CN105596763A - Traditional Chinese medicine composition for preventing and treating radiation-induced pulmonary injury - Google Patents

Traditional Chinese medicine composition for preventing and treating radiation-induced pulmonary injury Download PDF

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CN105596763A
CN105596763A CN201610084870.0A CN201610084870A CN105596763A CN 105596763 A CN105596763 A CN 105596763A CN 201610084870 A CN201610084870 A CN 201610084870A CN 105596763 A CN105596763 A CN 105596763A
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chinese medicine
medicine composition
induced pulmonary
radiation
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刘松军
魏淑英
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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating radiation-induced pulmonary injury. The traditional Chinese medicine composition is prepared from rhizome of conic gymnadenia, gynostemma pentaphylla, merremia hungaiensis, cymbidium ensifolium (L.)Sw., oxhide gelatin, flowers of herbs of common stonecrop, fig, greenish lily flowers, scabiosa tschiliensis Grun-ning and Chinese fevervine herbs. The traditional Chinese medicine composition for preventing and treating radiation-induced pulmonary injury has the advantages of being obvious in effect on prevention and treatment of radiation-induced pulmonary injury, free of side effect, good in patient compliance and the like. Water decoction of the traditional Chinese medicine composition for preventing and treating radiation-induced pulmonary injury is adopted to prevent and treat radiation-induced pulmonary injury for 43 patients, the curative effect is compared with that of a comparison group, as a result, the occurrence rates of the radiation-induced pulmonary injury in the early period and the later period of the comparison group are 26.19% and 57.14% respectively, while the occurrence rates of the treatment group are 9.30% and 25.58% respectively, the occurrence rates of the radiation-induced pulmonary injury in the early period and the later period of the treatment group are obviously lower than those of the comparison group, and the difference has statistical significance (P is smaller than 0.05).

