CN105547969A - Helicobacter pylori tester - Google Patents
Helicobacter pylori tester Download PDFInfo
- Publication number
- CN105547969A CN105547969A CN201510979594.XA CN201510979594A CN105547969A CN 105547969 A CN105547969 A CN 105547969A CN 201510979594 A CN201510979594 A CN 201510979594A CN 105547969 A CN105547969 A CN 105547969A
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- CN
- China
- Prior art keywords
- helicobacter pylori
- geiger
- circuit
- signal conditioning
- control circuit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 241000590002 Helicobacter pylori Species 0.000 title claims abstract description 35
- 229940037467 helicobacter pylori Drugs 0.000 title claims abstract description 35
- 230000003750 conditioning effect Effects 0.000 claims abstract description 19
- 230000029058 respiratory gaseous exchange Effects 0.000 claims abstract description 10
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000003990 capacitor Substances 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 14
- 108090000790 Enzymes Proteins 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 239000004202 carbamide Substances 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 210000001156 gastric mucosa Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 208000007882 Gastritis Diseases 0.000 description 2
- 108010046334 Urease Proteins 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 230000005250 beta ray Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 210000000080 chela (arthropods) Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001952 enzyme assay Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229910052754 neon Inorganic materials 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention provides a helicobacter pylori tester. The helicobacter pylori tester comprises a high-voltage power supply module, a Geiger counting circuit, a signal conditioning circuit, a control circuit and a respiration card, wherein the Geiger counting circuit comprises a Geiger counter; the high-voltage power supply module is connected with the Geiger counter through a first resistor and a second resistor; one path of signal is led out between the first resistor and the second resistor; the signal accesses the signal conditioning circuit through a capacitor; the signal conditioning circuit is connected with the control circuit. The helicobacter pylori tester has the beneficial effects of simple structure, easiness in operation and capability of rapidly and accurately detecting helicobacter pylori.
Description
Technical field
The present invention relates to tester, particularly a kind of helicobacter pylori tester.
Background technology
Human infection helicobacter pylori can cause stomach trouble, indigestion, ulcer, even canceration.
Existing, the method that helicobacter pylori detects is a lot, comprises the direct inspection of bacterium, uremic enzyme assay, immunology detection and polymerase chain reaction etc.
(1) the direct inspection of bacterium: get gastric mucosa (mostly being antrum) by gastrocopy pincers, then do smear, dyeing, detect after tissue section strain and microbe growth.Gastric mucosa microbe growth is the most reliable method of diagnosing helicobacter pylori, can be used as the goldstandard of other diagnostic tests of checking, can carry out drug sensitive test again simultaneously, instruct Clinical Selection medicine.
(2) uremic enzyme checks: because helicobacter pylori is the bacterium that uniquely can produce a large amount of uremic enzyme in people's stomach, therefore carrys out diagnosing helicobacter pylori by detecting uremic enzyme.Uremic enzyme decomposes uremic in stomach and generates ammonia and carbon dioxide, makes urea concentration reduction, ammonia density rising.Multiple detection method has been developed: 1. gastric biopsy uremic enzyme test based on this principle; 2. breathalyse; 3. gastric juice urea or determination of urea nitrogen; 4. 15N-urea test.
(3) immunology detection: existing panimmunity detection method at present, detect helicobacter pylori by the pylori spiral bacilli antibody measured in serum, comprise complement fixation test (CFT), agglutination test, passive hemagglutination mensuration, immunoblot assay and enzyme Joint adsorption mensuration etc.
(4) polymerase chain reaction technique: normal gastric mucosa seldom detects helicobacter pylori (0 ~ 6%), the recall rate of Patients with Chronic Gastritis helicobacter pylori is very high, about 50% ~ 80%, chronic active gastritis patient helicobacter pylori recall rate is then higher, reaches more than 90%.
Among these detection methods, breathalyse belongs to the type of ease of Use.
Summary of the invention
In order to solve above-mentioned existing technical matters, the invention provides a kind of helicobacter pylori tester, its structure is simple, easy to operate, can detect helicobacter pylori fast and accurately.
The present invention solves above-mentioned existing technical matters, provides a kind of helicobacter pylori tester, comprises high-voltage power module, Geiger counter circuit, signal conditioning circuit, control circuit and breathing card; Described Geiger counter circuit comprises Geiger tube; Described high-voltage power module connects described Geiger tube through the first resistance, the second resistance; Between described first resistance and described second resistance, draw a road signal, this signal accesses described signal conditioning circuit through an electric capacity; Described signal conditioning circuit is connected with described control circuit.
