CN105560826A - Traditional Chinese medicine composition granules for treating hyperosteogeny and preparation method of traditional Chinese medicine composition granules - Google Patents

Abstract

The invention provides traditional Chinese medicine composition granules for treating hyperosteogeny and a preparation method of the traditional Chinese medicine composition granules. The composition comprises the ingredients of colla corii asini, notopterygium incisum, evergreen mucuna root and leaves, stem of falsenettleleaf pepper, folium ciematis, cortex acanthopanacis, syzygium aromaticum, safflower, radix clematidis, radix puerariae, myrrh, lumbricus, tortoise plastron, herba epimedii, rhizoma anemarrhenae, chrysanthemum, radix ophiopogonis, Chinese wolfberries, scutellaria baicalensis, angelica sinensis, trichosanthes kirilowii, uncaria rhynchophylla, poria cocos, radix rehmanniae, rhizoma alismatis, radix puerariae, radix paeoniae alba, eucommia ulmoides, salvia miltiorrhiza, sealwort, semen cassiae, Chinese yam, liquorice and rhizoma podophylli emodi. The preparation method comprises the following steps: taking part of the ingredients, mixing and smashing, percolating with an ethanol water solution, concentrating a percolate, extracting the concentrated percolate with ethyl ether, and conducting reduced pressure recycle on the extract liquid to obtain an extract; taking the rest ingredients, adding purified water and conducting decoction, filtering a decocted liquid, concentrating a filtrate to obtain a concentrated liquid, adding ethanol, uniformly stirring, leaving to stand, filtering, and concentrating the filtrate to obtain a clear paste; mixing the extract and the clear paste, and conducting wet granulation so as to obtain the granules. The composition can improve the bone tissue activity, and has an obvious softening function on calcified hyperosteogeny.

Description

A kind of Chinese medicinal composition granules for the treatment of hyperosteogeny and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicinal composition granules for the treatment of hyperosteogeny and preparation method thereof.

Background technology

Hyperosteogeny of cervical vertebra is that degeneration appears in cervical vertebra, intervertebral disc is thinning, interbody space narrows, laxity of ligament, curvature changes, and between vertebral body, mobility increases, small, repeatedly, accumulation property damage is there is in vertebral rim, cause small local hemorrhage and ooze out, hemorrhage and ooze out progressively calcification, thus in local, namely there is the productive reaction of bone in the upper lower edge of vertebral body.Hyperosteogeny of cervical vertebra main and age, strain, wound, fault etc. have direct relation.Hyperosteogeny of cervical vertebra mostly occurs at 4-6 joint, the highest with the sickness rate of Section 5, reaches 83%.Each position hypertrophy rate is maximum with lower edge on unciform process, vertebral body and articular process.Patient usually feels cervical vertebra local pain, has a stiff neck, limitation of activity and upper limb is heavy, unable, numbness of the fingers and dizziness and nausea, blurred vision, insomnia forgetfulness, the symptom such as uncomfortable in chest, spirit is irritated.

Hyperosteogeny of cervical vertebra Producing reason has the following aspects: (1) cervical vertebra degenerative change: along with the different phase at age develops, different changes can be there is in cervical vertebra and intervertebral disc, while body of cervical vertebra generation degenerative change, also there is corresponding change in intervertebral disc; (2) strain and faulty posture: incidence is in single postural position for a long time, likes lying on a bed and sees that the crowds such as TV, reading, high pillow, seat sleep easily suffer from hyperosteogeny of cervical vertebra; Common crowd such as accounting, writer, software developer etc. need the worker that bows for a long time; Student, due to homework, over-burden, see that written word sitting posture is improper, blow air-conditioning or operating computer, less motion without limit for a long time, if add that the calcic food of taken long-term is few again, cervical vertebra is easy to produce bony spur hypertrophy phenomenon; (3) incidence wound: some patients make cervical spinal canal be in narrow critical state because of hyperosteogeny of cervical vertebra, prolapse of cervical intervertebral disc, intraspinal tube soft tissue lesions etc., the generation of the normal induced symptom of cervical trauma; (4) wind and cold wets factor: the wind and cold factor of wetting of external environment can reduce the tolerance of body to pain, muscle spasm can be made, thin vessels shrinks, lymphatic return slows down, soft tissue blood circulatory disorder, then aseptic inflammation is produced, therefore, the wind and cold factor of wetting is not only inducement, also can be used as the cause of disease and causes pathological changes to produce symptom; (5) dysplasia of instability: congenital little canalis spinalis, cervical spine degeneration etc. are some cervical spondylosis pathogenesis basis.

Cervical spine bone hyperplasia, gently then visible neck is uncomfortable, miserable pain; Heavy then spinal cord, vertebral artery, nerve root etc. can be merged get involved and become various types of cervical spondylosis, there is corresponding following clinical manifestation: (1) spondylotic radiculopathy symptom: after neck with take on back pain, have the feeling of numbness of acupuncture sample or electric shock sample; Restriction of neck motion, grasp weakness, finger movement is ineffective, and fine movement difficulty etc., hold incessantly thing; (2) myeloid form symptom; This kind of the most easily causes paralysis, shows as instability of gait more, and walking is heavy, sensation sole like stepping down on Cotton Gossypii, side or both upper extremities numb, hands is unable, or holds thing and easily lose; (3) adrenergic type symptom: blurred vision, eyelid is unable, and eye socket swells and ache, and sheds tears; Tachycardia or excessively slow, precordial pain and hypertension, limbs are sent out cool, temperature decline, and meeting cold limbs has prickling sensation, then occur that red and swollen or pain increases the weight of; Head, face, cervical region also can numb or pain, tinnitus, deafness, numbness of tongue etc.; (4) vertebral artery type symptom: headache, dizzy, cerebral ischemia; When head turns to a certain orientation, namely feel dizzy, Nausea and vomiting, tinnitus, deafness, blurring of vision etc.; Unexpected numb limbs and tense tendons, paraesthesia, holds thing unable or fall down suddenly.

