CN105497627A - 具有美白皮肤功效的中药组合物 - Google Patents
具有美白皮肤功效的中药组合物 Download PDFInfo
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- CN105497627A CN105497627A CN201510996609.3A CN201510996609A CN105497627A CN 105497627 A CN105497627 A CN 105497627A CN 201510996609 A CN201510996609 A CN 201510996609A CN 105497627 A CN105497627 A CN 105497627A
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Abstract
本发明提供了一种具有美白皮肤功效的中药组合物,其原料药包括黄精、白芷、茜草、巴戟天、桑白皮、白头翁、甘草、鸡血藤、枸杞子、女贞子、白术、知母、升麻、冬凌草、大青叶、云苔草、马尾连、牛筋草、蒲黄、积雪草和白花蛇舌草。该中药组合物药性稳定、药力持久,而且对皮肤作用温和、刺激性小、安全性高、疗效显著。
Description
技术领域
本发明涉及中医药技术领域,尤其涉及一种具有美白皮肤功效的中药组合物。
背景技术
随着社会的进步,人们生活水平的提高,美容化妆品已成为生活中不可或缺的美丽元素,美白是女性护肤恒久不变的主题。一般而言,皮肤的美白主要就是外防紫外线,内抵黑色素。黑色素增多性皮肤病是由于黑素细胞和黑素生成异常造成。虽然黑色素增多性皮肤病对健康不会构成重大危害,但有碍美容,由此对患者造成精神上的压力,影响其工作、学习、生活等。常见于黄褐斑、雀斑等病。其治疗多采用激光、磨削、口服及外用药物治疗等方法。
绿色天然也已成为化妆品的主题。而天然活性化妆品顺应回归大自然的潮流和人们的消费心理,特别是添加中药有效成分的化妆品前景广阔。同时含中药有效成分的化妆品,由于其独特的药效高、副作用小、无毒的特点,越来越受到消费者的青睐。丰富的药用资源是我国中药的宝库,几千年来劳动人民积累了不少天然药物用药经验,添加了中草药提取物的化妆品是中华民族的瑰宝,其不仅药性稳定、药力持久,而且对皮肤作用温和、刺激性小、安全性高、疗效显著。
发明内容
本发明所要解决的技术问题是提供一种采用中草药成分制备而成的具有美白皮肤功效的中药组合物,其药性稳定、药力持久,而且对皮肤作用温和、刺激性小、安全性高、疗效显著。
为解决上述技术问题,本发明提供了一种具有美白皮肤功效的中药组合物,其原料药包括黄精、白芷、茜草、巴戟天、桑白皮、白头翁、甘草、鸡血藤、枸杞子、女贞子、白术、知母、升麻、冬凌草、大青叶、云苔草、马尾连、牛筋草、蒲黄、积雪草和白花蛇舌草。
其中,所述中草药提取成分中各原料药的重量分别为黄精25g~35g、白芷40g~50g、茜草25g~35g、巴戟天20g~30g、桑白皮15g~25g、白头翁20g~30g、甘草25g~35g、鸡血藤20g~30g、枸杞子30g~40g、女贞子20g~30g、白术30g~40g、知母15g~25g、升麻10g~20g、冬凌草25g~35g、大青叶25g~35g、云苔草25g~35g、马尾连15g~25g、牛筋草10g~20g、蒲黄25g~35g、积雪草25g~35g和白花蛇舌草20g~30g。
