CN105571930B - A kind of sputum liquefies instrument and its sputum liquefaction method automatically - Google Patents
A kind of sputum liquefies instrument and its sputum liquefaction method automatically Download PDFInfo
- Publication number
- CN105571930B CN105571930B CN201610034008.9A CN201610034008A CN105571930B CN 105571930 B CN105571930 B CN 105571930B CN 201610034008 A CN201610034008 A CN 201610034008A CN 105571930 B CN105571930 B CN 105571930B
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- sputum
- test tube
- liquefaction
- pipettor
- sample
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
Abstract
It liquefies automatically instrument and its sputum liquefaction method the invention discloses a kind of sputum.This sputum liquefies instrument and its sputum liquefaction method automatically, the moving arm and mechanical arm being equipped with are when in use, pass through the mobile pipettor of moving arm, carry out drawing liquid is moved up and down by mechanical arm, liquid and piping and druming mix out, realize the automation liquefaction of sputum, the automatic subpackaging of Sputum culturing automation sample-adding and sputum liquefaction liquid, 16 sputum samples can be handled in sputum automation liquefaction instrument 30min, working efficiency is greatly improved, with automatic operation, flux processing, it is easy to operate, it is easy to use, the advantages that sample room no cross contamination, directly contact be can avoid to reduce the probability of personnel's infection and sample cross contamination, it realizes quick, it is economical, easy sputum handles work.Meet the urgent primary demand of clinical detection mechanism.The present invention is suitable for medical instruments field.
Description
Technical field
The present invention relates to medical instruments field, liquefy automatically instrument and its sputum liquefaction method more particularly to a kind of sputum.
Background technique
Currently, deepening continuously with tubercle bacillus diagnosis and detection technique and theoretical research, sample preparation at
Where bottleneck to restrict its development.Because of the particularity of sputum, the culture of mycobacterium tuberculosis and detection of nucleic acids are necessary in sputum
It is handled by liquefaction, in the detection of traditional mycobacterium tuberculosis, that there are detection efficiencies is low for manual operation, the operating time is long,
Inhomogenous etc. the deficiency of sample cross contamination, sample process, not only needs to spend a large amount of human and material resources, financial resources, and
Testing result is unstable, can not meet increasingly increased patient's sample and detection demand, greatly reduces tuberculosis and make a definite diagnosis efficiency,
And medical worker must directly contact sample, may cause infection and cause personal injury.It would therefore be highly desirable to which a kind of safely and effectively set
It is standby.
Summary of the invention
To solve the above problems, the present invention provides a kind of raising detection efficiency, guarantees analysis quality and protection medical matters people
The sputum of member's safety liquefies instrument and its sputum liquefaction method automatically.
The technical solution adopted by the present invention to solve the technical problems is:
A kind of sputum liquefies instrument, including at least one set of sputum liquefaction test tube group automatically, is equipped with and moves in sputum liquefaction test tube group
Liquid device, pipettor top are equipped with the moving arm for moving pipettor and the mechanical arm for blowing and beating mixing.
It is further used as the improvement of technical solution of the present invention, and sputum liquefaction test tube group is including at least one set of base set and at least
One kit, each base set include the sputum sample test tube set gradually, pipettor placement pipe, culture medium test tube, centrifuge tube, are moved
Liquid device, which is placed, places pipettor in pipe.
It is further used as the improvement of technical solution of the present invention, and the NaOH solution that mass percent is 4% is held in kit,
Improvement type Russell medium is held in culture medium test tube.
It is further used as the improvement of technical solution of the present invention, and sputum liquefaction test tube group is fixed in specimen holder, and sample is set up
It sets on specimen holder carrying sliding stand, specimen holder carrying sliding stand two sides are equipped with the spring for fixing specimen holder carrying sliding stand
Pulling pin.
It is further used as the improvement of technical solution of the present invention, and sputum liquefaction test tube group, moving arm and mechanical arm are externally provided with shell
Body, the interior chlorination equipment being equipped with for disinfection of shell.
It is further used as the improvement of technical solution of the present invention, and chlorination equipment is ultraviolet lamp, and pipettor is disposable syringe.
