CN105536041A - Royal jelly acid containing antibacterial biological dressings as well as preparation method and application thereof - Google Patents
Royal jelly acid containing antibacterial biological dressings as well as preparation method and application thereof Download PDFInfo
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
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- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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Abstract
The invention discloses royal jelly acid containing antibacterial biological dressings as well as a preparation method and application thereof. One of the antibacterial biological dressings comprises the following ingredients in percentage by weight: 0.01-20% of royal jelly acid, 0.01-1% of a stabilizer, 1-5% of chitosan, alginate, polyving akohol or collagen and the balance of a matrix, wherein the stabilizer is alkyl trimethyl ammonium salt, multi-alkyl dimethyl ammonium salt or a betaine-type surfactant. Through the combination of royal jelly acid with one or more of chitosan, alginate, polyving akohol and collagen, a series of the antibacterial biological dressings of the solution/solvent type, the gel type, the cream type, the dressing type, the powder type and the patch type are prepared, can be used for treating infectious wounds, surgical wounds, burn wounds, scald wounds and the like, and are good in antibacterial property and broad in application prospect. The antibacterial biological dressings are reasonable in formula and convenient to prepare, and can control wound infection, keep the wounds wet and promote wound healing. More than one hundred of clinical cases prove that the effective rate of the antibacterial biological dressings reaches 95% or above.
Description
Technical field
The present invention relates to a kind of biomedical material, particularly relate to a kind of antibacterial biological dressing, preparation method and its usage containing Royal Jelly acid, be applicable to various trauma care.
Background technology
The developing direction of current wound dressing experienced by three phases: the first stage, and passive-type dressing (traditional dressing) is as defat cotton yarn, absorbent carbasus, synthetic fibers etc.Traditional dressing is passive to be covered on wound surface, absorbs exudate, for wound surface provides limited protective effect; Second stage, the dressing of interaction type, as macromolecule membrane, polymeric foam dressing, hydrogel and bearing hydrocolloid dressing, the interaction of various ways is there is between the dressing of interaction type and wound surface, as absorbed transudate and noxious substance, allow gas exchange, thus create a desirable environment for wound healing; Barrier layer structure, prevents microorganism in environment from invading, the cross infection of prevention wound surface; Phase III, the dressing of biological activity type, as chitosan dressing, alginate dressing, argentiferous medical dressing etc., biological active dressing self has the active release that maybe can promote active substance, there is antibacterial, hemostasis, pain relieving, the short effect such as more, to burn, wound, surgical wound, ulcer, decubital ulcer, there is good effect.
As novel biological activity type dressing, chitosan, alginate are due to difference and the production technology difference of originating, and difference in quality is large, and anti-microbial property also difference is larger.Silver-containing antibacterial dressing in the market makes a big difference in the structure and form etc. of the kind of silver compound and addition, carrier material, and the final products performance produced also has a great difference.In general, the anti-microbial property of the dressing that silver content is higher is also stronger, but silver itself is not the minor metallic element that needed by human body is wanted, the silver being absorbed into human body from wound enters the circulation of human body by blood, and is distributed to liver, kidney, brain, eyes and other organs.Clinical have been found that when the concentration of silver ion solution is more than 1% to human cell tissue be harmful to.Silver nitrate uses maximum silver salt, but the NO in silver nitrate
3 -certain murder by poisoning is had, the healing of the wound that slows down, and NO to wound and cell
3 -easily be reduced to NO
2 -, inducing cell generation canceration.Nano silver antibacterial material is applied to medicine and hygiene fields inevitably will relate to biosafety issues, and the research such as Chen Dandan finds that the accumulation degree of nanometer silver at animal viscera is far away higher than micron silver, proves that nanometer silver has potential bad biological effect.Therefore research is a kind of safe and reliable, and the dressing of good anti-bacterial effect is significant.