其中,所述中草药提取成分中各原料药的重量分别为黄精28g~32g、白芷43g~47g、茜草28g~32g、巴戟天23g~27g、桑白皮18g~22g、白头翁23g~27g、甘草28g~32g、鸡血藤23g~27g、枸杞子33g~37g、女贞子23g~27g、白术33g~37g、知母18g~22g、升麻13g~17g、冬凌草28g~32g、大青叶28g~32g、云苔草28g~32g、马尾连18g~22g、牛筋草13g~17g、蒲黄28g~32g、积雪草28g~32g和白花蛇舌草23g~27g。
其中,所述中草药提取成分中各原料药的重量分别为黄精30g、白芷45g、茜草30g、巴戟天25g、桑白皮20g、白头翁25g、甘草30g、鸡血藤25g、枸杞子35g、女贞子25g、白术35g、知母20g、升麻15g、冬凌草30g、大青叶30g、云苔草30g、马尾连20g、牛筋草15g、蒲黄30g、积雪草30g和白花蛇舌草25g。
本发明还提供了所述中药组合物的制备方法,其包括:
第一步,将所述中草药提取成分的各原料药分别放在高压锅蒸煮杀菌20-40分钟,晾干,获得无菌原料药;
第二步,将黄精、白芷、白头翁、甘草、鸡血藤、枸杞子、白术、知母、大青叶、云苔草、牛筋草和白花蛇舌草按上述重量送入混合机中搅拌混合均匀,获得混合物,将混合物装入渗漉筒中,每100g混合物加醇浓度为70%~80%的乙醇300ml~500ml,在25℃~35℃的条件下浸泡20小时~30小时,调节渗漉筒阀门,使乙醇浸泡液慢慢滴出,滴出速度为每分钟2~4mL,放弃前100ml,随后开始收集滴出液,收集的液滴的颜色由浓转淡,待收集的液滴无色为止,浓缩,除去乙醇溶剂,干燥,粉碎,获得第一粉末;
第三步,将余下原料药组分按上述重量送入混合机中搅拌混合均匀,获得混合物,加相对于混合物4~6倍量的水,煮沸3~5小时,过滤,滤渣再次加入相对于混合物1~2倍量的水,煮沸2~4小时,过滤,合并滤液,减压浓缩除去水,干燥,粉碎,获得第二粉末;
第四步,将第一粉末和第二粉末混合,采用超微粉碎机进一步粉碎,粉碎成200目的粉末。
本发明的有益效果:
本发明提供一种具有美白皮肤功效的中药组合物,其药性稳定、药力持久,而且对皮肤作用温和、刺激性小、安全性高、疗效显著。
具体实施方式
本发明提供了一种具有美白皮肤功效的中药药膏,其包括中草药提取成分和药膏基质,所述中草药提取成分与药膏基质的质量比为1:2~1:4。
所述中草药提取成分的原料药包括黄精、白芷、茜草、巴戟天、桑白皮、白头翁、甘草、鸡血藤、枸杞子、女贞子、白术、知母、升麻、冬凌草、大青叶、云苔草、马尾连、牛筋草、蒲黄、积雪草和白花蛇舌草。
进一步优选,所述中草药提取成分仅由上述原料药制备而成。
所述中草药提取成分中各原料药的重量分别为黄精25g~35g、白芷40g~50g、茜草25g~35g、巴戟天20g~30g、桑白皮15g~25g、白头翁20g~30g、甘草25g~35g、鸡血藤20g~30g、枸杞子30g~40g、女贞子20g~30g、白术30g~40g、知母15g~25g、升麻10g~20g、冬凌草25g~35g、大青叶25g~35g、云苔草25g~35g、马尾连15g~25g、牛筋草10g~20g、蒲黄25g~35g、积雪草25g~35g和白花蛇舌草20g~30g。
进一步优选,所述中草药提取成分中各原料药的重量分别为黄精28g~32g、白芷43g~47g、茜草28g~32g、巴戟天23g~27g、桑白皮18g~22g、白头翁23g~27g、甘草28g~32g、鸡血藤23g~27g、枸杞子33g~37g、女贞子23g~27g、白术33g~37g、知母18g~22g、升麻13g~17g、冬凌草28g~32g、大青叶28g~32g、云苔草28g~32g、马尾连18g~22g、牛筋草13g~17g、蒲黄28g~32g、积雪草28g~32g和白花蛇舌草23g~27g。