Summary of the invention

The object of the invention is to overcome the deficiencies in the prior art and a kind of Chinese medicine composition for the treatment of hyperosteogeny and preparation method thereof is provided, resulting composition can increase osseous tissue activity, obvious emollescence is had to the hyperosteogeny of calcification, blood circulation promoting and blood stasis dispelling, detumescence dismiss successful, and hyperosteogeny relapse rate is low.

A kind of Chinese medicinal composition granules for the treatment of hyperosteogeny, comprise with parts by weight: 3 ~ 8 parts, Colla Corii Asini, Rhizoma Et Radix Notopterygii 1 ~ 9 part, Radix Seu Caulis Mucunae Sempervirentis 2 ~ 8 parts, Caulis Piperis Boehmeriaefolii 1 ~ 7 part, Clematis filamentosa Dunn 3 ~ 10 parts, Cortex Acanthopancis 2 ~ 9 parts, Flos Caryophylli 1 ~ 7 part, 2 ~ 8 parts, Flos Carthami, Radix Clematidis 1 ~ 7 part, Radix Puerariae 2 ~ 8 parts, Myrrha 3 ~ 10 parts, Pheretima 1 ~ 6 part, Carapax et Plastrum Testudinis 2 ~ 8 parts, Herba Epimedii 1 ~ 7 part, the Rhizoma Anemarrhenae 2 ~ 10 parts, Flos Chrysanthemi 3 ~ 9 parts, Radix Ophiopogonis 1 ~ 6 part, Fructus Lycii 2 ~ 9 parts, Radix Scutellariae 3 ~ 10 parts, Radix Angelicae Sinensis 2 ~ 8 parts, Chinese juniper beach wormwood 1 ~ 6 part, Ramulus Uncariae Cum Uncis 2 ~ 7 parts, 3 ~ 9 parts, Poria, 2 ~ 8 parts, the Radix Rehmanniae, Rhizoma Alismatis 1 ~ 6 part, Radix Puerariae 2 ~ 9 parts, the Radix Paeoniae Alba 1 ~ 6 part, the Cortex Eucommiae 3 ~ 8 parts, Radix Salviae Miltiorrhizae 2 ~ 10 parts, Rhizoma Polygonati 1 ~ 7 part, Semen Cassiae 2 ~ 7 parts, Rhizoma Dioscoreae 1 ~ 6 part, 2 ~ 8 parts, Radix Glycyrrhizae, Rhizoma Dysosmae Versipellis 1 ~ 5 part.

Colla Corii Asini: sweet in the mouth, property are flat.Return liver, lung, kidney channel.There is enriching blood, stop blooding, YIN nourishing, the effect of moisturizing.Cure mainly syndrome of deficiency of blood, asthenia spitting of blood, haematemesis, hematuria, have blood in stool, dysentery, gestation hemorrhage, metrorrhagia, the vexed insomnia of the deficiency of YIN, deficiency of the lung bath are coughed, the convulsion of stirring-up of pathogenic wind in the interior resulting from deficiency is fainted tic.

Rhizoma Et Radix Notopterygii: acrid in the mouth, hardship, warm in nature.Return bladder, kidney channel.There is effect of loose exterior cold, wind-damp dispelling, sharp joint, pain relieving.Cure mainly affection of exogenous wind-cold, have a headache lossless, mimeograph cold-damp numbness, edema due to wind pathogen edema, sore swollen toxin.

Radix Seu Caulis Mucunae Sempervirentis: bitter in the mouth, micro-hardship, warm in nature.Return liver, stomach warp.There is promoting blood flow to regulate menstruation, the effect of relaxing muscles and tendons of enriching blood.Cure mainly menoxenia, dysmenorrhea, amenorrhea, puerperal blood deficiency, anemia, rheumatic arthralgia, numb limbs and tense tendons, traumatic injury.

Caulis Piperis Boehmeriaefolii: pungent, warm.Return lung, the heart, liver, spleen, stomach warp.There is effect of expelling wind and removing dampness, eliminating dampness and dredging channels.Cure mainly cold, rheumatic arthralgia, stomachache, menoxenia, traumatic injury, fracture.

Clematis filamentosa Dunn: bitter in the mouth, slightly cool in nature.GUIXIN, Liver Channel.There is effect of clearing away liver-fire, mind calming god, blood pressure lowering, removing obstruction in the collateral to relieve pain.Cure mainly hypertension, insomnia, headache, numb limbs and tense tendons, wind-heat of liver channel, conjunctival congestion and swelling pain, acute toothache, rheumatic arthralgia.

Cortex Acanthopancis: acrid in the mouth, hardship, warm in nature.Return liver, kidney channel.There is effect of wind-damp dispelling, bone and muscle strengthening, promoting blood circulation and stopping pain.Cure mainly rheumatic arthralgia, contracture numbness, soreness of the waist and knees, sufficient knee joint without business, traumatic injury, eczema scrotum.