It is further used as the improvement of technical solution of the present invention, and shell is additionally provided with lid, and support is equipped between shell and lid
Bar.
It is further used as the improvement of technical solution of the present invention, and touch screen is additionally provided on shell, the shuttle for standby operation
Key, power interface, power switch, pedestal key, device state indicator lamp.
A kind of sputum liquefaction method for the instrument that liquefied automatically by sputum, comprising the following steps:
A. place in sputum liquefaction test tube group includes having collected sputum sample, culture medium, reagent；
B. sputum liquefaction is carried out by liquid in the mobile sputum liquefaction test tube group of the mobile pipettor of moving arm；
C. liquid in the sputum liquefaction test tube group that piping and druming mixes is moved up and down by mechanical arm.
It is further used as the improvement of technical solution of the present invention, and in step A, sputum liquefaction test tube group includes at least one set of basis
Group and at least one kit, be sequentially placed in base set sputum sample test tube for placing sputum sample, pipettor, culture medium test tube,
Centrifuge tube, in use, extracting the reagent in kit for reagent movement by the mobile pipettor of moving arm, and by mechanical arm
To sputum sample test tube, the liquid in sputum sample test tube is then moved to culture medium test tube and mixing is blown and beaten by mechanical arm, finally will
Culture medium test tube is moved to centrifuge tube.
Beneficial effects of the present invention: this sputum liquefies instrument and its sputum liquefaction method automatically, the moving arm and machinery being equipped with
Arm when in use, by the mobile pipettor of moving arm, is moved up and down by mechanical arm and carries out drawing liquid, goes out liquid and piping and druming mixing,
Realize that the automation liquefaction of sputum, Sputum culturing automation is loaded and the automatic subpackaging of sputum liquefaction liquid, sputum automation liquefaction instrument
16 sputum samples can be handled in 30min, and working efficiency is greatly improved, and there is automatic operation, flux to handle, is easy to operate,
The advantages that easy to use, sample room no cross contamination, can avoid directly contact to reduce personnel's infection and sample cross contamination
Probability, realize that sputum quickly, economic, easy handles work.Meet the urgent primary demand of clinical detection mechanism.
Detailed description of the invention
The present invention will be further explained below with reference to the attached drawings:
Fig. 1 is overall structure diagram of the embodiment of the present invention；
Fig. 2 is the arrangement schematic diagram of sputum liquefaction test tube group described in the embodiment of the present invention.
Specific embodiment
It is carried out below with reference to technical effect of the embodiment and attached drawing to design of the invention, specific structure and generation clear
Chu is fully described by, to be completely understood by the purpose of the present invention, feature and effect.Obviously, described embodiment is this hair
Bright a part of the embodiment, rather than whole embodiments, based on the embodiment of the present invention, those skilled in the art are not being paid
Other embodiments obtained, belong to the scope of protection of the invention under the premise of creative work.
Referring to Fig.1, Fig. 2, the present invention are that a kind of sputum liquefies instrument, including at least one set of sputum liquefaction test tube group automatically, phlegm
Liquid liquefies, and test tube group is interior to be equipped with pipettor 15, is equipped with above pipettor 15 for moving the moving arm of pipettor 15 and for blowing and beating
The mechanical arm of mixing.
This sputum liquefies instrument and its sputum liquefaction method automatically, and the moving arm and mechanical arm being equipped with when in use, pass through shifting
Swing arm moves pipettor 15, is moved up and down by mechanical arm and carries out drawing liquid, goes out liquid and piping and druming mixing, realizes the automation of sputum
The automatic subpackaging of liquefaction, Sputum culturing automation sample-adding and sputum liquefaction liquid has automatic operation, flux processing, operation letter
The advantages that single, easy to use, sample room no cross contamination, it is dirty to reduce personnel's infection and sample cross to can avoid directly contact
The probability of dye realizes that sputum quickly, economic, easy handles work.Meet the urgent primary demand of clinical detection mechanism.
