CN105557695B - A kind of active ingredient compositions - Google Patents
A kind of active ingredient compositions Download PDFInfo
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- CN105557695B CN105557695B CN201410546500.5A CN201410546500A CN105557695B CN 105557695 B CN105557695 B CN 105557695B CN 201410546500 A CN201410546500 A CN 201410546500A CN 105557695 B CN105557695 B CN 105557695B
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- dithianon
- isoprothiolane
- ingredient compositions
- bactericidal composition
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Abstract
The present invention relates to agriculture field, and in particular to a kind of active ingredient compositions.The invention further relates to a kind of bactericidal composition containing Isoprothiolane and dithianon and its application.A kind of active ingredient compositions of the present invention contain Isoprothiolane and dithianon active ingredient compositions, wherein, the weight ratio of Isoprothiolane and dithianon is 100:1 to 1:100.The invention further relates to a kind of comprising aforesaid active principles in combination thing and agriculturally bactericidal composition of acceptable auxiliary agent and/or carrier, and the purposes of composition prevention or control agricultural disease.
Description
Technical field
The present invention relates to agriculture field, and in particular to a kind of active ingredient compositions.The invention further relates to one kind to contain rice
Bactericidal composition and its application of the pest spirit with dithianon.
Background technology
The preventing and treating of agricultural disease is always the problem of being concerned about the most in agricultural production and be important.The whole Growing season of crop is several
It can all be attacked by various diseases.
Isoprothiolane（Isoprothiolane, Cas RN.50512-35-1）It is a kind of efficient systemic fungicide, sterling is white
Color crystallizes, 54 ~ 54.5 DEG C of fusing point.Solubility is 48mg/L in 20 DEG C of water, is soluble in acetone, benzene, toluene, chloroform, dimethyl methyl
The organic solvents such as acid amides, dimethyl sulfoxide (DMSO), methanol, ethanol, n-hexane.Isoprothiolane can be by each site absorption of crop, and accumulates
To leaf portion tissue, so as to play drug effect, resistance of rainwater washing against, available for preventing and treating rice blast, rice sheath blight disease, culm rot and white
The centering crop disease such as leaf blight.
Dithianon（Dithianon, Cas RN.3347-22-6）Sterling is tan crystals, 225 DEG C of fusing point.It is insoluble in water
With most organic solvents.Dithianon has multiaction mechanism, can be by being breathed with sulfur-containing group reaction and interference cell to press down
A series of fungal enzymes are made, disease death is finally resulted in, while having good protection activity, also there is certain therapeutic activity.Can
Include a kind of fruit, such as apple, pear, etc. and drupe such as apple, pears, peach, apricot, cherry, citrus, grape etc. for various crop fruit tree, prevent and treat most crops and
Fruit diseases such as scab, mildew disease, leaf spot, rust, anthracnose, shot hole, downy mildew, brown rot etc..
CN103734141A disclose a kind of Isoprothiolane and hexaconazole compounding agricultural chemicals suspension agent, its include Isoprothiolane, oneself
Azoles alcohol, surfactant, ethylene glycol, attapulgite, cetanol, the pyridine of acetic acid chloroethene and water, the agricultural chemicals suspension agent, suspensibility
Height, there is strong uptake and translocation effect.
CN103518723A discloses a kind of composition pesticide containing dithianon and Isoprothiolane, is mainly used in anti-harness the river
The fungal diseases such as rice rice blast, it can effectively delay the drug-fast occurrence and development of pathogen.
CN101755759A discloses a kind of bactericidal composition containing dithianon and Fluoxastrobin, wherein dithianon with it is phonetic
The percentage by weight of bacterium ester is 5~60: 40~1, and the composition is used to prevent and treat the multiple diseases on vegetables, is especially suitable for
Prevent and treat vegetables anthracnose, downy mildew, powdery mildew.
CN103168782A discloses a kind of bactericidal composition containing dithianon and triazole class compounds, the weight of the two
It is 5~78 ︰ 2~60 to measure ratio, and the composition is mainly used in preventing and treating anthracnose, spot defoliation, scab, leaf spot, downy mildew
Disease.
Because the environmental requirement to bactericide and economic requirement are constantly improve now, such as to activity profile, toxicity, selection
Property, the requirement of rate of application, residue composition and favourable preparation feasibility, additionally due in terms of such as drug resistance, crop
Healthy aspect there may be problem, and therefore, exploitation is in some aspects lasting appoint better than the new bactericide of existing bactericide
Business.
The content of the invention
The purpose of the present invention is to provide a kind of active ingredient compositions for above-mentioned weak point, to harmful fungoid and bacterium
With good effect and solve the problems, such as the agricultural methods for reducing close rate and/or strengthening activity profile and/or drug resistance management
And composition.
