CN105519548A - Azoxystrobin and tricyclazole compounded suspension and preparation method thereof - Google Patents
Azoxystrobin and tricyclazole compounded suspension and preparation method thereof Download PDFInfo
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- CN105519548A CN105519548A CN201510997696.4A CN201510997696A CN105519548A CN 105519548 A CN105519548 A CN 105519548A CN 201510997696 A CN201510997696 A CN 201510997696A CN 105519548 A CN105519548 A CN 105519548A
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- tricyclazole
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- fluoxastrobin
- azoxystrobin
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
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- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to an azoxystrobin and tricyclazole compounded suspension and a preparation method thereof, and relates to the technical field of rice blast control. The suspension is prepared from 10 parts of azoxystrobin, 30 parts of tricyclazole, 3 parts of fatty alcohol polyoxyethylene ether, 5 parts of styrylphenol polyoxyethylene ether, 0.5 parts of xanthan gum, 0.3 parts of sodium benzoate, 0.5 parts of an antifoaming agent and 50.7 parts of deionized water. The preparation method comprises the following steps: pumping raw materials to a preparation kettle, mixing and stirring the raw materials, carrying out primary grinding through a colloid mill, carrying out fine grinding through a sand mill, sampling and analyzing the above obtained ground mixture, filtering after qualification, metering, packaging, and warehousing. The azoxystrobin and tricyclazole compounded suspension obtained by mixing according to a ratio of 1:3 and having a concentration of 40% has obvious synergistic effects, and preparations with other ratios cannot realize obvious synergistic effects.
Description
Technical field
The present invention relates to rice blast Prevention Technique field, specifically relate to a kind of Fluoxastrobin and the composite suspending agent of tricyclazole and preparation method thereof.
Background technology
At present, the existing bactericidal composition for rice blast control, such as Chinese patent " CN104957167A " discloses one " Diacloden and azoxystrobin pesticide composition ", and wherein effective active composition is Diacloden and Fluoxastrobin, and both proportionings are 1 ~ 85%:1 ~ 85%.Separately have Chinese patent " CN104430364A " to disclose one " composition containing fludioxonil and Fluoxastrobin ", wherein effective active composition is fludioxonil and Fluoxastrobin, and both proportionings are 10:1 ~ 1:10.
Inventor verifies through long term test, and this above-mentioned several bactericidal composition mainly exists following defect:
1), by several concrete proportioning disclosed in above-mentioned several bactericidal composition test, find cannot play good control efficiency to rice blast.
2), for several formulations disclosed in above-mentioned several bactericidal composition, find through verification experimental verification the defect that all there is different problem.Such as, the suspending agent made easily causes product to bond, not easily dispersion suspension in water, or blocking shower nozzle, the phenomenon such as reason precipitation in sprayer, cause spray irregular, easily make crop local produce poisoning, its main cause is that the selection of auxiliary agent and filler all exists different defects.
3), composite problem, by several concrete proportioning disclosed in above-mentioned several bactericidal composition carry out virulence test, heat storage stability test and co-toxicity coefficient measure find, all cannot reach obvious synergistic effect.
Summary of the invention
An object of the present invention is to provide a kind of Fluoxastrobin and the composite suspending agent of tricyclazole, and this suspending agent is reasonable in design, good to the control efficiency of rice blast, and can realize the notable synergistic effect of Fluoxastrobin and tricyclazole.
For achieving the above object, present invention employs following technical scheme:
A kind of Fluoxastrobin and the composite suspending agent of tricyclazole, be made up of the component of following weight portion:
Fluoxastrobin is methoxy acrylic bactericide, efficiently, wide spectrum, all have good activity to nearly all mycota (Ascomycotina, Basidiomycotina, Mastigomycotina and Deuteromycotina) disease such as powdery mildew, banded sclerotial blight, rust, glume blight, net blotch, downy mildew, rice blast etc.Can be used for cauline leaf spraying, seed treatment, also can carry out soil treatment, be mainly used in cereal, paddy rice, peanut, grape, potato, fruit tree, vegetables, coffee, lawn etc.Fluoxastrobin has control efficiency to all fungal diseases of plants; but because its growth metabolism feature of different germs is different; Fluoxastrobin is a bactericide with the double therapeutic action of prevention, but its strongest advantage is preventive effect, instead of its therapeutic action.Their effect is also not quite similar.