As a preferred embodiment of the present invention, sputum liquefaction test tube group include at least one set of base set 1 and at least one
Kit 2, each base set 1 include the sputum sample test tube 11 set gradually, pipettor placement pipe 12, culture medium test tube 13, centrifugation
Pipe 14, pipettor, which is placed, places pipettor 15 in pipe 12.
As a preferred embodiment of the present invention, the NaOH solution that mass percent is 4%, culture medium are held in kit 2
Improvement type Russell medium is held in test tube 13.
As a preferred embodiment of the present invention, sputum liquefaction test tube group is fixed in specimen holder 58, and specimen holder 58 is arranged
On specimen holder carrying sliding stand 4, specimen holder carrying 4 two sides of sliding stand are equipped with the bullet for fixing specimen holder carrying sliding stand 4
Spring pulling pin 3.
As a preferred embodiment of the present invention, sputum liquefaction test tube group, moving arm and mechanical arm are externally provided with shell 5, shell
The chlorination equipment for disinfection is equipped in body 5.
As a preferred embodiment of the present invention, chlorination equipment is ultraviolet lamp 53, and pipettor 15 is disposable syringe.
As a preferred embodiment of the present invention, shell 5 is additionally provided with lid 59, and support is equipped between shell 5 and lid 59
Bar.
As a preferred embodiment of the present invention, it is additionally provided with touch screen 51 on shell 5, the shuttle key for standby operation
52, power interface 54, power switch 55, pedestal key 56, device state indicator lamp 57.
A kind of sputum liquefaction method for the instrument that liquefied automatically by sputum, comprising the following steps:
A. place in sputum liquefaction test tube group includes having collected sputum sample, culture medium, reagent；
B. sputum liquefaction is carried out by liquid in the mobile sputum liquefaction test tube group of the mobile pipettor 15 of moving arm；
C. liquid in the sputum liquefaction test tube group that piping and druming mixes is moved up and down by mechanical arm.
As a preferred embodiment of the present invention, in step A, sputum liquefaction test tube group include at least one set of base set 1 and
At least one kit 2 is sequentially placed sputum sample test tube 11, pipettor 15, culture medium test tube for placing sputum sample in base set 1
13, centrifuge tube 14, in use, by the mobile pipettor 15 of moving arm, and extracting the reagent in kit 2 by mechanical arm will
Reagent is moved to sputum sample test tube 11, and the liquid in sputum sample test tube 11 is then moved to culture medium test tube 13 and is blown by mechanical arm
It beats and mixes, culture medium test tube 13 is finally moved to centrifuge tube 14.
This sputum liquefies instrument combination electromechanical automatic and integrated technique, it can be achieved that at the automation liquefaction of sputum sample automatically
Reason and automation inoculated and cultured；Using automatic control system, it can be achieved that high accuracy positioning control, speed control, self adaptive control,
Self diagnosis correction, compensation.This sputum liquefies the avoidable directly contact of instrument automatically to reduce personnel's infection and sample cross contamination
Probability, realize that sputum quickly, economic, easy handles work.
This sputum instrument that liquefies automatically for committed steps such as the cultures of sputum liquefaction, mycobacterium tuberculosis provides automatic processing
Scheme, the Automation workstation developed have the advantage that
Integration, multi-functional: automatic sputum liquefaction processing system includes tuberculosis branch in sputum automation liquefaction and sputum
The inoculated and cultured of bacillus, it is not only that sputum liquefaction is integrated with inoculated and cultured, while sputum liquefaction liquid can be used for nucleic acid extraction etc.
Other purposes.
Flux, high efficiency: can handle 16 sputum samples in sputum automation liquefaction instrument 30min, artificial treatment about 2 small
When, working efficiency is greatly improved；Automatic liquefaction processing, the Sputum culturing automatic sample, sputum liquefaction of 16 portions of sputums can be achieved at the same time
Liquid automatic subpackaging.
Prevention infection: automation instead of having safety precaution setting while manual operation, reduces medical staff infection wind
Danger；Measure and corresponding design with prevention and control pollution, can avoid because of liquefaction movement excessively fierceness, mechanical part movement, liquid relief etc.
Sample cross contamination caused by the process；Realize monocyte sample closed system operation: the mating consumption such as sputum liquefaction bottle, sputum culture bottle
Material should have the design of anti-cross-contamination.