The present inventor have passed through long-term research, finds to compound Isoprothiolane and dithianon, can effectively prevent and treat a variety of
Crop disease, Synergistic.Based on the discovery, inventor completes the present invention.
Just cooperateed with during the activity of compound when the activity of two kinds or more compounds, which exceedes, to be used alone
Synergistic effect.
A kind of active ingredient compositions of the present invention are to take following technical scheme to realize：
Therefore, one aspect of the present invention provides a kind of active ingredient compositions, and the active ingredient compositions contain Isoprothiolane
With dithianon.
In aforesaid active principles in combination thing, the weight ratio of the Isoprothiolane and dithianon is 100:1 to 1:100, especially
It preferably 50:1 to 1:50, preferably 1:20-20:1, more preferably 1:10-10:1, more preferably 1:5-5:Assisted in the range of 1
Same synergistic effect.
Another aspect of the present invention provides a kind of bactericidal composition, wherein the composition includes active component described above
Composition, and agriculturally acceptable auxiliary agent and/or carrier.
Preferably, in a kind of above-mentioned bactericidal composition, the active ingredient compositions are in the bactericidal composition
Weight content is 1wt.% to 80wt.%, preferably 5wt.% to 60wt.%, more preferably 10wt.% to 50wt.%.
A kind of above-mentioned bactericidal composition is prepared into agriculturally acceptable any formulation, wherein be preferably prepared to suspending agent,
Suspended emulsion, seed coat agent, wettable powder, water dispersible granules, microcapsule suspending agent, coated granule, extrusion granule, missible oil,
Microemulsion, aqueous emulsion, effervescent tablet etc..
Above-mentioned formulation is this area regular dosage form, what its preparation method was well known to those skilled in the art, is prepared into
Agricultural agent and/or carrier and its dosage used in above-mentioned various formulations are similarly well-known to those skilled in the art, this
It may refer to for example a bit《Formulations of pesticide process technology》（Liu Bulin is edited, the second edition）.Auxiliary agent used and/or carrier are for example
Including but not limited to solvent, cosolvent, emulsifying agent, dispersant, wetting agent, cyst material, adhesive, film forming agent, disintegrant, increasing
Thick dose, antifreezing agent, stabilizer, pH adjusting agent, warning coloration, filler and/or carrier etc..Those skilled in the art can select it
In one or more auxiliary agents and/or carrier.
For example, when being prepared into suspending agent, following components by weight percent can be included：Active component 1-80%, wetting agent 2-15%,
Dispersant 2-15%, thickener 1-5%, antifreezing agent 1-5%, defoamer 0.1-2%, water surplus；
When being prepared into suspended emulsion, following components by weight percent can be included：Active component 1-80%, solvent 1-30%, emulsification
Agent 2-15%, wetting agent 2-15%, dispersant 2-10%, thickener 1-5%, antifreezing agent 1-5%, defoamer 0.1-2%, water surplus；
When being prepared into wettable powder, following components by weight percent can be included：Active component 1-80%, wetting agent 2-15%,
Dispersant 2-15%, filler surplus；
When being prepared into water dispersible granules, following components by weight percent can be included：Active component 1-80%, wetting agent 2-15%,
Dispersant 2-15%, disintegrant 1-6%, adhesive 1-5%, filler surplus.
Wherein, in above-mentioned formula, the solvent can be selected：Benzene,toluene,xylene, acetone, dimethylformamide,
Dimethyl sulfoxide (DMSO), chloroform, dichloromethane, hexamethylene, cyclohexanone, 1-METHYLPYRROLIDONE, methanol, ethanol, propyl alcohol, isopropyl
It is alcohol, butanol, isobutanol, cyclohexanol, Propylene Glycol ether, ethohexadiol ether, petroleum ether, acetonitrile, paraffin, tetrahydronaphthalene, different
One or more in phorone, soybean oil, cottonseed oil etc.；
The cosolvent can be selected：One or more in methanol, ethanol, isopropanol, n-butanol etc.；
The emulsifying agent can be selected：Lauryl sodium sulfate, neopelex, calcium dodecyl benzene sulfonate,
Thermally coupled distillation columns amine salt, castor oil polyoxyethylene ether phosphate amine salt, three phenethyl phenol polyoxy ether phosphoric acid
Ester amine salt, Polyoxyethylene fatty acid amides fatty acid ester, Fixanol, alkyl isoquinolinium salt, dialkylmorpholinum salts, oleamide sulfonic acid
Salt, diisopropyl naphthalene sulfonate, lignosulfonates, naphthalenesulfonate formaldehyde condensation compound, styryl phenyl APEO, benzene
Ethyl -phenol polyoxyethylene poly-oxygen propylene aether, NPE, AEO, polyoxyethylene alkyl ether,
Polyoxyethylene polyoxypropylene block polymer, alkyl phenol formaldehyde resin polyoxyethylene ether, Polyoxyethylene Sorbitol Fatty Acid Esters, mountain
In pears alcohol acid anhydride monostearate, sorbitan monostearate APEO, polyoxypropylene glycol mono fatty acid ester etc.
