CN105581330A - Multivitamin Ca-Fe-Zn-Se tablets for middle-aged and elderly people - Google Patents
Multivitamin Ca-Fe-Zn-Se tablets for middle-aged and elderly people Download PDFInfo
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- CN105581330A CN105581330A CN201510962764.3A CN201510962764A CN105581330A CN 105581330 A CN105581330 A CN 105581330A CN 201510962764 A CN201510962764 A CN 201510962764A CN 105581330 A CN105581330 A CN 105581330A
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- 229920002472 Starch Polymers 0.000 claims abstract description 46
- 239000008107 starch Substances 0.000 claims abstract description 46
- 235000019698 starch Nutrition 0.000 claims abstract description 46
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 25
- 239000000203 mixture Substances 0.000 claims abstract description 24
- 239000000843 powder Substances 0.000 claims abstract description 24
- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 229920000881 Modified starch Polymers 0.000 claims abstract description 7
- 239000004368 Modified starch Substances 0.000 claims abstract description 7
- 239000011248 coating agent Substances 0.000 claims abstract description 7
- 238000000576 coating method Methods 0.000 claims abstract description 7
- 235000019426 modified starch Nutrition 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 239000011669 selenium Substances 0.000 claims description 16
- 229910052711 selenium Inorganic materials 0.000 claims description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 15
- 239000011780 sodium chloride Substances 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 238000013019 agitation Methods 0.000 claims description 6
- 229910021538 borax Inorganic materials 0.000 claims description 6
- 238000001556 precipitation Methods 0.000 claims description 6
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 6
- 235000010234 sodium benzoate Nutrition 0.000 claims description 6
- 239000004299 sodium benzoate Substances 0.000 claims description 6
- 235000002639 sodium chloride Nutrition 0.000 claims description 6
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 6
- 239000004328 sodium tetraborate Substances 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- 229910052802 copper Inorganic materials 0.000 claims description 4
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 4
- 238000007873 sieving Methods 0.000 claims description 4
- 239000000377 silicon dioxide Substances 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 239000004408 titanium dioxide Substances 0.000 claims description 4
- 241000132012 Atractylodes Species 0.000 claims description 3
- 241001546929 Campsis grandiflora Species 0.000 claims description 3
- 244000037364 Cinnamomum aromaticum Species 0.000 claims description 3
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims description 3
- 240000004307 Citrus medica Species 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 241000234435 Lilium Species 0.000 claims description 3
- 240000005001 Paeonia suffruticosa Species 0.000 claims description 3
- 235000003889 Paeonia suffruticosa Nutrition 0.000 claims description 3
- 230000009471 action Effects 0.000 claims description 3
- 230000032683 aging Effects 0.000 claims description 3
- 238000000889 atomisation Methods 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 3
- 238000006253 efflorescence Methods 0.000 claims description 3
- 235000021050 feed intake Nutrition 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 239000008240 homogeneous mixture Substances 0.000 claims description 3
- 238000009413 insulation Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000006386 neutralization reaction Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 229920001592 potato starch Polymers 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- 230000037452 priming Effects 0.000 claims description 3
- 206010037844 rash Diseases 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 241000005787 Cistanche Species 0.000 claims description 2
- 244000197580 Poria cocos Species 0.000 claims description 2
- 235000008599 Poria cocos Nutrition 0.000 claims description 2
- 241000220317 Rosa Species 0.000 claims description 2
- 235000012730 carminic acid Nutrition 0.000 claims description 2
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract description 19
- 239000011707 mineral Substances 0.000 abstract description 19
- 235000010755 mineral Nutrition 0.000 abstract description 19
- 239000003814 drug Substances 0.000 abstract description 11
- 235000015097 nutrients Nutrition 0.000 abstract description 11
