CN105495153A - Antioxidant health-care product containing phycocyanin and ginkgo leaf extracts - Google Patents
Antioxidant health-care product containing phycocyanin and ginkgo leaf extracts Download PDFInfo
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- CN105495153A CN105495153A CN201410546451.5A CN201410546451A CN105495153A CN 105495153 A CN105495153 A CN 105495153A CN 201410546451 A CN201410546451 A CN 201410546451A CN 105495153 A CN105495153 A CN 105495153A
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- phycocyanin
- ginkgo biloba
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Abstract
The invention relates to an antioxidant health-care product containing phycocyanin and a ginkgo leaf extract. The antioxidant health-care product is characterized by containing the phycocyanin and the ginkgo leaf extract in the weight ratio of the phycocyanin to the ginkgo leaf extract being (1-10) to (1-10). Pharmacological experiment researches prove that the health-care composition is better than a single extract in antioxidant activity, and the health-care product disclosed by the invention can be used as the antioxidant health-care product capable of effectively improving the function of a human body.
Description
Technical field
The present invention relates to food, health products and pharmaceutical field.
Background technology
Health products are the food with specific health care, only suitable specific crowd, but not for the purpose of disease therapy, the function of health products comprises: immunological regulation, adjusting blood lipid, adjustment blood sugar, delay senility, Improving memory, promotion lead discharging, regulate blood pressure, improving water flood, anti-sudden change, antifatigue, improve osteoporosis, improve alimentary anemia, improve gastrointestinal function etc.But existing health products to be arranged in pairs or groups science not to the utmost due to its component, therefore it is in the overall function of raising human body, the aspects such as anti-oxidant, antifatigue need further raising.
The oxidation of biomolecule is the process of a free radical mediated, and it can cause many adverse influences to food and biosystem.In aerobic organ, the free free radical relevant to the various diseases such as artery sclerosis, cancer can inevitably produce along with the process of oxygen metabolism.In vivo, antioxidation plays important function in maintenance body health.Common antioxidant (free radical scavenger) provides electronics to make asymmetric electronic stability paired to free radical.In this case, although antioxidant itself becomes free radical, this free radical is normally stable, and can be converted into non-free radical by all means.Therefore, the antioxidant finding safety is the study hotspot of biochemistry nutrition to suppress the generation of peroxide always.The chemical synthesis antioxidants such as BHT, TBHQ, owing to having good antioxidant effect and suitable price, are widely used in food, pharmaceuticals industry always.But along with improving constantly of human living standard, people are constantly risen to the demand from natural green pure natural.
Phycocyanin is one of chromoprotein that isolated a kind of occurring in nature is rare from spirulina, not only bright-colored, and itself is a kind of nutritious protein, and its amino acid composition is complete, and essential amino acids content is high.
Phycocyanin have anticancer, promote cell substitution, maintenance ovary, to impel in human body the effects such as synthesis elastin.Phycocyanin can also help to regulate, multiple important enzyme required for synthesized human metabolism, to the growth of inhibition cancer cell with promote human body cell regeneration, maintenance ovary, promote that synthesizing elastin in human body has important function, phycocyanin regulates human immune system simultaneously, strengthen function of immune system, improve human body to the resistance of disease, promote cytoactive, remove interior free yl, improve ovarian function, promote human body Fast back-projection algorithm elastin.
Ginkgo biloba p.e be with the leaf of ginkgo GinkgobilobaL. for raw material, adopt suitable solvent, a series products of the active ingredient enrichment of extraction.Take ginkgo biloba p.e as the various preparations that raw material is made, be widely used in the fields such as medicine, health products, food additives, functional beverage, cosmetics.
Ginkgo biloba p.e can promote the circulation of brain and body limb simultaneously, Platelet Activating Factor (PAF), and reduce platelet aggregation, neuroprotective cell is injury-free, and this function has the effect of supplemental treatment for the patient of apoplexy.Except suppressing thrombocyte adhesiveness, ginkgo biloba extract can also regulate antiotasis and elastic force, the cycle efficieny of the trunk (artery) in the lifting circulatory system and comparatively thin vessels (capillary); Ginkgo biloba p.e at brain, may can play anti-oxidation characteristics in eyeball retina and cardiovascular system.Its antioxidation in brain and central nervous system may contribute to the cerebral function decline prevented because the age causes.Brain and central nervous system are subject to free radical especially and attack.Free radical causes brain damage to be widely regarded as causing, with the old and feeble and influence factor of various diseases that is that come, wherein even comprising Alzheimer's disease; Ginkgo biloba p.e promotes cerebral blood flow and has fabulous tonic effect to nervous system.Hundreds of the scientific researches comprising patient up to ten thousand confirm that effect of ginkgo biloba p.e is to the effect of problems of intelelectual deterioration comprising the not enough and gerontal patient of cerebral blood flow.The possible symptom of ginkgo to many agings has good effect, such as: anxiety and melancholy, memory impairment, be difficult to focus one's attention on, dexterity declines, intelligence declines, dizzy, headache tinnitus (in ear ring), macula retinae portion degenerate (be grown up blind most common reason), inner ear disturbance (it can cause part to be become deaf), end circulation are bad.
