CN105616689A

CN105616689A - Preparation for external application and application of preparation for external application to preparation of medicines for treating lumbar disc herniation

Info

Publication number: CN105616689A
Application number: CN201610079627.XA
Authority: CN
Inventors: 寿根其
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-05-08
Filing date: 2016-02-04
Publication date: 2016-06-01
Also published as: WO2016180119A1; CN104887755A

Abstract

The invention discloses a preparation for external application and application of the preparation for external application to preparation of medicines for treating lumbar disc herniation. The preparation for external application is prepared by adding components into per 1000g of fermentation liquor, wherein the components include 7-8ml of oleum ocimi gratissimi, 4-5ml of methyl salicylate, 1.10-0.15g of camphor oil, 0.2-0.3g of cinnamon oil, 0.2-0.3g of cinnamaldehyde, 0.005-0.01g of citral and 0.02-0.04g of borneol. The fermentation liquor is prepared by well mixing dry peppers with an acetic acid aqueous solution, fermenting for 7-9 days at the temperature of 15-20 DEG C, and filtering to obtain filtrate as the fermentation liquor, wherein the weight percentage of acetic acid in the acetic acid aqueous solution is 7%-9%, and 1.6-2.5g of the dry peppers are added into per 10g of the acetic acid aqueous solution. The preparation for external application is directly applied to affected parts with lumbar disc herniation and has the advantages of convenience and safety in use, short treatment course and favorable effects, thereby bringing hopes for patients suffering from lumbar disc herniation.

Description

A kind of external preparation and the application in preparation treatment prolapse of lumbar intervertebral disc medicine thereof

(1) technical field

The present invention relates to a kind of external medicine preparation, its preparation method and the application in preparation treatment prolapse of lumbar intervertebral disc medicine thereof.

(2) background technology

Prolapse of lumbar intervertebral disc is a kind of commonly encountered diseases, treats relatively difficult, and operative treatment risk is very big, and relapse rate is at 30%-50%, and improper meeting of performing the operation causes general paralysis, and the medicine for the treatment of prolapse of lumbar intervertebral disc is also more rare.

Chinese patent application CN02109766 describes a kind of oral Chinese medicine treating lumbar intervertebral disc protrusion, hyperosteogeny, adopts the Traditional Chinese medicine decoctings such as Lignum Sappan, Radix Salviae Miltiorrhizae, Radix Achyranthis Bidentatae to form. Chinese patent application CN03100479 describes one " Baikangtie " plaster, makes with Fel Ursi, Cordyceps, Stigma Croci, Pheretima, Shui Zhongjiao, Resina Draconis, Radix Angelicae Sinensis, Carapax et Plastrum Testudinis, Trionyx sinensis Wiegmann plate, Folium Isatidis, Radix Codonopsis, Radix Ginseng, Radix Notoginseng, Radix Ginseng Rubra, eupolyphage sece steleophaga, Elaphe moellendorffi, Scorpio, Caulis Spatholobi etc. But the effect of these medicines is all individual less prominent, seldom can substantially onset.

(3) summary of the invention

It is desirable to provide one is to the treatment effective external medicine preparation of prolapse of lumbar intervertebral disc and preparation method, another goal of the invention of the present invention relates to this pharmaceutical preparation application in preparation treatment prolapse of lumbar intervertebral disc medicine.

For realizing the purpose of the present invention, technical solution of the present invention is as follows:

A kind of external medicine preparation, described pharmaceutical preparation is to add following composition in every 1000g fermentation liquid (liquid A) to prepare:

Oleum Ocimi Gratissimi 7-8ml,

Methyl salicylate 4-5ml,

JIANGZHANGYOU 0.10-0.15g,

Oleum Cinnamomi 0.2-0.3g,

Cinnamic aldehyde 0.2-0.3g,

Citral 0.005-0.01g,

Borneolum Syntheticum 0.02-0.04g

Described fermentation liquid prepares as follows: crosses leaching filtrate in 15 DEG C-20 DEG C temperature conditions bottom fermentations after 7-9 days after the mixing of Fructus Capsici and aqueous acetic acid and obtains fermentation liquid, in described aqueous acetic acid, acetic acid weight content is 7%-9%, described Fructus Capsici is with chilli weighing scale addition for 1.5-2.5g/10g aqueous acetic acid, it is preferable that 2-2.3g/10g aqueous acetic acid.

Fructus Capsici described in external medicine preparation of the present invention is recommended as chilli pieces, more preferably dry chilli pieces. Dry chilli pieces of the present invention refers to the degree of drying that chilli is with the hands easily crumbed.