- 230000036541 health Effects 0.000 abstract description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract description 4
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 abstract description 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 abstract description 3
- 229930003471 Vitamin B2 Natural products 0.000 abstract description 3
- 229930003316 Vitamin D Natural products 0.000 abstract description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract description 3
- 229960002477 riboflavin Drugs 0.000 abstract description 3
- 235000019164 vitamin B2 Nutrition 0.000 abstract description 3
- 239000011716 vitamin B2 Substances 0.000 abstract description 3
- 235000019166 vitamin D Nutrition 0.000 abstract description 3
- 239000011710 vitamin D Substances 0.000 abstract description 3
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract description 3
- 229940046008 vitamin d Drugs 0.000 abstract description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 abstract description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 abstract description 2
- 229930003451 Vitamin B1 Natural products 0.000 abstract description 2
- 229930003268 Vitamin C Natural products 0.000 abstract description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract description 2
- 230000001502 supplementing effect Effects 0.000 abstract description 2
- 229960003495 thiamine Drugs 0.000 abstract description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 abstract description 2
- 235000019155 vitamin A Nutrition 0.000 abstract description 2
- 239000011719 vitamin A Substances 0.000 abstract description 2
- 235000010374 vitamin B1 Nutrition 0.000 abstract description 2
- 239000011691 vitamin B1 Substances 0.000 abstract description 2
- 235000019154 vitamin C Nutrition 0.000 abstract description 2
- 239000011718 vitamin C Substances 0.000 abstract description 2
- 229940045997 vitamin a Drugs 0.000 abstract description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 abstract 2
- 229920001353 Dextrin Polymers 0.000 abstract 1
- 239000004375 Dextrin Substances 0.000 abstract 1
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 abstract 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 abstract 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 abstract 1
- 229930003427 Vitamin E Natural products 0.000 abstract 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 abstract 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 abstract 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 abstract 1
- 229960002079 calcium pantothenate Drugs 0.000 abstract 1
- 235000019425 dextrin Nutrition 0.000 abstract 1
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000011773 ferrous fumarate Substances 0.000 abstract 1
- 235000002332 ferrous fumarate Nutrition 0.000 abstract 1
- 229960000225 ferrous fumarate Drugs 0.000 abstract 1
- 229960000304 folic acid Drugs 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 1
- 235000021552 granulated sugar Nutrition 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 abstract 1
- 239000008108 microcrystalline cellulose Substances 0.000 abstract 1
- 229940016286 microcrystalline cellulose Drugs 0.000 abstract 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011781 sodium selenite Substances 0.000 abstract 1
- 229960001471 sodium selenite Drugs 0.000 abstract 1
- 235000015921 sodium selenite Nutrition 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 235000019158 vitamin B6 Nutrition 0.000 abstract 1
- 239000011726 vitamin B6 Substances 0.000 abstract 1
- 235000019165 vitamin E Nutrition 0.000 abstract 1
- 239000011709 vitamin E Substances 0.000 abstract 1
- 229940046009 vitamin E Drugs 0.000 abstract 1
- 229940011671 vitamin b6 Drugs 0.000 abstract 1
- 239000011670 zinc gluconate Substances 0.000 abstract 1
- 235000011478 zinc gluconate Nutrition 0.000 abstract 1
- 229960000306 zinc gluconate Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 description 13
- 235000013343 vitamin Nutrition 0.000 description 13
- 239000011782 vitamin Substances 0.000 description 13
- 229940088594 vitamin Drugs 0.000 description 13
- 150000003722 vitamin derivatives Chemical class 0.000 description 9
- 239000000463 material Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 6
- 230000003203 everyday effect Effects 0.000 description 4
- 239000000706 filtrate Substances 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 4
- 206010013911 Dysgeusia Diseases 0.000 description 3
