CN105560127A - 一种天然色素cc霜及其制备方法 - Google Patents
一种天然色素cc霜及其制备方法 Download PDFInfo
- Publication number
- CN105560127A CN105560127A CN201610112851.4A CN201610112851A CN105560127A CN 105560127 A CN105560127 A CN 105560127A CN 201610112851 A CN201610112851 A CN 201610112851A CN 105560127 A CN105560127 A CN 105560127A
- Authority
- CN
- China
- Prior art keywords
- compound
- frost
- phase
- skin
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000049 pigment Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 239000006071 cream Substances 0.000 title abstract description 5
- 238000003756 stirring Methods 0.000 claims description 18
- 239000002994 raw material Substances 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 229940126062 Compound A Drugs 0.000 claims description 6
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims description 6
- JNGZXGGOCLZBFB-IVCQMTBJSA-N compound E Chemical compound N([C@@H](C)C(=O)N[C@@H]1C(N(C)C2=CC=CC=C2C(C=2C=CC=CC=2)=N1)=O)C(=O)CC1=CC(F)=CC(F)=C1 JNGZXGGOCLZBFB-IVCQMTBJSA-N 0.000 claims description 6
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 24
- 241000123113 Phellinus igniarius Species 0.000 abstract description 18
- 239000001054 red pigment Substances 0.000 abstract description 18
- 102000003425 Tyrosinase Human genes 0.000 abstract description 14
- 108060008724 Tyrosinase Proteins 0.000 abstract description 14
- 230000002087 whitening effect Effects 0.000 abstract description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 6
- 230000006870 function Effects 0.000 abstract description 6
- 230000003020 moisturizing effect Effects 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 5
- 239000000758 substrate Substances 0.000 abstract description 5
- 238000012216 screening Methods 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 238000007254 oxidation reaction Methods 0.000 abstract description 3
- 239000000516 sunscreening agent Substances 0.000 abstract description 3
- 230000003647 oxidation Effects 0.000 abstract description 2
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 abstract 1
- 240000008384 Capsicum annuum var. annuum Species 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 239000001511 capsicum annuum Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 239000008271 cosmetic emulsion Substances 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000001953 sensory effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 29
- 238000012360 testing method Methods 0.000 description 19