Further, the external medicine preparation that the present invention is preferably described, described pharmaceutical preparation is to add following composition in every 1000g fermentation liquid to prepare:

Oleum Ocimi Gratissimi 7.2-7.5ml,

Methyl salicylate 4-5ml,

JIANGZHANGYOU 0.12-0.15g,

Oleum Cinnamomi 0.25-0.28g,

Cinnamic aldehyde 0.25-0.28g,

Citral 0.006-0.01g,

Borneolum Syntheticum 0.02-0.04g

Described fermentation liquid prepares as follows: crosses leaching filtrate in 15 DEG C-20 DEG C temperature conditions bottom fermentations after 7-9 days after the mixing of Fructus Capsici and aqueous acetic acid and obtains fermentation liquid, in described aqueous acetic acid, acetic acid weight content is 7%-9%, and described Fructus Capsici is with chilli weighing scale addition for 2-2.3g/10g aqueous acetic acid.

Described fermentation liquid most preferably prepares as follows: crosses leaching filtrate in 18 DEG C-20 DEG C temperature conditions bottom fermentations after 7-8 days after the mixing of Fructus Capsici and aqueous acetic acid and obtains fermentation liquid, in described aqueous acetic acid, acetic acid weight content is 7%-9%, and described Fructus Capsici is with chilli weighing scale addition for 2-2.15g/10g aqueous acetic acid.

It addition, the preparation method that the present invention also provides for this external medicine preparation, described method carries out as follows:

(1) preparation of liquid A: obtain fermentation liquid and liquid A by crossing leaching filtrate in 15 DEG C-20 DEG C temperature conditions bottom fermentations after 7-9 days after the mixing of broken Fructus Capsici and aqueous acetic acid, in described aqueous acetic acid, acetic acid weight content is 7%-9%, and described Fructus Capsici is with chilli weighing scale addition for 2-2.3g/10g aqueous acetic acid.

(2) composition of following dosage is added by every 1000g fermentation liquid: Oleum Ocimi Gratissimi 7-8ml, methyl salicylate 4-5ml, JIANGZHANGYOU 0.10-0.15g, Oleum Cinnamomi 0.2-0.3g, cinnamic aldehyde 0.2-0.3g, citral 0.005-0.01g, Borneolum Syntheticum 0.02-0.04g; Stirring is fully all dissolved and obtains external medicine preparation.

This external medicine preparation is water preparation, the color and luster of medicinal liquid starts to finally generally becoming pink from rhodo along with preparation, and when medicinal liquid becomes pink, preparation is accused and made, and can use at any time, this external medicine preparation has a small amount of precipitation after placing a period of time, but does not affect result of use.

This external medicine preparation that the invention still further relates to application in preparation treatment prolapse of lumbar intervertebral disc medicine, the concrete external medicine preparation being prepared into is generally used for directly smearing the affected part in prolapse of lumbar intervertebral disc. Recommending smear every day 1-3 time, normally about within 7 days, just can eliminate pain, the course of disease is longer, within 1-3 month, also can cure, and treatment time is short, satisfactory for result.

The external medicine preparation that the present invention relates to is compared with prior art, the beneficial effects are mainly as follows: provide a kind of brand-new external medicine preparation agent that can be used for prolapse of lumbar intervertebral disc treatment, easy to use, short treating period, using safety, for prolapse of lumbar intervertebral disc, patient brings Gospel.

(4) detailed description of the invention

Below in conjunction with specific embodiment, the present invention is described further, but protection scope of the present invention is not limited to that:

The preparation method of the preparation of embodiment of the present invention treatment prolapse of lumbar intervertebral disc comprises the steps:

(1) preparation of liquid A: obtain fermentation liquid and liquid A by crossing leaching filtrate in 15 DEG C-20 DEG C temperature conditions bottom fermentations after 7-9 days after the mixing of broken Fructus Capsici and aqueous acetic acid, in described aqueous acetic acid, acetic acid weight content is 7%-9%, and described Fructus Capsici is with chilli weighing scale addition for 1.6-2.5g/10g aqueous acetic acid.

(2) composition of following dosage is added by every 1000g fermentation liquid (liquid A): Oleum Ocimi Gratissimi 7-8ml, methyl salicylate 4-5ml, JIANGZHANGYOU 0.10-0.15g, Oleum Cinnamomi 0.2-0.3g, cinnamic aldehyde 0.2-0.3g, citral 0.005-0.01g, Borneolum Syntheticum 0.02-0.04g; Stirring is fully all dissolved and obtains target formulation.