Summary of the invention
The object of the present invention is to provide a kind of antioxidant health-care product containing phycocyanin and ginkgo biloba p.e, proved by pharmacological evaluation, phycocyanin and ginkgo biloba p.e compatibility can act synergistically, improve antioxidation activity, and develop immunitypty, the antifatigue effect of phycocyanin can be played, and clearing and activating the channels and collaterals, the function that stimulates circulation of ginkgo biloba p.e.Thus integrally-regulated function of human body, improve health quality.
Technical scheme of the present invention is:
A kind of antioxidant health-care product containing phycocyanin and ginkgo biloba p.e, it contains phycocyanin and ginkgo biloba p.e, weight ratio is phycocyanin: ginkgo biloba p.e=1 ~ 10:1 ~ 10, or is the phycocyanin of 1-10 part and the ginkgo biloba p.e of 10-1 part with parts by weight.Preferred weight ratio is: phycocyanin: ginkgo biloba p.e=1:1 or phycocyanin: ginkgo biloba p.e=1:2 or phycocyanin: ginkgo biloba p.e=2:1.
Antioxidant health-care product of the present invention, the content of wherein said total Content of Flavone Glycosides from Ginkgo biloba Extract alcohol glycosides is no less than 20% by weight.
Antioxidant health-care product of the present invention, it is further containing food and pharmaceutically acceptable auxiliary material, additive and/or excipient.
Antioxidant health-care product of the present invention has higher antioxidation activity, can develop immunitypty, antifatigue, clearing and activating the channels and collaterals, stimulate circulation.
Accompanying drawing explanation
Fig. 1 is that the cell viability between different experiments group compares.
Detailed description of the invention
For understanding essence of the present invention better, below by being described better embodiment of the present invention, describing the present invention in detail but not limiting the present invention.
The material used in following examples and reagent, except specified otherwise, be common commercially available.
Embodiment 1: prepared by medicine
Phycocyanin (lot number: 20131201, counts 25% with nitrogen content), ginkgo biloba p.e (lot number: 20131103 counts 31% with total flavonoids content) manufacturer are Shenzhen Haiwang Pharmaceutical Co., Ltd.
The content of phycocyanin measures according to n2 method (Chinese Pharmacopoeia 2010 editions one annex IXL second method).
The content of total Content of Flavone Glycosides from Ginkgo biloba Extract alcohol glycosides measures according to the content assaying method of total flavonoids under Chinese Pharmacopoeia 2010 editions ginkgo biloba p.e items.
Directly phycocyanin, ginkgo biloba p.e are prepared into following composition according to a certain ratio.
Composition 1: phycocyanin is 1:1 with the ratio of ginkgo biloba p.e weight;
Composition 2: phycocyanin is 2:1 with the ratio of ginkgo biloba p.e weight;
Composition 3: phycocyanin is 1:2 with the ratio of ginkgo biloba p.e weight;
Embodiment 2:H
2o
2cause preparation and the drug-treated of pancreas islet RIN-m model of cell apoptosis
Cell is with every hole 10
5the density of/mL is inoculated in 96 well culture plates, 37 DEG C, volume fraction 5%CO
2, under saturated humidity condition, overnight incubation makes cell completely adherent.Establish blank group, model group (H respectively
2o
2), ginkgo biloba p.e group (30 μ g/ml; 60 μ g/ml), phycocyanin group (30 μ g/ml; 60 μ g/ml), ginkgo leaf and phycocyanin mixture group, often organize at least 6 holes.Medicine, in 37 DEG C, after incubating 10h in advance, then adds the H that final concentration is 500 μm of ol/L
2o
2continue to cultivate 6h, then utilize MTT method to measure cell viability.At least 3 repeated experiments.The results are shown in Table 1 and Fig. 1:
Cell viability between different groups of table 1. compares (Mean ± S.D., n=4)
Experimental data shows, ginkgo biloba p.e and phycocyanin all have antioxidation in various degree, and the cell respectively through extract pre-administration can the cell death that causes of opposing peroxide in various degree.Ginkgo biloba p.e antioxidation is a little more than phycocyanin.
Ginkgo biloba p.e and phycocyanin are in varing proportions after proportioning, and antioxidation increases substantially, after will closing use with 30 μ g/ml separately, its cell viability be significantly higher than separately with 30 μ g/ml effects add with.By respective with after the concentration conbined usage of 60 μ g/ml, its cell viability be significantly higher than separately with 60 μ g/ml effects add with.By two kinds of compounds with after the mixing of different ratios, suppress separately peroxide cause the ability of cell death equally higher than adding of acting on respectively of corresponding respective concentration and.
The prompting of above result, ginkgo leaf extract with phycocyanin when antioxidation, may act on no approach or no action site, use in conjunction there is cooperative effect in both, and both are better than being used alone effect use in conjunction effect.
