CN105571929A - Sample and reagent mixing system and mixing method - Google Patents
Sample and reagent mixing system and mixing method Download PDFInfo
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- CN105571929A CN105571929A CN201510750794.8A CN201510750794A CN105571929A CN 105571929 A CN105571929 A CN 105571929A CN 201510750794 A CN201510750794 A CN 201510750794A CN 105571929 A CN105571929 A CN 105571929A
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Abstract
The invention discloses a sample and reagent mixing system and a sample and reagent mixing method. The sample and reagent mixing system comprises a rotating device, reaction vessels, a cover device and a controller. The rotating device comprises a rotating disc which is used for hanging the reaction vessels rotationally. The cover device can cover the reaction vessels hung on the rotating disc. Each reaction vessel comprises a sample vessel and a reagent vessel, and an opening of the sample vessel can be in sealed connection with an opening of the reagent vessel. The reagent vessel is provided with four reagent vessel units respectively containing a first reagent, a second reagent, a third reagent and a fourth reagent in advance, and is provided with a disc-like partition with four round holes; each round hole serves as an opening of each reagent vessel unit; and the opening of each reagent vessel unit is provided with a lid and a sealing film. By application of the sample and reagent mixing system and the mixing method, users do not need to add reagents extra, operation is facilitated, and errors are reduced.
Description
Technical field
The present invention relates to medical instruments field, be specifically related to a kind of sample reagent commingled system and mixed method.
Background technology
Sample analysis is the common analysis of medical field, utilize pick-up unit to pattern detection before usually need sample to be tested to mix with reagent, and the project of sample analysis is a lot, and different analysis projects relates to and adds different reagent, operation is comparatively complicated, easily makes mistakes.Along with the progress of technology, equipment simple to operate constantly occurs, but sometimes can't meet the needs of use.
Summary of the invention
Goal of the invention: the present invention is intended to the defect overcoming prior art, provides a kind of sample reagent commingled system and mixed method.
Technical scheme: a kind of sample reagent commingled system, comprises whirligig, reaction vessel, shrouds device and controls whirligig, shrouds the controller of device;
Described whirligig comprises base plate, the column be arranged on base plate, the motor being arranged on column top, the armature be arranged on motor output shaft, described armature lower surface is provided with a circle hook, described hook is for hanging reaction vessel, and described motor drives armature to rotate;
The described cover portion shrouded device and comprise many shutdown mechanical arms and be arranged on multi-joint mechanical arm end, described cover portion is the cylinder annular of upper and lower opening, and the cover portion that the reaction vessel that armature is hung all can be covered on cylinder annular is inner;
Described reaction vessel comprises the columniform transparent sample container with opening and the columniform reagent container with opening, and the chamber wall of the chamber wall of the close opening of described sample container and the close opening of reagent container has the screw thread that cooperatively interacts for the opening of sample container and the opening of reagent container being tightly connected; Described sample container is used for splendid attire sample to be tested, and described reagent container is used for splendid attire reagent; Be provided with 4 sub-reagent containers in described reagent container and be preinstalled with the first reagent, the second reagent, the 3rd reagent and the 4th reagent respectively; Described reagent container is provided with the circular separating part of sheet, described separating part is provided with 4 circular holes, each described circular hole forms the opening of 1 sub-container, and the space between the chamber wall of reagent container and the chamber wall of 4 sub-reagent containers is hedged off from the outer world by described separating part; The opening part of described every sub-reagent container is provided with cap, for sub-reagent container is sealed, every sub-reagent container is also provided with and is positioned at diaphragm seal inside cap for the reagent of prepackage is sealed in sub-reagent container, and described diaphragm seal can break when external force mobile reagent container; The outside surface of the cap of described sub-reagent container is also provided with the corresponding identification marking of the types of agents pre-installed in reagent container with this; The bottom of described reagent container is also provided with semicircle ring portion, and reaction vessel is hung over armature for coordinating described hook by described semicircle ring portion.
Further, the sub-reagent container of described reagent container and its inside is made by transparent material.
Further, the wall of described separating part and reagent container and the wall of sub-reagent container one-body molded.
Further, described separating part is arranged near reagent container opening part, distance edge of opening 0.5-1cm.
Further, described diaphragm seal is circular, is made up of the diaphragm seal of two semicircles, and between the diaphragm seal of two semicircles, rosin joint connects.
Further, the hook of described armature is 6, is evenly arranged a circle.
Further, in every sub-reagent container, the volume of pre-filled reagent liquid is no more than 3/4 of sub-reagent container volume.