The color and luster of liquid becomes pink from rhodo, and namely this preparation is accused and made, and can use at any time. Preparation has a small amount of precipitation after placing a period of time, but does not affect result of use.

Embodiment 1

(1) preparation of composition A: (namely the content of acetic acid is the vinegar aqueous acid of 8% percentage by weight to put into the aqueous acetic acid 4150g of concentration 8% in vial, below all same), add dry crushing Fructus Capsici 850g, after making its Homogeneous phase mixing, making its natural fermentation, ambient temperature 20 DEG C, after fermentation in 7 days is complete, filter, obtain 4050g liquid A.

(2) formula of composition B: Oleum Ocimi Gratissimi 7.3ml, methyl salicylate 4.8ml, JIANGZHANGYOU 0.14g, Oleum Cinnamomi 0.277g, cinnamic aldehyde 0.277g, citral 0.009g, Borneolum Syntheticum 0.03g.

(3) formulated: take liquid A 1000g and put in beaker, is gradually added the various compositions in B formula, stirs while adding, until the various compositions in B formula all dissolve and obtain target formulation.

Embodiment 2

(1) preparation of composition A: put into the aqueous acetic acid 4100g of concentration 9% in vial, adds dry crushing Fructus Capsici 880g so that it is after Homogeneous phase mixing, natural fermentation, and ambient temperature is at 18 DEG C, and after fermentation in 8 days is complete, filters, obtains 4000g liquid A.

(2) formula of composition B: Oleum Ocimi Gratissimi 7.5ml, methyl salicylate 5ml, JIANGZHANGYOU 0.15g, Oleum Cinnamomi 0.28g, cinnamic aldehyde 0.28g, citral 0.01g, Borneolum Syntheticum 0.04g.

(3) formulated: take liquid A 1000g and put in beaker, is gradually added every kind of composition in B formula, stirs while adding, until the various compositions in B formula all dissolve and obtain target formulation.

Embodiment 3

(1) preparation of composition A: put into concentration 7% aqueous acetic acid 4200g in vial, adds dry crushing Fructus Capsici 850g so that it is Homogeneous phase mixing, makes its natural fermentation, and ambient temperature is at 20 DEG C, and after fermentation in 7 days is complete, filters, obtains 4100g liquid A.

(2) formula of composition B: Oleum Ocimi Gratissimi 7.2ml, methyl salicylate 4.5ml, JIANGZHANGYOU 0.12g, Oleum Cinnamomi 0.25g, cinnamic aldehyde 0.25g, citral 0.006g, Borneolum Syntheticum 0.02g.

Embodiment 4

(1) preparation of composition A: put into the aqueous acetic acid 4000g (namely the content of acetic acid is the vinegar aqueous acid of 8% percentage by weight) of concentration 8% in vial, add dry crushing Fructus Capsici 920g, after making its Homogeneous phase mixing, make its natural fermentation, ambient temperature 15 DEG C, after fermentation in 9 days is complete, filters, obtains 3900g liquid A.

(2) formula of composition B: Oleum Ocimi Gratissimi 31.2ml, methyl salicylate 15.6ml, JIANGZHANGYOU 0.39g, Oleum Cinnamomi 1.17g, cinnamic aldehyde 1.17g, citral 0.0195g, Borneolum Syntheticum 0.117g; (be equivalent to every 1000g liquid A 1 adds Oleum Ocimi Gratissimi 8ml, methyl salicylate 4ml, JIANGZHANGYOU 0.1g, Oleum Cinnamomi 0.3g, cinnamic aldehyde 0.3g, citral 0.005g, Borneolum Syntheticum 0.03g.

(3) formulated: take liquid A 3900g and put in beaker, is gradually added the various compositions in B formula, stirs while adding, until the various compositions in B formula all dissolve and obtain target formulation.

Embodiment 5

(1) preparation of composition A: put into the aqueous acetic acid 3800g (namely the content of acetic acid is the vinegar aqueous acid of 9% percentage by weight) of concentration 9% in vial, add dry crushing Fructus Capsici 950g, after making its Homogeneous phase mixing, make its natural fermentation, ambient temperature 15 DEG C, after fermentation in 8 days is complete, filters, obtains 3700g liquid A.

(2) formula of composition B: Oleum Ocimi Gratissimi 29.6ml, methyl salicylate 18.5ml, JIANGZHANGYOU 0.481g, Oleum Cinnamomi 0.74g, cinnamic aldehyde 0.74g, citral 0.0296g, Borneolum Syntheticum 0.074g; (be equivalent to every 1000g liquid A 1 adds Oleum Ocimi Gratissimi 8ml, methyl salicylate 5ml, JIANGZHANGYOU 0.13g, Oleum Cinnamomi 0.2g, cinnamic aldehyde 0.2g, citral 0.008g, Borneolum Syntheticum 0.02g.