Further improvement of the present invention is as described below.
Described Geiger tube is flat structure.
Described Geiger tube is two, just to be arrangeding in parallel; Described breathing card can insert/extract out between two Geiger tubes.
Described signal conditioning circuit comprises pre-amplifier, high-speed comparator, Schmidt trigger and monostable circuit; Described pre-amplifier, high-speed comparator, Schmidt trigger and monostable circuit are linked in sequence.
Comprise display module, load module, described display module, load module are connected with described control circuit respectively.
Described control circuit comprises print.er port and USB port.
Compared to prior art, the invention has the beneficial effects as follows: structure is simple, easy to operate, helicobacter pylori can be detected fast and accurately.
Accompanying drawing explanation
Fig. 1 is the circuit diagram of Geiger counter circuit of the present invention.
Fig. 2 is the circuit diagram of signal conditioning circuit of the present invention.
Fig. 3 is the block scheme of helicobacter pylori tester of the present invention.
Geiger counter circuit 11 Geiger tube 111
Signal conditioning circuit 12 pre-amplifier 121
High-speed comparator 122
Schmidt trigger 123
Monostable circuit 124
Control circuit 13 print.er port 131
USB port 132
Display module 14
Load module 15
Embodiment
Illustrate below in conjunction with accompanying drawing and embodiment the present invention is further described.
As shown in Figure 1 to Figure 3, a kind of helicobacter pylori tester, comprises high-voltage power module, Geiger counter circuit 11, signal conditioning circuit 12, control circuit 13 and breathes card.Geiger counter circuit 11 comprises Geiger tube 111; High-voltage power module connects Geiger tube 111 through the first resistance, the second resistance; Between the first resistance and the second resistance, draw a road signal, this signal is through an electric capacity access signal conditioning circuit 12; Signal conditioning circuit 12 is connected with control circuit 13.
The principle of work of this helicobacter pylori tester is: suppose human infection helicobacter pylori, and namely there is helicobacter pylori in the stomach of so human body, helicobacter pylori can produce urease in stomach.When the urea that human oral C marks, the urease in human stomach becomes making urea decomposition the gas marked containing C.Generally, after oral 30 minutes, suck and breathe card, make the C that contains breathed out mark gas absorption in breathing card surface.
Breathing sticker is located at Geiger tube 111, and so, Geiger tube 111 will be caught breathing card adsorption C under high voltages and be identified radiogenic β ray.The β ray entered in Geiger tube 111 causes the ionized inert gas in Geiger tube 111, ionized gas is under the effect of highfield, negative ion accelerates the anode movement to Geiger tube 111, by the collision with other gas molecule, cause again more ionisation of gas, produce a large amount of charged ions instantaneously, Geiger tube 111 produces a negative pulse that can detect.This negative pulse is through the conditioning of signal conditioning circuit 12, and last input control circuit 13 counts, and can measure C mark, thus judge testee's situation.
For the ease of breathing the insertion of card, Geiger tube 111 of the present invention is flat structure, such as: this Geiger tube 111 to be interior diameters be 446# stainless steel right cylinder of 44.5 millimeters, high 15.5 millimeters, is filled with Duo Qi Ti – neon in right cylinder.This Geiger tube 111 is two, just to be arrangeding in parallel; Breathe card can insert/extract out between two Geiger tubes 111.
Signal conditioning circuit 12 of the present invention comprises pre-amplifier 121, high-speed comparator 122, Schmidt trigger 123 and monostable circuit 124; Pre-amplifier 121, high-speed comparator 122, Schmidt trigger 123 and monostable circuit 124 are linked in sequence, pulse signals can carry out shaping and broadening and Geiger tube 111 output pulse signal and amplify through pre-amplifier 121, be defeated by high-speed comparator 122 and carry out wave shaping, the undersuing of formation standard, form positive pulse signal by Schmidt trigger 123 again, finally give monostable circuit 124 stretched pulse.
Helicobacter pylori tester of the present invention comprises display module 14, load module 15, and display module 14, load module 15 are connected with control circuit 13 respectively, conveniently carries out optimum configurations to control circuit 13, analyzes testing result.Meanwhile, facilitate the use of this tester, control circuit 13 comprises print.er port 131 and USB port 132.