Radix Clematidis: acrid in the mouth, salty, micro-hardship, warm in nature, mild toxicity.Return bladder, Liver Channel.There is effect of expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.Cure mainly rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins, joint stuffiness, beriberi swells and ache, malaria, bone choke with sobs larynx and control phlegm retention and gather.

Radix Puerariae: nature and flavor are sweet, pungent, flat.Return spleen, stomach, lung, urinary bladder channel.There is expelling pathogenic factors from muscles for reducing heat, deliver examine, promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal.Cure mainly fever caused by exogenous pathogens, rigidity pain on the head and nape, measles from the beginning of, rash go out smooth, epidemic febrile disease is thirsty, diabetes, have loose bowels, dysentery, hypertension, coronary heart disease.

Myrrha: bitter in the mouth, property are flat.Return liver, spleen, the heart, kidney channel.There is effect of promoting blood circulation and stopping pain, detumescence and promoting granulation.Cure mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, mass in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.

Pheretima: salty in the mouth, cold in nature.Return liver, spleen, urinary bladder channel.There is effect of gesture relieving convulsion, suppressing the hyperactive liver to relieve the wind syndrome, dredge the meridian passage, diuresis of relievining asthma clearly.Cure mainly mad dry, the infantile convulsion tic of calentura heating, headache due to hyperactivity of liver-YANG, apoplectic hemiplegia, rheumatic arthralgia, dyspnea and cough due to lung-heat, urinary obstruction.

Herba Epimedii: acrid in the mouth, sweet, warm in nature.Return liver, kidney channel.Have that kidney invigorating and YANG supporting, expelling wind and removing dampness, the effect impotence and seminal emission of strong muscle key bone, cold caused by deficiency are sterile, frequent micturition loses Chu, dyspnea and cough due to deficiency of the kidney, soreness of the waist and knees, rheumatic arthralgia, hemiplegia, extremity are meciless.

The Rhizoma Anemarrhenae: bitter in the mouth, cold in nature.Return lung, stomach, kidney channel.There is effect of clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, relieving restlessness of quenching the thirst.Cure mainly epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, stranguria with turbid discharge of quenching one's thirst.

Ramulus Uncariae Cum Uncis: sweetness and bitterness, to be slightly cold.Return liver, heart channel.There is effect of heat clearing away suppressing the hyperactive liver, relieving spasm by subduing liver-wind.Cure mainly infantile convulsion, night cry, intenseness of heat wind symptom, eclamposia, dizziness due to hyperactivity of liver-YANG, liver-fire distending pain in the head.

Poria: sweet, light, flat.GUIXIN, spleen, lung, kidney channel.There is effect of eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.Cure mainly dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, have loose bowels, palpitation and restlessness, insomnia forgetfulness, seminal emission nebulousurine.

Rhizoma Alismatis: sweet in the mouth, light, cold in nature.Return kidney, urinary bladder channel.There is promoting diuresis to eliminate damp pathogen, expel the heat-evil treating stranguria effect.Cure mainly dysuria, the puckery pain of pyretic stranguria, edema distension, have loose bowels, dizziness due to fluid-retention, seminal emission.

Rhizoma Polygonati: nature and flavor are sweet, flat.Return spleen, lung, kidney channel.There is effect of nourishing YIN and moistening the lung, invigorating the spleen and replenishing QI, Zishen fill fine.Cure mainly deficiency of YIN chronic cough, xeropulmonary cough, insufficiency of the spleen weak, lack of appetite xerostomia, quench one's thirst, deficiency of the kidney soreness of the waist and knees, impotence and seminal emission, tinnitus order are dark, early whitening of beard and hair, body void wins thin, wind favus disease.

The preparation method of the Chinese medicine composition of above-mentioned treatment hyperosteogeny, comprises the following steps:

Step 1, get Colla Corii Asini, Rhizoma Et Radix Notopterygii, Radix Seu Caulis Mucunae Sempervirentis, Caulis Piperis Boehmeriaefolii, Clematis filamentosa Dunn, Cortex Acanthopancis, Flos Caryophylli, Flos Carthami, Radix Clematidis, Radix Puerariae, Myrrha, Pheretima, Carapax et Plastrum Testudinis, Herba Epimedii, the Rhizoma Anemarrhenae, Flos Chrysanthemi and mixing Radix Ophiopogonis, be ground into coarse powder, percolation is carried out with after ethanol water dipping, collect percolate, reclaim ethanol and obtain concentrated solution, by extracted with diethyl ether, combining extraction liquid reclaim under reduced pressure obtains extract;

Step 2, get Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis, add pure water to decoct, decocting liquid filters, and filtrate concentrates to obtain concentrated solution, adds ethanol, stir evenly, leave standstill, filter, filtrate is concentrated to obtain clear paste;

Step 3, merges extract obtained for step 1 and step 2 gained clear paste, after wet granulation and get final product.

As the further improvement of foregoing invention, in step 1, coarse powder particle diameter is 40 ~ 60 orders.

As the further improvement of foregoing invention, in step 1, the concentration of ethanol water is 60 ~ 80wt.%.

As the further improvement of foregoing invention, in step 1, percolation speed is 3 ~ 5mL/min.