(3) formulated: take liquid A 3700g and put in beaker, is gradually added the various compositions in B formula, stirs while adding, until the various compositions in B formula all dissolve and obtain target formulation.

Embodiment 6

(1) preparation of composition A: put into the aqueous acetic acid 4800g (namely the content of acetic acid is the vinegar aqueous acid of 7% percentage by weight) of concentration 7% in vial, add dry crushing Fructus Capsici 768g, after making its Homogeneous phase mixing, make its natural fermentation, ambient temperature 19 DEG C, after fermentation in 9 days is complete, filters, obtains 4700g liquid A.

(2) formula of composition B: Oleum Ocimi Gratissimi 32.9ml, methyl salicylate 18.8ml, JIANGZHANGYOU 0.47g, Oleum Cinnamomi 0.94g, cinnamic aldehyde 0.94g, citral 0.0235g, Borneolum Syntheticum 0.094g; (be equivalent to every 1000g liquid A 1 adds Oleum Ocimi Gratissimi 7ml, methyl salicylate 4ml, JIANGZHANGYOU 0.1g, Oleum Cinnamomi 0.2g, cinnamic aldehyde 0.2g, citral 0.005g, Borneolum Syntheticum 0.02g.

(3) formulated: take liquid A 4700g and put in beaker, is gradually added the various compositions in B formula, stirs while adding, until the various compositions in B formula all dissolve and obtain target formulation.

The formulation concentrations slightly difference that above-mentioned 6 embodiments prepare, but therapeutic effect is not clearly distinguished from. The feature of this preparation is: during with this preparation to the patient of prolapse of lumbar intervertebral disc, as long as coat some preparation at prolapse of lumbar intervertebral disc place, each consumption is less than 0.5 milliliter. Every day 1-3 time, within 7 days, just substantially eliminate pain, the Cortex Lycii being corroded backfit voluntarily, generally once a day. If disease time is more than 3 months, even existing 3-30 medical history, and the hard thing that existing phosphorus, calcium, magnesium etc. condense outside lumbar intervertebral disc bone, after this preparation is coated with 1-3 month, above-mentioned symptom also can disappear, further, after this liquid medicine has been coated with 7 days, it is possible to suitably reduce the number of times of painting depending on the alleviation degree of the state of an illness, such as every day 1-2 time, even may decrease to and be coated with every two days once. After symptom all disappears, repaste one, two weeks. Try out the patient of this liquid medicine, up to the present the longest after rehabilitation two months one year, it is showed no recurrence.

Raw material used by this preparation all can commercially, and aqueous acetic acid can mix in required ratio with glacial acetic acid and water.

The effect of each composition in this preparation:

Aqueous acetic acid, Fructus Capsici: Fructus Capsici accelerates the infiltration of acetic acid, improves the environment of perilesional.

Oleum Ocimi Gratissimi: topical pain relief, antiseptic.

Methyl salicylate: there is local irritant effect, can blood circulation promoting, play detumescence, antiinflammatory and analgesic activity.

Oleum Cinnamomi: dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow, wind dispelling, contribute to treatment rheumatism and skin pruritus.

Cinnamic aldehyde: there is the effect of sterilization, sterilization, anticorrosion, analgesia, scattered silt blood and blood circulation promoting

Citral: antibacterial, antisepsis.

Borneolum Syntheticum: kind dissipate gas, dissipate blood, dissipate fire, dissipate stagnant, sensible, by pathogen, can deep heat extraction, for pathogenic wind toxic to the marrow, toothache, hemorrhoid, conjunctival congestion and swelling pain, sore throat aphtha, routed after do not held back certain effect.

Therapeutic effect is illustrated:

1, turning round and look at ��, female, 53 years old, in August, 1985, doctor confirmed as prolapse of lumbar intervertebral disc and cervical spondylosis after checking because of the uncomfortable hospital that goes. Until in June, 2014, disease is all without curing completely, and both hands have also appeared the symptom of fiber crops. Starting to use the preparation of embodiment 1 morning on June 20th, 2014, in affected part, every day smears 2 times, and after 7 days, pain disappears substantially, and after 20 days, malaise symptoms is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present nearly 1 year, do not recur. Note: use reagent be first week 2 times/day, 1-2 times/day afterwards.