- 235000002566 Capsicum Nutrition 0.000 description 18
- 241000208293 Capsicum Species 0.000 description 17
- 239000001390 capsicum minimum Substances 0.000 description 17
- 239000000469 ethanolic extract Substances 0.000 description 16
- 238000010521 absorption reaction Methods 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 12
- 239000000523 sample Substances 0.000 description 10
- 238000002835 absorbance Methods 0.000 description 7
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 6
- 238000012423 maintenance Methods 0.000 description 6
- 239000012488 sample solution Substances 0.000 description 6
- -1 Polydimethylsiloxane Polymers 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 239000011703 D-panthenol Substances 0.000 description 4
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 4
- 235000004866 D-panthenol Nutrition 0.000 description 4
- 229960003949 dexpanthenol Drugs 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 3
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 238000000862 absorption spectrum Methods 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- 235000002864 food coloring agent Nutrition 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 210000002752 melanocyte Anatomy 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 229960001679 octinoxate Drugs 0.000 description 3
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 3
- 229960001173 oxybenzone Drugs 0.000 description 3
- 230000019612 pigmentation Effects 0.000 description 3
- 229940108325 retinyl palmitate Drugs 0.000 description 3
- 235000019172 retinyl palmitate Nutrition 0.000 description 3
- 239000011769 retinyl palmitate Substances 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 3
- GVOIABOMXKDDGU-LOFNIBRQSA-N (3S,3'S,5R,5'R)-3,3'-dihydroxy-kappa,kappa-carotene-6,6'-dione Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(=O)C1(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC(=O)C2(C)CC(O)CC2(C)C GVOIABOMXKDDGU-LOFNIBRQSA-N 0.000 description 2
- HOVAGTYPODGVJG-UVSYOFPXSA-N (3s,5r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol Chemical compound COC1OC(CO)[C@@H](O)C(O)[C@H]1O HOVAGTYPODGVJG-UVSYOFPXSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- GVOIABOMXKDDGU-SUKXYCKUSA-N Capsorubin Natural products O=C(/C=C/C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(/C=C/C(=O)[C@@]1(C)C(C)(C)C[C@H](O)C1)\C)/C)\C)/C)[C@@]1(C)C(C)(C)C[C@H](O)C1 GVOIABOMXKDDGU-SUKXYCKUSA-N 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- CMBYOWLFQAFZCP-UHFFFAOYSA-N Hexyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCC CMBYOWLFQAFZCP-UHFFFAOYSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 241001092387 Spiraea Species 0.000 description 2