Helicobacter pylori tester of the present invention needs local demarcation, before namely using, first tests background ray under the test environment, need deduct this background ray during actual test.Background demarcates the ray value of namely testing and not placing when breathing card.Then, carry out insert breathe card test, obtain test value, contrastive test value and standard value, if test value standard value ± 20% scope in, then show that this tester can normally work.
Tester structure of the present invention is simple, easy to operate, can detect helicobacter pylori fast and accurately.
Above content is in conjunction with concrete preferred implementation further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, all should be considered as belonging to protection scope of the present invention.
Claims (6)
1. a helicobacter pylori tester, is characterized in that: comprise high-voltage power module, Geiger counter circuit, signal conditioning circuit, control circuit and breathing card;
Described Geiger counter circuit comprises Geiger tube; Described high-voltage power module connects described Geiger tube through the first resistance, the second resistance;
Between described first resistance and described second resistance, draw a road signal, this signal accesses described signal conditioning circuit through an electric capacity;
Described signal conditioning circuit is connected with described control circuit.
2. helicobacter pylori tester according to claim 1, is characterized in that: described Geiger tube is flat structure.
3. helicobacter pylori tester according to claim 2, is characterized in that: described Geiger tube is two, just to be arrangeding in parallel; Described breathing card can insert/extract out between two Geiger tubes.
4. helicobacter pylori tester according to claim 3, is characterized in that: described signal conditioning circuit comprises pre-amplifier, high-speed comparator, Schmidt trigger and monostable circuit; Described pre-amplifier, high-speed comparator, Schmidt trigger and monostable circuit are linked in sequence.
5. the helicobacter pylori tester according to Claims 1-4 any one, is characterized in that: comprise display module, load module, and described display module, load module are connected with described control circuit respectively.
6. the helicobacter pylori tester according to Claims 1-4 any one, is characterized in that: described control circuit comprises print.er port and USB port.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510979594.XA CN105547969A (en) | 2015-12-23 | 2015-12-23 | Helicobacter pylori tester |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510979594.XA CN105547969A (en) | 2015-12-23 | 2015-12-23 | Helicobacter pylori tester |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105547969A true CN105547969A (en) | 2016-05-04 |
Family
ID=55827311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510979594.XA Pending CN105547969A (en) | 2015-12-23 | 2015-12-23 | Helicobacter pylori tester |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105547969A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113311008A (en) * | 2021-06-22 | 2021-08-27 | 安徽乐众生医疗科技有限公司 | Visual multi-functional helicobacter pylori detector |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1180997A (en) * | 1995-04-11 | 1998-05-06 | 内斯托尔体系Ab | Device for detecting components in exhaled air |
| CN102338757A (en) * | 2010-07-26 | 2012-02-01 | 深圳市中核海得威生物科技有限公司 | Helicobacter pylori 14C detection device and method |
| CN203490372U (en) * | 2013-08-30 | 2014-03-19 | 安徽养和医疗器械设备有限公司 | Breath card detector |
| CN104049077A (en) * | 2014-06-27 | 2014-09-17 | 安徽养和医疗器械设备有限公司 | Helicobacter pylori detector |
-
2015
- 2015-12-23 CN CN201510979594.XA patent/CN105547969A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1180997A (en) * | 1995-04-11 | 1998-05-06 | 内斯托尔体系Ab | Device for detecting components in exhaled air |
| CN102338757A (en) * | 2010-07-26 | 2012-02-01 | 深圳市中核海得威生物科技有限公司 | Helicobacter pylori 14C detection device and method |
| CN203490372U (en) * | 2013-08-30 | 2014-03-19 | 安徽养和医疗器械设备有限公司 | Breath card detector |
| CN104049077A (en) * | 2014-06-27 | 2014-09-17 | 安徽养和医疗器械设备有限公司 | Helicobacter pylori detector |
Non-Patent Citations (2)
| Title |
|---|
| 唐建东: "基于C8051F982的幽门螺旋杆菌测试仪的设计与实现", 《电子技术》 * |
| 马永健 等: "插卡式幽门螺杆菌(Hp)测试仪的研制", 《现代科学仪器》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113311008A (en) * | 2021-06-22 | 2021-08-27 | 安徽乐众生医疗科技有限公司 | Visual multi-functional helicobacter pylori detector |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160504 |