2, Xu's ��, man, 58 years old, in August, 2008 went to hospital's (Jiaxing armed police hospital) because of uncomfortable, confirms as prolapse of lumbar intervertebral disc and cervical spondylosis after inspection, but this disease is always all without treating completely. Until starting to use the preparation of example 1 afternoon on April 18th, 2014, in affected part, every day smears 3 times, and after 7 days, pain disappears substantially, and after 10 days, pain is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present one year, do not recur.

3, Xu's ��, female, 49 years old, suffer from prolapse of lumbar intervertebral disc February, smear affected part 1 time every day with the preparation of embodiment 1, after being coated with 7 days, symptom is wholly absent, and stops being coated with use after repasting 1 week. Up to the present existing 8 months, recurrence is had no.

4, Zhu's ��, female, 43 years old, suffer from prolapse of lumbar intervertebral disc 6 months, smear affected part 1 time every day with the preparation of embodiment 1, after being coated with 7 days, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present existing 7 months, recurrence is had no.

5, turning round and look at ��, female, 53 years old, suffer from prolapse of lumbar intervertebral disc 2 years, smear affected part 1 time every day with the preparation of embodiment 1, after being coated with 20 days, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present one year, recurrence is had no.

6, Xu's ��, female, 63 years old, suffer from prolapse of lumbar intervertebral disc 4 years, smear affected part 1 time every day with the preparation of embodiment 1, and after being coated with 20 days, symptom is wholly absent, and stops being coated with and use after repasting 2 weeks. Up to the present one year, recurrence is had no.

7, Jiang's ��, man, 58 years old, suffer from prolapse of lumbar intervertebral disc 5 years, smear affected part 1 time every day with the preparation of embodiment 1, after being coated with 20 days, symptom is wholly absent, and stops being coated with and use after repasting 2 weeks. Up to the present existing 7 months, recurrence is had no.

8, �� is tried to gain, female, 34 years old, suffer from prolapse of lumbar intervertebral disc 2 months, smear affected part 1 time with the preparation of embodiment 1, after being coated with 1 day, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present existing 8 months, recurrence is had no.

9, Xu's ��, man, 58 years old, suffer from prolapse of lumbar intervertebral disc 3 years, smear affected part 1 time every day with the preparation of embodiment 1, after being coated with 10 days, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present one year, recurrence is had no.

10, hear ��, man, 32 years old, suffer from prolapse of lumbar intervertebral disc 3 months, smear affected part 1 time every day with the preparation of embodiment 2, after being coated with 2 days, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present existing 8 months, recurrence is had no.

11, Wu's ��, female, 35 years old, suffer from prolapse of lumbar intervertebral disc 1 year, smear affected part 1 time every day with the preparation of embodiment 2, after being coated with 15 days, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present one year, recurrence is had no.

12, horse ��, man, 48 years old, suffer from prolapse of lumbar intervertebral disc 5 years, smear affected part 1 time every day with the preparation of embodiment 2, after being coated with 30 days, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present one year, recurrence is had no.

13, Cao's �� (man) 42 years old, suffers from prolapse of lumbar intervertebral disc 5 years, smears affected part 1 time every day with the preparation of embodiment 2, and after being coated with 10 days, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present one year, recurrence is had no.

14, Cao's ��, man, 51 years old, suffer from prolapse of lumbar intervertebral disc 3 years, smear affected part 1 time every day with the preparation of embodiment 2, after being coated with 7 days, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present one year, recurrence is had no.

15, slowly ��, female, 65, suffer from prolapse of lumbar intervertebral disc 5 years, smear affected part 1 time every day with the preparation of embodiment 2, after being coated with 20 days, symptom is wholly absent, and stops being coated with and use after repasting 10 days. Up to the present one year two months, recurrence is had no.

16, opening ��, man, 52 years old, (once driving cutter in hospital before 1 year six months) smeared affected part 3 times with the preparation of embodiment 2 every day to suffer from prolapse of lumbar intervertebral disc 8 years, and after being coated with 7 days, symptom is wholly absent, and stops being coated with and use after repasting 10 days. Up to the present one year, recurrence is had no.

17, �� is opened, female, 52 years old, suffer from prolapse of lumbar intervertebral disc 1 year six months, smear affected part 1 time every day with the preparation of embodiment 2, after being coated with 10 days, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present one year, recurrence is had no.

18, Miao's ��, man, 53 years old, suffer from prolapse of lumbar intervertebral disc 1 year, smear affected part 1 time every day with the preparation of embodiment 3, after being coated with 7 days, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present one year, recurrence is had no.

19, king's ��, man, 53 years old, suffer from prolapse of lumbar intervertebral disc 1 year, smear affected part 1 time every day with the preparation of embodiment 3, after being coated with 7 days, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present existing 7 months, recurrence is had no.

