CN105596870A - 防治放疗后副作用的中药组合物 - Google Patents

防治放疗后副作用的中药组合物 Download PDF

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CN105596870A
CN105596870A CN201610114148.7A CN201610114148A CN105596870A CN 105596870 A CN105596870 A CN 105596870A CN 201610114148 A CN201610114148 A CN 201610114148A CN 105596870 A CN105596870 A CN 105596870A
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张银铃
王宗站
刁航航
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Qingdao Municipal Hospital
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Abstract

本发明属于中医中药技术领域，特别涉及一种防治放疗后副作用的中药组合物，由以下原料配制而成：老虎刺、土沙参、白背叶、补血草、黄精、角盘兰、独叶岩珠、复生草、枸杞子、菟丝子、仙茅、附子、龙骨、黄芪、姜竹茹、姜半夏、白芍、徐长卿。本发明通过中药的调理，益气、滋阴、补肾，适用于所有放疗后引起的全身反应，有助于放疗后病人体力的恢复，加快体内毒素排出，减轻肿块焮热症状，增加白细胞数量，加快身体恢复；同时具有提高免疫力的作用，更大程度的避免肿瘤复发，为病人的身体健康提供保障。

Description

防治放疗后副作用的中药组合物
技术领域
本发明属于中医中药技术领域，特别涉及一种防治放疗后副作用的中药组合物。
背景技术
肿瘤放射治疗是利用放射线如放射性同位素产生的α、β、γ射线和各类x射线治疗机或加速器产生的x射线、电子线、质子束及其它粒子束等治疗恶性肿瘤的一种方法。因癌细胞的生长和分裂比他们周围许多的正常细胞都要快，故采用特殊设备产生的高剂量射线照射癌变的肿瘤，可杀死或破坏癌细胞，抑制它们的生长、繁殖和扩散。虽然一些正常细胞也会受到破坏，但是大多数都会恢复。
放疗术后由于肿瘤组织崩解、毒素被吸收，在照射数小时或1～2天后，病人可出现全身反应，表现为虚弱、乏力、头晕、头痛、厌食，个别有恶心、呕吐等，特别是腹部照射和大面积照射时，反应较重。术后措施一般为进清淡饮食、蔬菜和水果，并鼓励多饮水，促进毒素排出。但癌症病人一般体虚，单靠食物和饮水恢复速度慢，残留毒素增加病人的身体负担，不利于病人的快速康复。中国专利（CN101108002）公开了一种用于放疗调补的中药，能够一定程度的减轻放疗副作用，但只适用于放疗期间减轻放疗后粘膜反应，具有一定的局限性。
发明内容
根据以上现有技术的不足，本发明提供一种防治放疗后副作用的中药组合物，其疗效显著、安全可靠、无毒副作用，具有广阔的临床应用前景。
本发明提供一种防治放疗后副作用的中药组合物，由以下重量份数的原料配制而成：老虎刺10~15份、土沙参10~15份、白背叶10~15份、补血草10~15份、黄精10~15份、角盘兰10~15份、独叶岩珠20~30份、复生草10~15份、枸杞子20~30份、菟丝子5~10份、仙茅5~10份、附子20~30份、龙骨10~15份、黄芪10~15份、姜竹茹10~15份、姜半夏10~15份、白芍5~10份、徐长卿5~10份。