- 229910010413 TiO 2 Inorganic materials 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 238000004847 absorption spectroscopy Methods 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 230000003712 anti-aging effect Effects 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- XNEFYCZVKIDDMS-UHFFFAOYSA-N avobenzone Chemical compound C1=CC(OC)=CC=C1C(=O)CC(=O)C1=CC=C(C(C)(C)C)C=C1 XNEFYCZVKIDDMS-UHFFFAOYSA-N 0.000 description 2
- 229960005193 avobenzone Drugs 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- LLEMOWNGBBNAJR-UHFFFAOYSA-N biphenyl-2-ol Chemical compound OC1=CC=CC=C1C1=CC=CC=C1 LLEMOWNGBBNAJR-UHFFFAOYSA-N 0.000 description 2
- 235000009132 capsorubin Nutrition 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- VJNCICVKUHKIIV-UHFFFAOYSA-N dopachrome Chemical compound O=C1C(=O)C=C2NC(C(=O)O)CC2=C1 VJNCICVKUHKIIV-UHFFFAOYSA-N 0.000 description 2
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 210000000245 forearm Anatomy 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 229940055726 pantothenic acid Drugs 0.000 description 2
- 239000011713 pantothenic acid Substances 0.000 description 2
- 235000019161 pantothenic acid Nutrition 0.000 description 2
- 239000001688 paprika extract Substances 0.000 description 2
- 235000012658 paprika extract Nutrition 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 230000002000 scavenging effect Effects 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 230000000475 sunscreen effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- GVOIABOMXKDDGU-XRODXAHISA-N (3S,3'S,5R,5'R)-3,3'-dihydroxy-kappa,kappa-carotene-6,6'-dione Chemical compound O=C([C@@]1(C)C(C[C@H](O)C1)(C)C)/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC(=O)[C@]1(C)C[C@@H](O)CC1(C)C GVOIABOMXKDDGU-XRODXAHISA-N 0.000 description 1
- 229940061334 2-phenylphenol Drugs 0.000 description 1
- 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 description 1
- 101710163881 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010012442 Dermatitis contact Diseases 0.000 description 1
- AHMIDUVKSGCHAU-UHFFFAOYSA-N Dopaquinone Natural products OC(=O)C(N)CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-UHFFFAOYSA-N 0.000 description 1