It is one or more；
The dispersant can be selected：Lignosulfonates, p-hydroxyphenyl sodium lignin sulfonate, AEO
Sulfate, alkylnaphthalene sulfonate, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, dodecyl trimethyl ammonium salt, alkyl dimethyl benzyl ammonium
Salt, two polyoxyethylene lauryl ether phosphate, styrene-maleic acid salt copolymer, aliphatic alcohol polyoxyvinethene phosphate, nonyl
Base phenol polyethenoxy ether, glycerine fatty acid APEO, polyoxyethylene alkylaryl ether, polyoxyethylene lanolin alcohol, polyoxy
In ethene sorbitan aliphatic ester, polyoxyethylene glyceryl mono fatty acid ester, alkylolamides and polyoxyethylene alkyl amine etc.
One or more；
The wetting agent can be selected：Lauryl sodium sulfate, calcium dodecyl benzene sulfonate, isooctanol succinate sulfonic acid
Sodium, oleoyl methyl sodium taurocholate, polyoxyethylene lauryl ether carboxylic acid sodium, sodium N-lauroyl sarcosinate, N- lauroyl paddy ammonia
Sour sodium, dioctyl sulfosuccinate, polyoxyethylene alkylaryl ether phosphate ester salt, trisiloxanes APEO, triphen second
The poly- base ether formaldehyde contracting of base phenol APEO, castor oil polyoxyethylene ether, AEO, alkylphenol-polyethenoxy
Compound, alkylphenol-polyethenoxy base ether phosphate, polyoxyethylene fatty acid ester, higher fatty acid ester, sorbitan fatty
One or more in acid esters etc.；
Described adhesive can be selected：It is starch, polyvinylpyrrolidone, carboxymethyl cellulose, carboxyethyl cellulose, bright
One or more in glue, Arabic gum, xanthans etc.；
The film forming agent can be selected：Polyvinyl alcohol, polyvinyl acetate, polyacrylamide, carboxymethyl cellulose, hydroxypropyl
One or more in base cellulose, Arabic gum, gelatin, xanthans, starch etc.；
The disintegrant can be selected：Urea, sodium sulphate, calcium sulfate, sodium acid carbonate, ammonium sulfate, magnesium chloride, sodium chloride etc.
In one or more；
The thickener can be selected：Arabic gum, xanthans, gelatin, polyvinyl alcohol, aluminium-magnesium silicate, carboxymethyl cellulose
One or more in plain sodium etc.；
The defoamer can be selected：One or more in butylphosphoric acid ester, phosphoric acid isobutyl ester, n- octanol, silicone etc.；
The antifreezing agent can be selected：One or more in ethylene glycol, propane diols, glycerine etc.；
The stabilizer can be selected：Triphenyl phosphite, N- soybean oleyl trimethylene diamine, dialkyl group succinate
One or more in sulfonate, epoxychloropropane, butyl glycidyl ether etc.；
The warning coloration can be selected：Basic rhodamine, alkaline purple 10, alkalescence purple 49, CI 45430, acid red 52, acid
One or more in property red 14, acid blue 9, acid yellow 23, alkali red 1:1 0, alkali red 1:1 08；
The preservative can be selected：One or more in benzoic acid, sodium benzoate etc.；
The pH adjusting agent can be selected：Hydrochloric acid, calgon, sodium citrate, sodium acid carbonate, sodium hydroxide, hydrogen-oxygen
One or more in agent, triethanolamine etc.；
The filler and/or carrier can be selected：Attapulgite, diatomite, kaolin, white carbon, bentonite, illiteracy are de-
One or more in stone, calcium carbonate, zeolite, acid clay, carclazyte, pyrophyllite, talcum, calcite etc..
Another aspect of the present invention provides aforesaid active principles in combination thing or bactericidal composition is used to prevent or control agricultural disease
Harmful purposes.
The present invention also provides a kind of method prevented or control agricultural disease, by aforesaid active principles in combination thing or sterilization group
Compound acts on target useful plant, pathogenic bacteria or its environment, the propagating materials of target useful plant.