Use a sample reagent mixed method for above-mentioned sample reagent commingled system, it is characterized in that comprising the steps:
1) one or more reaction vessel is got, according to the test item detected needed for sample in each sample container, after the cap of the one or more sub-container in the reagent container corresponding with this sample container is opened, each sample container is tightly connected with corresponding reagent container;
2) hang on the hook of armature by each reaction vessel, utilize motor to drive armature to rotate, the diaphragm seal of the sub-reagent container that the cap in each reagent container is opened breaks;
3) controller control motor stops the rotation;
4) controller controls, and utilization is shrouded device and covered by all reaction vessels on armature;
5) drive motor rotates reagent and sample mixing.
Further, step 5) rotation process be reciprocating rotary operation.
Further, step 5) rotation process comprise at least twice accelerated motion and at least twice retarded motion.
Beneficial effect: commingled system of the present invention is easy to use, reaction vessel in coupled system, operator does not need additionally to find reagent, only need open according to the lid of required analysis project by required reagent, and reaction vessel is hung on armature, and easy to use, be not easy to make mistakes, because reagent is sealed in sub-reagent container, be not easy to go bad.
Accompanying drawing explanation
Fig. 1 is reaction vessel schematic diagram;
Fig. 2 is that reagent container is from its peristome viewing schematic diagram;
Fig. 3 reagent container is from its peristome other end viewing schematic diagram;
Fig. 4 is diaphragm seal schematic diagram;
Fig. 5 is commingled system schematic diagram;
Fig. 6 is armature lower surface schematic diagram;
Fig. 7 is cover portion schematic top plan view;
Fig. 8 is whirligig schematic diagram;
Fig. 9 covers reaction vessel schematic diagram for shrouding device.
Embodiment
Reference numeral: 1 first sub-reagent container; 2 second sub-reagent containers; 3 the 3rd sub-reagent containers; 4 the 4th sub-reagent containers; 5 reagent containers; 6 sample container; The diaphragm seal of 1.1 first sub-reagent containers; The diaphragm seal of 2.1 second sub-reagent containers; The diaphragm seal of 3.1 the 3rd sub-reagent containers; The diaphragm seal of 4.1 the 4th sub-reagent containers; The cap of 1.2 first sub-reagent containers; The cap of 2.2 second sub-reagent containers; The cap of 3.2 the 3rd sub-reagent containers; The cap of 4.2 the 4th sub-reagent containers; 5.1 separating part; 5.2 semicircle ring portions; 1.1.1 the rosin joint place of the diaphragm seal of the first sub-reagent container; 2.1.1 the rosin joint place of the diaphragm seal of the second sub-reagent container; 3.1.1 the rosin joint place of the diaphragm seal of the 3rd sub-reagent container; 4.1.1 the rosin joint place of the diaphragm seal of the 4th sub-reagent container; 11 base plates; 12 columns; 13 rotating circular disks; 13.1 hooks; 14.1 multi-joint mechanical arms; 14.2 cover portion; 15 motors.
Illustrate below in conjunction with accompanying drawing:
A kind of sample reagent commingled system, comprises whirligig, reaction vessel, shrouds device and controls whirligig, shrouds the controller of device; Described whirligig comprises base plate 11, the column 12 be arranged on base plate, the motor 15 being arranged on column top, the armature 13 be arranged on motor output shaft, described armature lower surface is provided with a circle hook 13.1, described hook is for hanging reaction vessel, and described motor drives armature to rotate; The described cover portion 14.2 shrouded device and comprise many shutdown mechanical arms 14.1 and be arranged on multi-joint mechanical arm end, described cover portion is that (both upper and lower opening was cylindrical for the cylinder annular of upper and lower opening, inside is empty, cross section), the cover portion that the reaction vessel that armature is hung all can be covered on cylinder annular is inner; Described reaction vessel comprises the columniform transparent sample container with opening and the columniform reagent container with opening, and the chamber wall of described sample container and the chamber wall of reagent container have the screw thread that cooperatively interacts for the opening of sample container and the opening of reagent container being tightly connected; Described sample container is used for splendid attire sample to be tested, and described reagent container is used for splendid attire reagent; Be provided with 4 sub-reagent containers 1,2,3,4 in described reagent container and be preinstalled with the first reagent, the second reagent, the 3rd reagent and the 4th reagent respectively; Described reagent container is provided with the circular separating part of sheet, described separating part is provided with 4 circular holes, each described circular hole forms the opening of 1 sub-container, and the space between the chamber wall of reagent container and the chamber wall of 4 sub-reagent containers is hedged off from the outer world by described separating part; The opening part of described every sub-reagent container is provided with cap 1.2,2.2,3.2,4.2, for sub-reagent container is sealed, every sub-reagent container is also provided with and is positioned at diaphragm seal 1.1,2.1,3.1,4.1 inside cap for the reagent of prepackage is sealed in sub-reagent container, breaks described diaphragm seal can move (rocking) reagent container during in external force; The outside surface of the cap of described sub-reagent container is also provided with the corresponding identification marking of the types of agents pre-installed in reagent container with this; The bottom of described reagent container is also provided with semicircle ring portion, and reaction vessel is hung over armature 13 for coordinating described hook by described semicircle ring portion.