- 230000002354 daily effect Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 235000001465 calcium Nutrition 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- NHZMQXZHNVQTQA-UHFFFAOYSA-N pyridoxamine Chemical compound CC1=NC=C(CO)C(CN)=C1O NHZMQXZHNVQTQA-UHFFFAOYSA-N 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 239000003390 Chinese drug Substances 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 201000002451 Overnutrition Diseases 0.000 description 1
- 241001619461 Poria <basidiomycete fungus> Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 235000018823 dietary intake Nutrition 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229940029985 mineral supplement Drugs 0.000 description 1
- 235000020786 mineral supplement Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000020772 multivitamin supplement Nutrition 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 235000020823 overnutrition Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 235000008151 pyridoxamine Nutrition 0.000 description 1
- 239000011699 pyridoxamine Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000000779 smoke Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention provides multivitamin Ca-Fe-Zn-Se tablets for middle-aged and elderly people and related to the field of drugs. The multivitamin Ca-Fe-Zn-Se tablets for middle-aged and elderly people are prepared from 1.43 g of vitamin A (9.75%), 480 mg of vitamin B1, 400 mg of vitamin B2, 420 mg of vitamin B6, 3.85 g of nicotinamide, 110 mg of folic acid, 1.5 g of calcium pantothenate, 27.5 g of vitamin C, 2.6 mg of vitamin D, 7.5 g of vitamin E (50%), 674 g of calcium carbonate, 13.7 g of ferrous fumarate, 28 g of zinc gluconate, 26 mg of sodium selenite, 200 g of modified starch, 40 g of dextrin, 30 g of sodium carboxymethyl starch, 100 g of white granulated sugar, 30 g of microcrystalline cellulose, 6 g of magnesium stearate, 15 g of calcium carbonate composition and 35 g of coating powder, and the raw materials are made into 1000 coating tablets. The multivitamin Ca-Fe-Zn-Se tablets are designed for middle-aged and elderly people and can help middle-aged and elderly people take nutrients reasonably, and the expected health care function of supplementing multivitamins and mineral substances can be realized.
Description
Technical field
The present invention relates to medicine field, relate in particular to a kind of middle-aged and old type multivitamin ferro-calcium-zinc-selenium sheet.
Background technology
In recent years, along with China's expanding economy, material is greatly abundant, and people's living standard has had veryLarge raising, the general level of the health has also had obvious improvement. Three large nutrient (fat, albumen, carbon hydrateThing) substantially can meet people's life requirement, but some mineral matters and micro-shortage,But people's health in serious harm. Human body all need to obtain various nutriments every day from mealsMaintain its existence, health and social life.
Vitamin and mineral matter are to maintain a healthy necessary class organic compound, and this class material existsIn human body neither form systemic raw material, the source neither human body energy producing, but a classAuto-regulator plays an important role in metabolism. This class material is not enough owing to can not synthesizing in body or synthesizing,Although seldom (only calculate with milligram or microgram every day) but must rely on the frequent supply of food of requirement,Could keep the normal need of body, so human body be unable to do without vitamin and mineral matter. According to Chinese nutritionA national nutrition survey can recently announcing shows, along with carrying of expanding economy and income level of residentHeight, there are great changes in Chinese residents diet structure and life style, due to overnutrition or imbalanceDue to chronic disease increasing, Chinese lack vitamin and mineral matter insufficiency of intake and unbalanced phenomenonUbiquity. The nutrition of the famine of population of China have vitamin A, B2 and calcium, and what generally lack hasVitamin B1, pyridoxamine, vitamin C, vitamin D, iron, zinc etc. Lacking of vitamin and mineral matterWeary and uneven, can cause other nutrients not to be absorbed and utilized by the body, cause various diseases, veryTo causing death. Nutritionist points out, keeps balanced in nutrition, and appropriate replenishing vitamins and mineral matter are mendedIt is useful filling agent. People's idea changes " anosis master into from original " ill passive treatment " at presentMoving prevention ". Can foretell, take the custom of multivitamin and mineral supplements in China every day,The new trend of health of people consumption will be become.