- 240000007833 Dracaena angustifolia Species 0.000 description 1
- 235000009262 Dracaena angustifolia Nutrition 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- AHMIDUVKSGCHAU-LURJTMIESA-N L-dopaquinone Chemical compound [O-]C(=O)[C@@H]([NH3+])CC1=CC(=O)C(=O)C=C1 AHMIDUVKSGCHAU-LURJTMIESA-N 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 239000008681 Phellinus linteus extract Substances 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 244000203593 Piper nigrum Species 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 206010040830 Skin discomfort Diseases 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 230000006750 UV protection Effects 0.000 description 1
- 229930003537 Vitamin B3 Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- 208000002029 allergic contact dermatitis Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- MTZQAGJQAFMTAQ-UHFFFAOYSA-N benzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1 MTZQAGJQAFMTAQ-UHFFFAOYSA-N 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000000342 capsorubin group Chemical group 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 238000012822 chemical development Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- 229960005082 etohexadiol Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229960004502 levodopa Drugs 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000013521 mastic Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000010292 orthophenyl phenol Nutrition 0.000 description 1
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 229940100460 peg-100 stearate Drugs 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000004224 protection Effects 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000036558 skin tension Effects 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
- A61K2800/432—Direct dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
本发明公开了一种天然色素CC霜及其制备方法，是以化妆品乳化理论为基础筛选基质配方，与多种美白活性成分、保湿剂、防晒剂进行复配，并添加桑黄醇提物、辣椒红色素，制备出集遮瑕、美白、保湿、隔离防晒、抗氧化和修护为一体的CC霜。同时对产品的感官指标、理化指标、酪氨酸酶活性抑制、抗氧化、抗炎修护以及防晒等功效进行了研究。
Description
一、技术领域
本发明涉及一种CC霜及其制备方法，具体地说是一种天然色素CC霜及其制备方法。
二、背景技术
Colorcontrolcream简称CC霜，又名色彩调控全效修容霜，顾名思义，CC霜的突出特点就在于其调控肤色能力。与BB霜主打遮瑕、隔离美白相比，CC霜更倾向于敏感问题肌肤、亚健康状态的修复保养，适于长期使用从本质上调整改善肤质肤色。其短期遮瑕效果虽不如BB霜明显，但偏向于清透自然健康的提亮肤色效果；同时倾向于隔离紫外线及灰尘，有效抵御物理性伤害，舒缓肌肤压力。因此，CC霜是一款富含更多营养成分，倾向于防护修容的美妆产品。