最优选,所述中草药提取成分中各原料药的重量分别为黄精30g、白芷45g、茜草30g、巴戟天25g、桑白皮20g、白头翁25g、甘草30g、鸡血藤25g、枸杞子35g、女贞子25g、白术35g、知母20g、升麻15g、冬凌草30g、大青叶30g、云苔草30g、马尾连20g、牛筋草15g、蒲黄30g、积雪草30g和白花蛇舌草25g。
所述中草药提取成分的制备方法具体为:
第一步,将所述中草药提取成分的各原料药分别放在高压锅蒸煮杀菌20-40分钟,晾干,获得无菌原料药;
第二步,将黄精、白芷、白头翁、甘草、鸡血藤、枸杞子、白术、知母、大青叶、云苔草、牛筋草和白花蛇舌草按上述重量送入混合机中搅拌混合均匀,获得混合物,将混合物装入渗漉筒中,每100g混合物加醇浓度为70%~80%的乙醇300ml~500ml,在25℃~35℃的条件下浸泡20小时~30小时,调节渗漉筒阀门,使乙醇浸泡液慢慢滴出,滴出速度为每分钟2~4mL,放弃前100ml,随后开始收集滴出液,收集的液滴的颜色由浓转淡,待收集的液滴无色为止,浓缩,除去乙醇溶剂,干燥,粉碎,获得第一粉末;
第三步,将余下原料药组分按上述重量送入混合机中搅拌混合均匀,获得混合物,加相对于混合物4~6倍量的水,煮沸3~5小时,过滤,滤渣再次加入相对于混合物1~2倍量的水,煮沸2~4小时,过滤,合并滤液,减压浓缩除去水,干燥,粉碎,获得第二粉末;
第四步,将第一粉末和第二粉末混合,采用超微粉碎机进一步粉碎,粉碎成200目的粉末。
所述中药药膏的基质的原料包括蜂蜜、茶油、芝麻油和凡士林。
进一步,所述基质仅由上述原料构成。
所述基质中各原料的重量分别为蜂蜜80~100g、茶油90~110g、芝麻油50~70g和凡士林150~170g。
进一步,所述基质中各原料的重量分别为蜂蜜90g、茶油100g、芝麻油60g和凡士林160g。
所述基质的制备方法具体为按上述重量称取蜂蜜、茶油、芝麻油和凡士林,分别置入加热装置中,搅拌,加热至100~120℃,20~40分钟后,用多层消毒纱布,乘热过滤到配料桶中,搅拌均匀,获得基质。
本发明还提供了上述中药药膏的制备方法,其包括:
第一步,按照上述方法制备中草药提取成分;
第二步,按照上述方法制备基质;
第三步,将第一步制备的中草药提取成分加入温度在40~50℃之间的基质中,不断觉拌均匀,直至冷却至常温,获得药膏;承载膏体的容器消毒后,将上述冷后的药膏装载入承载膏体的容器中。
黄精:味甘,性平,入肺、脾、肾经,具有养气养阴,健脾润肺,益肾填精的功效,用于脾胃气阴亏虚,食少无力,阴虚肺燥,干咳少痰,阴虚内热之消渴,肾虚精亏、阳痿遗精、头晕耳鸣、目昏眼花等证。
白芷:性温,味辛,归肺、脾、胃经,具有解表散寒,祛风止痛,通鼻窍,燥湿止带,消肿排脓的功效,主治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥痒,疥癣等证。
茜草:性寒,味苦,归肝经,功效:凉血止血;活血化瘀,主治血热咯血、吐血、衄血、尿血、便血、崩漏、经闭、产后瘀阻腹痛、跌打损伤、风湿痹痛、黄疸、疮痈、痔肿等证。
巴戟天:拉丁名MorindaeOfficinalisRadix,味辛、甘,性微温,入肝、肾经,具有补肾阳、强筋骨、祛风湿的功效,用于肾虚阳痿、遗精早泄、少腹冷痛,宫冷不孕,肝肾不足所致的筋骨痿软、腰膝冷痛等证。
桑白皮:拉丁名MoriCortex,味甘,性寒,入肺经,具有泻肺平喘,利水消肿的功效,用于肺热咳喘,面目浮肿,小便不利等症。
