CN105582486A - Pain-relieving traditional Chinese medicine composition containing folium artemisiae argyi - Google Patents

Pain-relieving traditional Chinese medicine composition containing folium artemisiae argyi Download PDF

Info

Publication number
CN105582486A
CN105582486A CN201610147818.5A CN201610147818A CN105582486A CN 105582486 A CN105582486 A CN 105582486A CN 201610147818 A CN201610147818 A CN 201610147818A CN 105582486 A CN105582486 A CN 105582486A
Authority
CN
China
Prior art keywords
parts
chinese medicine
medicine composition
radix
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201610147818.5A
Other languages
Chinese (zh)
Inventor
刘学键
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yantai Huawen Xinxin Pharmaceutical Co Ltd
Original Assignee
Yantai Huawen Xinxin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yantai Huawen Xinxin Pharmaceutical Co Ltd filed Critical Yantai Huawen Xinxin Pharmaceutical Co Ltd
Priority to CN201610193550.9A priority Critical patent/CN105688086A/en
Priority to CN201610147818.5A priority patent/CN105582486A/en
Publication of CN105582486A publication Critical patent/CN105582486A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282—Artemisia, e.g. wormwood or sagebrush
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/285—Aucklandia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/902—Sparganiaceae (Bur-reed family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9062—Alpinia, e.g. red ginger or galangal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Dermatology (AREA)

Abstract

The invention discloses a pain-relieving traditional Chinese medicine composition containing folium artemisiae argyi, and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine is prepared from folium artemisiae argyi, roots of saussurea ussuriensis Maxim., leaves of clematis filamentosa Dunn, rhizoma chuanxiong, rhizoma curcumae, rhizoma sparganii, radix salviae miltiorrhizae, rhizoma galangae, rhizoma corydalis, radix aucklandiae, longstamen onion bulb, lychee seeds and liquorice roots. The traditional Chinese medicine composition has the advantages of being fast in effect taking, good in effect, capable of treating both symptoms and root causes and combining regulation with treatment and the like in the aspect of pain relief and has a significant pain relieving effect particularly on pain caused by blood stasis or cold and damp invasion; besides, the preparation technology of the traditional Chinese medicine composition is simple and convenient and easy to implement, and the preparation is stable in medicinal effect, good in universality and easy to apply and popularize.

