Chinese patent literature provide a kind of externally applied agent treating stenocardia, it is characterized in that, this externally applied agent is made up of Radix Aconiti Preparata, Trogopterus Dung, the red sage root, cattail pollen, leech and borneol six kinds of components; The weight part of each component is respectively: Radix Aconiti Preparata 10��15 parts, Trogopterus Dung 20��30 parts, the red sage root 15��20 parts, cattail pollen 10��15 parts, leech 5��10 parts, borneol 3��5 parts. Authorization Notice No. CN102133288B(application number 201010520265.6) Chinese patent literature provide a kind of Chinese medicine preparation treating stenocardia, it is characterised in that be made up of the raw material of following weight part number: the red sage root 6 parts, Ligusticum wallichii 4 parts, 3 parts, peach kernel, radix bupleuri 4 parts, Fructus Aurantii 4 parts, Radix Glycyrrhizae Preparata 3 parts and cassia twig 4 parts.

It thus is seen that Chinese medicine has invigorating QI and tranquilization, nourishes heart in treatment mixed angina pectoris, effect of promoting blood circulation to remove blood stasis, coronary circulation-promoting pain-relieving, but in patent documentation, it does not have the pill of special for treating mixed angina pectoris.

Summary of the invention

For the reason that above-mentioned mixed angina pectoris is formed, an object of the present invention is to provide a kind of pill treating mixed angina pectoris, have non-stimulated, effective, feature easy to patients, the present invention adopts Chinese medicinal materials comparatively common in the localities as raw material, becomes through special complete processing manufacture.

Another object of the present invention is just to provide the preparation method of above-mentioned pill.

The above-mentioned purpose of the present invention is achieved through the following technical solutions:

Treating a pill for mixed angina pectoris, the weight proportion of each bulk drug is as follows, is weight part:

Ginkgo Leaf 20-30 shizandra berry 5-15 kendir 5-15

Corn 6-16 glossy ganoderma 10-20 stem of noble dendrobium 15-25

Red sage root 1-5 Herba Centellae 8-20 Pigs Hearts 10-15

Lyeopene 2-6 soybean 10-30 strangles fish 20-40

Cassia twig 6-13.

The pill of aforementioned therapies mixed angina pectoris, it is preferable that scheme, the weight proportion of each bulk drug is as follows, is weight part:

Ginkgo Leaf 23-28 shizandra berry 8-13 kendir 8-13

Corn 10-12 glossy ganoderma 13-18 stem of noble dendrobium 18-23

Red sage root 2-4 Herba Centellae 14-16 Pigs Hearts 11-14

Lyeopene 3-5 soybean 15-25 strangles fish 25-35

Cassia twig 8-10.

The pill of aforementioned therapies mixed angina pectoris, better preferred scheme, the weight proportion of each bulk drug is as follows, is weight part:

Ginkgo Leaf 25 shizandra berry 11 kendir 10

Corn 11 glossy ganoderma 15 stem of noble dendrobium 20

The red sage root 3 Herba Centellae 15 Pigs Hearts 13

Lyeopene 4 soybean 20 Le fish 30

Cassia twig 9.

The preparation method of the pill for the treatment of mixed angina pectoris, step is as follows:

(1) Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, the stem of noble dendrobium, the red sage root, Herba Centellae are cleaned together with cassia twig, soak 20-40 hour with the light-coloured vinegar of Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, the stem of noble dendrobium, the red sage root, Herba Centellae and cassia twig weight 2-5 times, soaked bulk drug strainer is taken out, it is placed in the iron pot burning heat and repeatedly turns over stir-fry 12-24 minute, dry in the air cool, grind to form smalls, cross 80-120 order sieve stand-by;

(2) corn being ground peeling to be together placed in transparent Glass Containers with soybean, add the warm water of 40-50 DEG C, it is stand-by that sealing soaks 2-4 hour;

(3) Le fish is cleaned the block being cut into nail size, mix thoroughly with soy sauce, cooking wine, onion parts, ginger splices and Chinese prickly ash, with preservative film parcel, place 28-48 minute, take out and strangle fish, putting into edible oil in the hot pot dryouied, the consumption of edible oil is 10-20 times that strangles fish weight, edible oil is fired surrounding and plays cigarette, put into the Le fish pickled, fried 2-6 time repeatedly, dry in the air to crisp, grind to form smalls stand-by;

(4) being placed in marmite by clean for Pigs Hearts, add Pigs Hearts weight 3-7 light salt brine doubly, big fire is boiled, and puts into step (2) gained corn and soybean, and fire of larding speech with literary allusions is slow to be simmered 70-90 minute, filtration, and filtrate is stand-by, takes out Pigs Hearts, cuts into slices and dry on fire, grind broken stand-by;

(5) step (1), (3) and (4) gains are mixed even, decoct to boil and stir into thick cream and add the honey and Lyeopene refined, be prepared into pill according to the complete processing of pill.

