CN105560439A - Method for treating insomnia during perimenopausal period - Google Patents

Abstract

The invention relates to a method for treating insomnia during the perimenopausal period. According to the method, reinforcing qi and nourishing blood and warming and subsiding serve as treatment principles, traditional Chinese medicine is adopted for treatment and mainly comprises astragalus membranaceus, codonopsis pilosula, rhizoma atractylodis macrocephalae, radix angelica sinensis, honey-fried licorice roots, poria with hostwood, fried jujube benevolence, radix aconiti carmichaeli, herba epimedii, calcined keel and calcined oysters, other types of medicine are added according to requirements of individuals, and the method comprises the specific steps of soaking the traditional Chinese medicine, decocting the traditional Chinese medicine and taking medicine juice. The method has the advantages that the treatment method can be targeted to pathogenesis, obviously improves the clinical curative effect, is free of toxic or side effect and can benefit more woman patients.

Description

A kind of method for the treatment of climacteric insomnia

Technical field

The present invention relates to climacteric insomnia research field, particularly a kind of method for the treatment of climacteric insomnia.

Background technology

Climacteric is that women is transitioned into the life stage at apogeny age from the reproductive age, refers to, from close to the menopause appearance endocrine relevant with menopause, biology and Clinical symptoms, during 1 year, generally occur between 40-55 years old to last menstruation.The whole world about has 1,500,000 women to step into climacteric every year.Along with the change of life style, work rhythm, climacteric insomnia sickness rate obviously raises.

Climacteric is had a sleepless night, and refers to have a sleepless night to levy patient for climacteric that cardinal symptom is medical is combined.Belong to the category such as the traditional Chinese medical science " before and after menopause all diseases ", " climacteric insomnia ", " being insomnia "." Plain Questions ancient times innocence opinion " physiological process special to this is set forth: " woman ... seventy-seven conception vessels are empty, taichong channel declines few, exhaustion of kidney-essence with promoting reproductive function, menopause, therefore senile appearance and loss of fecundity ".Physiology characteristics, experiences the consume of decades such as " warp, pregnant, product, breasts " and steps into climacteric, life stress in addition, excessive thinking etc., and deficiency of qi and blood, kidney qi degradation, menses will exhaust, easily cause imbalance of YIN and YANG, sun declines can not from secret, and empty sun is more floating, the disturbance mind, malaise, causes the generation of insomnia.

Benefiting QI and nourishing blood method, cures mainly deficiency of qi and blood card, heart storing spirit and main blood, the main think of of spleen and blood of uniting, and the strong then source of generating QI and blood of temper is sufficient, thus painstaking effort are vigorous.Therefore benefiting QI and nourishing blood is invigorating the heart and spleen in fact.GUIPI TANG is the classics side of representative of benefiting QI and nourishing blood method, see the earliest the Song dynasty sternly use and recipes for Saving Lives, former book treatment excessive thinking, impairment caused by overstrain heart spleen, forgetful palpitation with a distress feeling.Medicine forms: the Rhizoma Atractylodis Macrocephalae, Poria cum Radix Pini's (removing wood), the Radix Astragali (going reed), Arillus Longan, Semen Ziziphi Spinosae (fry, shell) each one or two Radix Ginseng, the Radix Aucklandiae (loseing fire) half and half liang of Radix Glycyrrhizae (processing) two money half.Ming Dynasty Xue Li vegetarian adds Radix Angelicae Sinensis, Radix Polygalae on former side basis, then defines the GUIPI TANG adopted so far and all forms.Overall view full side's tool benefiting QI and nourishing blood, the effect of invigorating spleen and nourishing heart.

