CN105494418A - Blocking agent for inhibiting infection of harmful microbes in fine particles in air - Google Patents
Blocking agent for inhibiting infection of harmful microbes in fine particles in air Download PDFInfo
- Publication number
- CN105494418A CN105494418A CN201410504767.8A CN201410504767A CN105494418A CN 105494418 A CN105494418 A CN 105494418A CN 201410504767 A CN201410504767 A CN 201410504767A CN 105494418 A CN105494418 A CN 105494418A
- Authority
- CN
- China
- Prior art keywords
- barrier
- fine particle
- harmful microorganism
- air
- antimicrobial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention provides a blocking agent for inhibiting infection of harmful microbes in fine particles in the air. The blocking agent comprises deoxyribonucleic acid, a humectant and an antimicrobial agent.
Description
Technical field
The present invention relates to and a kind ofly intercept based on natural animal-plant composition, fast and suppress the harmful microorganism in air fine particle to invade human contact's mucous membrane and bring out the barrier of the infected by microbes such as bacterium or virus.
Background technology
Be suspended in the fine particle in air, the harmful microorganisms such as the virus containing One's name is legion and noxious bacteria.These harmful microorganisms can, with air-flow or other particles for carrier, be suspended among air, by the breathing of people or mucocutaneously enter human body, cause bacterium and virus infections and respiratory tract or immune disease.Along with increasing the weight of and medium-term and long-termization of living environment Air Contamination, these harmful microbes are propagated and are threatened also normalization and malignization increasingly to the invasion of human body.When climate temperature is suitable for, more likely there is burst and spread, the health of people and composition of society one are endangered greatly.
For a long time, while people use antibiotic and antibacterial and antiviral drug to prevent or suppress harmful microbe to infect, the drug resistance of how to avoid antibacterial and antiviral drug also becomes a great problem suppressing harmful microorganism to infect field already.Along with a large amount of input and the use of the broad-spectrum antibacterial antiviral medicine constantly having renewal more powerful, harmful microbe drug resistance problems is serious increasingly.The birth of even most novel influenza is all come from drug resistance mutation unexpectedly.Existing expert gives a warning, the mankind may by face anti-bacteria and anti-virus class medicine lost efficacy comprehensively return anti-bacteria and anti-virus class medicine occur before that crisis of survival without the medicine anti-bacteria and anti-virus epoch.And, infect before occurring at the beginning of harmful microorganism invades, how effectively by play intercept and inhibitory action thus make harmful microorganism cannot then cause and infect or other stiff reaction aspects, simple dependence antimicrobial does not almost have effect.
How to use non-drug obstruct mode, before harmful microorganism in air particle invades human body initiation virus or bacteriological infection, by its shielding its active and diffusive infection can be suppressed effectively, the adjustment of human body self and the enhancing of immune resistivity is helped to promote the inherent defence capability tackling harmful microorganism intrusion, instead of invade just to come to throw in medicine in a large number after human body and kill at it, a large amount of precious useful bacterium and microorganism in body is caused again all to perish together while causing serious drug resistance, be related to the key subject how setting up new prophylactic treatment system.
In non-drug obstruct mode, as the simplest egodefense means of filtering and prevent the harmful microorganism in air particle from invading and harassing human body, mouth mask is still widely used so far.Although but mouth mask can intercept the diffusion of larger particles and saliva saliva star, and cannot the intrusion of the small harmful microorganism subparticle of shield diameter in fact, and with face fit not close, wear with inconvenience, damage beauty treatment and increase the weight of to breathe and bear, the defect such as cannot to use but very outstanding for a long time.
In recent years, prior art scheme proposes trial high molecular polymer, as polysaccharose pectin or carbohydrate gum realize intercepting the harmful microbe functions such as virus.But the method be made up of simple sticking ingredient, be difficult to fast and effeciently realize barriering effect, and due to the total obstruct to harmful microorganism particle can not be guaranteed, lack again and solve harmful microorganism once be adsorbed in mucous membrane and starting to cause the emergent suppression of stiff reaction generation infection to handle, become this method to be difficult to the fatal difficult point of extensive use.
Separately have a kind of technical scheme proposition carbohydrate gum and antimicrobial combination to suppress harmful microbe method, wish solve harmful microorganism once be adsorbed in mucous membrane start occur infect inhibition on promote to some extent.It is the viscous ingredients that the iris action owing to invading at shielding harmful microorganism particle only relies on single carbohydrate gum self to have, functionally there is larger limitation, barriering effect is also not obvious, and after using, easily cause the foreign body sensation sense of discomfort of skin or mucous membrane, be difficult to reach the affine experience of good mucous membrane.In the antimicrobial of this external input combination, only be confined to some and be proved to be the larger chemosynthesis medicament composition of drug resistance risk, and be proved to be effective and side effect less or have no side effect refine the antimicrobial composition of composition from natural plants, be then almost completely neglected.
Summary of the invention
In order to overcome the defect existed in prior art, the invention provides a kind of non-drug and acting on human body, prevent harmful microorganism from entering human body and cause infection, suppress the barrier that in air fine particle, harmful microorganism infects.
In order to realize foregoing invention object, the invention provides a kind of barrier suppressing harmful microorganism infection in air fine particle, comprising: DNA (deoxyribonucleic acid), humectant and antimicrobial.
Further, this DNA (deoxyribonucleic acid) is Sodium deoxyribonucleate.
Further, this DNA (deoxyribonucleic acid), humectant and antimicrobial meet following weight ratio: 0.2%≤DNA (deoxyribonucleic acid)≤3.5%; 2.0%≤humectant≤20%; 0.01%≤antimicrobial≤2%.
Further, this barrier also comprises pectin, and this pectin meets following weight ratio: 0.05%≤pectin≤3.5%.
Further, this barrier also comprises water soluble chitosan, and this water soluble chitosan meets following weight ratio: 0.1%≤water soluble chitosan≤8%.
Further, this barrier also comprises ethanol, and this ethanol meets following weight ratio: 2.0%≤ethanol≤25%.
Further, this barrier also comprises butanediol, and this butanediol meets following weight ratio: 1.2%≤butanediol≤20%.
Further, this antimicrobial is the antimicrobial extracted from natural plants.