The preparation method of above-mentioned pill, step (1) Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, the stem of noble dendrobium, the red sage root, Herba Centellae and cassia twig weight 3-4 light-coloured vinegar doubly soaks 25-35 hour (preferred, to soak 30 hours with the light-coloured vinegar of Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, the stem of noble dendrobium, the red sage root, Herba Centellae and cassia twig weight 3.5 times).

The preparation method of above-mentioned pill, step (1) is placed in the hot iron pot of burning and repeatedly turns over stir-fry 16-20 minute (preferred, to be placed in the hot iron pot of burning and repeatedly turn over stir-fry 18 minutes).

The preparation method of above-mentioned pill, step (2) adds the warm water of 43-48 DEG C, and sealing is soaked 2.5-3.5 hour stand-by (preferably, adding the warm water of 45 DEG C, it is stand-by that sealing soaks 3 hours).

The preparation method of above-mentioned pill, step (3) preservative film parcel, places 34-42 minute (preferred, with preservative film parcel, to place 38 minutes).

The preparation method of above-mentioned pill, the consumption of step (3) edible oil is 13-18 times (preferred, the consumption of edible oil is 15 times that strangle fish weight) strangling fish weight.

The preparation method of above-mentioned pill, step (4) adds Pigs Hearts weight 4-6 light salt brine (preferred, to add the light salt brine of Pigs Hearts weight 5 times) doubly.

For making this medicine reach optimum therapeuticing effect, getting pill of the present invention 1, sooner or later each 5 days is once a course for the treatment of every time, with good conditionsi can take always.

This pill is remarkable to treatment mixed angina pectoris effect, has rapid-action, the feature that curative ratio is high, using this pill not have the sensation of any discomforts, during taking, stomach does not have any excitements, and the present invention selects local common medicinal material more, cheap, alleviate the economical load of patient.

The pharmacological effect of each bulk drug is respectively:

Ginkgo Leaf: Ginkgo Leaf is the dry leave of Ginkgoaceae plant Ginkgo biloba GinkgobilobaL.. Autumn gathers when leaf is still green, dry in time. Have promoting blood circulation and removing blood stasis, remove obstruction in channels to relieve pain, hold back lung and relieving asthma, change turbid effect falling fat. For obstruction of collaterals by blood stasis, Obstruction of qi in the chest and cardialgia, stroke hemiplegia, the deficiency syndrome of the lung is coughed and is breathed heavily, hyperlipidaemia.

Shizandra berry: be famous Chinese medicine, its fruit is containing schizandrin (SchisandrinC23H3206) and vitamins C, resin, tannin and a small amount of carbohydrate. There is the effect astringeed the lung to stop cough, nourish puckery essence, antidiarrheal only sweat. Its leaf, fruit can extract perfume oil. Planting benevolence and contain fatty oil, oil expression can make industrial raw material, lubricating oil. Stem hide fiber is pliable and tough, can supply rope. Function cures mainly: hold back lung, and nourshing kidney is promoted the production of body fluid, and receives sweat, puckery essence. Controlling the deficiency syndrome of the lung to breath with cough, dry is done thirsty, and spontaneous perspiration, night sweat, internal lesion caused by overexertion is thin thin, nocturnal emission involuntary emission, rushes down dysentery of a specified duration for a long time.

Kendir: root of Apocynum venetum L. decoction has cardiotonic. Folium Apocyni Veneti medicinal extract has calmness, anticonvulsant action, and have stronger diuresis, reduce blood fat, immunity moderation, anti-ageing and suppress the effect such as influenza virus, hypertension patient is had certain adjuvant treatment effect. Nature and flavor: the property of medicine is sweet, bitter, cool. Return Liver Channel. Suppressing liver-YANG, clearing away heat and promoting diuresis. Can treat and have a dizzy spell and oedema, dysuria.

Corn: corn is the health-care good product in coarse food grain, the health of human body is rather favourable: the compositions such as vitamin B6 in corn, nicotinic acid, there is the characteristic that stimulating gastrointestinal is wriggled, accelerated defecate, can prevent treating constipation, stomach trouble, enteritis, intestinal cancer etc. Corn rich vitamin C, dextrinosan etc., have longevity, beautification function. Nutritive substance contained by maize point has enhancing human metabolism, adjustment nervous function. Can play and make skin delicacy smooth, suppress, delay wrinkle generation effect. Corn has in tune effect of appetizing and reducing blood-fat, reduction serum cholesterol. Prophylaxis of tumours effect: corn contains Methionin, trace element-selenium, has the effect of prophylaxis of tumours. Corn is also containing abundant vitamin B group, nicotinic acid etc., and to protection nerve conduction and gastrointestinal function, prevention vitamin B1 deficiency, myocarditis are effective.