20, Shen �� (female) 56 years old, suffers from prolapse of lumbar intervertebral disc 1 year, smears affected part 1 time every day with the preparation of embodiment 3, and after being coated with 10 days, symptom is wholly absent, and stops being coated with and use after repasting 1 week. Up to the present existing 8 months, recurrence is had no.

21, king's ��, female, 45 years old, Nantong, in June, 2015 suffered from acute lumbar intervertebral disc protrusion and extremely aches, transference cure after being coated with 2 times with the preparation of embodiment 5 on the 3rd day. Up to the present do not recur.

22, king's ��, man, 65 years old, Nantong, in June, 2015 suffered from acute lumbar intervertebral disc protrusion and extremely aches, and foot also fiber crops ache simultaneously, smear affected part 2 times every day with the preparation of embodiment 5, up to the present do not recur after 3 days.

23, labor ��, female, 45 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc and once operated on existing 7 years for the treatment of in hospital, ache after recurrence hard to bear, she seeks medical advice everywhere does not have obvious effect. Use in May, 2015 embodiment 4 preparation to smear affected part 1 time every day, adhere to in JIUYUE, 2015 returning to one's perfect health, up to the present do not recur.

24, labor ��, female, 42 years old, Zhejiang Jiaxing, suffer from the existing 2-3 of prolapse of lumbar intervertebral disc, use in May, 2015 embodiment 4 preparation to smear affected part 1 time every day, after 1 month, physical recovery is healthy, recurrence that so far there are no.

25, opening ��, man, 45 years old, Zhejiang Jiaxing, suffered from prolapse of lumbar intervertebral disc and bone is deformed, used in August, 2014 embodiment 6 preparation to smear affected part 1 time every day, and after 4 months, health recovers completely, does not recur so far.

26, old ��, man, 55 years old, Zhejiang Jiaxing, suffer from the existing 5-6 of prolapse of lumbar intervertebral disc, use in April, 2015 embodiment 4 preparation to smear affected part 1 time every day, after one month, health recovers completely, does not recur so far.

27, �� is opened, man 62 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc existing 10 years, begin to use in April, 2015 embodiment 4 preparation to smear affected part 1 time every day, get well after 4 months and do not recur so far.

28, king's ��, man, 32 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc, in JIUYUE, 2015 uses embodiment 5 preparation to smear affected part 1 time every day, recovers, do not recur so far after 1 month.

29, envelope ��, man, 45 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc, within 2015 7, use embodiment 5 preparation to smear affected part 1 time every day, get well after 2 months, do not recur so far.

30, Yu's ��, female, 40 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc, use in July, 2015 embodiment 5 preparation to smear affected part 1 time every day, get well after 1 month, do not recur so far.

31 envelope ��s, female, 42 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc, use in July, 2015 embodiment 5 preparation to smear affected part 1 time every day, recover normal after 1 month completely, recurrence that so far there are no.

32, Miao's ��, female, 38 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc, in JIUYUE, 2014 uses embodiment 6 preparation to smear affected part 1 time every day, recovers normal after 5 months completely, recurrence that so far there are no.

33 king's ��s, man, 28 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc and once operated on treatment in hospital, recur after two-and-a-half years, use in October, 2014 embodiment 6 preparation to smear affected part 1 time every day, recover normal after 2 days completely, so far there are no recurs.

34, Hu ��, man 52 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc, use in June, 2015 embodiment 5 preparation to smear affected part 1 time every day, after 1 month, recover normal, recurrence that so far there are no.

35, Cao's ��, man 48 years old, Zhejiang Jiaxing, all ache very much before suffering from prolapse of lumbar intervertebral disc and sleeping and when driving, once at urgent disorder in orthopaedics hospital Jiaxing, Fuyang armed police hospital seeking medical attention, be apprised of and can not cure. Use in July, 2014 embodiment 6 preparation to smear affected part 1 time every day, after 3 months, recover normal, recurrence that so far there are no.

36, summer ��, female, 28 years old, Guizhou, suffer from prolapse of lumbar intervertebral disc and ache very much and affect normal operation, in JIUYUE, 2015 uses embodiment 5 preparation to smear affected part 1 time every day, recovers normal after 2 days completely, recurrence that so far there are no.

37, Lee's ��, female, 35 years old, Guizhou, suffer from prolapse of lumbar intervertebral disc, health is ached and is felt bad, and uses in August, 2015 embodiment 5 preparation to smear affected part 1 time every day, recovers normal after 2 days completely, recurrence that so far there are no.