Tricyclazole is the systemic fungicide being exclusively used in control rice blast, good to panicle blast control efficiency especially.The infection point infected plant surface by suppressing Pyricularia oryzae and formed in plant stops rice blast to circulate.The Pyricularia oryzae other bactericide being produced to resistance is also effective.Because medicament also has a protective fungicide effect, should use before disease occurs.
Fluoxastrobin of the present invention and the composite suspending agent of tricyclazole, its beneficial effect shows:
1) suspending agent that, prepared by the present invention is all obviously better than the product prepared by other proportionings in suspensibility, wet screening test etc. and heat storage stability etc.
2), verify by experiment, Fluoxastrobin and tricyclazole with 1:3 proportioning mixed composite 40% time Fluoxastrobin and the composite suspending agent of tricyclazole, notable synergistic sphere of action can be played, and the preparation that other proportioning is mixed, all cannot reach notable synergistic sphere of action.Meanwhile, the actual toxicity of different ratio does not promote along with the enhancing of theoretical toxicity, there is no regular change between actual toxicity and theoretical toxicity.
Another object of the present invention is to the preparation method that a kind of Fluoxastrobin and the composite suspending agent of tricyclazole are provided, just grind after raw material suction preparation still mix and blend through colloid mill, then through sand mill fine grinding, sample analysis, qualified rear filtration, metering, packaging, warehouse-in.
The preparation method of Fluoxastrobin of the present invention and the composite suspending agent of tricyclazole, preparation technology is comparatively easy, is easy to suitability for industrialized production.
Embodiment
Below with reference to embodiment, the present invention is described in detail.But; embodiment content is only citing made for the present invention and explanation; affiliated those skilled in the art make various amendment to described specific embodiment or supplement or adopt similar mode to substitute; only otherwise depart from the design of invention or surmount this scope as defined in the claims, protection scope of the present invention all should be belonged to.
One, the preparation of Fluoxastrobin and the composite suspending agent of tricyclazole, and testing result, the heat storage stability result of the test of all technical of suspending agent prepared by each embodiment.
Embodiment 1
40% Fluoxastrobin and the composite suspending agent of tricyclazole, each component and weight portion as follows:
| Composition | Weight portion |
| Fluoxastrobin | 10 |
| Tricyclazole | 30 |
| Fatty alcohol-polyoxyethylene ether | 3 |
| Styrylphenol polyoxyethylene ether | 5 |
| Xanthans | 0.5 |
| Sodium Benzoate | 0.3 |
| Defoamer | 0.5 2 --> |
| Deionized water | 50.7 |
Preparation method: just grind after raw material suction preparation still mix and blend through colloid mill, then through sand mill fine grinding, sample analysis, qualified rear filtration, metering, packaging, warehouse-in.
Embodiment 2
40.5% Fluoxastrobin and the composite suspending agent of tricyclazole, each component and weight portion as follows:
| Composition | Weight portion |
| Fluoxastrobin | 10.5 |
| Tricyclazole | 30 |
| Fatty alcohol-polyoxyethylene ether | 3 |
| Styrylphenol polyoxyethylene ether | 5 |
| Xanthans | 0.5 |
| Sodium Benzoate | 0.3 |
| Defoamer | 0.5 |
| Deionized water | 50.2 |
Preparation method is with embodiment 1.
Embodiment 3
41% Fluoxastrobin and the composite suspending agent of tricyclazole, each component and weight portion as follows:
Preparation method is with embodiment 1.
Embodiment 4
39.5% Fluoxastrobin and the composite suspending agent of tricyclazole, each component and weight portion as follows:
| Composition | Weight portion |
| Fluoxastrobin | 10 3 --> |
| Tricyclazole | 29.5 |
| Fatty alcohol-polyoxyethylene ether | 3 |
| Styrylphenol polyoxyethylene ether | 5 |
| Xanthans | 0.5 |
| Sodium Benzoate | 0.3 |
| Defoamer | 0.5 |
| Deionized water | 51.2 |
Preparation method is with embodiment 1.
Embodiment 5
39% Fluoxastrobin and the composite suspending agent of tricyclazole, each component and weight portion as follows:
| Composition | Weight portion |
| Fluoxastrobin | 9.5 |
| Tricyclazole | 29.5 |
| Fatty alcohol-polyoxyethylene ether | 3 |
| Styrylphenol polyoxyethylene ether | 5 |
| Xanthans | 0.5 |
| Sodium Benzoate | 0.3 |
| Defoamer | 0.5 |
| Deionized water | 51.7 |
Preparation method is with embodiment 1.
Fluoxastrobin prepared by embodiment 1 ~ 5 and the composite suspending agent of tricyclazole, the testing result of product all technical is as shown in table 1, and product heat storage stability result of the test is as shown in table 2.
The testing result of a table 15 embodiment preparing product all technical
A table 25 embodiment preparing product heat storage stability result of the test
Can be found out by table 1 and 2, product prepared by embodiment 1 is all obviously better than the product prepared by other embodiments in suspensibility, wet screening test etc. and heat storage stability etc.
Two, toxicological information
Fluoxastrobin: rat acute per os LD
50> 5000mg/kg, belongs to malicious class such as low grade; Rat acute is through skin LD
50> 2000mg/kg, belongs to malicious class such as low grade.
Tricyclazole: rat acute per os LD
50for 305mg/kg, chmice acute per os LD
50for 250mg/kg, rat acute is through skin LD
50> 2000mg/kg, rat acute sucks LC
50> 0.25mg/m
3, have slight spread effect to lagophthalmos and skin, without chronic toxicity under test dose.
Three, the indoor biological activity (virulence) of Fluoxastrobin and the composite suspending agent of tricyclazole measures.
1, experiment purpose
Be intended to measure Fluoxastrobin, tricyclazole and the two different proportion proportioning to the virulence of rice blast, to judge whether the two different ratio has synergistic effect to suppression rice blast.
2, experimental condition
2.1 for examination target
Pyricularia oryzae (PowderyMildews) test strain, is provided by Zhi Bing teaching and research room of Agricultural University Of Anhui.
2.2 condition of culture
By the Pyricularia oryzae strain transfer of indoor 4 DEG C of Refrigerator stores on PSA medium, cultivate in 25 DEG C of incubators and make it activate, for subsequent use after twice switching.
2.3 instrument and equipment
Electronic balance (sensibility reciprocal 0.1mg), test tube, culture dish, pressure steam sterilizer, superclean bench, biochemical cultivation case, pipettor, inoculator, card punch (internal diameter is 5mm) etc.
3, experimental scheme
3.1 examination materials prepare
Pyricularia oryzae pathogen is placed in biochemical cultivation case and cultivates, for subsequent use.
3.2 medicament
95% Fluoxastrobin (azoxystrobin) former medicine, Anhui methylene blue Agrochemicals limited company provides;
95% tricyclazole (tricyclazole) former medicine, Anhui methylene blue Agrochemicals limited company provides.
3.3 medicament preparations
5 series mass concentration are diluted to the medicament that embodiment 1-5 is prepared by acetone.
4, test method
Carry out with reference to " farm-chemical indoor determination test rule----bactericide " (NY/T1156.6-2006).In order to grope the activity of each medicament to strains tested, first carry out preliminary experiment.Cultivate be placed on the medium containing higher and low concentration medicament by mycelia under, estimate EC
50, and then according to the EC estimated
50value, is made into its EC by medium
50the pastille medium of the variable concentrations gradient of left and right is cultivated.
This test adopts plate mycelial growth rate method to measure medicament to the virulence of Pyricularia oryzae.Concrete grammar is as follows: through the Pyricularia oryzae bacterial strain PSA medium culture of switching activation, when bacterium colony grows to culture dish 3/4ths size, punch from edge with the card punch that internal diameter is 5mm, the mycelia block broken into is as inoculum.Respectively medicament mother liquor is added in the PSA medium of people's sterilizing thawing, fully shake up, make medicament ultimate density (calculating by active ingredient) reach variable concentrations gradient (table 1).About 15mL pastille medium poured into by every ware, if not dosing is contrast, often processes 4 repetitions.Move the mycelia block (diameter 5mm) connecing new growth central in flat board, be placed in 25 DEG C of incubators and cultivate 2d (Pyricularia oryzae), 7d (Pyricularia oryzae) and 15d (Pyricularia oryzae).Measure colony diameter by right-angled intersection method, calculate each process net growth, mycelial growth inhibition rate.
In formula: bacterium dish diameter is 5mm.
5, data statistic analysis
Mycelial growth inhibition rate is converted into probit value (y), and drug concentration (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares.With DPS statistical software, regression analysis is carried out to the log concentration value of each single dose and different mixture and corresponding inhibiting rate probit value, calculate EC
50value and 95% confidence limit.
According to EC
50calculate the actual measurement toxicity index (ATI) of built agent, theoretical toxicity index (TTI) and co-toxicity coefficient (CTC).
Built agent actual measurement toxicity index (ATI)=single dose EC
50/ built agent EC
50× 100
Theoretical toxicity index (TTI)=A toxicity index × A content (%)+B toxicity index × B content (the %)+C toxicity index × C content (%) in built agent in built agent in built agent of built agent
Co-toxicity coefficient (CTC)=ATI/TTI × 100
Calculate medicament different ratio synergy ratio (CTC) according to the abundant method of Sun Yun, CTC≤80 are antagonism, and 80 < CTC < 120 are summation action, and CTC >=120 are synergistic effect.
6, results and analysis
The co-toxicity of suspending agent to rice blast prepared by embodiment 1 shows as notable synergistic effect (co-toxicity coefficient reaches 274), and suspending agent prepared by embodiment 2-5 only shows as summation action (co-toxicity coefficient is followed successively by 82,92,87,93) to the co-toxicity of rice blast.
Claims (2)
1. Fluoxastrobin and the composite suspending agent of tricyclazole, is characterized in that: be made up of the component of following weight portion:
2. prepare the method for Fluoxastrobin and the composite suspending agent of tricyclazole as claimed in claim 1 for one kind, it is characterized in that: just grind after raw material suction preparation still mix and blend through colloid mill, again through sand mill fine grinding, sample analysis, qualified rear filtration, metering, packaging, warehouse-in.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510997696.4A CN105519548A (en) | 2015-12-24 | 2015-12-24 | Azoxystrobin and tricyclazole compounded suspension and preparation method thereof |
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|---|---|---|---|
| CN201510997696.4A CN105519548A (en) | 2015-12-24 | 2015-12-24 | Azoxystrobin and tricyclazole compounded suspension and preparation method thereof |
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|---|---|
| CN105519548A true CN105519548A (en) | 2016-04-27 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019215593A1 (en) * | 2018-05-07 | 2019-11-14 | Indofil Industries Limited | Synergistic fungicidal composition and a process for preparation thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1561725A (en) * | 2004-03-18 | 2005-01-12 | 南京农业大学 | Built agent for preventing and control rice blast |
| CN103814908A (en) * | 2012-11-16 | 2014-05-28 | 季爱英 | Composite agricultural fungicide |
-
2015
- 2015-12-24 CN CN201510997696.4A patent/CN105519548A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1561725A (en) * | 2004-03-18 | 2005-01-12 | 南京农业大学 | Built agent for preventing and control rice blast |
| CN103814908A (en) * | 2012-11-16 | 2014-05-28 | 季爱英 | Composite agricultural fungicide |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019215593A1 (en) * | 2018-05-07 | 2019-11-14 | Indofil Industries Limited | Synergistic fungicidal composition and a process for preparation thereof |
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Application publication date: 20160427 |
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