Glossy ganoderma: glossy ganoderma is also known as Lin Zhongling, fine jade treasure (formal name used at school: GanodermaLucidumKarst), best with the glossy ganoderma of growth in woods. Profile is umbrella shape, cap kidney shape, semicircle or subcircular, is the sporophore of polyporaceae fungi glossy ganoderma. There is invigorating QI and tranquilization, relieving cough and asthma effect, coughing breathe heavily for dizzy egersis, shortness of breath and palpitation, neurasthenia, empty labor, promote longevity, this taste is sweet can mend, property flat temperature partially, enter lung channel, replenishing and restoring lung-QI, warming lung and reducing phlegm, relieving cough and asthma, often can control phlegm and retained fluid card, see the cold cough of shape, phlegm many asthma person, especially that phlegm-damp type or asthenic cold type curative effect is better.

The stem of noble dendrobium: the stem of noble dendrobium (formal name used at school: DendrobiumnobileLindl), has another name called lofty or bottomless palpus, bracketplant, Lin Lan, taboo life, Jin Chai flower etc. Stem is upright, and meat shape is plump, and slightly flat is cylindrical, long 10 ~ 60 centimetres, slightly reaches 1.3 centimetres. Medicinal plant, nature and flavor are sweet light micro-salty, cold, return stomach, kidney, lung channel. Reinforcing stomach reg fluid is nourishing Yin and clearing heat. Hindering body fluid deficiency for the moon, dry polydipsia, food is few retches, and abnormal heat after being ill, order is secretly failed to understand.

The red sage root: the red sage root, Chinese medicine name. For the dry root welding technology of labiate red sage root SalviamiltiorrhizaBge.. Spring, Qiu Erji excavate, and remove silt, dry. Whole nation most area has distribution. Having promoting blood circulation to remove blood stasis, inducing meastruation to relieve menalgia, clear away heart-fire relieving restlessness, and cool blood disappears effect of carbuncle. For Obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, lump in the abdomen lump in the abdomen is gathered, hot numbness pain, dysphoria and insomnia, and menoxenia, dysmenorrhoea is through closing, and sore swells and ache.

Herba Centellae: be dry full grass or the whole herb with root of dicotyledons umbelliferae Herba Centellae. Composition: containing three terpene components of multiple ��-resinoid alcohol type, wherein have centella asiatica glucoside, join withered Buddhist nun's glycosides, the withered Buddhist nun's glycosides of different ginseng, asiaticoside, Bo Remo glycosides, broken hot rice glycosides and Brahmic acid etc., and motor asiatic acid. The property of medicine: bitter, pungent, cold. Return liver, spleen, kidney channel. Function cures mainly: clearing heat and detoxicating, inducing diuresis and reducing edema. It is the long-lived medicine of Oriental, can refresh oneself by benefit brain. Research shows to have nourishing, anti-inflammatory, healing wound, diuresis defaecation and calm effect. Leprosy, ulcer is also effective in cure, blood purification and immunizing power there are is activation, because it can stimulate the replacement of deep skin cell. It is neural nourishing agent, can improve memory, alleviate mental fatigue; Blood pressure also can fall, treatment hepatopathy etc.

Pigs Hearts: Pigs Hearts energy bushing, treatment palpitaition, heartbeat, palpitation. According to modern nutriology analytical proof, Pigs Hearts is the very abundant food of a kind of nutrition. It contains protein, fat, calcium, phosphorus, iron, VITMAIN B1, Lin Suanna Vitamin B2 Sodium Phosphate, vitamin c and nicotinic acid etc., and this is to reinforcement myocardial nutrition, and strengthening myocardial contraction has very big effect. Clinical relevant information illustrates, many cardiac disorders are with whether the motility of cardiac muscle normally has close relationship. Therefore, though Pigs Hearts can not improve heart organic disease completely, but cardiac muscle can be strengthened, cardiac nutrition, be conducive to recovery from illness that is functional or nervosa heart disease. Nutritive ingredient list: Pigs Hearts, containing compositions such as protein, fat, VitB1, riboflavin, nicotinic acids, has nutrition blood, the action and efficacy of tranquilizing by nourishing the heart: qi-restoratives, arresting convulsion of calming the nerves, nourishes heart and enrich blood. Cure mainly: insomnia of having a guilty conscience, palpitation with fear, spontaneous perspiration, absent-minded disease such as grade. Should eat: the hidrosis that is suitable for having a guilty conscience, spontaneous perspiration, palpitation with fear are in a trance, palpitation, insomnia and dreamful sleep people eat; Suitable schizophrenia, insane pain, hysteria patient eat.