Further, the pH value of this barrier is 5.5-7.
Further, it is characterized in that, this barrier is used for skin or mucomembranous surface.
Further, it is characterized in that, this barrier is sprayed at oral cavity or nostril, or be attached to mouth mask with spraying or immersion liquid mode, nasal obstruction, air filtering are online, or directly to spray in suffering in the air that harmful microorganism pollutes or body surface.
Compared with prior art, but barrier provided by the present invention stops up based on shielding, and it is auxiliary that antibiosis is killed; Non-drug is this, medicine is for mending as feature, by combination formula and the mode of action of uniqueness, fast and effeciently can to intercept in air fine particle harmful microbe to invade and harass, suppress and remove other comparable product numerous even medicine insoluble because of harmful microorganism subparticle invade and harass bring allergy, infection and other stiff reactions.
The effect of barrier provided by the present invention comprises: in air fine particle harmful microorganism invade when quick-acting and strong shielding intercept and harmful microorganism once invade after timely resistance and kill.Namely first invisible barrier layer is formed by the interaction of DNA (deoxyribonucleic acid) and humectant at human body mucomembranous surface, intercept, adsorb and condense the harmful microorganism particle in air fine particle quickly and effectively, make its inactivation that condenses, mucous membrane cannot be contacted and then cause the various pathology reactions such as irritated infection; Again by the compound action of antimicrobial composition, kill in time once slip through the net and invade and contact the harmful microorganism of mucous membrane, or it copies breeding and diffusion to intercept interference, effectively suppresses infection and the infection of harmful microorganism initiation.
Barrier provided by the present invention, utilizes the distinctive large molecule double-spiral structure of DNA (deoxyribonucleic acid) and viscosity characteristics, fast and effeciently can adsorb and catch and cohesion fine particle; Simultaneously by the combination of humectant composition, the architectural characteristic of stabilized deoxy ribonucleic acid better, maintain it more enduringly as the state and the environment that intercept composition, and can adjust and strengthen iris actions such as adhering to cohesion better, keep the best affine state of mucous membrane; Or add water distribution soluble chitosan or pectin to strengthen its absorption and catch and the effect of cohesion and lasts thereof; Add simultaneously and be equipped with micro-antimicrobial composition, to strengthen the effect that harmful microbe is bred and diffusion, anti-bacteria and anti-virus etc. suppress harmful microorganism to infect that the follow-up obstruct interference of obstruct process invades mucous membrane.
Barrier provided by the present invention, has than similar or similar articles that the mode of action is unique more to be optimized, the faster more obviously feature of barriering effect.Compare the method for single use DNA (deoxyribonucleic acid) or carbohydrate gum glycerols viscous ingredients, barriering effect is quicker effectively, more lastingly stable, suppresses the effect infecting diffusion more remarkable.Compared with the method killed with single use antibacterial and antiviral drug, then can greatly reduce drug resistance evils and risk, improve the environment of antimicrobial at mucous membrane, intercept and shield harmful microorganism intrusion and suppress the effect of infection diffusion generation also more direct and simple.And in composition combination matching of the present invention, the absorption of DNA (deoxyribonucleic acid) catches and the architectural characteristic of cohesion harmful microorganism subparticle can obtain more fully more effectively playing, and mucous membrane compatibility is better more lasting; Add the optimum organization being equipped with micro-antimicrobial and other thickness such as humectant or pectin obstruct composition, with carbohydrate gum compared with the method for antimicrobial combination, it intercepts harmful microorganism and invades and suppress the effect of infection more obviously more effective more rapidly, and foreign sense sense of discomfort, mucous membrane compatibility is also better more lasting.
The pH value of barrier provided by the present invention adjusts between 5.5-7, to strengthen the compatibility of mucous membrane skin and to resist the ability that in extraneous fine particle, harmful microorganism is invaded and harassed.
The material that barrier composition provided by the present invention all comes from natural animal-plant extractive matter, is acknowledged as avirulence, has no side effect, stable performance, mucous membrane is affine, and experience is good, can be applicable to the long-time use of the different crowds such as the pregnant baby weakling of men and women, old and young under Various Seasonal, different occasion.
Barrier provided by the present invention, directly acts on the invisible liquid barrier film cover of Mucocutaneous special no color or smell as a kind of, can replace the effect of most of mouth mask.Can solve usually wear bring with mouth mask be difficult to laminating face, wear with inconvenience, damage beauty treatment, and increase and breathe burden, the defect such as cannot to use for a long time.
Barrier provided by the present invention, with the liquid form that a kind of no color or smell is invisible, any intermediaries such as filtering screen of can having a stuffy nose with mouth mask easily realize folded with or combines, strengthen the barriering effect of described barrier with applicable different user demand.
Barrier provided by the present invention, adopts spray pattern directly to spray in human body skin and interior transmucosal.Not by under the state of cleaning, at skin or the sustainable 2-6 hour of mucous membrane spraying position barriering effect.
Accompanying drawing explanation
Can be further understood by following detailed Description Of The Invention and institute's accompanying drawings about the advantages and spirit of the present invention.
Fig. 1 is particle different conditions figure under the microscope;
Fig. 2 is the technical schematic diagram of barrier involved in the present invention;
Fig. 3 is the experiment effect figure of barrier involved in the present invention.
Embodiment
Specific embodiments of the invention are described in detail below in conjunction with accompanying drawing.
Due to how intercepting in the known invention and method suppressing harmful microorganism to invade infection, there is different defects: as single polysaccharose viscous ingredients, mucous membrane compatibility is poor, being difficult to fast and effeciently realize barriering effect; And the total obstruct can not guaranteeing harmful microorganism particle, lack again and solve harmful microorganism once be adsorbed in mucous membrane and emergently handling of starting to cause stiff reaction to occur to infect; Single antimicrobial composition, brings serious drug resistance risk killing harmful microbe simultaneously, and cannot at the beginning of harmful microorganism invades in addition shielding effectively; And with the composition of carbohydrate gum and antimicrobial combination, although the effect making suppression infect because of the input of antimicrobial is strengthened, but drug resistance risk still cannot effectively be evaded, and the barriering effect of single carbohydrate gum viscous ingredients is not remarkable, there is the limitation that mucous membrane compatibility difference has sense of discomfort on the contrary.
