CN105497845A - 治疗踝关节扭伤的外用膏剂及其制备方法 - Google Patents
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Abstract
本发明公开了一种治疗踝关节扭伤的外用膏剂,取下述重量配比的主要原料制备而成:生川乌15-25份,川芎10-20份,八角莲20-30份,当归8-16份,穿山龙3-9份,骨碎补8-20份,红花9-18份,续断4-12份,五倍子12-18份,马齿笕5-13份,鲜生姜20-30份,鲜土豆5-13份,半枝莲9-23份。本发明具有舒筋活血、活血祛瘀之功效,用于治疗踝关节扭伤、半月板损伤、颈椎病以及骨折。
Description
技术领域
本发明涉及中医中药领域,特别是涉及一种治疗踝关节扭伤的外用膏剂及制法。
背景技术
踝关节扭伤是临床常见的疾病,在关节及韧带损伤中是发病率最高的疾病。踝关节是人体距离地面最近的负重关节,也就是说踝关节是全身负重最多的关节。踝关节的稳定性对于日常的活动和体育运动的正常进行起重要的作用。踝关节周围的韧带损伤都属于踝关节扭伤的范畴。踝关节扭伤可能导致的损伤包括外踝的距腓前韧带跟腓韧带,内踝三角韧带,下胫腓横韧带等。
病因:踝关节扭伤是最高发的运动损伤,约占所有运动损伤的40%。踝关节由胫骨腓骨远端和距骨构成。由内外踝和胫骨后缘构成踝穴,距骨上面的鞍型关节面位于踝穴中。距骨的鞍型关节面前宽后窄,背伸时较宽处进入踝穴,跖屈时较窄部进入踝穴,所以踝关节在跖屈位稍松动,其解剖和生理特点决定踝关节在跖屈时比较容易发生内翻外翻扭伤。又因为踝关节外踝腓骨较长踝穴较深而内踝胫骨较短踝穴较浅,故踝关节更易发生内翻扭伤,外踝韧带包括距腓前韧带及跟腓韧带的损伤更常见。踝关节外翻扭伤虽不易发生,一旦出现却很严重。如发生断裂一般都会引起踝关节不稳,且多同时合并其他韧带损伤和骨折。
临床表现:踝关节扭伤的临床表现包括伤后迅即出现扭伤部位的疼痛和肿胀,随后出现皮肤淤斑。严重者患足因为疼痛肿胀而不能活动。外踝扭伤时,患者在尝试行足内翻时疼痛症状加剧。内侧三角韧带损伤时,患者在尝试行足外翻时疼痛症状加剧。经休息后疼痛和肿胀可能消失,会出现因韧带松弛导致的踝关节不稳,反复扭伤。随着经济的发展,中药在治疗踝关节扭伤非常重要,但是还存在着一些弊端,疗效还不确切。
发明内容
针对现有技术的不足,本发明的目的之一在于提供一种治疗踝关节扭伤的外用膏剂,具有补脾益气、养血活血、舒肝理气的功效,且本发明药材药源易得,成本低廉,所选药材多为药性平和之物。
本发明的另一目的就是提供上述外用膏剂的制备方法。
本发明的技术方案是:
治疗踝关节扭伤的外用膏剂,取下述重量配比的主要原料制备而成:生川乌15-25份,川芎10-20份,八角莲20-30份,当归8-16份,穿山龙3-9份,骨碎补8-20份,红花9-18份,续断4-12份,五倍子12-18份,马齿笕5-13份,鲜生姜20-30份,鲜土豆5-13份,半枝莲9-23份。
治疗踝关节扭伤的外用膏剂,优选的方案为,取下述重量配比的主要原料制备而成:生川乌18-23份,川芎13-18份,八角莲23-28份,当归10-14份,穿山龙5-7份,骨碎补14-18份,红花13-15份,续断7-9份,五倍子14-16份,马齿笕8-10份,鲜生姜23-28份,鲜土豆8-10份,半枝莲14-19份。