Description

A kind of Chinese medicine composition of preventing and treating induced lung injury
Technical field
The present invention relates to Chinese medicine sciemtifec and technical sphere, particularly a kind of induced lung injury of preventing and treatingChinese medicine composition.
Background technology
Induced lung injury is the radiocurable common complication of breast tumor, to a certain degreeOn limited the exposure dosage of radiotherapy tumour, affected the completion rate of radiotherapy, reducePatient's quality of life. Current clinical employing Western medicine anti-inflammatory drug result for the treatment of is undesirable,And bad reaction is heavier. Therefore, researching and developing control evident in efficacy, side effect is little putsThe Chinese medicine preparation of penetrating property injury of lungs, will contribute to alleviate radiation insult, raising breast tumorRadiotherapy dosimetry. But Chinese medicine preparation also has the defect of self, because natural drug is mostly without carryingPure, the restriction of Chinese medicine method of administration in addition, anxious in treatment today of chemicals extensive useThe non-Chinese medicine chief of property induced lung injury. Therefore, be necessary " to preventive treatment of disease " according to the traditional Chinese medical sciencePrinciple, development just starts the Chinese medicine composition of the control induced lung injury of application before chemotherapy.
Summary of the invention
The deficiency that the object of the invention is to overcome prior art puts forward, and provides onePlant control induced lung injury Chinese medicine composition.
In order to realize foregoing invention object, the invention provides following technical scheme:
Prevent and treat a Chinese medicine composition for induced lung injury, by the raw material of following mass ratioMedicine is made:
9～15 parts of conic gymnadenia tubers, 10～20 parts of gynostemma pentaphylla, 40～60 parts of Ipomoea hungaiensis Lingelsh. Et Borzas, ox horn4～6 parts of pseudo-ginseng, 6～12 parts of oxhide gelatin, red-spotted stonecrop chi spend 9～15 parts, fig 20～40 parts, 6～12 parts of lilies, 1～3 part of Flos Scabiosae comosae, 30～50 parts of fevervines.
Conic gymnadenia tuber: sweet, flat. Benefiting qi and nourishing blood, Yishen Jianpi, promoting blood circulation and stopping pain. Cure mainly the deficiency syndrome of the lungCough, consumptive disease is become thin, neurasthenia, lassitude in loin and legs, impotence, involuntary emission, frequent micturition, chronicHepatitis, rushes down for a long time, loses blood, and under band, breast is few, traumatic injury.
Gynostemma pentaphylla: sweet, bitter, cold, return spleen, lung channel. Replenish qi to invigorate the spleen, preventing phlegm from forming and stopping coughing, clearThermal detoxification. Cure mainly syndrome of spleen deficiency, cough due to deficiency of the lung's card.
Ipomoea hungaiensis Lingelsh. Et Borza: sweet, bitter, flat. Nourishing generate fluid, liyan jiedu. Cure mainly giddy weak,Insomnia, the prolapse of uterus, prolapse of the anus, few breast, hot summer weather polydipsia, acute toothache, abscess of throat, scrofula,Sore furuncle, venomous snake bite.
Ox horn pseudo-ginseng: pungent, sweet, light, flat. Enriching yin clearing lung-heat, preventing phlegm from forming and stopping coughing. Cure mainly one hundred daysCough hemoptysis of pulmonary tuberculosis, neurasthenia, dizziness, pain in the back, urinary tract infections, leukorrhea.
Oxhide gelatin: sweet, flat, return lung, large intestine channel. Nourshing Yin and drynsessmoistening prescription, nourishing blood and hemoslasis, invigorates blood circulationDetumescence, removing toxic substances. Cure mainly consumptive disease consumptive lung disease, cough spitting of blood, tells nosebleed, uterine bleeding, and diarrhea is had blood in stool,Traumatic injury, skin sore, burn and scald.
Red-spotted stonecrop chi flower: sweet, be slightly cold, return lung channel. Clearing heat and moistening lung, removing toxicity for detumescence. Cure mainly lungHeat cough, tuberculosis, scrofula, mumps.
Fig: clearing heat and promoting fluid, spleen benefiting and stimulating the appetite, removing toxicity for detumescence. Cure mainly abscess of throat, dryCough trachyphonia, milk rareness, the hot constipation of intestines, poor appetite, indigestion, has loose bowels, dysentery,Carbuncle is swollen, tinea disease.
Lily: sweet, micro-hardship, be slightly cold, return liver, lung, the heart channel of Hang-Shaoyin. Clearing heat and moistening lung, Ning XinCalm the nerves. Cure mainly the few phlegm of cough or sticky, dizzy, vexed, uneasy sleeping at night, the wet sore of day blister.
Flos Scabiosae comosae: sweet, micro-hardship, cool. Clearing heat-fire. Cure mainly irascibility headache, fever,Cough with lung heat, jaundice.
Fevervine: sweet, bitter, be slightly cold, return spleen, stomach, liver, lung channel. Food digesting stomach fortifying, changesPhlegm and relieving cough, clearing heat and detoxicating, pain relieving. Cure mainly eating accumulation, infantile malnutrition; Phlegm heat cough;Hot poison rushes down dysentery, abscess of throat, carbuncle sore furuncle, burn and scald etc.; Gastrointestinal distress, cholecystalgia,Renal colic, dysmenorrhoea, labor pains, aches after neuralgia and various wound, fracture, operationPain etc.
Induced lung injury belongs to the traditional Chinese medical science " consumptive lung disease ", " cough ", " dyspnea ", " lung carbuncle " category.The traditional Chinese medical science thinks that radioactive ray belong to the heresy of heat poison, and the progress of disease is rapid, does not follow the biography of " defensive-qi-nutrient-blood "Become rule, easily consume impairment of yin blood. The traditional Chinese medical science thinks, " healthy tendency deposit in, heresy can not be done " is emphasized" healthy tendency " importance in disease prevention and cure. The principle of " preventiveing treatment of disease " according to the traditional Chinese medical science, YingAdjust before radiotherapy and mend human body " healthy tendency ", when striving for radiotherapy " heresy can not be done ", reduce radioactive rayTo the damage of lung. The traditional Chinese medical science is thought lung being a delicate viscus, happiness profit and dislike dry, should boosting qi and nourishing yin therefore control,The moistening lung of nourishing blood, clearing heat and eliminating phlegm. The present invention adopts conic gymnadenia tuber, gynostemma pentaphylla, Ipomoea hungaiensis Lingelsh. Et Borza, ox hornPseudo-ginseng tonifying lung gas, supports lung yin; Oxhide gelatin is moisturized and is nourished blood; Red-spotted stonecrop chi flower, fig, lilyFlower clearing heat and moistening lung; Flos Scabiosae comosae clearing heat-fire; Fevervine food digesting stomach fortifying, preventing phlegm from forming and stopping coughing.All medicines share, and lung qi hyperemia is prosperous, therefore " heresy can not be done ".
Preferably, the Chinese medicine composition of described control induced lung injury is by following mass ratioBulk drug make:
11～13 parts of conic gymnadenia tubers, 13～17 parts of gynostemma pentaphylla, 45～55 parts of Ipomoea hungaiensis Lingelsh. Et Borzas, ox4～6 parts of angle pseudo-ginseng, 8～10 parts of oxhide gelatin, red-spotted stonecrop chi spend 11～13 parts, fig 25～35 parts, 8～10 parts of lilies, 1～3 part of Flos Scabiosae comosae, 35～45 parts of fevervines.
Further preferred, the Chinese medicine composition of described control induced lung injury is by following matterThe bulk drug of amount ratio is made:
12 parts of conic gymnadenia tubers, 15 parts of gynostemma pentaphylla, 50 parts of Ipomoea hungaiensis Lingelsh. Et Borzas, 5 parts of ox horn pseudo-ginseng,9 parts of oxhide gelatin, red-spotted stonecrop chi are spent 12 parts, 30 parts of figs, 9 parts of lilies, Mongolian mountain2 parts of radish, 40 parts of fevervines.
The Chinese medicine composition of described control induced lung injury can adopt existing Chinese medicine preparationTechnology is prepared into any conventional oral preparations, for example, can adopt decocting to obtain said componentsWater decoction, can also damage described control lung radiation injury by other existing Chinese medicine preparation technologyThe Chinese medicine composition of wound is prepared into tablet, water-honeyed pill, capsule, powder, paste, oralLiquid, granule.
Compared with prior art, beneficial effect of the present invention
The Chinese medicine composition control lung radiation injury of control induced lung injury provided by the invention damagesThe advantages such as wound has successful, has no side effect, patient compliance is good.
Prevent and treat a Chinese medicine composition for induced lung injury, clinical efficacy is summed up
1 physical data
85 routine patients (lung cancer, the cancer of the esophagus, thymic carcinoma) all pass through cytology or pathology are trueExamine. Be divided at random 2 groups, control group 42 examples, the wherein male sex's 30 examples, women's 12 examples,Year mean age (58.75 ± 7.35); Treatment group 43 examples, the wherein male sex's 31 examples, women 12Example, year mean age (57.54 ± 6.34). 2 groups of ages, sex, histological type, tumourHappening part, KPS scoring, Radiotherapy dosimetry comparison, difference not statistically significant, having canThan property (P > 0.05).
2 diagnosis and grade scales
Induced lung injury diagnostic criteria is with reference to " Radiation Oncology " Plays; RadiationProperty injury of lungs grade scale is according to nineteen ninety-five U.S.'s radiation oncology cooperative groups (RTOG) classificationStandard (Yin Weibai, paddy milling it. Radiation Oncology. the 3rd edition. Beijing: China associationWith publishing house of medical university, 2002:1108.).
3 methods of treatments
2 groups of patients all carry out conventional radiotheraphy, and first 2 weeks for the treatment of group radiotherapy and radiation period are oralThe Chinese traditional medicine composition water decoction of control induced lung injury provided by the invention, composed as follows:
12 grams of conic gymnadenia tubers, 15 grams of gynostemma pentaphylla, 50 grams of Ipomoea hungaiensis Lingelsh. Et Borzas, 5 grams of ox horn pseudo-ginseng,9 grams of oxhide gelatin, red-spotted stonecrop chi are spent 12 grams, 30 grams of figs, 9 grams of lilies, Mongolian mountain40 grams of 2 grams of radish (grind into powder and take after mixing it with water), fevervine are made water according to conventional Chinese medicine preparation technologyDecoction, everyone potion every day.
4 treatment results
The incidence of control group induced lung injury in early stage and late period is respectively 26.19%,57.14%; Treatment group is respectively 9.30%, 25.58%, treatment group is early stage, late period radioactivityInjury of lungs incidence is all starkly lower than control group, and difference has statistical significance (P < 0.05).
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in further detail. But should notThis is interpreted as to the scope of the above-mentioned theme of the present invention only limits to following embodiment, all based on thisThe technology that summary of the invention is realized all belongs to scope of the present invention.
Embodiment 1
Preventing and treating a Chinese medicine composition for induced lung injury, is by 15 grams of conic gymnadenia tubers, strandBlue 20 grams of thigh, 60 grams of Ipomoea hungaiensis Lingelsh. Et Borzas, 6 grams of ox horn pseudo-ginseng, 12 grams of oxhide gelatin, red-spotted stonecrop chiSpend 15 grams, 40 grams of figs, 12 grams of lilies, Flos Scabiosae comosae (grind into powder and take after mixing it with water) 3Gram, 50 grams of fevervines make water decoction according to conventional Chinese medicine preparation technology, everyone every day oneAgent.
Embodiment 2
Preventing and treating a Chinese medicine composition for induced lung injury, is by 13 grams of conic gymnadenia tubers, strandBlue 17 grams of thigh, 55 grams of Ipomoea hungaiensis Lingelsh. Et Borzas, 6 grams of ox horn pseudo-ginseng, 10 grams of oxhide gelatin, red-spotted stonecrop chiSpend 13 grams, 35 grams of figs, 10 grams of lilies, Flos Scabiosae comosae (grind into powder and take after mixing it with water) 3Gram, 45 grams of fevervines make water decoction according to conventional Chinese medicine preparation technology, everyone every day oneAgent.
Embodiment 3
Preventing and treating a Chinese medicine composition for induced lung injury, is by 12 grams of conic gymnadenia tubers, strandBlue 15 grams of thigh, 50 grams of Ipomoea hungaiensis Lingelsh. Et Borzas, 5 grams of ox horn pseudo-ginseng, 9 grams of oxhide gelatin, red-spotted stonecrop chi flower12 grams, 30 grams of figs, 9 grams of lilies, 2 grams of Flos Scabiosae comosaes (grind into powder and take after mixing it with water),40 grams of fevervines are made water decoction according to conventional Chinese medicine preparation technology, everyone potion every day.
Embodiment 4
Preventing and treating a Chinese medicine composition for induced lung injury, is by 11 grams of conic gymnadenia tubers, strandBlue 13 grams of thigh, 45 grams of Ipomoea hungaiensis Lingelsh. Et Borzas, 4 grams of ox horn pseudo-ginseng, 8 grams of oxhide gelatin, red-spotted stonecrop chi flower11 grams, 25 grams of figs, 8 grams of lilies, 1 gram of Flos Scabiosae comosae (grind into powder and take after mixing it with water),35 grams of fevervines are made water decoction according to conventional Chinese medicine preparation technology, everyone potion every day.
Embodiment 5
Preventing and treating a Chinese medicine composition for induced lung injury, is by 9 grams of conic gymnadenia tubers, strand10 grams, indigo plant, 40 grams of Ipomoea hungaiensis Lingelsh. Et Borzas, 4 grams of ox horn pseudo-ginseng, 6 grams of oxhide gelatin, red-spotted stonecrop chi spend 9Gram, 20 grams of figs, 6 grams of lilies, 1 gram of Flos Scabiosae comosae (grind into powder and take after mixing it with water), chickenVow that 30 grams, rattan makes water decoction according to conventional Chinese medicine preparation technology, everyone potion every day.

Claims (4)

1. prevent and treat a Chinese medicine composition for induced lung injury, it is characterized in that by belowThe bulk drug of mass ratio is made:
9～15 parts of conic gymnadenia tubers, 10～20 parts of gynostemma pentaphylla, 40～60 parts of Ipomoea hungaiensis Lingelsh. Et Borzas, ox horn pseudo-ginseng4～6 parts, 6～12 parts of oxhide gelatin, red-spotted stonecrop chi spend 9～15 parts, 20～40 parts of figs,6～12 parts of lilies, 1～3 part of Flos Scabiosae comosae, 30～50 parts of fevervines.
2. the Chinese medicine composition of control induced lung injury as claimed in claim 1, itsBe characterised in that by the bulk drug of following mass ratio and make:
11～13 parts of conic gymnadenia tubers, 13～17 parts of gynostemma pentaphylla, 45～55 parts of Ipomoea hungaiensis Lingelsh. Et Borzas, ox horn three7 4～6 parts, 8～10 parts of oxhide gelatin, red-spotted stonecrop chi are spent 11～13 parts, fig 25～35Part, 8～10 parts of lilies, 1～3 part of Flos Scabiosae comosae, 35～45 parts of fevervines.
3. the Chinese medicine composition of control induced lung injury as claimed in claim 1, itsBe characterised in that by the bulk drug of following mass ratio and make:
12 parts of conic gymnadenia tubers, 15 parts of gynostemma pentaphylla, 50 parts of Ipomoea hungaiensis Lingelsh. Et Borzas, 5 parts of ox horn pseudo-ginseng,9 parts of oxhide gelatin, red-spotted stonecrop chi are spent 12 parts, 30 parts of figs, 9 parts of lilies, Mongolian mountain2 parts of radish, 40 parts of fevervines.
4. prevent and treat as claimed in claim 1 the preparation of the Chinese medicine composition of induced lung injuryMethod, it is characterized in that by the traditional Chinese medicinal components of described mass ratio be prepared into water decoction, tablet,Water-honeyed pill, capsule, powder, paste, oral liquid, granule.
CN201610084870.0A 2016-02-03 2016-02-03 Traditional Chinese medicine composition for preventing and treating radiation-induced pulmonary injury Pending CN105596763A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106177251A (en) * 2016-08-30 2016-12-07 郭英华 A kind of prevent and treat Chinese medicine preparation of injury of lung and preparation method thereof after tumor radiotherapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104758523A (en) * 2015-04-10 2015-07-08 邓进巍 Traditional Chinese medicinal composition for treating radiation pneumonitis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104758523A (en) * 2015-04-10 2015-07-08 邓进巍 Traditional Chinese medicinal composition for treating radiation pneumonitis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106177251A (en) * 2016-08-30 2016-12-07 郭英华 A kind of prevent and treat Chinese medicine preparation of injury of lung and preparation method thereof after tumor radiotherapy

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