Wen Qianfa, starts from Zhang Zhongjing, treatise on Febrile Diseases the 118th article " the inverse purgation of fire, because of acupuncture with heated needle agitation person, 'Guizhi Gancao Longgu Muli ' soup master it " in, use warming YANG medicine adds the product of tranquillization with heavy prescription, opens the Wen Qianfa beginning.Modern age, well-known doctor Mr. Wei-Ju ZHU was by long-term clinical practice, then clearly propose the name of " Wen Qian "." Shanghan Zhinan " the 15 " deficiency of vital energy and excited spy notably, medicine should dived with temperature.It is timid for Wen Yizhuan, and diving with flat, it is inverse, let the fire back to its origin, directing fire to its source, the good method of this all Gu, can not because of the excitement of its profile, and the medicine giving excessively taste clearly also ".In medication, often with Radix Aconiti Lateralis Preparata compatibility Magnetitum, think " Radix Aconiti Lateralis Preparata excited, be equipped with Magnetitum, then fresh inverse trouble of overstepping the authority ", " Radix Aconiti Lateralis Preparata is excited, and Magnetitum is calm, and excited 5 is calm, loses its excited calmness and is strong." it is with diseases such as this method Cure for insomnias, effect is distinguished, is to take the course of its own.

The opinions such as climacteric insomnia is not relaxed from stagnation of liver-QI mostly, deficiency of kidney-YIN, disarmony between the heart and kidney, essential resistance of turbid phlegm are controlled, and conventional prescription has XIAOYAO POWDER, LIUWEI DIHUANG WAN, Tianwang Buxin Dan, WEIDANTANG etc.But these Therapeutic Method effects are not remarkable, even if effectively, also repeatedly can there is phenomenon of having a sleepless night, really can not improve the quality of life of patient.

Summary of the invention

The technical problem to be solved in the present invention is to provide the Therapeutic Method that a kind of climacteric that can significantly improve therapeutic effect and improve patients ' life quality is had a sleepless night.

For solving the problems of the technologies described above, technical scheme of the present invention is: a kind of method for the treatment of climacteric insomnia, its innovative point is: close Wen Qianfa for Therapeutic Principle with benefiting QI and nourishing blood, adopt treatment by Chinese herbs, main Chinese medicine comprises the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Glycyrrhizae Preparata, Poria cum Radix Pini, Semen Ziziphi Spinosae (parched), Radix Aconiti Lateralis Preparata, Herba Epimedii, Os Draconis (calcined) and Concha Ostreae (calcined), other Chinese medicines add needed for individual, and concrete steps are as follows:

(1) Chinese medicine is soaked: 30 grams of Radixs Astragali, 20 grams of Radix Codonopsis, 12 grams of Rhizoma Atractylodis Macrocephalaes, 10 grams of Radix Angelicae Sinensis, 12 grams of Radix Glycyrrhizae Preparatas, 15 grams of Poria cum Radix Pinis, 10 grams of Semen Ziziphi Spinosae (parched)s, 6 grams of Radix Aconiti Lateralis Preparatas, 30 grams of Herba Epimedii, 30 grams of Os Draconis (calcined)s and 30 grams of Concha Ostreae (calcined)s are inserted respectively in clear water and soak 1 hour;

(2) decoct Chinese medicine: pulled out by the Chinese medicine of above-mentioned immersion, the Os Draconis (calcined) that is decocted first, Concha Ostreae (calcined) and Radix Aconiti Lateralis Preparata 15 minutes, then add other Chinese medicines, within 30 minutes, decocts once, decoct twice altogether; Decoct twice to obtain medicine juice 400ml;

(3) take medicine juice: the medicine juice of above-mentioned 400ml is divided into two deciles, then sooner or later respectively take medicine juice 200ml after meal twice.

In the present invention, the property of medicine of each crude drug is as follows.

The Radix Astragali: be the root of leguminous plant Radix Astagali or Radix Astragali, the Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.

Radix Codonopsis: Radix Codonopsis has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens the effects such as hemopoietic function.

The Rhizoma Atractylodis Macrocephalae: the Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.

Radix Angelicae Sinensis: it has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation, anticancer, anti-ageing anti-old, immune effect.