Prepared by embodiment 3 tablet
Just add one or more of the auxiliary materials such as starch, microcrystalline cellulose, lactose in 1 part of phycocyanin of weight ratio, 1 part of ginkgo biloba p.e, mixing, granulates, and dries, sieves, compressing tablet, the heavy 0.2-0.5g of every sheet, tablet of the present invention.
Prepared by embodiment 4 oral liquid
Be dissolved in water in 1 of weight ratio part of phycocyanin, 2 parts of ginkgo biloba p.es, add simple syrup, nipagin esters, benzoic acid, mixing after filling in coloured glass bottle, oral liquid of the present invention.
Prepared by embodiment 5 capsule
Just add one or more of the auxiliary materials such as starch, microcrystalline cellulose, lactose in 1 part of phycocyanin of weight ratio, 1 part of ginkgo biloba p.e, mixing, granulates, dry, sieve, encapsulated, the heavy 0.2-0.5g of every capsules content, capsule of the present invention.
Above detailed description of the present invention does not limit the present invention, and those skilled in the art can make various change and distortion according to the present invention, only otherwise depart from spirit of the present invention, all should belong to scope of the present invention.
Claims (6)
1. contain an antioxidant health-care product for phycocyanin and ginkgo biloba p.e, it is characterized in that: it contains phycocyanin and ginkgo biloba p.e, weight ratio is phycocyanin: ginkgo biloba p.e=1 ~ 10:1 ~ 10.
2. antioxidant health-care product as claimed in claim 1, is characterized in that the content of described total Content of Flavone Glycosides from Ginkgo biloba Extract alcohol glycosides is no less than 20% by weight.
3. antioxidant health-care product as claimed in claim 1, is characterized in that it consists of: phycocyanin by weight: ginkgo biloba p.e=1:1.
4. antioxidant health-care product as claimed in claim 1, is characterized in that it consists of: phycocyanin by weight: ginkgo biloba p.e=1:2.
5. antioxidant health-care product as claimed in claim 1, is characterized in that it consists of: phycocyanin by weight: ginkgo biloba p.e=2:1.
6. the antioxidant health-care product as described in any one of Claims 1 to 5, is characterized in that further containing food or pharmaceutically acceptable auxiliary material, additive and/or excipient.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109329934A (en) * | 2018-12-10 | 2019-02-15 | 丽江程海湖天然螺旋藻生产基地有限公司 | A kind of ginkgo spiral algae sheet of strengthen immunity and preparation method thereof |
| CN109497483A (en) * | 2018-01-26 | 2019-03-22 | 中国科学院烟台海岸带研究所 | One kind is containing phycocyanin and pine pollen composition and its preparation and application |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023156066A1 (en) * | 2022-02-17 | 2023-08-24 | The Boots Company Plc | Antioxidant compositions |
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| CN1593562A (en) * | 2004-07-05 | 2005-03-16 | 深圳海王药业有限公司 | Ginkgo leaf extract composition |
| CN101175417A (en) * | 2005-03-16 | 2008-05-07 | 让-路易·维达罗 | Spirulin composition rich in active principles, method for obtaining same and use thereof |
| CN101433574A (en) * | 2007-11-16 | 2009-05-20 | 北京因科瑞斯医药科技有限公司 | Composition with function for alleviating eyestrain and preparation method thereof |
| CN101703536A (en) * | 2009-07-22 | 2010-05-12 | 青岛农业大学 | Antitumor medicament with combination of spirulina polysaccharide and ginkgo-leaf effective components |
| CN101856374A (en) * | 2010-06-11 | 2010-10-13 | 青岛农业大学 | Anti-aging compound |
| CN103992402A (en) * | 2014-04-30 | 2014-08-20 | 中国药科大学 | Preparation method of high-purity phycocyanin |
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2014
- 2014-10-16 CN CN201410546451.5A patent/CN105495153B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1593562A (en) * | 2004-07-05 | 2005-03-16 | 深圳海王药业有限公司 | Ginkgo leaf extract composition |
| CN101175417A (en) * | 2005-03-16 | 2008-05-07 | 让-路易·维达罗 | Spirulin composition rich in active principles, method for obtaining same and use thereof |
| CN101433574A (en) * | 2007-11-16 | 2009-05-20 | 北京因科瑞斯医药科技有限公司 | Composition with function for alleviating eyestrain and preparation method thereof |
| CN101703536A (en) * | 2009-07-22 | 2010-05-12 | 青岛农业大学 | Antitumor medicament with combination of spirulina polysaccharide and ginkgo-leaf effective components |
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| CN103992402A (en) * | 2014-04-30 | 2014-08-20 | 中国药科大学 | Preparation method of high-purity phycocyanin |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109497483A (en) * | 2018-01-26 | 2019-03-22 | 中国科学院烟台海岸带研究所 | One kind is containing phycocyanin and pine pollen composition and its preparation and application |
| CN109329934A (en) * | 2018-12-10 | 2019-02-15 | 丽江程海湖天然螺旋藻生产基地有限公司 | A kind of ginkgo spiral algae sheet of strengthen immunity and preparation method thereof |
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