人体皮肤颜色主要与皮肤中黑色素的数量、大小、类型及分布有关。黑色素是黑色素细胞内的酪氨酸在酪氨酸酶、多巴色素互变酶和5,6-二羟基吲哚-2-羧酸氧化酶(DHICA氧化酶)三种酶的作用下，氧化成多巴、多巴醌、多巴色素等，最终转化为黑色素颗粒，其中酪氨酸酶起关键性作用。该CC霜配方中添加了维生素C乙基醚和烟酰胺等美白活性成分。维生素C乙基醚能够抑制酪氨酸酶的Cu2+活性，阻断黑色素的形成，改善皮肤色泽；同时还能够促进胶原蛋白产生，增加皮肤弹性，相对普通的维生素C具有极高的稳定性且容易穿透角质层进入真皮层。烟酰胺又名维生素B3，是维生素家庭中重要一员。当黑色素被传递到角质细胞时，皮肤就会看上去变黑，而烟酰胺正是作用于已经产生的黑色素，有效抑制约35％～40％的黑色素从黑色素细胞向角质细胞传递，从而减少过度色素沉积。临床试验证明，使用含有烟酰胺的润肤霜能明显减少皮肤棕色斑点的面积和数量，用肉眼即可分辨出色斑颜色的浅化。
几乎所有的人工合成色素都不能为人体提供营养物质，某些合成色素甚至会危害人体健康。化妆品中所用的色素多数属焦油衍生物，长期使用会对光线发生敏感反应，导致色素沉着，在正常皮肤上出现褐色斑点；色素还是导致人们对化妆品过敏的重要原因之一，常常引起烧灼、瘙痒、表皮剥脱、轻微疼痛等过敏症状，并伴有皮肤潮红、丘疹等炎症现象，严重影响形象，这与人类使用化妆品的初衷背道而驰。本发明的CC霜中以桑黄醇提物和辣椒红色素为着色剂，不含人工合成色素。桑黄醇提物为黄色固体粉末，加入膏霜中可使产品呈亮黄色；其富含黄酮、三萜和酚类等物质，具有抑制酪氨酸酶活性和清除自由基的作用，从而发挥美白抗衰老的功效；桑黄醇提物对UVB、UVA波段具有一定的吸收能力，添加到CC霜中协助防晒剂发挥隔离防晒的功效，间接发挥美白防晒黑的作用；另有文献报道，桑黄作为我国名贵药材，亦具有抗肿瘤、抗炎、增强免疫等作用，因此添加桑黄醇提物到该产品中，在提亮肤色的同时具备了舒缓修护，提高肌肤免疫力的功效。辣椒红色素是一种采用科学方法从辣椒果实中提取、分离、精制而成的天然色素，为深红色油溶性液体，没有辣味，色泽鲜艳，着色力强，耐光、热、酸、碱，且不受金属离子影响。研究表明，辣椒红色素最主要的成分是辣椒红素、辣椒玉红素，同时富含脂肪酸、β-胡萝卜素、维生素E和维生素C等活性物质，具有镇痛、止痒、抗炎、抑菌、脂质过氧化调节、心肌保护、减肥等生理功能和持久的强消炎镇痛作用，现已被广泛应用于食品餐饮、医药工业、饲料等领域，亦可用于化妆品的生产。作为助颜美容成分，辣椒红色素是类胡萝卜素的一种，也是热门的抗氧化剂。
把桑黄醇提物与辣椒红色素作为着色剂添加到发明的产品配方中，与无机纳米二氧化钛共同调配出CC霜的色彩，使得本发明产品不仅具有多种美容功效，且涂抹后肌肤白皙、清透、自然，达到调控色彩、全效修容的效果。
三、发明内容
本发明旨在提供一种天然色素CC霜及其制备方法。本发明以化妆品乳化理论为基础筛选基质配方，与多种美白活性成分、保湿剂、防晒剂进行复配，并添加桑黄醇提物、辣椒红色素，制备出集遮瑕、美白、保湿、隔离防晒、抗氧化和修护为一体的CC霜。同时对产品的感官指标、理化指标、酪氨酸酶活性抑制、抗氧化、抗炎修护以及防晒等功效进行了研究。
本发明天然色素CC霜的原料是由A相、B相、C相、D相及E相构成，各原料配比为：
控制原料总量为100g。
本发明CC霜的制备方法如下：
(1)将A相置于75-80℃水浴锅中搅拌25-30min，使固状物溶解，得到混合料A；将B相中的卡波姆-2020在水中预先分散均匀后再加入B相其它原料，然后置于75-80℃水浴锅中搅拌25-30min，使固状物溶解，得到混合料B；将C、D、E相中各原料分别预先混合搅拌均匀得到混合料C、混合料D及混合料E；
(2)将混合料B、混合料C及混合料D加入到混合料A中，在75-80℃下快速搅拌25-30min，随后开始减速降温，降温至40-45℃时加入混合料E，搅拌均匀，继续降温至30-35℃时停止搅拌，出料，即得CC霜。在降温过程中补加蒸馏水以使成品总质量为100g。
本发明CC霜是O/W(水包油)型乳化体系。该CC霜中添加了月桂酸己酯作为油性成分，更能润滑肌肤，提升产品的质感；绣线菊油是目前已知的最稳定的植物油脂，且具有很高的抗氧化能力，也已被公认具有极高的保湿滋润能力。在油相成分中添加了四种防晒成分阿伏苯宗(丁基甲氧基二苯甲酰基甲烷)、二苯酮-3、甲氧基肉桂酸乙基己酯、TiO2M(100TV)(二氧化钛和氢氧化铝和硬脂酸)。阿伏苯宗在320-400nm有很强的吸收；二苯酮-3在280-360nm有较好吸收；甲氧基肉桂酸乙基己酯是目前应用最为广泛的UVB防护剂，在280-320nm有强吸收；表面处理的纳米TiO2在整个UVB、UVA段都有良好吸收，所以该产品对UVB、UVA区都有很好的防护作用，能够有效避免皮肤受到紫外线的伤害。
本发明CC霜添加D-泛醇、透明质酸钠、维生素C乙基醚、烟酰胺、维生素A棕榈酸酯等活性成分。D-泛醇又被称为维生素原B5，比泛酸更容易渗透进角质层，并在体内迅速转化为泛酸，有较强的保湿作用，有助于舒缓皮肤不适、瘙痒，刺激表皮细胞生长；透明质酸钠能帮助肌肤汲取大量的水分，可瞬间深层保湿、增加皮肤弹性与张力，有助恢复肌肤正常油水平衡，改善干燥及松弛皮肤；维生素C乙基醚是一种亲油亲水的维生素C衍生物，容易穿透角质层进入真皮层，达到深层美白效果，拥有生物利用度很高且性质稳定等特点；烟酰胺是一种水溶性B族维生素，能够有效抑制约35％-40％的黑色素从黑色素细胞向角质细胞传递，减少过度色素沉积从而达到美白作用；维生素A棕榈酸酯具有调节表皮及角质层新陈代谢的功效，作营养成分添加剂，能防止皮肤粗糙，促进正常生长发育，抗衰、去皱。多种保湿、美白成分的添加，使得该款CC霜赋予肌肤不仅是外在的修饰，更是深层的保养和呵护。
本发明添加的桑黄醇提物在200-450nm都具有广泛的紫外-可见光吸收能力(图2)，辣椒红色素在300-550nm也具有广泛的紫外-可见光吸收能力(图3)，二者按不同比例加入产品中，能增强产品的防晒功效，并可调配出与肤色较为接近的偏黄至略微泛红的色泽，完全替代人工合成色素，从而减少对肌肤的刺激作用。
四、附图说明
图1是0.75mg/cm2的CC霜紫外吸收光谱图。
图2是浓度为5.0×10-2mg/mL桑黄醇提物的紫外可见吸收光谱图(溶剂：65vt％乙醇水溶液)。