As the further improvement of foregoing invention, the amount adding pure water in step 2 be Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis gross weight 6 ~ 9 times.

As the further improvement of foregoing invention, in step 2, the relative density of gained clear paste at 80 DEG C is 1.2 ~ 1.3.

As the further improvement of foregoing invention, the Radix Paeoniae Alba is yellow wine system, concocts step to be: the Radix Paeoniae Alba adds yellow wine and mixes thoroughly, after vexed, and parch at 210 ~ 220 DEG C.

Compositions of the present invention can increase osseous tissue activity, has obvious emollescence to the hyperosteogeny of calcification, and blood circulation promoting and blood stasis dispelling, detumescence dismiss successful, and hyperosteogeny relapse rate is low.The concocting method of the Radix Paeoniae Alba is adjusted to yellow wine system by traditional water soaking, oven dry, effectively can reduces the friability of granule, make particulate composition be easier to store and transport.

Detailed description of the invention

Embodiment 1

A kind of Chinese medicine composition for the treatment of hyperosteogeny, comprise with parts by weight: 3 parts, Colla Corii Asini, Rhizoma Et Radix Notopterygii 1 part, Radix Seu Caulis Mucunae Sempervirentis 2 parts, Caulis Piperis Boehmeriaefolii 1 part, Clematis filamentosa Dunn 3 parts, Cortex Acanthopancis 2 parts, Flos Caryophylli 1 part, 2 parts, Flos Carthami, Radix Clematidis 1 part, Radix Puerariae 2 parts, Myrrha 3 parts, Pheretima 1 part, Carapax et Plastrum Testudinis 2 parts, Herba Epimedii 1 part, the Rhizoma Anemarrhenae 2 parts, Flos Chrysanthemi 3 parts, Radix Ophiopogonis 1 part, Fructus Lycii 2 parts, Radix Scutellariae 3 parts, Radix Angelicae Sinensis 2 parts, Chinese juniper beach wormwood 1 part, Ramulus Uncariae Cum Uncis 2 parts, 3 parts, Poria, 2 parts, the Radix Rehmanniae, Rhizoma Alismatis 1 part, Radix Puerariae 2 parts, the Radix Paeoniae Alba 1 part, the Cortex Eucommiae 3 parts, Radix Salviae Miltiorrhizae 2 parts, Rhizoma Polygonati 1 part, Semen Cassiae 2 parts, Rhizoma Dioscoreae 1 part, 2 parts, Radix Glycyrrhizae, Rhizoma Dysosmae Versipellis 1 part.

The preparation method of the Chinese medicine composition of above-mentioned treatment hyperosteogeny, comprises the following steps:

Step 1, get Colla Corii Asini, Rhizoma Et Radix Notopterygii, Radix Seu Caulis Mucunae Sempervirentis, Caulis Piperis Boehmeriaefolii, Clematis filamentosa Dunn, Cortex Acanthopancis, Flos Caryophylli, Flos Carthami, Radix Clematidis, Radix Puerariae, Myrrha, Pheretima, Carapax et Plastrum Testudinis, Herba Epimedii, the Rhizoma Anemarrhenae, Flos Chrysanthemi and mixing Radix Ophiopogonis, be ground into coarse powder, coarse powder particle diameter is 40 orders, and carry out percolation with after 60wt.% ethanol water dipping, percolation speed is 3mL/min, collect percolate, reclaim ethanol and obtain concentrated solution, by extracted with diethyl ether, combining extraction liquid reclaim under reduced pressure obtains extract;

Step 2, get Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis, add pure water to decoct, decocting liquid filters, filtrate concentrates to obtain concentrated solution, add ethanol, stir evenly, leave standstill, filter, filtrate is concentrated to obtain clear paste, the relative density of gained clear paste at 80 DEG C is 1.2, the amount adding pure water is Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis gross weight 6 times,

Step 3, merges extract obtained for step 1 and step 2 gained clear paste, after wet granulation and get final product.

Embodiment 2

A kind of Chinese medicine composition for the treatment of hyperosteogeny, comprise with parts by weight: 5 parts, Colla Corii Asini, Rhizoma Et Radix Notopterygii 2 parts, Radix Seu Caulis Mucunae Sempervirentis 6 parts, Caulis Piperis Boehmeriaefolii 4 parts, Clematis filamentosa Dunn 9 parts, Cortex Acanthopancis 8 parts, Flos Caryophylli 5 parts, 6 parts, Flos Carthami, Radix Clematidis 5 parts, Radix Puerariae 3 parts, Myrrha 7 parts, Pheretima 2 parts, Carapax et Plastrum Testudinis 3 parts, Herba Epimedii 5 parts, the Rhizoma Anemarrhenae 7 parts, Flos Chrysanthemi 8 parts, Radix Ophiopogonis 3 parts, Fructus Lycii 6 parts, Radix Scutellariae 5 parts, Radix Angelicae Sinensis 6 parts, Chinese juniper beach wormwood 3 parts, Ramulus Uncariae Cum Uncis 5 parts, 4 parts, Poria, 7 parts, the Radix Rehmanniae, Rhizoma Alismatis 2 parts, Radix Puerariae 3 parts, the Radix Paeoniae Alba 5 parts, the Cortex Eucommiae 7 parts, Radix Salviae Miltiorrhizae 9 parts, Rhizoma Polygonati 2 parts, Semen Cassiae 4 parts, Rhizoma Dioscoreae 3 parts, 6 parts, Radix Glycyrrhizae, Rhizoma Dysosmae Versipellis 2 parts.

