CN105579849B - 在用于检测多聚靶分子的基于颗粒的测试中防止聚集的试剂、方法和设备 - Google Patents

在用于检测多聚靶分子的基于颗粒的测试中防止聚集的试剂、方法和设备 Download PDF

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Publication number
CN105579849B
CN105579849B CN201480044234.4A CN201480044234A CN105579849B CN 105579849 B CN105579849 B CN 105579849B CN 201480044234 A CN201480044234 A CN 201480044234A CN 105579849 B CN105579849 B CN 105579849B
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epitope
target analyte
capture entity
detection
particle
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Chinese (zh)
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CN105579849A (zh
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T.H.埃维斯
M.W.J.普林斯
J.H.纽文休伊斯
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Siemens Medical Diagnostic Solutions First Holdings Ltd
Siemens Medical Holland Ltd
Siemens Medical Systems Holland Ltd
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Micro Care Private Ltd Co
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201480044234.4A 2013-06-06 2014-06-05 在用于检测多聚靶分子的基于颗粒的测试中防止聚集的试剂、方法和设备 Active CN105579849B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13170722.6 2013-06-06
EP13170722 2013-06-06
PCT/IB2014/061986 WO2014195899A1 (en) 2013-06-06 2014-06-05 Reagents, methods and devices to prevent aggregation in particle based tests for the detection of multimeric target molecules

Publications (2)

Publication Number Publication Date
CN105579849A CN105579849A (zh) 2016-05-11
CN105579849B true CN105579849B (zh) 2019-02-22

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CN201480044234.4A Active CN105579849B (zh) 2013-06-06 2014-06-05 在用于检测多聚靶分子的基于颗粒的测试中防止聚集的试剂、方法和设备

Country Status (5)

Country Link
US (1) US10895571B2 (enExample)
EP (1) EP3004882B1 (enExample)
JP (2) JP2016520846A (enExample)
CN (1) CN105579849B (enExample)
WO (1) WO2014195899A1 (enExample)

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ES2761427T3 (es) 2014-12-18 2020-05-19 Hoffmann La Roche Procedimientos para reducir interferencias
CN109416357B (zh) * 2016-06-30 2022-07-15 西门子医疗系统荷兰有限公司 用于检测包含多个细胞的体液样本中的分析物的设备、系统和方法
EP3529617B1 (en) * 2016-10-24 2023-05-17 Roche Diagnostics GmbH Immobilized analytes
CN111615632A (zh) * 2017-08-26 2020-09-01 Aj耶拿检疫有限公司 借助于大颗粒粒子检测分析物的器件和方法
WO2020141463A2 (en) * 2019-01-03 2020-07-09 Pixcell Medical Technologies Ltd. Systems and methods for analyzing a fluid sample
US12000828B2 (en) 2019-03-25 2024-06-04 Boe Technology Group Co., Ltd. Immunodetection chip, immunodetection device and using method
FR3100338B1 (fr) * 2019-08-30 2022-09-02 Centre Nat Rech Scient Kit et méthode de capture d’une molécule
CN118043667A (zh) * 2021-10-08 2024-05-14 菲利普莫里斯生产公司 周围介质中的生物活性剂的检测

Citations (3)

* Cited by examiner, † Cited by third party
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CN1646913A (zh) * 2002-04-10 2005-07-27 反应生物医学公司 敏感性免疫色原图像测试
CN101438163A (zh) * 2006-05-09 2009-05-20 皇家飞利浦电子股份有限公司 利用磁场检测样品中的靶分子
WO2013072877A1 (en) * 2011-11-16 2013-05-23 Koninklijke Philips Electronics N.V. Particle repulsion to enhance surface contact in magnetic particle immunoassays

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AU3474100A (en) * 1999-01-25 2000-08-07 Minerva Biotechnologies Corporation Rapid and sensitive detection of aberrant protein aggregation in neurodegenerative diseases
US20010049111A1 (en) * 1999-08-13 2001-12-06 Norbert Windhab Methods, procedures, and formats for using microelectronic array devices to perform multiplex immunoassay analyses
US6680209B1 (en) * 1999-12-06 2004-01-20 Biosite, Incorporated Human antibodies as diagnostic reagents
ES2629832T3 (es) * 2006-02-08 2017-08-16 Becton Dickinson And Company Ensayos con nanoetiquetas SERS
US20080138842A1 (en) * 2006-12-11 2008-06-12 Hans Boehringer Indirect lateral flow sandwich assay
CN104764724A (zh) 2006-12-12 2015-07-08 皇家飞利浦电子股份有限公司 用于检测标记颗粒的微电子传感器装置
WO2008083323A1 (en) * 2006-12-29 2008-07-10 Invitrogen Corporation Detection apparatus
WO2009003142A1 (en) 2007-06-27 2008-12-31 The Board Of Trustees Of The Leland, Stanford Junior University Beta2-microglobulin and c reactive protein (crp) as biomarkers for peripheral artery disease
US9494580B2 (en) * 2008-09-11 2016-11-15 Tokyo Institute Of Technology Polymer particle containing fluorescent molecule and method for producing the same
RU2011142784A (ru) * 2009-03-23 2013-04-27 Конинклейке Филипс Электроникс Н.В. Манипуляция магнитными частицами в биологическом образце
EP2720060A1 (en) 2009-09-28 2014-04-16 Koninklijke Philips N.V. A biosensor system for single particle detection
JP5814806B2 (ja) * 2011-03-30 2015-11-17 株式会社東芝 光導波路型測定システム、測定方法及び光導波路型センサチップ
US8982136B2 (en) * 2011-05-16 2015-03-17 Qualcomm Incorporated Rendering mode selection in graphics processing units
EP2594942A1 (en) 2011-11-16 2013-05-22 Koninklijke Philips Electronics N.V. Long rigid spacers to enhance binding kinetics in immunoassays

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN1646913A (zh) * 2002-04-10 2005-07-27 反应生物医学公司 敏感性免疫色原图像测试
CN101438163A (zh) * 2006-05-09 2009-05-20 皇家飞利浦电子股份有限公司 利用磁场检测样品中的靶分子
WO2013072877A1 (en) * 2011-11-16 2013-05-23 Koninklijke Philips Electronics N.V. Particle repulsion to enhance surface contact in magnetic particle immunoassays

Also Published As

Publication number Publication date
JP6746866B2 (ja) 2020-08-26
EP3004882B1 (en) 2018-03-21
US10895571B2 (en) 2021-01-19
EP3004882A1 (en) 2016-04-13
WO2014195899A1 (en) 2014-12-11
CN105579849A (zh) 2016-05-11
JP2019060873A (ja) 2019-04-18
US20160123965A1 (en) 2016-05-05
JP2016520846A (ja) 2016-07-14

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