进一步优选为由以下重量份数的原料配制而成：老虎刺12份、土沙参12份、白背叶12份、补血草12份、黄精12份、角盘兰12份、独叶岩珠25份、复生草12份、枸杞子25份、菟丝子8份、仙茅8份、附子25份、龙骨12份、黄芪12份、姜竹茹12份、姜半夏12份、白芍8份、徐长卿8份。
制备方法是按上述重量份称取中药原料，加入冷水，没过药材2～5cm，浸泡1～2个小时;然后进行煎煮，先用武火煮开，煮开后转为文火熬煮20～40min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
药理分析：
老虎刺：味甘；微苦；性温。健脾益气，补肾宁心，舒筋活络。主体虚乏力，食欲不振，腰膝酸软，阳痿；失眠多梦，健忘，风寒湿痹。
土沙参：味甘，性平。健脾益气；润肺止咳。主体虚自汗，乳汁不足，饮食少进，咳嗽，咯血。
白背叶：以根入药。微苦、涩，平。柔肝活血，健脾化湿，收敛固脱。用于慢性肝炎，肝脾肿大，子宫脱垂，脱肛，白带，妊娠水肿。
补血草：苦、咸，温。活血，止血，温中健脾，滋补强壮。用于月经不调，功能性子宫出血，痔疮出血，胃溃疡，脾虚浮肿。
黄精：甘，平，归脾、肺、肾经。润肺滋阴，补脾益气，丰肌泽肤、补肾益精。
角盘兰：甘，温。滋阴补肾，养胃，调经。用于神经衰弱，头晕失眠，烦躁口渴食欲不振，须发早白，月经不调。
独叶岩珠：味甘；淡；性寒。滋阴清热；解毒消肿。主阴虚内热；热病口渴；肺热咳喘；咽喉肿痛；口腔炎；风湿痹痛；跌打损伤；乳痈；疔肿。
复生草：淡，平。利尿，调经，滋阴补虚。主治水肿，头晕，耳鸣，小儿营养不良，月经不调，胃痛，小儿腹泻。
枸杞子：甘，平。归肝、肾经。滋补肝肾，益精明目。用于虚劳精亏，腰膝酸痛，眩晕耳鸣，内热消渴，血虚萎黄，目昏不明。
菟丝子：甘，温。归肝、肾、脾经。滋补肝肾，固精缩尿，安胎，明目，止泻。用于阳痿遗精，尿有余沥，遗尿尿频，腰膝酸软，目昏耳鸣，肾虚胎漏，胎动不安，脾肾虚泻；外治白癜风。
仙茅：辛，热；有毒。归肾、肝、脾经。补肾阳，强筋骨，祛寒湿。用于阳痿精冷，筋骨痿软，腰膝冷痹，阳虚冷泻。
附子：辛、甘，大热；有毒。归心、肾、脾经。回阳救逆，补火助阳，逐风寒湿邪。用于亡阳虚脱，肢冷脉微，阳萎，宫冷，心腹冷痛，虚寒吐泻，阴寒水肿，阳虚外感，寒湿痹痛。
龙骨：甘、涩，平。镇静，敛汗涩精，生肌敛疮。用于神经衰弱，心悸，失眠，多梦，自汗，盗汗，遗精，遗尿，崩漏，带下；外用治疮疡久溃不敛。
黄芪：甘，温。归肺、脾经。补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。
姜竹茹：甘，微寒。归肺、胃经。清热化痰，除烦止呕。用于痰热咳嗽，胆火挟痰，烦热呕吐，惊悸失眼，中风痰迷，舌强不语，胃热呕吐，妊娠恶阻，胎动不安。
姜半夏：辛、温；有毒。归脾、胃、肺经。降逆止呕。用于呕吐反胃，胸脘痞闷，梅核气。
白芍：苦、酸，微寒。归肝、脾经。平肝止痛，养血调经，敛阴止汗。用于头痛眩晕，胁痛，腹痛，四肢挛痛，血虚萎黄，月经不调，自汗，盗汗。
徐长卿：辛，温。归肝、胃经。祛风化湿，止痛止痒。用于风湿痹痛，胃痛胀满，牙痛，腰痛，跌扑损伤，荨麻疹、湿疹。
本发明药物组方中，老虎刺、土沙参、白背叶、补血草温中健脾，滋补强壮；黄精、角盘兰、独叶岩珠、复生草滋阴潜阳，软坚散结；枸杞子、菟丝子、仙茅补肝肾，益精血；附子、龙骨、黄芪大补元气，复脉固脱；姜竹茹、姜半夏缓解恶心呕吐，食欲不振；白芍、徐长卿缓解癌症疼痛。
本发明通过中药的调理，益气、滋阴、补肾，适用于所有放疗后引起的全身反应，有助于放疗后病人体力的恢复，加快体内毒素排出，减轻肿块焮热症状，增加白细胞数量，加快身体恢复；同时具有提高免疫力的作用，更大程度的避免肿瘤复发，为病人的身体健康提供保障。
疗效判断：
显效：临床症状（虚弱、乏力、头晕、头痛、厌食、恶心、呕吐等）基本或大部分消失。
有效：临床症状明显好转。
