Specific embodiment
With reference to preferred embodiment of the invention below detailed description and including embodiment this public affairs can be more easily to understand
Open content.A large amount of term is referred in following description and claims, these terms are defined as following contain
Justice.
" optionally " or " optionally " refer to that subsequently described event or item may or may not occur, and the description
The situation that the situation and event occurred including event does not occur.
Approximate term in specification and claims is used to modify quantity, and it is specific to indicate that the present invention is not limited to this
Quantity further includes the acceptable modified part without will lead to the change of dependency basis this function close with the quantity.Phase
It answers, modifies a numerical value with " about ", " about " etc., mean that the present invention is not limited to the exact numericals.In some examples, approximate
Term likely corresponds to the precision of the equipment of measurement numerical value.In present specification and claims, range limits can be with
Combination and/or exchange, these ranges if not stated otherwise include all subranges contained therebetween.
As used herein term " by ... preparation " it is synonymous with "comprising".Term "comprising" used herein, " comprising ",
" having ", " containing " or its any other deformation, it is intended that cover non-exclusionism includes.For example, the combination comprising listed elements
Object, step, method, product or device are not necessarily limited to those elements, but may include not expressly listed other elements or
Such composition, step, method, product or the intrinsic element of device.
Conjunction " Consists of " excludes any element that do not point out, step or component.If in claim, this
Phrase will make claim closed, so that it is not included the material in addition to the material of those descriptions, but relative normal
Except rule impurity.When being rather than immediately following after theme in the clause that phrase " Consists of " appears in claim main body,
It is only limited to element described in the clause;Other elements are not excluded except the claim as a whole.
Equivalent, concentration or other values or parameter are preferred with range, preferred scope or a series of upper limit preferred values and lower limit
When being worth the Range Representation limited, this should be understood as specifically disclosing by under any range limit or preferred value and any range
Any pairing of limit or preferred value is formed by all ranges, regardless of whether the range separately discloses.For example, when disclosing
When range " 1 to 5 ", described range should be interpreted as including range " 1 to 4 ", " 1 to 3 ", " 1-2 ", " 1-2 and 4-5 ", " 1-
3 and 5 " etc..When numberical range is described herein, unless otherwise stated, otherwise the range be intended to include its end value and
All integers and score within the scope of this.
In addition, indefinite article "an" before element of the present invention or component and "one" quantitative requirement to element or component
(i.e. frequency of occurrence) unrestriction.Therefore "one" or "an" should be read as including one or at least one, and odd number
The element or component of form also include plural form, unless the obvious purport of the quantity refers to singular.
High resolution transmission electron microscopy (TEM) uses Japan Electronics JEM-2000, and electron gun is lanthanum hexaboride, midpoint
Resolution ratio 0.23nm, linear resolution 0.14nm, acceleration voltage 200kV erect spot size 1.0-25nm.
Field emission scanning electron microscope is Hitachi S-4800, and electron gun is cold field emission electron source, and acceleration voltage is
0.5-30kV。
It when preparing sample, first disperses sample ultrasonic in easy volatile solvent, such as ethyl alcohol.Carbon support film is put in completely
Filter paper on, drip the solution containing sample with dropper, make to fall on carbon film under it.After solvent volatilizees completely, put
Enter in Electronic Speculum and observes.
Hereinafter, being illustrated to the measuring method of average molecular weight specified in the present invention.
Average molecular weight specified in the present invention is the molecular weight calculated by the inherent viscosity of sample.In the present invention, use
Inherent viscosity is found out by kinematic viscosity, the method which is scaled molecular weight, to find out average molecular weight.More specifically
Say that in the method, the determination of ubbelohde viscometer kinematic viscosity that use illustrates below finds out characteristic by the value of the kinematic viscosity in ground
The inherent viscosity is scaled average molecular weight by viscosity.
Generally, in order to find out the inherent viscosity of sample, firstly, multiple sample solutions are prepared, by the examination of Ubbelohde viscometer
Material solution flow down number of seconds and solvent flow down number of seconds, be based on following formula (1) and formula (2), calculating specific viscosity and reduced viscosity.
Formula (1)
Formula (2)
Secondly, using obtained reduced viscosity as the longitudinal axis, the sample concentration with dried object conversion is cross for each sample solution
Axis marks and draws production calibration curve and obtains the inherent viscosity of sample by the way that above-mentioned sample concentration is extrapolated to 0.Sample is hyalomitome
When sour, according to following formula (3), average molecular weight M can be found out by the inherent viscosity of sample.
Formula (3)
Inherent viscosity (dL/g)=k ' Mα
(in above-mentioned formula (3), k '=0.036, α=0.78).
Secondly, the measuring method of the kinematic viscosity of index when finding out above-mentioned average molecular weight for becoming is illustrated.