Standardization, accuracy are high: automatic processing not only reduces error brought by manual operation, while improving detection
As a result homogeneity and accuracy.Automatic sputum liquefaction processing system mainly have sample processing system, software operation control system,
The critical systems such as mating consumptive material or module composition, sample processing system refer mainly to realize the various mechanical devices of automatic operation,
Software operation control system includes program and operation interface needed for completing operations, and mating consumptive material includes to realize automatic sputum
The mating consumptive materials such as special sputum bottle, Sputum culturing bottle needed for the processing system that liquefies.Treatment process includes automatic liquid-feeding, blows and beats and mix
Even, automatic liquid relief, sputum culture automatic sample, sputum liquefaction liquid automatic subpackaging and etc., and above step can as needed certainly
Row selection, especially Sputum culturing automatic sample, sputum liquefaction liquid automatic subpackaging can be selected voluntarily as needed.
With UV germicidal system, the ultraviolet opening time can be set, can voluntarily close ultraviolet lamp after time arrival.Equipment work
Independent outer cover need to be had by making region, and guarantee operator is isolated with sample.Operation interface is touch screens (button adds touch screen),
It specific interface need to be in conjunction with the actual demand of clinical detection unit, it is desirable that interface hommization, easy to operate, smoothization.
The preferred embodiment of the present invention, including specimen holder 58, sample rack volume size is suitable, contains 8 sputum liquefaction liquid examinations
Pond is stored in agent, and 16 Sputum samples handle receiving hole, 16 sputum culture bottle receiving hole, and 16 liquefiers dispense pipe receiving hole,
Each receiving hole is matched with standard configuration consumptive material (can be general with common consumptive material in the market), and space layout is reasonable.
The sputum liquefaction instrument, main display and operation interface are touch screens, and general user is by clicking touch screen
Upper corresponding control, to operate the instrument.Machine can not operate when touch screen failure in order to prevent, and in addition there are also shuttle keys to make
For standby operation mode.The automatic subpackaging for automating liquefaction, Sputum culturing automation sample-adding and sputum liquefaction liquid of sputum is realized,
Handle with automatic operation, flux and (realize the automatic processing of 16 sputums in 30min), is easy to operate, easy to use,
The advantages that sample room no cross contamination, not only meets the urgent primary demand of clinical detection mechanism, while cheap, is suitable for
Base promotes.
Certainly, the invention is not limited to above embodiment, and those skilled in the art are without prejudice to originally
Equivalent deformation or replacement can be also made under the premise of spirit, these equivalent deformations or replacement are all contained in the application right
It is required that in limited range.
Claims (4)
- The instrument 1. a kind of sputum liquefies automatically, it is characterised in that: including at least one set of sputum liquefaction test tube group, the sputum liquefaction examination Pipettor (15) are equipped in pipe group, are equipped with above the pipettor (15) for moving the moving arm of pipettor (15) and for blowing Beat the mechanical arm mixed；The sputum liquefaction test tube group includes at least one set of base set (1) and at least one kit (2), respectively The base set (1) include set gradually sputum sample test tube (11), pipettor place pipe (12), culture medium test tube (13), from Heart pipe (14), the pipettor are placed in pipe (12) and place pipettor (15), and the sputum liquefaction test tube group is fixed on specimen holder (58) in, in specimen holder carrying sliding stand (4), the specimen holder carries sliding stand (4) two sides for specimen holder (58) setting Equipped with the spring pulling pin (3) for fixing specimen holder carrying sliding stand (4), the sputum liquefaction test tube group, moving arm and machinery Arm is externally provided with shell (5), and the chlorination equipment for disinfection is equipped in the shell (5), and the shell (5) is additionally provided with lid (59), support rod is equipped between the shell (5) and lid (59), the chlorination equipment is ultraviolet lamp (53), the pipettor It (15) is disposable syringe.
- The instrument 2. sputum according to claim 1 liquefies automatically, it is characterised in that: hold quality hundred in the kit (2) Divide the NaOH solution than being 4%, holds Improvement type Russell medium in the culture medium test tube (13).