Show according to investigations, along with the raising of economic level and enriching of food, although typical nutrient lacksWeary disease patient is fewer and feweri, and vitamin and mineral matter insufficiency of intake and unbalanced phenomenon are but further normalSeeing, is mainly to be caused by the change of unsound life style and eating habit. On the one hand along with workThe quickening of rhythm, stays up late, do not have enough sleep, smoke, drink and other unsound life styles for strongHealth is buried various hidden danger. On the other hand, due to dietary intake become more meticulous and partial eclipse particular about food, having canCan cause the insufficiency of intake of human body for vitamin and mineral matter. People are but difficult to accomplish that daily nutrition element takes the photographEnter equilibrium, so suitably replenishing vitamins mineral matter is necessary. The need of human body to vitamin and mineral matterSeeking Truth is diversified, and we are daily is difficult to understand that oneself lacks what kind of vitamin and mineral matter on earth,Therefore need to supplement comprehensive vitamin and minerals and meet the human body demand of every day. Moreover, various supporting one's familyBetween element mineral matter, have very important " working in coordination with " effect, i.e. a kind of existence of nutrient can promoteThe absorption of other nutrients and utilization. For example vitamin B1 improves the utilization rate of vitamin B2, vitamin D sideHelp the absorption of calcium and utilization etc. Therefore need comprehensive replenishing vitamins and mineral matter, meet people to battalionSupport the daily demand of element.
Due to China's diet structure, the supplementary precautionary measures that become easily and effectively of nutrient.Although have now the replenishing vitamins of a multitude of names and the product of mineral matter to sell on market, often only noteThe a certain single nutrient of meaning strengthening and ignored the concept of the mutual equilibrium between nutrient. In the marketMultidimensional flake products mainly contains doctor's Xiao board multidimensional sheet, dimension Heng board multidimensional sheet, dimension weighing apparatus board multidimensional sheet, permanent safe boardMultidimensional sheet, though these products are also for supplementing the product of multivitamin and mineral matter, institute in formula for a productOf a great variety with auxiliary material complexity, additive and synthetic dyestuff, and applicable crowd is more wide in range, and specific aim is notBy force, functional component is comparatively single, and the synergy between each component is left in the basket, and component and component content are establishedCount unreasonable.
Summary of the invention
The object of the present invention is to provide a kind of middle-aged and old type multivitamin ferro-calcium-zinc-selenium sheet, on solvingState technical problem.
Technical problem to be solved by this invention realizes by the following technical solutions:
A kind of middle-aged and old type multivitamin ferro-calcium-zinc-selenium sheet, is characterized in that: prepared by following raw materialForm:
Make 1000 coating tablets;
Described calcium carbonate composition is by 20 parts of medical Paris whites, 0.3 part of nano-silica powder, diatomite8 parts of 0.5 parts, shell powder; Calcium carbonate composition is formed by weight even mixing, sterilizing by above-mentioned raw materials;
Described coating powder is made up of famille rose, sunset yellow, titanium dioxide, talcum powder, Hydroxypropyl methylcellulose,Wherein carmine 0.1% (quality), sunset yellow 0.3% (quality), titanium dioxide 30% (quality), talcumPowder 11.6% (quality), Hydroxypropyl methylcellulose 58% (quality).
Described modified starch is to make in the following manner:
1) neutralization reaction
Pour in reactor farina into while stirring injected water steam, in steam, contain volume integralNumber is 0.5% alcohol gas, and the steam temperature in reactor reaches under the condition of 135 DEG C, allows Ma LingSweet potato starch is fully stirred in reactor, and it is heated evenly, and adds thermal agitation 25 minutes, to starchSlaking completely;
2) feed intake
Aging starch is taken out from reactor, put into retort and note clear water and be stirred to without particle, formThe homogeneous mixture of starch and water, in this mixture, the mass fraction of starch is 60%;
3) precipitation
Allow starch soak fully, evenly mixture to be shifted out from retort, put into pond and precipitate, warpAfter the precipitation of 5-7 days, the starch solution of topmost having clarified in water intaking pond is produced for subsequent use; Lower floor in pondThe fecula stirring that adds water, heats, gets the starch solution of having clarified above for subsequent use, until can not levigation liquidTill state clear liquid;
4) insulation is hydrolyzed the enzyme that goes out
Be drawn onto in retort clarifying starch solution, to water filling steam in retort, make the shallow lake of having clarifiedPowder solution is heated to 60 DEG C, plays and sizes mixing and the go out effect of enzyme of high temperature, while adding thermal agitation in constantly stirringBetween be 20-40 minute; Then add wooden carbon ash decolouring slagging-off; Finally by crossing Filter Press, flow out thorough clearlyThe starch solution seeing the bottom;
5) receiving clear water concentrates
By the starch solution after decolouring deslagging filtering, inject vacuum concentration pot, concentrated starch solution BaumeDegree is at 32 degree;
6) batching
Heat in the starch solution of 32 degree is drawn into agitator tank from vacuum concentration pot being concentrated to Baume degreesTo 65 DEG C, by farina, borax, sodium benzoate, sodium chloride mass ratio be: 50:1:0.5:0.1, pour borax, sodium benzoate and sodium chloride into, heat stir under be fully dissolved in starch fluid, useDeionized water washing is extremely without CL-;
7) high temperature centrifugal spray
The complete starch solution self priming pump of preparing burden is injected in the tank on the centrifugal tower of high temperature and is treatedWith, ensureing under starch solution 65 DEG C of temperature conditions, with funnel slowly add in the centrifugal tower of high temperature at a high speed fromIn scheming, in the centrifugal tower of high temperature, vapor (steam) temperature remains on more than 150 DEG C simultaneously, makes the starch solution having concentratedUnder the double action through High Rotation Speed centrifuge and high-temperature gas, form atomization, efflorescence, finally drop onAt the bottom of tower, inside is powdery, obtains modified starch.
Described shell powder is pulverized by clam shell, is placed in the dry stir-fry of copper pot, treats that shell powder is yellowish-brown, raw meatCooling sieving after taste volatilization totally.
Calcium carbonate composition is formed by weight even mixing, sterilizing by above-mentioned raw materials, mixed carbonic acidCalcium composition CaCO3Content is high, and impurity content is low, and has granularity and the adjustable spy of bulk densityPoint.
Described shell powder is pulverized by clam shell, is placed in the dry stir-fry of copper pot, treats that shell powder is yellowish-brown, raw meatCooling sieving after taste volatilization totally. In calcium carbonate composition, add a certain proportion of shell powder, not onlyGranularity and bulk density can be regulated, and cohesive and the plasticity of calcium carbonate composition can be increased,For the preparation of medicament, utilize industry to change into product. Diatomite composition can increase calcium carbonate composition equallyPlasticity, and with nano-silica powder coupling, in pharmacy procedure, can adsorpting formulation assortedMatter, peculiar smell etc. destroy the material of medicament quality.
The raw material of preparing middle-aged and old type multivitamin ferro-calcium-zinc-selenium sheet also comprise: 4 parts of (matter of saline cistancheAmount), the bighead atractylodes rhizome 6 (quality), 2 parts of the dried immature fruit of citron oranges (quality), radix rehmanniae recen 5 parts of (quality), 3 parts of (matter of Poria cocosAmount), lily 4 parts of (quality), fig 10 parts of (quality), cassia seed 8 parts of (quality), radix polygonati officinalis 4Part (quality), Chinese trumpet creeper 2 parts (quality), fry the root bark of tree peony 5 parts (quality), RADIX ACONITILATERALIS PREPARATA 5 parts (quality),7 parts of rhizoma zingiberis (quality).
Above-mentioned Chinese medicine composition after mixture, is soaked 30min in proportion, then boils 25min, filtersGet filtrate, in filter residue, add clear water to continue component 20min, filter for the second time, get filtrate, by twice filterLiquid merges, concentrated, and spraying is dry, makes traditional Chinese medicine powder; Get traditional Chinese medicine powder 25g and other material component, adoptConventional pharmaceutical methods, makes 1000 of middle-aged and old type multivitamin ferro-calcium-zinc-selenium sheets.
The Chinese medicinal ingredients containing in multivitamin ferro-calcium-zinc-selenium sheet, can carry out the health of mid-aged populationConditioning, improves absorbing of the mineral matters such as multivitamin and ferro-calcium-zinc-selenium.