Lyeopene: protect cardiovascular: in the generation and development process of atherosclerosis, the lipoprotein oxidation in tunica intima is a key factor. Lyeopene plays an important role in reduction lipoprotein oxidation. It is reported, oral natural Lyeopene, can make serum cholesterol be down to 5.20 mmoles/liter below, Lyeopene is for preventing and treating hypercholesterolemia and hyperlipidemia, it is possible to slow down the development of cardiovascular disorder. The different physiological roles such as the asthma that Lyeopene also has preventing osteoporosis, fall blood pressure, alleviate motion causes.

Soybean: soybean fat also has very high nutritive value, containing a lot of unsaturated fatty acids in this kind of fat, it is easy to digested. And soybean fat can stop the absorption of cholesterol, so soybean is for arteriosclerosis patient, it it is a kind of desirable nutritious prod. The good digestion of promotion and excretion solid waste are had very important effect by the food fibre in bean dregs. Supplementary fibre element in appropriate amount, can make the food in enteron aisle increase deliquescing, promote intestines peristalsis, thus the row's of accelerating just speed, prevent constipation and reduce the risk of intestinal cancer. Meanwhile, food fibre have significantly reduce plasma cholesterol, regulate the function such as gastrointestinal function and insulin level.

Strangle fish: for Pacific herring section Chinese herring fish belongs to the meat that animal strangles fish. Composition: meat is containing protein, fatty, calcium, phosphorus, iron, riboflavin, nicotinic acid and VitB1. The property of medicine: sweet, flat. Return spleen, stomach warp. Function cures mainly: spleen benefiting and stimulating the appetite, feels at ease to repose. Curing mainly insufficiency of the spleen diarrhoea, maldigestion, mouth of keeping silent is not eaten, severe palpitation.

Cassia twig:, fever with chills etc. Its nature and flavor are pungent, sweet, temperature, enter lung, the heart, bladder warp, it is cure mainly medicine in the conventional temperature of interior cold, there is the effect mending Yuanyang, promoting blood circulation, warming the spleen and stomach, normal with invigorating the liver and kidney medicine, fill blood medicine compatibility, treat insufficiency of kidney-YANG, decline of the fire from the gate of life, the cold arteries and veins of limb micro-, treat coldness and pain in the epigastrium, arthritis pain in the back with medicine compatibility in other temperature, there is the effect of significantly analgesia and anti-cancer and cancer-preventing. The existing various wind oils medicine that drives is if menthocamphorate, rheumatism oil etc. are all containing osmanthus oil component. Function: cassia twig energy sweating solution flesh, warming meridians and promoting circulation of qi, supporing yangization gas, dispersing cold for relieving pain. Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Through closing dysmenorrhoea; Abdominal mass lumps; The obstruction of qi in the chest; Palpitaition; Phlegm and retained fluid; Dysuria. For common cold caused by wind-cold, coldness and pain in the epigastrium, blood is cold through closing, and arthralgia, phlegm and retained fluid, oedema, palpitaition, to globefish.

Pill of the present invention debates the principle of disease treatment based on traditional Chinese medicine. The medicine of existing treatment mixed angina pectoris and food in the medicinal material selected, it is improved again the bulk drug of body immunity, heart tonifying and tranquilizing, promoting blood circulation to remove blood stasis, coronary circulation-promoting pain-relieving, the bulk drug of various effect cooperatively interacts preparation cost invention together for the pill of external application, and treatment mixed angina pectoris is had fabulous therapeutic action.

Embodiment

The technical scheme of the present invention is described in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

Embodiment 1 treats the pill of mixed angina pectoris, takes off the bulk drug stating weight proportion and is prepared from (getting 10g for every part):

Ginkgo Leaf 20 portions of shizandra berry, 5 portions of kendirs 5 parts

Corn 6 portions of glossy ganodermas, 10 parts of stems of noble dendrobium 15 parts

The red sage root 1 part of Herba Centellae, 8 parts of Pigs Hearts 10 parts

Fish 20 parts strangled by Lyeopene 2 portions of soybean 10 parts

Cassia twig 6 parts.

The preparation method of the pill of above-mentioned treatment mixed angina pectoris, step is:

(1) Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, Gorgon fruit, the red sage root, Herba Centellae are cleaned together with cassia twig, 20 hours are soaked with the light-coloured vinegar of Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, Gorgon fruit, the red sage root, Herba Centellae and cassia twig weight 2 times, soaked bulk drug strainer is taken out, it is placed in the iron pot burning heat and repeatedly turns over stir-fry 12 minutes, dry in the air cool, grind to form smalls, cross 80 order sieves stand-by;

(2) corn being ground peeling to be together placed in transparent Glass Containers with soybean, add the warm water of 40 DEG C, it is stand-by that sealing soaks 2 hours;

(3) Le fish is cleaned the block being cut into nail size, mix thoroughly with soy sauce, cooking wine, onion parts, ginger splices and Chinese prickly ash, with preservative film parcel, place 28 minutes, take out and strangle fish, putting into edible oil in the hot pot dryouied, the consumption of edible oil is 10 times that strangle fish weight, edible oil is fired surrounding and plays cigarette, put into the Le fish pickled, fried 2 times repeatedly, dry in the air to crisp, grind to form smalls stand-by;

(4) being placed in marmite by clean for Pigs Hearts, add the light salt brine of Pigs Hearts weight 3 times, big fire is boiled, and puts into step (2) gained corn and soybean, and fire of larding speech with literary allusions is slow to be simmered 70 minutes, filters, and filtrate is stand-by, and taking-up Pigs Hearts, cuts into slices and dry on fire, grind broken stand-by;

(5) step (1), (3) and (4) gains are mixed even, decoct to boil and stir into thick cream and add the honey and Lyeopene refined, be prepared into pill according to the complete processing of pill.

Embodiment 2 treats the pill of mixed angina pectoris, takes off the bulk drug stating weight proportion and is prepared from (getting 15g for every part):

Ginkgo Leaf 30 portions of shizandra berry, 15 portions of kendirs 15 parts

Corn 16 portions of glossy ganodermas, 20 parts of stems of noble dendrobium 25 parts

The red sage root 5 parts of Herba Centellaes, 20 parts of Pigs Hearts 15 parts

Fish 40 parts strangled by Lyeopene 6 portions of soybean 30 parts

Cassia twig 13 parts.

The preparation method of the pill of above-mentioned treatment mixed angina pectoris, step is:

(1) Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, Gorgon fruit, the red sage root, Herba Centellae are cleaned together with cassia twig, 40 hours are soaked with the light-coloured vinegar of Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, Gorgon fruit, the red sage root, Herba Centellae and cassia twig weight 5 times, soaked bulk drug strainer is taken out, it is placed in the iron pot burning heat and repeatedly turns over stir-fry 24 minutes, dry in the air cool, grind to form smalls, cross 120 order sieves stand-by;

(2) corn being ground peeling to be together placed in transparent Glass Containers with soybean, add the warm water of 50 DEG C, it is stand-by that sealing soaks 4 hours;

(3) Le fish is cleaned the block being cut into nail size, mix thoroughly with soy sauce, cooking wine, onion parts, ginger splices and Chinese prickly ash, with preservative film parcel, place 48 minutes, take out and strangle fish, putting into edible oil in the hot pot dryouied, the consumption of edible oil is 20 times that strangle fish weight, edible oil is fired surrounding and plays cigarette, put into the Le fish pickled, fried 6 times repeatedly, dry in the air to crisp, grind to form smalls stand-by;

(4) being placed in marmite by clean for Pigs Hearts, add the light salt brine of Pigs Hearts weight 7 times, big fire is boiled, and puts into step (2) gained corn and soybean, and fire of larding speech with literary allusions is slow to be simmered 90 minutes, filters, and filtrate is stand-by, and taking-up Pigs Hearts, cuts into slices and dry on fire, grind broken stand-by;

(5) step (1), (3) and (4) gains are mixed even, decoct to boil and stir into thick cream and add the honey and Lyeopene refined, be prepared into pill according to the complete processing of pill.

Typical case one: Zhu XX, man, 55 years old, Distributions in Liaocheng of Shandong Province personage, peasant, smokes for a long time, love is drunk, and suffers from coronary heart disease more than 4 years, draws shoulder because of sense pareordia shouting pain prominent during morning exercises, pain and carry on the back and be outbreak property, from taking SUXIAO JIUXIN WAN remission after about ten minutes, patient is delivered to hospital by son, and comprehensively checks, Electrocardioscopy finds that there is transient myocardial ischemia phenomenon, making a definite diagnosis as mixed angina pectoris, doctor advised takes pill of the present invention.

Taking embodiment 2 gained pill, take 5 days, symptom is obviously improved, and fully recovers after 10 days, and general malaise symptom disappears, and Electrocardioscopy is normal, follows up a case by regular visits to and does not recur for 1 year.