图3是浓度为2.0mg/mL辣椒红色素的紫外可见吸收光谱图(溶剂：无水乙醇)。
五、具体实施方式
原料说明：
聚二甲基硅氧烷、环五聚二甲基硅氧烷，购自美国MOMENTIVE公司；
PEG-100硬脂酸酯购自英国CRODA公司；
PEG-20甲基葡萄糖苷倍半硬脂酸酯、甲基葡萄糖苷倍半硬脂酸酯，购自杭州德高化工开发有限公司；
十六十八醇(十六醇/十八醇＝22-32/66-76)购自上海倍特化工有限公司；
甲氧基肉桂酸乙基己酯、阿伏苯宗、二苯酮-3、TiO2M(100TV)、C12-15醇苯甲酸酯，购自英国悠立朴华公司；
卡波姆-2020购自美国LUBRIZOL公司；
D-泛醇、维生素C乙基醚、烟酰胺、维生素A棕榈酸酯购自北京贝丽莱斯生物化学有限公司；
透明质酸钠，化妆品级，分子量139万，购自华熙福瑞达生物医药有限公司；
PCG：1,2-辛二醇和2-苯氧基乙醇的混合物，购自南京斯拜科生化实业有限公司；
绣线菊油、月桂酸己酯，购自广州华图化妆品科技有限公司；
桑黄醇提物由六安丹皇生物科技有限责任公司提供；
辣椒红色素由亳州市宇惠天然制品有限公司提供，色价e100。
实施例1：
1、天然色素CC霜的配方如下：
原料总质量为100g。
2、CC霜的制备：
将A相置于75-80℃水浴锅中搅拌25-30min，使固状物溶解，得到混合料A；将B相中的卡波姆-2020在水中预先分散均匀后再加入B相其它原料，然后置于75-80℃水浴锅中搅拌25-30min，使固状物溶解，得到混合料B；将C、D、E相中各原料分别预先混合搅拌均匀得到混合料C、混合料D及混合料E；
将混合料B、混合料C及混合料D加入到混合料A中，在75-80℃下快速搅拌25-30min，随后开始减速降温，降温至40-45℃时加入混合料E，搅拌均匀，继续降温至30-35℃时停止搅拌，出料，即得CC霜。在降温过程中补加蒸馏水以使成品总质量为100g。
3、性能测试
1)感观性能评定
取CC霜在室温和非阳光直射下目测观察膏体是否细腻，色泽是否均匀一致；用嗅觉鉴别气味是否纯正。
2)pH值的测试
称取CC霜样品3g，放入盛有30mL除去CO2的去离子水的烧杯中，在40±1℃下分散均匀。用校正好的pH计测定CC霜水溶液的pH值，测定温度20℃。
3)耐热、耐寒测试
将CC霜样品放置于45℃的恒温烘箱和-10℃的冰箱冷冻室中24h后取出，恢复室温后观察是否有分层、沉淀或出水现象。
4)对酪氨酸酶活性抑制作用
称取CC霜0.25g，用乙醇溶解后配制质量浓度为5mg/mL的待测样品溶液，进行酪氨酸酶活性抑制测试。
分别配置pH＝6.8的磷酸盐缓冲液(PBS)，1mg/mL的L-酪氨酸溶液，0.07mg/mL的酪氨酸酶溶液。按以下设置组加样：A1测试样：2.0mLPBS+2.0mL酪氨酸酶溶液+0.5mLL-酪氨酸溶液；A2测试样：2.5mLPBS+2.0mL酪氨酸酶溶液；A3测试样：0.5mL样品溶液+1.5mLPBS+2.0mL酪氨酸酶溶液+0.5mL-酪氨酸溶液；A4测试样：0.5mL样品溶液+2.0mLPBS+2.0mL酪氨酸酶溶液。混匀，置37℃水浴中保温30min后立即于485nm处测吸光度。根据式(1)计算酪氨酸酶抑制率I：
I＝[1－(A3－A4)/(A1－A2)]×100％(1)；
5)对DPPH·自由基的清除作用
称取CC霜0.25g，用纯水溶解后配制质量浓度为5mg/mL的待测样品溶液，进行抗氧化性测试。
分别取上述待测样品溶液和物质的量浓度为2.00×10-4mol/L的DPPH·乙醇溶液各3mL加入同一具塞试管中，摇匀，避光放置30min后，用紫外-可见分光光度计测定混合溶液在517nm处的吸光度Ai，同时测定3mL的纯水与3mL浓度为2.00×10-4mol/L的DPPH·乙醇溶液混合后的吸光度A0和3mL待测样品溶液与3mL无水乙醇混合后的吸光度Aj，根据式(2)计算清除率P：
P＝[1－(Ai－Aj)/A0]×100％(2)；
6)对皮肤修护作用的测试
在受试者左前臂内侧画三个一元钱币大小的圆圈，将润有适量10％的十二烷基硫酸钠(SDS)水溶液的圆形滤纸片贴敷于画好的圆圈上，轻压使之均匀地贴敷于受试者前臂内侧，并用保鲜膜包住，刺激24小时，取下滤纸片，半小时后观察皮肤变化，拍照并记录。然后一个圆圈内涂抹CC霜，一个圆圈内涂抹不加桑黄醇提物及辣椒红色素的基质霜，另一个圆圈不做任何处理为空白对照，每隔8小时观察记录各圆圈内受损皮肤变化情况，并再次涂抹相应产品，持续观察、操作3次，记录受试部位皮肤的状况变化。
7)CC霜防晒性能的测试
称取适量样品于贴有透气胶带的石英板上，然后戴上指套进行涂抹，涂抹时间不宜过长，但要尽力保证涂抹样品的均匀性，加样量及涂抹后样品剩余量用分析天平进行精确称量。涂抹了防晒样品的载体在常温下水平放置于无光线直射处干燥平衡20min，然后放入紫外-可见分光光度计中在280-400nm进行吸光度测试。
8)桑黄提取物和辣椒红色素的紫外吸收性能测试
以65vt％乙醇水溶液为溶剂，配制5.0×10-2mg/mL桑黄醇提物溶液，测定其在200-500nm处的吸光度。
以无水乙醇为溶剂，配制2.0mg/mL辣椒红色素溶液，测定其在300-600nm处的吸光度。
4、测试结果
1)感官及理化指标测定结果见下表：
2)对酪氨酸酶抑制率
该CC霜浓度5mg/mL时对酪氨酸酶活性抑制率为60.9％，说明样品具有一定的美白作用。
3)对DPPH·自由基的清除率
该CC霜浓度为5mg/mL时对DPPH·自由基的清除率为52.2％，说明样品具有一定的抗氧化性。
4)修护作用
注：圈1涂抹CC霜修复；圈2涂抹基质霜修复；圈3不做任何处理。
在被10％SDS水溶液刺激24h后皮肤红肿脱皮，涂抹本发明的CC霜24h后即可恢复正常；涂抹基质霜24h后消肿，但仍能观察到红斑；不做任何处理的皮肤则恢复较慢；由此说明添加了桑黄醇提物和辣椒红色素的CC霜具有更为明显的修护抗炎功效。
