CN105496853A - Skin-whitening cosmetic containing rhodiola rosea extract, polygonum multiflorum extract and salvia miltiorrhiza extract - Google Patents
Skin-whitening cosmetic containing rhodiola rosea extract, polygonum multiflorum extract and salvia miltiorrhiza extract Download PDFInfo
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- CN105496853A CN105496853A CN201510962281.3A CN201510962281A CN105496853A CN 105496853 A CN105496853 A CN 105496853A CN 201510962281 A CN201510962281 A CN 201510962281A CN 105496853 A CN105496853 A CN 105496853A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The invention relates to a skin-whitening cosmetic containing a rhodiola rosea extract, a polygonum multiflorum extract and a salvia miltiorrhiza extract. The skin-whitening cosmetic is prepared from, by weight, 20-30 parts of squalane, 4-6 parts of paraffin, 1-3 parts of corn oil extract, 4-6 parts of 1,3-propanediol, 0.5-1.5 parts of guar gum, 4-6 parts of PEG-40 hydrogenated castor oil, 0.05-0.1 part of the rhodiola rosea extract, 0.05-0.1 part of a fleece-flower root extract and 0.05-0.1 part of the salvia miltiorrhiza extract. The skin-whitening cosmetic has the advantages that the skin-whitening cosmetic is reasonable in formula, the raw materials are natural and free of toxic and harmful effects, and the effect is remarkable. The skin-whitening cosmetic is suitable for any age group of populations to use.
Description
Technical field
The present invention relates to cosmetic formulations technical field, particularly a kind of skin-lightening cosmetic containing Radix Rhodiolae extract, Radix Polygoni Multiflori extract and Radix Salviae Miltiorrhizae extract.
Background technology
Occur that chromogenesis is lacked of proper care along with on the aging of population, environmental pollution, the increasing people's skin of global warning in recent years, the brown patch of skin, freckle have become serious skin puzzlement.Black pigment calmness particularly after brown patch, freckle and Exposure to Sunlight on skin can produce with age increase, increase, and is more and more difficult to eliminate simultaneously, thus becomes the unavoidable worry of people.Black pigment calm on skin is almost melanin entirely, and produce in the melanosome in its melanocyte between epidermis and corium, the melanocyte of generation is spread to flanking cell by osmosis.
At present, all toxic heavy metal hydrargyrum in a lot of cosmetics, some cosmetics is also containing arsenic.These materials all have high toxicity.Lead in cosmetics, arsenic, mercury content exceed standard, and work the mischief to health.Mercuric chloride in cosmetics brightening agent, mercuric iodixde can disturb the melanic normal enzyme of amino acids in skin to transform.The chronic murder by poisoning of hydrargyrum is very large, particularly suppresses the formation of sexual cell, affects youthful fertility.Specify in some national cosmetic quality, must not adapted mercury and mercuric compounds in cosmetics.Mostly containing heavy metal Hg, lead, arsenic in hair growth promoter, hair dye, they are all extremely harmful to human body.
Employ a lot of pigments, antiseptic, spice etc. in a lot of cosmetics, they are also organic synthesis thing mostly.As coal tar oils synthetic perfume, aldehydes series synthetic perfume etc.These materials have stimulation to skin, cause Skin pigmentation, and cause contact dermatitis.Spice in cosmetics, widely uses coal tar oils synthetic perfume, in coal tar system pigment, has azo dye, nitroso-dyes and nitro pigment etc., containing genotoxic potential, causes cosmetics to increase the hazardness of human body.In synthetic perfume, picture aldehydes series of products, often very large to skin irritation.Some pigments can produce variation to cell.
Summary of the invention
For problems of the prior art, the object of the present invention is to provide the skin-lightening cosmetic containing Radix Rhodiolae extract, Radix Polygoni Multiflori extract and Radix Salviae Miltiorrhizae extract of a kind of reasonable recipe, composition Nantural non-toxic evil effect.
Technical scheme of the present invention is:
A skin-lightening cosmetic containing Radix Rhodiolae extract, Radix Polygoni Multiflori extract and Radix Salviae Miltiorrhizae extract, is made up of according to parts by weight following component:
Squalane 20-30 part; Paraffin 4-6 part; Semen Maydis oil extract 1-3 part; 1,3-PD 4-6 part; Guar gum 0.5-1.5 part; Cremophor RH40 4-6 part; Radix Rhodiolae extract 0.05-0.1 part; Radix Polygoni Multiflori extract 0.05-0.1 part; Radix Salviae Miltiorrhizae extract 0.05-0.1 part.