Embodiment 3: the pill for the treatment of mixed angina pectoris, take off the bulk drug stating weight proportion and it is prepared from (getting 20g for every part):

Ginkgo Leaf 23 portions of shizandra berry, 8 portions of kendirs 8 parts

Corn 10 portions of glossy ganodermas, 13 parts of stems of noble dendrobium 18 parts

The red sage root 2 parts of Herba Centellaes, 14 parts of Pigs Hearts 11 parts

Fish 25 parts strangled by Lyeopene 3 portions of soybean 15 parts

Cassia twig 8 parts.

The preparation method of the pill of above-mentioned treatment mixed angina pectoris, step is:

(1) Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, Gorgon fruit, the red sage root, Herba Centellae are cleaned together with cassia twig, 25 hours are soaked with the light-coloured vinegar of Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, Gorgon fruit, the red sage root, Herba Centellae and cassia twig weight 3 times, soaked bulk drug strainer is taken out, it is placed in the iron pot burning heat and repeatedly turns over stir-fry 16 minutes, dry in the air cool, grind to form smalls, cross 90 order sieves stand-by;

(2) corn being ground peeling to be together placed in transparent Glass Containers with soybean, add the warm water of 40-50 DEG C, it is stand-by that sealing soaks 2.5 hours;

(3) Le fish is cleaned the block being cut into nail size, mix thoroughly with soy sauce, cooking wine, onion parts, ginger splices and Chinese prickly ash, with preservative film parcel, place 34 minutes, take out and strangle fish, putting into edible oil in the hot pot dryouied, the consumption of edible oil is 13 times that strangle fish weight, edible oil is fired surrounding and plays cigarette, put into the Le fish pickled, fried 3 times repeatedly, dry in the air to crisp, grind to form smalls stand-by;

(4) being placed in marmite by clean for Pigs Hearts, add the light salt brine of Pigs Hearts weight 4 times, big fire is boiled, and puts into step (2) gained corn and soybean, and fire of larding speech with literary allusions is slow to be simmered 75 minutes, filters, and filtrate is stand-by, and taking-up Pigs Hearts, cuts into slices and dry on fire, grind broken stand-by;

(5) step (1), (3) and (4) gains are mixed even, decoct to boil and stir into thick cream and add the honey and Lyeopene refined, be prepared into pill according to the complete processing of pill.

Embodiment 4 treats the pill of mixed angina pectoris, takes off the bulk drug stating weight proportion and is prepared from (getting 25g for every part):

Ginkgo Leaf 28 portions of shizandra berry, 13 portions of kendirs 13 parts

Corn 12 portions of glossy ganodermas, 18 parts of stems of noble dendrobium 23 parts

The red sage root 4 parts of Herba Centellaes, 16 parts of Pigs Hearts 14 parts

Fish 35 parts strangled by Lyeopene 5 portions of soybean 25 parts

Cassia twig 10 parts.

The preparation method of the pill of above-mentioned treatment mixed angina pectoris, step is:

(1) Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, Gorgon fruit, the red sage root, Herba Centellae are cleaned together with cassia twig, 35 hours are soaked with the light-coloured vinegar of Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, Gorgon fruit, the red sage root, Herba Centellae and cassia twig weight 4 times, soaked bulk drug strainer is taken out, it is placed in the iron pot burning heat and repeatedly turns over stir-fry 20 minutes, dry in the air cool, grind to form smalls, cross 110 order sieves stand-by;

(2) corn being ground peeling to be together placed in transparent Glass Containers with soybean, add the warm water of 48 DEG C, it is stand-by that sealing soaks 3.5 hours;

(3) Le fish is cleaned the block being cut into nail size, mix thoroughly with soy sauce, cooking wine, onion parts, ginger splices and Chinese prickly ash, with preservative film parcel, place 42 minutes, take out and strangle fish, putting into edible oil in the hot pot dryouied, the consumption of edible oil is 18 times that strangle fish weight, edible oil is fired surrounding and plays cigarette, put into the Le fish pickled, fried 5 times repeatedly, dry in the air to crisp, grind to form smalls stand-by;

(4) being placed in marmite by clean for Pigs Hearts, add Pigs Hearts weight 3-7 light salt brine doubly, big fire is boiled, and puts into step (2) gained corn and soybean, and fire of larding speech with literary allusions is slow to be simmered 85 minutes, filtration, and filtrate is stand-by, takes out Pigs Hearts, cuts into slices and dry on fire, grind broken stand-by;

(5) step (1), (3) and (4) gains are mixed even, decoct to boil and stir into thick cream and add the honey and Lyeopene refined, be prepared into pill according to the complete processing of pill.