5)CC霜的紫外吸收性能
本发明CC霜的紫外吸收谱图如图1所示，从图中可以看出涂抹法测定的0.75mg/cm2CC霜在280-400nm均有较好吸收，说明其具有广谱防晒性能。
6)桑黄醇提物和辣椒红色素的紫外-可见吸收性能
5.0×10-2mg/mL的桑黄醇提物溶液的紫外-可见吸收谱图见图2，可以看出桑黄醇提物在整个紫外区域都有较好吸收，尤其在UVA区的吸收较强，在可见光区域400-450nm吸收逐渐减弱，最大吸收波长在384nm，加入CC霜中能增强产品的防晒能力，特别提升在UVA区的防护效果。2.0mg/mL的辣椒红色素溶液紫外-可见吸收谱图见图3，可以看出辣椒红色素溶液在可见光区域内400-550nm有强吸收。因此辣椒红色素和桑黄醇提物作为色素原料添加到配方中，不仅可制备出接近亚洲人肤色的CC霜，同时能够增强该产品的吸收紫外线能力，提高产品的防晒效果。
Claims (3)
1.一种天然色素CC霜，其原料是由A相、B相、C相、D相及E相构成，各原料配比为：
控制原料总量为100g。
2.一种权利要求1所述的天然色素CC霜的制备方法，其特征在于包括如下步骤：
(1)将A相置于75-80℃水浴锅中搅拌25-30min，使固状物溶解，得到混合料A；将B相中的卡波姆-2020在水中预先分散均匀后再加入B相其它原料，然后置于75-80℃水浴锅中搅拌25-30min，使固状物溶解，得到混合料B；将C、D、E相中各原料分别预先混合搅拌均匀得到混合料C、混合料D及混合料E；
(2)将混合料B、混合料C及混合料D加入到混合料A中，在75-80℃下快速搅拌25-30min，随后开始减速降温，降温至40-45℃时加入混合料E，搅拌均匀，继续降温至30-35℃时停止搅拌，出料，即得CC霜。
3.根据权利要求2所述的制备方法，其特征在于：
步骤(2)在降温过程中补加蒸馏水以使成品总质量为100g。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610112851.4A CN105560127B (zh) | 2016-02-29 | 2016-02-29 | 一种天然色素cc霜及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610112851.4A CN105560127B (zh) | 2016-02-29 | 2016-02-29 | 一种天然色素cc霜及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105560127A true CN105560127A (zh) | 2016-05-11 |
| CN105560127B CN105560127B (zh) | 2018-07-27 |
Family
ID=55871155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610112851.4A Expired - Fee Related CN105560127B (zh) | 2016-02-29 | 2016-02-29 | 一种天然色素cc霜及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105560127B (zh) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389149A (zh) * | 2016-11-19 | 2017-02-15 | 诺斯贝尔化妆品股份有限公司 | 一种自然滋养修颜霜 |
| CN106983684A (zh) * | 2017-04-05 | 2017-07-28 | 安徽大学 | 一种抗污染霜及其制备方法 |
| CN109528600A (zh) * | 2019-01-18 | 2019-03-29 | 宁夏艾伊生物工程研发有限公司 | 一种气垫cc霜及其制备方法 |
| CN110200874A (zh) * | 2019-07-08 | 2019-09-06 | 卢琛 | 一种美白祛斑霜及其制备方法 |
| CN110464664A (zh) * | 2019-09-12 | 2019-11-19 | 陈晓彤 | 一种天然色素粉底组合物及其制备方法 |
| US20220249347A1 (en) * | 2021-02-10 | 2022-08-11 | TRI-K Industries, Inc. | Composition and Method Containing Pea and Quinoa Natural Peptides And Niacinamide to Enhance Skin Glow, Radiance And Even Skin Tone |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1662217A (zh) * | 2002-06-17 | 2005-08-31 | 宝洁公司 | 多步化妆品有益效果粉底套盒及相关方法 |
| CN103655234A (zh) * | 2013-10-12 | 2014-03-26 | 广州环亚化妆品科技有限公司 | 一种出水型cc霜组合物及其制备方法 |
| CN104586706A (zh) * | 2015-02-13 | 2015-05-06 | 六安市丹皇生物科技有限责任公司 | 一种桑黄防晒霜及其制备方法 |
-
2016
- 2016-02-29 CN CN201610112851.4A patent/CN105560127B/zh not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1662217A (zh) * | 2002-06-17 | 2005-08-31 | 宝洁公司 | 多步化妆品有益效果粉底套盒及相关方法 |