白头翁:味苦,性寒,入胃、大肠经,有清热解毒、凉血止痢的作用,主要用于肠胃有湿热积滞之发热腹痛,下痢脓血,里急后重等症状的治疗,对大肠血热之热痢下血效果较好,白头翁对痢疾杆菌、伤寒杆菌、枯草杆菌、大肠杆菌、黄金色葡萄球菌均有一定的抑制作用。
甘草:味甘,性平,归十二经,有清热解毒,调和药性,祛痰止咳的作用,并能健脾和中,缓急止痛,主要用于脾胃虚弱之腹胀纳呆,乏力;能缓解腹中拘挛性疼痛,缓和某些药物的烈性和毒性,减轻药物对机体的毒副作用或对胃肠道的刺激,通过加入甘草能起到补气中和,调和各组分的作用。
鸡血藤:拉丁名spatholobicaulis,味苦、甘,性温,归肝、肾经,具有扩张血管,补血活血,调经,舒筋活络的功效,主治血虚有淤之月经不调,四肢疼痛不仁,腰膝酸软、疼痛等证。
枸杞子:拉丁名lyciifructus,味甘、性平,入肝、肾经,有补益肝肾、养血补血、益精明目、润肺止咳的作用,主要用于肝肾两虚、精血不足之腰膝酸软、头晕耳鸣、遗精耳鸣、自汗乏力;肾阳不足之阳痿、不育;阴精亏损、肝血不足之眼目昏花以及阴虚劳嗽等证
女贞子:味甘、苦,微寒,入肝、肾经,有强肝益肾,清热明目的作用,主要用于治疗肝肾阴亏,头目失养之头昏耳鸣,阴虚内热等症状。女贞子能提升白细胞,增强免疫功能的功效,对金黄色葡萄球菌、痢疾杆菌有较强的抑制作用。
白术:拉丁名atractylodismacrocephalaerhizoma,味苦、甘,性温,入脾、胃经,具有健脾益气,燥湿利水,止汗,安胎的作用,用于脾胃虚弱,食少胀满,倦怠乏力,泄泻,水湿停留、痰饮、水肿,表虚自汗等证。
知母:味苦、甘,性寒,归肺、胃、肾经,具有清热泻火、生津润燥的功效,主治热病壮热烦渴,肺热咳嗽,咽喉肿痛,骨蒸潮热,虚烦不眠,消渴淋浊,大便秘结等证。
升麻:味辛、微甘,性微寒,入肺、脾、胃、大肠经,具有发表透疹,清热解毒,升举阳气的功效。用于风热头痛,齿痛,口疮,咽喉肿痛,麻疹不透,阳毒发斑;脱肛,子宫脱垂等证。
冬凌草:味苦、甘,性微寒,归肺、胃、肝经,具有清热解毒,活血止痛的功效,主治咽喉肿痛、扁桃体炎、感冒头痛、气管炎、慢性肝炎、关节风湿痛、蛇虫咬伤等证。
大青叶:拉丁名IsatidisFolium,味苦、性大寒,归心、肝、胆、胃经,有清瘟解毒,凉血化斑,退黄的功效,既能清气分之实热,又能解血分之热毒,主要用于瘟病热病所致之高热汗出,烦渴引饮;火毒炽盛之发斑发狂,吐血等症状;麻疹之高热神昏,疹色紫暗;肝胆湿热蕴蒸之黄疸;肝胆火升之耳聋耳鸣;火郁热毒所致之咽痛、口舌生疮、肝炎等证。
云苔草:为报春花科报春花属植物无粉报春的根或全草,味苦、辛,性平,具有祛风除湿,解毒消肿的功效,主治感冒发热,咳嗽,咽喉肿痛,牙痛,风湿痹痛,肝炎,痢疾,淋证,皮肤瘙痒,毒蛇咬伤等证。
马尾连:为毛莨科唐松草属植物金丝马尾连、昭通唐松草、高原唐松草、多叶唐松草的根及根茎,味苦,性寒,归心、肝、大肠经,具有清热燥湿,泻火解毒的功效,主治湿热泄泻,痢疾,黄疸,感冒发热,麻疹,目赤肿痛等证。
牛筋草:为禾本科蟋蟀草属植物牛筋草的根或全草,味甘、淡,性凉,具有清热解毒,利湿,凉血散瘀的功效,主治伤暑发热,小儿惊风,乙脑,流脑,黄疸,淋证,小便不利,痢疾,便血,荨麻疹,跌打损伤等证。
蒲黄:味甘,性平,入肝、心包经,具有止血,化瘀,通淋的功效。用于吐血,衄血,咯血,崩漏,外伤出血,经闭痛经,脘腹刺痛,跌扑肿痛,血淋涩痛,蒲黄对心血管系统有调节作用,能增加冠状动脉流量,改善微循环和心肌缺血状况,有效降低血脂作用。
积雪草:味苦,辛,性凉,归肝,胆,膀胱经,具有利湿通淋,清热解毒,散瘀消肿的功效,主治湿热黄疸,中暑腹泻,石淋血淋,痈肿疮毒,跌扑损伤等证。
