CN105535992B - Ascl1在诱导星形胶质细胞转分化为功能性神经元中的应用 - Google Patents

Ascl1在诱导星形胶质细胞转分化为功能性神经元中的应用 Download PDF

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CN105535992B
CN105535992B CN201510662939.9A CN201510662939A CN105535992B CN 105535992 B CN105535992 B CN 105535992B CN 201510662939 A CN201510662939 A CN 201510662939A CN 105535992 B CN105535992 B CN 105535992B
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cells
astrocytes
ascl1
mcherry
aav
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CN105535992A (zh
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程乐平
章晓辉
刘月光
缪庆龙
袁嘉成
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Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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CN201510662939.9A 2014-10-17 2015-10-14 Ascl1在诱导星形胶质细胞转分化为功能性神经元中的应用 Active CN105535992B (zh)

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CN2014105551157 2014-10-17
CN201510662939.9A CN105535992B (zh) 2014-10-17 2015-10-14 Ascl1在诱导星形胶质细胞转分化为功能性神经元中的应用

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Publication number Priority date Publication date Assignee Title
CN110305846A (zh) * 2018-03-20 2019-10-08 中山大学中山眼科中心 视网膜节细胞的制备方法
CN111073855A (zh) * 2018-10-19 2020-04-28 中国科学院上海生命科学研究院 诱导星形胶质细胞转分化为五羟色胺能神经元的方法及应用
CN111484977B (zh) * 2019-01-25 2023-05-16 中国科学院脑科学与智能技术卓越创新中心 重编程产生功能性去甲肾上腺素能神经元的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102796696A (zh) * 2011-05-27 2012-11-28 复旦大学附属华山医院 一种从人皮肤细胞直接诱导的神经元细胞及其制备方法

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US9057053B2 (en) * 2010-01-19 2015-06-16 The Board Of Trustees Of The Leland Stanford Junior University Direct conversion of cells to cells of other lineages
WO2013025963A2 (fr) * 2011-08-17 2013-02-21 President And Fellows Of Harvard College Conversion de cellules somatiques en motoneurones spinaux fonctionnels, et procédés et utilisations associés
CN103773771A (zh) * 2013-11-28 2014-05-07 南京医科大学 一种转录因子组及其制备方法、应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102796696A (zh) * 2011-05-27 2012-11-28 复旦大学附属华山医院 一种从人皮肤细胞直接诱导的神经元细胞及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Mash1 efficiently reprograms rat astrocytes into neurons";Daofang Ding 等;《NEURAL REGENERAT10N RESEARCH》;20140131;第9卷;第26-30页，"结果"与"讨论" *
"Mash1在室管膜前下区神经干细胞向神经元分化中的作用";张治元 等;《中华神经医学杂志》;20060531;第5卷(第5期);第471-474页 *

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