The preparation method of the Chinese medicine composition of above-mentioned treatment hyperosteogeny, comprises the following steps:

Step 1, get Colla Corii Asini, Rhizoma Et Radix Notopterygii, Radix Seu Caulis Mucunae Sempervirentis, Caulis Piperis Boehmeriaefolii, Clematis filamentosa Dunn, Cortex Acanthopancis, Flos Caryophylli, Flos Carthami, Radix Clematidis, Radix Puerariae, Myrrha, Pheretima, Carapax et Plastrum Testudinis, Herba Epimedii, the Rhizoma Anemarrhenae, Flos Chrysanthemi and mixing Radix Ophiopogonis, be ground into coarse powder, coarse powder particle diameter is 50 orders, and carry out percolation with after 65wt.% ethanol water dipping, percolation speed is 4mL/min, collect percolate, reclaim ethanol and obtain concentrated solution, by extracted with diethyl ether, combining extraction liquid reclaim under reduced pressure obtains extract;

Step 2, get Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis, add pure water to decoct, decocting liquid filters, filtrate concentrates to obtain concentrated solution, add ethanol, stir evenly, leave standstill, filter, filtrate is concentrated to obtain clear paste, the relative density of gained clear paste at 80 DEG C is 1.3, the amount adding pure water is Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis gross weight 7 times,

Step 3, merges extract obtained for step 1 and step 2 gained clear paste, after wet granulation and get final product.

Embodiment 3

A kind of Chinese medicine composition for the treatment of hyperosteogeny, comprise with parts by weight: 5 parts, Colla Corii Asini, Rhizoma Et Radix Notopterygii 8 parts, Radix Seu Caulis Mucunae Sempervirentis 6 parts, Caulis Piperis Boehmeriaefolii 5 parts, Clematis filamentosa Dunn 6 parts, Cortex Acanthopancis 5 parts, Flos Caryophylli 3 parts, 7 parts, Flos Carthami, Radix Clematidis 2 parts, Radix Puerariae 5 parts, Myrrha 6 parts, Pheretima 3 parts, Carapax et Plastrum Testudinis 5 parts, Herba Epimedii 2 parts, the Rhizoma Anemarrhenae 8 parts, Flos Chrysanthemi 6 parts, Radix Ophiopogonis 3 parts, Fructus Lycii 8 parts, Radix Scutellariae 6 parts, Radix Angelicae Sinensis 5 parts, Chinese juniper beach wormwood 3 parts, Ramulus Uncariae Cum Uncis 4 parts, 8 parts, Poria, 6 parts, the Radix Rehmanniae, Rhizoma Alismatis 2 parts, Radix Puerariae 6 parts, the Radix Paeoniae Alba 2 parts, the Cortex Eucommiae 6 parts, Radix Salviae Miltiorrhizae 4 parts, Rhizoma Polygonati 3 parts, Semen Cassiae 5 parts, Rhizoma Dioscoreae 3 parts, 6 parts, Radix Glycyrrhizae, Rhizoma Dysosmae Versipellis 4 parts.

The preparation method of the Chinese medicine composition of above-mentioned treatment hyperosteogeny, comprises the following steps:

Step 1, get Colla Corii Asini, Rhizoma Et Radix Notopterygii, Radix Seu Caulis Mucunae Sempervirentis, Caulis Piperis Boehmeriaefolii, Clematis filamentosa Dunn, Cortex Acanthopancis, Flos Caryophylli, Flos Carthami, Radix Clematidis, Radix Puerariae, Myrrha, Pheretima, Carapax et Plastrum Testudinis, Herba Epimedii, the Rhizoma Anemarrhenae, Flos Chrysanthemi and mixing Radix Ophiopogonis, be ground into coarse powder, coarse powder particle diameter is 50 orders, and carry out percolation with after 80wt.% ethanol water dipping, percolation speed is 5mL/min, collect percolate, reclaim ethanol and obtain concentrated solution, by extracted with diethyl ether, combining extraction liquid reclaim under reduced pressure obtains extract;

Step 2, get Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis, add pure water to decoct, decocting liquid filters, filtrate concentrates to obtain concentrated solution, add ethanol, stir evenly, leave standstill, filter, filtrate is concentrated to obtain clear paste, the relative density of gained clear paste at 80 DEG C is 1.3, the amount adding pure water is Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis gross weight 9 times,

Step 3, merges extract obtained for step 1 and step 2 gained clear paste, after wet granulation and get final product.