Description

A kind of Chinese medicine composition with pain relieving effect that contains tarragon
Technical field
The invention belongs to technical field of traditional Chinese medicines, relate to a kind of Chinese medicine composition with pain relieving effect that contains tarragon.
Background technology
In life, fall to beat and collide with unavoidablely, easily cause body local subcutaneous soft tissue bruise, tear, hemorrhage or ooze out,Thereby cause injury pain and swelling hemorrhage, it is stagnant that its cause of disease of tcm diagnosis is that extravasated blood is stopped up, the blood resistance of holding one's breath. Doctor trained in Western medicine adopts conventionally clinicallyAnti-inflammatory, analgesic are treated, but these medicines cure the symptoms, not the disease, hemostasis in a short time, analgesic effect is obvious, but drug effectDuration is short and have certain side effect, and Reusability easily forms pharmacological dependence. Chinese traditional treatment disease according to treating both principal and secondary aspect of disease,The advantages such as medical treatment combination, drug side-effect is low, has significant advantage in certificate aspect treatment disease. Exterior-applied formulation can direct effectIn affected part, avoid gastrointestinal tract barrier, damage from basic treatment traumatic injury, local pain caused by ecchymoma, muscle tendon soft tissue targetedlyInjure the diseases such as osteoarthropathy.
Chinese patent application 201110455696.3 discloses a kind of traditional Chinese medicinal composition for blood circulation invigorating, by following weight portionBulk drug composition: cultivated land 28-32 part, reticulate millettia 12-18 part, Radix Angelicae Sinensis 8-12 part, Huaihe River ox sunset 8-12 part, Radix Glycyrrhizae 4-6 part, longspur epimedium8-12 part, teasel root 12-18 part, frankincense 4-6 part, Psoralea corylifolia 8-12 part, Herba Cistanches 8-12 part, profound Hu 8-12 part, bark of eucommia 12-18Part, radix pseudostellariae 18-22 part, borneol 3-5 part, ground bettle 4-12 part; This Chinese medicine composition has nourshing blood and promoting blood circulation, the strong muscle of kidney tonifying itEffect, is used for the treatment of caused by liver and kidney deficiency, and the disease such as chronic lumbar strain is evident in efficacy due to deficient qi and blood, but stops up stagnantly for extravasated blood, and blood closesThe pain that vapour lock causes, analgesic effect is not good.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition with pain relieving effect that contains tarragon, andUse modern pharmaceutical technology that this Chinese medicine is made to the required finished product preparation of modern clinic.
In order to solve the problems of the technologies described above, inventor is according to the feature of modern pharmaceutical technology and tcm clinical practice warp for many yearsTest, with and at years of researches aspect pain relieving, meticulously compatibility medicinal material, is adjusted, is increased and decreased the deal of bulk drug repeatedly by practiceAnd kind, finally invent a brand-new Chinese prescription, in weight portion, the raw material of this Chinese prescription consists of:
Tarragon 23-30 part, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 21-29 part, sweet akebi 17-25 part, Ligusticum wallichii 18-28 part, curcuma zedoary 16-21 part, Rhizoma Sparganii 16-21Part, red sage root 10-15 part, galangal 14-18 part, corydalis tuber 11-17 part, banksia rose 10-15 part, Longstamen Onion Bulb 12-18 part, semen litchi 13-19Part, Radix Glycyrrhizae 6-13 part.
From optimizing significant 3 the raw material proportionings of result for the treatment of in prescription quantitative range be:
Proportioning 1: 23 parts of tarragons, 21 parts of Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae)s, 17 parts of sweet akebis, 18 parts of Ligusticum wallichiis, 16 parts of curcuma zedoarys, 16 parts of Rhizoma Sparganiis, 10 parts of the reds sage root,14 parts of galangals, 11 parts of corydalis tubers, 10 parts of the banksia rose, 12 parts of Longstamen Onion Bulbs, 13 parts of semen litchis, 6 parts, Radix Glycyrrhizae.
Proportioning 2: 30 parts of tarragons, 29 parts of Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae)s, 25 parts of sweet akebis, 28 parts of Ligusticum wallichiis, 21 parts of curcuma zedoarys, 21 parts of Rhizoma Sparganiis, the red sage root15 parts, 18 parts of galangals, 17 parts of corydalis tubers, 15 parts of the banksia rose, 18 parts of Longstamen Onion Bulbs, 19 parts of semen litchis, 13 parts, Radix Glycyrrhizae.
Proportioning 3: 27 parts of tarragons, 25 parts of Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae)s, 21 parts of sweet akebis, 23 parts of Ligusticum wallichiis, 19 parts of curcuma zedoarys, 19 parts of Rhizoma Sparganiis, the red sage root12 parts, 15 parts of galangals, 13 parts of corydalis tubers, 14 parts of the banksia rose, 15 parts of Longstamen Onion Bulbs, 14 parts of semen litchis, 9 parts, Radix Glycyrrhizae.
Accordingly, the present invention also provides the preparation side of the described Chinese medicine composition with pain relieving effect that contains tarragonMethod, comprises the following steps:
By tarragon, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae), sweet akebi, Ligusticum wallichii, curcuma zedoary, Rhizoma Sparganii, the red sage root, galangal, corydalis tuber, the banksia rose, Longstamen Onion Bulb, semen litchi, sweetGrass, pulverizes respectively, crosses 20 mesh sieves, adds the distilled water of 7-11 times of medicinal material gross weight after mixing, soaks 6-12 hour, decoct 2-3 time,Each 2-5 hour, filters, and merging filtrate is also concentrated into the concentrate that 55-60 DEG C of relative density is 1.20-1.25, i.e. get Ben FaBright Chinese medicine composition.
Utilize modern Chinese herbal medicine preparation common process Chinese medicine composition of the present invention can be made to clinical acceptable exterior-applied formulation,For example ointment, cream, spray or liniment.
The character feature of Chinese medicine composition of the present invention Chinese medicine used:
Tarragon: the dry leaf of this product feverfew Chinese mugwort. Taste is pungent, bitter, warm in nature; Return liver,spleen,kidney warp; Eliminating cold to stop pain, warming channel for arresting bleeding.
Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae): this product is that composite family Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) is used as medicine with root. Taste is pungent, warm in nature; The thoughts of returning home, spleen, kidney channel; Dispelling cold, the loose stasis of blood, townBitterly.
Sweet akebi: this product is the leaf of the sweet akebi of Ranunculaceae. Taste is sweet, slightly cool in nature, cold nature; Return liver, the heart channel of Hang-Shaoyin; Clearing away the liver-fire; RatherThe mind; Hypotensive; Remove obstruction in channels to relieve pain.
Ligusticum wallichii: this product is the dry rhizome of samphire Ligusticum wallichii; Taste is pungent, warm in nature; Return liver, courage, pericardium channel; The row of invigorating blood circulationGas, wind-expelling pain-stopping.
Curcuma zedoary: this product is the dry rhizome of zingiberaceous plant zedoary, Guangxi zedoary or RADIX CURCUMAE; Taste is pungent, bitter, warm in nature; ReturnLiver, the spleen channel; Blood is broken in promoting the circulation of qi, and long-pending pain relieving disappears.
Rhizoma Sparganii: this product is that this product is the dry tuber of Sparganiaceae plant rhizoma scirpi. Bitter, pungent, property is flat; Return liver, the spleen channel;Broken blood gas, long-pending pain relieving disappears.
The red sage root: this product is the dry root and rhizome of the labiate red sage root; Bitter, cold nature; The thoughts of returning home, Liver Channel; The stasis of blood of dispelling onlyBitterly, activating blood to promote menstruation, relieving restlessness clears away heart-fire.
Galangal: this product is the dry rhizome of zingiberaceous plant galangal. Taste is pungent, hot in nature; Return spleen, stomach warp; Warming stomach for dispelling cold, disappearsFood pain relieving.
Corydalis tuber: the dry tuber that this product is papaveraceae plant corydalis. Taste is arduous, warm in nature; Return liver, the spleen channel; Promoting blood circulation and removing blood stasis,Promoting qi circulation and relieving pain.
The banksia rose: this product is the dry root of the feverfew banksia rose. Taste is pungent, bitter, warm in nature; Return spleen, stomach, large intestine, three warmers, gallbladder channel;Promoting qi circulation and relieving pain, reinforcing spleen to promote digestion.
Longstamen Onion Bulb: this product is the dry bulb of liliaceous plant Allium macrostemon or Chinese onion. Bitter, pungent, warm in nature; Return stomach, lung, large intestineWarp; Activate yang and remove abstruction, promoting the circulation of qi is led stagnant.
Semen litchi: this product is the dry mature seed of sapindaceous plant lichee. Sweet, the micro-hardship of taste, warm in nature; Return liver, kidney channel;Promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, glycyrrhiza inflate bat or glycyrrhiza glabra. Taste is sweet, and property is flat; The thoughts of returning home, lung,Spleen, stomach warp; Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.
The prescription analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention is taking tarragon, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) as monarch drug in a prescription, eliminating cold to stop pain, warming channel for arresting bleeding; With sweet akebi, Ligusticum wallichii, curcuma zedoaryWith Rhizoma Sparganii be ministerial drug, remove obstruction in channels to relieve pain, promoting blood circulation and removing obstruction in channels, long-pending pain relieving disappears; With the red sage root, galangal, corydalis tuber, the banksia rose, Longstamen Onion Bulb and semen litchiFor adjutant, softening and resolving hard mass pain relieving, regulate channels and activate collateral; With Radix Glycyrrhizae, for making medicine, coordinating the drug actions of a prescription, makes all medicine collocation, and synergy, plays altogetherEffect of promoting blood circulation and removing obstruction in channels, the dismission of dispelling rheumatism, subside a swelling, the pain relieving of inducing sweat, has significant analgesic effect.
Pharmacodynamic experiment shows that Chinese medicine composition of the present invention, aspect pain relieving, anti-inflammatory and eliminating stasis to resolve swelling, has significant treatmentEffect. The swelling pain causing for traumatic injury, local pain caused by ecchymoma, muscle tendon soft tissue injury and osteoarthropathy belongs to blood stasis resistanceStagnant, cold-damp invading in the interior,inward invasion of cold-damp person have instant effect, effective, treat both principal and secondary aspect of disease, recuperate under medical treatment in conjunction with, be difficult for the technical advantage such as recurrence, especially forCureless pain relieving has result for the treatment of significantly, and Chinese medicinal composition preparation efficacy stability of the present invention, universality be good,Be easy to apply.
Therefore, the present invention also claimed above-mentioned Chinese medicine composition in the application of preparing in analgesic drug product.
Detailed description of the invention
Embodiment 1
Embodiment 1 Chinese medicine composition is prepared from by the raw material of following parts by weight:
23 parts of tarragons, 21 parts of Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae)s, 17 parts of sweet akebis, 18 parts of Ligusticum wallichiis, 16 parts of curcuma zedoarys, 16 parts of Rhizoma Sparganiis, 10 parts of the reds sage root, galangal6 parts, 14 parts, 11 parts of corydalis tubers, 10 parts of the banksia rose, 12 parts of Longstamen Onion Bulbs, 13 parts of semen litchis and Radix Glycyrrhizae.
Preparation method:
(1) by tarragon, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae), sweet akebi, Ligusticum wallichii, curcuma zedoary, Rhizoma Sparganii, the red sage root, galangal, corydalis tuber, the banksia rose, Longstamen Onion Bulb, semen litchi,Radix Glycyrrhizae, pulverizes respectively, crosses 20 mesh sieves, adds the distilled water of 9 times of medicinal material gross weights after mixing, soaks 6 hours, decocts each 32 timesHour, filtering, merging filtrate is also concentrated into the concentrate that 60 DEG C of relative densities are 1.20, obtains Chinese medicine composition of the present invention;
(2) add auxiliary material, Chinese medicine composition of the present invention is made to ointment, amount to crude drug content 0.55 crude drug/g ointment.
Embodiment 2
Embodiment 2 Chinese medicine compositions are prepared from by the raw material of following parts by weight:
30 parts of tarragons, 29 parts of Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae)s, 25 parts of sweet akebis, 28 parts of Ligusticum wallichiis, 21 parts of curcuma zedoarys, 21 parts of Rhizoma Sparganiis, 15 parts of the reds sage root, galangal13 parts, 18 parts, 17 parts of corydalis tubers, 15 parts of the banksia rose, 18 parts of Longstamen Onion Bulbs, 19 parts of semen litchis and Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3
Embodiment 3 Chinese medicine compositions are prepared from by the raw material of following parts by weight:
27 parts of tarragons, 25 parts of Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae)s, 21 parts of sweet akebis, 23 parts of Ligusticum wallichiis, 19 parts of curcuma zedoarys, 19 parts of Rhizoma Sparganiis, 12 parts of the reds sage root, galangal9 parts, 15 parts, 13 parts of corydalis tubers, 14 parts of the banksia rose, 15 parts of Longstamen Onion Bulbs, 14 parts of semen litchis and Radix Glycyrrhizae.
Preparation method is with embodiment 1.
The pharmacodynamic experiment of Chinese medicine composition of the present invention
1, test drug: the embodiment of the present invention prepared 0.55 crude drug/g ointment. Positive control drug is bonesetting liquid (traditional Chinese medicines standardWord Z45021659, Guangxi Yulin Pharmaceutical Group Co., Ltd.), dexamethasone (the accurate word H20060241 of traditional Chinese medicines, gold day pharmacy(China) Co., Ltd).
2, test animal used: regular grade NIH mouse, body weight 24g ± 3g.
3, test method
(1) analgesic experiment
Get 80 of healthy mices, male, be divided into 8 groups, 10 every group, i.e. the embodiment of the present invention 2 Chinese traditional medicine composition object height agentAmount group, middle dosage group and low dose group, embodiment 3 Chinese medicine composition high dose group, middle dosage group and low dose group, positive controlGroup, model control group. Drug study group Experimental agents of the present invention is the ointment that the embodiment of the present invention 2, embodiment 3 make, and givesPharmaceutical quantities is high dose group (4.2g/kg), middle dosage group (2.8g/kg) and low dose group (1.4g/kg), and positive control drug is for justBone water (the accurate word Z45021659 of traditional Chinese medicines, Guangxi Yulin Pharmaceutical Group Co., Ltd.), dosage is 4.2g/kg, modelControl group is coated with the blank matrix of the embodiment of the present invention 1 ointment of equivalent, and administration is de-by mouse belly with 8% vulcanized sodium the previous dayHair, is according to dosage coated with corresponding medicine 1 time every day, and continuous three days, fasting 12h before the administration of mouse last, after last administration 1h, each groupMouse peritoneal is injected 0.7% acetic acid normal saline solution 0.2ml/ only, the writhing number of times of each mouse in observed and recorded 20 minutes, thanRespectively organize difference. The results are shown in Table 1.
The impact (n=10) of table 1 acetic acid induced mice pain (）
Note: with model control group comparison, drug test group * P < 0.05, * * P < 0.01, with positive controls comparison, in the present inventionDrug composition drug test group #P < 0.05, ##P < 0.01.
Result demonstration, compared with model control group, drug study group all can significantly reduce mice pain twisting number of times, explanationDrug study group all has significant analgesic effect to mouse acetic acid is pain caused, and the middle and high dosage of Chinese medicine composition of the present inventionThe relieving pain of group is better than positive controls.
(2) impact of Chinese medicine composition Dichlorodiphenyl Acetate induced mice of the present invention abdominal cavity capillary permeability experiment
Get 80 of NIH mouse, male and female half and half, are divided into 8 groups at random, and 10 every group, i.e. the embodiment of the present invention 2 Chinese traditional medicine composition object height agentAmount group, middle dosage group and low dose group, embodiment 3 Chinese medicine composition high dose group, middle dosage group and low dose group, positive controlGroup, model control group. Drug study group Experimental agents of the present invention is the ointment that the embodiment of the present invention 2, embodiment 3 make, and givesPharmaceutical quantities is high dose group (4.2g/kg), middle dosage group (2.8g/kg) and low dose group (1.4g/kg), and positive control drug is for multipleSide's dexamethasone gel (the accurate word H20060241 of traditional Chinese medicines, Golden Sun Pharmaceutical (China) Co., Ltd.), dosage is 1.4g/kg,Model control group is coated with the blank matrix of the embodiment of the present invention 2 ointments of equivalent, administration the previous day with 8% vulcanized sodium by mouse abdomenPortion's depilation, is according to dosage coated with corresponding medicine 1 time every day, and continuous three days, fasting 12h before the administration of mouse last, after last administration 1h,Each caudal vein is injected 2% Evans blue physiological saline 0.1ml/10g, lumbar injection 0.7% acetic acid physiological saline immediately after injectionSolution 0.2ml/ only, puts to death mouse after 20 minutes, cuts abdominal cavity open, with 5ml normal saline flushing several, collects washing lotion, centrifugal, getsSupernatant is surveyed OD value at spectrophotometer 590nm place, more each group difference, the results are shown in Table 2.
The impact (n=10) of table 2 Chinese medicine composition Dichlorodiphenyl Acetate induced mice of the present invention abdominal cavity capillary permeability (）
Note: with model control group comparison, drug test group * * P < 0.01.
Result demonstration, it is penetrating that the each dosage group of Chinese medicine composition of the present invention all can significantly suppress acetic acid induced mice capillaryProperty increases, and its effect is suitable with positive control drug Compound Dexamethasone, illustrates that Chinese medicine composition of the present invention has significant anti-inflammatoryEffect.
(3) eliminating stasis to resolve swelling test
Get 80 of NIH mouse, male and female half and half, are divided into 8 groups at random, and 10 every group, i.e. the embodiment of the present invention 2 Chinese traditional medicine composition object height agentAmount group, middle dosage group and low dose group, embodiment 3 Chinese medicine composition high dose group, middle dosage group and low dose group, positive controlGroup, model control group. Drug study group Experimental agents of the present invention is the ointment that the embodiment of the present invention 2, embodiment 3 make, and givesPharmaceutical quantities is high dose group (4.2g/kg), middle dosage group (2.8g/kg) and low dose group (1.4g/kg), and positive drug is bonesetting liquid(traditional Chinese medicines Zhun Zi Z45021659 Guangxi Yulin Pharmaceutical Group Co., Ltd.), dosage is 4.2g/kg, model control groupBe coated with the blank matrix of the embodiment of the present invention 3 ointments of equivalent. The modeling as follows of each group mouse: with 8% vulcanized sodium to mouseBack depilation 2cm × 3cm, within 1 day, posterior orbit is got blood 0.4ml, with 50u/ml heparin-saline 0.1ml anti-freezing, the hypodermic injection back of the bodyPortion's depilation place, forms subcutaneous blood cake, after 4h, measure blood cake area as administration before blood cake area. Each group mouse is according to dosage by correspondingMedicine is applied to blood cake place, every day twice, and measure blood cake area every day, until blood cake disappears. Relatively first day, second day, theThe blood cake area of three days, the results are shown in Table 3.
The eliminating stasis to resolve swelling result of the test (n=10) of table 3 Chinese medicine composition of the present invention (）
Note: with model control group comparison, drug test group * P < 0.05, * * P < 0.01, with positive controls comparison, in the present inventionDrug composition drug test group #P < 0.05.
The demonstration of mouse eliminating stasis to resolve swelling experimental result, the each dosage group of Chinese medicine composition of the present invention all can significantly reduce blood cake areaAnd reduce blood cake extinction time, and the effect of high dose group eliminating stasis to resolve swelling is significantly better than positive controls.
More than experiment shows, the present invention has significant analgesic activity, also has significant anti-inflammatory simultaneously and improves micro-followingThe effect of ring, eliminating stasis to resolve swelling is evident in efficacy.

Claims (7)

1. a Chinese medicine composition with pain relieving effect that contains tarragon, is characterized in that, described Chinese medicine composition by belowThe raw material of parts by weight is prepared from: tarragon 23-30 part, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 21-29 part, sweet akebi 17-25 part, Ligusticum wallichii 18-28 part, cowherbArt 16-21 part, Rhizoma Sparganii 16-21 part, red sage root 10-15 part, galangal 14-18 part, corydalis tuber 11-17 part, banksia rose 10-15 part, Longstamen Onion Bulb12-18 part, semen litchi 13-19 part and Radix Glycyrrhizae 6-13 part.
2. the Chinese medicine composition with pain relieving effect that contains tarragon according to claim 1, is characterized in that, described inDrug composition is prepared from by the raw material of following parts by weight: 23 parts of tarragons, 21 parts of Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae)s, 17 parts of sweet akebis, 18 parts of Ligusticum wallichiis,16 parts of curcuma zedoarys, 16 parts of Rhizoma Sparganiis, 10 parts of the reds sage root, 14 parts of galangals, 11 parts of corydalis tubers, 10 parts of the banksia rose, 12 parts of Longstamen Onion Bulbs, 13 parts of semen litchis and6 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition with pain relieving effect that contains tarragon according to claim 1, is characterized in that, described inDrug composition is prepared from by the raw material of following parts by weight: 30 parts of tarragons, 29 parts of Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae)s, 25 parts of sweet akebis, 28 parts of Ligusticum wallichiis,21 parts of curcuma zedoarys, 21 parts of Rhizoma Sparganiis, 15 parts of the reds sage root, 18 parts of galangals, 17 parts of corydalis tubers, 15 parts of the banksia rose, 18 parts of Longstamen Onion Bulbs, 19 parts of semen litchis and13 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition with pain relieving effect that contains tarragon according to claim 1, is characterized in that, described inDrug composition is prepared from by the raw material of following parts by weight: 27 parts of tarragons, 25 parts of Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae)s, 21 parts of sweet akebis, 23 parts of Ligusticum wallichiis,19 parts of curcuma zedoarys, 19 parts of Rhizoma Sparganiis, 12 parts of the reds sage root, 15 parts of galangals, 13 parts of corydalis tubers, 14 parts of the banksia rose, 15 parts of Longstamen Onion Bulbs, 14 parts of semen litchis and9 parts, Radix Glycyrrhizae.
5. according to the Chinese medicine composition with pain relieving effect that contains tarragon described in claim 1-4 any one, its feature existsIn, the preparation method of described Chinese medicine composition comprises the following steps: by tarragon, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae), sweet akebi, Ligusticum wallichii, curcuma zedoary, Rhizoma Sparganii,The red sage root, galangal, corydalis tuber, the banksia rose, Longstamen Onion Bulb, semen litchi, Radix Glycyrrhizae, pulverize respectively, crosses 20 mesh sieves, adds 7-11 times of medicinal material total after mixingThe distilled water of weight, soaks 6-12 hour, decocts 2-3 time, and each 2-5 hour, filters, and merging filtrate is also concentrated into 55-60 DEG CRelative density is the concentrate of 1.20-1.25, obtains Chinese medicine composition.
6. according to the arbitrary described Chinese medicine composition with pain relieving effect that contains tarragon of claim 1-4, it is characterized in that:The formulation of described Chinese traditional medicine composition is exterior-applied formulation.
7. the Chinese medicine composition with pain relieving effect that contains tarragon according to claim 6, is characterized in that: in describedThe exterior-applied formulation of drug composition is ointment, cream, spray or liniment.
CN201610147818.5A 2016-03-16 2016-03-16 Pain-relieving traditional Chinese medicine composition containing folium artemisiae argyi Withdrawn CN105582486A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201610193550.9A CN105688086A (en) 2016-03-16 2016-03-16 Application of traditional Chinese medicine composition in preparation of analgesic medicine
CN201610147818.5A CN105582486A (en) 2016-03-16 2016-03-16 Pain-relieving traditional Chinese medicine composition containing folium artemisiae argyi

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610147818.5A CN105582486A (en) 2016-03-16 2016-03-16 Pain-relieving traditional Chinese medicine composition containing folium artemisiae argyi

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610193550.9A Division CN105688086A (en) 2016-03-16 2016-03-16 Application of traditional Chinese medicine composition in preparation of analgesic medicine

Publications (1)

Publication Number Publication Date
CN105582486A true CN105582486A (en) 2016-05-18

Family

ID=55922635

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201610147818.5A Withdrawn CN105582486A (en) 2016-03-16 2016-03-16 Pain-relieving traditional Chinese medicine composition containing folium artemisiae argyi
CN201610193550.9A Withdrawn CN105688086A (en) 2016-03-16 2016-03-16 Application of traditional Chinese medicine composition in preparation of analgesic medicine

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201610193550.9A Withdrawn CN105688086A (en) 2016-03-16 2016-03-16 Application of traditional Chinese medicine composition in preparation of analgesic medicine

Country Status (1)

Country Link
CN (2) CN105582486A (en)

Also Published As

Publication number Publication date
CN105688086A (en) 2016-06-22

Similar Documents

Publication Publication Date Title
CN102772712A (en) Traditional Chinese medicine composition for treating heat-toxicity, flourishing and blood stasis type diabetic foot
CN104225507A (en) Chinese medicine for treating limb paralysis and pain caused by cerebral hemorrhage
CN105412621A (en) Method for preparing pharmaceutical composition for treating hemorrhoids
CN105343578A (en) Medicine composition for treating haemorrhoids
CN105582486A (en) Pain-relieving traditional Chinese medicine composition containing folium artemisiae argyi
CN105288499A (en) Traditional Chinese medicine composition containing folium artemisiae argyi and having pain relieving effect
CN103520684A (en) Traditional Chinese medicine compound for reducing blood sugar
CN105833181A (en) Traditional Chinese medicine composition for treating chronic pelvic inflammatory disease and preparing method thereof
CN101401881B (en) Chinese medicinal composition for treating poison produced by venomous insects
CN105434808A (en) Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof
CN104887866A (en) Traditional Chinese medicine for treating gout
CN105125714A (en) Traditional Chinese medicine preparation for treating chemotherapeutic phlebitis and preparing method thereof
CN105288500A (en) Method for preparing folium artemisiae argyi-contained traditional Chinese medicine composition having analgesic efficacy
CN105168774A (en) Traditional Chinese medicine preparation for treating scapulohumeral periarthritis and preparation method thereof
CN116270949A (en) Traditional Chinese medicine composition for reducing hyperuricemia and preparation method thereof
CN116077606A (en) Pharmaceutical composition for treating prostatic hyperplasia, preparation method and application
CN114588233A (en) Composition for treating acute gout
CN113318167A (en) Traditional Chinese medicine composition for treating rheumatoid arthritis
CN110841033A (en) Traditional Chinese medicine health-care waistband for preventing and treating blood deficiency and cold coagulation type dysmenorrhea and preparation method thereof
CN107773728A (en) A kind of Chinese medicinal capsule for being used to treat bradycardia
CN105919961A (en) Preparation method for traditional Chinese medicine for treating Yin-deficiency blood-heat syndrome heel pain and composition thereof
CN108310237A (en) Zhitan Chinese medicine is drunk
CN107789574A (en) A kind of Chinese medicinal capsule for being used to treat deficiency of heart-blood card bradycardia
CN106994140A (en) A kind of Chinese medicine composition and its application method for treating lupus nephritis
CN105663759A (en) Traditional Chinese medicine preparation for treating leucoderma and preparation method thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20160518