白花蛇舌草:味苦、甘,性寒,入心,肝,脾,大肠经,具有清热解毒,利水渗湿的作用,用于肺热喘咳,咽喉肿痛,肠痈,疖肿疮疡,毒蛇咬伤,热淋涩痛,水肿,痢疾,肠炎,湿热黄疸,癌肿等证。
以下采用实施例来详细说明本发明的实施方式,借此对本发明如何应用技术手段来解决技术问题,并达成技术效果的实现过程能充分理解并据以实施。
实施例1中草药提取成分
将黄精30g、白芷45g、茜草30g、巴戟天25g、桑白皮20g、白头翁25g、甘草30g、鸡血藤25g、枸杞子35g、女贞子25g、白术35g、知母20g、升麻15g、冬凌草30g、大青叶30g、云苔草30g、马尾连20g、牛筋草15g、蒲黄30g、积雪草30g和白花蛇舌草25g分别放在高压锅蒸煮杀菌30分钟,晾干,获得无菌原料药,将黄精、白芷、白头翁、甘草、鸡血藤、枸杞子、白术、知母、大青叶、云苔草、牛筋草和白花蛇舌草按上述重量送入混合机中搅拌混合均匀,获得混合物,将混合物装入渗漉筒中,每100g混合物加醇浓度为80%的乙醇400ml,在30℃的条件下浸泡20小时,调节渗漉筒阀门,使乙醇浸泡液慢慢滴出,滴出速度为每分钟3mL,放弃前100ml,随后开始收集滴出液,收集的液滴的颜色由浓转淡,待收集的液滴无色为止,浓缩,除去乙醇溶剂,干燥,粉碎,获得第一粉末,将余下原料药组分按上述重量送入混合机中搅拌混合均匀,获得混合物,加相对于混合物5倍量的水,煮沸4小时,过滤,滤渣再次加入相对于混合物2倍量的水,煮沸3小时,过滤,合并滤液,减压浓缩除去水,干燥,粉碎,获得第二粉末,将第一粉末和第二粉末混合,采用超微粉碎机进一步粉碎,粉碎成200目的粉末。
急性毒性实验
将小鼠随机分为试验组和空白对照组,各20只。试验前禁食(不禁水)12h后,将实施例1制备的中草药提取成分1溶解在水中配置成4g(生药)/ml的溶液,供试验组每天1次灌胃给药,空白对照组灌给等量生理盐水。连续14d,记录受试小鼠行为、活动、摄食量、体重、粪便、死亡等情况,未死亡小鼠于14d后处死进行尸检。
药物试验组40g(生药)/kg剂量给药的小鼠,当天见小鼠毛色光滑、粪便为褐色,质地较稀软,摄食、活动较少,第2天后小鼠活动、摄食量、体重增长、粪便等均恢复正常,与空白对照组比较无明显差异;且14d内无死亡及其他异常发生,两组同时处死后进行尸检,各主要脏器(心、肝、脾、肺、肾)经肉眼观察未见异常。
长期毒性实验
将大鼠随机分为试验组和空白对照组,各20只。将实施例1制备的中草药提取成分1溶解在水中配置成4g(生药)/ml的溶液,供试验组每天1次灌胃给药,反复给药的时间为5周,试验组剂量为10g(生药)/kg。试验动物在整个试验期内行为活动、饮食、大小便和被毛色泽等情况未见明显异常,未见呕吐、流涎、流泪、呼吸困难等症状。
大鼠主要脏器的解部学观察:试验结束后处死动物,立即解剖,肉眼观察大脑、心脏、肝脏、脾脏、肺脏、肾脏等主要器官,各器官表面光滑,无粘连,色泽正常,未见充血、肿胀、出血、坏死、粘连,胃肠无扩张,肠壁无水肿、出血、溃疡等异常现象。
病理组织学检查结果
心脏:心肌细胞横纹清晰,核居中,间质未见血管扩张及炎细胞浸润;心外膜、心内膜无异常。肝脏:肝细胞排列呈索状,肝小叶结构清楚,汇管区未见炎细胞浸润及纤维结缔组织增生,肝细胞多边形,浆丰富,核大而圆。脾脏:纤维包膜完整,无增厚,脾小体清晰可见,小梁结构正常,红髓、白髓清楚,未见变性、坏死及炎细胞浸润。肺脏:细支气管结构完整,层次清楚,肺泡壁结构完整,肺间隔及支气管完好无损,腔内无明显渗出物,未见变性、坏死及炎细胞浸润。肾脏:肾脏皮质、髓质、肾小球结构正常,肾小球细胞数未增多,毛细血管管腔无扩张,肾小管上皮细胞、肾间质未见异常。大脑:组织结构正常,神经细胞、神经胶质细胞形态正常,各层神经元细胞无明显异常。