Embodiment 4

A kind of Chinese medicine composition for the treatment of hyperosteogeny, comprise with parts by weight: 7 parts, Colla Corii Asini, Rhizoma Et Radix Notopterygii 3 parts, Radix Seu Caulis Mucunae Sempervirentis 5 parts, Caulis Piperis Boehmeriaefolii 3 parts, Clematis filamentosa Dunn 5 parts, Cortex Acanthopancis 6 parts, Flos Caryophylli 3 parts, 4 parts, Flos Carthami, Radix Clematidis 6 parts, Radix Puerariae 3 parts, Myrrha 5 parts, Pheretima 4 parts, Carapax et Plastrum Testudinis 6 parts, Herba Epimedii 3 parts, the Rhizoma Anemarrhenae 6 parts, Flos Chrysanthemi 5 parts, Radix Ophiopogonis 2 parts, Fructus Lycii 4 parts, Radix Scutellariae 5 parts, Radix Angelicae Sinensis 7 parts, Chinese juniper beach wormwood 2 parts, Ramulus Uncariae Cum Uncis 3 parts, 6 parts, Poria, 5 parts, the Radix Rehmanniae, Rhizoma Alismatis 2 parts, Radix Puerariae 3 parts, the Radix Paeoniae Alba 5 parts, the Cortex Eucommiae 6 parts, Radix Salviae Miltiorrhizae 4 parts, Rhizoma Polygonati 2 parts, Semen Cassiae 4 parts, Rhizoma Dioscoreae 2 parts, 6 parts, Radix Glycyrrhizae, Rhizoma Dysosmae Versipellis 3 parts.

The preparation method of the Chinese medicine composition of above-mentioned treatment hyperosteogeny, comprises the following steps:

Step 1, get Colla Corii Asini, Rhizoma Et Radix Notopterygii, Radix Seu Caulis Mucunae Sempervirentis, Caulis Piperis Boehmeriaefolii, Clematis filamentosa Dunn, Cortex Acanthopancis, Flos Caryophylli, Flos Carthami, Radix Clematidis, Radix Puerariae, Myrrha, Pheretima, Carapax et Plastrum Testudinis, Herba Epimedii, the Rhizoma Anemarrhenae, Flos Chrysanthemi and mixing Radix Ophiopogonis, be ground into coarse powder, coarse powder particle diameter is 40 orders, and carry out percolation with after 60wt.% ethanol water dipping, percolation speed is 3mL/min, collect percolate, reclaim ethanol and obtain concentrated solution, by extracted with diethyl ether, combining extraction liquid reclaim under reduced pressure obtains extract;

Step 2, get Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis, add pure water to decoct, decocting liquid filters, filtrate concentrates to obtain concentrated solution, add ethanol, stir evenly, leave standstill, filter, filtrate is concentrated to obtain clear paste, the relative density of gained clear paste at 80 DEG C is 1.2, the amount adding pure water is Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis gross weight 6 times,

Step 3, merges extract obtained for step 1 and step 2 gained clear paste, after wet granulation and get final product.

Embodiment 5

A kind of Chinese medicine composition for the treatment of hyperosteogeny, comprise with parts by weight: 8 parts, Colla Corii Asini, Rhizoma Et Radix Notopterygii 9 parts, Radix Seu Caulis Mucunae Sempervirentis 8 parts, Caulis Piperis Boehmeriaefolii 7 parts, Clematis filamentosa Dunn 10 parts, Cortex Acanthopancis 9 parts, Flos Caryophylli 7 parts, 8 parts, Flos Carthami, Radix Clematidis 7 parts, Radix Puerariae 8 parts, Myrrha 10 parts, Pheretima 6 parts, Carapax et Plastrum Testudinis 8 parts, Herba Epimedii 7 parts, the Rhizoma Anemarrhenae 10 parts, Flos Chrysanthemi 9 parts, Radix Ophiopogonis 6 parts, Fructus Lycii 9 parts, Radix Scutellariae 10 parts, Radix Angelicae Sinensis 8 parts, Chinese juniper beach wormwood 6 parts, Ramulus Uncariae Cum Uncis 7 parts, 9 parts, Poria, 8 parts, the Radix Rehmanniae, Rhizoma Alismatis 6 parts, Radix Puerariae 9 parts, the Radix Paeoniae Alba 6 parts, the Cortex Eucommiae 8 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Polygonati 7 parts, Semen Cassiae 7 parts, Rhizoma Dioscoreae 6 parts, 8 parts, Radix Glycyrrhizae, Rhizoma Dysosmae Versipellis 5 parts.

The preparation method of the Chinese medicine composition of above-mentioned treatment hyperosteogeny, comprises the following steps:

Step 1, get Colla Corii Asini, Rhizoma Et Radix Notopterygii, Radix Seu Caulis Mucunae Sempervirentis, Caulis Piperis Boehmeriaefolii, Clematis filamentosa Dunn, Cortex Acanthopancis, Flos Caryophylli, Flos Carthami, Radix Clematidis, Radix Puerariae, Myrrha, Pheretima, Carapax et Plastrum Testudinis, Herba Epimedii, the Rhizoma Anemarrhenae, Flos Chrysanthemi and mixing Radix Ophiopogonis, be ground into coarse powder, coarse powder particle diameter is 60 orders, and carry out percolation with after 80wt.% ethanol water dipping, percolation speed is 5mL/min, collect percolate, reclaim ethanol and obtain concentrated solution, by extracted with diethyl ether, combining extraction liquid reclaim under reduced pressure obtains extract;

Step 2, get Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis, add pure water to decoct, decocting liquid filters, filtrate concentrates to obtain concentrated solution, add ethanol, stir evenly, leave standstill, filter, filtrate is concentrated to obtain clear paste, the relative density of gained clear paste at 80 DEG C is 1.2, the amount adding pure water is Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis gross weight 9 times,

Step 3, merges extract obtained for step 1 and step 2 gained clear paste, after wet granulation and get final product.

Embodiment 6

Be with the difference of embodiment 5: the Radix Paeoniae Alba is through yellow wine system, concocting step is: the Radix Paeoniae Alba adds yellow wine and mixes thoroughly, after vexed, and parch at 210 ~ 220 DEG C.