无效：诸症无改善。
治疗结果：治疗200名放疗术后患者，使用5天本发明的中药后，显效156例，占78%，有效42例，占21%，无效2例，占1%。
附几例病例作进一步说明：
病例1：宋某，女，63岁，因胃癌改良根治术后行放疗，放疗后病人极度虚弱，伴有头晕、头痛、厌食、呕吐症状，使用5天本发明的中药，临床症状消失，进食良好，恢复情况较好。
病例2：宫某,男，42岁，肝癌放疗后，出现乏力、恶心、呕吐，伴有心慌气短、低热、放射部位的肿块焮热感，使用5天本发明的中药，临床症状消失，进食良好，体虚情况亦有明显改善。
具体实施方式
实施例1：
一种防治放疗后副作用的中药组合物，由以下重量份数的原料配制而成：老虎刺10份、土沙参10份、白背叶10份、补血草10份、黄精10份、角盘兰10份、独叶岩珠20份、复生草10份、枸杞子20份、菟丝子5份、仙茅5份、附子20份、龙骨10份、黄芪10份、姜竹茹10份、姜半夏10份、白芍5份、徐长卿5份。
制备方法是按上述重量份称取中药原料，加入冷水，没过药材4cm，浸泡1.5个小时;然后进行煎煮，先用武火煮开，煮开后转为文火熬煮30min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
实施例2：
一种防治放疗后副作用的中药组合物，由以下重量份数的原料配制而成：老虎刺15份、土沙参15份、白背叶15份、补血草15份、黄精15份、角盘兰15份、独叶岩珠30份、复生草15份、枸杞子30份、菟丝子10份、仙茅10份、附子30份、龙骨15份、黄芪15份、姜竹茹15份、姜半夏15份、白芍10份、徐长卿10份。
制备方法是按上述重量份称取中药原料，加入冷水，没过药材2cm，浸泡1个小时;然后进行煎煮，先用武火煮开，煮开后转为文火熬煮20min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
实施例3：
一种防治放疗后副作用的中药组合物，由以下重量份数的原料配制而成：老虎刺12份、土沙参12份、白背叶12份、补血草12份、黄精12份、角盘兰12份、独叶岩珠25份、复生草12份、枸杞子25份、菟丝子8份、仙茅8份、附子25份、龙骨12份、黄芪12份、姜竹茹12份、姜半夏12份、白芍8份、徐长卿8份。
制备方法是按上述重量份称取中药原料，加入冷水，没过药材5cm，浸泡2个小时;然后进行煎煮，先用武火煮开，煮开后转为文火熬煮40min；煮好后，滤出药汁作为头煎；将药渣重复上述步骤煎煮，煮好后，将两次煎煮的药汁合并即可。
以上已将本发明做一详细说明，以上所述，仅为本发明之较佳实施例而已，当不能限定本发明实施范围，即凡依本申请范围所作均等变化与修饰，皆应仍属本发明涵盖范围内。

Claims (2)

1.一种防治放疗后副作用的中药组合物，其特征在于由以下重量份数的原料配制而成：老虎刺10~15份、土沙参10~15份、白背叶10~15份、补血草10~15份、黄精10~15份、角盘兰10~15份、独叶岩珠20~30份、复生草10~15份、枸杞子20~30份、菟丝子5~10份、仙茅5~10份、附子20~30份、龙骨10~15份、黄芪10~15份、姜竹茹10~15份、姜半夏10~15份、白芍5~10份、徐长卿5~10份。
2.如权利要求1所述的防治放疗后副作用的中药组合物，其特征在于由以下重量份数的原料配制而成：老虎刺12份、土沙参12份、白背叶12份、补血草12份、黄精12份、角盘兰12份、独叶岩珠25份、复生草12份、枸杞子25份、菟丝子8份、仙茅8份、附子25份、龙骨12份、黄芪12份、姜竹茹12份、姜半夏12份、白芍8份、徐长卿8份。
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