实施例2中草药提取成分
将黄精28g、白芷43g、茜草28g、巴戟天23g、桑白皮18g、白头翁23g、甘草28g、鸡血藤23g、枸杞子33g、女贞子23g、白术33g、知母18g、升麻13g、冬凌草28g、大青叶28g、云苔草28g、马尾连18g、牛筋草13g、蒲黄28g、积雪草28g和白花蛇舌草23g分别放在高压锅蒸煮杀菌30分钟,晾干,获得无菌原料药,将黄精、白芷、白头翁、甘草、鸡血藤、枸杞子、白术、知母、大青叶、云苔草、牛筋草和白花蛇舌草按上述重量送入混合机中搅拌混合均匀,获得混合物,将混合物装入渗漉筒中,每100g混合物加醇浓度为80%的乙醇400ml,在30℃的条件下浸泡20小时,调节渗漉筒阀门,使乙醇浸泡液慢慢滴出,滴出速度为每分钟3mL,放弃前100ml,随后开始收集滴出液,收集的液滴的颜色由浓转淡,待收集的液滴无色为止,浓缩,除去乙醇溶剂,干燥,粉碎,获得第一粉末,将余下原料药组分按上述重量送入混合机中搅拌混合均匀,获得混合物,加相对于混合物5倍量的水,煮沸4小时,过滤,滤渣再次加入相对于混合物2倍量的水,煮沸3小时,过滤,合并滤液,减压浓缩除去水,干燥,粉碎,获得第二粉末,将第一粉末和第二粉末混合,采用超微粉碎机进一步粉碎,粉碎成200目的粉末。
实施例3中草药提取成分
将黄精32g、白芷47g、茜草32g、巴戟天27g、桑白皮22g、白头翁27g、甘草32g、鸡血藤27g、枸杞子37g、女贞子27g、白术37g、知母22g、升麻17g、冬凌草32g、大青叶32g、云苔草32g、马尾连22g、牛筋草17g、蒲黄32g、积雪草32g和白花蛇舌草27g分别放在高压锅蒸煮杀菌30分钟,晾干,获得无菌原料药,将黄精、白芷、白头翁、甘草、鸡血藤、枸杞子、白术、知母、大青叶、云苔草、牛筋草和白花蛇舌草按上述重量送入混合机中搅拌混合均匀,获得混合物,将混合物装入渗漉筒中,每100g混合物加醇浓度为80%的乙醇400ml,在30℃的条件下浸泡20小时,调节渗漉筒阀门,使乙醇浸泡液慢慢滴出,滴出速度为每分钟3mL,放弃前100ml,随后开始收集滴出液,收集的液滴的颜色由浓转淡,待收集的液滴无色为止,浓缩,除去乙醇溶剂,干燥,粉碎,获得第一粉末,将余下原料药组分按上述重量送入混合机中搅拌混合均匀,获得混合物,加相对于混合物5倍量的水,煮沸4小时,过滤,滤渣再次加入相对于混合物2倍量的水,煮沸3小时,过滤,合并滤液,减压浓缩除去水,干燥,粉碎,获得第二粉末,将第一粉末和第二粉末混合,采用超微粉碎机进一步粉碎,粉碎成200目的粉末。
实施例4药膏基质
称取蜂蜜90g、茶油100g、芝麻油60g和凡士林160g,分别置入加热装置中,搅拌,加热至120℃,30分钟后,用多层消毒纱布,乘热过滤到配料桶中,搅拌均匀,获得基质。
实施例5中药药膏
将300g实施例1制备的中草药提取成分粉末加入温度在45℃的基质700g中,不断觉拌均匀,直至冷却至常温,获得药膏;承载膏体的容器消毒后,将上述冷后的药膏装载入承载膏体的容器中。
皮肤刺激性试验
用健康成年白色家免4只,体重2.5~2.7kg,雌雄各半。将其脊柱两侧皮肤去毛3cm×3cm,将实施例5制备的药膏1涂抹在2.5cm×2.5cm二层纱布上,随后敷贴于家兔背部一侧去毛的皮肤上,用一层玻璃纸覆盖,再用无刺激性医用胶布和绷带加以固定,另一侧用蒸馏水作对照。每只试验动物敷贴4h后,去除受试物,用温水清洗敷贴部位的皮肤,分别于1、24、48h观察并记录敷贴部位的皮肤反应,按照《消毒技术规范》规定的评分标准及分级进行评分。皮肤刺激性试验表明,本发明提供的中药药膏对家兔皮肤刺激反应积分为0,皮肤无红斑,属无刺激。