Because the defect that above-mentioned existing dressing exists, the present inventor is based on being engaged in the practical experience and Professional knowledge that this type of product design manufacture enriches for many years, and coordinate the utilization of scientific principle, actively in addition research and innovation, to founding a kind of novel antibacterial biological dressing, preparation method and its usage containing Royal Jelly acid, it is made to have more practicality.Through constantly research, design, and through repeatedly studying sample and after improving, finally creating the present invention had practical value.
Summary of the invention
Main purpose of the present invention is, overcomes the defect that existing dressing exists, and provides a kind of novel antibacterial biological dressing, preparation method and its usage containing Royal Jelly acid, improves anti-microbial property, thus is more suitable for practicality, and have the value in industry.
The object of the invention to solve the technical problems realizes by the following technical solutions.According to the antibacterial biological dressing containing Royal Jelly acid that the present invention proposes, be grouped into by the one-tenth of following percentage by weight: 0.01 ~ 20% Royal Jelly acid, 0.01 ~ 1% stabilizing agent, 1 ~ 5% chitosan, alginate, polyvinyl alcohol or collagen protein, surplus is substrate; Described stabilizing agent is alkyl trimethyl ammonium salt, many alkyl dimethyls ammonium salt or betaine type amphoteric surfactant.
The aforesaid antibacterial biological dressing containing Royal Jelly acid, the dosage form of described dressing is the substrate that solution dosage or dressing type adopt is purified water.
The aforesaid antibacterial biological dressing containing Royal Jelly acid, the dosage form of described dressing is the substrate that gel preparations adopts is carbomer, cellulose or polyvinyl alcohol.
The aforesaid antibacterial biological dressing containing Royal Jelly acid, the dosage form of described dressing is cream type, and the matrix components of employing is grouped into by the one-tenth of following weight portion,
The aforesaid antibacterial biological dressing containing Royal Jelly acid, the dosage form of described dressing is pad pasting dosage form, and the matrix components of employing is the one in zinc sulfate, PVA05-88, PVA17-88, CMC-Na, polyvinyl alcohol or gelatin.
Containing the preparation method of the antibacterial biological dressing of Royal Jelly acid, comprise following operating procedure, after Royal Jelly acid, stabilizing agent and chitosan, alginate, polyvinyl alcohol or collagen protein a kind of mixed dissolution wherein, be dissolved in substrate, then fill is in packing container, after irradiation sterilization, obtain solution dosage dressing, gel preparations dressing or the dressing of cream type.
The preparation method of the aforesaid antibacterial biological dressing containing Royal Jelly acid, is sprayed on absorbent carbasus, cotton pad or synthetic fibers by the solution dosage dressing of preparation, and after drying, stripping and slicing, encapsulation, after irradiation sterilization, obtains the dressing of dressing type.
The preparation method of the aforesaid antibacterial biological dressing containing Royal Jelly acid, is ground into fine powder, subpackage by the one in Royal Jelly acid and chitosan, alginate, polyvinyl alcohol or collagen protein, after irradiation sterilization, obtains powder-type dressing.
The preparation method of the aforesaid antibacterial biological dressing containing Royal Jelly acid, after Royal Jelly acid, stabilizing agent and chitosan, alginate, polyvinyl alcohol or collagen protein a kind of mixed dissolution wherein, merge with substrate, masking on film applicator, dry, packaging after cutting, irradiation sterilization, obtains the dressing of pad pasting dosage form.
Containing the various wound surface that the antibacterial biological dressing of Royal Jelly acid causes for the protection of burn, wound, operation, infection, control traumatic infection, maintenance wound surface are moistening, wound healing.
By technique scheme, the present invention at least has following advantages containing the antibacterial biological dressing of Royal Jelly acid, preparation method and its usage:
Royal Jelly acid (10-HDA) also claim E-10-hydroxy-2-decylenic acid, and only having just containing Royal Jelly acid in Lac regis apis at occurring in nature, is the unsaturated fatty acid that occurring in nature uniquely exists in Lac regis apis.Royal Jelly acid is the rare material regulating general immunity function, and can match in excellence or beauty with penicillin to the antibacterial action of staphylococcus, escherichia coli, Bacillus proteus and Hemolytic streptococcus.The present invention combines the antibacterial biological dressing series making solution dosage, gel preparations, cream type, dressing type, powder-type, pad pasting dosage form by one or more in Royal Jelly acid and chitosan/alginate/polyvinyl alcohol/collagen protein, may be used for treatment infected wound, surgical wound, various burn and scald wounds etc., anti-microbial property is good, has broad application prospects.Formula of the present invention is reasonable, easy to prepare, controls traumatic infection, keeps wound surface moistening, wound healing, and through 100 many cases clinical case checkings, effective percentage reaches more than 95%.
Above-mentioned explanation is only the general introduction of technical solution of the present invention, in order to better understand technological means of the present invention, and can be implemented according to the content of description, be described in detail as follows below with preferred embodiment of the present invention.
Detailed description of the invention
For further setting forth the present invention for the technological means reaching predetermined goal of the invention and take and effect, to the antibacterial biological dressing containing Royal Jelly acid proposed according to the present invention, its detailed description of the invention of preparation method and its usage, feature and effect thereof, be described in detail as follows.
Embodiment 1
The present invention, containing the antibacterial biological dressing of Royal Jelly acid, is grouped into by the one-tenth of following weight percents:
Solution dosage preparation method: after Royal Jelly acid, stabilizing agent and chitosan mixed dissolution, miscible in purified water, fill, in plastic bottle, after irradiation sterilization, is finished product.
The various wound surface that product causes for the protection of burn, wound, operation, infection, control traumatic infection, maintenance wound surface are moistening, wound healing.During use, be sprayed at the surface of wound surface.
Embodiment 2
The present invention, containing the antibacterial biological dressing of Royal Jelly acid, is grouped into by the one-tenth of following weight percents:
Gel preparations preparation method: after Royal Jelly acid, stabilizing agent and collagen protein mixed dissolution, miscible in polyvinyl alcohol matrix, fill, in plastic tube, after irradiation sterilization, is finished product.During use, be applied in the surface of wound surface.
Embodiment 3
The present invention, containing the antibacterial biological dressing of Royal Jelly acid, is grouped into by the one-tenth of following weight percents:
Wherein matrix components is grouped into by the one-tenth of following weight portion:
Cream type preparation method: by Royal Jelly acid, stabilizing agent, with alginate mixed dissolution after, miscible in substrate, fill, in plastic tube, after irradiation sterilization, is finished product.During use, be applied in the surface of wound surface.
Embodiment 4
The present invention, containing the antibacterial biological dressing of Royal Jelly acid, is grouped into by the one-tenth of following weight percents:
Dressing type preparation method: after Royal Jelly acid, stabilizing agent and chitosan mixed dissolution, miscible in purified water, fill, in plastic bottle, after irradiation sterilization, is sprayed at by solution-type dressing on the materials such as absorbent carbasus, cotton pad or synthetic fibers and makes, be finished product.
Embodiment 5
The present invention, containing the antibacterial biological powder-type dressing of Royal Jelly acid, does not contain stabilizing agent and substrate; During preparation, Royal Jelly acid and collagen protein are ground into fine powder, subpackage, after irradiation sterilization, obtain product.
Embodiment 6
The present invention, containing the antibacterial biological dressing of Royal Jelly acid, is grouped into by the one-tenth of following weight percents:
The preparation method of pad pasting dosage form dressing: Royal Jelly acid, stabilizing agent, alginate and substrate are merged, masking on film applicator, dry, cut into the fritter of 1.5cm*2.0cm, packaging, after irradiation sterilization, obtains product.
Antibacterial experiment shows that product has certain bacteriostasis to escherichia coli, bacillus subtilis, staphylococcus aureus, and along with the increase of concentration, bacteriostasis strengthens.More responsive to escherichia coli under same concentration, bacillus subtilis, staphylococcus aureus take second place.0.625mg/ml, 1.25mg/ml, 2.5mg/ml are respectively to the minimum inhibitory concentration of escherichia coli, bacillus subtilis, staphylococcus aureus.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, although the present invention discloses as above with preferred embodiment, but and be not used to limit the present invention, any those skilled in the art, do not departing within the scope of technical solution of the present invention, make a little change when the technology contents of above-mentioned announcement can be utilized or be modified to the Equivalent embodiments of equivalent variations, in every case be the content not departing from technical solution of the present invention, according to any simple modification that technical spirit of the present invention is done above embodiment, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (10)
1., containing an antibacterial biological dressing for Royal Jelly acid, it is characterized in that: be grouped into by the one-tenth of following percentage by weight: 0.01 ~ 20% Royal Jelly acid, 0.01 ~ 1% stabilizing agent, 1 ~ 5% chitosan, alginate, polyvinyl alcohol or collagen protein, surplus is substrate; Described stabilizing agent is alkyl trimethyl ammonium salt, many alkyl dimethyls ammonium salt or betaine type amphoteric surfactant.
2. the antibacterial biological dressing containing Royal Jelly acid according to claim 1, is characterized in that: the dosage form of described dressing is the substrate that solution dosage or dressing type adopt is purified water.
3. the antibacterial biological dressing containing Royal Jelly acid according to claim 1, is characterized in that: the dosage form of described dressing is the substrate that gel preparations adopts is carbomer, cellulose or polyvinyl alcohol.
4. the antibacterial biological dressing containing Royal Jelly acid according to claim 1, is characterized in that: the dosage form of described dressing is cream type, and the matrix components of employing is grouped into by the one-tenth of following weight portion,
5. the antibacterial biological dressing containing Royal Jelly acid according to claim 1, is characterized in that: the dosage form of described dressing is pad pasting dosage form, and the matrix components of employing is the one in zinc sulfate, polyvinyl alcohol or gelatin.
6. the preparation method containing the antibacterial biological dressing of Royal Jelly acid, it is characterized in that: comprise following operating procedure, after Royal Jelly acid, stabilizing agent and chitosan, alginate, polyvinyl alcohol or collagen protein a kind of mixed dissolution wherein, be dissolved in substrate, then fill is in packing container, after irradiation sterilization, obtain solution dosage dressing, gel preparations dressing or the dressing of cream type.
7. the preparation method of the antibacterial biological dressing containing Royal Jelly acid according to claim 6, is characterized in that: be sprayed on absorbent carbasus, cotton pad or synthetic fibers, after drying by the solution dosage dressing of preparation, stripping and slicing, encapsulation, after irradiation sterilization, obtains the dressing of dressing type.
8. the preparation method of the antibacterial biological dressing containing Royal Jelly acid according to claim 6, it is characterized in that: the one in Royal Jelly acid and chitosan, alginate, polyvinyl alcohol or collagen protein is ground into fine powder, subpackage, after irradiation sterilization, obtains powder-type dressing.
9. the preparation method of the antibacterial biological dressing containing Royal Jelly acid according to claim 6, it is characterized in that: after Royal Jelly acid, stabilizing agent and chitosan, alginate, polyvinyl alcohol or collagen protein a kind of mixed dissolution wherein, merge with substrate, masking on film applicator, dry, packaging after cutting, irradiation sterilization, obtains the dressing of pad pasting dosage form.
10., containing the various wound surface that the antibacterial biological dressing of Royal Jelly acid causes for the protection of burn, wound, operation, infection, control traumatic infection, maintenance wound surface are moistening, wound healing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610041705.7A CN105536041A (en) | 2016-01-21 | 2016-01-21 | Royal jelly acid containing antibacterial biological dressings as well as preparation method and application thereof |
Applications Claiming Priority (1)
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| WO2019018997A1 (en) | 2017-07-25 | 2019-01-31 | 惠州华阳医疗器械有限公司 | Antimicrobial alginate fibre, and preparation method for and use of dressing thereof |
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| CN112426562A (en) * | 2020-11-27 | 2021-03-02 | 河南汇博医疗股份有限公司 | Pure natural medical dressing for promoting wound healing |
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