Radix Glycyrrhizae Preparata: Radix Glycyrrhizae Preparata contains the number of chemical compositions such as glycyrrhizin, enoxolone, Angelica Polysaccharide, has antiinflammatory and anti-allergy action, scalable body's immunity, antitumor and analgesic effect.

Poria cum Radix Pini: Poria cum Radix Pini is the Chinese medicine product of plant Poria, mind tranquilizing and the heart calming is applicable to the disease such as severe palpitation, insomnia forgetfulness.

Semen Ziziphi Spinosae (parched): it has the effects such as calmness, hypnosis, analgesia, convulsion, cooling.

Radix Aconiti Lateralis Preparata: Radix Aconiti Lateralis Preparata is the daughter root of ranunculaceae plant Aconitum carmichjaelii Debx., and it has recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by effect of wind-cold damp pathogen.

Herba Epimedii: Herba Epimedii has effect of kidney invigorating and YANG supporting, expelling wind and removing dampness, strong muscle key bone.

Os Draconis (calcined): Os Draconis (calcined) has tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, the effect of promoting tissue regeneration and ulcer healing.

Concha Ostreae (calcined): it is astringent or styptic treatment for spontaneous sweating that it has convergence, relieving gastric hyperacidity to alleviate stomachache, tranquillization with heavy prescription, effect of hard masses softening and resolving.

The invention has the advantages that: Therapeutic Method of the present invention, close Wen Qianfa for Therapeutic Principle with benefiting QI and nourishing blood, adopt treatment by Chinese herbs, each Chinese medicine decocting is become medicine juice, patient respectively takes medicine juice 200ml twice sooner or later after meal; This Therapeutic Method, can hit pathogenesis, significantly improves clinical efficacy, and have no side effect, and more can benefit numerous women patient.

Detailed description of the invention

The following examples can make the present invention of professional and technical personnel's comprehend, but therefore do not limit the present invention among described scope of embodiments.

Case selection

Western medicine diagnose standard: works out the definition of climacteric in the diagnostic criteria of climacteric " obstetrics and gynecology " with reference to Le Jie chief editor: before and after menopause, about 40 ~ 55 years old age, after menoxenia or menstruation for the last time in 1 year." CCMD-3 Chinese Spirit Obstacles classification and diagnostic criteria " that the diagnostic criteria of insomnia is worked out with reference to psychiatric department branch of Chinese Medical Association is worked out: (1) is to have a sleepless night for main symptom, comprise have difficulty in going to sleep, insomnia-middle, dreaminess, early awakening, or not easily sleep again after waking up, wake up after sense of discomfort, tired, or daytime sleepiness etc.; (2) sleep quantity quality is discontented with, cause significantly worried or ergasia efficiency to decline, or social function is impaired; (3) at least fall ill 3 times weekly, recurrent exerbation 1 month or more.

Tcm diagnosis standard: disease sees insomnia and dreamful sleep, irritated anxiety, palpitation and dizziness, hypomnesis, shallow complexion, spiritlessness and weakness, hectic fever sweating, but innate deficiency of YANG in the body, winter is afraid of cold, and extremity are not warm, light red tongue, white and thin fur, deep pulse; Dialectical genus deficiency of qi and blood, empty sun is more floating.

Exclusion standard: (1) does not meet above-mentioned diagnostic criteria person; (2) other insomnia secondary (insomnia relevant to mental disorder, sleep disorder caused by sleep disorder, material caused by internal disease), Inadequate sleep hygiene, environmental sleep obstacle, the time difference change syndrome, shift work sleep disorder etc., and sleep apnea syndrome; (3) Bilateral oophorectomy, ovarian tumor or premature ovarian failure person; (4) the serious life-threatening primary diseases such as cardiovascular and cerebrovascular vessel, liver, kidney and hemopoietic system are associated with; (5) other drug or treatment is taken, to the therapeutic effect person of impacting.

Embodiment 1

The Qin, female, 47 years old,

2013-12-06 first visit: repeatedly have a sleepless night half a year, increases the weight of one week.

Closely repeatedly have a sleepless night over the past half year, difficulty falling asleep, sleep night and easily wake up, random dream is diverse and confused, weak, appetite still can, two is just as usual, the soreness of waist; Menstrual cycle is unstable; Pale tongue with thin fur is white, deep pulse.

Give benefiting QI and nourishing blood and close Wen Qianfa, concrete steps are as follows:

(1) Chinese medicine is soaked: 6g gun additioner, 30g Herba Epimedii, 10g Semen Ziziphi Spinosae, 30g are forged dragon

Bone, 30g Concha Ostreae (calcined), the 30g Radix Astragali, 15g Radix Pseudostellariae, 10g Rhizoma Atractylodis Macrocephalae preparata, 10g Radix Angelicae Sinensis, the 15g Cortex Eucommiae, 10g Radix Glycyrrhizae, 10g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) and 10g Spica Prunellae are inserted respectively in clear water and are soaked 1 hour;

(2) Chinese medicine is decocted: pulled out by the Chinese medicine of above-mentioned immersion, the Os Draconis (calcined) that is decocted first, Concha Ostreae (calcined) and big gun

Radix Aconiti Lateralis Preparata 15 minutes, then adds other Chinese medicines, within 30 minutes, decocts once, decocts twice altogether; Decoct twice to obtain medicine juice 400ml;

(3) medicine juice is taken: the medicine juice of above-mentioned 400ml is divided into two deciles, then morning and evening twice meal

After respectively take medicine juice 200ml.

Decocting as stated above and take, 14 days is treatment course for the treatment of.

Further consultation: after taking medicine, sleep quality obviously improves, and former side comes in and goes out and goes on, remove the Rhizoma Pinelliae, Spica Prunellae, add 30g Huai wheat and 10 pieces of Fructus Jujubaes decoct as stated above, decoct to obtain medicine juice 400ml, then sooner or later respectively taking medicine juice 200ml after meal twice, 14 days is treatment course for the treatment of; Further consultation again, patient fully recovers.

Embodiment 2

Button, female, 52 years old,

2014-03-12 first visit: repeatedly have a sleepless night March, very then lies awake all night, the two disease of hand of companion in nearly January, and fear of cold is afraid of cold, time had palpitation, stomach receive still can, two is just as usual, before last menstrual period half a year; Light red tongue is fat, white and thin fur, deep pulse.

Give benefiting QI and nourishing blood and close Wen Qianfa, concrete steps are as follows:

(1) Chinese medicine is soaked: 6g gun additioner, 30g Herba Epimedii, 30g Os Draconis (calcined), 30g Concha Ostreae (calcined), the 30g Radix Astragali, 15g Radix Codonopsis, 10g Rhizoma Atractylodis Macrocephalae preparata, 10g Radix Angelicae Sinensis, 10g Ramulus Cinnamomi, 15g Radix Paeoniae Alba (parched), 10g Semen Ziziphi Spinosae, 10g Radix Glycyrrhizae and 15g Caulis Spatholobi are inserted respectively in clear water and soak 1 hour;

(2) decoct Chinese medicine: pulled out by the Chinese medicine of above-mentioned immersion, the Os Draconis (calcined) that is decocted first, Concha Ostreae (calcined) and gun additioner 15 minutes, then add other Chinese medicines, within 30 minutes, decocts once, decoct twice altogether; Decoct twice to obtain medicine juice 400ml;

(3) take medicine juice: the medicine juice of above-mentioned 400ml is divided into two deciles, then sooner or later respectively take medicine juice 200ml after meal twice.

Decocting as stated above and take, 14 days is treatment course for the treatment of.

Further consultation: have a sleepless night 4-5 hour every night, and disease of hand obviously alleviates, consolidate before continuing, former side adds 10g Rhizoma Gastrodiae, decocts as stated above, decocts to obtain medicine juice 400ml, then sooner or later respectively takes medicine juice 200ml after meal twice, within 14 days, is treatment course for the treatment of; Further consultation again, patient fully recovers.

Embodiment 3

Strongly fragrant certain, female, 50 years old,

2014-03-26 first visit: repeatedly have a sleepless night 1 year, Yi Xing, wake up after be difficult to fall asleep again, dream is many, weak uncomfortable in chest, without the soreness of waist, warms, tinnitus, appetite still can, two just still can, disorderly, through carrying out clot, distending pain of the breast, light red tongue white and thin fur is greasy, deep pulse for menstrual cycle.

Give benefiting QI and nourishing blood and close Wen Qianfa, concrete steps are as follows:

(1) Chinese medicine is soaked: 6g gun additioner, 30g Herba Epimedii, 10g Semen Ziziphi Spinosae, 30g Os Draconis (calcined), 30g Concha Ostreae (calcined), the 30g Radix Astragali, 10g Radix Angelicae Sinensis, 10g Ramulus Cinnamomi, 15g Radix Paeoniae Alba (parched), 12g Fructus Trichosanthis, 10g Rhizoma Cyperi (processed), 30g Magnetitum, 10g Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), 15g Endoconcha Sepiae, 10g Radix Rubiae and 10g Radix Glycyrrhizae are inserted respectively in clear water and soak 1 hour;

(2) decoct Chinese medicine: pulled out by the Chinese medicine of above-mentioned immersion, the Os Draconis (calcined) that is decocted first, Concha Ostreae (calcined), gun additioner and Magnetitum 15 minutes, then add other Chinese medicines, within 30 minutes, decocts once, decoct twice altogether; Decoct twice to obtain medicine juice 400ml;

(3) take medicine juice: the medicine juice of above-mentioned 400ml is divided into two deciles, then sooner or later respectively take medicine juice 200ml after meal twice.

Decocting as stated above and take, 14 days is treatment course for the treatment of.

Further consultation: sleep quality significantly improves, all the other symptoms take a turn for the better, former side's following the service, within 14 days, are treatment course for the treatment of; Further consultation again, patient fully recovers.

Embodiment 4

Contain certain, female, 51 years old

2014-09-12 first visit: insomnia half a year, sleep 1-2 hour often every night, warms battle array and do, sweating, irritated, weakly breathes hard, and appetite is general, and two is just normal, and menstruation is random.Light red tongue, white and thin fur, deep pulse.

Give benefiting QI and nourishing blood and close Wen Qianfa, concrete steps are as follows:

(1) Chinese medicine is soaked: 6g gun additioner, 30g Herba Epimedii, 10g Semen Ziziphi Spinosae, 30g Os Draconis (calcined), 30g Concha Ostreae (calcined), 30g Concha Margaritifera, the 30g Radix Astragali, 15g Radix Pseudostellariae, 10g Rhizoma Atractylodis Macrocephalae preparata, the 15g Radix Rehmanniae, 12g Radix Glycyrrhizae, 30g Huai wheat and 6g Fructus Gardeniae Preparatus are inserted respectively in clear water and soak 1 hour;

(2) decoct Chinese medicine: pulled out by the Chinese medicine of above-mentioned immersion, the Os Draconis (calcined) that is decocted first, Concha Ostreae (calcined), gun additioner and Concha Margaritifera 15 minutes, then add other Chinese medicines, within 30 minutes, decocts once, decoct twice altogether; Decoct twice to obtain medicine juice 400ml;

(3) take medicine juice: the medicine juice of above-mentioned 400ml is divided into two deciles, then sooner or later respectively take medicine juice 200ml after meal twice.

Decocting as stated above and take, 14 days is treatment course for the treatment of.

Further consultation: the length of one's sleep increases, every night about 5 hours, weak improvement, irritated improvement, time have sweating, top defocuses Fructus Gardeniae, adds 12g Radix Ophiopogonis and 10g Fructus Schisandrae Chinensis decocts as stated above, decocting to obtain medicine juice 400ml, then sooner or later respectively take medicine juice 200ml after meal twice, 14 days is treatment course for the treatment of; Further consultation again, patient fully recovers.

Comparative example

Wang, female, 50 years old,

2014-03-26 first visit: repeatedly have a sleepless night 1 year, Yi Xing, wake up after be difficult to fall asleep again, dream is many, weak uncomfortable in chest, without the soreness of waist, warms, tinnitus, appetite still can, two just still can, disorderly, through carrying out clot, distending pain of the breast, light red tongue white and thin fur is greasy, deep pulse for menstrual cycle.

Give western medicine, the oral estazolam tablets of 30min (Jiangsu JumpCan Medicines Co., Ltd., the accurate word of traditional Chinese medicines: H32021079) 1 milligram before patient sleeps every night; Oryzanol tablets (Jiangsu Pengyao Pharmaceutical Co., Ltd., the accurate word of traditional Chinese medicines: H32023637) 20mg, oral, 3 times/d 14 days is a course for the treatment of.

Further consultation: sleep quality increases.

Criterion of therapeutical effect

Sleep quality curative effect judging standard: according to Pittsburgh Sleep Quality Index scale score deduction rate evaluation before and after treatment, is divided into recovery from illness, effective, effective and invalid by sleep quality curative effect.

Total mark × 100% before therapeutic index (n)=(before treatment the rear total mark of total mark-treatment)/treatment,

Recovery from illness: cardinal symptom disappears, integrated value reduces n >=75%;

Effective: cardinal symptom is clearly better, integrated value reduces by 50%≤n<75%;

Effective: cardinal symptom takes a turn for the better, integrated value reduces by 25%≤n<50%;

Invalid: after treatment, cardinal symptom is without taking a turn for the better or increasing the weight of, and integrated value reduces n<25%.

Following table is the Comparison of therapeutic that benefiting QI and nourishing blood of the present invention closes that Wen Qianfa treats and conventional oral estazolam tablets is treated: (all in 60 people)

	Number	Recovery from illness	Effective	Effectively	Invalid	Total effective rate
							The present invention	60	20	25	11	4	93.3%
Tradition	60	7	11	23	19	68.3%

As can be seen from the above table, by the contrast of subject treatment method and traditional therapy, subject treatment method, can hit pathogenesis, significantly improves clinical efficacy, and effective percentage can reach more than 90%.

The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.

Claims (1)

1. treat the method for climacteric insomnia for one kind, it is characterized in that: close Wen Qianfa for Therapeutic Principle with benefiting QI and nourishing blood, adopt treatment by Chinese herbs, main Chinese medicine comprises the Radix Astragali, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Glycyrrhizae Preparata, Poria cum Radix Pini, Semen Ziziphi Spinosae (parched), Radix Aconiti Lateralis Preparata, Herba Epimedii, Os Draconis (calcined) and Concha Ostreae (calcined), other Chinese medicines add needed for individual, and concrete steps are as follows:

(1) Chinese medicine is soaked: 30 grams of Radixs Astragali, 20 grams of Radix Codonopsis, 12 grams of Rhizoma Atractylodis Macrocephalaes, 10 grams of Radix Angelicae Sinensis, 12 grams of Radix Glycyrrhizae Preparatas, 15 grams of Poria cum Radix Pinis, 10 grams of Semen Ziziphi Spinosae (parched)s, 6 grams of Radix Aconiti Lateralis Preparatas, 30 grams of Herba Epimedii, 30 grams of Os Draconis (calcined)s and 30 grams of Concha Ostreae (calcined)s are inserted respectively in clear water and soak 1 hour;

(2) decoct Chinese medicine: pulled out by the Chinese medicine of above-mentioned immersion, the Os Draconis (calcined) that is decocted first, Concha Ostreae (calcined) and Radix Aconiti Lateralis Preparata 15 minutes, then add other Chinese medicines, within 30 minutes, decocts once, decoct twice altogether; Decoct twice to obtain medicine juice 400ml;

(3) take medicine juice: the medicine juice of above-mentioned 400ml is divided into two deciles, then sooner or later respectively take medicine juice 200ml after meal twice.