实施例6动物实验
材料
小鼠B16黑色素瘤细胞株、DMEM培养基购于北京中医药大学。胰酶、四甲基偶氮唑蓝(MTT)购于Sigma公司,CO2培养箱,日本SANYO公司。
酶标仪,美国BIO-RAD公司;分光光度计,日本HITACHI公司。
药物
本发明实施例1制备的中草药提取成分。
小鼠B16黑色素细胞培养
无菌条件下,将1×105个/mL的小鼠B16黑色素细胞接种于含10%(体积分数)小牛血清的DMEM培养基的培养瓶中,在37℃、5%CO2培养箱中培养,每3天用0.25%胰酶消化传代一次。
细胞增殖率的测定
待细胞生长到对数期,用0.25%胰酶消化,调整到细胞2×104个/mL,接种于96孔板中,每孔100μL。置于培养箱中培养24h后,弃上清液,添加待测的中草药提取成分。每一浓度设8个孔,共设三个浓度,分别为0.01mg/ml、0.1mg/ml和1mg/ml,对照组不加药物,代之同量维持液。孵育72h。
药物作用72h后,每孔加入5g/LMTT溶液10μL,4h后弃上清液,每孔加入DMSO100μL,振荡10min左右,在酶标仪上检测各孔吸光度值,波长为490nm。
细胞增殖率=药物组平均吸光度值/对照组平均吸光度值×100%。
统计学方法
采用SPSS11.0系统软件处理数据,计量资料用(±s)表示,组间比较采用单因素方差分析,计数资料采用χ2检验,P<0.05为差异有统计学意义。
结果
不同浓度下黑色素细胞增殖情况,见表1。
表1不同浓度下黑色素细胞增殖情况
0.01mg/ml | 0.1mg/ml | 1mg/ml | |
中草药提取成分 | 83.6+5.9 | 43.7+3.9 | 21.7+5.5 |
皮肤的颜色主要取决于皮肤里所含黑色素细胞的多少,与对照组相比,随着中草药提取成分的添加,可以显著降低黑色素细胞的增殖情况,因此,采用本发明提供的中药药膏可以很好的起到美白的效果。
实施例7人体实验
仪器
美能达CR-10型色差仪(日本柯尼卡美能达公司)。
产品
本发明实施例5制备的中药药膏。
人体试验受试对象及分组
选择自愿受试人190例,年龄18—24岁,皮肤健康,无化妆品过敏史,分为两组,第一组采用本发明实施例5提供的中药药膏,第二组不采用任何护肤品。
受试涂抹方法
受试者左、右前臂臂弯处,连续测试6次,取平均值(先测右臂再测左臂);使用化妆品前1d,以及使用1周、2周、3周、4周后。
测试指标
采用色差仪测定左右臂色差ΔL。ΔL为正值,表示左臂较右臂偏白,ΔL为负值,表示左臂较右臂偏黑。
统计学方法
采用SPSS11.0系统软件处理数据,计量资料用(±s)表示,组间比较采用单因素方差分析,计数资料采用χ2检验,P<0.05为差异有统计学意义。
结果
使用后与使用前相比各组的ΔL值变化,结果见表2。
表2使用后与使用前相比各组的ΔL值变化
1周后 | 2周后 | 3周后 | 4周后 | |
第一组 | 0.72+0.13 | 1.36+0.20 | 1.77+0.26 | 2.01+0.19 |
第二组 | 0.01+0.01 | 0.05+0.02 | 0.06+0.02 | 0.05+0.03 |
在Lab色度系统中,Lab色度系统表明了颜色在色空间的位置,并加以量化,使颜色变化以数值的形式表达,肉眼不能看见的细微变化也可反映出来。在使用的过程中,第一组的ΔL明显发生了变化,随着使用时间的增加,ΔL值均发生差异性变大。表明配制的中药药膏均有美白效果,并随着使用时间的增加美白效果越明显。
所有上述的首要实施这一知识产权,并没有设定限制其他形式的实施这种新产品和/或新方法。本领域技术人员将利用这一重要信息,上述内容修改,以实现类似的执行情况。但是,所有修改或改造基于本发明新产品属于保留的权利。