On the basis of such scheme, a kind of skin-lightening cosmetic containing Radix Rhodiolae extract, Radix Polygoni Multiflori extract and Radix Salviae Miltiorrhizae extract, is made up of according to parts by weight following component:
Squalane 25 parts; 5 parts, paraffin; Semen Maydis oil extract 2 parts; 1,3-PD 5 parts; Guar gum 1 part; Cremophor RH40 5 parts; Radix Rhodiolae extract 0.08 part; Radix Polygoni Multiflori extract 0.08 part; Radix Salviae Miltiorrhizae extract 0.08 part.
Radix Rhodiolae extract:
Radix Rhodiolae be once used to China, Siberia and Ukraine Carpathians Mountain area traditional herbal medicines in.Radix Rhodiolae extract derives from the root of Radix Rhodiolae, its Main Ingredients and Appearance is rhodioside and Radix Rhodiolae aglycon, there is slow down aging, whitening radioprotective, moistening skin and eliminating spot, improve cardiovascular and cerebrovascular vessel, nervous system regulation, anti-heart and brain anoxia, allaying tiredness, regain one's strength, enhancing immunity, hemopoietic function etc.
[pharmacological action] Radix Rhodiolae is mainly containing phenyl propyl and flavonoid class.Its unique activity chemical composition is phenyl propyl, rosavin (activity is the strongest), rosin, rosarin, rhodiolin, and rhodioloside and its glycoside unit, namely to butyl alcohol.Only Rhodiola rosea L. contains rosavin, rosin and rosarin.
Strengthen immunologic function: rosavins by two pathway stimulation immune systems: one, by direct specific stimulation to immune defence (one of most important type in immune stimulatory cell: natural killer cell (Naturalkillercells).NK-cell is searched for and is destroyed the infected cell of body).Radix Rhodiolae extract makes immune system recover normal by improving T-cellular immunization.This shows it can promote body to infecting the resistivity developing the poison be accumulated into gradually.Two, body is made not easily to be stressed impact.When we are exposed under pressure for a long time, and constantly capture energy to other system, total impact be exactly that immunoreation reduces and healthy to be deteriorated.Radix Rhodiolae extract also by preventing the suppression come because of pressure and fatigue to B cell immunity, thus strengthens B cell immunity.
Antibacterial action: containing volume scopolamine, kaempferol etc., there is anti-inflammation composition in Radix Rhodiolae; Content of tannin is also maximum, and Bearberry Extract, shields at mucomembranous surface, and prevent too much secretion, stop excessive hemorrhage, the cough caused pneumonia, expectoration and women's leucorrhoea grow in quantity are effective in cure.
Protection cardiovascular function: Radix Rhodiolae extract display can relax due to pressure cardiovascular tissue damage and dysfunction.Radix Rhodiolae extract can prevent from declining because of the cardiac contractile force of ambient pressure secondary under urgency freezes state and contributing to stabilized contraction.Utilize Radix Rhodiolae pretreatment it seems can to cause the useful adaptation response to the type pressure.When taking the mice after Radix Rhodiolae and being exposed to anxious freezing under state, the decline of cardiac contractile force is prevented from, and the stabilized contraction of heart tissue continues to occur between flush phase always.
The use that other report proposes Radix Rhodiolae extract can be protected the cardiovascular organization of rat under the release of due to pressure catecholamine and alleviate arrhythmia caused by epinephrine.The anti-arrhythmia effect of Radix Rhodiolae extract is considered to the secondary effect of its induction Opium peptide biosynthesis ability and relates to exciting of peripheral cards handkerchief opiate receptors.Radix Rhodiolae extract also demonstrates the curative effect of the cardiac problems to due to pressure or deterioration.Build in its ability reducing the catecholamine that discharges because of pressure of adrenal gland and steroid total amount to the effect of these situations.The hormonal abnormal secretion of these pressure can cause blood pressure, cholesterol, the rising of potassium level and the dangerous inducement of increase heart disease.Radix Rhodiolae was once found to reduce harmful blood fat and therefore reduced trouble heart disease risk.It also reduces circulation A MP (c-AMP) total amount being released into heart cell equally.Circulation A MP is relevant with ATP (adenosine triphosphate) this human body main energy supply molecule.C-AMP is as the contact material of ' second message,second messenger ' or intraor extracellular environment.It contributes to intracellular Ca2+ and flows into heart thus the potential energy of significant increase heart muscle contraction.Therefore Radix Rhodiolae regulates heartbeat to stop arrhythmia.