Wherein, the target useful plant that inventive compound composition or bactericidal composition are applicable includes but is not limited to：
Rice, wheat, corn, barley, rye, oat, sorghum, cotton, soybean, red bean, Kidney bean, peanut, buckwheat, beet, rape, to
Day certain herbaceous plants with big flowers, sugarcane, tobacco, eggplant, tomato, Chinese prickly ash, potato, cucurbita pepo, cucumber, pumpkin, watermelon, wax gourd, pumpkin, radish, major part
Dish, Chinese cabbage, wild cabbage, leaf mustard, broccoli, cauliflower, burdock, garland chrysanthemum, jerusalem artichoke, romaine lettuce, shallot, onion, garlic, asparagus, Hu
Radish, caraway, celery, spinach, pea, Swiss chard, rape etc..Inventive compound composition or bactericidal composition are suitable to anti-
The agriculture disease fungus controlled includes but is not limited to：
Mastigomycotina fungi, such as knee Pseudomonas (Plasmodiophora), section Chytridium (Physoderma), water mold
Belong to (Saprolegnia), Achyla (Achlya), pythium (Pythium), Phytophthora (Phytophthora), Peronospora
(Peronospora), Pseudoperonospora (Pseudoperonospora), Plasmopara (Plasmopara), Bremia
(Bremia), the fungi such as Sclerospora (Sclerospora)；
Zygomycotina fungi, for example, rhizopus (Rhizopus), mucor (Mucor), Absidia (Absidia),
The fungies such as Choanephora (Choanephora)；
Ascomycotina fungi, such as Exoascus (Taphrina), Eurotiale (Eurotiales), aspergillus
(Aspergillus), Penicillium (Penicillium), Blumeria (Blumeria), Sphaerotheca
(Sphaerotheca), Podosphaera (Podosphaera, Erysiphe (Erysiphe), Microsphaera
(Microsphaera), Uncinula (Uncinula), Phyllactinia (Phyllactinia), long beak shell category
(Ceratocystis), Gibberella (Gibberella), Valsa (Valsa), mycosphaerella (Mycosphaerella),
(Monilinia, Invisible element are for ball Cuo Pseudomonas (Guignardia), Venturia (Venturia), chain sclerotinia sclerotiorum belong
Monilia), the fungi such as Sclerotinia (Sclerotinia)；
Basidiomycotina fungi, such as Puccinia (Puccinia), glue Rust (Gymnosporangium), grid rust
Pseudomonas (Melampsora), Phakopsora (Phakopsora), Ustilago (Ustilago), Tilletia
(Tilletia), axle Ustilago (Sphacelotheca), every load ear category (Septobasidium), Exobasidium
(Exobasidium) fungies such as lead fungi category (Thanatephorus), Armillaria (Armillaria), are died；
Deuteromycotina fungi, such as Rhizoctonia (Rhizoctonia), sclerotium (Sclerotium), clump stalk spore
Belong to (Monilia), powder spore category (Oidium), Botrytis (Botrytis), Ramularia (Ramularia), Pyricularia Sacc.
(Pyricularia), Penicillium (Penicillium), aspergillus (Aspergillus), Verticillium (Verticillium,
Cercospora (Cercospora), Alternaria, Cladosporium (Cladosporium), Fusicladium (Fusicladium), interior navel are compacted
The diseases such as spore category (Drechslera), Bipolaris (Bipolaris), prominent navel Helminthosporium (Exserohilum).
Specifically, the specific plant disease and cause of disease that inventive compound composition or bactericidal composition are suitable to preventing and treating are true
Bacterium includes but is not limited to：
Rice disease：Rice blast (grey pears spore (Pyricularia grisea)), long compacted spore leaf spot (palace portion cochliobolus
(Cochliobolus miyabeanus)), banded sclerotial blight (Rhizoctonia solani Kuhn (Rhizoctonia solani)) and bakanae disease (rattan
Storehouse is red mould (Gibberella fuj ikuroi))；
Barley, wheat, oat and rye disease：Powdery mildew (standing grain powdery mildew (Blumeria graminis)), head blight
(F.graminearum schw (Fusarium graminearum), oat fusarium (F. avenacerum), machete fusarium (F.