Above-mentioned kinematic viscosity is able to use Ubbelohde viscometer and is measured.At this point, selecting to flow down number of seconds as 200-1000 seconds
Coefficient Ubbelohde viscometer.In addition, measurement carries out in 30 DEG C of thermostatic water bath so that temperature-resistantization.
It, can by the product of the coefficient for flowing down number of seconds and Ubbelohde viscometer of the aforesaid liquid using determination of ubbelohde viscometer
Find out kinematic viscosity (unit: mm2/s)。
The present invention provides a kind of whitening anti-aging anti-wrinkle women private portion articles, in parts by weight, includes at least with the following group
Point:
Amino acid in the N- acylamino acid is selected from one of neutral amino acid or acidic amino acid, the moisturizing
Composition includes hyaluronic acid, collagen, and the moisture-keeping composition includes aloe, glycerol.
N- acyl amino acid surfactant
The structural formula of the N- acylamino acid are as follows:
R1For the alkyl containing 3-29 carbon atom, R2For hydrogen atom or the substituent group containing 1-20 carbon atom, X1For hydrogen original
One of son, alkali metal, alkaline-earth metal, ammonium, alkanolamine residue, N- alkyltaurate.
R1It can be saturated chain alkyl, including but not limited to propyl, isopropyl, normal-butyl, isobutyl group, sec-butyl, tertiary fourth
Base, n-pentyl, 1- methyl butyl, 2- methyl butyl, 3- methyl butyl, 1- ethyl propyl, 1,1- dimethyl propyl, 1,2- diformazan
Base propyl, 2,2- dimethyl propyl, n-hexyl, 1- methyl amyl, 2- methyl amyl, 3- methyl amyl, 4- methyl amyl, 1- second
Base butyl, 2- ethyl-butyl, 1,1- dimethylbutyl, 1,2- dimethylbutyl, 1,3- dimethylbutyl, 2,2- dimethyl butyrate
Base, 2,3- dimethylbutyl, 3,3- dimethylbutyl, 1,1,2- thmethylpropyl, 1,2,2- thmethylpropyl, n-heptyl, 1-
Methylhexyl, 2- methylhexyl, 3- methylhexyl, 4- methylhexyl, 5- methylhexyl, 1- ethylpentyl, 2- ethylpentyl, 3-
Ethylpentyl, 1,1- dimethyl amyl group, 1,2- dimethyl amyl group, 1,3- dimethyl amyl group, 1,4- dimethyl amyl group, 2,2- diformazan
Base amyl, 2,3- dimethyl amyl group, 2,4- dimethyl amyl group, 3,3- dimethyl amyl group, 3,4- dimethyl amyl group, 4,4- dimethyl
Amyl, 1,1,2- trimethyl butyl, 1,1,3- trimethyl butyl, 1,2,2- trimethyl butyl, 1,2,3- trimethyl butyl, 1,3,
3- trimethyl butyl, 2,2,3- trimethyl butyl, 2,3,3- trimethyl butyl, octyl, nonyl, decyl, undecyl, laurel
Base, tridecyl, myristyl, pentadecyl, palmityl, pearly-lustre aliphatic radical, stearyl, nonadecyl, peanut base, behenyl base,
Haze tallow base, cerul, nonacosyl.
R1It is also possible to saturated cyclic, including but not limited to cyclopenta, cyclohexyl, 2- methylcyclopentyl, 3- methyl ring
Amyl, suberyl, 2- methylcyclohexyl, 3- methylcyclohexyl, 4- methylcyclohexyl, 2- ethylcyclopentyl, 3- ethylcyclopentyl,
Cyclooctyl, 2- methylcycloheptyl, 3- methylcycloheptyl, 4- methylcycloheptyl, 2,2- Dimethylcyclohexyl, 2,3- dimethyleyelohexane
Base, 2,4- Dimethylcyclohexyl, 3,3- Dimethylcyclohexyl, 3,4- Dimethylcyclohexyl, 4,4- Dimethylcyclohexyl.
