CN105561017A - 一种用于治疗原发性痛经的中药 - Google Patents
一种用于治疗原发性痛经的中药 Download PDFInfo
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Abstract
本发明涉及一种用于治疗原发性痛经的中药，它是由以下重量配比的原料药材制备而成：肉穗草15份、人面子5份、三股筋9份、太平莓18份、千解草12份、耳草10份、看麦娘15份、粉萆6份。临床实验证明，本发明能够安全有效治疗原发性痛经。
Description
技术领域
本发明涉及一种中药，具体涉及一种用于治疗原发性痛经的中药。
背景技术
原发性痛经即功能性痛经。痛经是指月经期疼痛，常呈痉挛性，集中在下腹部，其他症状包括头痛、乏力、头晕、恶心、呕吐、腹泻、腰腿痛。是年轻女性十分常见的病症。原发性痛经不伴有明显的盆腔器质性疾病。
原发性痛经常发生在年轻女性，原发性病经的发生除体质、精神因素外，主要与病人分泌期子宫内膜内前列腺素(PG)F2α含量过高有关。故痛经经常发生在有排卵的月经周期。PGF2α是在孕激素作用下的分泌期子宫内膜内合成，其受体在子宫肌壁，月经期子宫内膜破碎，PGF2α即被释放出来，刺激子宫肌肉强烈收缩，使子宫内压力增高，局部血流量减少，缺血、缺氧，从而引起疼痛。另外，子宫颈管狭窄，子宫过度倾屈，导致经血外流不畅，亦可引起痛经。
中医：痛经，月水来腹痛，经行腹痛，经期腹痛，经痛。中医学认为：妇女在经期及月经前后，生理上冲任的气血较平时变化急骤，此时若感病邪或潜在病因与气血相干，以致冲任、胞宫气血运行不畅，则"不通则痛"；或致冲任、胞宫失于濡养，而"不荣则痛"。痛经多因情志所伤。六淫为害，导致冲任阻滞，或因精血不足，胞脉失于濡养所致。
本发明所涉及药材研究现状如下：
肉穗草【别名】家阿麻。【来源】药材基源：为野牡丹科植物肉穗草的全草。采收和储藏：春、夏季采收，洗净，切碎晒干。【性味】味甘；涩；性凉。【归经】归肺经、肾经、肝经。【功能主治】清热利湿；消肿解毒。主热毒血痢；暑湿泄泻；肺热咳嗽；目赤肿痛；吐血；疔疮肿毒；外伤红肿；毒蛇咬伤。【用法用量】内服：煎汤，15～30g。【摘录】《中华本草》。
人面子【别名】人面果、银莲果。【来源】药材基源：为漆树科植物人面子的果实。采收和储藏：秋季采收果实，晒干，或渍盐。【性味】甘酸，平。【归经】脾；胃；肝经。【功能主治】健胃；生津；醒酒；解毒。主食欲不振；热病口渴；醉酒；咽喉肿痛；风毒疮痒。【用法用量】内服：煎汤，3～5g。【摘录】《中华本草》。
三股筋【别名】香叶，楠木香、梅叶香、羊角香、香叶子。【来源】药材基源：为樟科植物新樟的叶。采收和储藏：全年可采，鲜用或晒干备用。【性味】辛；涩；温。【归经】肝；脾经。【功能主治】祛风湿；舒筋络；散寒止痛；外用止血。主风湿感冒；风湿痹痛；胃寒疼痛；跌打伤痛，刀伤出血。【用法用量】内服：煎汤，3～9g。【注意】【摘录】《中华本草》。
太平莓【别名】老虎扭。【来源】药材基源：为薇科植物太平莓的全草。采收和储藏：6-8月割取带花、叶全草，洗净，充分晒干。【性味】酸、苦、辛；平。【归经】肝经。【功能主治】清热，活血。主产后腹痛。【用法用量】内服：煎汤，30～60g。【摘录】《中华本草》。
千解草【别名】小常山。【来源】药材基源：为马鞭草科植物千解草的全株。采收和储藏：全年均可采，切段或切片晒干。【性味】味微苦；甘；性微温。【归经】归肾经，胃经、肠经。【功能主治】活血止痛；祛风除湿；健脾消食。主跌打损伤；风湿痹痛；胃脘疼痛；消化不良；泄泻；疮疡肿毒。【用法用量】内服：煎汤，15～30g。【摘录】《中华本草》。
耳草【别名】较剪草、鲫鱼胆草、山过路蜈蚣、蜈蚣草、行路蜈蚣、节节花、鲫鱼草、龙胆草、苦胆草、节节白花、细叶假红兰、散血草、黑头草、荞糕草、野甘草。【来源】药材基源：为茜草科植物耳草的全草。采收和储藏：夏季采收，鲜用或晒干。【性味】苦；凉。【归经】归肺经、肠经。【功能主治】清热解毒；凉血消肿。主感冒发热；肺热咳嗽；咽喉肿痛；肠炎；痢疾；痔疮出血；崩漏；毒蛇咬伤；乳腺炎；痈疖肿毒；湿疹；跌打损伤。【用法用量】内服：煎汤，10～15g。【摘录】《中华本草》。
看麦娘【别名】牛头猛、山高粱、路边谷、道旁谷、油草、棒槌草。【来源】药材基源：为禾本科植物看麦娘的全草。采收和储藏：春、夏季采收，晒干或鲜用。【性味】淡；凉。【归经】归肝经。【功能主治】清热利湿；止泻；解毒。主水肿；水痘；泄泻；黄疸型肝炎；赤眼；毒蛇咬伤。【用法用量】内服：煎汤，30～60g。【摘录】《中华本草》。
粉萆【别名】黄萆、黄山姜、黄姜。【来源】为薯蓣科植物粉背薯蓣的根茎。秋、冬季采挖根茎，除去须根，切薄片，晒干。【性味】性平，味苦、甘。【归经】归肾经、脾经。【功能主治】利湿去浊，祛风除痹。用于膏淋、白浊、白带过多、风寒痹痛、关节不利、腰膝疼痛。【用法用量】内服：煎汤，3～6g。【摘录】《中华本草》。