Identification marking is such as Chinese character or arabic numeral, as long as operator can distinguish reagent type.Distance between diaphragm seal and cap can be very little, such as 0.2-0.3cm.In every sub-reagent container, the volume of pre-filled reagent liquid is no more than 3/4 of sub-reagent container volume.Owing to not having technical term, separating part also can be referred to as catch.The hook of described armature is 6, is evenly arranged a circle.
The sub-reagent container of reagent container and its inside is made by transparent material, 4 sub-reagent containers and respective cap threadedly seal, the wall of separating part and reagent container and the wall of sub-reagent container one-body molded, separating part can be arranged near reagent container opening part, such as distance edge of opening 1cm.Diaphragm seal is circular, is made up of the diaphragm seal of two semicircles, and between the diaphragm seal of two semicircles, rosin joint connects.When movement (or rocking) reagent container, because diaphragm seal is fragile, be easy to break under the impact of therefore pre-filled reagent liquid therein, thus enter sample container and mix with sample; Those are had to the sub-reagent container of cap covers, because cap has certain supporting role to diaphragm seal, even if the reagent solution of its inside impacts diaphragm seal, diaphragm seal is also not easy to break, even and if broken, the reagent solution partes tegmentalis of the inside stops also can not enter sample container, can not bring harmful effect to detection.
For same sample, the test item that may carry out is a lot, and different test items reagent used is different, and Cleaning Principle is also different.Such as project one, need reagent one, Cleaning Principle is test absorbance; For project two, need reagent two, Cleaning Principle is spectral measurement, etc.Certainly, diaphragm seal also can be exactly the more fragile diaphragm seal of whole piece circle, as long as can break under External Force Acting.
Use a sample reagent mixed method for above-mentioned sample reagent commingled system, it is characterized in that comprising the steps:
1) one or more reaction vessel is got, according to the test item detected needed for sample in each sample container, after the cap of the one or more sub-container in the reagent container corresponding with this sample container is opened, each sample container is tightly connected with corresponding reagent container;
2) hang on the hook of armature by each reaction vessel, utilize motor to drive armature to rotate, the diaphragm seal of the sub-reagent container that the cap in each reagent container is opened breaks;
3) controller control motor stops the rotation;
4) controller controls, and utilization is shrouded device and covered by all reaction vessels on armature;
5) drive motor rotates reagent and sample mixing.
In order to the Blending Efficiency of Blending obtained, step 5) rotation process be reciprocating rotary operation, also can step 5) rotation process comprise at least twice accelerated motion and at least twice retarded motion.Also can be other irregular rotary motions.
The principle of present system is as follows: step 2) rotation in, rotational speed is very fast, reaction vessel can vertically hang state trend in level from original due to centrifugal action, now the reagent solution of sub-reagent container inside can impact diaphragm seal due to centrifugal action thus diaphragm seal is broken, reagent enters sample and mixes, although now can mixing sample and reagent, due to centrifugal action, the easy layering of mixed liquor, mixed effect is bad.In addition, for the observation needing the diaphragm seal that breaks whether to break not need specially and judgement, due to the fragility of diaphragm seal, as long as centrifugal force acquires a certain degree, diaphragm seal will inevitably break.In step 5) rotation in, owing to there being the restriction in cover portion, reaction vessel is in plumbness substantially, and adds irregular motion, and centrifugal force is less, can obtain better mixed effect, and mixed effect is similar rocks reaction vessel brokenly.Although step 5) rotation process in, the outer wall of reaction vessel can rub the inwall in cover portion, and due to the outer wall of reaction vessel and inwall all smoother in cover portion, and rotational speed is little, therefore can not produce too many harmful effect.
Although the present invention illustrates with regard to preferred implementation and describes, only it will be understood by those of skill in the art that otherwise exceed claim limited range of the present invention, variations and modifications can be carried out to the present invention.