R1Be also possible to unsaturated alkyl, including but not limited to 2- acrylic, 1- acrylic, 1- cyclobutenyl, 2- cyclobutenyl,
3- cyclobutenyl, 1- methyl-1-propylene base, 1- methyl -2- acrylic, 2- methyl-1-propylene base, 2- methyl -2- acrylic, 1- penta
Alkenyl, 2- pentenyl, 3- pentenyl, 4- pentenyl, 1- methyl-1-cyclobutenyl, 1- methyl-2-butene base, 1- methyl-3- butylene
Base, 2-methyl-1-butene alkenyl, 2- methyl-2-butene base, 2- methyl -3- cyclobutenyl, 3-methyl-1-butene base, 3- methyl -2-
Cyclobutenyl, 3- methyl -3- cyclobutenyl, 1,2- dimethyl -1- acrylic, 1,1- dimethyl -2- acrylic, 1,2- dimethyl -2-
Acrylic, 1- hexenyl, 2- hexenyl, 3- hexenyl, 4- hexenyl, 5- hexenyl, 1- methyl-1-pentene alkenyl, 1- methyl -2-
Pentenyl, 1- methyl-3-pentenyl, 1- methyl -4- pentenyl, 2- methyl-1-pentene alkenyl, 2- methyl -2- pentenyl, 2- first
Base -3- pentenyl, 2- methyl -4- pentenyl, 3- methyl-1-pentene alkenyl, 3- methyl -2- pentenyl, 3- methyl-3-pentenyl,
3- methyl -4- pentenyl, 4-methyl-1-pentene base, 4- methyl -2- pentenyl, 4- methyl-3-pentenyl, 4- methyl -4- amylene
Base, 1- ethyl -1- cyclobutenyl, 1- ethyl -2- cyclobutenyl, 1- ethyl -3- cyclobutenyl, 2- ethyl -1- cyclobutenyl, 2- ethyl -2-
Cyclobutenyl, 2- ethyl -3- cyclobutenyl, 1,1- dimethyl -2- cyclobutenyl, 1,1- dimethyl -3- cyclobutenyl, 1,2- dimethyl -1-
Cyclobutenyl, 1,2- dimethyl -2- cyclobutenyl, 1,2- dimethyl -3- cyclobutenyl, 1,3- dimethyl -1- cyclobutenyl, 1,3- diformazan
Base -2- cyclobutenyl, 1,3- dimethyl -3- cyclobutenyl, 2,2- dimethyl -3- cyclobutenyl, 2,3- dimethyl -1- cyclobutenyl, 2,3-
Dimethyl-2- cyclobutenyl, 2,3- dimethyl-3- cyclobutenyl, 2- methyl-1-cyclopentenyl, 3- methyl-1-cyclopentenyl, 4- first
Base-1- cyclopentenyl, 5- methyl-1-cyclopentenyl, 2- methyl-2- cyclopentenyl, 3- methyl-2- cyclopentenyl, 4- methyl-2-
Cyclopentenyl, 5- methyl -2- cyclopentenyl, 2- methyl -3- cyclopentenyl, 3- methyl -3- cyclopentenyl, 4- methyl -3- ring penta
Alkenyl, 5- methyl -3- cyclopentenyl, 1- cyclohexenyl group, 2- cyclohexenyl group, 3- cyclohexenyl group, α-flax base, stearidonic
Base, two dodecahexaene bases, sub- oil base, is conjugated sub- oil base, γ-flax base, 20 carbon trialkenyls, peanut at eicosapentaenoic base
Apos, oil base, eicosylene base, 20 carbon trialkenyls, mustard base.
As a preferred technical solution of the present invention, the acyl group in the N- acylamino acid is selected from lauroyl, coconut palm
Oleoyl, myristoyl, palmityl, pearly-lustre fatty acyl group, stearyl, isostearoyl base, peanut acyl group, behenyl acyl group,
Haze tallow acyl group, wax acyl group, melissa acyl group, fatty acid distribution of coconut oil acyl group, palm oil fatty acid acyl group, palm kernel fatty acid acyl group,
At least one of tallow fatty acids acyl group and hardening tallow fatty acids acyl group.
R2Can be hydrogen atom, be also possible to hydrocarbyl substituent, including but not limited to methyl, ethyl, propyl, isopropyl,
Normal-butyl, isobutyl group, sec-butyl, tert-butyl, n-pentyl, 1- methyl butyl, 2- methyl butyl, 3- methyl butyl, 1- ethyl third
Base, 1,1- dimethyl propyl, 1,2- dimethyl propyl, 2,2- dimethyl propyl, n-hexyl, 1- methyl amyl, 2- methyl amyl,
3- methyl amyl, 4- methyl amyl, 1- ethyl-butyl, 2- ethyl-butyl, 1,1- dimethylbutyl, 1,2- dimethylbutyl, 1,
3- dimethylbutyl, 2,2- dimethylbutyl, 2,3- dimethylbutyl, 3,3- dimethylbutyl, 1,1,2- thmethylpropyl, 1,
2,2- thmethylpropyl, octyl, nonyl, decyl, undecyl, lauryl, tridecyl, myristyl, pentadecyl, palm
Base, pearly-lustre aliphatic radical, stearyl, nonadecyl, peanut base, behenyl base, haze tallow base, cerul, nonacosyl, α-flax base, ten
Eight carbon apos, two dodecahexaene bases, sub- oil base, are conjugated sub- oil base, γ-flax base, 20 carbon triolefins at eicosapentaenoic base
Base, arachidonic base, oil base, eicosylene base, 20 carbon trialkenyls, mustard base.
R2It is also possible to the substituent group containing elements such as aerobic, nitrogen, sulphur, including but not limited to methylene p-hydroxybenzene, second
Acidic group, amion acetic acid base, propionyloxy, propionamido-, methylmercaptoethyl, methylol, ethoxy, 1- hydroxyethyl, thiopurine methyltransferase, mercapto
Ethyl.
As a preferred technical solution of the present invention, amino acid in the N- acylamino acid be selected from phenylalanine,
Methionine, threonine, isoleucine, leucine, valine, alanine, tyrosine, norvaline, aspartic acid, silk ammonia
Acid, homoserine, cysteine, homocysteine, selenocystein, homocystine, cystine, glutamic acid, glycine, Gao Yi
At least one of leucine, nor-leucine.
X1It can be hydrogen atom, be also possible to alkali metal, such as: sodium, potassium.X1It is also possible to alkaline-earth metal, such as: magnesium,
Calcium.X1It is also possible to ammonium salt, is also possible to alkanolamine residue, wherein alkanolamine can be enumerated such as carbinolamine, dimethanolamine, three
Carbinolamine, ethanol amine, diethanol amine, triethanolamine, Propanolamine, dipropanolamine, tripropanol amine.X1It is also possible to N- alkyl ox sulphur
Hydrochlorate, alkyl can be methyl, ethyl, propyl, isopropyl, and salt can be ammonium salt, sodium salt, sylvite, magnesium salts, calcium salt, diethyl
Alcohol amine salt, triethanolamine salt.Above with respect to X1Enumerate by way of example only, it is not limited to cited substance.
Using water as 100 parts by weight, the content of the N- acyl amino acid surfactant is 30-40 parts by weight.
Nano silver
Since nano silver has great specific surface area, silver ion, the sterilization of nano silver can be dissociateed in aqueous solution
Principle is similar with silver ion, but the effective concentration of nano silver and silver ion is entirely different.The partial size of nano silver is smaller, permeability
Stronger, bactericidal property is stronger.The size of nano-Ag particles is smaller, can easily enter zymoprotein in pathogen, with thallus
Sulfydryl combines rapidly, and some enzymes as necessary group is made to lose vigor, make pathogenic bacteria not energy metabolism and it is dead, to reach
Sterilization, repair tissue, the effect for promoting wound healing.Nano silver in conjunction with DNA of pathogenic base and can form interconnection,
The hydrogen bond in purine and pyrimidine between adjacent nitrogen, bacterium DNA replication Disability are replaced, protein inactivation causes pathogenic bacteria to be lost
It is living.Nano silver can also be reacted with amino, the carboxyl in bacterium, have the function that kill bacterium or mould.Nano silver can kill
Dead staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, streptococcus pyogenes, enterococcus, chlamydia trachomatis, leaching
Coccus etc..
Nano silver can kill a variety of germs being harmful to the human body as new-type wide-spectrum bactericide in a short time, not generate
Any drug resistance.And permeability is strong, can deeply enter from the pore of skin it is subcutaneous, to common bacteria, stubborn bacteria, resistance to
Medicine bacterium and fungus-caused infection have good bactericidal effect.Nano silver can also promote wound healing, improve wound week
The blood circulation of tissue is enclosed, tissue cell growth can be promoted, accelerating wound healing reduces the generation of scar.
As a preferred technical solution of the present invention, the particle size of the nano silver is 1-20nm, preferably 1-
10nm。
The preparation of nano silver can use physical-chemical process and chemical reduction method.Physical-chemical process is divided into light quantum reduction
Method, laser lift-off, high-pressure magnetic sputtering method, ultrasonic method;Chemical reduction method includes silver-amino coordination ion reduction method, electrochemical reduction
Method, reverse micelle method.
Light quantum reduction method is to prepare a kind of important method of nano silver, the basic principle is that producing solution by illumination
The free radical group of raw hydrated electron and reduced form, hydrated electron or free radical group can be with the silver ion in reducing solution, shapes
It at activation silver, activates silver and is continuously accumulated into larger particles, then with high molecular polymer or other medium stable particles, use the method
The reproducibility for preparing nano silver is preferable, and is to carry out at room temperature, also not by the interference for the impurity that may be introduced.Light quantum is also
The reduction process of former method is homogeneous reaction, and there is no the excessive problems of local concentration.Furthermore, it is possible to generate water with ultraviolet light
Change electronics or reduced form free radical group.
Laser lift-off preparation process is as follows, and silver foil is placed on to the bottom of glass container, and 10 milliliters of surfactants are added
The solution of (such as lauryl sodium sulfate or dodecyl sodium sulfate), solvent can be water, butanol, hexane etc..It is focused with laser
The second harmonic that lens generation wavelength is 532nm irradiates silver foil, pulse width 10ns, repetition rate 10Hz.Pass through change
The distance between lens and silver foil adjust the spot size of laser beam to 1-3mm.After laser irradiation silver foil, plasma can be generated
Body makes silver foil be converted into nano-scale particle.Then it by centrifugation, is extracted with decantation.
High-pressure magnetic sputtering method needs inert gas (such as helium, argon, krypton) atmosphere, and gas pressure intensity maintains 3mtorr -1torr
Between, sputtering source can use DC power supply, axial length about 200mm, planar diameter about 50mm, peak power output moon 1kW.Sputtering
Voltage can be about 350V.When forming stable plasma, the nano-Ag particles sputtered can be cooled down from liquid nitrogen instrument
Copper substrate on collect and obtain.The distance of substrate and sample about 5.5cm.
Ultrasonic method is to contain surfactant (such as lauryl sodium sulfate, dodecyl using supersonic generator ultrasound
Benzene sulfonic acid sodium salt, polyvinylpyrrolidone, polyoxyethylene sorbitan monolaurate, polyethylene glycol mono stearate etc.) Ag+
Solution, Ag+It is reduced to obtain nanoscale Argent grain.
Silver-amino coordination ion reduction method is to silver nitrate aqueous solution enriching ammonium hydroxide, and dripping hydrogen peroxide can produce nano silver
Grain reacts as follows:
2Ag(NH3)2 ++H2O2+2OH-=2Ag+O2+4NH3+2H2O
Reaction carries out at low temperature, crystal grain will not occur because of high temperature and grow up, Argent grain system easy to control in size, product granularity point
Cloth is relatively narrow, also than more uniform.Another method is that stabilizer, such as polyvinylpyrrolidine are added into silver-amino coordination ion solution
Ketone, alkyl hydrosulfide, oleic acid and palmitinic acid etc. are nano silver with ascorbic acid or hydrazine hydrate or sodium borohydride reduction silver-amino coordination ion
Particle.Finally manufactured nano-Ag particles are immersed in passivator again, such as oleic acid, then oleic acid is filtered out, vacuum is dry
It is dry, obtain nano-Ag particles.The nano-Ag particles stability that this preparation method obtains is good, good dispersion.
Electrochemical reducing is to prepare nano metal using electrode reaction, the yield height of the method, easily separated, reaction process
Without metal hydride or boron impurity, particle size can be controlled by changing current density, which can produce the silver of 2-7nm
Grain.Metal anode is dissolved in aprotic solvent, the nano-Ag particles produced are pure.
Reverse micelle method is to prepare nano silver with colloid chemistry reduction silver ion.Reverse micelle refers to that surfactant has been dissolved in
In solvent, when concentration is more than critical micelle concentration, hydrophilic radical is formed inwardly, the particle of hydrophobic grouping outwardly.Reverse micelle
Kernel can solubilized hydrone form water core, silver ion is restored in water core and forms nanoparticle.Such as: in reverse micelle, use
Quercetin restores silver nitrate, can be made into the Argent grain of 1-1.5nm.It can also be in α-Al2O3Upper loading nano silvery particle, not
Rust steel utensil on inject silver ion after restore, active carbon nanoparticles area load nano silver, on various fabrics as nylon-11,
Loading nano silvery particle on nylon -66, and on polypropylene non-woven fabric, loading nano silvery particle on pure cotton cloth fabric.
Using water as 100 parts by weight, the content of the nano silver is 0.01-0.15 parts by weight.
Nano-tourmaline
Tourmaline is also referred to as tourmaline, be it is a kind of containing boron, aluminium, sodium, iron, lithium silicate mineral.Its chemical structure can
To be expressed as XY3Z6(T6O18)(BO3)3V3W can have differences according to the different chemical formulas in the place of production and mining area, and wherein X is generally Na
Or Ca K or vacancy.Y location is usually such as Li+、Mg2+、Fe2+、Mn2+、Al3+、Cr3+、V3+、Fe3+、Ti4+Deng
Multivalent state cation.Z location is mainly Tricationic, such as Al3+、Fe3+、Cr3+、V3+Deng being also possible to bivalent cation such as
Mg2+、Fe2+Deng.T location is usually Si, but is also likely to be Al or B according to the difference in the place of production.When these do not know element position
When by element substitutions such as Cr, V, Ti, Fe, Cu, tourmaline takes on a variety of different colors.
Tourmaline has [Si6O18] tripartite's ring structure is answered, belong to trigonal system.Tourmaline has piezoelectricity and pyroelectricity,
In the case that temperature and pressure changes, 1 × 10 can be generated between the lattice of tourmaline6The potential difference of eV, this electrostatic field energy
Enough make air ionization, that is hit is electronically attached to similar hydrone and oxygen molecule, them is made to be converted into negative aeroion.It receives
The other tourmaline specific surface area of meter level is very big, can generate a large amount of negative oxygen ions, also more preferable to the permeability of cell, generation
Negative oxygen ion can remove the intracorporal free radical of people, can delay senescence.Another advantage of tourmaline is can to give off wave
The wave frequency commensurate in scope that a length of 4-14 μm of electromagnetic wave and human body radiation goes out.Wave frequency will produce when matching
Raw resonance, can make one intracorporal water molecule activation, can make the nutritional ingredient of other high molecular weight can when acting on skin surface
To enter cell interior.
As a preferred technical solution of the present invention, the particle size of the nano-tourmaline is 50-100nm.
The preparation method of nano-tourmaline can use mechanochemical reaction, be divided into dry and wet.The particle diameter distribution of dry process
Width, unevenly, energy consumption are high, and the particle diameter distribution of wet process preparation is uniform, is easy to control, but needs by dry, decentralized processing.It can
Tourmaline fission is crushed to 1 μm with airflow milling, then with wet grinding, liquid phase medium uses deionized water, n-butanol, second
Alcohol obtains slurry, and abrasive media (zirconia ball that such as partial size is 1-3mm) is added and grinds certain time afterwards, is dried later
And decentralized processing.Milling time about 2h, the quality of solid and the volume ratio about 1:1 of liquid in slurry, can make to starch when solid is more
Body viscosity increases, and causes grinding machine to can not be successfully grinding, the partial size that tourmaline is obtained when solid is less is larger.The selection of liquid phase medium
Also it will affect particle size, tourmaline belongs to polar particulate, preferably polarizable medium.The viscosity of sample when using water as liquid phase medium
Larger, mobility is poor.Using n-butanol, ethyl alcohol as the viscosity of the sample of liquid phase medium low, good fluidity.
Using water as 100 parts by weight, the content of the nano-tourmaline is 0.05-0.2 parts by weight.
Moisturizing composition
The moisturizing composition is made of hyaluronic acid and collagen.
The average molecular weight of hyaluronic acid be 500,000-200 ten thousand, be largely be present in biology it is intracorporal it is numerous tissue (such as
Subcutaneous tissue, eyeball, joint) polysaccharose substance.Its physiological function be moisture can be made to enter space between cells, and with protein knot
It closes and forms protein gel, cell is sticked together, the cell metabolism effect brought into normal play is played and keeps cell moisture, protection
Cell is accelerated to restore skin histology, improves Wound healing power of regeneration not by the infringement of pathogen, reduces scar, and enhancing is immune
The effects of power.In the present invention, hyaluronic acid refers to forms with 1 or more the disaccharides by glucuronic acid and N-acetyl-glucosamine
Constitutional repeating unit polysaccharide.It is also possible to hyaluronate, hyaluronate is not particularly limited, preferably pharmaceutically
Permissible salt, for example, sodium salt, sylvite, calcium salt, zinc salt, magnesium salts, ammonium salt etc. can be enumerated.
As long as the substance that hyaluronic acid this field generally uses used in the present invention, any substance, can be
The substance extracted from the natural goods such as animal, such as cockscomb, umbilical cord, skin, joint fluid bio-tissue etc., or the micro- life of culture
The chemical syntheses such as the fermentation method of substance obtained by object or zooblast, such as the bacterium that has used streptococcus etc. or enzymatic synthesis
Substance etc. can be used.
Collagen is the main component of skin corium, related with the elasticity of skin is maintained, but since the age increases, skin
Collagen amount is reduced, and the elasticity of skin is impaired, can promote formation or the skin aging of wrinkle.In addition, due to drying, cuticula
Then become shallow wrinkle when the removing of cuticula is slow with epidermis plumpness.The collagen that the present invention uses does not limit especially
It is fixed, use commercially available substance in the form of collagen.The object from ox-hide, pigskin, fish-skin, fish scale, cock skin etc. can be enumerated
Matter.There is no particular limitation for the molecular weight of collagen, it is contemplated that the problem of solubility and skin absorb, then average molecular weight is
3000-100000Da。
Hyaluronic acid and collagen can mutually promote in the absorption of skin surface, the inventors discovered that working as hyaluronic acid
Weight ratio with collagen is 1:(50-100) when, stimulation of the collagen to skin can be eliminated, is not in peculiar smell, heavy
It forms sediment and assembles, no allergic phenomena occurs.And collagen improve permeability of cell membranes, can make the nutrition of more hyaluronic acids at
Divide and is absorbed by the skin.
As a preferred technical solution of the present invention, the weight ratio of the hyaluronic acid and collagen is 1:(50-
100)。
As a preferred technical solution of the present invention, the average molecular weight of the hyaluronic acid is 50000-
2200000Da。
Using water as 100 parts by weight, the content of the moisturizing composition is 0.6-3 parts by weight.
Moisture-keeping composition
The use of present invention cooperation moisture-keeping composition, which is able to suppress, sticks thoughts and feelings that is greasy, astringent, and moistening with dense sense and water,
With excellent use feeling.The moisturizer can be sucrose, D-sorbite, glycerol, 1,3 butylene glycol, propylene glycol, dipropyl two
The sucroses such as alcohol or polyalcohols, 2-100 moles of polyalcohol parent nucleus and propylene oxide in molecule with 3 or more hydroxyls and
Polyethers based compound made of 50 moles of ethylene oxide or less addition polymerizations, ethyl glucuronide alcohol polyethers -10, chondroitin sulfate,
Hyaluronic acid, mucoitin sulfate, Carlow peaceful acid, Atelocollagen albumen, cholesterol -12- hydroxy stearic acid ester, bile acid list
Salt, 2-pyrrolidone-5-carboxylic acid's mono-salt, short chain soluble collagen, Rosa roxburghii Tratt extracting solution, Europe alpine yarrow extract, propylene glycol, dipropylene glycol,
1,3-BDO, 1,4-butanediol, diethylene glycol, triethylene glycol, its above molecular weight the glycols such as polyethylene glycol, glycerol,
The polyglycereol class of diglycerol, its above molecular weight, the sugar such as D-sorbite, mannitol, maltitol, xylitol, antierythrite
Alcohol, the carbohydrates such as fructose, glucose, galactolipin, maltose, lactose, trehalose, polypropylene glycol/ethylene glycol copolymer or secondly
Methyl ether etc..
As a preferred technical solution of the present invention, the moisture-keeping composition is made of glycerol and aloe.
Glycerol is the most common moisturizer in this field, but haves the shortcomings that moisture-retaining capacity is on the weak side.
The main component of aloe is aloe polysaccharide, protein, amino acid etc..Aloe is C12-C14Based on fatty acid
Crude vegetal can be widely used for the fields such as food, cosmetics, medicine, chemical industry comprising 169 kinds of intrinsic beneficiating ingredients of aloe,
There are the irreplaceable health care of other greases and beautification function.Wherein the saturated fatty acid in aloe ingredient accounts for a quarter, includes
Capric acid, lauric acid, myristic acid, pentadecanoic acid, palmitinic acid, Heptadecanoic acide, stearic acid.Unsaturated fatty acid accounts for 3/4ths,
Including palmitoleic acid, hexadecadienoic acid, oleic acid, linoleic acid, linolenic acid.In addition also contain succinic acid, malic acid, lactic acid, right
The organic acids such as coumaric acid.Aloe is because containing carotenoid and aloe-emodin and its derivative, color is muddy in chartreuse
Liquid, main component are Mixed Fatty Glyceride, and oleic acid (cis-9-octadecenoic acid) accounts for chief component.Aloe is
The mixture of triglycerides etc., fusing point and freezing point are a temperature ranges, and generally between 40-50 DEG C, specific gravity is smaller than water, with
Molecular weight increases and reduces, and increases with degree of unsaturation and increases.The refraction index of aloe increases with the increase of molecular weight, with
Double bond increases and increases.Conjugated double bond exists, and has higher refraction index than similar unconjugated double bond compound.
Aloe is retained lignin containing natural colloidality substance, has strong osmoticum, nutrient can be helped to penetrate into flesh
Skin gleditsia sinensis has strength cleaning, antimicrbial power effect, is natural saponin, has anti-inflammatory, detumescence, inhibits bacterial growth, is antipruritic, only
Pain and other effects.With the direct cosmetic result such as moist moisturizing, whitening spot-removing, anti-aging, hypo-allergenic.It plays simultaneously and restrains skin table
Face pathogenic microorganisms and bacterium kill to the harmful acarid of human skin, prevent the breeding of superficial microbes, prevent dermopathic
Occur.It is suitble to Oily, balance inhibits sebum secretion, promotes wound healing.
Beta carotene contained in aloe can enhance radiation and chemotherapy to the curative effect of tumour, and reduce them to body
Poison pay effect, improve the immune function of host.The pre- preventing tumor of beta carotene and adjuvant therapy treatment effect with it is anti-oxidant
Property is closely related.Contain multiple conjugated double bonds in beta carotene, is a good antioxidant, therefore body can be improved
Function of detoxification is conducive to carcinogenic substance fast deactivation, also has inhibiting effect to the activation of precarcinogen, beta carotene can also be sudden
It goes out and free radical and prevents the generation of free radical that from capable of effectively inhibiting caused by free radical similar to the effect of hepatocuprein
Lipid peroxidation.
Aloe and glycerol are used in mixed way as moisturizer, can obtain more permanent moistening effect, cooperate moisturizing group
Close object together, replenishing water and preserving moisture effect is more preferable.
As a preferred technical solution of the present invention, the weight ratio of the aloe and glycerol is 1:(40-100).
As a preferred technical solution of the present invention, the kinematic viscosity of the aloe is 0.5-1.5mm2/s。
Using water as 100 parts by weight, the content of the moisture-keeping composition is 10-30 parts by weight.
Nanometer tea powder
As a preferred technical solution of the present invention, the nanometer tea powder is selected from nanometer green tea powder.
Green tea from the tea tree of tea tree section bud or leaf, it is not fermented, through the techniques such as water-removing, shaping, drying production and
At.Green tea is not fermented manufactured tea, remains the natural materials of fresh leaf, tea polyphenols, catechin, chlorophyll, the coffee contained
Coffee alkali, amino acid, vitamins and other nutritious components are also more.The processing of green tea is simply divided into water-removing, rubs and dry three steps
Suddenly, wherein key is to finish.Fresh leaf is not having substantially by water-removing, the active passivation of enzyme, the various chemical components included
Under conditions of having enzyme influence, physicochemical change is carried out by thermodynamic activity, so as to form the qualitative characteristics of green tea.In green tea
These natural nutrition compositions have special-effect to anti-aging, anti-cancer, anticancer, sterilization, anti-inflammatory etc., are less than other teas
's.
Nanometer green tea powder has excellent skin stability, can promote the gene activity declined by aging once again, improves
The absorption of collagen and hyaluronic acid fundamentally improves the skin of aging, to following the string and the skin tape of gloss is lived
Power.
The nanometer tea powder is to be made after the zirconia ball that partial size is 1-3mm is added with ball mill grinding.
Using water as 100 parts by weight, the content of the nanometer tea powder is 0.08-1.5 parts by weight.
It is other
Whitening anti-aging anti-wrinkle women private portion articles of the invention also can according to need the other additives of cooperation, right
It can be suitable for selecting in the range of not impairing the effect of the present invention in its type and use level.It, can as other additives
It enumerates for example: fragrance, pigment, salt, pearling agent, colorant, medicament, thickener, ultraviolet absorbing agent, coagent, pH tune
Save agent etc..
A kind of preparation method of whitening anti-aging anti-wrinkle women private as described above portion articles, comprises the following steps:
(1) N- acyl amino acid surfactant, aloe, glycerol, water are added in container A, is heated to 50-70 DEG C and stirs
It mixes uniformly;
(2) nano-tourmaline, nano silver, nanometer tea powder, water are added in container B, stirs evenly at room temperature;
(3) mixture in container B pours into container A, sequentially adds hyaluronic acid, collagen at room temperature, stirring
Filling after uniformly, packaging.
Hereinafter, the present invention is explained in more detail by embodiment, it should be appreciated that these embodiments are only
Illustrate and not restrictive.If raw materials used to be all commercially available without other explanations.
Referring to several example the present invention is described in detail.
Component A is N- acyl amino acid surfactant, and component B is nano silver, and component C is nano-tourmaline, and component D is
Moisturizing composition, component E are moisture-keeping composition, and component F is nanometer tea powder.
A1 sodium lauroyl glutamate aginomoto LS-11
A2 cocoyl alanine triethanolamine salt aginomoto ACT-12
A3 cocoyl glycine potassium aginomoto GCK-12K
The big science and technology JDTKS-001 in the Shanxi B1 nano silver partial size 5nm
Auspicious (Shanghai) Chemical Co., Ltd. of B2 nano silver partial size 15nm space
C nano tourmaline Tianjin swan goose tienshanite industry Nanosolutions GmbH partial size 75nm
The weight ratio of D1 hyaluronic acid-collagen hyaluronic acid and collagen is 1:50, the average mark of hyaluronic acid
Son amount about 2000000Da, hyaluronic acid Xi'an Ze Bang Biotechnology Co., Ltd, collagen Xi'an Rayleigh biotechnology are limited
Company
The weight ratio of D2 hyaluronic acid-collagen hyaluronic acid and collagen is 1:75, the average mark of hyaluronic acid
Son amount about 800000Da, hyaluronic acid Xi'an Ze Bang Biotechnology Co., Ltd, collagen Xi'an Rayleigh biotechnology are limited
Company
The weight ratio of D3 hyaluronic acid-collagen hyaluronic acid and collagen is 1:100, the average mark of hyaluronic acid
Son amount about 50000Da, hyaluronic acid Xi'an Ze Bang Biotechnology Co., Ltd, the limited public affairs of collagen Xi'an Rayleigh biotechnology
Department
D4 collagen Xi'an Rayleigh Biotechnology Co., Ltd
E1 aloe-glycerol aloe kinematic viscosity is 0.54mm2The weight ratio of/s, aloe and glycerol is 1:40,
This daily use chemicals development in science and technology Co., Ltd of the aloe Guangzhou Chinese one hundred, natural oil Chemical Co., Ltd., glycerol Malaysia
E2 aloe-glycerol aloe kinematic viscosity is 1.42mm2The weight ratio of/s, aloe and glycerol is 1:70,
Aloe Guangzhou is refined to cosmetics Co., Ltd, natural oil Chemical Co., Ltd., glycerol Malaysia
E3 aloe-glycerol aloe kinematic viscosity is 2.33mm2The weight ratio of/s, aloe and glycerol is 1:100,
Aloe Guangzhou Pin Ding Chemical Industry Science Co., Ltd, natural oil Chemical Co., Ltd., glycerol Malaysia
Natural oil Chemical Co., Ltd., E4 glycerol Malaysia
F nanometers of green tea powder Zhuji City Yi Meiya daily necessities Co., Ltds