38, Lee's ��, female, 34 years old, Guizhou, suffer from prolapse of lumbar intervertebral disc, health is extremely ached cisco unity malfunction, uses in August, 2015 embodiment 5 preparation to smear affected part 1 time every day, recovers normal after 1 day, recurrence that so far there are no.

39, king's ��, man, 52, year, Zhejiang Jiaxing, suffers from prolapse of lumbar intervertebral disc and once operated on treatment at Jiaxing armed police hospital, recur after two-and-a-half years, using in August, 2014 embodiment 6 to smear affected part 1 time every day, preparation recovers normal completely after 3 days, have so far and have no recurrence in 18 months.

40 Miao's ��s, female, 54 years old, Zhejiang Jiaxing, suffered from cervical spondylosis and both hands are numb, uses in March, 2015 embodiment 4 preparation to smear affected part 1 time every day, recovers completely after 1 month, recurrence that so far there are no.

41, Miao's ��, female, 52 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc, use in January, 2015 embodiment 4 preparation to smear affected part 1 time every day, return to one's perfect health after 15 days, recurrence that so far there are no.

42, Wu's ��, female, 65 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc when 35 years old always not good, use in March, 2015 embodiment 4 preparation to smear affected part 1 time every day, recover completely after 5 months, recurrence that so far there are no.

43, Yu's ��, female, 45 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc, use in June, 2015 embodiment 5 preparation to smear affected part 1 time every day, after 15 days, recover normal, recurrence that so far there are no.

44, Ni's ��, man, 48 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc, use in June, 2015 embodiment 5 preparation to smear affected part 1 time every day, after 30 days, recover normal, recurrence that so far there are no.

45, Wu's ��, female, 51 years old, Zhejiang Jiaxing, to suffer from prolapse of lumbar intervertebral disc, begin to use in August, 2014 embodiment 6 to smear affected part 1 time every day, preparation was got well after 5 months, recurrence that so far there are no.

46, Zhu's ��, man, 60 years old, Heze City, Shandong Province, suffer from prolapse of lumbar intervertebral disc existing 5 years, begin to use in April, 2015 embodiment 4 preparation to smear affected part 1 time every day, recover normal after 3 months completely, recurrence that so far there are no.

47, king's ��, man, 30 years old, Heze City, Shandong Province, suffer from existing 5 months of cervical spondylosis and both hands fiber crops, use embodiment 6 preparation to smear affected part 1 time every day, get well after 2 months, recurrence that so far there are no.

48, Yao's ��, man, 50 years old, Heze City, Shandong Province, suffer from prolapse of lumbar intervertebral disc existing 10 years, begin to use in April, 2015 embodiment 4 preparation to smear affected part 1 time every day, complete recovery of health after 1 month, recurrence that so far there are no.

49, Yao's ��, man, 80 years old, Heze City, Shandong Province, suffer from prolapse of lumbar intervertebral disc existing 50 years, use in April, 2015 embodiment 4 preparation to smear affected part 1 time every day, return to one's perfect health after 6 months, recurrence that so far there are no.

50, Cao's ��, female, 50 years old, Heze City, Shandong Province, suffer from prolapse of lumbar intervertebral disc existing 10 years, use in April, 2015 embodiment 4 preparation to smear affected part 1 time every day, complete recovery of health after 4 months, recurrence that so far there are no.

51, Yu's ��, female, 35 years old, Heze City, Shandong Province, suffer from prolapse of lumbar intervertebral disc existing 1 year, use in May, 2015 embodiment 4 preparation to smear affected part 1 time every day, complete recovery of health after 7 days, recurrence that so far there are no.

52, Lee's ��, man, 52 years old, Anhui, suffer from prolapse of lumbar intervertebral disc, use in June, 2015 embodiment 5 preparation to smear affected part 1 time every day, get well after 15 days, recurrence that so far there are no.

53, land ��, female, 42 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc, use in June, 2015 embodiment 5 preparation to smear affected part 1 time every day, get well after 2 months, recurrence that so far there are no.

54, �� is congratulated, female, 45 years old, Puyang oilfield of Henan, suffer from prolapse of lumbar intervertebral disc, use in July, 2015 embodiment 5 preparation to smear affected part 1 time every day, get well after 15 days, recurrence that so far there are no.

55, �� is congratulated, man, 67 years old, Puyang oilfield of Henan, suffer from prolapse of lumbar intervertebral disc, use in July, 2015 embodiment 5 preparation to smear affected part 1 time every day, get well after 1 month, recurrence that so far there are no.

