CN105535481A - Externally vagina applied compound traditional Chinese medicine gel and preparation method thereof - Google Patents
Externally vagina applied compound traditional Chinese medicine gel and preparation method thereof Download PDFInfo
- Publication number
- CN105535481A CN105535481A CN201511012861.2A CN201511012861A CN105535481A CN 105535481 A CN105535481 A CN 105535481A CN 201511012861 A CN201511012861 A CN 201511012861A CN 105535481 A CN105535481 A CN 105535481A
- Authority
- CN
- China
- Prior art keywords
- parts
- mixture
- following material
- radix
- antiseptic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 38
- 210000001215 vagina Anatomy 0.000 title claims abstract description 28
- 150000001875 compounds Chemical class 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title abstract description 15
- 238000001879 gelation Methods 0.000 title description 2
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 30
- 239000003961 penetration enhancing agent Substances 0.000 claims abstract description 18
- 239000002562 thickening agent Substances 0.000 claims abstract description 18
- SEBIKDIMAPSUBY-ARYZWOCPSA-N Crocin Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)C(C)=CC=CC(C)=C\C=C\C=C(/C)\C=C\C=C(C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SEBIKDIMAPSUBY-ARYZWOCPSA-N 0.000 claims abstract description 10
- 239000009627 gardenia yellow Substances 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims description 50
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 36
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 36
- 238000003756 stirring Methods 0.000 claims description 36
- 241000628997 Flos Species 0.000 claims description 35
- 230000002421 anti-septic effect Effects 0.000 claims description 35
- 239000007788 liquid Substances 0.000 claims description 32
- 239000000725 suspension Substances 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 20
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 20
- 238000001704 evaporation Methods 0.000 claims description 18
- 230000008020 evaporation Effects 0.000 claims description 18
- -1 Span series Polymers 0.000 claims description 16
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 16
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 229920001983 poloxamer Polymers 0.000 claims description 12
- 229960000502 poloxamer Drugs 0.000 claims description 12
- 239000001632 sodium acetate Substances 0.000 claims description 12
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 claims description 11
- 239000005844 Thymol Substances 0.000 claims description 10
- 229960000790 thymol Drugs 0.000 claims description 10
- 244000025254 Cannabis sativa Species 0.000 claims description 9
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 8
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 8
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 8
- 229920002125 Sokalan® Polymers 0.000 claims description 8
- 229960001631 carbomer Drugs 0.000 claims description 8
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 8
- 239000000194 fatty acid Substances 0.000 claims description 8
- 229930195729 fatty acid Natural products 0.000 claims description 8
- 150000004676 glycans Chemical class 0.000 claims description 8
- 239000004310 lactic acid Substances 0.000 claims description 8
- 235000014655 lactic acid Nutrition 0.000 claims description 8
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 8
- 229920001282 polysaccharide Polymers 0.000 claims description 8
- 239000005017 polysaccharide Substances 0.000 claims description 8
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 8
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 claims description 8
- 235000017281 sodium acetate Nutrition 0.000 claims description 8
- 239000000661 sodium alginate Substances 0.000 claims description 8
- 235000010413 sodium alginate Nutrition 0.000 claims description 8
- 229940005550 sodium alginate Drugs 0.000 claims description 8
- 238000013019 agitation Methods 0.000 claims description 6
- 239000013078 crystal Substances 0.000 claims description 6
- 238000004090 dissolution Methods 0.000 claims description 6
- 238000007654 immersion Methods 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 238000010792 warming Methods 0.000 claims description 6
- 238000001238 wet grinding Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 4
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 4
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 4
- 239000010692 aromatic oil Substances 0.000 claims description 4
- 229960002152 chlorhexidine acetate Drugs 0.000 claims description 4
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 4
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 4
- OPGYRRGJRBEUFK-UHFFFAOYSA-L disodium;diacetate Chemical compound [Na+].[Na+].CC([O-])=O.CC([O-])=O OPGYRRGJRBEUFK-UHFFFAOYSA-L 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 4
- 229920000136 polysorbate Polymers 0.000 claims description 4
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 4
- 239000004302 potassium sorbate Substances 0.000 claims description 4
- 235000010241 potassium sorbate Nutrition 0.000 claims description 4
- 229940069338 potassium sorbate Drugs 0.000 claims description 4
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims description 4
- 238000009738 saturating Methods 0.000 claims description 4
- 239000004299 sodium benzoate Substances 0.000 claims description 4
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 4
- 235000010234 sodium benzoate Nutrition 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 235000017454 sodium diacetate Nutrition 0.000 claims description 4
- GYICYQJEVCIYJY-UHFFFAOYSA-N thiophen-1-ylidenemethanone Chemical compound O=C=S1C=CC=C1 GYICYQJEVCIYJY-UHFFFAOYSA-N 0.000 claims description 4
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 claims description 4
- 229960001325 triclocarban Drugs 0.000 claims description 4
- 229960003500 triclosan Drugs 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 2
- 208000009608 Papillomavirus Infections Diseases 0.000 abstract description 8
- 206010046914 Vaginal infection Diseases 0.000 abstract description 7
- 206010008342 Cervix carcinoma Diseases 0.000 abstract description 6
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 abstract description 6
- 201000010881 cervical cancer Diseases 0.000 abstract description 6
- 201000008100 Vaginitis Diseases 0.000 abstract description 4
- 206010008323 cervicitis Diseases 0.000 abstract description 4
- 230000001154 acute effect Effects 0.000 abstract description 3
- 201000003988 chronic cervicitis Diseases 0.000 abstract description 3
- 241001278836 Agrimonia pilosa Species 0.000 abstract 1
- 235000000641 Agrimonia pilosa Nutrition 0.000 abstract 1
- 241001313857 Bletilla striata Species 0.000 abstract 1
- 241000561734 Celosia cristata Species 0.000 abstract 1
- 240000005250 Chrysanthemum indicum Species 0.000 abstract 1
- 235000018959 Chrysanthemum indicum Nutrition 0.000 abstract 1
- 241000037740 Coptis chinensis Species 0.000 abstract 1
- 244000167230 Lonicera japonica Species 0.000 abstract 1
- 235000017617 Lonicera japonica Nutrition 0.000 abstract 1
- 240000004980 Rheum officinale Species 0.000 abstract 1
- 235000008081 Rheum officinale Nutrition 0.000 abstract 1
- 240000003152 Rhus chinensis Species 0.000 abstract 1
- 235000014220 Rhus chinensis Nutrition 0.000 abstract 1
- 240000004534 Scutellaria baicalensis Species 0.000 abstract 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract 1
- 241000767839 Semiaquilegia adoxoides Species 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 240000006688 Telosma cordata Species 0.000 abstract 1
- 235000017352 Telosma cordata Nutrition 0.000 abstract 1
- 201000010442 acute cervicitis Diseases 0.000 abstract 1
- 210000001520 comb Anatomy 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 30
- 230000000694 effects Effects 0.000 description 13
- 238000009472 formulation Methods 0.000 description 10
- 208000022361 Human papillomavirus infectious disease Diseases 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 231100000614 poison Toxicity 0.000 description 9
- 239000003440 toxic substance Substances 0.000 description 8
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 7
- 230000002265 prevention Effects 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 206010061977 Genital infection female Diseases 0.000 description 4
- 208000003251 Pruritus Diseases 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 239000009705 sanhuang Substances 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 210000004291 uterus Anatomy 0.000 description 4
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 3
- 206010047799 Vulvovaginitis trichomonal Diseases 0.000 description 3
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 210000003679 cervix uteri Anatomy 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000002423 protozoacide Substances 0.000 description 3
- 239000000286 vaginal jelly Substances 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010012218 Delirium Diseases 0.000 description 2
- 206010017553 Furuncle Diseases 0.000 description 2
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 241000590428 Panacea Species 0.000 description 2
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- 230000002155 anti-virotic effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000003756 cervix mucus Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 210000003026 hypopharynx Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 230000003821 menstrual periods Effects 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 230000036269 ulceration Effects 0.000 description 2
- 206010046901 vaginal discharge Diseases 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 208000037009 Vaginitis bacterial Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 201000007096 Vulvovaginal Candidiasis Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000003984 candidiasis Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000011833 infective vaginitis Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 238000013160 medical therapy Methods 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides externally vagina applied compound traditional Chinese medicine gel. The gel is prepared from the following components in parts by weight: 0.5-30 parts of bletilla striata, 0.5-30 parts of salviae miltiorrhizae, 0.5-30 parts of Chinese gall, 0.5-30 parts of rheum officinale, 0.5-30 parts of scutellaria baicalensis, 0.5-30 parts of cortex phellodendri, 0.5-30 parts of rhizoma atractylodis, 0.5-30 parts of radix sophorae flavescentis, 0.5-30 parts of coptis chinensis, 0.5-30 parts of gardenia yellow, 0.5-30 parts of fructus cnidii, 0.5-10 parts of semiaquilegia adoxoides, 0.5-10 parts of fructus evodiae, 0.2-1 part of fructus zanthoxyli, 0.5-30 parts of dandelion, 0.5-30 parts of Chinese violet, 0.5-30 parts of chrysanthemum indicum, 0.5-30 parts of lonicera japonica, 0.5-30 parts of agrimonia pilosa ledeb, 0.5-30 parts of cockscomb flower, 0.2-2 parts of sulfur powder, 6.3-20 parts of an emulsifier, 0.4-2 parts of a penetration enhancer, 0.3-4 parts of preservative, 2.1-5.5 parts of a thickening agent and 1.5-6 parts of pH regulator. The externally vagina applied compound traditional Chinese medicine gel preparation enables positive cervical HPV infection to become negative, and can be used for stopping development of cervical cancer and treating multiple acute and chronic cervicitis and vaginitis.
Description
Technical field
The present invention relates to and a kind ofly treat vagina Chinese medicine for outer use of multiple gynecological vaginal infection disease and preparation method thereof, particularly relate to a kind of vagina externally used compound Traditional Chinese medicinal gel preparation that cervical HPV infection sun is turned out cloudy and preparation method thereof.
Background technology
Woman uterus vaginal infection is that disease is often sent out by gynecological, and modern medicine many employings antibiotic or synthesis of chemicals are treated, and along with the extensive use of antibiotic and chemicals, its drug resistance and toxicity more and more show.The classical formula toxicity of ancient Chinese medicine is little, and the advantage not easily forming drug resistance is subject to the attention of the world of medicine again.
In recent years, the health and lives of global middle and aged women in the occurred frequently positive serious threat of cervical cancer, and cervical HPV infection is the evil arch-criminal causing cervical cancer, and cervical HPV infection incidence rate finds that there is now more than 20 and plants high-risk hypotype.Over one hundred kind low danger hypotype, only has and effectively removes HPV, could the efficient generation preventing cervical cancer.Modern medicine is vaccinate for the prevention of cervical HPV infection, but current limit four kinds, and expensive, the prevention phase is short, and need repeatedly inject, treatment means is injection of interferon, and its toxic and side effects is large, and the course for the treatment of is long, and cure rate is low, is difficult to promote.The means of Modern medical therapy cervix uteri CIN pathological changes are cervix uteri ring cutting (Leep), this surgical operation, and injury and sequela can hardly be avoided.Medical circle expects a kind of high curative effect, and AT medical science is born.
Summary of the invention
The technical problem to be solved in the present invention is: the defect overcoming existing woman uterus vaginal infection, treatment of human cervical cancer poisonous side effect of medicine is large, the course for the treatment of is long, cure rate is low, be difficult to popularization, there is provided a kind of alternative vagina externally used compound Traditional Chinese medicinal gel preparation to treat multiple cervicovaginitis, invention formulation can make cervical HPV infection sun turn out cloudy simultaneously, thus blocks generation and the progress of cervical cancer.
In order to solve the problems of the technologies described above, the present invention proposes following technical proposal: a kind of vagina externally used compound Traditional Chinese medicine gel, and it is made up of the following component according to weight parts:
Pseudobulbus Bletillae (Rhizoma Bletillae) 0.5-30 part, Radix Salviae Miltiorrhizae 0.5-30 part, Galla Chinensis 0.5-30 part, Radix Et Rhizoma Rhei 0.5-30 part, Radix Scutellariae 0.5-30 part, Cortex Phellodendri 0.5-30 part, Rhizoma Atractylodis 0.5-30 part, Radix Sophorae Flavescentis 0.5-30 part, Rhizoma Coptidis 0.5-30 part, Gardenia Yellow 0.5-30 part, Fructus Cnidii 0.5-30 part, Radix Semiaquilegiae 0.5-10 part, Fructus Evodiae 0.5-10 part, Pericarpium Zanthoxyli 0.2-1 part, Herba Taraxaci 0.5-30 part, Herba Violae grass 0.5-30 part, Flos Chrysanthemi Indici 0.5-30 part, Flos Lonicerae 0.5-30 part, Herba Agrimoniae 0.5-30 part, Flos Celosiae Cristatae 0.5-30 part, Cosan 0.2-2 part, emulsifying agent 6.3-20 part, penetration enhancer 0.4-2 part, antiseptic 0.3-4 part, thickening agent 2.1-5.5 part, PH regulator 1.5-6 part.
The further restriction of technique scheme is, described emulsifying agent is one or more mixture of following material: poloxamer, fatty alcohol-polyoxyethylene ether, Span series, TWEEN Series, fatty acid ester series, polyglyceryl fatty acid ester are serial;
Described penetration enhancer is one or more mixture of following material: Borneolum Syntheticum, Mentholum, azone, thiophene ketone or various short saturating aromatic oil;
Described antiseptic is one or more mixture of following material: thymol, Capmul MCM C8, dehydro sodium acetate, potassium sorbate, sodium benzoate, Nipagin ester, triclosan, triclocarban, chlorhexidine acetate, chlorhexidine gluconate, sodium diacetate;
Described thickening agent is one or more mixture of following material: sodium alginate, carbomer, xanthan gum, various natural polysaccharide and modification of polysaccharides, the various polymer of poloxamer;
Described PH regulator is one or more mixture of following material: sodium hydroxide, potassium hydroxide, acetic acid, sodium carbonate, potassium carbonate, triethanolamine, lactic acid, hydrochloric acid, citric acid.
The further restriction of technique scheme is, the preferred poloxamer of described emulsifying agent;
The preferred Borneolum Syntheticum of described penetration enhancer, Mentholum;
The preferred thymol of described antiseptic, Capmul MCM C8, dehydro sodium acetate;
The preferred sodium alginate of described thickening agent, carbomer;
The preferred sodium hydroxide of described PH regulator, potassium hydroxide, acetic acid.
In order to solve the problems of the technologies described above, the present invention proposes following technical proposal: a kind of manufacture method of vagina externally used compound Traditional Chinese medicine gel, comprises the following steps:
Step one, get Pseudobulbus Bletillae (Rhizoma Bletillae) 0.5-30 part, Radix Salviae Miltiorrhizae 0.5-30 part, Galla Chinensis 0.5-30 part, Radix Et Rhizoma Rhei 0.5-30 part, Radix Scutellariae 0.5-30 part, Cortex Phellodendri 0.5-30 part, Rhizoma Atractylodis 0.5-30 part, Radix Sophorae Flavescentis 0.5-30 part, Rhizoma Coptidis 0.5-30 part, Gardenia Yellow 0.5-30 part, Fructus Cnidii 0.5-30 part, Radix Semiaquilegiae 0.5-10 part, Fructus Evodiae 0.5-10 part, Pericarpium Zanthoxyli 0.2-1 part, and add emulsifying agent 0.3-5 part, said components is crushed to 10-1000 order, add boiled water, the weight of boiled water is about the 5-20 of above-mentioned gross weight doubly, dissolve in PH regulator 0.5-1.5 part, stir immersion 2 hours, again in stirring, 97-100 degree Celsius decoct 0.5-2 hour after, squeezing or centrifugal, all take decocting liquid, decocting liquid with in temperature (55-60 DEG C) vacuum method (-0.1MPa) evaporation be concentrated into and be about 60 parts of weight, discard medicinal residues, obtain concentrated solution,
Step 2, get Herba Taraxaci 0.5-30 part, Herba Violae grass 0.5-30 part, Flos Chrysanthemi Indici 0.5-30 part, Flos Lonicerae 0.5-30 part, Herba Agrimoniae 0.5-30 part, Flos Celosiae Cristatae 0.5-30 part, by said components coarse crushing 3-10 order, add boiled water, boiled water weight is that step 2 newly adds the 5-20 of the gross weight of component doubly, dissolve in PH regulator 0.5-1.5 part, soak 0.5-3 hour, in stirring, slow fire (98-100 DEG C) decocts 20-60 minute again, entirely get decocting liquid with in temperature (55-70 DEG C) vacuum (-0.1MPa) evaporation be concentrated into about 30 parts of weight, discard medicinal residues, obtain concentrated solution,
The concentrated solution that blend step one obtains and the concentrated solution that step 2 obtains, obtain mixed concentrated liquid;
Step 3, gets Cosan 0.2-2 part, penetration enhancer 0.4-2 part, emulsifying agent 2-5 part, above-mentioned three kinds of component wet grindings is become ultra-fine serosity, then admixes in the mixed concentrated liquid that step 2 obtains, obtains suspension;
Step 4, suspension step 3 obtained is warming up to 60-80 degree Celsius; 60-100 DEG C is heated to dissolve antiseptic 0.25-3 part with emulsifying agent 4-10 part, antiseptic course of dissolution needs Keep agitation more than 20 minutes, by the time solution completely as clear as crystal after again antiseptic solution is added the suspension after intensification, after stirring about 30 minutes, then dissolve in antiseptic 0.05-1 part; Obtain suspension;
Step 5, in the suspension that step 4 obtains, adds thickening agent 2.1-5.5 part powder of mix homogeneously, stirs, obtain gelinite;
Step 6, the pH value of the gelinite of determination step five, adds appropriate PH regulator 0.5-3 part and regulates PH to 4.0-4.8, weigh, and rear water feeding method or stirring evaporation regulate gross weight to be 100 parts.
Compared with prior art, the present invention has following beneficial effect:
One, the purposes ancient Chinese medicinal formulae SANHUANG Detoxication Decoction and wuwei xiaodu drink exploitation made new advances and usage." the SANHUANG Detoxication Decoction (Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, Gardenia Yellow " and " wuwei xiaodu drink (Herba Taraxaci, Herba Violae, Flos Lonicerae, Flos Chrysanthemi Indici, Radix Semiaquilegiae) " of Chinese medicine is the classics recipe of heat-clearing and toxic substances removing.Often be used as " heat clearing away by old docter of TCM, pathogenic fire purging, removing toxic substances ", treatment laryngopharynx swelling and pain or " large hot delirium, send out speckle jaundice, tell nosebleed hematochezia " and " heat-clearing and toxic substances removing, dissipation furuncle carbuncle " use, modern medicine thinks that this two prescription all has the antiviral effect of broad-spectrum sterilization antiinflammatory, it is main that usage is drunk oral mainly with soup, occasionally stick with paste external curing sores ulceration of skin as washing liquid or cream, the present inventor thinks cervicovaginal disease, pathogeny mostly still is ' damp-heat vaginal discharge ", wet, heat or fire-toxin are for suffering from, therefore two prescriptions of heat-clearing and toxic substances removing can be worked in coordination with the nucleus used as vagina externally used antimicrobial antivirus gel preparation, coordinate Rhizoma Osmundae, Radix Sanguisorbae, Radix Sophorae Flavescentiss etc. drive damp and hot medicine, be used for the various vagina cervical infection of prevention and therapy, particularly be used as the nucleus of anti-cervical HPV infection formula.Through the clinical verification of inventor's more than two decades, this pharmaceutical formulation was through course for the treatment of of 7-14 days, all effective for multiple acute and chronic cervicovaginal inflammation (comprising trichomonal vaginitis, bacterial vaginitis, candidal vaginitis, chronic cervicitis etc.), effective percentage reaches 99%, and cure rate reaches 90%.Through the course for the treatment of of 3-6 month, cervical HPV negative conversion rate reached 80%, and through following up a case by regular visits to 1-2, HPV negative conversion rate does not change, and shows that its anti-HPV effect is affirmed lastingly.
Two, cold relieving is warmed up the Chinese Traditional Medicine composition Fructus Evodiae in palace, Pericarpium Zanthoxyli, integration be applied to external preparation, reach regulating menstruation by the approach of vagina administration, the special pharmacological effect of warm uterus, promoting blood circulation and stopping pain, killing parasites for relieving itching.
The composition three, Cosan, Herba Agrimoniae, Flos Celosiae Cristatae, thymol etc. with antibacterial protozoacide effect is applied to the effect reaching the various gynecological infection of prevention and therapy in vaginal jellies.Herba Agrimoniae, Flos Celosiae Cristatae are commonly used to treat various gynecological infection " panacea ", but be commonly used for decoct and take orally, and the present inventor is innovatively by its auxiliary element as vagina externally used antimicrobial protozoacide slow releasing agent, and effect is more better than taking orally, and side effect is less.
Detailed description of the invention
The present invention proposes a kind of vagina externally used compound Traditional Chinese medicine gel, and it is made up of the following component according to weight parts:
Pseudobulbus Bletillae (Rhizoma Bletillae) 0.5-30 part, Radix Salviae Miltiorrhizae 0.5-30 part, Galla Chinensis 0.5-30 part, Radix Et Rhizoma Rhei 0.5-30 part, Radix Scutellariae 0.5-30 part, Cortex Phellodendri 0.5-30 part, Rhizoma Atractylodis 0.5-30 part, Radix Sophorae Flavescentis 0.5-30 part, Rhizoma Coptidis 0.5-30 part, Gardenia Yellow 0.5-30 part, Fructus Cnidii 0.5-30 part, Radix Semiaquilegiae 0.5-10 part, Fructus Evodiae 0.5-10 part, Pericarpium Zanthoxyli 0.2-1 part, Herba Taraxaci 0.5-30 part, Herba Violae grass 0.5-30 part, Flos Chrysanthemi Indici 0.5-30 part, Flos Lonicerae 0.5-30 part, Herba Agrimoniae 0.5-30 part, Flos Celosiae Cristatae 0.5-30 part, Cosan 0.2-2 part, emulsifying agent 6.3-20 part, penetration enhancer 0.4-2 part, antiseptic 0.3-4 part, thickening agent 2.1-5.5 part, PH regulator 1.5-6 part.
Described emulsifying agent is one or more mixture of following material: poloxamer, fatty alcohol-polyoxyethylene ether, Span series, TWEEN Series, fatty acid ester series, polyglyceryl fatty acid ester are serial.
The preferred poloxamer of described emulsifying agent.
Described penetration enhancer is one or more mixture of following material: Borneolum Syntheticum, Mentholum, azone, thiophene ketone or various short saturating aromatic oil.
The preferred Borneolum Syntheticum of described penetration enhancer, Mentholum.
Described antiseptic is one or more mixture of following material: thymol, Capmul MCM C8, dehydro sodium acetate, potassium sorbate, sodium benzoate, Nipagin ester, triclosan, triclocarban, chlorhexidine acetate, chlorhexidine gluconate, sodium diacetate.
The preferred thymol of described antiseptic, Capmul MCM C8, dehydro sodium acetate.
Described thickening agent is one or more mixture of following material: sodium alginate, carbomer, xanthan gum, various natural polysaccharide and modification of polysaccharides, the various polymer of poloxamer.
The preferred sodium alginate of described thickening agent, carbomer.
Described PH regulator is one or more mixture of following material: sodium hydroxide, potassium hydroxide, acetic acid, sodium carbonate, potassium carbonate, triethanolamine, lactic acid, hydrochloric acid, citric acid.
The preferred sodium hydroxide of described PH regulator, potassium hydroxide, acetic acid.
The invention allows for the manufacture method of above-mentioned vagina externally used compound Traditional Chinese medicine gel, comprise the following steps:
Step one, get Pseudobulbus Bletillae (Rhizoma Bletillae) 0.5-30 part, Radix Salviae Miltiorrhizae 0.5-30 part, Galla Chinensis 0.5-30 part, Radix Et Rhizoma Rhei 0.5-30 part, Radix Scutellariae 0.5-30 part, Cortex Phellodendri 0.5-30 part, Rhizoma Atractylodis 0.5-30 part, Radix Sophorae Flavescentis 0.5-30 part, Rhizoma Coptidis 0.5-30 part, Gardenia Yellow 0.5-30 part, Fructus Cnidii 0.5-30 part, Radix Semiaquilegiae 0.5-10 part, Fructus Evodiae 0.5-10 part, Pericarpium Zanthoxyli 0.2-1 part, and add emulsifying agent 0.3-5 part, said components is crushed to 10-1000 order, add boiled water, the weight of boiled water is about the 5-20 of above-mentioned gross weight doubly, dissolve in PH regulator sodium hydroxide (or potassium hydroxide) 0.5-1.5 part, stir immersion 2 hours, again in stirring, 97-100 degree Celsius decoct 0.5-2 hour after, squeezing or centrifugal, all take decocting liquid, decocting liquid with in temperature (55-60 DEG C) vacuum method (-0.1MPa) evaporation be concentrated into and be about 60 parts of weight, discard medicinal residues, obtain concentrated solution,
Step 2, get Herba Taraxaci 0.5-30 part, Herba Violae grass 0.5-30 part, Flos Chrysanthemi Indici 0.5-30 part, Flos Lonicerae 0.5-30 part, Herba Agrimoniae 0.5-30 part, Flos Celosiae Cristatae 0.5-30 part, by said components coarse crushing 3-10 order, add boiled water, boiled water weight is that step 2 newly adds the 5-20 of the gross weight of component doubly, dissolve in PH regulator lactic acid 0.5-1.5 part, soak 0.5-3 hour, in stirring, slow fire (98-100 DEG C) decocts 20-60 minute again, entirely get decocting liquid with in temperature (55-70 DEG C) vacuum (-0.1MPa) evaporation be concentrated into about 30 parts of weight, discard medicinal residues, obtain concentrated solution,
The concentrated solution that blend step one obtains and the concentrated solution that step 2 obtains, obtain mixed concentrated liquid;
Step 3, gets Cosan 0.2-2 part, penetration enhancer 0.4-2 part, emulsifying agent 2-5 part, above-mentioned three kinds of component wet grindings is become the following serosity of particle diameter 1um, then admixes in the mixed concentrated liquid that step 2 obtains, obtains suspension;
Step 4, suspension step 3 obtained is warming up to 60-80 degree Celsius; 60-100 DEG C is heated to dissolve antiseptic 0.25-3 part with emulsifying agent 4-10 part, antiseptic course of dissolution needs Keep agitation more than 20 minutes, by the time solution completely as clear as crystal after again antiseptic solution is added the suspension after intensification, after stirring about 30 minutes, then dissolve in antiseptic 0.05-1 part; Obtain suspension;
Step 5, in the suspension that step 4 obtains, adds thickening agent 2.1-5.5 part powder of mix homogeneously, stirs, obtain gelinite;
Step 6, the pH value of the gelinite of determination step five, adds appropriate PH regulator 0.5-3 part and regulates PH to 4.0-4.8, weigh, and rear water feeding method or stirring evaporation regulate gross weight to be 100 parts.
The using method of above-mentioned vagina externally used compound Traditional Chinese medicine gel is as follows: above-mentioned vagina externally used compound Traditional Chinese medicine gel is dispensed into the self-supporting pencil of vaginal jellies, often prop up 3 grams, every night before sleep, cervicovaginal position self administration of medication one, except menstrual period.
Preparation embodiment 1
Step one, get the Pseudobulbus Bletillae (Rhizoma Bletillae) 0.5 part, Radix Salviae Miltiorrhizae 15 parts, Galla Chinensis 30 parts, Radix Et Rhizoma Rhei 15 parts, Radix Scutellariae 0.5 part, Cortex Phellodendri 15 parts, Rhizoma Atractylodis 30 parts, Radix Sophorae Flavescentis 0.5 part, Rhizoma Coptidis 15 parts, Gardenia Yellow 30 parts, Fructus Cnidii 15 parts, Radix Semiaquilegiae 0.5 part, Fructus Evodiae 10 parts, Pericarpium Zanthoxyli 1 part, and add emulsifying agent 0.3 part, said components is crushed to 10-1000 order, add boiled water, the weight of boiled water is 2000 parts, dissolve in PH regulator sodium hydroxide (or potassium hydroxide) 0.5 part, stir immersion 2 hours, again in stirring, 97-100 degree Celsius decoct 0.5-2 hour after, squeezing or centrifugal, all take decocting liquid, decocting liquid with in temperature (55-60 DEG C) vacuum method (-0.1MPa) evaporation be concentrated into and be about 60 parts of weight, discard medicinal residues, obtain concentrated solution,
Step 2, get Herba Taraxaci 15 parts, Herba Violae grass 30 parts, Flos Chrysanthemi Indici 0.5 part, Flos Lonicerae 15 parts, Herba Agrimoniae 15 parts, Flos Celosiae Cristatae 0.5 part, by said components coarse crushing 3-10 order, add boiled water, boiled water weight is 750 parts, dissolve in PH regulator lactic acid 0.5 part, soak 0.5-3 hour, then slow fire (98-100 DEG C) decocts 20-60 minute in stirring, entirely get decocting liquid with in warm (55-70 DEG C) vacuum (-0.1MPa) evaporation be concentrated into about 30 parts of weight, discard medicinal residues, obtain concentrated solution;
The concentrated solution that blend step one obtains and the concentrated solution that step 2 obtains, obtain mixed concentrated liquid;
Step 3, gets Cosan 1 part, penetration enhancer 0.4 part, emulsifying agent 5 parts, above-mentioned three kinds of component wet grindings is become ultra-fine serosity, then admixes in the mixed concentrated liquid that step 2 obtains, obtains suspension;
Step 4, suspension step 3 obtained is warming up to 60-80 degree Celsius; 60-100 DEG C is heated to dissolve antiseptic 0.25 part with emulsifying agent 4 parts, antiseptic course of dissolution needs Keep agitation more than 20 minutes, by the time solution completely as clear as crystal after again antiseptic solution is added the suspension after intensification, after stirring about 30 minutes, then dissolve in antiseptic 1 part; Obtain suspension;
Step 5, in the suspension that step 4 obtains, adds thickening agent 2.1 parts of powder of mix homogeneously, stirs, obtain gelinite;
Step 6, the pH value of the gelinite of determination step five, adds appropriate PH regulator 0.5-3 part and regulates PH to 4.0-4.8, weigh, and rear water feeding method or stirring evaporation regulate gross weight to be 100 parts.
Preparation embodiment 2
Step one, get the Pseudobulbus Bletillae (Rhizoma Bletillae) 30 parts, Radix Salviae Miltiorrhizae 0.5 part, Galla Chinensis 15 parts, Radix Et Rhizoma Rhei 0.5 part, Radix Scutellariae 15 parts, Cortex Phellodendri 0.5 part, Rhizoma Atractylodis 15 parts, Radix Sophorae Flavescentis 15 parts, Rhizoma Coptidis 0.5 part, Gardenia Yellow 0.5 part, Fructus Cnidii 30 parts, Radix Semiaquilegiae 15 parts, Fructus Evodiae 0.5 part, Pericarpium Zanthoxyli 0.5 part, and add emulsifying agent 3 parts, said components is crushed to 10-1000 order, add boiled water, the weight of boiled water is 150 parts, dissolve in PH regulator sodium hydroxide (or potassium hydroxide) 1 part, stir immersion 2 hours, again in stirring, 97-100 degree Celsius decoct 0.5-2 hour after, squeezing or centrifugal, all take decocting liquid, decocting liquid with in temperature (55-60 DEG C) vacuum method (-0.1MPa) evaporation be concentrated into and be about 60 parts of weight, discard medicinal residues, obtain concentrated solution,
Step 2, get Herba Taraxaci 0.5 part, Herba Violae grass 15 parts, Flos Chrysanthemi Indici 30 parts, Flos Lonicerae 0.5 part, Herba Agrimoniae 30 parts, Flos Celosiae Cristatae 15 parts, by said components coarse crushing 3-10 order, add boiled water, boiled water weight is 800 parts, dissolve in PH regulator lactic acid 1 part, soak 0.5-3 hour, then slow fire (98-100 DEG C) decocts 20-60 minute in stirring, entirely get decocting liquid with in warm (55-70 DEG C) vacuum (-0.1MPa) evaporation be concentrated into about 30 parts of weight, discard medicinal residues, obtain concentrated solution;
The concentrated solution that blend step one obtains and the concentrated solution that step 2 obtains, obtain mixed concentrated liquid;
Step 3, gets Cosan 0.2 part, penetration enhancer 1 part, emulsifying agent 2 parts, above-mentioned three kinds of component wet grindings is become ultra-fine serosity, then admixes in the mixed concentrated liquid that step 2 obtains, obtains suspension;
Step 4, suspension step 3 obtained is warming up to 60-80 degree Celsius; 60-100 DEG C is heated to dissolve antiseptic 1.5 parts with emulsifying agent 7 parts, antiseptic course of dissolution needs Keep agitation more than 20 minutes, by the time solution completely as clear as crystal after again antiseptic solution is added the suspension after intensification, after stirring about 30 minutes, then dissolve in antiseptic 0.05 part; Obtain suspension;
Step 5, in the suspension that step 4 obtains, adds thickening agent 5.5 parts of powder of mix homogeneously, stirs, obtain gelinite;
Step 6, the pH value of the gelinite of determination step five, adds appropriate PH regulator 0.5-3 part and regulates PH to 4.0-4.8, weigh, and rear water feeding method or stirring evaporation regulate gross weight to be 100 parts.
Preparation embodiment 3
Step one, get the Pseudobulbus Bletillae (Rhizoma Bletillae) 15 parts, Radix Salviae Miltiorrhizae 30 parts, Galla Chinensis 0.5 part, Radix Et Rhizoma Rhei 30 parts, Radix Scutellariae 30 parts, Cortex Phellodendri 30 parts, Rhizoma Atractylodis 0.5 part, Radix Sophorae Flavescentis 30 parts, Rhizoma Coptidis 30 parts, Gardenia Yellow 15 parts, Fructus Cnidii 0.5 part, Radix Semiaquilegiae 10 parts, Fructus Evodiae 5 parts, Pericarpium Zanthoxyli 0.2 part, and add emulsifying agent 5 parts, said components is crushed to 10-1000 order, add boiled water, the weight of boiled water is 2500 parts, dissolve in PH regulator sodium hydroxide (or potassium hydroxide) 1.5 parts, stir immersion 2 hours, again in stirring, 97-100 degree Celsius decoct 0.5-2 hour after, squeezing or centrifugal, all take decocting liquid, decocting liquid with in temperature (55-60 DEG C) vacuum method (-0.1MPa) evaporation be concentrated into and be about 60 parts of weight, discard medicinal residues, obtain concentrated solution,
Step 2, get Herba Taraxaci 30 parts, Herba Violae grass 0.5 part, Flos Chrysanthemi Indici 15 parts, Flos Lonicerae 30 parts, Herba Agrimoniae 0.5 part, Flos Celosiae Cristatae 30 parts, by said components coarse crushing 3-10 order, add boiled water, boiled water weight is 1000 parts, dissolve in PH regulator lactic acid 1.5 parts, soak 0.5-3 hour, in stirring, slow fire (98-100 DEG C) decocts 20-60 minute again, entirely get decocting liquid with in temperature (55-70 DEG C) vacuum (-0.1MPa) evaporation be concentrated into about 30 parts of weight, discard medicinal residues, obtain concentrated solution;
The concentrated solution that blend step one obtains and the concentrated solution that step 2 obtains, obtain mixed concentrated liquid;
Step 3, gets Cosan 2 parts, penetration enhancer 2 parts, emulsifying agent 3 parts, above-mentioned three kinds of component wet grindings is become ultra-fine serosity, then admixes in the mixed concentrated liquid that step 2 obtains, obtains suspension;
Step 4, suspension step 3 obtained is warming up to 60-80 degree Celsius; 60-100 DEG C is heated to dissolve antiseptic 3 parts with emulsifying agent 10 parts, antiseptic course of dissolution needs Keep agitation more than 20 minutes, by the time solution completely as clear as crystal after again antiseptic solution is added the suspension after intensification, after stirring about 30 minutes, then dissolve in antiseptic 0.5 part; Obtain suspension;
Step 5, in the suspension that step 4 obtains, adds thickening agent 4 parts of powder of mix homogeneously, stirs, obtain gelinite;
Step 6, the pH value of the gelinite of determination step five, adds appropriate PH regulator 0.5-3 part and regulates PH to 4.0-4.8, weigh, and rear water feeding method or stirring evaporation regulate gross weight to be 100 parts.
Enumerate the case of several application vagina externally used compound of the present invention Traditional Chinese medicine gel treatment below
Case one
Defend * orchid, 28 years old, people from Changsha, in May, 2007, suffer from trichomonal vaginitis, external invention formulation 7 days and healing.Continue medication 7 days.Follow up a case by regular visits to 1 year after drug withdrawal, do not recur again.
Case two
Poplar * show, 37 years old, Guangzhou Huadu people, in JIUYUE, 2008, suffered from bacterial vaginosis, and external invention formulation five days and odorless are without secretions, and continue medication 10 days, thorough rehabilitation, follows up a case by regular visits to 1 year, does not recur again.
Case three
Li Mei *, 40 years old, people from Wenzhou, in April, 2010, because of drug resistance candidal vaginitis repeatedly pruritus outbreak control, eliminate pruritis completely through invention formulation external 10 days, continue use after 20 days, bacterium inspection candidiasis is negative, and drug withdrawal, follows up a case by regular visits to and do not recur for 3 years.
Case four
Deng * Jie, 55 years old, people from Suzhou, in July, 2009, because of bacillary after menolipsis, monilial vaginitis recurrent exerbation was controlled, and through invention formulation external drug withdrawal after month, follows up a case by regular visits to 5 years, infective vaginitis does not occur.
Case five
Younger sister * Liao, 41 years old, people of Guangzhou, because pruritus of vagina was to various big hospital diagnosis and treatment 1 year, did not draw definite cause of disease conclusion in 2006, and symptom still, the spring in 2007, with invention formulation external after 20 days, eliminate completely by symptom, continues medication drug withdrawal in February, follow up a case by regular visits to and do not recur for 5 years.
Case six
Journey * beautiful jade, 40 years old, Shenzhen people, in March, 2010 because of menstrual period long, dark through color, lower abdomen has a dull ache to examine, and advise it with invention formulation with after 20 days, pass through all are normal later.
Case seven
The beautiful * of hair, 51 years old, people from Shenzhen, in JIUYUE, 2008, did not heal because pelvic inflammatory disease is prolonged, and suffering from takes medicine has an injection to control, external invention formulation 2 months, confirms pelvic inflammatory disease rehabilitation through diagnostic imaging, continues medication drug withdrawal in 3 months, follows up a case by regular visits to and do not recur for 5 years.
Case eight
Its * of Rhizoma Zingiberis Recens, 55 years old, people from Guangzhou, health check-up in 2009 found that cervical HPV 16 is positive, checks still positive, start external invention formulation in May, 2010 and turn out cloudy for 6 months, steadiness medication drug withdrawal after 3 months, follow up a case by regular visits to and do not recur for 3 years after 1 year.
Case nine
Yellow * is glad, 41 years old, Shenzhen people, in October, 2008 health check-up find cervix uteri hpv18,51,56 positive, through invention formulation external 6 months, three kinds of viruses all turned negative, and continued medication drug withdrawal after 3 months, followed up a case by regular visits to 5 years, and HPV all continues negative.
The present invention has following beneficial effect:
One, the purposes ancient Chinese medicinal formulae SANHUANG Detoxication Decoction and wuwei xiaodu drink exploitation made new advances and usage." the SANHUANG Detoxication Decoction (Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Radix Et Rhizoma Rhei, Gardenia Yellow " and " wuwei xiaodu drink (Herba Taraxaci, Herba Violae, Flos Lonicerae, Flos Chrysanthemi Indici, Radix Semiaquilegiae) " of Chinese medicine is the classics recipe of heat-clearing and toxic substances removing.Often be used as " heat clearing away by old docter of TCM, pathogenic fire purging, removing toxic substances " treat laryngopharynx swelling and pain or " large hot delirium, send out speckle jaundice, tell nosebleed hematochezia " and " heat-clearing and toxic substances removing, dissipation furuncle carbuncle " use, modern medicine thinks that this two prescription all has the antiviral effect of broad-spectrum sterilization antiinflammatory, it is main that usage is drunk oral mainly with soup, occasionally stick with paste external curing sores ulceration of skin as washing liquid or cream, the present inventor thinks cervicovaginal disease, pathogeny mostly still is ' damp-heat vaginal discharge ", wet, heat is for suffering from, therefore two prescriptions of heat-clearing and toxic substances removing can be worked in coordination with the nucleus used as vagina externally used antimicrobial antivirus gel preparation, be used for the various vagina cervical infection of prevention and therapy, particularly be used as the nucleus of anti-cervical HPV infection formula.Through the clinical verification of inventor's more than two decades, this preparation was through course for the treatment of of 7-14 days, all effective for multiple acute and chronic cervicovaginal inflammation (comprising trichomonal vaginitis, bacterial vaginitis, candidal vaginitis, chronic cervicitis etc.), effective percentage reaches 99%, and cure rate reaches 90%.Through the course for the treatment of of 3-6 month, cervical HPV negative conversion rate reached 80%, and through following up a case by regular visits to 1-2, HPV negative conversion rate changes, and shows that its anti-HPV effect is affirmed lastingly.
The integration such as Chinese Traditional Medicine composition Fructus Evodiae, Pericarpium Zanthoxyli of two, cold relieving being warmed up palace is applied to external preparation, reaches regulating menstruation, the special pharmacological effect of warm uterus, promoting blood circulation and stopping pain by the approach of vagina administration.
The composition three, Cosan, Herba Agrimoniae, Flos Celosiae Cristatae, thymol etc. with antibacterial protozoacide effect is applied to the effect reaching the various gynecological infection of prevention and therapy in vaginal jellies.Herba Agrimoniae, Flos Celosiae Cristatae are commonly used to treat various gynecological infection " panacea ", but be commonly used for decoct and take orally, and the present inventor is innovatively by its auxiliary element as antibiotic external used slow releasing agent, and effect is more better than taking orally, and side effect is less.
Claims (6)
1. a vagina externally used compound Traditional Chinese medicine gel, is characterized in that, it is made up of the following component according to weight parts:
Pseudobulbus Bletillae (Rhizoma Bletillae) 0.5-30 part, Radix Salviae Miltiorrhizae 0.5-30 part, Galla Chinensis 0.5-30 part, Radix Et Rhizoma Rhei 0.5-30 part, Radix Scutellariae 0.5-30 part, Cortex Phellodendri 0.5-30 part, Rhizoma Atractylodis 0.5-30 part, Radix Sophorae Flavescentis 0.5-30 part, Rhizoma Coptidis 0.5-30 part, Gardenia Yellow 0.5-30 part, Fructus Cnidii 0.5-30 part, Radix Semiaquilegiae 0.5-10 part, Fructus Evodiae 0.5-10 part, Pericarpium Zanthoxyli 0.2-1 part, Herba Taraxaci 0.5-30 part, Herba Violae grass 0.5-30 part, Flos Chrysanthemi Indici 0.5-30 part, Flos Lonicerae 0.5-30 part, Herba Agrimoniae 0.5-30 part, Flos Celosiae Cristatae 0.5-30 part, Cosan 0.2-2 part, emulsifying agent 6.3-20 part, penetration enhancer 0.4-2 part, antiseptic 0.3-4 part, thickening agent 2.1-5.5 part, PH regulator 1.5-6 part.
2. a kind of vagina externally used compound Traditional Chinese medicine gel according to claim 1, it is characterized in that, described emulsifying agent is one or more mixture of following material: poloxamer, fatty alcohol-polyoxyethylene ether, Span series, TWEEN Series, fatty acid ester series, polyglyceryl fatty acid ester are serial;
Described penetration enhancer is one or more mixture of following material: Borneolum Syntheticum, Mentholum, azone, thiophene ketone or various short saturating aromatic oil;
Described antiseptic is one or more mixture of following material: thymol, Capmul MCM C8, dehydro sodium acetate, potassium sorbate, sodium benzoate, Nipagin ester, triclosan, triclocarban, chlorhexidine acetate, chlorhexidine gluconate, sodium diacetate;
Described thickening agent is one or more mixture of following material: sodium alginate, carbomer, xanthan gum, various natural polysaccharide and modification of polysaccharides, poloxamer, various polymer;
Described PH regulator is one or more mixture of following material: sodium hydroxide, potassium hydroxide, acetic acid, sodium carbonate, potassium carbonate, triethanolamine, lactic acid, hydrochloric acid, citric acid.
3. a kind of vagina externally used compound Traditional Chinese medicine gel according to claim 2, is characterized in that, the preferred poloxamer of described emulsifying agent;
The preferred Borneolum Syntheticum of described penetration enhancer, Mentholum;
The preferred thymol of described antiseptic, Capmul MCM C8, dehydro sodium acetate;
The preferred sodium alginate of described thickening agent, carbomer;
The preferred sodium hydroxide of described PH regulator, potassium hydroxide, acetic acid.
4. prepare a manufacture method for vagina externally used compound Traditional Chinese medicine gel as claimed in claim 1, it is characterized in that, comprise the following steps:
Step one, get Pseudobulbus Bletillae (Rhizoma Bletillae) 0.5-30 part, Radix Salviae Miltiorrhizae 0.5-30 part, Galla Chinensis 0.5-30 part, Radix Et Rhizoma Rhei 0.5-30 part, Radix Scutellariae 0.5-30 part, Cortex Phellodendri 0.5-30 part, Rhizoma Atractylodis 0.5-30 part, Radix Sophorae Flavescentis 0.5-30 part, Rhizoma Coptidis 0.5-30 part, Gardenia Yellow 0.5-30 part, Fructus Cnidii 0.5-30 part, Radix Semiaquilegiae 0.5-10 part, Fructus Evodiae 0.5-10 part, Pericarpium Zanthoxyli 0.2-1 part, and add emulsifying agent 0.3-5 part, said components is crushed to 10-1000 order, add boiled water, the weight of boiled water is about the 5-20 of above-mentioned gross weight doubly, dissolve in PH regulator 0.5-1.5 part, stir immersion 2 hours, again in stirring, 97-100 degree Celsius decoct 0.5-2 hour after, squeezing or centrifugal, all take decocting liquid, decocting liquid with in temperature (55-60 DEG C) vacuum method (-0.1MPa) evaporation be concentrated into and be about 60 parts of weight, discard medicinal residues, obtain concentrated solution,
Step 2, get Herba Taraxaci 0.5-30 part, Herba Violae grass 0.5-30 part, Flos Chrysanthemi Indici 0.5-30 part, Flos Lonicerae 0.5-30 part, Herba Agrimoniae 0.5-30 part, Flos Celosiae Cristatae 0.5-30 part, by said components coarse crushing 3-10 order, add boiled water, boiled water weight is that step 2 newly adds the 5-20 of the gross weight of component doubly, dissolve in PH regulator 0.5-1.5 part, soak 0.5-3 hour, in stirring, slow fire (98-100 DEG C) decocts 20-60 minute again, entirely get decocting liquid with in temperature (55-70 DEG C) vacuum (-0.1MPa) evaporation be concentrated into about 30 parts of weight, discard medicinal residues, obtain concentrated solution,
The concentrated solution that blend step one obtains and the concentrated solution that step 2 obtains, obtain mixed concentrated liquid;
Step 3, gets Cosan 0.2-2 part, penetration enhancer 0.4-2 part, emulsifying agent 2-5 part, becomes particle diameter to be less than 1um serosity above-mentioned three kinds of component wet grindings, then admixes in the mixed concentrated liquid that step 2 obtains, obtains suspension;
Step 4, suspension step 3 obtained is warming up to 60-80 degree Celsius; 60-100 DEG C is heated to dissolve antiseptic 0.25-3 part with emulsifying agent 4-10 part, antiseptic course of dissolution needs Keep agitation more than 20 minutes, by the time solution completely as clear as crystal after again antiseptic solution is added the suspension after intensification, after stirring about 30 minutes, then dissolve in antiseptic 0.05-1 part; Obtain suspension;
Step 5, in the suspension that step 4 obtains, adds thickening agent 2.1-5.5 part powder of mix homogeneously, stirs, obtain gelinite;
Step 6, the pH value of the gelinite of determination step five, adds appropriate PH regulator 0.5-3 part and regulates PH to 4.0-4.8, weigh, and rear water feeding method or stirring evaporation regulate gross weight to be 100 parts.
5. the manufacture method of vagina externally used compound Traditional Chinese medicine gel according to claim 4, it is characterized in that, described emulsifying agent is one or more mixture of following material: poloxamer, fatty alcohol-polyoxyethylene ether, Span series, TWEEN Series, fatty acid ester series, polyglyceryl fatty acid ester are serial;
Described penetration enhancer is one or more mixture of following material: Borneolum Syntheticum, Mentholum, azone, thiophene ketone or various short saturating aromatic oil;
Described antiseptic is one or more mixture of following material: thymol, Capmul MCM C8, dehydro sodium acetate, potassium sorbate, sodium benzoate, Nipagin ester, triclosan, triclocarban, chlorhexidine acetate, chlorhexidine gluconate, sodium diacetate;
Described thickening agent is one or more mixture of following material: sodium alginate, carbomer, xanthan gum, various natural polysaccharide and modification of polysaccharides, the various polymer of poloxamer;
Described PH regulator is one or more mixture of following material: sodium hydroxide, potassium hydroxide, acetic acid, sodium carbonate, potassium carbonate, triethanolamine, lactic acid, hydrochloric acid, citric acid.
6. the manufacture method of vagina externally used compound Traditional Chinese medicine gel according to claim 5, is characterized in that,
Described emulsifying agent is poloxamer;
Described penetration enhancer is one or more mixture of following material: Borneolum Syntheticum, Mentholum;
Described antiseptic is one or more mixture of following material: thymol, Capmul MCM C8, dehydro sodium acetate;
Described thickening agent is one or more mixture of following material: sodium alginate, carbomer;
Described PH regulator is one or more mixture of following material: sodium hydroxide, potassium hydroxide, acetic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511012861.2A CN105535481A (en) | 2015-12-31 | 2015-12-31 | Externally vagina applied compound traditional Chinese medicine gel and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511012861.2A CN105535481A (en) | 2015-12-31 | 2015-12-31 | Externally vagina applied compound traditional Chinese medicine gel and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105535481A true CN105535481A (en) | 2016-05-04 |
Family
ID=55815388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201511012861.2A Pending CN105535481A (en) | 2015-12-31 | 2015-12-31 | Externally vagina applied compound traditional Chinese medicine gel and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105535481A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853287A (en) * | 2018-08-07 | 2018-11-23 | 吉林省正肽生物科技有限公司 | Pharmaceutical composition, gel preparation and the application of a kind of anti-human papilloma virus (anti-HPV) and anti-gynaecological imflammation |
| CN109200235A (en) * | 2018-11-29 | 2019-01-15 | 张建青 | A kind of Chinese materia medica preparation and preparation method thereof for eliminating HPV infection |
| CN112138077A (en) * | 2020-10-19 | 2020-12-29 | 青岛浩大生物科技工程有限责任公司 | Marine polysaccharide private antibacterial gel and preparation method thereof |
| CN112220900A (en) * | 2020-09-27 | 2021-01-15 | 大连双迪科技股份有限公司 | Antibacterial lotion and preparation method thereof |
| CN113181336A (en) * | 2021-06-11 | 2021-07-30 | 陕西秦岭七药协同创新中心有限公司 | Traditional Chinese medicine composition and preparation for treating gynecological diseases and preparation method and application thereof |
| CN113730469A (en) * | 2021-07-12 | 2021-12-03 | 江苏实干家生物科技有限公司 | Pure traditional Chinese medicine gel for treating HPV infected cervical cancer and preparation method thereof |
| US11278583B2 (en) * | 2018-03-29 | 2022-03-22 | Zhuanshe DU | Traditional Chinese medicine composition for treating diseases caused by human papillomavirus, preparation method and use thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336991A (en) * | 2008-07-28 | 2009-01-07 | 内蒙古医学院 | Medicine for treating gynaecologic pruritus vulvae and colpitis |
| CN102068640A (en) * | 2011-01-18 | 2011-05-25 | 山西康洁司乐药业有限公司 | Externally-applied traditional Chinese medicine and preparation method thereof |
-
2015
- 2015-12-31 CN CN201511012861.2A patent/CN105535481A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101336991A (en) * | 2008-07-28 | 2009-01-07 | 内蒙古医学院 | Medicine for treating gynaecologic pruritus vulvae and colpitis |
| CN102068640A (en) * | 2011-01-18 | 2011-05-25 | 山西康洁司乐药业有限公司 | Externally-applied traditional Chinese medicine and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 邵丽黎，等: "《女病诊疗全书》", 30 November 2000, 中国医药科技出版社 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11278583B2 (en) * | 2018-03-29 | 2022-03-22 | Zhuanshe DU | Traditional Chinese medicine composition for treating diseases caused by human papillomavirus, preparation method and use thereof |
| CN108853287A (en) * | 2018-08-07 | 2018-11-23 | 吉林省正肽生物科技有限公司 | Pharmaceutical composition, gel preparation and the application of a kind of anti-human papilloma virus (anti-HPV) and anti-gynaecological imflammation |
| CN108853287B (en) * | 2018-08-07 | 2021-06-15 | 吉林省正肽生物科技有限公司 | Pharmaceutical composition for resisting human papilloma virus and gynecological inflammation, gel preparation and application |
| CN109200235A (en) * | 2018-11-29 | 2019-01-15 | 张建青 | A kind of Chinese materia medica preparation and preparation method thereof for eliminating HPV infection |
| CN112220900A (en) * | 2020-09-27 | 2021-01-15 | 大连双迪科技股份有限公司 | Antibacterial lotion and preparation method thereof |
| CN112138077A (en) * | 2020-10-19 | 2020-12-29 | 青岛浩大生物科技工程有限责任公司 | Marine polysaccharide private antibacterial gel and preparation method thereof |
| CN113181336A (en) * | 2021-06-11 | 2021-07-30 | 陕西秦岭七药协同创新中心有限公司 | Traditional Chinese medicine composition and preparation for treating gynecological diseases and preparation method and application thereof |
| CN113730469A (en) * | 2021-07-12 | 2021-12-03 | 江苏实干家生物科技有限公司 | Pure traditional Chinese medicine gel for treating HPV infected cervical cancer and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105535481A (en) | Externally vagina applied compound traditional Chinese medicine gel and preparation method thereof | |
| CN1061854C (en) | Medicinal preparation for treatment and prevention of gynopathy | |
| CN103071128B (en) | Externally-applied plaster for curing dysmenorrhea | |
| CN105998972A (en) | Bacteriostatic gel | |
| CN101214315B (en) | Medicament for preventing and treating gynaecologic hemorrhage and preparation thereof | |
| CN101391015A (en) | External traditional Chinese medicine powder for treating recurrent hemorrhoid | |
| CN105617151A (en) | Powder boiling type traditional Chinese medicine antibacterial and anti-inflammatory agent, preparation method and applications thereof | |
| CN102885873A (en) | Traditional Chinese medicine for treating mammitis and method for preparing traditional Chinese medicine | |
| CN101129872A (en) | Phellodendron bark-coix seed erysipelas powder | |
| CN103751544A (en) | Topically applied paste for treating bedsore | |
| CN103495085B (en) | Traditional Chinese medicine preparation for treating radiodermatitis | |
| CN103330873B (en) | Snake wound rehabilitation medicament | |
| CN103908600A (en) | Externally-applied medicine for treating rheumatoid arthritis damp-heat blockage symptom as well as preparation method and administration method thereof | |
| CN103330872A (en) | Method for preparing snake wound rehabilitation medicament | |
| CN103239677B (en) | Anorectal medicine used for treating ascites and preparation method of anorectal medicine preparation | |
| CN103479859B (en) | Traditional Chinese medicine composition for treating hyperandrogenism of polycystic ovary syndrome | |
| CN104971332A (en) | Traditional Chinese medicine for treating hemorrhoids | |
| CN107823551B (en) | External traditional Chinese medicine preparation for treating anorectal diseases | |
| CN103656486A (en) | Drug for treating psoriasis | |
| CN102228661B (en) | Chinese medicinal cholecystitis treatment mixture for treating chronic cholecystitis | |
| CN102872290B (en) | Chinese medicament for treating menstrual disorder | |
| CN101554432B (en) | Fumigating and washing medicine for curing hemorrhoids | |
| CN105288436A (en) | Medicament for treatment of chronic eczema | |
| CN103566226B (en) | Traditional Chinese medicament for treating suppurative pneumonia | |
| CN104258303A (en) | Traditional Chinese medicine for treating dysmenorrhea |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20181114 Address after: 436000 No. 14-6, No. 14, Huading Industrial Park, East of Pioneering Avenue, Gedian Development Zone, Ezhou City, Hubei Province Applicant after: Hubei Green Unbounded Biotechnology Co., Ltd. Address before: 637300 No. 99 Xinhua Road, Dingshui Town, Nanchong City, Sichuan Province Applicant before: Pu Jingbei |
|
| TA01 | Transfer of patent application right | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160504 |
|
| RJ01 | Rejection of invention patent application after publication |