The invention has the beneficial effects as follows:
Multivitamin ferro-calcium-zinc-selenium sheet provided by the invention, for person in middle and old age's design, can helpMid-aged population is reasonably taken in nutrient, and expectability reaches the health care that supplements multivitamin and mineral matterFunction. The present invention supplements theoretical according to modern nutrient, the consumption between the each component of appropriate design makes eachThe well effect of performance Synergistic between component, the present invention has definite functions, quality controllable, clothesBy features such as safety.
Detailed description of the invention
For technological means, creation characteristic that the present invention is realized, reach object and effect is easy to understandSeparate, below in conjunction with specific embodiment, further set forth the present invention, but following embodiment is only the present inventionPreferred embodiment, not all. Based on the embodiment in embodiment, those skilled in the art are not havingThere is lower other embodiment that obtains of prerequisite that makes creative work, all belong to protection scope of the present invention.
A kind of middle-aged and old type multivitamin ferro-calcium-zinc-selenium sheet, is characterized in that: prepared by following raw materialForm:
Make 1000 coating tablets;
Traditional Chinese medicine powder is formed by the Chinese drug preparation of following weight portion: 4 parts of saline cistanches (quality), the bighead atractylodes rhizome 6 (matterAmount), 2 parts of the dried immature fruit of citron oranges (quality), 4 parts of radix rehmanniae recen 5 parts (quality), Poria cocos 3 parts (quality), lilies(quality), fig 10 parts (quality), cassia seed 8 parts (quality), radix polygonati officinalis 4 parts (quality),Chinese trumpet creeper 2 parts of (quality), the stir-fry root bark of tree peony 5 parts of (quality), RADIX ACONITILATERALIS PREPARATA 5 parts of (quality), 7 parts of (matter of rhizoma zingiberisAmount);
Above-mentioned Chinese medicine composition after mixture, is soaked 30min in proportion, then boils 25min, filtersGet filtrate, in filter residue, add clear water to continue component 20min, filter for the second time, get filtrate, by twice filterLiquid merges, concentrated, and spraying is dry, makes traditional Chinese medicine powder; Get traditional Chinese medicine powder 25g and other material component, adoptConventional pharmaceutical methods, makes 1000 of middle-aged and old type multivitamin ferro-calcium-zinc-selenium sheets.
Described modified starch is to make in the following manner:
1) neutralization reaction
Pour in reactor farina into while stirring injected water steam, in steam, contain volume integralNumber is 0.5% alcohol gas, and the steam temperature in reactor reaches under the condition of 135 DEG C, allows Ma LingSweet potato starch is fully stirred in reactor, and it is heated evenly, and adds thermal agitation 25 minutes, to starchSlaking completely;
2) feed intake
Aging starch is taken out from reactor, put into retort and note clear water and be stirred to without particle, formThe homogeneous mixture of starch and water, in this mixture, the mass fraction of starch is 60%;
3) precipitation
Allow starch soak fully, evenly mixture to be shifted out from retort, put into pond and precipitate, warpAfter the precipitation of 5-7 days, the starch solution of topmost having clarified in water intaking pond is produced for subsequent use; Lower floor in pondThe fecula stirring that adds water, heats, gets the starch solution of having clarified above for subsequent use, until can not levigation liquidTill state clear liquid;
4) insulation is hydrolyzed the enzyme that goes out
Be drawn onto in retort clarifying starch solution, to water filling steam in retort, make the shallow lake of having clarifiedPowder solution is heated to 60 DEG C, plays and sizes mixing and the go out effect of enzyme of high temperature, while adding thermal agitation in constantly stirringBetween be 20-40 minute; Then add wooden carbon ash decolouring slagging-off; Finally by crossing Filter Press, flow out thorough clearlyThe starch solution seeing the bottom;
5) receiving clear water concentrates
By the starch solution after decolouring deslagging filtering, inject vacuum concentration pot, concentrated starch solution BaumeDegree is at 32 degree;
6) batching
Heat in the starch solution of 32 degree is drawn into agitator tank from vacuum concentration pot being concentrated to Baume degreesTo 65 DEG C, by farina, borax, sodium benzoate, sodium chloride mass ratio be: 50:1:0.5:0.1, pour borax, sodium benzoate and sodium chloride into, heat stir under be fully dissolved in starch fluid, useDeionized water washing is extremely without CL-;
7) high temperature centrifugal spray
The complete starch solution self priming pump of preparing burden is injected in the tank on the centrifugal tower of high temperature and is treatedWith, ensureing under starch solution 65 DEG C of temperature conditions, with funnel slowly add in the centrifugal tower of high temperature at a high speed fromIn scheming, in the centrifugal tower of high temperature, vapor (steam) temperature remains on more than 150 DEG C simultaneously, makes the starch solution having concentratedUnder the double action through High Rotation Speed centrifuge and high-temperature gas, form atomization, efflorescence, finally drop onAt the bottom of tower, inside is powdery, obtains high strength modified starch products;
Described calcium carbonate composition is by 20 parts of medical Paris whites, 0.3 part of nano-silica powder, diatomite8 parts of 0.5 parts, shell powder;
Calcium carbonate composition is formed by weight even mixing, sterilizing by above-mentioned raw materials.
Described shell powder is pulverized by clam shell, is placed in the dry stir-fry of copper pot, treats that shell powder is yellowish-brown, raw meatCooling sieving after taste volatilization totally.
More than show and described general principle of the present invention, principal character and advantage of the present invention. One's own professionThe technical staff of industry should understand, and the present invention is not restricted to the described embodiments, above-described embodiment and explanationIn book, describe only for preference of the present invention, be not used for limiting the present invention, do not departing from essence of the present inventionUnder the prerequisite of god and scope, the present invention also has various changes and modifications, and these changes and improvements all fall intoIn the claimed scope of the invention. The claimed scope of the present invention by appending claims and etc.Effect thing defines.
Claims (4)
1. a middle-aged and old type multivitamin ferro-calcium-zinc-selenium sheet, is characterized in that: by following raw material systemStandby forming:
Make 1000 coating tablets;
Described calcium carbonate composition is by 20 parts of medical Paris whites, 0.3 part of nano-silica powder, diatomite8 parts of 0.5 parts, shell powder; Calcium carbonate composition is formed by weight even mixing, sterilizing by above-mentioned raw materials;
Described coating powder is made up of famille rose, sunset yellow, titanium dioxide, talcum powder, Hydroxypropyl methylcellulose,Wherein carmine 0.1% (quality), sunset yellow 0.3% (quality), titanium dioxide 30% (quality), talcumPowder 11.6% (quality), Hydroxypropyl methylcellulose 58% (quality).
2. middle-aged and old type multivitamin ferro-calcium-zinc-selenium sheet according to claim 1, is characterized in that:Described modified starch is to make in the following manner:
1) neutralization reaction
Pour in reactor farina into while stirring injected water steam, in steam, contain volume integralNumber is 0.5% alcohol gas, and the steam temperature in reactor reaches under the condition of 135 DEG C, allows Ma LingSweet potato starch is fully stirred in reactor, and it is heated evenly, and adds thermal agitation 25 minutes, to starchSlaking completely;
2) feed intake
Aging starch is taken out from reactor, put into retort and note clear water and be stirred to without particle, formThe homogeneous mixture of starch and water, in this mixture, the mass fraction of starch is 60%;
3) precipitation
Allow starch soak fully, evenly mixture to be shifted out from retort, put into pond and precipitate, warpAfter the precipitation of 5-7 days, the starch solution of topmost having clarified in water intaking pond is produced for subsequent use; Lower floor in pondThe fecula stirring that adds water, heats, gets the starch solution of having clarified above for subsequent use, until can not levigation liquidTill state clear liquid;
4) insulation is hydrolyzed the enzyme that goes out
Be drawn onto in retort clarifying starch solution, to water filling steam in retort, make the shallow lake of having clarifiedPowder solution is heated to 60 DEG C, plays and sizes mixing and the go out effect of enzyme of high temperature, while adding thermal agitation in constantly stirringBetween be 20-40 minute; Then add wooden carbon ash decolouring slagging-off; Finally by crossing Filter Press, flow out thorough clearlyThe starch solution seeing the bottom;
5) receiving clear water concentrates
By the starch solution after decolouring deslagging filtering, inject vacuum concentration pot, concentrated starch solution BaumeDegree is at 32 degree;
6) batching
Heat in the starch solution of 32 degree is drawn into agitator tank from vacuum concentration pot being concentrated to Baume degreesTo 65 DEG C, by farina, borax, sodium benzoate, sodium chloride mass ratio be: 50:1:0.5:0.1, pour borax, sodium benzoate and sodium chloride into, heat stir under be fully dissolved in starch fluid, useDeionized water washing is extremely without CL-;
7) high temperature centrifugal spray
The complete starch solution self priming pump of preparing burden is injected in the tank on the centrifugal tower of high temperature and is treatedWith, ensureing under starch solution 65 DEG C of temperature conditions, with funnel slowly add in the centrifugal tower of high temperature at a high speed fromIn scheming, in the centrifugal tower of high temperature, vapor (steam) temperature remains on more than 150 DEG C simultaneously, makes the starch solution having concentratedUnder the double action through High Rotation Speed centrifuge and high-temperature gas, form atomization, efflorescence, finally drop onAt the bottom of tower, inside is powdery, obtains modified starch.
3. middle-aged and old type multivitamin ferro-calcium-zinc-selenium sheet according to claim 1, is characterized in that:Described shell powder is pulverized by clam shell, is placed in the dry stir-fry of copper pot, treats that shell powder is yellowish-brown, and fishy smell is wavedCooling sieving after sending out totally.
4. middle-aged and old type multivitamin ferro-calcium-zinc-selenium sheet according to claim 1, is characterized in that:The raw material of preparing middle-aged and old type multivitamin ferro-calcium-zinc-selenium sheet also comprise: 4 parts of saline cistanches (quality),The bighead atractylodes rhizome 6 (quality), 2 parts of the dried immature fruit of citron oranges (quality), radix rehmanniae recen 5 parts (quality), Poria cocos 3 parts (quality),Lily 4 parts of (quality), fig 10 parts of (quality), cassia seed 8 parts of (quality), 4 parts of (matter of radix polygonati officinalisAmount), Chinese trumpet creeper 2 parts (quality), fry the root bark of tree peony 5 parts of (quality), RADIX ACONITILATERALIS PREPARATA 5 parts of (quality), rhizoma zingiberis7 parts (quality).
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CN101716194A (en) * | 2008-12-02 | 2010-06-02 | 天津天狮生物发展有限公司 | Multi-flavor chewable calcium tablets and production process thereof |
CN103599546A (en) * | 2013-10-30 | 2014-02-26 | 界首市东亚淀粉出品有限公司 | Renewable calcium tablet filler containing modified starch |
CN103734582A (en) * | 2014-01-23 | 2014-04-23 | 甘南倍益特生物科技有限公司 | Yak lactoprotein polypeptide nutrition powder applicable to middle-aged and aged people and preparation method of powder |
CN105124606A (en) * | 2015-09-07 | 2015-12-09 | 天津市康瑞药业有限公司 | Composite vitamin complementing tablet suitable for middle-aged males and aged males |
-
2015
- 2015-12-17 CN CN201510962764.3A patent/CN105581330A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101716194A (en) * | 2008-12-02 | 2010-06-02 | 天津天狮生物发展有限公司 | Multi-flavor chewable calcium tablets and production process thereof |
CN103599546A (en) * | 2013-10-30 | 2014-02-26 | 界首市东亚淀粉出品有限公司 | Renewable calcium tablet filler containing modified starch |
CN103734582A (en) * | 2014-01-23 | 2014-04-23 | 甘南倍益特生物科技有限公司 | Yak lactoprotein polypeptide nutrition powder applicable to middle-aged and aged people and preparation method of powder |
CN105124606A (en) * | 2015-09-07 | 2015-12-09 | 天津市康瑞药业有限公司 | Composite vitamin complementing tablet suitable for middle-aged males and aged males |
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