Model case two: poplar XX, female, 68 years old, smoking frequent when patient is young, and also frequent especially, the severe smoking cessation breathed heavily because coughing when 55 years old, because of overworked processus aboralis sense ambition severe pain, if thorn is such as strand, localized pain, sensation of oppression over the chest with shortness of breath, dynamic then more so, nervous, come hospital to check, it is coronary heart disease and angina pectoris outbreak through Electrocardioscopy.

Taking embodiment 4 gained pill, take 10 days, symptom is obviously improved, and fully recovers after 15 days, and general malaise symptom disappears, and Electrocardioscopy is normal, follows up a case by regular visits to and does not recur for 1 year.

Embodiment 5: the pill for the treatment of mixed angina pectoris, take off the bulk drug stating weight proportion and it is prepared from (getting 30g for every part):

Ginkgo Leaf 25 portions of shizandra berry, 11 portions of kendirs 10 parts

Corn 11 portions of glossy ganodermas, 15 parts of stems of noble dendrobium 20 parts

The red sage root 3 parts of Herba Centellaes, 15 parts of Pigs Hearts 13 parts

Fish 30 parts strangled by Lyeopene 4 portions of soybean 20 parts

Cassia twig 9 parts.

The preparation method of the pill of above-mentioned treatment mixed angina pectoris, step is:

(1) Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, Gorgon fruit, the red sage root, Herba Centellae are cleaned together with cassia twig, 30 hours are soaked with the light-coloured vinegar of Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, Gorgon fruit, the red sage root, Herba Centellae and cassia twig weight 3.5 times, soaked bulk drug strainer is taken out, it is placed in the iron pot burning heat and repeatedly turns over stir-fry 18 minutes, dry in the air cool, grind to form smalls, cross 100 order sieves stand-by;

(2) corn being ground peeling to be together placed in transparent Glass Containers with soybean, add the warm water of 45 DEG C, it is stand-by that sealing soaks 3 hours;

(3) Le fish is cleaned the block being cut into nail size, mix thoroughly with soy sauce, cooking wine, onion parts, ginger splices and Chinese prickly ash, with preservative film parcel, place 38 minutes, take out and strangle fish, putting into edible oil in the hot pot dryouied, the consumption of edible oil is 15 times that strangle fish weight, edible oil is fired surrounding and plays cigarette, put into the Le fish pickled, fried 4 times repeatedly, dry in the air to crisp, grind to form smalls stand-by;

(4) being placed in marmite by clean for Pigs Hearts, add the light salt brine of Pigs Hearts weight 5 times, big fire is boiled, and puts into step (2) gained corn and soybean, and fire of larding speech with literary allusions is slow to be simmered 80 minutes, filters, and filtrate is stand-by, and taking-up Pigs Hearts, cuts into slices and dry on fire, grind broken stand-by;

(5) step (1), (3) and (4) gains are mixed even, decoct to boil and stir into thick cream and add the honey and Lyeopene refined, be prepared into pill according to the complete processing of pill.

Experimental example (embodiment 5 gained pill): in order to verify the effect of pill of the present invention, we have extracted 400 patients in 4 hospitals and have carried out the experiment of medicine, test group 200 people, control group 200 people, experimental group uses embodiment 5 gained pill, and control group uses medicine or the food of other treatment treatment mixed angina pectoris. Selected standard: through making a definite diagnosis as treatment mixed angina pectoris patient, have mixed angina pectoris clinical symptom one or more.

Using method: every time get pill of the present invention 1, sooner or later each 10 days is once a course for the treatment of, with good conditionsi can take always.

Curative effect situation criterion: 1, cure, it may also be useful to after this product, malaise symptoms completely dissolve; 2, effective, it may also be useful to after this product, malaise symptoms alleviates or part disappears; 3, invalid, it may also be useful to after this product, malaise symptoms is unchanged. Experimental data has been carried out accurate statistics and mathematical analysis by us. Specific experiment result is such as following table:

Table 1: two groups of Clinical efficacy comparison [example] tables 1

Treatment treatment mixed angina pectoris is had significant curative effect by pill of the present invention, mixed angina pectoris patient in various degree can be treated, there is efficiency up to 98%, curative ratio is up to 96%, severe patient is at use gained pill of the present invention after 20 days, and symptom also can alleviate, and the pill of this invention is cheap, evident in efficacy, the present invention is a kind for the treatment of mixed angina pectoris safety and pill without any side effects.

Claims (10)

1. treat the pill of mixed angina pectoris for one kind, it is characterised in that: the weight proportion of each bulk drug is as follows, is weight part:

Ginkgo Leaf 20-30 shizandra berry 5-15 kendir 5-15

Corn 6-16 glossy ganoderma 10-20 stem of noble dendrobium 15-25

Red sage root 1-5 Herba Centellae 8-20 Pigs Hearts 10-15

Lyeopene 2-6 soybean 10-30 strangles fish 20-40

Cassia twig 6-13.