Culmorum), F. asiatricum, the rotten microtorr bacterium (Microdochium nivale) of snow), rust (bar shaped handle rest fungus
(Puccinia striiformis), puccinia graminis (P. graminis), wheat leaf rust germ (P. recondite), barley
Handle rest fungus (P. hordei)), snow blight (Typhula sp., Micronectriella nivalis), smut
(Ustilago tritici), bunt (Tilletia caries (Tilletia caries)), eye spot (wheat-based
Maize ear rot bacterium (Pseudocercosporella herpotrichoides)), barley leaf blotch (rye beak spore
(Rhynchosporium secalis)), wheat moire disease (wheat leaf blight bacterium (Septoria tritici)), glume blight
(the withered spherical cavity bacterium (Leptosphaeria nodorum) of grain husk) and net blotch (Pyrenophora teres Drechsler)；
Maize diseases：The leaf blight of corn (the prominent compacted spore bacterium of navel (Exserohilum turcicum)), corn southern leaf blight (beautiful another name for Sichuan Province
Broomcorn millet Bipolaris sacchari (Bipolaris maydis)), corn rust (Puccina sorghi (Puccinia sorghi))；
Tomato disease：Early blight (rope Lan Shi rod methods (Alternaria solani)), leaf mold (cladosporium fulvum
(Cladosporium fulvum)), late blight (phytophthora infestans (Phytophthora infestans)), gray leaf spot (eggplant crawl
Handle it is mould (Stemphylium solani))；
Cucumber disease：(Pseudoperonospora Cuba is false for gray mold (Botrytis cinerea (Botrytis cinerea)), cucumber downy mildew
Downy mildew (Pseudoperonospora cubensis)), powdery mildew of cucumber (monofilament shell powdery mildew
(Sphaerothecafuliginea)), cucumber anthracnose (Curcurbitaceae colletotrichum (Colletotrichum orbiculare))；
Cotton disease：Fusariumsp wilt disease (Fusarium oxysporum (Fusarium oxysporum)), samping off (miliary damping-off
Bacterium (Rhizoctonia solani Kuhn (Rhizoctonia solani)), verticillium wilt (Verticilliumdahliae (Verticillium dahlia))；
Rape disease：Sclerotiniose (sclerotinite (Sclerotinia sclerotiorum)), black spot (black spot of cabbage chain
Lattice spore (Alternaria brassicae)), powdery mildew (Erysiphe cichoracearum), balck shank
(Leptosphaeria maculans)；
Eggplant disease：Brown spot (brown line Phomopsis (Phomopsis vexans)) and powdery mildew (Erysiphe
cichoracearum)；
Brassicaceous vegetable disease：Interlinkage bag category leaf spot (Alternaria japonica), Leucoplakia (overgrown with weeds bluish white spot
Germ (Cercosporella brassicae)), clubroot (plasmodiophora brassicae (Plasmodiophora brassicae)) and
Downy mildew (Peronospora parasitic (Peronospora parasitica))；
Shallot disease：Rust (green onion handle rest fungus (Puccinia allii))；
Beans disease：Purple seed pinta (Kikuchi tail spore (Cercospora kikuchii), scab circle spore category shot hole
(Elsinoe glycines), pod blight and cane blight (Diaporthe phaseolorum var. sojae), rust
(Phakopsora pachyrhizi), stem rot (soybean phytophthora (Phytophthora sojae)), gray mold (Botrytis cinerea
Mould (Botrytis cinerea), sclerotiniose (Sclerotinia sclero tiorum)；
Kidney bean disease：Gray mold (Botrytis cinerea (Botrytis cinerea), sclerotiniose (Sclerotinia
Sclero tiorum), anthracnose (Colletotrichum lindemthianum)；
Peanut disease：Leaf spot (Cercosporapersonata bacterium (Cercospora personata)), brown leaf spot (peanut tail spore bacterium
(Cercospora arachidicola)) and southern blight (Sclerotium rolfsii (Sclerotium rolfsii))；
Beet disease：Cercospora leaf spot (beet tail spore (Cercospora beticola)), leaf blight
(Thanatephorus cucumeris), root rot (Aphanomyces cochlioides)；
Pea disease：Powdery mildew (pea powdery mildew (Erysiphe pisi))；
Potato disease：Early blight (rope Lan Shi rod methods (Alternaria solani)), late blight (phytophthora infestans
(Phytophthora infestans)), pink rot (Phytophthora erythroseptica), powdery scab
(Spongospora subterranean f. sp. subterranea) and rhizoctonia disease (Rhizoctonia solani)；
Tobacco diseases：Brown spot (Alternarialongipes (Alternaria longipes)), powdery mildew (two spore powdery mildews
(Erysiphe cichoracearum)), anthracnose (Colletotrichum tabacum), downy mildew (peronospora tabacina
(Peronospora tabacina)) and late blight (Phytophthora nicotianae).
Term " propagating materials of target useful plant " be interpreted as referring to it is all have the plant part of fertility, such as plant
Son, fruit, stem tuber or kernel or plant cutting.
Reactive compound Isoprothiolane and dithianon can be administered simultaneously, or apply respectively, or sequential application, during separate administration
Order on the result of preventing and treating generally without influence.
The active ingredient compositions or bactericidal composition of the present invention can be administered to it by conventional methods, such as be carried out
Pouring, spraying, atomizing, broadcast sowing, dust, and the powder as processing dry seed, dry mixing powder, moist seed dressing, wet-mixing kind, slurries
Seed dressing, the solution for handling seed, the water solube powder for handling seed, the water solube powder of processing soil, or pass through and to be formed
Shell etc..