以上所述,仅是本发明的较佳实施例而已,并非是对本发明作其它形式的限制,任何熟悉本专业的技术人员可能利用上述揭示的技术内容加以变更或改型为等同变化的等效实施例。但是凡是未脱离本发明技术方案内容,依据本发明的技术实质对以上实施例所作的任何简单修改、等同变化与改型,仍属于本发明技术方案的保护范围。
Claims (5)
1.一种具有美白皮肤功效的中药组合物,其特征在于:原料药包括黄精、白芷、茜草、巴戟天、桑白皮、白头翁、甘草、鸡血藤、枸杞子、女贞子、白术、知母、升麻、冬凌草、大青叶、云苔草、马尾连、牛筋草、蒲黄、积雪草和白花蛇舌草。
2.如权利要求1所述的中药组合物,其特征在于:各原料药的重量分别为黄精25g~35g、白芷40g~50g、茜草25g~35g、巴戟天20g~30g、桑白皮15g~25g、白头翁20g~30g、甘草25g~35g、鸡血藤20g~30g、枸杞子30g~40g、女贞子20g~30g、白术30g~40g、知母15g~25g、升麻10g~20g、冬凌草25g~35g、大青叶25g~35g、云苔草25g~35g、马尾连15g~25g、牛筋草10g~20g、蒲黄25g~35g、积雪草25g~35g和白花蛇舌草20g~30g。
3.如权利要求1或2所述的中药组合物,其特征在于:各原料药的重量分别为黄精28g~32g、白芷43g~47g、茜草28g~32g、巴戟天23g~27g、桑白皮18g~22g、白头翁23g~27g、甘草28g~32g、鸡血藤23g~27g、枸杞子33g~37g、女贞子23g~27g、白术33g~37g、知母18g~22g、升麻13g~17g、冬凌草28g~32g、大青叶28g~32g、云苔草28g~32g、马尾连18g~22g、牛筋草13g~17g、蒲黄28g~32g、积雪草28g~32g和白花蛇舌草23g~27g。
4.如权利要求1至3所述的中药组合物,其特征在于:各原料药的重量分别为黄精30g、白芷45g、茜草30g、巴戟天25g、桑白皮20g、白头翁25g、甘草30g、鸡血藤25g、枸杞子35g、女贞子25g、白术35g、知母20g、升麻15g、冬凌草30g、大青叶30g、云苔草30g、马尾连20g、牛筋草15g、蒲黄30g、积雪草30g和白花蛇舌草25g。
5.权利要求1至4所述中药组合物的制备方法,其特征在于,包括:
第一步,将所述中草药提取成分的各原料药分别放在高压锅蒸煮杀菌20-40分钟,晾干,获得无菌原料药;
第二步,将黄精、白芷、白头翁、甘草、鸡血藤、枸杞子、白术、知母、大青叶、云苔草、牛筋草和白花蛇舌草按上述重量送入混合机中搅拌混合均匀,获得混合物,将混合物装入渗漉筒中,每100g混合物加醇浓度为70%~80%的乙醇300ml~500ml,在25℃~35℃的条件下浸泡20小时~30小时,调节渗漉筒阀门,使乙醇浸泡液慢慢滴出,滴出速度为每分钟2~4mL,放弃前100ml,随后开始收集滴出液,收集的液滴的颜色由浓转淡,待收集的液滴无色为止,浓缩,除去乙醇溶剂,干燥,粉碎,获得第一粉末;
第三步,将余下原料药组分按上述重量送入混合机中搅拌混合均匀,获得混合物,加相对于混合物4~6倍量的水,煮沸3~5小时,过滤,滤渣再次加入相对于混合物1~2倍量的水,煮沸2~4小时,过滤,合并滤液,减压浓缩除去水,干燥,粉碎,获得第二粉末;
第四步,将第一粉末和第二粉末混合,采用超微粉碎机进一步粉碎,粉碎成200目的粉末。
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