CN105503906B - 一种三唑并吡嗪衍生物a晶型及其制备方法 - Google Patents
一种三唑并吡嗪衍生物a晶型及其制备方法 Download PDFInfo
- Publication number
- CN105503906B CN105503906B CN201510906993.3A CN201510906993A CN105503906B CN 105503906 B CN105503906 B CN 105503906B CN 201510906993 A CN201510906993 A CN 201510906993A CN 105503906 B CN105503906 B CN 105503906B
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- CN
- China
- Prior art keywords
- organic solvent
- oxazine derivatives
- crystal forms
- triazolopyridine oxazine
- triazolopyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
实施例 | 溶剂 | 收率 |
1 | 正丙醇 | 80% |
2 | 异丙醇 | 81% |
3 | 乙酸乙酯 | 83% |
4 | 正庚烷 | 85% |
5 | 乙腈 | 87% |
6 | 丙酮 | 82% |
7 | 甲苯 | 85% |
8 | 四氢呋喃 | 86% |
9 | 二氯甲烷 | 87% |
实施例 | 溶剂 | 收率 |
10 | 乙醇 | 60% |
11 | 正丙醇 | 67% |
12 | 乙酸乙酯 | 56% |
13 | 丙酮 | 65% |
14 | 异丙醚 | 70% |
15 | 甲苯 | 67% |
Claims (15)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510906993.3A CN105503906B (zh) | 2015-12-09 | 2015-12-09 | 一种三唑并吡嗪衍生物a晶型及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510906993.3A CN105503906B (zh) | 2015-12-09 | 2015-12-09 | 一种三唑并吡嗪衍生物a晶型及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105503906A CN105503906A (zh) | 2016-04-20 |
CN105503906B true CN105503906B (zh) | 2018-09-11 |
Family
ID=55712264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201510906993.3A Ceased CN105503906B (zh) | 2015-12-09 | 2015-12-09 | 一种三唑并吡嗪衍生物a晶型及其制备方法 |
Country Status (1)
Country | Link |
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CN (1) | CN105503906B (zh) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102127096A (zh) * | 2009-12-31 | 2011-07-20 | 和记黄埔医药(上海)有限公司 | 三氮唑并吡啶和三氮唑并吡嗪化合物及其组合物和应用 |
WO2014135876A1 (en) * | 2013-03-06 | 2014-09-12 | Astrazeneca Ab | Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor |
-
2015
- 2015-12-09 CN CN201510906993.3A patent/CN105503906B/zh not_active Ceased
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102127096A (zh) * | 2009-12-31 | 2011-07-20 | 和记黄埔医药(上海)有限公司 | 三氮唑并吡啶和三氮唑并吡嗪化合物及其组合物和应用 |
WO2014135876A1 (en) * | 2013-03-06 | 2014-09-12 | Astrazeneca Ab | Quinazoline inhibitors of activating mutant forms of epidermal growth factor receptor |
Non-Patent Citations (2)
Title |
---|
Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine as a Highly Potent and Selective Mesenchymal-Epithelial Transition Factor Inhibitor in Clinical Development for Treatment of Cancer;Hong Jia等;《J. Med. Chem.》;20140822;第57卷(第18期);第7577-7589页,尤其摘要,Table5,第7582页右栏,Scheme 4-5,第7584页左栏第一段,第7585页右栏倒数第二段 * |
The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient–Derived Xenograft Models;Alwin G. Schuller等;《Clinical Cancer Research》;20150316;第21卷(第12期);第2811-2819页 * |
Also Published As
Publication number | Publication date |
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CN105503906A (zh) | 2016-04-20 |
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CB03 | Change of inventor or designer information |
Inventor after: Ren Guobin Inventor after: Ge Dongxu Inventor after: Chen Jinyao Inventor before: Ren Guobin Inventor before: Ge Dongxu Inventor before: Chen Jinyao |
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CB02 | Change of applicant information |
Address after: 201207 Shanghai City, Pudong New Area Chinese (Shanghai) free trade zone fanchun Road No. 400 Building 1 layer 3 Applicant after: SHANGHAI XUANCHUANG BIOLOGICAL SCIENCE & TECHNOLOGY CO., LTD. Address before: 200072 Shanghai city Jiading District Fu Road No. 1011 A District 1309 room 3 Office Applicant before: SHANGHAI XUANCHUANG BIOLOGICAL SCIENCE & TECHNOLOGY CO., LTD. |
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GR01 | Patent grant | ||
GR01 | Patent grant | ||
IW01 | Full invalidation of patent right |
Decision date of declaring invalidation: 20190802 Decision number of declaring invalidation: 41253 Granted publication date: 20180911 |
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