治疗踝关节扭伤的外用膏剂,更为优选的方案为,取下述重量配比的主要原料制备而成:生川乌20份,川芎16份,八角莲25份,当归12份,穿山龙6份,骨碎补16份,红花14份,续断8份,五倍子15份,马齿笕9份,鲜生姜25份,鲜土豆9份,半枝莲17份。
上述治疗踝关节扭伤的外用膏剂的制备方法,步骤如下:
(1)将马齿笕、鲜生姜和鲜土豆洗净,先切丝在切小丁,置于纱布内,捣碎取汁液,将汁液在120-140℃下灭菌20-40秒,用保鲜膜包裹静置待用;
(2)将生川乌、川芎、八角莲、当归和穿山龙置于特质的容器内,放入淡盐水,在淡盐水中浸泡2-4小时,武火煮沸,转文火熬制45-65分钟,过滤,滤液待用;
(3)将骨碎补、红花、续断、五倍子和半枝莲放入锅内,用盐炒2-6分钟,炒至散发出香味后晾凉,研磨成细末过80-120目筛待用;
(4)将步骤(1)-(3)所得物混匀,一边煎煮一边搅拌10-20分钟放入白凡士林,充分搅拌均匀,晾凉分装即可。
根据前面所述的制备方法,优选的方案在于:步骤(1)汁液在125-135℃下灭菌25-35秒(优选汁液在130℃下灭菌30秒)。
根据前面所述的制备方法,优选的方案在于:步骤(2)淡盐水的用量是生川乌、川芎、八角莲、当归和穿山龙总重量的2-4倍(优选的,淡盐水的用量是生川乌、川芎、八角莲、当归和穿山龙总重量的2.5-3.5倍,更佳优选的,淡盐水的用量是生川乌、川芎、八角莲、当归和穿山龙总重量的3倍)。
根据前面所述的制备方法,优选的方案在于:步骤(2)在淡盐水中浸泡2.5-3.5小时(优选在淡盐水中浸泡3小时)。
根据前面所述的制备方法,优选的方案在于:步骤(2)武火煮沸,转文火熬制50-60分钟(优选的,武火煮沸,转文火熬制55分钟)。
根据前面所述的制备方法,优选的方案在于:步骤(3)研磨成细末过90-110目筛待用(优选研磨成细末过100目筛待用)。
根据前面所述的制备方法,优选的方案在于:步骤(4)一边煎煮一边搅拌13-18分钟放入白凡士林(优选一边煎煮一边搅拌15分钟放入白凡士林)。
最佳使用方法:为使本发明达到最佳的治疗效果,为使本发明达到最佳治疗效果,本发明制成的外用膏剂,抹于扭伤部位的体表,每日两次,于早上起床前以及晚上睡觉前涂抹,10天为一个疗程。
各原料药的药理功效分别为:
生川乌:祛风除湿,温经止痛。用于风寒湿痹、关节疼痛、心腹冷痛、寒疝作痛。用于治疗风寒湿痹、关节疼痛等病症。一般炮制后内服。生川乌酊外用能刺激皮肤,继而产生麻木感,故外用作某些神经痛及风湿的镇痛剂。
川芎:常用于活血行气,祛风止痛,当归辛温香燥,走而不守,既能行散,上行可达巅顶;又入血分,下行可达血海。活血祛瘀作用广泛,适宜瘀血阻滞各种病症;祛风止痛,效用甚佳,可治头风头痛、风湿痹痛等症。昔人谓当归为血中之气药,殆言其寓辛散、解郁、通达、止痛等功能。
八角莲:为小檗科八角莲属植物八角莲、六角莲和川八角莲的根及根茎。成分:1.八角莲根茎含木脂素:鬼臼毒素,鬼臼苦素;黄酮类:山荷叶素山奈酚,槲皮素等。2.六角莲根茎含木脂素:鬼臼毒素,去氢鬼臼毒素,鬼臼毒酮等。3.川八角莲根含去氧鬼臼毒素,β-盾叶鬼臼素,鬼臼毒素,山奈酚-3-β-D-葡萄糖苷,葡萄糖,蔗糖及β-谷甾醇。药性:苦、辛,温。有毒。归肺、肝经。功用主治:化痰解毒,祛瘀散结。主治咳嗽,咽喉肿痛,瘰疬,瘿瘤,无名肿痛,带状疱疹,毒蛇咬伤,跌打损伤,风湿痹痛。