When using the active ingredient compositions or bactericidal composition of the present invention,
During-usual processing plant parts, the rate of application of active ingredient compositions is usually 0.1 to 10000g/ha, preferably
For 10 to 1000g/ha;
During seed dressing, the rate of application of active ingredient compositions is 0.001 to 50g/kg seeds, preferably 0.01 to 10g/kg
Seed；
- for soil treatment：The rate of application of active ingredient compositions is usually 0.1-10000 g/ha, preferably 1-5000
g/ha。
Above-mentioned dosage is only general exemplary dose, and those skilled in the art can be according to actual feelings when reality is applied
Condition and needs, rate of application is adjusted especially in accordance with the seriousness of the property and germ of pending plant or crop.
A kind of bactericidal composition of the present invention, has good effect to harmful fungoid and bacterium and solves reduction close rate
And/or the agricultural methods and composition of the problem of enhancing activity profile and/or drug resistance management.
A kind of bactericidal composition of the present invention compounds Isoprothiolane and dithianon, can effectively prevent and treat various crop disease,
With Synergistic.Just occur during the activity of compound when the activity of two kinds or more compounds, which exceedes, to be used alone
Synergistic function.
Embodiment
The present invention is further described with reference to specific embodiment, but does not limit the invention to these tools
Body embodiment.One skilled in the art would recognize that present invention encompasses may include in Claims scope
All alternatives, improvement project and equivalents.
（One）Example of formulations
In following example of formulations, unless otherwise indicated, the percentage is weight percentage.
The dithianon water-dispersion granule of 1 10% Isoprothiolane of embodiment+50%
Being formulated composition is：Isoprothiolane 10%, dithianon 50%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 10%, trisiloxanes polyoxy
Vinethene 5%, ammonium sulfate 5%, Arabic gum 5%, bentonite surplus；
Preparation method is：The above-mentioned each component of formula ratio is weighed respectively, and is mixed, is granulated, and water dispersible granules are made.
The dithianon water-dispersion granule of 2 25% Isoprothiolane of embodiment+5%
Being formulated composition is：Isoprothiolane 25%, dithianon 5%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, castor oil polyoxyethylene
Ether 8%, ammonium sulfate 5%, xanthans 5%, kaolin surplus；
Preparation method is：The above-mentioned each component of formula ratio is weighed respectively, and is mixed, is granulated, and water dispersible granules are made.
The dithianon suspending agent of 3 20% Isoprothiolane of embodiment+2%
Being formulated composition is：Isoprothiolane 20%, dithianon 2%, p-hydroxyphenyl sodium lignin sulfonate 9%, triphenoethyl benzene phenol gather
Oxygen vinethene 5%, Arabic gum 5%, ethylene glycol 5%, silicone 0.5%, water surplus；
Preparation method is：The above-mentioned each component of formula ratio is weighed, by ultramicro grinding method, suspending agent is made.
The dithianon suspending agent of 4 2% Isoprothiolane of embodiment+20%
Being formulated composition is：Isoprothiolane 2%, dithianon 20%, polyoxyethylene glyceryl mono fatty acid ester 9%, oleoyl methyl
Sodium taurocholate 7%, Arabic gum 5%, ethylene glycol 5%, silicone 0.5%, water surplus；
Preparation method is：The above-mentioned each component of formula ratio is weighed, by ultramicro grinding method, suspending agent is made.
The dithianon wettable powder of 5 40% Isoprothiolane of embodiment+2%
Being formulated composition is：Isoprothiolane 40%, dithianon 2%, polyoxyethylene alkyl amine 12%, the poly- base of alkylphenol-polyethenoxy
Ether formaldehyde condensation products 6%, kaolin surplus；
Preparation method is：The above-mentioned each component of formula ratio is weighed, and is mixed, grinds, crushes, wettable powder is made
Agent.
The dithianon wettable powder of 6 2% Isoprothiolane of embodiment+40%
Being formulated composition is：Isoprothiolane 2%, dithianon 40%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, polyxyethylated virtue
Base ether phosphate 8%, kaolin surplus；
Preparation method is：The above-mentioned each component of formula ratio is weighed, and is mixed, grinds, crushes, wettable powder is made
Agent.
The dithianon suspended emulsion of 7 10% Isoprothiolane of embodiment+0.1%
Being formulated composition is：Isoprothiolane 10%, dithianon 0.1%, dimethyl sulfoxide (DMSO) 8%, neopelex 6%, ten
Dialkyl group leptodactyline 4%, AEO 5%, Arabic gum 3%, glycerine 4%, n- octanol 0.5%, water surplus；
Preparation method is：Preparation method is：By the Isoprothiolane of formula ratio, solvent, emulsifying agent, antifreezing agent, thickener, defoaming
Agent and suitable quantity of water mixing, obtain aqueous emulsion；The dithianon of formula ratio, dispersant, wetting agent and suitable quantity of water are mixed simultaneously
It is sanded, obtains suspension；The water of above-mentioned aqueous emulsion, suspension and surplus is mixed, stirred, obtains the breast that suspends
Agent.
The dithianon suspended emulsion of 8 0.1% Isoprothiolane of embodiment+10%
Being formulated composition is：Isoprothiolane 0.1%, dithianon 10%, acetone 1%, neopelex 4%, nonyl phenol gather
Oxygen vinethene 6%, N- sodium lauroyl glutamates 4%, Arabic gum 5%, glycerine 4%, n- octanol 0.5%, water surplus；
Preparation method is：Preparation method is：By the Isoprothiolane of formula ratio, solvent, emulsifying agent, antifreezing agent, thickener, defoaming
Agent and suitable quantity of water mixing, obtain aqueous emulsion；The dithianon of formula ratio, dispersant, wetting agent and suitable quantity of water are mixed simultaneously
It is sanded, obtains suspension；The water of above-mentioned aqueous emulsion, suspension and surplus is mixed, stirred, obtains the breast that suspends
Agent.
The dithianon microcapsule suspension-suspendinagent agent of 9 1% Isoprothiolane of embodiment+50%
By poly methylene poly phenyl poly isocyanate（PAPI）, Isoprothiolane and SOLVESSOTM200 oil phases formed add
Containing ATLOXTMIn 4913 aqueous solution, emulsion is formed.Then heat and be incubated 50oCatalyst reaction is added under C 2 hours.
The microcapsules of Isoprothiolane is obtained after cooling.
ATLOXTM4913, dispersant LFH, defoamer, urea, dithianon and water mix in proportion, and through sand
Mill, is prepared into suspending agent.
Will obtained Isoprothiolane microcapsules add dithianon aqueous suspension agent in, be uniformly mixing to obtain 2% Isoprothiolane+
50% dithianon microcapsule suspension-suspendinagent agent.
The dithianon suspension seed-coating agent of 10 50% Isoprothiolane of embodiment+1%
Above-mentioned each component is mixed in proportion, and through being sanded, is prepared into suspension seed-coating agent.
The active ingredient compositions of embodiment 11
Isoprothiolane 20%
Dithianon 80%
Above-mentioned active component is mixed in proportion.
Above example proportioning is weight per distribution ratio.
（Two）Biological test
1st, rice blast fungus are tested
For trying disease fungus：Pyricularia oryzae (grey pears spore (Pyricularia grisea))
Test method：Virulence of the medicament to disease fungus is determined using growth rate method.Specifically, medicament is made into 1000
Mg/L mother liquor, then take and mixed in right amount according to the predetermined ratio of table 1 and use the 2% Tween 80 aqueous solution to prepare 5 concentration gradients,
Then add into 45-50 DEG C of PDA culture medium, be well mixed and pour into the culture dish of sterilizing, formed after cooling with poison
Base plane is cultivated, clear water is blank control, and each concentration is repeated 3 times.Afterwards, by pathogen spore suspension（Concentration about 1 × 106
It is individual）5 μ l are instilled on above-mentioned each culture base plane, and culture dish is placed in into 25 DEG C, cultivated 96 hours in the incubator of humidity 90%.So
Afterwards, culture dish is taken out, measures colony diameter, and suppression growth rate of each chemicals treatment to germ is calculated by following formula, and is obtained
EC of each processing to pathogen50。
Then, according to the abundant methods of Sun Yun by the EC of each processing of measure50It is converted into actual poison exponent (ATI)；According to mixture
Proportioning, calculate theoretical toxicity index (TTI), by following equation calculate mixture co-toxicity coefficient (CTC), as a result see the table below 1.
=
If co-toxicity coefficient is more than 120, show there is synergistic effect；Co-toxicity coefficient is less than 80, is shown to be antagonism；Poison system altogether
Number is shown to be summation action between 100-120.
The Isoprothiolane of table 1 compounds the Toxicity Determination result to Pyricularia oryzae with dithianon
The data of table 1 are not difficult to find out, after Isoprothiolane compounds with dithianon, 100：1 to 1:In the range of 100, show
Go out synergy.
2nd, bacterium of downy mildew of cucumber is tested
For trying disease fungus：Bacterium of downy mildew of cucumber (Pseudoperonospora cubensis)
Test method：Virulence of the medicament to disease fungus is determined using growth rate method.Specifically, medicament is made into 1000
Mg/L mother liquor, then take and mixed in right amount according to the predetermined ratio of table 2 and use the 2% Tween 80 aqueous solution to prepare 5 concentration gradients,
Then add into 45-50 DEG C of PDA culture medium, be well mixed and pour into the culture dish of sterilizing, formed after cooling with poison
Base plane is cultivated, clear water is blank control, and each concentration is repeated 3 times.Afterwards, by pathogen spore suspension（Concentration about 1 × 106
It is individual）5 μ l are instilled on above-mentioned each culture base plane, and culture dish is placed in into 25 DEG C, cultivated 96 hours in the incubator of humidity 90%.So
Afterwards, culture dish is taken out, measures colony diameter, and suppression growth rate of each chemicals treatment to germ is calculated by following formula, and is obtained
EC of each processing to pathogen50.Then, according to the abundant methods of Sun Yun by the EC of each processing of measure50It is converted into actual poison exponent
(ATI)；According to the proportioning of mixture, theoretical toxicity index (TTI) is calculated, the co-toxicity coefficient (CTC) of mixture is calculated by following equation,
As a result 2 be see the table below（Computational methods are same as above）.
The Isoprothiolane of table 2 compounds the Toxicity Determination result to Pseudoperonospora cubensis with dithianon
The data of table 1 are not difficult to find out, after Isoprothiolane compounds with dithianon, 100：1 to 1:In the range of 100, show
Go out synergy.
（Three）Field control effectiveness test
Determine the field efficacy of the present composition and single dose to cucumber anthracnose.50 square metres of plot area, 4 weights
It is multiple.Dispenser is investigated after handling 7 days using random five point sampling, as a result see the table below 3.
Disease scale standard is as follows：
0 grade：Disease-free spot；
1 grade：Lesion area accounts for less than the 5% of whole leaf area；
3 grades：Lesion area accounts for the 6% ~ 15% of whole leaf area；
5 grades：Lesion area accounts for the 16% ~ 25% of whole leaf area；
7 grades：Lesion area accounts for the 26% ~ 50% of whole leaf area；
9 grades：Lesion area accounts for more than the 50% of whole leaf area.
Preventive effect computational methods are：
The result of table 3 shows that Isoprothiolane is with that after dithianon compounding, relative to each single dose, can significantly improve to cucumber charcoal
The preventive effect of subcutaneous ulcer disease.
A kind of bactericidal composition of the present invention is described by specific embodiment.But examples detailed above is only
The present invention is explained further, is not limitation of the invention, by simply adjust such scheme to obtain
The scheme arrived, without departing from the spirit of the present invention, it is regarded as being included within the scope of the present invention.
Claims (12)
- A kind of 1. active ingredient compositions, it is characterised in that containing Isoprothiolane and dithianon, the Isoprothiolane and dithianon Weight ratio be 100:1 to 1:100.
- 2. active ingredient compositions according to claim 1, it is characterised in that the weight of the Isoprothiolane and dithianon Than for 50:1 to 1:50.
- 3. active ingredient compositions according to claim 1, it is characterised in that the weight of the Isoprothiolane and dithianon Than for 20:1 to 1:20.
- 4. active ingredient compositions according to claim 1, it is characterised in that the weight of the Isoprothiolane and dithianon Than for 10:1 to 1:10.
- 5. active ingredient compositions according to claim 1, it is characterised in that the weight of the Isoprothiolane and dithianon Than for 5:1 to 1:5.
- 6. a kind of bactericidal composition, it is characterised in that the bactericidal composition includes the active ingredient combinations described in claim 1 Thing, and agriculturally acceptable auxiliary agent and/or carrier.
- 7. a kind of bactericidal composition according to claim 6, it is characterised in that the active ingredient compositions kill described Weight content in bacteria composition is 1wt.% to 80wt.%.
- 8. a kind of bactericidal composition according to claim 6, it is characterised in that the active ingredient compositions kill described Weight content in bacteria composition is 5wt.% to 60wt.%.
- 9. a kind of bactericidal composition according to claim 6, it is characterised in that the active ingredient compositions kill described Weight content in bacteria composition is 10wt.% to 50wt.%.
- 10. a kind of bactericidal composition according to claim 6, it is characterised in that the bactericidal composition is prepared into agriculture Acceptable suspending agent, aqueous emulsion, microemulsion, water dispersible granules, wettable powder, suspension seed-coating agent, granule, micro-capsule in industry Suspending agent.
- 11. the active ingredient compositions of claim 1 or the bactericidal composition of claim 6 are used to prevent or control agricultural disease Purposes.
- A kind of 12. method prevented or control agricultural disease, by the active ingredient compositions or claim described in claim 1 Bactericidal composition described in 6 acts on target useful plant, pathogenic bacteria or its environment, the propagating materials of target useful plant.
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| CN101795566A (en) * | 2007-09-07 | 2010-08-04 | 巴斯夫欧洲公司 | Co-crystals of pyrimethanil and dithianon |
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| CN1668198A (en) * | 2002-07-18 | 2005-09-14 | 巴斯福股份公司 | Fungicidal mixtures |
| CN101795566A (en) * | 2007-09-07 | 2010-08-04 | 巴斯夫欧洲公司 | Co-crystals of pyrimethanil and dithianon |
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