- The instrument 3. sputum according to claim 1 liquefies automatically, it is characterised in that: be additionally provided with touch screen on the shell (5) (51), for the shuttle key (52) of standby operation, power interface (54), power switch (55), pedestal key (56), equipment shape State indicator light (57).
- 4. a kind of liquefied the sputum liquefaction method of instrument automatically by sputum described in claim 1, which is characterized in that including following Step:A. placing in sputum liquefaction test tube group includes having collected sputum sample, culture medium, reagent, and the sputum liquefaction test tube group includes At least one set of base set (1) and at least one kit (2), the interior phlegm being sequentially placed for placing sputum sample of the base set (1) Sample test tube (11), pipettor (15), culture medium test tube (13), centrifuge tube (14), in use, passing through the mobile pipettor of moving arm (15), and the reagent in kit (2) is extracted by mechanical arm and reagent is moved to sputum sample test tube (11), then try sputum sample Liquid in pipe (11) is moved to culture medium test tube (13) and is blown and beaten by mechanical arm and mixed, and finally moves culture medium test tube (13) It moves to centrifuge tube (14)；B. sputum liquefaction is carried out by liquid in the mobile sputum liquefaction test tube group of moving arm mobile pipettor (15)；C. liquid in the sputum liquefaction test tube group that piping and druming mixes is moved up and down by mechanical arm.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610034008.9A CN105571930B (en) | 2016-01-19 | 2016-01-19 | A kind of sputum liquefies instrument and its sputum liquefaction method automatically |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610034008.9A CN105571930B (en) | 2016-01-19 | 2016-01-19 | A kind of sputum liquefies instrument and its sputum liquefaction method automatically |
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| CN105571930A CN105571930A (en) | 2016-05-11 |
| CN105571930B true CN105571930B (en) | 2019-05-07 |
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| CN109900539B (en) * | 2019-03-15 | 2021-07-20 | 遵义医学院附属医院 | Bionic reagent batch adding and mixing device for HPV detection experiment |
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| CN103558071A (en) * | 2013-11-08 | 2014-02-05 | 上海微银生物技术有限公司 | Full-automatic phlegm specimen smearing instrument, system and method |
| WO2014150290A1 (en) * | 2013-03-15 | 2014-09-25 | Theranos, Inc. | Devices, systems and methods for sample preparation |
| CN104459174A (en) * | 2014-12-24 | 2015-03-25 | 山东诺安诺泰信息系统有限公司 | Portable type full-automatic biochemical analyzer |
| CN105170210A (en) * | 2015-10-14 | 2015-12-23 | 东南大学 | Multi-channel liquid transfer device |
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- 2016-01-19 CN CN201610034008.9A patent/CN105571930B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102243243A (en) * | 2010-05-13 | 2011-11-16 | 南京神州英诺华医疗科技有限公司 | Novel instrument for automatically processing phlegm sample |
| CN102375069A (en) * | 2010-08-26 | 2012-03-14 | 南京神州英诺华医疗科技有限公司 | Novel automatic treatment instrument for respiratory tract specimen |
| WO2014150290A1 (en) * | 2013-03-15 | 2014-09-25 | Theranos, Inc. | Devices, systems and methods for sample preparation |
| CN103558071A (en) * | 2013-11-08 | 2014-02-05 | 上海微银生物技术有限公司 | Full-automatic phlegm specimen smearing instrument, system and method |
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| CN105571930A (en) | 2016-05-11 |
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Denomination of invention: An automatic sputum liquefying instrument and its sputum liquefying method Effective date of registration: 20210318 Granted publication date: 20190507 Pledgee: China Co. truction Bank Corp Guangzhou Tianhe subbranch Pledgor: GUANGZHOU DEAOU BIOTECHNOLOGY Co.,Ltd. Registration number: Y2021440000083 |
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Date of cancellation: 20221031 Granted publication date: 20190507 Pledgee: China Co. truction Bank Corp Guangzhou Tianhe subbranch Pledgor: GUANGZHOU DEAOU BIOTECHNOLOGY Co.,Ltd. Registration number: Y2021440000083 |