Claims (9)
1. a sample reagent commingled system, is characterized in that, comprises whirligig, reaction vessel, shrouds device and controls whirligig, shrouds the controller of device;
Described whirligig comprises base plate, the column be arranged on base plate, the motor being arranged on column top, the armature be arranged on motor output shaft, described armature lower surface is provided with a circle hook, described hook is for hanging reaction vessel, and described motor drives armature to rotate;
The described cover portion shrouded device and comprise many shutdown mechanical arms and be arranged on multi-joint mechanical arm end, described cover portion is the cylinder annular of upper and lower opening, and the cover portion that the reaction vessel that armature is hung all can be covered on cylinder annular is inner;
Described reaction vessel comprises the columniform transparent sample container with opening and the columniform reagent container with opening, and the chamber wall of described sample container and the chamber wall of reagent container have the screw thread that cooperatively interacts for the opening of sample container and the opening of reagent container being tightly connected; Described sample container is used for splendid attire sample to be tested, and described reagent container is used for splendid attire reagent; Be provided with 4 sub-reagent containers in described reagent container and be preinstalled with the first reagent, the second reagent, the 3rd reagent and the 4th reagent respectively; Described reagent container is provided with the circular separating part of sheet, described separating part is provided with 4 circular holes, each described circular hole forms the opening of 1 sub-container, and the space between the chamber wall of reagent container and the chamber wall of 4 sub-reagent containers is hedged off from the outer world by described separating part; The opening part of described every sub-reagent container is provided with cap, for sub-reagent container is sealed, every sub-reagent container is also provided with and is positioned at diaphragm seal inside cap for the reagent of prepackage is sealed in sub-reagent container, and described diaphragm seal can break when external force mobile reagent container; The outside surface of the cap of described sub-reagent container is also provided with the corresponding identification marking of the types of agents pre-installed in reagent container with this; The bottom of described reagent container is also provided with semicircle ring portion, and reaction vessel is hung over armature for coordinating described hook by described semicircle ring portion.
2. sample reagent commingled system according to claim 1, is characterized in that, the sub-reagent container of described reagent container and its inside is made by transparent material.
3. sample reagent commingled system according to claim 1, is characterized in that, the wall of described separating part and reagent container and the wall of sub-reagent container one-body molded.
4. sample reagent commingled system according to claim 1, is characterized in that, described separating part is arranged near reagent container opening part, distance edge of opening 0.5-1cm.
5. sample reagent commingled system according to claim 1, is characterized in that, described diaphragm seal is circular, is made up of the diaphragm seal of two semicircles, and between the diaphragm seal of two semicircles, rosin joint connects.
6. sample reagent commingled system according to claim 1, is characterized in that, the hook of described armature is 6, is evenly arranged a circle.
7. use a sample reagent mixed method for the sample reagent commingled system described in any one of claim 1-6, it is characterized in that comprising the steps:
1) one or more reaction vessel is got, according to the test item detected needed for sample in each sample container, after the cap of the one or more sub-container in the reagent container corresponding with this sample container is opened, each sample container is tightly connected with corresponding reagent container;
2) hang on the hook of armature by each reaction vessel, utilize motor to drive armature to rotate, the diaphragm seal of the sub-reagent container that the cap in each reagent container is opened breaks;
3) controller control motor stops the rotation;
4) controller controls, and utilization is shrouded device and covered by all reaction vessels on armature;
5) drive motor rotates reagent and sample mixing.
8. mixed method according to claim 7, is characterized in that, step 5) rotation process be reciprocating rotary operation.
9. mixed method according to claim 7, is characterized in that, step 5) rotation process comprise at least twice accelerated motion and at least twice retarded motion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510750794.8A CN105571929A (en) | 2015-11-06 | 2015-11-06 | Sample and reagent mixing system and mixing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510750794.8A CN105571929A (en) | 2015-11-06 | 2015-11-06 | Sample and reagent mixing system and mixing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105571929A true CN105571929A (en) | 2016-05-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510750794.8A Withdrawn CN105571929A (en) | 2015-11-06 | 2015-11-06 | Sample and reagent mixing system and mixing method |
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| Country | Link |
|---|---|
| CN (1) | CN105571929A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017114246A1 (en) * | 2015-12-29 | 2017-07-06 | 胡绍勤 | Infusion container |
-
2015
- 2015-11-06 CN CN201510750794.8A patent/CN105571929A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017114246A1 (en) * | 2015-12-29 | 2017-07-06 | 胡绍勤 | Infusion container |
| WO2017114247A1 (en) * | 2015-12-29 | 2017-07-06 | 胡绍勤 | Infusion container |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160511 |
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| WW01 | Invention patent application withdrawn after publication |