发明内容
本发明旨在提供一种用于治疗原发性痛经的中药，通过选择合适的药材及其配比，达到安全有效治愈原发性痛经的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗原发性痛经的中药，其特征在于，它是由以下重量配比的原料药材制备而成：肉穗草15份、人面子5份、三股筋9份、太平莓18份、千解草12份、耳草10份、看麦娘15份、粉萆6份。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人2012年10月～2013年10月间共收集门诊及住院原发性痛经患者54例，随机分为治疗组34例与对照组20例，治疗组年龄16～47岁，病程：2个月～6年；对照组年龄18～46岁，病程：3个月～4年。2组性别、年龄及病程比较差异无统计学意义，具有可比性。
诊断标准
依据全国原发性痛经临床专业会议的诊断标准：
(一)体征
原发性痛经常发生在年轻女性，初潮后数月(6～12个月)开始，30岁以后发生率开始下降，疼痛常在月经即将来潮前或来潮后开始出现，并持续在月经期的前48～72h，疼痛常呈痉挛性，有时很重，以至于需卧床数小时或数天，疼痛集中在下腹正中，有时也伴腰痛或放射至股内侧，盆腔检查无阳性所见。
(二)检查
诊断原发性痛经，妇科检查无阳性体征为诊断原发性痛经的关键，主要是排除盆腔器质性病变的存在，采取完整的病史，做详细的体格检查(尤其是妇科检查)，排除子宫内膜异位症，子宫腺肌症，盆腔炎症等。
分泌物检查，激素水平检查。
B超，腹腔镜，宫腔镜，子宫输卵管碘油造影。
2、治疗方法
治疗组口服本发明按照具体实施例3制得的胶囊剂，每日3次。疗程3个月经周期。
对照组口服硝苯地平片，10mg，3次/d，疗程7天，疗程3个月经周期。
3、疗效标准与治疗结果
3.1疗效标准
临床控制：治疗后腹痛及其他症状消失，连续3个月经周期未复发；
显效：治疗后腹痛明显减轻，其余症状好转，不服止痛药能坚持工作，但不能维持3个月以上；
有效：治疗后腹痛减轻，其余症状好转，服止痛药能坚持工作。
无效：治疗后腹痛及其他症状未见改善。
3.2治疗结果见表1。
表1两组疗效比较
可见，本发明制得的药物能够安全有效治疗原发性痛经，具有推广价值。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
实施例1
称取：肉穗草15克、人面子5克、三股筋9克、太平莓18克、千解草12克、耳草10克、看麦娘15克、粉萆6克；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗原发性痛经。口服，每日分早午晚三次服用。
实施例2
称取：肉穗草15克、人面子5克、三股筋9克、太平莓18克、千解草12克、耳草10克、看麦娘15克、粉萆6克；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗原发性痛经。口服，每日分早午晚三次服用。
实施例3
称取：肉穗草15克、人面子5克、三股筋9克、太平莓18克、千解草12克、耳草10克、看麦娘15克、粉萆6克；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗原发性痛经。口服，每日分早午晚三次服用。
Claims (4)
1.一种用于治疗原发性痛经的中药，其特征在于，它是由以下重量配比的原料药材制备而成：肉穗草15份、人面子5份、三股筋9份、太平莓18份、千解草12份、耳草10份、看麦娘15份、粉萆6份。
2.如权利要求1所述的用于治疗原发性痛经的中药，其特征在于，其制备方法为：称取：肉穗草15份、人面子5份、三股筋9份、太平莓18份、千解草12份、耳草10份、看麦娘15份、粉萆6份；加8倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120份，即得煎剂；上述份均是指重量份。
3.如权利要求1所述的用于治疗原发性痛经的中药，其特征在于，其制备方法为：称取：肉穗草15份、人面子5份、三股筋9份、太平莓18份、千解草12份、耳草10份、看麦娘15份、粉萆6份；加10倍量水，煎煮2小时，过滤；滤渣加8倍量水，煎煮1.5小时，过滤；合并滤液，浓缩，干燥，包装，即得散剂；上述份均是指重量份。
4.如权利要求1所述的用于治疗原发性痛经的中药，其特征在于，其制备方法为：称取：肉穗草15份、人面子5份、三股筋9份、太平莓18份、千解草12份、耳草10份、看麦娘15份、粉萆6份；加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得胶囊剂；上述份均是指重量份。
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