Effective antioxidant: it can improve rapidly the binding ability of hemoglobin and oxygen, improves blood oxygen saturation, reduces the oxygen consumption of body, increases exercise tolerance, recovers Fatique after Sports.And by the detrimental effect that restraint of liberty base injures, it effectively can be resisted and cause disease because of old and feeble.[experiment] chooses male white mouse (about body weight 20g), and with 0.4mg/g body weight lumbar injection after training, contrast normal saline group, the record pole-climbing time, result shows significant difference.Observe white mice Loaned swimming test, result shows that medication group is better than matched group.
Promote bodily fuctions: resemble Siberian ginseng, Radix Rhodiolae extract normal passive movement person take to promote bodily fuctions.Although its mechanism is understood fully not yet completely, it seems can improve muscle/fat ratio and promote hematochrome and erythrocyte level in blood.
Active anticancer: take Radix Rhodiolae extract demonstrate as cancer therapy drug potential may, and may can be very effective when being used in conjunction with several antitumor drug.Transplant the mice of solidification Ai He Ritchie adenocarcinoma and transfer mice Puli Si lymphosarcoma, inhibit the growth of all kinds tumor when supplementing Radix Rhodiolae extract, reduce and be transferred to liver and extend the time-to-live.Take the growth and transfer scope that directly can also suppress Lewis's malignant tumor of lung of transplanting.When Radix Rhodiolae extract and antitumor drug cyclophosphamide combined being used in the identical tumor model for the treatment of, effectively improve antitumor and metastasis effect of medicine.This cancer direct cause of the existence and cell mutation of free radical is relevant.In addition, Soviet scientists finds that oral Radix Rhodiolae inhibits the experimental rat tumor of 39% to increase and reduce the transfer of the rat of 50%.It can improve urological tissue and the immunity of bladder cancer patients.To other various cancer, comprise in the experiment of adenocarcinoma (gland tissue cancer is as breast carcinoma) and malignant tumor of lung.Radix Rhodiolae extract all result in the obvious rising of survival ratio.
Improving function: in Russia and Far East culture, is used for enhancing ability and has very long history by Radix Rhodiolae extract.One comprise 35 weak by erecing, the male of premature ejaculation or both puzzlements, utilize 100-150mg Radix Rhodiolae extract continued treatment 3 months open clinical experiment in, admit that its sexual function obtains substantial improvement for 26 in 35 patients.
Promote memory: in the controlled placebo of Radix Rhodiolae extract to the effect of intelligence performance being tested at one, employ 120 people and carry out a check and correction experiment.Testee was all tested before and after taking Radix Rhodiolae extract or placebo.The record of test group obtains significantly improvement and controlled group does not change.The member of two groups constantly tested the ability that it completes check test in 24 hours that take extract or placebo.The wrongly written character number of controlled group in check test rises greatly and to have taken the function reduction scope of the group of Radix Rhodiolae extract just much smaller.
Analgesic activity: experiment adopts mice to tremble cage method, gets mice adjustable shelf and lever, starts note stricture of vagina drum soon, to trace mice activity.Lumbar injection rhodioside (400mg/kg) and normal saline (matched group).Result shows that medication group has the effect (p<0.001) obviously suppressing mice mobility.
Radiation resistance: the generation obviously suppressing the radiation-induced heart and liver LPO (lipid peroxide), plays a protective role to lipid and cell membrane.
Delaying senility function: the activity significantly improving body SOD (superoxide dismutase), scavenging free radicals, LPO inhibitor.The dual regulation of Endocrine system: the secretion of two-ways regulation adrenal hormone, gonadal hormone etc.
Radix Polygoni Multiflori extract:
Radix Polygoni Multiflori is for nourishing cloudy gas in Chinese traditional medicine, and it can maintain the balance of healthy human body.The ability making hair shiny black because of it and being used widely by oral or external by as cosmetics.
[effect purposes]: in Chinese medicine, the root block of Radix Polygoni Multiflori (Polygonummultiflorum) is used as tonifying recipes and antidotal agent, is usually used in hair growth and early whitening of hair.