The object of the present invention is to provide a kind of by disturbing based on non-medical ingredients composition, the effectively intrusion of obstruct harmful microorganism particle, suppress its contact mucous membrane and bring out the reaction of the pathology such as bacterium or virus infections, and once suffer harmful microorganism particle to invade the barrier that can killed rapidly or suppress.This barrier, first passes through the interaction of DNA (deoxyribonucleic acid) and the humectant extracted from natural food, forms invisible barrier layer at mucomembranous surface.When invaded by the harmful microorganism particle in air fine particle, directly can intercept, adsorb and condense harmful microorganism particle quickly and effectively outward at mucosal surface, make its inactivation that condenses, directly cannot contact mucous membrane and then cause the various pathology reactions such as irritated infection, reaching and suppress harmful microbe effect.The environment of antimicrobial on mucous membrane can also be regulated, the action effect of strengthening antimicrobial simultaneously.And the antimicrobial composition by being furnished with in barrier, then can kill rapidly once invade and contact the harmful microorganism of mucous membrane or intercept rapidly their breeding of interference and diffusion, effectively suppress the infection that causes thus and the reaction of other pathologies.
Well, safety has no side effect the affine experience of barrier mucous membrane provided by the present invention, and different crowd all can use for a long time under different occasion.
Fig. 1 is DNA macromolecules adsorption principle schematic.In Fig. 1, left figure contains harmful microbe fine particle under suspended state, mutually repels, becomes irregular point of cloth-like; Middle figure is connected so that particle can be impelled after pectin composition to adhere to through spraying, and chaining is in a row; Right figure is through spraying to impel particle aggegation to be polymerized after Sodium deoxyribonucleate, agglomerating one-tenth block, sclerosis inactivation, the surface-active of suspended particulate substance and effectively intercepted with mucosal contact and suppress.As seen from Figure 1, pectin and Sodium deoxyribonucleate all have the effect of absorption and aggegation fine particle, more remarkable with the effect that the absorption aggegation of DNA (deoxyribonucleic acid) is also polymerized.
Fig. 2 shows the interactively of each element.The usual multi-band positive charge of fine particle in air, through electronegative and have double-spiral structure and adsorb coherent packet mutually with the large molecule DNA (deoxyribonucleic acid) of adhesion characteristics and cover and become block; There is the humectant of certain adsorption-condensation ability, more by the interaction with DNA (deoxyribonucleic acid), significantly improve and stablize maintenance to obstructing capacities such as the adsorption-condensations containing harmful microorganism fine particle; Antimicrobial then coordinates obstruct process and and then the harmful microorganism killed in fine particle or suppress its breeding dispersal and cause to infect.
Fig. 3 be presented at mouth mask be intermediary carrier embodiment in, the obstruct spraying described barrier is containing the measure of merit example of harmful microbe fine particle.Epimere is test lead, uses common anti-dust respirator, adds water spray or this agent respectively, detects the barriering effect of particle under each condition.A1 is the insulation amount of contrast 1 mouth mask; B1 is the insulation amount that contrast 2 mouth mask adds spray distilled water; C1 is the insulation amount that mouth mask adds this barrier of spray.Hypomere is inspection end, uses the Special Medical dust and bacteria removing mouth mask of particle rejection rate nearly 100%, detect anti-dust respirator under each collating condition intercept after particle residue amount (concentration yardstick).A2 is residual quantity after contrast 1 mouth mask intercepts; B2 is that contrast 2 mouth mask adds the rear residual quantity of spray distilled water obstruct; C2 is that mouth mask adds the rear residual quantity of this barrier of spray obstruct.Method is, respectively from the control casing of suspended particulate substance being full of equivalent drying, after front and back divide two sections to attract by same instrument, mode, attraction and pull up time (30 seconds), measures the particle amount that mouth mask surface is intercepted by sorption.After first paragraph filters and intercepts through the different measured body cover of ABC, records insulation amount, second segment intercepts it with professional filter mantle again and omits residual particle amount and compared.Be that add the mouth mask that sprays described barrier to about common mouth mask or mouth mask adding distil water more than 1 times of the insulation amount of particle, after adding the obstruct of the mouth mask spraying described barrier, residual particles amount is below the half of common mouth mask according to concentration scale its result visible.
Table 1 shows one containing Sodium deoxyribonucleate, humectant, antimicrobial, or one contains Sodium deoxyribonucleate, humectant, antimicrobial also adds and joins in the mouth sprays embodiment of pectin, when in the environment more containing harmful microbial air fine particle, spray the every effect after described barrier, comprise and suck barriering effect containing harmful microorganism fine particle, active suppression and insect killing effect, infect and infect inhibition, pharyngeal sense of discomfort is improved and mucous membrane compatibility (foreign sense sense of discomfort), lasts, the side effects etc. such as drug resistance, than the effect only using single-copy DNA sodium composition in proportion or single pectin composition or single antimicrobial composition in proportion in proportion, have and significantly promote and improve.Especially, in very important when intercepting articles for use use as conventional anti-harmful microorganism lasts, mucous membrane compatibility (foreign sense sense of discomfort) and side effect, the lifting of performance and effect is more remarkable.
Table 1
DNA (deoxyribonucleic acid) mentioned by the present invention takes from the refinement composition of fish, especially best with Sodium deoxyribonucleate (DNA-Na) technique effect.
Humectant mentioned in the present invention is the humectant that single moisturizing agent composition or multiple humectant composition combine.Include but not limited to one or more following humectant compositions: as polyalcohols humectant such as glycerine, polyethylene glycol, propane diols, hexylene glycol, polypropylene glycol, xylitol, sorbitol and composition thereof; The biochemical class humectant compositions such as collagen, mucopolysaccharides body, hyaluronic acid, glycoprotein and chondroitin sulfate; Amino acids humectant composition; Dexpanthenol, ceramide and other NMF compositions etc.