当归:补血;活血;调经止痛;润燥滑肠。主血虚诸证;月经不调;经闭;痛经;症瘕结聚;崩漏;虚寒腹痛;痿痹;肌肤麻木;肠燥便难;赤痢后重;痈疽疮疡;跌扑损伤。
穿山龙:别名穿地龙、串地龙、穿龙骨、地龙骨、金刚骨、鸡骨头、山常山、常山、爬山虎、鞭梢菜。性味功效:苦,平。归肝、肺经。功能活血舒筋,怯风止痛,止咳平喘,怯痰。适用于腰腿疼痛、筋骨麻木、跌打损伤、闪腰岔气、咳嗽喘息。骨碎补:苦,平。行血通经,催生下乳,消肿敛疮。治妇女经闭,乳汁不通,难产,血淋,痈肿,金疮出血。
骨碎补:补肾强骨,续伤止痛。用于肾虚腰痛,耳鸣耳聋,牙齿松动,跌扑闪挫,筋骨折伤;外治斑秃,白癜风。
红花:入肝、肾二经。功能主治:活血通经,去瘀止痛。治经闭,症瘕,难产,死胎,产后恶露不行、瘀血作痛,痈肿,跌扑损伤。
续断:补肝肾,续筋骨,调血脉。治腰背酸痛,足膝无力,胎漏,崩漏,带下,遗精,跌打损伤,金疮,痔漏,痈疽疮肿。
五倍子:中药材五倍子为漆树科植物盐肤木、青麸杨或红麸杨叶上的干燥虫瘿,主要由五倍子蚜寄生而形成。其性寒,味酸、涩,具有敛肺降火、涩肠止泻、敛汗止血、收湿敛疮等功效,主治肺虚久咳、久泻久痢、便血痔血、痈肿疮毒、皮肤湿烂等症。
马齿笕:性味:性寒,味甘酸。归经:入心经、肝经、脾经、大肠经。功能:清热解毒、凉血止血。主治:热毒泻痢、热淋、尿闭、赤白带下、崩漏、痔血、疮疡痈疖、丹毒、瘰疬、湿癣、白秃、痢疾(大便半干半稀)、热毒血痢、痈肿疔疮、湿疹、蛇虫咬伤、便血、崩漏下血、现代大多用于治疗肠炎、急性关节炎、膀胱炎、尿道炎、肛门炎、痔疮出血等。
鲜生姜:生姜皮性辛凉,治皮肤浮肿,行皮水;生姜汁辛温,辛散胃寒力量强,多用于呕吐;干姜辛温,温中煽动寒,回阳通脉,温脾寒力量大,炮姜味辛苦走里不走表,温下焦之寒;炮姜炭性温,偏于温血分之寒;煨姜苦温,偏于温肠胃之寒。生姜辛而散温,益脾胃,善温中降逆止呕,除湿消痞,止咳祛痰,以降逆止呕为长。
鲜土豆:可以用来主治胃痛、痄肋、痈肿、湿疹、烫伤,是和胃健中药和解毒消肿药,性平味甘。中医认为马铃薯“性平味甘无毒,能健脾和胃,益气调中,缓急止痛,通利大便。对脾胃虚弱、消化不良、肠胃不和、脘腹作痛、大便不畅的患者效果显著”。现代研究证明,马铃薯对调解消化不良有特效,是胃病和心脏病患者的良药及优质保健品。马铃薯富有营养,是抗衰老的食物之一。
半枝莲:半支莲全草入药,具有清热解毒、活血祛瘀、消肿止痛、抗癌等功能。性寒味酸,全草含多种维生素、微量元素及氨基酸等成分。有凉血解毒,散瘀止痛,消肿和清热利湿之功效。
本发明具有舒筋活血、活血祛瘀之功效,用于治疗踝关节扭伤、半月板损伤、颈椎病以及骨折。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案,但保护范围不被此限制。
实施例1:治疗踝关节扭伤的外用膏剂,取下述重量配比的主要原料制备而成(每份取10g):生川乌15份,川芎10份,八角莲20份,当归8份,穿山龙3份,骨碎补8份,红花9份,续断4份,五倍子12份,马齿笕5份,鲜生姜20份,鲜土豆5份,半枝莲9份。
上述治疗踝关节扭伤的外用膏剂的制备方法,步骤如下:
(1)将马齿笕、鲜生姜和鲜土豆洗净,先切丝在切小丁,置于纱布内,捣碎取汁液,将汁液在120℃下灭菌20秒,用保鲜膜包裹静置待用;
(2)将生川乌、川芎、八角莲、当归和穿山龙置于特质的容器内,放入淡盐水,在淡盐水中浸泡2小时,武火煮沸,转文火熬制45分钟,过滤,滤液待用;
(3)将骨碎补、红花、续断、五倍子和半枝莲放入锅内,用盐炒2分钟,炒至散发出香味后晾凉,研磨成细末过80目筛待用;
(4)将步骤(1)-(3)所得物混匀,一边煎煮一边搅拌10分钟放入白凡士林,充分搅拌均匀,晾凉分装即可。
典型案例一:田XX,女,30岁,山东省济南市人,2011年8月患者来诊,患者自述,在上楼梯时,不小心踩空,当时跌倒在地,入院检查时右下肢体无畸形,踝关节肿胀,局部皮肤无发红,未见瘀斑片,皮温稍高,内外踝压痛,踝关节活动受限,未触及骨擦感,末梢血运、感觉良好,右下肢体肌力、肌张力正常,膝髋关节活动未见异常,余肢体亦未见异常,给予使用本发明所得外用膏剂。
使用本发明实施例1所得外用10天,疼痛减轻,下肢有力气了,继续治疗10天,患者自感痊愈,停药后没有不良反应。
实施例2治疗踝关节扭伤的外用膏剂,取下述重量配比的主要原料制备而成(每份取5g):生川乌25份,川芎20份,八角莲30份,当归16份,穿山龙9份,骨碎补20份,红花18份,续断12份,五倍子18份,马齿笕13份,鲜生姜30份,鲜土豆13份,半枝莲23份。
上述治疗踝关节扭伤的外用膏剂的制备方法,步骤如下:
(1)将马齿笕、鲜生姜和鲜土豆洗净,先切丝在切小丁,置于纱布内,捣碎取汁液,将汁液在140℃下灭菌40秒,用保鲜膜包裹静置待用;
(2)将生川乌、川芎、八角莲、当归和穿山龙置于特质的容器内,放入淡盐水,在淡盐水中浸泡4小时,武火煮沸,转文火熬制65分钟,过滤,滤液待用;
(3)将骨碎补、红花、续断、五倍子和半枝莲放入锅内,用盐炒6分钟,炒至散发出香味后晾凉,研磨成细末过120目筛待用;
(4)将步骤(1)-(3)所得物混匀,一边煎煮一边搅拌20分钟放入白凡士林,充分搅拌均匀,晾凉分装即可。
实施例3治疗踝关节扭伤的外用膏剂,取下述重量配比的主要原料制备而成(每份取15g):生川乌18份,川芎13份,八角莲23份,当归10份,穿山龙5份,骨碎补14份,红花13份,续断7份,五倍子14份,马齿笕8份,鲜生姜23份,鲜土豆8份,半枝莲14份。
上述治疗踝关节扭伤的外用膏剂的制备方法,步骤如下:
(1)将马齿笕、鲜生姜和鲜土豆洗净,先切丝在切小丁,置于纱布内,捣碎取汁液,将汁液在125℃下灭菌25秒,用保鲜膜包裹静置待用;
(2)将生川乌、川芎、八角莲、当归和穿山龙置于特质的容器内,放入淡盐水,在淡盐水中浸泡2.5小时,武火煮沸,转文火熬制50分钟,过滤,滤液待用;
(3)将骨碎补、红花、续断、五倍子和半枝莲放入锅内,用盐炒3分钟,炒至散发出香味后晾凉,研磨成细末过90目筛待用;
(4)将步骤(1)-(3)所得物混匀,一边煎煮一边搅拌13分钟放入白凡士林,充分搅拌均匀,晾凉分装即可。
实施例4治疗踝关节扭伤的外用膏剂,取下述重量配比的主要原料制备而成(每份取20g):生川乌23份,川芎18份,八角莲28份,当归14份,穿山龙7份,骨碎补18份,红花15份,续断9份,五倍子16份,马齿笕10份,鲜生姜28份,鲜土豆10份,半枝莲19份。
上述治疗踝关节扭伤的外用膏剂的制备方法,步骤如下:
(1)将马齿笕、鲜生姜和鲜土豆洗净,先切丝在切小丁,置于纱布内,捣碎取汁液,将汁液在135℃下灭菌35秒,用保鲜膜包裹静置待用;
(2)将生川乌、川芎、八角莲、当归和穿山龙置于特质的容器内,放入淡盐水,在淡盐水中浸泡3.5小时,武火煮沸,转文火熬制60分钟,过滤,滤液待用;
(3)将骨碎补、红花、续断、五倍子和半枝莲放入锅内,用盐炒5分钟,炒至散发出香味后晾凉,研磨成细末过110目筛待用;
(4)将步骤(1)-(3)所得物混匀,一边煎煮一边搅拌18分钟放入白凡士林,充分搅拌均匀,晾凉分装即可。
典型案例二:王XX,男,18岁,黑龙江人士,某高中的学生,在学校的体育课上,与其他的班级踢足球,不慎摔倒在地,入院检查时右下肢体无畸形,踝关节肿胀,局部皮肤无发红,脚持续疼痛,明显感觉脚骨偏了个包,但是医生说看CT骨头没有问题,未见瘀斑片,皮温稍高,内外踝压痛,踝关节活动受限,未触及骨擦感,末梢血运、感觉良好,右下肢体肌力、肌张力正常,膝髋关节活动未见异常,余肢体亦未见异常,给予使用本发明所得外用膏剂。
使用本发明实施例4所得外用10天,疼痛减轻,下肢有力气了,继续治疗10天,患者自感痊愈,停药后没有不良反应。
实施例5治疗踝关节扭伤的外用膏剂,取下述重量配比的主要原料制备而成(每份取30g):生川乌20份,川芎16份,八角莲25份,当归12份,穿山龙6份,骨碎补16份,红花14份,续断8份,五倍子15份,马齿笕9份,鲜生姜25份,鲜土豆9份,半枝莲17份。
上述治疗踝关节扭伤的外用膏剂的制备方法,步骤如下:
(1)将马齿笕、鲜生姜和鲜土豆洗净,先切丝在切小丁,置于纱布内,捣碎取汁液,将汁液在130℃下灭菌30秒,用保鲜膜包裹静置待用;
(2)将生川乌、川芎、八角莲、当归和穿山龙置于特质的容器内,放入淡盐水,在淡盐水中浸泡3小时,武火煮沸,转文火熬制55分钟,过滤,滤液待用;
(3)将骨碎补、红花、续断、五倍子和半枝莲放入锅内,用盐炒4分钟,炒至散发出香味后晾凉,研磨成细末过100目筛待用;
(4)将步骤(1)-(3)所得物混匀,一边煎煮一边搅拌15分钟放入白凡士林,充分搅拌均匀,晾凉分装即可。
试验例1实施例5所得治疗踝关节扭伤的外用膏剂临床应用:2011年12月-2014年1月,在4所医院筛选120例患者,试验之前,对该人群进行连续观察,记录症状及变化,实验组100人,对照组20人,实验组使用本发明所得产品,对照组使用其它药品。
使用方法为:为使本发明达到最佳的治疗效果,本发明制成的外用膏剂,抹于扭伤部位的体表,每日两次,于早上起床前以及晚上睡觉前涂抹,10天为一个疗程。
治愈:使用本品后,不适症状消失;有效:使用本品后,不适症状基本消失;无效:使用本品后,不适症状无明显变化,患者病症与治疗前无明显差异。结果如表1所示。结果如表1所示。
表1:
使用期间自感症状及乳房疼痛变化如表2所示。
表2:
疗效分析:给药组使用10天时大多数病人感觉症状明显减轻,患处明显感觉有好转,病人情绪好转,用药20天时病人基本痊愈,病情得到较好控制。用药30天时,患者的不适症状消失,自感痊愈,对照组服药后治愈效果明显,但是停药后复发率高。
经临床试验证明,本发明中药制剂在治疗踝关节扭伤上,总有效率为99%,治愈率为95%,比对照组的总有效率高出39%,治愈率高出45%,且能够彻底去除病根,使患者真正的痊愈;且不会对患者的身体造成任何负担。本发明中药制剂见效快,能够达到迅速缓解病人痛苦的目的,且复发率低,是一种安全有效的治疗踝关节扭伤的中药制剂。
Claims (10)
1.治疗踝关节扭伤的外用膏剂,其特征在于:取下述重量配比的主要原料制备而成:生川乌15-25份,川芎10-20份,八角莲20-30份,当归8-16份,穿山龙3-9份,骨碎补8-20份,红花9-18份,续断4-12份,五倍子12-18份,马齿笕5-13份,鲜生姜20-30份,鲜土豆5-13份,半枝莲9-23份。
2.根据权利要求1所述的治疗踝关节扭伤的外用膏剂,其特征在于:取下述重量配比的主要原料制备而成:生川乌18-23份,川芎13-18份,八角莲23-28份,当归10-14份,穿山龙5-7份,骨碎补14-18份,红花13-15份,续断7-9份,五倍子14-16份,马齿笕8-10份,鲜生姜23-28份,鲜土豆8-10份,半枝莲14-19份。
3.根据权利要求1所述的治疗踝关节扭伤的外用膏剂,其特征在于:取下述重量配比的主要原料制备而成:生川乌20份,川芎16份,八角莲25份,当归12份,穿山龙6份,骨碎补16份,红花14份,续断8份,五倍子15份,马齿笕9份,鲜生姜25份,鲜土豆9份,半枝莲17份。
4.根据权利要求1-3任一项所述的治疗踝关节扭伤的外用膏剂的制备方法,其特征在于:步骤如下:
(1)将马齿笕、鲜生姜和鲜土豆洗净,先切丝在切小丁,置于纱布内,捣碎取汁液,将汁液在120-140℃下灭菌20-40秒,用保鲜膜包裹静置待用;
(2)将生川乌、川芎、八角莲、当归和穿山龙置于特质的容器内,放入淡盐水,在淡盐水中浸泡2-4小时,武火煮沸,转文火熬制45-65分钟,过滤,滤液待用;
(3)将骨碎补、红花、续断、五倍子和半枝莲放入锅内,用盐炒2-6分钟,炒至散发出香味后晾凉,研磨成细末过80-120目筛待用;
(4)将步骤(1)-(3)所得物混匀,一边煎煮一边搅拌10-20分钟放入白凡士林,充分搅拌均匀,晾凉分装即可。
5.根据权利要求4所述的制备方法,其特征在于:步骤(1)汁液在125-135℃下灭菌25-35秒(优选汁液在130℃下灭菌30秒)。
6.根据权利要求4所述的制备方法,其特征在于:步骤(2)淡盐水的用量是生川乌、川芎、八角莲、当归和穿山龙总重量的2-4倍(优选的,淡盐水的用量是生川乌、川芎、八角莲、当归和穿山龙总重量的2.5-3.5倍,更佳优选的,淡盐水的用量是生川乌、川芎、八角莲、当归和穿山龙总重量的3倍)。
7.根据权利要求4所述的制备方法,其特征在于:步骤(2)在淡盐水中浸泡2.5-3.5小时(优选在淡盐水中浸泡3小时)。
8.根据权利要求4所述的制备方法,其特征在于:步骤(2)武火煮沸,转文火熬制50-60分钟(优选的,武火煮沸,转文火熬制55分钟)。
9.根据权利要求4所述的制备方法,其特征在于:步骤(3)研磨成细末过90-110目筛待用(优选研磨成细末过100目筛待用)。
10.根据权利要求4所述的制备方法,其特征在于:步骤(4)一边煎煮一边搅拌13-18分钟放入白凡士林(优选一边煎煮一边搅拌15分钟放入白凡士林)。
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