The effect writing Radix Polygoni Multiflori in " Radix Polygoni Multiflori biography " is: " strengthen gas, preserve youthful looks, hair color, prolongs life for long biceps, beneficial marrow." Radix Polygoni Multiflori contains the effective ingredient such as chrysophanol, emodin, chrysophanic acid, physcione, fatty oil, starch, saccharide, rhaponticin, lecithin.Its action and efficacy is embodied in hair care, defying age two aspect.
Research shows, Radix Polygoni Multiflori can slow down aging, and its vitamin E contained can prevent wrinkle regeneration.The a large amount of lipid peroxidation product of aged animal cylinder accumulation, and the reduction of adjoint superoxide dismutase activity.Experimental result shows, Radix Polygoni Multiflori obviously can reduce Aged Mice brain and hepatic tissue mda content, increase monoamine transmitter contents in brain, enhance SOD activity, obviously can also suppress the activity of monoamine oxidase-B in Aged Mice brain and hepatic tissue, thus eliminate the damage of radical pair body, the generation of slow down aging and disease.Free radical theory is thought, generation and the deposition of lipid peroxide can cause a series of senile symptom, therefore the content of lipid peroxide evaluates one of old and feeble leading indicator, the generation of Radix Polygoni Multiflori extract to mouse skin lipid peroxide has obviously inhibitory action, illustrate that Radix Polygoni Multiflori has the effect of delay skin aging, can as good skin anti-aging cosmetics additive.In addition, Radix Polygoni Multiflori can also significantly improve the periphery lymphocyte DNA damage repair ability of senile rat, by suppressing monoamine oxidase-B in brain active, affects the content of organism central neurotransmitter, thus regulates neural activity, delay the aging of brain.
[pharmacological action]: outside anti-aging effects, Radix Polygoni Multiflori extract also has following effect:
On immune impact
The mouse thymus atrophy that Radix Polygoni Multiflori Preparata energy antagonism immunosuppressant hydrocortisone or meticortelone cause and degeneration, increase the weight of its thymus, adrenal gland, spleen and lymphonodi coeliaci, improve total white blood cells, promote the phagocytic function of peritoneal macrophage, reduce the content of mice circulating immune complex.Immunology is thought, the decline of immunologic function and the aging closely related of body, and thymus is immune maincenter organ, effectively can maintain the immunologic function of body.Radix Polygoni Multiflori can postpone the involution of thymus occurred with aging, may be its slow down aging, the important mechanisms improving immunity of organisms.In addition, Radix Polygoni Multiflori can also increase thymonucleic acid and protein content, delays senile rat thymus Age-related degeneration, and can promote that aged mouse thymus ultrastructure obviously reverses change, make Turnover of Mouse Peritoneal Macrophages phagocytic index obviously increase, thus improve the non-specific immunity of body.
Neuroprotective
Principle active component in Radix Polygoni Multiflori: stilbene glucoside causes Neuronal Survival rate to amyloid-beta and hydrogen peroxide and to decline and lactic acid dehydrogenase spills to increase and has obvious antagonism.And increase with dosage, its neuroprotective strengthens.The control of prompting stilbene glucoside to nervous system degenerative diseases such as alzheimer disease has certain effect. and Radix Polygoni Multiflori Preparata extract can suppress interleukin and nitric oxide production generation in concentration dependent ground, thus plays neuroprotective.
Antibacterial action
Radix Polygoni Multiflori different processed product decocting liquid all has inhibitory action in various degree to staphylococcus aureus, Staphylococcus albus, shigella flexneri, sonne bacillus, Bacillus typhi 901, Salmonella paratyphi B, diphtheria corynebacterium, beta hemolysis streptococcus, Nai Shi mucositis bacterium, wherein the effect of Radix Polygoni Multiflori decocting liquid anti-Staphylococcus aureus is all strong than other processed products, and Radix Polygoni Multiflori Preparata decocting liquid is to Staphylococcus albus, wine steams Radix Polygoni Multiflori decocting liquid and Radix Rehmanniae juice steaming Radix Polygoni Multiflori decocting liquid is all better than raw product and other processed products to the rejection ability of diphtheria corynebacterium.