Antimicrobial mentioned by the present invention, comprises antibacterial agent, antivirotic and preservative.Comprise medicine type antimicrobial composition and non-drug type antimicrobial composition, with non-drug type antimicrobial for Main Function composition.Non-drug type antimicrobial composition comprises the antimicrobial composition that single one or more natural plants refinement composition combines, and includes but not limited to kitchen garden, granatum, cordate houttuynia, folium isatidis, climbing groundsel, the coptis, the root of large-flowered skullcap, herba fibraureae recisae, trollflower, picria fel tarrae, Radix Isatidis, radix rehmanniae recen, root tuber of aromatic turmeric, the wind-weed, BAIXINCAO, Pogostemon cablin, grass-leaved sweetflag, Radix Glycyrrhizae, fennel, hawthorn, Chinese juniper leaf, barberry etc.Medicine type antimicrobial composition includes but not limited to the antiviral antibacterial compositions such as Oseltamivir (Oseltamivir), zanamivir (Zanamivir), Peramivir (Peramivir), La Nina meter Wei (Laninamivir) and cetylpyridinium chloride(CPC) (Cetylpyridiniumchloride).Medicine type antimicrobial mentioned by the present invention is under prior art gets permission by pharmacological evaluation the common medicine that uses.
The refinement composition of fruit thing taken from by pectin (Pectin) mentioned by the present invention.
Ethanol (Ethanol) mentioned by the present invention is taken from processing that is sugary or starchy plant and is refined composition.
Butanediol (ButyleneGlycol) mentioned by the present invention is efficient stable performance agent and bacteriostatic agent composition except Hydrolyzed Protein effect.
Barrier provided by the present invention, prepares by following method: added by Sodium deoxyribonucleate in part Purified Water and dissolve to obtain solution A, and solution B is heated to obtain in each for humectant composition mixing, solution A, solution B are mixed thoroughly, add the remaining Purified Water of institute, adjust pH to 5.5 ~ 7, sterilization packaging forms.Add when joining antimicrobial composition, first antimicrobial can be dissolved in part Purified Water and obtain solution C, then solution A, solution B, solution C be mixed thoroughly, add the remaining Purified Water of institute, adjust pH to 5.5 ~ 7, sterilization packaging forms.Add when joining other compositions, first pectin can be added part Purified Water and heat to obtain solution D, then solution A, solution B, solution C, solution D or solution A, solution B, solution D be mixed thoroughly, add the remaining Purified Water of institute, adjust pH to 5.5 ~ 7, sterilization packaging forms.Or first butanediol is added part Purified Water and dissolve to obtain solution E, then solution A, solution B, solution D, solution E or solution A, solution B, solution C, solution D, solution E are mixed thoroughly, add the remaining Purified Water of institute, adjust pH to 5.5 ~ 7, sterilization packaging forms.Or solution A, solution B, solution D, solution E or solution A, solution B, solution C, solution D, solution E are mixed thoroughly, allocate ethanol into, add the remaining Purified Water of institute, adjust pH to 5.5 ~ 7, sterilization packaging forms.
Ultimate constituent ratio meets following weight ratio:
0.2%≤DNA (deoxyribonucleic acid)≤3.5%, 2.0%≤humectant≤20%, 0.00%≤antimicrobial≤2%, 0.2%≤pectin≤3.5%, 4%≤butanediol≤10%, 2.0%≤ethanol≤15%.
first embodiment
A kind of form with the face carried, oral cavity and ear nose eye spray is provided fast and effeciently to intercept, stop, suppress and eliminate the method that in air fine particle, harmful microorganism is invaded and harassed so that infected in first embodiment.In described method, composition DNA (deoxyribonucleic acid) gets Sodium deoxyribonucleate, adds and is furnished with humectant and Purified Water.
In described embodiment, Sodium deoxyribonucleate content is greater than and 0.08% is less than 1.6%, content of humectant be greater than 6.0% be less than 20%, surplus joins Purified Water, adjust pH to 5.5 ~ 7.
In described embodiment, Sodium deoxyribonucleate is taken from the refinement composition of fish, and molecular weight is at more than 30kDa, electronegative, has vigor and the effect of very strong adsorption-condensation molecule.In described barrier, stop up for realizing sorption cohesion the Main Function composition pressing down harmful microorganism and activity thereof in fine particle with Sodium deoxyribonucleate; Add and be equipped with humectant with stable and adjust the architectural characteristic of each composition, active state and environment, extend the iris action time, keep the affine state of best mucous membrane, and make adhesion cohesion etc. intercept harmful microbe effect in fine particle to be strengthened; Add and be equipped with Purified Water to dilute each action component to the best use of concentration.
In described embodiment, spray pattern is adopted directly to spray in human body skin and interior transmucosal.During use, the amount of spraying is depending on spraying position and amblent air temperature and adjusting, and is generally to be greater than 0.01ml and to be less than 0.5ml.Not by under the state of cleaning, at skin or the sustainable 2-6 hour of mucous membrane spraying position barriering effect.
Under the effect of described embodiment, fast and effeciently can intercept harmful microbe in air fine particle to invade and harass, suppress and even kill harmful microbe activity, suppressing and remove other comparable product numerous even medicine institute is insoluble to suck allergy that invasion causes, infection and other stiff reactions because of harmful microorganism in air fine particle.Form the liquid barrier film cover that no color or smell is invisible.Safety has no side effect.The effect of most of mouth mask can be replaced.Through being that the folded test result of intermediary shows with mouth mask, when spraying described barrier, the insulation amount of particle about more than 1 times of common mouth mask or mouth mask adding distil water, and once intercepts rear residual particles amount below the half of common mouth mask.
second embodiment
In second embodiment, a kind of form with the face carried, oral cavity and ear nose eye spray is provided fast and effeciently to intercept, stop, suppress and eliminate the method that in air, in fine particle, harmful microorganism is invaded and harassed so that infected.In described method, composition DNA (deoxyribonucleic acid) gets Sodium deoxyribonucleate, adds and is furnished with water soluble chitosan or changes with pectin or the mixture that changes with shitosan and pectin, add and be furnished with humectant and Purified Water.
In described embodiment, Sodium deoxyribonucleate content is greater than and 0.08% is less than 1.0%, water soluble chitosan content is greater than 0.1% and is less than 6% or change and be greater than 0.05% with pectin content and be less than 2.5% or change and be greater than 0.1% with the content of shitosan and pectin mixture and be less than 7%, content of humectant is greater than 2.0% and is less than 18%, surplus joins Purified Water, adjust pH to 5.5 ~ 7.
In described embodiment, Sodium deoxyribonucleate is taken from the refinement composition of fish, and molecular weight is at more than 30kDa, electronegative, has vigor and the effect of very strong adsorption-condensation molecule.Pectin is taken from the refinement composition of natural fruit thing, and molecular weight is at more than 30kDa.Shitosan water-soluble constituent of chitosan.Stop up for realizing sorption cohesion the Main Function composition pressing down harmful microorganism and activity thereof in fine particle with Sodium deoxyribonucleate; Add the blending constituent being equipped with pectin or water soluble chitosan or pectin and water soluble chitosan and adhere to harmful microbe performance in fine particle to strengthen and to stablize; Add and be equipped with humectant with stable and adjust the architectural characteristic of each composition, active state and environment, extend the iris action time, keep the affine state of best mucous membrane, and make adhesion cohesion etc. intercept harmful microbe effect in fine particle to be strengthened; Add and be equipped with Purified Water to dilute each action component to the best use of concentration.
In described embodiment, spray pattern is adopted directly to spray in human body skin and interior transmucosal.During use, the amount of spraying is depending on spraying position and amblent air temperature and adjusting, and is generally to be greater than 0.01ml and to be less than 0.5ml.Not by under the state of cleaning, at skin or the sustainable 2-6 hour of mucous membrane spraying position barriering effect.
Under the effect of described embodiment, fast and effeciently can to intercept in air harmful microbe in fine particle to invade and harass, suppress and remove other comparable product numerous even medicine institute is insoluble to suck allergy that invasion causes, infection and other stiff reactions because of harmful microorganism in air fine particle.Form the liquid barrier film cover that no color or smell is invisible.Safety has no side effect.The effect of most of mouth mask can be replaced.Through being that the folded test result of intermediary shows with mouth mask, when spraying described barrier, the insulation amount of particle about more than 1 times of common mouth mask or mouth mask adding distil water, and once intercepts rear residual particles amount below the half of common mouth mask.
3rd embodiment
In 3rd embodiment, a kind of form with the face carried, oral cavity and ear nose eye spray is provided fast and effeciently to intercept, stop, suppress and eliminate the method that in air fine particle, harmful microorganism is invaded and harassed so that infected.In described method, composition DNA (deoxyribonucleic acid) gets Sodium deoxyribonucleate, adds and is furnished with humectant, adds and is furnished with antimicrobial and Purified Water.
In described embodiment, Sodium deoxyribonucleate content is greater than 0.18% and is less than 3.5%, and content of humectant is greater than 6.0% and is less than 20%, and antimicrobial agent content is greater than 0.01% and is less than 1.0%, and surplus joins Purified Water, adjust pH to 5.5 ~ 7.
In described embodiment, Sodium deoxyribonucleate is taken from the refinement composition of fish, and molecular weight is at more than 30kDa, electronegative, has vigor and the effect of very strong adsorption-condensation molecule.Stop up for realizing sorption cohesion the Main Function composition pressing down harmful microorganism and activity thereof in fine particle with Sodium deoxyribonucleate; Add and be equipped with antimicrobial composition and be taken from natural animal-plant and refine composition, to kill in time once invade and contact the harmful microorganism of mucous membrane or intercept rapidly its breeding of interference and diffusion, effectively suppress harmful microorganism to infect and infection; Add and be equipped with humectant with stable and adjust the architectural characteristic of each composition, active state and environment, extend the iris action time, keep the affine state of best mucous membrane, and make adhesion cohesion etc. intercept harmful microbe effect in fine particle to be strengthened; Add and be equipped with Purified Water to dilute each action component to the best use of concentration.
In described embodiment, spray pattern is adopted directly to spray in human body skin and interior transmucosal.During use, the amount of spraying is depending on spraying position and amblent air temperature and adjusting, and is generally to be greater than 0.01ml and to be less than 0.5ml.Not by under the state of cleaning, at skin or the sustainable 2-6 hour of mucous membrane spraying position barriering effect.
Under the effect of described embodiment, fast and effeciently can to intercept in air fine particle harmful microbe to invade and harass, suppress and remove other comparable product numerous even medicine institute is insoluble to suck allergy that invasion causes, infection and other stiff reactions because of harmful microorganism in air fine particle.Form the liquid barrier film cover that no color or smell is invisible.Safety has no side effect.The effect of most of mouth mask can be replaced.Through being that the folded test result of intermediary shows with mouth mask, when spraying described barrier, the insulation amount of particle about more than 1 times of common mouth mask or mouth mask adding distil water, and once intercepts rear residual particles amount below the half of common mouth mask.
4th embodiment
In 4th embodiment, a kind of form with the face carried, oral cavity and ear nose eye spray is provided fast and effeciently to intercept, stop, suppress and eliminate the method that in air fine particle, harmful microorganism is invaded and harassed so that infected.In described method, composition DNA (deoxyribonucleic acid) gets Sodium deoxyribonucleate, adds and is furnished with humectant, adds to be furnished with antimicrobial, to add and be furnished with water soluble chitosan or change with pectin or change with the mixture of shitosan and pectin and Purified Water.
In described embodiment, Sodium deoxyribonucleate content is greater than 0.18% and is less than 3.5%, content of humectant is greater than 6.0% and is less than 20%, antimicrobial agent content is greater than 0.01% and is less than 2.0%, or add water distribution soluble chitosan content and be greater than 0.1% and be less than 5% or add and join pectin content and be greater than 0.0% and be less than 1.0% or add the content of joining shitosan and pectin mixture and be greater than 0.1% and be less than 6%, surplus joins Purified Water, adjust pH to 5.5 ~ 7.
In described embodiment, Sodium deoxyribonucleate is taken from the refinement composition of fish, and molecular weight is at more than 30kDa, electronegative, has vigor and the effect of very strong adsorption-condensation molecule.Stop up for realizing sorption cohesion the Main Function composition pressing down harmful microorganism and activity thereof in fine particle with Sodium deoxyribonucleate; Add and be equipped with antimicrobial composition and be taken from natural animal-plant and refine composition, to kill in time once invade and contact the harmful microorganism of mucous membrane or intercept rapidly its breeding of interference and diffusion, effectively suppress harmful microorganism to infect and infection; Add and be equipped with humectant with stable and adjust the architectural characteristic of each composition, active state and environment, extend the iris action time, keep the affine state of best mucous membrane, and make adhesion cohesion etc. intercept harmful microbe effect in fine particle to be strengthened; Add and be equipped with Purified Water to dilute each action component to the best use of concentration.
In described embodiment, spray pattern is adopted directly to spray in human body skin and interior transmucosal.During use, the amount of spraying is depending on spraying position and amblent air temperature and adjusting, and is generally to be greater than 0.01ml and to be less than 0.5ml.Not by under the state of cleaning, at skin or the sustainable 2-6 hour of mucous membrane spraying position barriering effect.
Under the effect of described embodiment, fast and effeciently can to intercept in air fine particle harmful microbe to invade and harass, suppress and remove other comparable product numerous even medicine institute is insoluble to suck allergy that invasion causes, infection and other stiff reactions because of harmful microorganism in air fine particle.Form the liquid barrier film cover that no color or smell is invisible.Safety has no side effect.The effect of most of mouth mask can be replaced.Through being that the folded test result of intermediary shows with mouth mask, when spraying described barrier, the insulation amount of particle about more than 1 times of common mouth mask or mouth mask adding distil water, and once intercepts rear residual particles amount below the half of common mouth mask.
5th embodiment
In 5th embodiment, a kind of form with the mouth sprays carried is provided fast and effeciently to intercept, stop, suppress and eliminate the method that in air fine particle, harmful microorganism is invaded and harassed so that infected.In described method, composition DNA (deoxyribonucleic acid) gets Sodium deoxyribonucleate, adds and is furnished with humectant, adds and is furnished with antimicrobial, adds and is furnished with ethanol, or adds and be furnished with water soluble chitosan or change with pectin or change with the mixture of shitosan and pectin and Purified Water.
In described embodiment, Sodium deoxyribonucleate content is greater than 0.08% and is less than 2.0%, antimicrobial agent content is greater than 0.01% and is less than 2.0%, content of humectant is greater than 6.0% and is less than 20%, ethanol content is greater than 2% and is less than 25%, or add water distribution soluble chitosan content and be greater than 0.1% and be less than 5% or add and join pectin content and be greater than 0.0% and be less than 1.0% or add the content of joining shitosan and pectin mixture and be greater than 0.1% and be less than 6%, surplus joins Purified Water, adjust pH to 5.5 ~ 7.
In described embodiment, Sodium deoxyribonucleate is taken from the refinement composition of fish, and molecular weight is at more than 30kDa, electronegative, has vigor and the effect of very strong adsorption-condensation molecule.Stop up for realizing sorption cohesion the Main Function composition pressing down harmful microorganism and activity thereof in fine particle with Sodium deoxyribonucleate; Add and be equipped with antimicrobial composition and be taken from natural animal-plant and refine composition, to kill in time once invade and contact the harmful microorganism of mucous membrane or intercept rapidly its breeding of interference and diffusion, effectively suppress harmful microorganism infection; Or add be equipped with water soluble chitosan or pectin or water soluble chitosan and pectin blending constituent to strengthen and harmful microbe performance in stable adhered particles thing; Add and be equipped with ethanol to strengthen antibacterial effect and preparation adjustment; Add and be equipped with humectant with stable and adjust the architectural characteristic of each composition, active state and environment, extend the iris action time, keep the affine state of best mucous membrane, and make adhesion cohesion etc. intercept harmful microbe effect in fine particle to be strengthened; Add and be equipped with Purified Water to dilute each action component to the best use of concentration.
In described embodiment, spray pattern is adopted directly to spray mucosa in human oral cavity.During use, the amount of spraying is depending on spraying position and amblent air temperature and adjusting, and is generally to be greater than 0.01ml and to be less than 0.5ml.Not by under the state of cleaning, at the sustainable 2-6 hour of mucous membrane spraying position barriering effect.
Under the effect of described embodiment, fast and effeciently can intercept the intrusion of harmful microorganism direct oral cavity and interference in fine particle in air, suppress and remove other comparable product numerous even medicine institute insoluble because of harmful microorganism in air fine particle suck invade and harass cause allergy, infection and other stiff reactions, for intercepting virus and bacteria and smog and suppressing it to have good effect to the stimulation of bottleneck throat.The liquid barrier film cover that no color or smell is invisible can be formed.Safety has no side effect.The effect of most of mouth mask can be replaced.Through being that the folded test result of intermediary shows with mouth mask, when spraying described barrier, the insulation amount of particle about more than 1 times of common mouth mask or mouth mask adding distil water, and once intercepts rear residual particles amount below the half of common mouth mask.
6th embodiment
In 6th embodiment, a kind of form with mouthwash is provided fast and effeciently to intercept, stop, suppress and eliminate the method that in air fine particle, harmful microorganism is invaded and harassed so that infected.In described method, composition DNA (deoxyribonucleic acid) gets Sodium deoxyribonucleate, adds and is furnished with humectant, adds and is furnished with antimicrobial, adds and is furnished with ethanol, or adds and be furnished with water soluble chitosan or change with pectin or the mixture that changes with shitosan and pectin; And Purified Water.
In described embodiment, Sodium deoxyribonucleate content is greater than 0.08% and is less than 2.0%, antimicrobial agent content is greater than 0.01% and is less than 2.0%, content of humectant is greater than 6.0% and is less than 20%, ethanol content is greater than 2% and is less than 25%, or add water distribution soluble chitosan content and be greater than 0.1% and be less than 5% or add and join pectin content and be greater than 0.0% and be less than 1.0% or add the content of joining shitosan and pectin mixture and be greater than 0.1% and be less than 6%, surplus joins Purified Water, adjust pH to 5.5 ~ 7.
In described embodiment, Sodium deoxyribonucleate is taken from the refinement composition of fish, and molecular weight is at more than 30kDa, electronegative, has vigor and the effect of very strong adsorption-condensation molecule.Stop up for realizing sorption cohesion the Main Function composition pressing down harmful microorganism and activity thereof in fine particle with Sodium deoxyribonucleate; Add and be equipped with antimicrobial composition and be taken from natural animal-plant and refine composition, to kill in time once invade and contact the harmful microorganism of mucous membrane or intercept rapidly its breeding of interference and diffusion, effectively suppress harmful microorganism infection; Or add be equipped with water soluble chitosan or pectin or water soluble chitosan and pectin blending constituent to strengthen and harmful microbe performance in stable adhered particles thing; Add and be equipped with ethanol to strengthen antibacterial effect and preparation adjustment; Add and be equipped with humectant with stable and adjust the architectural characteristic of each composition, active state and environment, extend the iris action time, keep the affine state of best mucous membrane, and make adhesion cohesion etc. intercept harmful microbe effect in fine particle to be strengthened; Add and be equipped with Purified Water to dilute each action component to the best use of concentration.
In described embodiment, adopt and act on mucosa in human oral cavity containing the mode of gargling.Usage amount is visual to be adjusted containing the needs gargled.Not by under the state of cleaning, at the sustainable 2-6 hour of mucous membrane attachment area barriering effect.Also the pharyngeal fine particle in oral cavity is sucked by gargling to wash directly to remove.
Under the effect of described embodiment, fast and effeciently can intercept the intrusion of harmful microorganism direct oral cavity and interference in fine particle in air, suppress and remove other comparable product numerous even medicine institute insoluble because of harmful microorganism in air fine particle suck invade and harass cause allergy, infection and other stiff reactions, for intercepting virus and bacteria and smog and suppressing it to have good effect to the stimulation of bottleneck throat.The liquid barrier film cover that no color or smell is invisible can be formed.Safety has no side effect.The effect of most of mouth mask can be replaced.Through being that the folded test result of intermediary shows with mouth mask, when spraying described barrier, the insulation amount of particle about more than 1 times of common mouth mask or mouth mask adding distil water, and once intercepts rear residual particles amount below the half of common mouth mask.
7th embodiment
In 7th embodiment, provide a kind of method taking Candy for food as the form of the granule larynx sugar of carrier and fast and effeciently intercept, stop, suppress and eliminate that in air fine particle, harmful microorganism is invaded and harassed so that infected.In described method, composition DNA (deoxyribonucleic acid) gets Sodium deoxyribonucleate, adds and is furnished with antimicrobial, adds and is furnished with edible humectant adding ingredient, add and be furnished with fructose and pectin, adds and is furnished with edible saccharification and shaping composition.
In described embodiment, Sodium deoxyribonucleate content is greater than 0.08% and is less than 3.5%, antimicrobial agent content is greater than 0.01% and is less than 2.0%, and edible humectant adding ingredient content is greater than 2.0% and is less than 10.0%, more than add and be equipped with fructose and pectin and edible saccharification and shaping composition.
In described embodiment, Sodium deoxyribonucleate is taken from the refinement composition of fish, and molecular weight is at more than 30kDa, electronegative, there are vigor and the effect of very strong adsorption-condensation molecule, stop up for realizing sorption cohesion the Main Function composition pressing down fine particle and activity thereof; Add and be equipped with antimicrobial composition and be taken from natural animal-plant and refine composition, to kill in time once invade and contact the harmful microorganism of mucous membrane or intercept rapidly its breeding of interference and diffusion, effectively suppress harmful microorganism infection; Add and be equipped with edible humectant adding ingredient with stable and adjust the architectural characteristic of each composition, active state and environment, extend the iris action time, keep the affine state of best mucous membrane, and the effect making adhesion cohesion etc. intercept fine particles is strengthened.Fructose pectin is taken from natural fruit thing, can strengthen and stable adhered particles thing performance and regulate sweet taste mouthfeel.Add and be equipped with edible saccharification and the adjustable each composition active state of shaping composition and mouthfeel.
In described embodiment, adopt larynx sugar to suck the environment that mode can improve this barrier, significantly extend time and the action effect of action component release.Be particularly suitable for being inconvenient to use the pregnant woman of spray pattern and old young sufferer crowd to use.
Under the effect of described embodiment, fast and effeciently can intercept fine particle direct oral cavity in air to invade and interference, suppress and remove other comparable product numerous even the insoluble suction because of the harmful microorganism particle in air fine particle of medicine institute invades and harasses that the oral cavity and throat portion that causes is irritated, infection and other stiff reactions, for intercepting virus and bacteria and smog and suppressing it to have good effect to the stimulation of bottleneck throat.
8th embodiment
In 8th embodiment, provide a kind of with the form of artificial nose hair nasal obstruction intermediary for the care product of carrier property superposition unification, fast and effeciently intercept, stop, suppress and eliminate the method that in air, fine particle is invaded and harassed so that infected.In described method, composition DNA (deoxyribonucleic acid) gets Sodium deoxyribonucleate, adds and is furnished with humectant, adds and is furnished with antimicrobial, adds and is furnished with ethanol, adds and is furnished with water soluble chitosan or changes with pectin or change with the mixture of shitosan and pectin and Purified Water.Component ratio is by the proportioning of already described various embodiment.
In described embodiment, under the prerequisite not hindering nasal cavity eupnea, by executing the superposition of air filter on respiration channel in the nasal cavities such as the artificial nose hair nasal obstruction of this barrier, the obstruct to the harmful microorganism particle in intranasal air fine particle that can further improve this barrier, the effect suppressing and kill.
Just preferred embodiment of the present invention described in this specification, above embodiment is only in order to illustrate technical scheme of the present invention but not limitation of the present invention.All those skilled in the art, all should be within the scope of the present invention under this invention's idea by the available technical scheme of logical analysis, reasoning, or a limited experiment.
Claims (10)
1. suppress the barrier that in air fine particle, harmful microorganism infects, it is characterized in that, comprising: DNA (deoxyribonucleic acid), humectant and antimicrobial.
2. the barrier suppressing harmful microorganism infection in air fine particle as claimed in claim 1, it is characterized in that, described DNA (deoxyribonucleic acid) is Sodium deoxyribonucleate.
3. the barrier suppressing harmful microorganism infection in air fine particle as claimed in claim 1, it is characterized in that, described DNA (deoxyribonucleic acid), humectant and antimicrobial meet following weight ratio: 0.2%≤DNA (deoxyribonucleic acid)≤3.5%; 2.0%≤humectant≤20%; 0.01%≤antimicrobial≤2%.
4. the barrier suppressing harmful microorganism infection in air fine particle as claimed in claim 1, it is characterized in that, described barrier also comprises pectin, and described pectin meets following weight ratio: 0.05%≤pectin≤3.5%.
5. the barrier suppressing harmful microorganism infection in air fine particle as claimed in claim 1, it is characterized in that, described barrier also comprises water soluble chitosan, and described water soluble chitosan meets following weight ratio: 0.1%≤water soluble chitosan≤8%.
6. the barrier suppressing harmful microorganism infection in air fine particle as claimed in claim 1, it is characterized in that, described barrier also comprises ethanol, and described ethanol meets following weight ratio: 2.0%≤ethanol≤25%.
7. the barrier suppressing harmful microorganism infection in air fine particle as claimed in claim 1, it is characterized in that, described barrier also comprises butanediol, and described butanediol meets following weight ratio: 1.2%≤butanediol≤20%.
8. the barrier suppressing harmful microorganism infection in air fine particle as claimed in claim 1, it is characterized in that, described antimicrobial is the antimicrobial extracted from natural plants.
9. the barrier that in the suppression air fine particle as described in any one of claim 1 to 8, harmful microorganism infects, is characterized in that, described barrier is used for skin or mucomembranous surface.
10. the barrier that in the suppression air fine particle as described in any one of claim 1 to 8, harmful microorganism infects, it is characterized in that, described barrier is sprayed at oral cavity or nostril, or be attached to mouth mask with spraying or immersion liquid mode, nasal obstruction, air filtering are online, or directly spray in suffering in the air that harmful microorganism pollutes or body surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410504767.8A CN105494418B (en) | 2014-09-26 | 2014-09-26 | Barrier agent for inhibiting harmful microorganism infection in air fine particles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410504767.8A CN105494418B (en) | 2014-09-26 | 2014-09-26 | Barrier agent for inhibiting harmful microorganism infection in air fine particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105494418A true CN105494418A (en) | 2016-04-20 |
| CN105494418B CN105494418B (en) | 2020-08-07 |
Family
ID=55703031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410504767.8A Active CN105494418B (en) | 2014-09-26 | 2014-09-26 | Barrier agent for inhibiting harmful microorganism infection in air fine particles |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105494418B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101360546A (en) * | 2006-01-18 | 2009-02-04 | 日生生物股份有限公司 | Filtering device for air conditioner capable of removing harmful substance |
| CN102846655A (en) * | 2012-10-17 | 2013-01-02 | 天津工业大学 | Formulation and preparation method of antibacterial spray |
| CN103619341A (en) * | 2011-04-19 | 2014-03-05 | Arms制药有限公司 | Method of inhibiting harmful microorganisms and barrier-forming composition therefor |
-
2014
- 2014-09-26 CN CN201410504767.8A patent/CN105494418B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101360546A (en) * | 2006-01-18 | 2009-02-04 | 日生生物股份有限公司 | Filtering device for air conditioner capable of removing harmful substance |
| CN103619341A (en) * | 2011-04-19 | 2014-03-05 | Arms制药有限公司 | Method of inhibiting harmful microorganisms and barrier-forming composition therefor |
| CN102846655A (en) * | 2012-10-17 | 2013-01-02 | 天津工业大学 | Formulation and preparation method of antibacterial spray |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105494418B (en) | 2020-08-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6831227B2 (en) | Methods of Inhibiting Harmful Microorganisms and Barrier-Forming Compositions for them | |
| CN107970488A (en) | A kind of chitin quarternary ammonium salt aquagel antiseptic dressing and preparation method thereof | |
| CN103735581B (en) | Care solution for cleaning nasal cavity and preparation method of care solution | |
| CN106511473A (en) | Traditional Chinese medicine extracting solution capable of resisting bacteria, removing acnes and treating blebs as well as application thereof and skin-care lotion prepared from traditional Chinese medicine extracting solution | |
| JP5673560B2 (en) | Long-lasting bactericidal disinfectant | |
| CA2532555A1 (en) | Non-toxic mucosal disinfectant containing isopropyl alcohol, sesame oil, aloe, and lemon oil | |
| CN108371191A (en) | A kind of air antiseptic and its preparation method and application | |
| CN105963237B (en) | A kind of Novel mouthwash and its preparation method and application | |
| JP5467678B2 (en) | Pollen for masks, glasses and goggles, and anti-virus external preparation | |
| JP2020525526A (en) | Antiviral and antibacterial composition for eyes, oral cavity, nasal cavity or inhalation containing a solid composition containing an iodine agent and sodium chloride with improved water solubility and an aqueous solution thereof | |
| CN104798823A (en) | Bactericide for clinical laboratory | |
| CN105920094A (en) | Nasal cavity nursing composition, application thereof and obtained nasal cavity nursing product | |
| CN104094979B (en) | Application of the Folium Salicis Babylonicae in disinfectant is prepared | |
| CN110433130A (en) | A kind of male's basic nursing liquid | |
| CN106420938B (en) | A kind of Chinese medicine composition and preparation method thereof for treating oral inflammation and pharyngitis | |
| CN105494418A (en) | Blocking agent for inhibiting infection of harmful microbes in fine particles in air | |
| CN108939145A (en) | A kind of liquid adhesive bandage and preparation method thereof | |
| CN104338168A (en) | Air freshener for upper respiratory infection patients and preparing method thereof | |
| CN110638910B (en) | A breath freshener with antiviral, antibacterial and antiinflammatory effects, and its preparation method | |
| CN107485584A (en) | A kind of oral care composition | |
| WO2021258654A1 (en) | Silver ion antibacterial hand sanitizer, preparation method therefor, and application thereof | |
| CN112826849A (en) | Compound traditional Chinese medicine with broad-spectrum antibacterial, anti-inflammatory and antiviral effects and preparation method thereof | |
| CN105497056B (en) | Barrier agent for inhibiting fine air particles from invading human body | |
| CN106691932A (en) | Mosquito-repelling floral water and preparation method thereof | |
| CN103977081B (en) | A kind of oropharynx is antibacterial and improve the compositions of oropharynx immunity and preparation thereof and purposes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |