CN105596754A - Traditional Chinese medicine for treating blood deficiency type postpartum pain of body and preparing method thereof - Google Patents

Traditional Chinese medicine for treating blood deficiency type postpartum pain of body and preparing method thereof Download PDF

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CN105596754A
CN105596754A CN201610057663.6A CN201610057663A CN105596754A CN 105596754 A CN105596754 A CN 105596754A CN 201610057663 A CN201610057663 A CN 201610057663A CN 105596754 A CN105596754 A CN 105596754A
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parts
root
chinese medicine
blood
fruit
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张敏
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Jinan Situo Xinyuan Pharmaceutical Technology Co Ltd
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Jinan Situo Xinyuan Pharmaceutical Technology Co Ltd
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Abstract

The invention discloses a traditional Chinese medicine for treating blood deficiency type postpartum pain of body and a preparing method thereof. The traditional Chinese medicine is prepared from radix astragali, root of false-yellowflower milkwort, lychee, root of broadleaf sedge, fruit of densehead mountainash, sieve bean, common embelia fruit, rhizoma chuanxiong, radix paeoniae alba, herba cistanche, radix angelica sinensis, Yunnan craibiodendron leaf, prepared rehmannia root, cutworm, dried scallop, all-grass of balanophora polyandra, herb of tall rattlesnake plantain, ventilago leiocarpa benth, caulis spatholobi, Junesnow, stem of falsenettleleaf pepper, pittosporum root, root of delavay violet, sinomenium acutum, ramulus cinnamomi, cinnamomum mairei bark, ulmus parvifolia stem, poria cocos, ludisia discolor, glossy ganoderma and radix acanthopanacis semticosi. The traditional Chinese medicine has the advantages that syndrome differentiation treatment is conducted based on the holistic view of an organism, the purely natural medicinal materials are selected and act on the focus directly, the treatment course is short, the treatment effect is good, the toxic or side effect is small, no adverse reaction is caused, health care of the organism is achieved to a certain degree while treatment is conducted, cost is low, the preparing process is simple, and the traditional Chinese medicine can be clinically popularized so as to meet the requirement for treatment of clinical postnatal diseases.

Description

A kind of Chinese medicine and preparation method who treats blood-deficiency type postpartum pain of body
Technical field
The present invention relates to pharmaceutical technology, particularly a kind of Chinese medicine and preparation side for the treatment of blood-deficiency type postpartum pain of bodyMethod.
Background technology
In puerperium, there is limbs, joint pain, numbness, heavy author, be called " postpartum pain of body ", also claim " pain all over "," arthralgia in postpartum ". The generation of this disease is mainly due to deficiency of qi and blood in postpartum, and passages through which vital energy circulates loses supports or plain body deficiency of the kidney, and vessels of the uterus loses supports, withAnd postpartum battalion defends imbalance, interspaces of skin and muscles being loose, the damp evil that is affected by the cold, makes due to QI-blood circulation is obstructed. Postpartum pain of body mainly divides following severalKind:
1. blood-deficiency type: excessive blood loss when product, or postpartum deficiency of vital energy and blood, muscle arteries and veins joint is lost in moistening foster, so that extremity numbness, limbs closeJoint is ached. Cardinal symptom is arthralgia all over, and limbs are miserable, numb, dizzy palpitaition, and arteries and veins is thin and delicate.
2. renal deficiency type: plain body deficiency of the kidney, all empty because of maternal infuries essence and blood, vessels of the uterus loses supports, so that ache of the spinal column, and leg knee is weak. MainlySymptom is pain in back and loin in postpartum, and waist leg is weak, talagia, and eyes are dim black, dizziness and tinnitus, tongue nature is light dim, deep thready pulse.
3. blood stasis type: lochia is not smooth, the hemostasis channels and collaterals of being detained, QI-blood circulation is obstructed and causes. Cardinal symptom is body in postpartumBitterly, outstanding lower limb pain, numbness, swelling is obvious, hardens, joint joint stuffiness, tongue is dark red, thready and hesitant pulse.
4. the evil type of sense: postpartum deficient qi and blood, disharmony between ying and wei, interspaces of skin and muscles being loose, if because of daily life careless, chill wet three evil taking advantage of a weak point in opponent's defence andEnter, keep channels and collaterals, joint, QI-blood circulation is obstructed, the stasis of blood is stagnant and have a pain. Cardinal symptom is the damp evil that is accidentally affected by the cold, and close on the whole bodyJoint pain, joint stuffiness, or migratory pain or sharp ache, or limb swelling, numbness is weighing, walks with difficulty, thready and moderate pulse.
Western medical treatment postpartum pain of body, therapeutic scheme limitation, conventional analgesic as: aspirin, brufen, indocin,Paracetamol, phenylbutazone, rofecoxib etc., treatment is longer the course for the treatment of, does not reach desirable clinical therapeutic efficacy. Prolonged application this type ofMedicine can cause more bad reaction and toxic and side effect. Chinese traditional treatment postpartum pain of body treatment prognosis is better, sees at animal economyOn basis, be particular about diagnosis and treatment, selected fully natural green medicinal material, the drug effect focus of go directly, treats the course for the treatment of shorter, and curative effect is better, poisonSide effect is less, has no adverse reaction, and in treatment, this can also play certain health-care effect, cost price to body in sickCheap, manufacture craft is simple, can carry out clinical expansion and meet the Treatment need of clinical postpartum pain of body.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine that cures mainly blood-deficiency type postpartum pain of body. The present invention hasTreatment blood-deficiency type postpartum pain of body treatment prognosis is better, on the basis of seeing, is particular about diagnosis and treatment at animal economy, and selected pure natural is greenLook medicinal material, the drug effect focus of going directly, treatment is shorter the course for the treatment of, and curative effect is better, and toxic and side effect is less, has no adverse reaction, in this disease for the treatment ofTime also post-natal depression is had to good curative effect, can play certain health-care effect to body, cost price is cheap, systemMake technique simple, can carry out clinical expansion and meet the feature of the Treatment need of clinical postpartum pain of body.
In order to realize foregoing invention object, the invention provides a kind of Chinese medicine for the treatment of blood-deficiency type postpartum pain of body, its featureBe, comprise following raw medicinal material: the Radix Astragali, chrysanthemum ginseng, lichee, broadleaf sedge root, densehead mountainash fruit, sieve bean, common embelia fruit, Ligusticum wallichii, the root of herbaceous peony,Saline cistanche, Radix Angelicae Sinensis, yunnan craibiodendron leaf, prepared rhizome of rehmannia, cutworm, dried scallop, exceedingly high candle, tall rattlesnake plantain herb, ventilago leiocarpa, reticulate millettia, chicken bone bavin, Lu ZiRattan, glabrousleaf pittosporum root, delavay violet root, sinomenium acutum, cassia twig, river cassia bark, Chinese elm stem, Poria cocos, blood aspidistra, glossy ganoderma and wilsonii.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Astragali 21-34 part, chrysanthemum ginseng 11-26 part, lichee 16-28 parts, broadleaf sedge root 8-17 part, densehead mountainash fruit 14-25 part, sieve bean 9-18 part, common embelia fruit 10-21 part, Ligusticum wallichii 16-32 part, the root of herbaceous peony12-25 part, saline cistanche 7-15 part, Radix Angelicae Sinensis 21-36 part, yunnan craibiodendron leaf 3-7 part, prepared rhizome of rehmannia 22-38 part, cutworm 10-21 part, dried scallop13-28 part, exceedingly high candle 9-19 part, tall rattlesnake plantain herb 16-30 part, ventilago leiocarpa 11-21 part, reticulate millettia 26-40 part, chicken bone bavin 21-37Part, false nettleleaf pepper herb 11-20 part, glabrousleaf pittosporum root 13-24 part, delavay violet root 18-28 part, sinomenium acutum 9-17 part, cassia twig 8-15 part, river cassia bark12-21 part, Chinese elm stem 10-19 part, Poria cocos 23-39 part, blood aspidistra 11-20 part, glossy ganoderma 24-40 part and wilsonii 14-25 part.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: Radix Astragali 24-30 part, chrysanthemum ginseng 15-22 part, lichee 19-24 parts, broadleaf sedge root 10-15 part, densehead mountainash fruit 17-21 part, sieve bean 11-16 part, common embelia fruit 13-19 part, Ligusticum wallichii 19-28 part, the root of herbaceous peony15-21 part, saline cistanche 9-13 part, Radix Angelicae Sinensis 25-32 part, yunnan craibiodendron leaf 4-6 part, prepared rhizome of rehmannia 26-35 part, cutworm 12-18 part, dried scallop16-24 part, exceedingly high candle 11-17 part, tall rattlesnake plantain herb 19-26 part, ventilago leiocarpa 14-19 part, reticulate millettia 29-35 part, chicken bone bavin 25-33Part, false nettleleaf pepper herb 13-17 part, glabrousleaf pittosporum root 16-21 part, delavay violet root 20-25 part, sinomenium acutum 11-15 part, cassia twig 10-13 part, river cassia bark15-19 part, Chinese elm stem 12-17 part, Poria cocos 26-33 part, blood aspidistra 13-17 part, glossy ganoderma 28-35 part and wilsonii 17-21 part.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 30 parts of the Radixs Astragali, 15 parts of chrysanthemum ginsengs, 24 parts of lichee, precipice palm fibre10 parts of roots, 19 parts of densehead mountainash fruits, 11 parts of sieve beans, 13 parts of common embelia fruits, 28 parts of Ligusticum wallichiis, 21 parts of the root of herbaceous peonys, 9 parts of saline cistanches, 32 parts of Radix Angelicae Sinensis,4 parts of yunnan craibiodendron leafs, 35 parts of prepared rhizomes of rehmannia, 12 parts of cutworms, 21 parts, dried scallop, 11 parts, exceedingly high candle, 26 parts of tall rattlesnake plantain herbs, 14 parts of ventilago leiocarpas, chicken35 parts, blood rattan, 25 parts of chicken bone bavins, 13 parts of false nettleleaf pepper herbs, 18 parts of glabrousleaf pittosporum roots, 25 parts of delavay violet roots, 11 parts of sinomenium acutums, 10 parts of cassia twig, osmanthus, river18 parts of 19 parts of skins, 12 parts, Chinese elm stem, 33 parts, Poria cocos, 13 parts of blood aspidistras, 35 parts of glossy ganodermas and wilsoniis.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 27 parts of the Radixs Astragali, 22 parts of chrysanthemum ginsengs, 19 parts of lichee, broadleaf sedge root 12Part, 17 parts of densehead mountainash fruits, 14 parts of sieve beans, 19 parts of common embelia fruits, 25 parts of Ligusticum wallichiis, 15 parts of the root of herbaceous peonys, 13 parts of saline cistanches, 27 parts of Radix Angelicae Sinensis, gold5 parts, leaf, 26 parts of prepared rhizomes of rehmannia, 15 parts of cutworms, 24 parts, dried scallop, 17 parts, exceedingly high candle, 22 parts of tall rattlesnake plantain herbs, 16 parts of ventilago leiocarpas, chicken blood29 parts, rattan, 33 parts of chicken bone bavins, 15 parts of false nettleleaf pepper herbs, 21 parts of glabrousleaf pittosporum roots, 22 parts of delavay violet roots, 15 parts of sinomenium acutums, 13 parts of cassia twig, river cassia bark17 parts of 17 parts, 14 parts, Chinese elm stem, 26 parts, Poria cocos, 17 parts of blood aspidistras, 32 parts of glossy ganodermas and wilsoniis.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is: 24 parts of the Radixs Astragali, 18 parts of chrysanthemum ginsengs, 21 parts of lichee, broadleaf sedge root 15Part, 21 parts of densehead mountainash fruits, 16 parts of sieve beans, 15 parts of common embelia fruits, 19 parts of Ligusticum wallichiis, 17 parts of the root of herbaceous peonys, 11 parts of saline cistanches, 25 parts of Radix Angelicae Sinensis, gold6 parts, leaf, 30 parts of prepared rhizomes of rehmannia, 18 parts of cutworms, 16 parts, dried scallop, 14 parts, exceedingly high candle, 19 parts of tall rattlesnake plantain herbs, 19 parts of ventilago leiocarpas, chicken blood32 parts, rattan, 28 parts of chicken bone bavins, 17 parts of false nettleleaf pepper herbs, 16 parts of glabrousleaf pittosporum roots, 20 parts of delavay violet roots, 13 parts of sinomenium acutums, 11 parts of cassia twig, river cassia bark21 parts of 15 parts, 17 parts, Chinese elm stem, 30 parts, Poria cocos, 15 parts of blood aspidistras, 28 parts of glossy ganodermas and wilsoniis.
When the formulation of described Chinese medicine is decoction, its preparation method comprises the following steps:
Step 1: described raw medicinal material is mixed and puts into purple casserole, add clear water, soaked medicinal material upper surface 2-5cm to clear water,Soak 3-10 hour;
Step 2: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 30-50 minute, filter, obtain filtrate a, standbyWith;
Step 3: the residue dregs of a decoction are added to clear water again, soaked medicinal material upper surface 2-3cm to clear water, soak 3-10 hour;
Step 4: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly the 25-35 minute dosage to liquid and be100-300ml, filters, and obtains filtrate b, and filtrate a and filtrate b are mixed.
When the formulation of described Chinese medicine is lotion, its preparation method comprises the following steps:
The first step, mixes described raw medicinal material in proportion, puts into micronizer and is ground into 0.1~10 μ m volume averaging grainThe micron particles in footpath and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μ m volume average particle size, described mixingThe powder rate that obtains of powder is at least 95%;
Second step, adds the determining alcohol with respect to 3~5 times of the quality of described mixed powder in the first step in the mixed powder obtainingBe 85%~95% ethanol, stirring and dissolving obtains ethanolic solution, and ethanolic solution is left standstill to 24~36 under the condition of 5 DEG C~10 DEG CHour, adopt the speed slowly diacolation of percolation with 1~2ml per minute, collect percolate, concentrate and be dried, and put at thisIn micronizer, pulverize 40~60 minutes, the micron particles and the particle diameter that obtain 0.1~10 μ m volume average particle size are less than 0.1The mixed powder of the nano-scale particle composition of μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
The 3rd step, adds deionized water with respect to mixed powder quality 2~3 times in the mixed powder obtaining at second step, decoctsBoil 2~4 hours, filter, obtain lotion.
When the formulation of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step by the Radix Astragali, chrysanthemum ginseng, lichee, broadleaf sedge root, densehead mountainash fruit, sieve bean, common embelia fruit, Ligusticum wallichii and the root of herbaceous peony in described ratioMix, add with respect to the water extraction of 4~6 times, mixture and get volatile oil, by obtain volatile oil beta-cyclodextrin inclusion compound, volatile oil andThe mass ratio of beta-schardinger dextrin-is 1: 3~6, stirs 60 minutes~90 minutes, and 30 DEG C~50 DEG C of temperature, obtain volatile oil clathrate compound,For subsequent use; The clear cream that while separately aqueous extract being concentrated into 60 DEG C, relative density is 1.15~1.17;
Second step, by saline cistanche, Radix Angelicae Sinensis, yunnan craibiodendron leaf, prepared rhizome of rehmannia, cutworm, dried scallop, exceedingly high candle, tall rattlesnake plantain herb, ventilago leiocarpa and chicken bloodRattan mixes in described ratio, and the alcohol reflux that to add with respect to 5~8 times, mixture amount determining alcohols be 75%~90% extracts 3~5 times,Each 2~3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, and while being concentrated into 60 DEG C, relative density is 1.20~1.22Clear cream, for subsequent use;
The 3rd step, will remain described raw medicinal material and mix in described ratio, add with respect to 8~10 times of water gagings of mixture, boil 6~8 hours, filter the clear cream that while being concentrated into 60 DEG C, relative density is 1.28~1.30;
The 4th step, mixes the clear cream of the first step, second step, the 3rd step, and 60 DEG C~70 DEG C reduced vacuum are dry, and powder gets dry extract;
The 5th step, fully mixes dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step, add subsequently with respect toThe mixture of volatile oil clathrate compound and dried cream powder described in 100 weight portions, 5~7 weight portion sodium carboxymethyl starches, 5~50 weight portionsStarch mixes, and adding 150~200 weight portion determining alcohols is 80%~90% alcohol granulation, dry, and whole grain, adds phase subsequentlyFor the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3~5 weight portion dolomols, then pack gelatin intoIn capsule.
For solving the problems of the technologies described above, the invention provides a kind of formulation of Chinese medicine preparation for the treatment of blood-deficiency type postpartum pain of body,Pharmaceutical dosage form can be: tablet, film coated tablet, capsule, sugar coated tablet, hard capsule, soft capsule, suck agent, particleAgent, enteric coated tablet, electuary, honey pill agent, oral liquid, powder, solution, sublimed preparation, suppository, emplastrum, syrup, injection,Powder.
The beneficial effect that technical scheme provided by the invention is brought is: the present invention has the treatment for the treatment of blood-deficiency type postpartum pain of bodyPrognosis is better, on the basis of seeing, is particular about diagnosis and treatment at animal economy, selected fully natural green medicinal material, and the drug effect focus of going directly, controlsTreat the course for the treatment of shorter, curative effect is better, and toxic and side effect is less, has no adverse reaction, and in treatment, this also has very postpartum depression in sickGood curative effect, can play certain health-care effect to body, and cost price is cheap, and manufacture craft is simple, can carry out clinical pushing awayExtensively meet the feature of the Treatment need of clinical postpartum disease.
Detailed description of the invention
Motherland's medical science thinks, it is mainly due to deficiency of qi and blood in postpartum that postpartum pain of body occurs, and passages through which vital energy circulates loses supports or plain body deficiency of the kidney, born of the same parentsArteries and veins loses supports, and postpartum battalion defends imbalance, interspaces of skin and muscles being loose, and the damp evil that is affected by the cold, makes due to QI-blood circulation is obstructed. Therefore, the present inventionTreatment blood-deficiency type postpartum pain of body select the Radix Astragali, chrysanthemum ginseng, lichee, broadleaf sedge root, densehead mountainash fruit, sieve bean, common embelia fruit, Ligusticum wallichii, the root of herbaceous peony,Saline cistanche, Radix Angelicae Sinensis, yunnan craibiodendron leaf, prepared rhizome of rehmannia, cutworm, dried scallop, exceedingly high candle, tall rattlesnake plantain herb, ventilago leiocarpa, reticulate millettia, chicken bone bavin, Lu ZiRattan, glabrousleaf pittosporum root, delavay violet root, sinomenium acutum, cassia twig, river cassia bark, Chinese elm stem, Poria cocos, blood aspidistra, glossy ganoderma and wilsonii.
Wherein, the pharmacology of above-mentioned raw materials medicinal material is as follows:
The Radix Astragali: this product is the dry root of legume astragalus mongolicus or Astragalus membranacus. Spring, Qiu Erji excavate, and remove fibrous root and rootHead, dries. Sweet, temperature. Return lung, the spleen channel. Invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, expelling pus and promoting granulation.
Fern fiber crops: another name panax ginseng fruit, lotus cauliflower, the fruit of lengthening the life. Rose family potentilla plants potentilla anserina, enters with piece rootMedicine. Excavate summer, cleans and dry. Sweet, flat. Fill blood, strengthening the spleen and stomach, promotes the production of body fluid to quench thirst, dampness removing.
Ligusticum wallichii: rhizome of chuanxiong Qiong, leaflet Ligusticum wallichii. This product is the dry rhizome of samphire Ligusticum wallichii. The joint dish of working as summer on stem showsOutstandingly, and slightly excavate when purple, remove silt, after shining, a heatable brick bed is dry, then removes fibrous root. Pungent, temperature. Return liver, courage, pericardium channel. Invigorate blood circulationPromoting the circulation of qi, wind-expelling pain-stopping.
The root of herbaceous peony: another name Chinese herbaceous peony. This product is the dry root of ranunculaceae plant Chinese herbaceous peony. Summer, Qiu Erji excavate, and clean, except decaptitatingTail and radicula, put after removing crust or peeling after boiling in boiling water and boil, dries. Bitter, sour, be slightly cold. Return liver, the spleen channel. Flat liver pain relieving,Nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Prepared rhizome of rehmannia: the Preparation process product that this product is radix rehmanniae recen. Sweet, tepor. Return liver, kidney channel. Nourishing yin and supplementing blood, beneficial essence is filled out marrow.
Cutworm: call native CORDYCEPS, white CORDYCEPS, white Chinese caterpillar fungus, tuberculosis grass. Labiatae betony cutworm, is used as medicine with stem tuber.Adopt autumn, cleans using fresh herb or cook and dry. Sweet, flat. Kidney-nourishing moistening lung, nourishing yin and supplementing blood, clearing heat and relieving fidgetness.
Saline cistanche: the fleshy stem of the dry zone scale leaf that this product is orobanchaceae plant cistanche. More than spring seedling be not unearthed orWhile being just unearthed, excavate, remove inflorescence, segment, dries. Sweet, salty, temperature. Return kidney, large intestine channel. Kidney-replenishing, benefiting essence-blood, relaxes bowel.
Dried scallop: another name dried scallop, scallop post. For Pectenidae animal Chlamys farreri, Chlamys nobilis and flower magpie comb hole fanThe closed shell flesh of shellfish. Taste is sweet; Salty; Slightly warm in nature. Enriching yin; Nourish blood; Kidney tonifying; In tune.
Tall rattlesnake plantain herb: another name Shi Fengdan, Orchid. For the complete stool of orchid Goodyera procera. Gather winter. Toil, temperature.Dispel rheumatism, blood-nourishing myospasm relaxing.
Ventilago leiocarpa: another name blood wind root, smoothfruit ventilago root and stem, red serpentaria, blue veins rattan, car pusher enter stone, draw ox to enter stone. Rhamnaceae ventilago leiocarpaPlatymiscium ventilago leiocarpa, is used as medicine with root. Can adopt the whole year, cleans section, dries. Hardship, temperature. Nourishing the blood to expel wind, stimulates the circulation of the blood and cause the muscles and joints to relax.
Lichee: another name Dali, red litchi. Sapindaceae lichee platymiscium litchi, is used as medicine with aril (pulp). Summer autumn harvest collection, dries.Sweet, sour, temperature. Blood-enrich.
Chrysanthemum ginseng: another name Mao Yecao. For the herb of the false sharp stamen of acanthaceous plant adhesive hair. Taste is micro-sweet; Property is put down. Blood-enrich.
Broadleaf sedge root: another name xeromenia grass. For the root of sedge sesame leaf sedge. Taste is sweet; Pungent; Warm in nature. Lung; Liver; Kidney channel. Benefit gas is supportedBlood; Promoting blood circulation for regulating menstruation.
Densehead mountainash fruit: another name glutinous rice pearl. For the fruit of rosaceous plant Sorbus alnifolia. Sweet; Flat. Spleen; Liver. Qi-restoratives nourishes blood.
Reticulate millettia: another name blood wind, blood rattan, sargentodoxa cuneata, smoothfruit ventilago root and stem, three leaf reticulate millettias, nine layers of wind. This product is that legume is closeThe dry rattan of flower beans (sargentodoxa cuneata, smoothfruit ventilago root and stem, three leaf reticulate millettias, nine layers of wind). Autumn, two seasons of winter gather, and remove branches and leaves, section,Dry. Bitter, sweet, temperature. Return liver, kidney channel. Enrich blood, invigorate blood circulation, dredging collateral.
Exceedingly high candle: another name wood fungus, native desert cistanche. For the herb of Balanophoraceae plant polyandrous balanophora herb. Bitter; Micro-puckery; Property is put down.Clearing heat and detoxicating; Nourishing yin and nourishing blood; Hemostasis.
Radix Angelicae Sinensis: the dry root that this product is umbelliferae angelica. Autumn end excavates, and removes fibrous root and silt, treats that moisture slightly steamsAfter sending out, be bundled into wisp, upper canopy, with slowly smoke-dried beancurd of pyrotechnics. Sweet, acrid, warm. Return liver, the heart, the spleen channel. Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, profitIntestines defaecation.
Sieve bean: another name Yellow Emperor, a legendary ruler beans, multicolored beans. For the seed of legume sieve bean. Taste is sweet; Bitter; Property is put down. Liver Channel. MendBlood; Invigorate blood circulation; Detumescence.
Common embelia fruit: another name Suan Jiang, sour rattan head. For the fruit of Myrsinacea plant common embelia fruit. Gather summer, cooks, and shinesDry for subsequent use. Acid is sweet, flat. Strong enriching blood.
Yunnan craibiodendron leaf: another name dog pin grass, minx, Psoralen spirit, numb louse, horse louse, internal lesion caused by overexertion leaf, the false Schima superba in Yunnan, YunnanGram Lei wood. Ericaceae cuneateleaf meliosma platymiscium Yunnan cuneateleaf meliosma, is used as medicine with leaf. Winter in the Summer Solstice gathers, and dries or using fresh herb. It is pungent, puckery,Temperature. Blood stasis removing analgesic, dispels rheumatism, and stops blooding sensible.
Chicken bone bavin: the two Xiang grass of another name, grandma, thin dog return to life from the nether world grass, orangeeye butterflybush branchlet and leaf or root-bark, purple oil Soviet Union. Labiatae chicken bone bavin, with rootBe used as medicine. Hardship, temperature. Warming and activating meridian, dispels rheumatism.
False nettleleaf pepper herb: another name leaf orchid, Lu Zilan, ramie leaf beach wormwood, wild pepper, large Herba Piperris Tonkinensis. For Piperaceae plant folium urticae HuThe complete stool of green pepper. Autumn, winter gather. Clean chopping is dried. Pungent, temperature. Stimulate the circulation of the blood and cause the muscles and joints to relax, warm through dampness removing, promoting qi circulation and relieving pain.
Glabrousleaf pittosporum root: be root or the root skin of Pittosporaceae plant Pittosporum glabratum Lindl.. Autumn Mo gathers. Sweetness and bitterness is pungent, cool. Tonifying lung kidney, dispelsRheumatism, promoting blood circulation and removing obstruction in channels.
Sinomenium acutum: another name is sought wind rattan, Sabia japonica, the Yunnan root of fangji, Fructus Aristolochiae Kwangsiensis, large sinomenium acutum, rock and seen anxious, air draft rattan, siphon, sheepSparrow wood, drum rattan, beanpod rattan, broadleaf globethistle inflorescence, climb ground maple, the hair root of fangji, the blue or green root of fangji, wind dragon, bitter rattan, the black root of fangji, oblongleaf kadsura stem or root, chase after bone loose,Soil rattan. For the rattan of menispermaceous plants sinomenium acutum or hair sinomenium acutum. Bitter; Pungent; Flat. Liver; The spleen channel. Dispelling wind and removing obstruction in the meridians; Damp dispelling and pain relieving.
Delavay violet root: call the native root of Chinese wild ginger. For the root of Violaceae plant bastard indigo violet. Autumn, winter excavate, and clean and dry. Acid is sweet,Temperature. Warming and activating meridian, damp dispelling and pain relieving.
Cassia twig: this product is the dry spray of canella Chinese cassia tree. Spring, Xia Erji gather, and except defoliation, dry, or section are shoneDry. Acrid, sweet, warm. The thoughts of returning home, lung, urinary bladder channel. Sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, the flat gas that spins.
River cassia bark: be the bark of canella Cinnamomum mairei Levl.. Pungent; Sweet; Temperature. Warming channel and expelling cold; The promoting flow of qi and blood circulation; Pain relieving.
Chinese elm stem: another name chicken is raised young stem. For the stem of Ulmaceae Chinese elm. Sweet; Micro-hardship; Cold in nature. Remove obstruction in channels to relieve pain.
Wilsonii: this product is dry, root and rhizome or the stem of Araliaceae wilsonii. Spring, Qiu Erji gather, clean,Dry. Pungent, micro-hardship, temperature. Return spleen, kidney, the heart channel of Hang-Shaoyin. Replenish qi to invigorate the spleen, tonify the kidney to relieve mental strain.
Glossy ganoderma: another name polyporus lucidus, Ganoderma, Ganoderma Lucidum. This product is that the dry son of the red sesame of On Polyporaceae or purple sesame is realBody. Gather the whole year, removes impurity, wipes out the lower end stem with rotten wood, silt or culture matrix, dries in the shade or 40~50 DEG C of bakingsDry. Sweet, flat. The thoughts of returning home, lung, liver, kidney channel. Invigorating qi for tranquilization, relieving cough and asthma.
Blood aspidistra: another name discolor ludisia herb, cadbait, very golden grass, heterochromatic blood aspidistra. For the herb of orchid blood aspidistra. Taste is sweet;Cool in nature. Nourishing Yin and moistening lung; Invigorating the spleen; Calm the nerves.
Poria cocos: another name Poria cocos, fuling peel, Poria cocos piece, poria cocos, PORIA ALBA. This product is On Polyporaceae Poria cocosDry sclerotia. More than excavating for 7~September, after digging out, remove silt, bank up after " sweating ", spread out and dry in the air to dry tack free, then " send outSweat ", after extremely now wrinkle, the large portion of internal moisture scatter and disappear for several times repeatedly, dry in the shade, be called " Poria cocos "; Or fresh Poria cocos is pressed to different portionsPosition cutting, dries in the shade, and is called " fuling peel " and " Poria cocos piece ". Sweet, light, flat. The thoughts of returning home, lung, spleen, kidney channel. Clearing damp and promoting diuresis, strongThe peaceful heart of spleen.
Below adopt embodiment to describe embodiments of the present invention in detail, whereby to how application technology means of the present inventionSolve technical problem, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 decoction of the present invention
Get Radix Astragali 30g, chrysanthemum ginseng 15g, lichee 24g, broadleaf sedge root 10g, densehead mountainash fruit 19g, sieve bean 11g, common embelia fruit 13g, Ligusticum wallichii28g, root of herbaceous peony 21g, saline cistanche 9g, Radix Angelicae Sinensis 32g, yunnan craibiodendron leaf 4g, prepared rhizome of rehmannia 35g, cutworm 12g, dried scallop 21g, exceedingly high candle 11g,Tall rattlesnake plantain herb 26g, ventilago leiocarpa 14g, reticulate millettia 35g, chicken bone bavin 25g, false nettleleaf pepper herb 13g, glabrousleaf pittosporum root 18g, delavay violet root 25g, sinomenium acutum11g, cassia twig 10g, river cassia bark 19g, Chinese elm stem 12g, Poria cocos 33g, blood aspidistra 13g, glossy ganoderma 35g and wilsonii 18g.
Its preparation method comprises the following steps:
Step 1: described raw medicinal material is mixed and puts into purple casserole, add clear water, soaked medicinal material upper surface 3cm to clear water, soakSteep 3 hours;
Step 2: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 50 minutes, filter, obtain filtrate a, for subsequent use;
Step 3: the residue dregs of a decoction are added to clear water again, soaked medicinal material upper surface 3cm to clear water, soak 4 hours;
Step 4: purple casserole is placed in to fire upper, after intense fire boils, using slow fire instead, to decoct slowly the 30 minutes dosage to liquid be 300ml,Filter, obtain filtrate b, filtrate a and filtrate b are mixed.
Embodiment 2 lotion of the present invention
Get Radix Astragali 27g, chrysanthemum ginseng 22g, lichee 19g, broadleaf sedge root 12g, densehead mountainash fruit 17g, sieve bean 14g, common embelia fruit 19g, Ligusticum wallichii25g, root of herbaceous peony 15g, saline cistanche 13g, Radix Angelicae Sinensis 27g, yunnan craibiodendron leaf 5g, prepared rhizome of rehmannia 26g, cutworm 15g, dried scallop 24g, exceedingly high candle 17g,Tall rattlesnake plantain herb 22g, ventilago leiocarpa 16g, reticulate millettia 29g, chicken bone bavin 33g, false nettleleaf pepper herb 15g, glabrousleaf pittosporum root 21g, delavay violet root 22g, sinomenium acutum15g, cassia twig 13g, river cassia bark 17g, Chinese elm stem 14g, Poria cocos 26g, blood aspidistra 17g, glossy ganoderma 32g and wilsonii 17g.
Its preparation method comprises the following steps:
The first step, mixes described raw medicinal material in proportion, puts into micronizer and is ground into the micro-of 5 μ m volume average particle sizeMeter level particle and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μ m volume average particle size, described mixed powderObtain powder rate and be at least 95%;
Second step, adds with respect to the determining alcohol of 4 times of the quality of described mixed powder in the mixed powder obtaining to be in the first step95% ethanol, stirring and dissolving obtains ethanolic solution, and ethanolic solution is left standstill to 36 hours under the condition of 10 DEG C, adopts percolationWith the slowly diacolation of speed of 2ml per minute, collect percolate, concentrate and be dried, and put into micronizer at this and pulverize 60Minute, the micron particles of acquisition 5 μ m volume average particle size and particle diameter are less than the nano-scale particle group of 0.1 μ m volume average particle sizeThe mixed powder becoming, the powder rate that obtains of described mixed powder is at least 95%;
The 3rd step, in the mixed powder obtaining at second step, add with respect to 3 times of mixed powder quality go dried uply, decoct 3 littleTime, filter, obtain lotion.
Embodiment 3 capsule of the present invention
Get Radix Astragali 24g, chrysanthemum ginseng 18g, lichee 21g, broadleaf sedge root 15g, densehead mountainash fruit 21g, sieve bean 16g, common embelia fruit 15g, Ligusticum wallichii19g, root of herbaceous peony 17g, saline cistanche 11g, Radix Angelicae Sinensis 25g, yunnan craibiodendron leaf 6g, prepared rhizome of rehmannia 30g, cutworm 18g, dried scallop 16g, exceedingly high candle 14g,Tall rattlesnake plantain herb 19g, ventilago leiocarpa 19g, reticulate millettia 32g, chicken bone bavin 28g, false nettleleaf pepper herb 17g, glabrousleaf pittosporum root 16g, delavay violet root 20g, sinomenium acutum13g, cassia twig 11g, river cassia bark 15g, Chinese elm stem 17g, Poria cocos 30g, blood aspidistra 15g, glossy ganoderma 28g and wilsonii 21g.
Its preparation method comprises the following steps:
The first step by the Radix Astragali, chrysanthemum ginseng, lichee, broadleaf sedge root, densehead mountainash fruit, sieve bean, common embelia fruit, Ligusticum wallichii and the root of herbaceous peony in described ratioMix, add with respect to the water extraction of 5 times, mixture and get volatile oil, by the volatile oil beta-cyclodextrin inclusion compound obtaining, volatile oil and β-The mass ratio of cyclodextrin is 1: 5, stirs 60 minutes, and temperature 50 C, obtains volatile oil clathrate compound, for subsequent use; Separately that aqueous extract is denseThe clear cream that while being reduced to 60 DEG C, relative density is 1.17;
Second step, by saline cistanche, Radix Angelicae Sinensis, yunnan craibiodendron leaf, prepared rhizome of rehmannia, cutworm, dried scallop, exceedingly high candle, tall rattlesnake plantain herb, ventilago leiocarpa and chicken bloodRattan mixes in described ratio, and the alcohol reflux that to add with respect to 8 times, mixture amount determining alcohols be 90% extracts 4 times, and each 3 hours, pointNot Guo Lv, each filtrate merges, and reclaims ethanol, the clear cream that while being concentrated into 60 DEG C, relative density is 1.22 is for subsequent use;
The 3rd step, will remain described raw medicinal material and mix in described ratio, add with respect to 9 times of water gagings of mixture, boil 7 hours,Filter the clear cream that while being concentrated into 60 DEG C, relative density is 1.30;
The 4th step, mixes the clear cream of the first step, second step, the 3rd step, and 70 DEG C of reduced vacuum are dry, and powder gets dry extract;
The 5th step, fully mixes dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step, add subsequently with respect toThe mixture of volatile oil clathrate compound and dried cream powder described in 100 weight portions, 6 weight portion sodium carboxymethyl starches, 40 weight portion starch mixClose evenly, adding 180 weight portion determining alcohols is 90% alcohol granulation, dry, and whole grain, adds subsequently with respect to described in 100 weight portionsThe mixture of volatile oil clathrate compound and dried cream powder, 4 weight portion dolomols, then pack in gelatine capsule.
Acute skin irritation test:
These product are according in the Ministry of Public Health's " cosmetics health specification " (2002) Part II " skin irritation/corrosion test " 6.3Joint, male 4 of Japan large ear rabbit, body weight 2kg~3kg, lotion prepared by embodiments of the invention 2 is directly coated in an animal left sideOn side skin (opposite side is in contrast), adopt blocking test, 4 hours application time, residual with warm water washing after off-testTested material, after removing tested material, 1h, 24h, 48h and 72h observe respectively the dermoreaction of the tested district of animal and check plot, the highestIntegral mean value is " 0 ", judges that these product are to animal skin nonirritant.
Hypersensitive test:
Get 18 of healthy albino guinea-pigs, body weight 250-300g, male and female dual-purpose, rejects both sides dorsal body setae before test, every side 3 × 3cm, withMachine is divided into test group, blank group (matrix) and positive controls. Positive controls DNFB, sensitization is used1% concentration, excites and uses 0.1% concentration; The lotion of the embodiment of the present invention 2 for test group. The lotion of the embodiment of the present invention 2 is applied toUnhairing district, back, the next day 1 time, totally 3 times. Contact latter 14 days in last, be coated with washing of the embodiment of the present invention 2 at back the same areaAgent, removes after 6h after medicine and at once observes, and in 24,48,72h observes and has or not allergic reaction. Blank group and positive controlGroup uses same method excite contact and observe. Result of the test: positive controls animal skin occurs after 1 hour that in sensitization limitation is redSpot and slight oedema, within 24 hours, symptoms of allergic increases the weight of, and has scleroma to form, and sensitization rate is 100%, test group and blank rightAll do not occur any symptoms of allergic according to treated animal skin, sensitization rate is 0%.
Acute toxicity test:
40 of application NIH mouse, SPF level, male and female half and half, body weight 18~22g, carries out acute toxicity test. Mouse is divided at randomTwo groups, 20 every group, i.e. control group and administration group, fasting 12 hours before experiment; Decoction prepared by embodiments of the invention 1,(concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume be 5ml/kg(be single-dose dosage be 32.9 crude drugs/Kg), control group gives equivalent physiological saline, administration in a day 2 times, and delivery time 6 hours, Continuous Observation 14 days after administration,And record mouse toxic reaction and death toll. Experimental result shows: with control group comparison, after administration, mouse has no obviously poorDifferent, experiment Continuous Observation 14 days, mouse overall health of patients, diet, drinking-water, body weight gain are all normal. The present invention of mouse oral administration gavageDecoction LD50 > 32.9 crude drugs/kg, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day. Chinese medicine clinical application amount of the present inventionFor 4.4g crude drug/day/people, become body weight for humans in 60KG, average dosage is 0.073g crude drug/kg/ day. Press batheroom scale: littleThe dosis tolerata of mouse (average weight is taking 20g) oral administration gavage Chinese medicine of the present invention is 901 times of quantity. Therefore the present invention is realThe decoction acute toxicity of executing example 1 is low, clinical drug safety.
Long term toxicity test:
The capsule of the embodiment of the present invention 3 to mouse by 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks(1.0ml/100g body weight, every day 2 times) and drug withdrawal are after 4 weeks, and result shows: hair, behavior, the size of Chinese medicine of the present invention to mouseJust, the index such as body weight, organ weights, blood picture, hepatic and renal function, blood sugar, blood fat all has no significant effect, internal organs naked eyes are not found differentSample changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing. This is describedThe capsule of inventive embodiments 3 to mouse long-term prescription after toxicity little, after drug withdrawal, there is no difference reaction, application safety yet.
Clinical data:
This group case is the patient that clinic case is suffered from postpartum pain of body, totally 120 examples, wherein age reckling 24 years old, the maximum 40Year, 28 years old mean age. The first tire example in postpartum 85, second fetus example in postpartum 35, natural labor 98 examples, caesarean birth 22 examples; The course of disease is being producedPerson's 30 examples within rear January, 1~March person's 35 examples, 3~June person's 40 examples, June above person's 15 examples; Be divided at random:
Decoction treatment group: 31 people.
Lotion for treatment group: 30 people.
Capsule treatment group: 30 people.
Control group: 29 people.
Diagnostic criteria:
Western medicine diagnose standard
(1) there is the time of producing more or lose blood postpartum more;
(2) puerpera's arthralgia all over, extremity numbness, dizzy palpitaition;
(3) joint pain that should demonstrate,prove with impotence, rheumatism bi Zheng etc. causes is differentiated mutually.
Wherein, arthralgia all over, limbs are miserable, numb, dizzy palpitaition, arteries and veins thin and delicate dialectical be blood-deficiency type postpartum pain of body.
Methods for the treatment of:
Decoction treatment group: the decoction that uses the embodiment of the present invention 1 to prepare, 7 days is 1 course for the treatment of at 1 dose of every day.
Lotion for treatment group: the lotion that uses the embodiment of the present invention 2 to prepare, 7 days is 1 course for the treatment of at every day 1 time.
Capsule treatment group: the capsule that uses the embodiment of the present invention 3 to prepare, every day 3 times, each 67 days is 1 treatmentJourney.
Control group: use " Chanhouning " capsule, main ingredients: the Radix Astragali, prepared RADIX ANGELICAE SINENSIS with yellow rice wine, the root of fangji, bark of ash, windproof, cassia twig, thinPungent, peach kernel, dragon's blood, Radix Glycyrrhizae etc., 0.5 gram every, each 5, every day 3 times, warm water delivery service, 7 days 1 courses for the treatment of.
Efficacy assessment standard:
Recovery from illness: the symptom functional rehabilitation that all disappears is normal;
Effective: cardinal symptom disappears substantially, limbs pain obviously alleviates, and function of joint is recovered normal person substantially;
Effective: symptom alleviates, the incomplete recuperator of function;
Invalid: pain, without obviously alleviating, has no improvement person after treatment.
Treatment results:
Referring to table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs blood-deficiency type postpartum pain of body of the present invention, with respect to contrastGroup, in result for the treatment of, has significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs blood-deficiency type body in postpartum of the present inventionBitterly, with respect to control group, treating significantly shortening on the course for the treatment of.
Four groups, table 1 is treated respectively Clinical efficacy comparison example after 4 courses for the treatment of
Group Number of cases Recovery from illness Effective Effectively Invalid Total effective rate
Decoction treatment group 31 29 2 0 0 100%
Lotion for treatment group 30 27 2 1 0 100% 8 -->
Capsule treatment group 30 28 1 1 0 100%
Control group 29 17 5 3 4 86.2%
Four groups, table 2 is treated respectively recovery from illness and effective number and time comparative example (%) after 4 courses for the treatment of
Group Number of cases 1-7 days 8-21 days 22-28 days
Decoction treatment group 31 7(22.6%) 18(58.1%) 6(19.4%)
Lotion for treatment group 29 5(17.2%) 19(65.5%) 5(17.2%)
Capsule treatment group 29 6(20.7%) 19(65.5%) 4(13.8%)
Control group 22 3(13.6%) 8(36.4%) 11(50.0%)
Known according to the clinical statistics in above table, Chinese medicine provided by the invention has rapid-action, efficient height, curative effect is trueCut, safe, the advantage that has no side effect; To the recovery from illness of decoction treatment group and 31 effective examples, lotion for treatment group is fully recovered simultaneouslyWith 29 effective examples, the recovery from illness of capsule treatment group and 29 effective examples, and control group is fully recovered and 22 effective routine patients follow up a case by regular visits to 2Year, result statistics:
Decoction treatment group is cured and 31 effective examples, and recovery from illness 29 examples are without recurrence, and 2 effective routine patients are without recurrence, and recurrence rate is 0%;
Lotion for treatment group is cured and 29 effective examples, and 27 examples of recovery from illness are without recurrence, and 2 effective routine patients are without recurrence, and recurrence rate is0%;
Capsule treatment group is cured and 29 effective examples, and 28 examples of recovery from illness are without recurring, and 1 effective routine patient is without recurrence, recurrence rateBe 0%;
Western medicine group is cured and 22 effective routine patients, and 17 examples of recovery from illness, without recurrence, recur 3 examples in 5 effective routine patients, multipleThe rate of sending out is 13.6%.
Model case:
Patient Lee, female, 27 years old, on July 12nd, 2014 examined, and after bearing child 25 days, occurred whole body pain, and limbs are miserable, warpTreat and do not feel any better after 40 days, dizzy palpitaition, arteries and veins is thin and delicate. Auxiliary examination: anti-" O " and Rheumatoid antibody are normal, and x-ray is taken the photograph sheet boneMatter no abnormality seen. This group is got rid of the illness such as rheumatism, rheumatoid disease, Osteoarthritis. Tcm diagnosis is postpartum pain of body, the dialectical blood that belongs toEmpty type. After patient takes 5 doses of the decoctions of embodiment 1, symptom subtracts greatly, and after 2 weeks, whole body pain disappear. Follow up a case by regular visits to not recurrence in 1 year.
In clinical testing, find, reflect that through patient medicine of the present invention has good improvement to post-natal depression. ThereforeCarry out contrast test.
This group case is the patient that clinic case is suffered from postpartum depression, totally 84 examples, wherein age reckling 23 years old, the maximum39 years old, 27 years old mean age. The first tire example in postpartum 62, second fetus example in postpartum 22, natural labor 71 examples, caesarean birth 13 examples; Random pointFor:
Decoction treatment group: 28 people.
Capsule treatment group: 27 people.
Control group: 29 people.
Diagnostic criteria
In 2 weeks postpartum, there are following 5 or 5 above symptoms. Wherein 1,2 indispensability. Morbidity is generally within 4 weeks postpartum.
1, be in a very depressed state;
2, to whole or most movable interest or joyful that obviously lacks;
3, body weight significantly declines or increases;
4, insomnia or hypersomnia;
5, psychomotor excitement or retardance;
6, tired or weak;
7, all feel meaningless when anything crops up or feel from crime;
8, thinking ability goes down or notice laxes;
9, repeatedly there is dead idea.
Methods for the treatment of:
Decoction treatment group: the decoction that uses the embodiment of the present invention 1 to prepare, 7 days is 1 course for the treatment of at 1 dose of every day.
Capsule treatment group: the capsule that uses the embodiment of the present invention 3 to prepare, every day 3 times, each 67 days is 1 treatmentJourney.
Western medicine group: take 1 day 50mg of amitriptyline sheet (every 25mg) and start, be incremented to 150mg by 7 day phase, dimensionHold medication 4 weeks.
Efficacy assessment standard:
Application HAMD scale is evaluated, respectively before medication, after medication 2 weeks and be respectively doomed for 4 weekends 1 time, by Measuring scale assessing. TreatEffect subtracts a point rate standard by HAMD, is divided into 4 grades:
Transference cure: HAMD subtracts a point rate > 75%;
Symptom is significantly improved: HAMD subtracts point rate 50% ~ 75%;
Symptom is improved: HAMD subtracts point rate 25% ~ 50%;
Invalid: HAMD subtracts point rate < 25%.
Treatment results:
Referring to table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs post-natal depression of the present invention, exist with respect to control groupIn result for the treatment of, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs post-natal depression of the present invention, with respect toControl group, is treating significantly shortening on the course for the treatment of.
Three groups, table 1 is treated respectively Clinical efficacy comparison example after 8 courses for the treatment of
Group Number of cases Transference cure Significantly improve Improve Invalid Total effective rate
Decoction treatment group 28 26 2 0 0 100%
Capsule treatment group 27 25 2 0 0 100%
Western medicine group 29 15 3 2 9 68.9%
Number and time comparative example (%) that three groups, table 2 is treated respectively transference cure after 8 courses for the treatment of and significantly improved
Group Number of cases 1-21 days 22-42 days 43-56 days
Decoction treatment group 28 7(25.0%) 18(64.3%) 3(10.7%)
Capsule treatment group 27 6(22.2%) 17(63.0%) 4(14.8%)
Western medicine group 18 2(11.1%) 7(38.9%) 9(50.0%)
Known according to the clinical statistics in above table, Chinese medicine provided by the invention has rapid-action, efficient height, curative effect is trueCut, safe, the advantage that has no side effect; Decoction treatment group transference cure and remarkable improvement 28 examples, capsule are controlled simultaneouslyTreatment group transference cure and 27 examples of significantly improving, and control group transference cure and the 18 routine patients that significantly improve follow up a case by regular visits to 2 years, knotFruit statistics:
Decoction treatment group transference cure and 28 examples of significantly improving, transference cure 26 examples are without recurrence, the 2 routine patients that significantly improve withoutRecurrence, recurrence rate is 0%;
Capsule treatment group transference cure and 27 examples of significantly improving, 25 examples of transference cure are without recurrence, and 2 examples of significantly improving are suffered fromPerson is without recurrence, and recurrence rate is 0%;
Western medicine group transference cure and the 18 routine patients that significantly improve, 15 example nothing recurrences of transference cure, 3 examples of significantly improvingIn patient, recur 2 examples, recurrence rate is 11.1%.
Can find out from above clinical data, medicine of the present invention is not only cured postpartum pain of body, and cure rate is high, rapid-action,And post-natal depression is had to good curative effect.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all in spirit of the present invention andWithin principle, any amendment of doing, be equal to replacement, improvement etc., within protection scope of the present invention all should be included in.

Claims (9)

1. a Chinese medicine for the treatment of blood-deficiency type postpartum pain of body, is characterized in that, comprises following raw medicinal material: the Radix Astragali, chrysanthemum ginseng, litchiBranch, broadleaf sedge root, densehead mountainash fruit, sieve bean, common embelia fruit, Ligusticum wallichii, the root of herbaceous peony, saline cistanche, Radix Angelicae Sinensis, yunnan craibiodendron leaf, prepared rhizome of rehmannia, cutworm, dried scallop,Exceedingly high candle, tall rattlesnake plantain herb, ventilago leiocarpa, reticulate millettia, chicken bone bavin, false nettleleaf pepper herb, glabrousleaf pittosporum root, delavay violet root, sinomenium acutum, cassia twig, river cassia bark,Chinese elm stem, Poria cocos, blood aspidistra, glossy ganoderma and wilsonii.
2. Chinese medicine according to claim 1, is characterized in that, in described Chinese medicine, the ratio of weight and number of each raw medicinal material is:Radix Astragali 21-34 part, chrysanthemum ginseng 11-26 part, lichee 16-28 part, broadleaf sedge root 8-17 part, densehead mountainash fruit 14-25 part, sieve bean 9-18Part, common embelia fruit 10-21 part, Ligusticum wallichii 16-32 part, root of herbaceous peony 12-25 part, saline cistanche 7-15 part, Radix Angelicae Sinensis 21-36 part, yunnan craibiodendron leaf 3-7Part, prepared rhizome of rehmannia 22-38 part, cutworm 10-21 part, dried scallop 13-28 part, exceedingly high candle 9-19 part, tall rattlesnake plantain herb 16-30 part, ventilago leiocarpa11-21 part, reticulate millettia 26-40 part, chicken bone bavin 21-37 part, false nettleleaf pepper herb 11-20 part, glabrousleaf pittosporum root 13-24 part, delavay violet root 18-28Part, sinomenium acutum 9-17 part, cassia twig 8-15 part, river cassia bark 12-21 part, Chinese elm stem 10-19 part, Poria cocos 23-39 part, blood aspidistra 11-20Part, glossy ganoderma 24-40 part and wilsonii 14-25 part.
3. Chinese medicine according to claim 1 and 2, is characterized in that, the ratio of weight and number of each raw medicinal material in described Chinese medicineFor: Radix Astragali 24-30 part, chrysanthemum ginseng 15-22 part, lichee 19-24 part, broadleaf sedge root 10-15 part, densehead mountainash fruit 17-21 part, sieve bean11-16 part, common embelia fruit 13-19 part, Ligusticum wallichii 19-28 part, root of herbaceous peony 15-21 part, saline cistanche 9-13 part, Radix Angelicae Sinensis 25-32 part, yunnan craibiodendron leaf4-6 part, prepared rhizome of rehmannia 26-35 part, cutworm 12-18 part, dried scallop 16-24 part, exceedingly high candle 11-17 part, tall rattlesnake plantain herb 19-26 part, the wingDrupe 14-19 part, reticulate millettia 29-35 part, chicken bone bavin 25-33 part, false nettleleaf pepper herb 13-17 part, glabrousleaf pittosporum root 16-21 part, delavay violet root20-25 part, sinomenium acutum 11-15 part, cassia twig 10-13 part, river cassia bark 15-19 part, Chinese elm stem 12-17 part, Poria cocos 26-33 part, blood leafBlue 13-17 part, glossy ganoderma 28-35 part and wilsonii 17-21 part.
4. according to the arbitrary described Chinese medicine of claim 1-3, it is characterized in that the parts by weight of each raw medicinal material in described Chinese medicineThan being: 30 parts of the Radixs Astragali, 15 parts of chrysanthemum ginsengs, 24 parts of lichee, 10 parts of broadleaf sedge roots, 19 parts of densehead mountainash fruits, 11 parts of sieve beans, common embelia fruit 13Part, 28 parts of Ligusticum wallichiis, 21 parts of the root of herbaceous peonys, 9 parts of saline cistanches, 32 parts of Radix Angelicae Sinensis, 4 parts of yunnan craibiodendron leafs, 35 parts of prepared rhizomes of rehmannia, 12 parts of cutworms, dried scallop 21Part, 11 parts, exceedingly high candle, 26 parts of tall rattlesnake plantain herbs, 14 parts of ventilago leiocarpas, 35 parts of reticulate millettias, 25 parts of chicken bone bavins, 13 parts of false nettleleaf pepper herbs, glabrousleaf pittosporum root18 parts, 25 parts of delavay violet roots, 11 parts of sinomenium acutums, 10 parts of cassia twig, 19 parts, river cassia bark, 12 parts, Chinese elm stem, 33 parts, Poria cocos, blood aspidistra 13Part, 18 parts of 35 parts of glossy ganodermas and wilsoniis.
5. according to the arbitrary described Chinese medicine of claim 1-4, it is characterized in that the parts by weight of each raw medicinal material in described Chinese medicineThan being: 27 parts of the Radixs Astragali, 22 parts of chrysanthemum ginsengs, 19 parts of lichee, 12 parts of broadleaf sedge roots, 17 parts of densehead mountainash fruits, 14 parts of sieve beans, common embelia fruit 19Part, 25 parts of Ligusticum wallichiis, 15 parts of the root of herbaceous peonys, 13 parts of saline cistanches, 27 parts of Radix Angelicae Sinensis, 5 parts of yunnan craibiodendron leafs, 26 parts of prepared rhizomes of rehmannia, 15 parts of cutworms, dried scallop 24Part, 17 parts, exceedingly high candle, 22 parts of tall rattlesnake plantain herbs, 16 parts of ventilago leiocarpas, 29 parts of reticulate millettias, 33 parts of chicken bone bavins, 15 parts of false nettleleaf pepper herbs, glabrousleaf pittosporum root21 parts, 22 parts of delavay violet roots, 15 parts of sinomenium acutums, 13 parts of cassia twig, 17 parts, river cassia bark, 14 parts, Chinese elm stem, 26 parts, Poria cocos, blood aspidistra 17Part, 17 parts of 32 parts of glossy ganodermas and wilsoniis.
6. according to the arbitrary described Chinese medicine of claim 1-5, it is characterized in that the parts by weight of each raw medicinal material in described Chinese medicineThan being: 24 parts of the Radixs Astragali, 18 parts of chrysanthemum ginsengs, 21 parts of lichee, 15 parts of broadleaf sedge roots, 21 parts of densehead mountainash fruits, 16 parts of sieve beans, common embelia fruit 15Part, 19 parts of Ligusticum wallichiis, 17 parts of the root of herbaceous peonys, 11 parts of saline cistanches, 25 parts of Radix Angelicae Sinensis, 6 parts of yunnan craibiodendron leafs, 30 parts of prepared rhizomes of rehmannia, 18 parts of cutworms, dried scallop 16Part, 14 parts, exceedingly high candle, 19 parts of tall rattlesnake plantain herbs, 19 parts of ventilago leiocarpas, 32 parts of reticulate millettias, 28 parts of chicken bone bavins, 17 parts of false nettleleaf pepper herbs, glabrousleaf pittosporum root16 parts, 20 parts of delavay violet roots, 13 parts of sinomenium acutums, 11 parts of cassia twig, 15 parts, river cassia bark, 17 parts, Chinese elm stem, 30 parts, Poria cocos, blood aspidistra 15Part, 21 parts of 28 parts of glossy ganodermas and wilsoniis.
7. according to the arbitrary described Chinese medicine of claim 1-6, it is characterized in that, when the formulation of described Chinese medicine is decoction, its preparationMethod comprises the following steps:
Step 1: described raw medicinal material is mixed and puts into purple casserole, add clear water, soaked medicinal material upper surface 2-5cm to clear water,Soak 3-10 hour;
Step 2: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 30-50 minute, filter, obtain filtrate a, standbyWith;
Step 3: the residue dregs of a decoction are added to clear water again, soaked medicinal material upper surface 2-3cm to clear water, soak 3-10 hour;
Step 4: purple casserole is placed in to fire upper, after intense fire boils, uses slow fire instead and decoct slowly 25-35 minute, filter, obtain filtrate b, willFiltrate a and filtrate b mix.
8. according to the arbitrary described Chinese medicine of claim 1-7, it is characterized in that, when the formulation of described Chinese medicine is lotion, its preparationMethod comprises the following steps:
The first step, mixes described raw medicinal material in proportion, puts into micronizer and is ground into 0.1~10 μ m volume averaging grainThe micron particles in footpath and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μ m volume average particle size, described mixingThe powder rate that obtains of powder is at least 95%;
Second step, adds the determining alcohol with respect to 3~5 times of the quality of described mixed powder in the first step in the mixed powder obtainingBe 85%~95% ethanol, stirring and dissolving obtains ethanolic solution, and ethanolic solution is left standstill to 24~36 under the condition of 5 DEG C~10 DEG CHour, adopt the speed slowly diacolation of percolation with 1~2ml per minute, collect percolate, concentrate and be dried, and put at thisIn micronizer, pulverize 40~60 minutes, the micron particles and the particle diameter that obtain 0.1~10 μ m volume average particle size are less than 0.1The mixed powder of the nano-scale particle composition of μ m volume average particle size, the powder rate that obtains of described mixed powder is at least 95%;
The 3rd step, adds deionized water with respect to mixed powder quality 2~3 times in the mixed powder obtaining at second step, decoctsBoil 2~4 hours, filter, obtain lotion.
9. according to the arbitrary described Chinese medicine of claim 1-8, it is characterized in that, when the formulation of described Chinese medicine is capsule, its systemPreparation Method comprises the following steps:
The first step by the Radix Astragali, chrysanthemum ginseng, lichee, broadleaf sedge root, densehead mountainash fruit, sieve bean, common embelia fruit, Ligusticum wallichii and the root of herbaceous peony in described ratioMix, add with respect to the water extraction of 4~6 times, mixture and get volatile oil, by obtain volatile oil beta-cyclodextrin inclusion compound, volatile oil andThe mass ratio of beta-schardinger dextrin-is 1: 3~6, stirs 60 minutes~90 minutes, and 30 DEG C~50 DEG C of temperature, obtain volatile oil clathrate compound,For subsequent use; The clear cream that while separately aqueous extract being concentrated into 60 DEG C, relative density is 1.15~1.17;
Second step, by saline cistanche, Radix Angelicae Sinensis, yunnan craibiodendron leaf, prepared rhizome of rehmannia, cutworm, dried scallop, exceedingly high candle, tall rattlesnake plantain herb, ventilago leiocarpa and chicken bloodRattan mixes in described ratio, and the alcohol reflux that to add with respect to 5~8 times, mixture amount determining alcohols be 75%~90% extracts 3~5 times,Each 2~3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, and while being concentrated into 60 DEG C, relative density is 1.20~1.22Clear cream, for subsequent use;
The 3rd step, will remain described raw medicinal material and mix in described ratio, add with respect to 8~10 times of water gagings of mixture, boil 6~8 hours, filter the clear cream that while being concentrated into 60 DEG C, relative density is 1.28~1.30;
The 4th step, mixes the clear cream of the first step, second step, the 3rd step, and 60 DEG C~70 DEG C reduced vacuum are dry, and powder gets dry extract;
The 5th step, fully mixes dried cream powder described in volatile oil clathrate compound described in the first step and the 4th step, add subsequently with respect toThe mixture of volatile oil clathrate compound and dried cream powder described in 100 weight portions, 5~7 weight portion sodium carboxymethyl starches, 5~50 weight portionsStarch mixes, and adding 150~200 weight portion determining alcohols is 80%~90% alcohol granulation, dry, and whole grain, adds phase subsequentlyFor the mixture of volatile oil clathrate compound described in 100 weight portions and dried cream powder, 3~5 weight portion dolomols, then pack gelatin intoIn capsule.
CN201610057663.6A 2016-01-28 2016-01-28 Traditional Chinese medicine for treating blood deficiency type postpartum pain of body and preparing method thereof Withdrawn CN105596754A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103816394A (en) * 2014-03-18 2014-05-28 孙丽 Traditional Chinese medicine for treating postpartum pain of body caused by blood deficiency symptom
CN104127831A (en) * 2014-08-22 2014-11-05 张梅 Traditional Chinese medicine for treating pantalgia after childbirth caused by exogenous pathogen and preparation method thereof
CN104352727A (en) * 2014-10-30 2015-02-18 张立 Traditional Chinese medicine composition for curing postpartum pain of body and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103816394A (en) * 2014-03-18 2014-05-28 孙丽 Traditional Chinese medicine for treating postpartum pain of body caused by blood deficiency symptom
CN104127831A (en) * 2014-08-22 2014-11-05 张梅 Traditional Chinese medicine for treating pantalgia after childbirth caused by exogenous pathogen and preparation method thereof
CN104352727A (en) * 2014-10-30 2015-02-18 张立 Traditional Chinese medicine composition for curing postpartum pain of body and preparation method thereof

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