A kind of Chinese medicine composition for the treatment of hyperosteogeny, comprise with parts by weight: 8 parts, Colla Corii Asini, Rhizoma Et Radix Notopterygii 9 parts, Radix Seu Caulis Mucunae Sempervirentis 8 parts, Caulis Piperis Boehmeriaefolii 7 parts, Clematis filamentosa Dunn 10 parts, Cortex Acanthopancis 9 parts, Flos Caryophylli 7 parts, 8 parts, Flos Carthami, Radix Clematidis 7 parts, Radix Puerariae 8 parts, Myrrha 10 parts, Pheretima 6 parts, Carapax et Plastrum Testudinis 8 parts, Herba Epimedii 7 parts, the Rhizoma Anemarrhenae 10 parts, Flos Chrysanthemi 9 parts, Radix Ophiopogonis 6 parts, Fructus Lycii 9 parts, Radix Scutellariae 10 parts, Radix Angelicae Sinensis 8 parts, Chinese juniper beach wormwood 6 parts, Ramulus Uncariae Cum Uncis 7 parts, 9 parts, Poria, 8 parts, the Radix Rehmanniae, Rhizoma Alismatis 6 parts, Radix Puerariae 9 parts, the Radix Paeoniae Alba 6 parts, the Cortex Eucommiae 8 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Polygonati 7 parts, Semen Cassiae 7 parts, Rhizoma Dioscoreae 6 parts, 8 parts, Radix Glycyrrhizae, Rhizoma Dysosmae Versipellis 5 parts.

The preparation method of the Chinese medicine composition of above-mentioned treatment hyperosteogeny, comprises the following steps:

Step 1, get Colla Corii Asini, Rhizoma Et Radix Notopterygii, Radix Seu Caulis Mucunae Sempervirentis, Caulis Piperis Boehmeriaefolii, Clematis filamentosa Dunn, Cortex Acanthopancis, Flos Caryophylli, Flos Carthami, Radix Clematidis, Radix Puerariae, Myrrha, Pheretima, Carapax et Plastrum Testudinis, Herba Epimedii, the Rhizoma Anemarrhenae, Flos Chrysanthemi and mixing Radix Ophiopogonis, be ground into coarse powder, coarse powder particle diameter is 60 orders, and carry out percolation with after 80wt.% ethanol water dipping, percolation speed is 5mL/min, collect percolate, reclaim ethanol and obtain concentrated solution, by extracted with diethyl ether, combining extraction liquid reclaim under reduced pressure obtains extract;

Step 2, get Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba (yellow wine system), the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis, add pure water to decoct, decocting liquid filters, filtrate concentrates to obtain concentrated solution, add ethanol, stir evenly, leave standstill, filter, filtrate is concentrated to obtain clear paste, the relative density of gained clear paste at 80 DEG C is 1.2, the amount adding pure water is Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis gross weight 9 times,

Step 3, merges extract obtained for step 1 and step 2 gained clear paste, after wet granulation and get final product.

Friability test method

It is that the bead of 7mm is put together in friability instrument and rotated 100 times that the granule getting more than 20g40 order adds 25 diameters, collects, crosses 40 mesh sieves, take the weight of the upper granule of sieve, count particles percentage loss of weight.

As can be seen from the table, after the Radix Paeoniae Alba is adjusted to yellow wine system, effectively can reduce the friability of granule, make granule be easier to store and transport.

Experimental example

" Chinese medical disease Standardization of diagnosis and curative effect " (ZY/T001.1-94) that diagnostic criteria is issued according to State Administration of Traditional Chinese Medicine formulates.CT or MRI checks prompting lumbar vertebra hyperosteogeny.Select 100 routine lumbar hyperosteogency patients, wherein man 52 example, female 48 example, patient age 41-72 year, the mean age be (51.5 ± 1.5) year, be two groups by patient, be respectively treatment group 1 and treatment group 2, often group has 50 routine patients.Two groups of Genders, age, the course of disease, symptom, there are no significant in sick position difference, have comparability (P > 0.05).

Treatment group 1 uses resulting composition in embodiment 1 to treat, every day twice, each serving using compositions 5g, and treatment 20 days continuously.

Treatment group 2 uses resulting composition in embodiment 2 to treat, every day twice, each serving using compositions 5g, and treatment 20 days continuously.

Criterion of therapeutical effect

" Chinese medical disease Standardization of diagnosis and curative effect " (ZY/T001.1-94) that issue with reference to State Administration of Traditional Chinese Medicine formulates.

Cure: lumbago and skelalgia disappears, and leg raising straight more than 70 °, can recover original work.

Effective: lumbago and skelalgia obviously alleviates, waist lower limb functional activity is close to normal, and leg raising straight 60 °-70 °, can recover originally to work or changed comparatively light work.

Effective: waist lower limb symptom partial disappearance, functional activity improves, leg raising straight about 60 °.

Invalid: sings and symptoms is without improvement.

Statistical method

Utilize SPSS13.0 software to process and analyze to experimental data, measurement data represents with mean ± standard deviation, adopts t inspection, and enumeration data adopts x2 inspection, and P < 0.05 represents that difference has statistical significance.

Result

Through treatment, for treatment group 1, cure 19 examples, effective 12 examples, effective 13 examples, invalid 6 examples, total effective rate is 88%, for treatment group 2, cures 26 examples, effective 15 examples, and effective 9 examples, total effective rate is 100%.Two groups of total effective rate comparing differences have statistical significance (P < 0.05).

Claims (8)

1. treat the Chinese medicinal composition granules of hyperosteogeny for one kind, it is characterized in that: comprise with parts by weight: 3 ~ 8 parts, Colla Corii Asini, Rhizoma Et Radix Notopterygii 1 ~ 9 part, Radix Seu Caulis Mucunae Sempervirentis 2 ~ 8 parts, Caulis Piperis Boehmeriaefolii 1 ~ 7 part, Clematis filamentosa Dunn 3 ~ 10 parts, Cortex Acanthopancis 2 ~ 9 parts, Flos Caryophylli 1 ~ 7 part, 2 ~ 8 parts, Flos Carthami, Radix Clematidis 1 ~ 7 part, Radix Puerariae 2 ~ 8 parts, Myrrha 3 ~ 10 parts, Pheretima 1 ~ 6 part, Carapax et Plastrum Testudinis 2 ~ 8 parts, Herba Epimedii 1 ~ 7 part, the Rhizoma Anemarrhenae 2 ~ 10 parts, Flos Chrysanthemi 3 ~ 9 parts, Radix Ophiopogonis 1 ~ 6 part, Fructus Lycii 2 ~ 9 parts, Radix Scutellariae 3 ~ 10 parts, Radix Angelicae Sinensis 2 ~ 8 parts, Chinese juniper beach wormwood 1 ~ 6 part, Ramulus Uncariae Cum Uncis 2 ~ 7 parts, 3 ~ 9 parts, Poria, 2 ~ 8 parts, the Radix Rehmanniae, Rhizoma Alismatis 1 ~ 6 part, Radix Puerariae 2 ~ 9 parts, the Radix Paeoniae Alba 1 ~ 6 part, the Cortex Eucommiae 3 ~ 8 parts, Radix Salviae Miltiorrhizae 2 ~ 10 parts, Rhizoma Polygonati 1 ~ 7 part, Semen Cassiae 2 ~ 7 parts, Rhizoma Dioscoreae 1 ~ 6 part, 2 ~ 8 parts, Radix Glycyrrhizae, Rhizoma Dysosmae Versipellis 1 ~ 5 part.

2. the preparation method of the Chinese medicinal composition granules for the treatment of hyperosteogeny according to claim 1, is characterized in that: comprise the following steps:

Step 1, get Colla Corii Asini, Rhizoma Et Radix Notopterygii, Radix Seu Caulis Mucunae Sempervirentis, Caulis Piperis Boehmeriaefolii, Clematis filamentosa Dunn, Cortex Acanthopancis, Flos Caryophylli, Flos Carthami, Radix Clematidis, Radix Puerariae, Myrrha, Pheretima, Carapax et Plastrum Testudinis, Herba Epimedii, the Rhizoma Anemarrhenae, Flos Chrysanthemi and mixing Radix Ophiopogonis, be ground into coarse powder, percolation is carried out with after ethanol water dipping, collect percolate, reclaim ethanol and obtain concentrated solution, by extracted with diethyl ether, combining extraction liquid reclaim under reduced pressure obtains extract;

Step 2, get Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis, add pure water to decoct, decocting liquid filters, and filtrate concentrates to obtain concentrated solution, adds ethanol, stir evenly, leave standstill, filter, filtrate is concentrated to obtain clear paste;

Step 3, merges extract obtained for step 1 and step 2 gained clear paste, after wet granulation and get final product.

3. the preparation method of the Chinese medicinal composition granules for the treatment of hyperosteogeny according to claim 2, is characterized in that: in step 1, coarse powder particle diameter is 40 ~ 60 orders.

4. the preparation method of the Chinese medicinal composition granules for the treatment of hyperosteogeny according to claim 2, is characterized in that: in step 1, the concentration of ethanol water is 60 ~ 80wt.%.

5. the preparation method of the Chinese medicinal composition granules for the treatment of hyperosteogeny according to claim 2, is characterized in that: in step 1, percolation speed is 3 ~ 5mL/min.

6. the preparation method of the Chinese medicinal composition granules for the treatment of hyperosteogeny according to claim 2, is characterized in that: the amount adding pure water in step 2 be Fructus Lycii, Radix Scutellariae, Radix Angelicae Sinensis, Chinese juniper beach wormwood, Ramulus Uncariae Cum Uncis, Poria, the Radix Rehmanniae, Rhizoma Alismatis, Radix Puerariae, the Radix Paeoniae Alba, the Cortex Eucommiae, Radix Salviae Miltiorrhizae, Rhizoma Polygonati, Semen Cassiae, Rhizoma Dioscoreae, Radix Glycyrrhizae and Rhizoma Dysosmae Versipellis gross weight 6 ~ 9 times.

7. the preparation method of the Chinese medicinal composition granules for the treatment of hyperosteogeny according to claim 2, is characterized in that: in step 2, the relative density of gained clear paste at 80 DEG C is 1.2 ~ 1.3.

8. the preparation method of the Chinese medicinal composition granules for the treatment of hyperosteogeny according to claim 2, is characterized in that: the Radix Paeoniae Alba is yellow wine system, concocts step to be: the Radix Paeoniae Alba adds yellow wine and mixes thoroughly, after vexed, and parch at 210 ~ 220 DEG C.