2. the pill for the treatment of mixed angina pectoris according to claim 1, it is characterised in that: the weight proportion of each bulk drug is as follows, is weight part:

Ginkgo Leaf 23-28 shizandra berry 8-13 kendir 8-13

Corn 10-12 glossy ganoderma 13-18 stem of noble dendrobium 18-23

Red sage root 2-4 Herba Centellae 14-16 Pigs Hearts 11-14

Lyeopene 3-5 soybean 15-25 strangles fish 25-35

Cassia twig 8-10.

3. the pill for the treatment of mixed angina pectoris according to claim 1, it is characterised in that: the weight proportion of each bulk drug is as follows, is weight part:

Ginkgo Leaf 25 shizandra berry 11 kendir 10

Corn 11 glossy ganoderma 15 stem of noble dendrobium 20

The red sage root 3 Herba Centellae 15 Pigs Hearts 13

Lyeopene 4 soybean 20 Le fish 30

Cassia twig 9.

4. the preparation method of the pill for the treatment of mixed angina pectoris according to the arbitrary item of claim 1-3, it is characterised in that: step is as follows:

(1) Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, the stem of noble dendrobium, the red sage root, Herba Centellae are cleaned together with cassia twig, soak 20-40 hour with the light-coloured vinegar of Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, the stem of noble dendrobium, the red sage root, Herba Centellae and cassia twig weight 2-5 times, soaked bulk drug strainer is taken out, it is placed in the iron pot burning heat and repeatedly turns over stir-fry 12-24 minute, dry in the air cool, grind to form smalls, cross 80-120 order sieve stand-by;

(2) corn being ground peeling to be together placed in transparent Glass Containers with soybean, add the warm water of 40-50 DEG C, it is stand-by that sealing soaks 2-4 hour;

(3) Le fish is cleaned the block being cut into nail size, mix thoroughly with soy sauce, cooking wine, onion parts, ginger splices and Chinese prickly ash, with preservative film parcel, place 28-48 minute, take out and strangle fish, putting into edible oil in the hot pot dryouied, the consumption of edible oil is 10-20 times that strangles fish weight, edible oil is fired surrounding and plays cigarette, put into the Le fish pickled, fried 2-6 time repeatedly, dry in the air to crisp, grind to form smalls stand-by;

(4) being placed in marmite by clean for Pigs Hearts, add Pigs Hearts weight 3-7 light salt brine doubly, big fire is boiled, and puts into step (2) gained corn and soybean, and fire of larding speech with literary allusions is slow to be simmered 70-90 minute, filtration, and filtrate is stand-by, takes out Pigs Hearts, cuts into slices and dry on fire, grind broken stand-by;

(5) step (1), (3) and (4) gains are mixed even, decoct to boil and stir into thick cream and add the honey and Lyeopene refined, be prepared into pill according to the complete processing of pill.

5. the preparation method of pill according to claim 4, it is characterized in that: step (1) Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, the stem of noble dendrobium, the red sage root, Herba Centellae and cassia twig weight 3-4 light-coloured vinegar doubly soaks 25-35 hour (preferred, to soak 30 hours with the light-coloured vinegar of Ginkgo Leaf, shizandra berry, kendir, glossy ganoderma, the stem of noble dendrobium, the red sage root, Herba Centellae and cassia twig weight 3.5 times).

6. the preparation method of pill according to claim 4, it is characterised in that: step (1) be placed in the iron pot burning heat repeatedly turn over fry 16-20 minute (preferred, be placed in the iron pot burning heat repeatedly turn over fry 18 minutes).

7. the preparation method of pill according to claim 4, it is characterised in that: step (2) adds the warm water of 43-48 DEG C, and sealing is soaked 2.5-3.5 hour stand-by (preferred, add the warm water of 45 DEG C, it is stand-by that sealing soaks 3 hours).

8. the preparation method of pill according to claim 4, it is characterised in that: step (3) preservative film parcel, places 34-42 minute (preferred, to wrap up with preservative film, place 38 minutes).

9. the preparation method of pill according to claim 4, it is characterised in that: the consumption of step (3) edible oil be strangle fish weight 13-18 doubly (preferred, the consumption of edible oil is 15 times that strangle fish weight).

10. the preparation method of pill according to claim 4, it is characterised in that: step (4) adds Pigs Hearts weight 4-6 light salt brine (preferred, to add the light salt brine of Pigs Hearts weight 5 times) doubly.