56, woods ��, female, 80 years old, Ninghai, Zhejiang, suffers from prolapse of lumbar intervertebral disc for many years, through hospital diagnosis is: Section of three pressuring nerve of lumbar vertebra causes right crus of diaphragm uprightly freely to walk, embodiment 6 preparation is used in August, 2014 to smear affected part 1 time every day, can leave the bed after 1 month and walk about, complete recovery of health after being continuing with 15 days, recurrence that so far there are no.

57, Zhao's ��, man, 37 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc 5 years, after using in March, 2015 embodiment 4 preparation to smear affected part 1 time every day, within 2 months, return to one's perfect health, do not recur so far.

58, Zhao's ��, man, 40 years old, Zhejiang Jiaxing, suffer from prolapse of lumbar intervertebral disc and once operate on treatment in hospital, after 1 year, there is again recurrence in the state of an illness, uses in March, 2015 embodiment 4 preparation to smear affected part 1 time every day, returns to one's perfect health after 2 months, and so far there are no recurs.

59, Yu's ��, man, 32 years old, Linan, Zhejiang, suffer from prolapse of lumbar intervertebral disc, use in April, 2015 embodiment 4 preparation to smear affected part 1 time every day, within 2 months, return to one's perfect health, recurrence that so far there are no.

60, Shao's ��, man, 60 years old, Haining, suffer from prolapse of lumbar intervertebral disc 5 years, in JIUYUE, 2014 uses embodiment 6 preparation to smear affected part 1 time every day, within 2 months, returns to one's perfect health, recurrence that so far there are no.

61, not ��, female, 82 years old, Nantong, prolapse of lumbar intervertebral disc, in JIUYUE, 2014 used embodiment 6 preparation to smear affected part 1 time every day, within 1 month, returns to one's perfect health, recurrence that so far there are no.

Claims

1. an external medicine preparation, it is characterised in that described pharmaceutical preparation is to add following composition in every 1000g fermentation liquid to prepare:

Oleum Ocimi Gratissimi 7-8ml,

Methyl salicylate 4-5ml,

JIANGZHANGYOU 0.10-0.15g,

Oleum Cinnamomi 0.2-0.3g,

Cinnamic aldehyde 0.2-0.3g,

Citral 0.005-0.01g,

Borneolum Syntheticum 0.02-0.04g

Described fermentation liquid prepares as follows: crosses leaching filtrate in 15 DEG C-20 DEG C temperature conditions bottom fermentations after 7-9 days after the mixing of Fructus Capsici and aqueous acetic acid and obtains fermentation liquid, in described aqueous acetic acid, acetic acid weight content is 7%-9%, and described Fructus Capsici is with chilli weighing scale addition for 1.6-2.5g/10g aqueous acetic acid.

2. external medicine preparation as claimed in claim 1, it is characterised in that described Fructus Capsici is chilli pieces.

3. external medicine preparation as claimed in claim 1, it is characterised in that described Fructus Capsici is dry chilli pieces.

4. the external medicine preparation as described in one of claim 1-3, it is characterised in that described pharmaceutical preparation is to add following composition in every 1000g fermentation liquid to prepare:

Oleum Ocimi Gratissimi 7.2-7.5ml,

Methyl salicylate 4-5ml,

JIANGZHANGYOU 0.12-0.15g,

Oleum Cinnamomi 0.25-0.28g,

Cinnamic aldehyde 0.25-0.28g,

Citral 0.006-0.01g,

Borneolum Syntheticum 0.02-0.04g

Described fermentation liquid prepares as follows: crosses leaching filtrate in 18 DEG C-20 DEG C temperature conditions bottom fermentations after 7-9 days after the mixing of Fructus Capsici and aqueous acetic acid and obtains fermentation liquid, in described aqueous acetic acid, acetic acid weight content is 7%-9%, and described Fructus Capsici is with chilli weighing scale addition for 2-2.3g/10g aqueous acetic acid.

5. external medicine preparation as claimed in claim 4, it is characterized in that described fermentation liquid prepares as follows: cross leaching filtrate in 18 DEG C-20 DEG C temperature conditions bottom fermentations after 7-8 days after the mixing of Fructus Capsici and aqueous acetic acid and obtain fermentation liquid, in described aqueous acetic acid, acetic acid weight content is 7%-9%, and described Fructus Capsici is with chilli weighing scale addition for 2-2.15g/10g aqueous acetic acid.

6. the preparation method of external medicine preparation as claimed in claim 1, it is characterised in that described method carries out as follows:

7. the external medicine preparation as claimed in claim 1 application in preparation treatment prolapse of lumbar intervertebral disc medicine.

8. applying as claimed in claim 1, described external medicine preparation is for directly smearing the affected part in prolapse of lumbar intervertebral disc.