Radix Salviae Miltiorrhizae extract
Radix Salviae Miltiorrhizae extract is extracted by the dry root and rhizome of labiate Radix Salviae Miltiorrhizae SalviaMiltiorrhizae to process.Can effectively suppress skin lipid to be oxidized, improve local microcirculation, after TANSHINONES, salvianolic acid are absorbed by pore, subcutaneous blood circulation can be stimulated, suppress lipid oxidation reaction simultaneously, eliminate the acne, skin sore, the mottle that cause due to poor blood circulation, regulate water oil
Beneficial effect of the present invention:
Cosmetics of the present invention, reasonable recipe, the effect of raw material Nantural non-toxic evil, Be very effective.The crowd being applicable to any age bracket uses.
Detailed description of the invention
Embodiment 1
A skin-lightening cosmetic containing Radix Rhodiolae extract, Radix Polygoni Multiflori extract and Radix Salviae Miltiorrhizae extract, is made up of according to parts by weight following component:
Squalane 20 parts; 4 parts, paraffin; Semen Maydis oil extract 1 part; 1,3-PD 4 parts; Guar gum 0.5 part; Cremophor RH40 4 parts; Radix Rhodiolae extract 0.05 part; Radix Polygoni Multiflori extract 0.05 part; Radix Salviae Miltiorrhizae extract 0.05 part.
Said components is prepared into cosmetics traditionally.
Embodiment 2
A skin-lightening cosmetic containing Radix Rhodiolae extract, Radix Polygoni Multiflori extract and Radix Salviae Miltiorrhizae extract, is made up of according to parts by weight following component:
Squalane 25 parts; 5 parts, paraffin; Semen Maydis oil extract 2 parts; 1,3-PD 5 parts; Guar gum 1 part; Cremophor RH40 5 parts; Radix Rhodiolae extract 0.08 part; Radix Polygoni Multiflori extract 0.08 part; Radix Salviae Miltiorrhizae extract 0.08 part.
Said components is prepared into cosmetics traditionally.
Embodiment 3
A skin-lightening cosmetic containing Radix Rhodiolae extract, Radix Polygoni Multiflori extract and Radix Salviae Miltiorrhizae extract, is made up of according to parts by weight following component:
Squalane 30 parts; 6 parts, paraffin; Semen Maydis oil extract 3 parts; 1,3-PD 6 parts; Guar gum 1.5 parts; Cremophor RH40 6 parts; Radix Rhodiolae extract 0.1 part; Radix Polygoni Multiflori extract 0.1 part; Radix Salviae Miltiorrhizae extract 0.1 part.
Said components is prepared into cosmetics traditionally.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (2)
1. the skin-lightening cosmetic containing Radix Rhodiolae extract, Radix Polygoni Multiflori extract and Radix Salviae Miltiorrhizae extract, is characterized in that, be made up of following component according to parts by weight:
Squalane 20-30 part; Paraffin 4-6 part; Semen Maydis oil extract 1-3 part; 1,3-PD 4-6 part; Guar gum 0.5-1.5 part; Cremophor RH40 4-6 part; Radix Rhodiolae extract 0.05-0.1 part; Radix Polygoni Multiflori extract 0.05-0.1 part; Radix Salviae Miltiorrhizae extract 0.05-0.1 part.
2. a kind of skin-lightening cosmetic containing Radix Rhodiolae extract, Radix Polygoni Multiflori extract and Radix Salviae Miltiorrhizae extract according to claim 1, is characterized in that, be made up of following component according to parts by weight:
Squalane 25 parts; 5 parts, paraffin; Semen Maydis oil extract 2 parts; 1,3-PD 5 parts; Guar gum 1 part; Cremophor RH40 5 parts; Radix Rhodiolae extract 0.08 part; Radix Polygoni Multiflori extract 0.08 part; Radix Salviae Miltiorrhizae extract 0.08 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510962281.3A CN105496853A (en) | 2015-12-17 | 2015-12-17 | Skin-whitening cosmetic containing rhodiola rosea extract, polygonum multiflorum extract and salvia miltiorrhiza extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510962281.3A CN105496853A (en) | 2015-12-17 | 2015-12-17 | Skin-whitening cosmetic containing rhodiola rosea extract, polygonum multiflorum extract and salvia miltiorrhiza extract |
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| Publication Number | Publication Date |
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| CN105496853A true CN105496853A (en) | 2016-04-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510962281.3A Withdrawn CN105496853A (en) | 2015-12-17 | 2015-12-17 | Skin-whitening cosmetic containing rhodiola rosea extract, polygonum multiflorum extract and salvia miltiorrhiza extract |
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| CN (1) | CN105496853A (en) |
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