| CN103655234A (zh) * | 2013-10-12 | 2014-03-26 | 广州环亚化妆品科技有限公司 | 一种出水型cc霜组合物及其制备方法 |
| CN104586706A (zh) * | 2015-02-13 | 2015-05-06 | 六安市丹皇生物科技有限责任公司 | 一种桑黄防晒霜及其制备方法 |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389149A (zh) * | 2016-11-19 | 2017-02-15 | 诺斯贝尔化妆品股份有限公司 | 一种自然滋养修颜霜 |
| CN106389149B (zh) * | 2016-11-19 | 2019-08-06 | 诺斯贝尔化妆品股份有限公司 | 一种自然滋养修颜霜 |
| CN106983684A (zh) * | 2017-04-05 | 2017-07-28 | 安徽大学 | 一种抗污染霜及其制备方法 |
| CN106983684B (zh) * | 2017-04-05 | 2020-01-24 | 安徽大学 | 一种抗污染霜及其制备方法 |
| CN109528600A (zh) * | 2019-01-18 | 2019-03-29 | 宁夏艾伊生物工程研发有限公司 | 一种气垫cc霜及其制备方法 |
| CN110200874A (zh) * | 2019-07-08 | 2019-09-06 | 卢琛 | 一种美白祛斑霜及其制备方法 |
| CN110464664A (zh) * | 2019-09-12 | 2019-11-19 | 陈晓彤 | 一种天然色素粉底组合物及其制备方法 |
| US20220249347A1 (en) * | 2021-02-10 | 2022-08-11 | TRI-K Industries, Inc. | Composition and Method Containing Pea and Quinoa Natural Peptides And Niacinamide to Enhance Skin Glow, Radiance And Even Skin Tone |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105560127B (zh) | 2018-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105560127A (zh) | 一种天然色素cc霜及其制备方法 | |
| WO2015135313A1 (zh) | 宝乐果(Borojo)护肤品及其天然保湿、抗衰老、抗紫外、抗过敏和美白的用途 | |
| CN105381007B (zh) | 具有美白功效的外用中药组合物、制剂及其制备方法和用途 | |
| US8298555B2 (en) | Color cosmetic compositions for topical anti-aging skin treatment | |
| TW201438757A (zh) | 抗老化用之皮膚外用組成物及其製造方法 | |
| CN109528603A (zh) | 美白组合物、包含美白组合物的美白亮肤霜及其制备方法 | |
| CN108014045B (zh) | 一种男士护肤组合物及其应用 | |
| CN110623882A (zh) | 一种美白祛斑面膜及其制备方法 | |
| CN102961319B (zh) | 含全天然防晒成分的护肤组合物及其制备方法 | |
| CN106726760A (zh) | 一种眼霜及其制备方法 | |
| CN107242982A (zh) | 一种皙透亮白乳液及其制备方法 | |
| CN103585096A (zh) | 一种活颜紧致精华素及其制备方法 | |
| CN110664644B (zh) | 一种含叶酸的护肤组合物、精华及其制备方法 | |
| EP2942048B1 (en) | Topical compositions comprising a resorcinol and powders | |
| CN103860453B (zh) | 一种活颜紧致润肤霜及其制备方法 | |
| CN110237016A (zh) | 一种具有抗蓝光和修护功效的组合物及其制备方法和应用 | |
| CN108904316A (zh) | 天然美白抗氧化组合物及由其制备的纳米凝胶化妆品 | |
| CN103494719B (zh) | 一种抗衰老面霜的制备方法 | |
| CN109453059A (zh) | 美白化妆品添加剂和美白睡眠面膜及其制备方法 | |
| CN107898737A (zh) | 一种美白保湿化妆品组合物及其制备方法 | |
| CN109106677A (zh) | 一种具有美白功能的组合物及其应用 | |
| CN110721120A (zh) | 一种多功能护肤膏及其制备方法 | |
| CN113693990A (zh) | 一种用于有效抗氧化保湿的组合物及其制备方法与用途 | |
| CN114983840A (zh) | 一种可抵御外界刺激的皮肤屏障修护组合物 | |
| CN110292543A (zh) | 一种替代紫外线吸收剂的生物组合物及其应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180727 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |