CN105491997B - 舌下及颊面膜组合物 - Google Patents

舌下及颊面膜组合物 Download PDF

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Publication number
CN105491997B
CN105491997B CN201480027179.8A CN201480027179A CN105491997B CN 105491997 B CN105491997 B CN 105491997B CN 201480027179 A CN201480027179 A CN 201480027179A CN 105491997 B CN105491997 B CN 105491997B
Authority
CN
China
Prior art keywords
film dosage
film
dosage composition
agonist
naloxone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201480027179.8A
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English (en)
Chinese (zh)
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CN105491997A (zh
Inventor
G·L·迈尔斯
E·戴迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aquitif Therapy Co
Original Assignee
Aquitif Therapy Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Aquitif Therapy Co filed Critical Aquitif Therapy Co
Publication of CN105491997A publication Critical patent/CN105491997A/zh
Application granted granted Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201480027179.8A 2013-03-15 2014-03-14 舌下及颊面膜组合物 Active CN105491997B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13/842,543 2013-03-15
US13/842,543 US20140271788A1 (en) 2013-03-15 2013-03-15 Sublingual and buccal film compositions
US14/196,082 2014-03-04
US14/196,082 US9511033B2 (en) 2013-03-15 2014-03-04 Sublingual and buccal film compositions
PCT/US2014/028568 WO2014144241A1 (en) 2013-03-15 2014-03-14 Sublingual and buccal film compositions

Publications (2)

Publication Number Publication Date
CN105491997A CN105491997A (zh) 2016-04-13
CN105491997B true CN105491997B (zh) 2019-12-17

Family

ID=51528033

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480027179.8A Active CN105491997B (zh) 2013-03-15 2014-03-14 舌下及颊面膜组合物

Country Status (15)

Country Link
US (5) US20140271788A1 (enExample)
EP (1) EP2968121B1 (enExample)
JP (2) JP6448096B2 (enExample)
KR (1) KR20160029730A (enExample)
CN (1) CN105491997B (enExample)
AU (1) AU2014227693B2 (enExample)
BR (1) BR112015023725A2 (enExample)
CA (1) CA2906773C (enExample)
DK (1) DK2968121T3 (enExample)
IL (1) IL241441B (enExample)
MX (1) MX2015013184A (enExample)
MY (1) MY181159A (enExample)
RU (1) RU2015143647A (enExample)
WO (1) WO2014144241A1 (enExample)
ZA (1) ZA201507685B (enExample)

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US20140271788A1 (en) * 2013-03-15 2014-09-18 Monosol Rx, Llc Sublingual and buccal film compositions
AU2015341490C1 (en) 2014-11-07 2021-03-11 Indivior Uk Limited Buprenorphine dosing regimens
US20160175296A1 (en) * 2014-12-23 2016-06-23 Arx, Llc Method of producing uniform buprenorphine-containing formulations
EP3281625B1 (en) * 2015-04-07 2020-02-26 Nipro Corporation Oral film preparation
KR102851614B1 (ko) 2016-02-04 2025-08-29 신돔 파마, 인크. 장애 치료를 위한 중수소화된 돔페리돈 조성물 및 방법
US11738036B2 (en) 2016-05-28 2023-08-29 Rajiv Gandhi Centre For Biotechnology, An Autonomous Institute Under The Department Of Biotechnology, Government Of India Uttroside B and derivatives thereof as therapeutics for hepatocellular carcinoma
JP2020500220A (ja) 2016-11-15 2020-01-09 クラリア ファーマ ホールディング エービー 医薬製剤
CA3045043A1 (en) 2016-12-31 2018-07-05 Bioxcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
GB201709141D0 (en) 2017-06-08 2017-07-26 Klaria Pharma Holding Ab Pharmaceutical formulation
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
KR20240125702A (ko) 2017-06-30 2024-08-19 신돔 파마, 인크. 중수소화 돔페리돈 조성물, 방법, 및 제조
US12478612B2 (en) 2017-06-30 2025-11-25 Cindome Pharma, Inc. Deuterated domperidone compositions, methods, and preparation
EP3473246A1 (en) 2017-10-19 2019-04-24 Capsugel Belgium NV Immediate release abuse deterrent formulations
GB201808462D0 (en) 2018-05-23 2018-07-11 Klaria Pharma Holding Ab Pharmaceutical formulation
WO2019240212A1 (ja) * 2018-06-14 2019-12-19 株式会社カネカ 薬学的活性成分を含む製剤
CN115154440A (zh) 2018-06-27 2022-10-11 比奥克斯塞尔医疗股份有限公司 含右美托咪定的膜制剂及其制造方法
US11648197B2 (en) * 2018-06-28 2023-05-16 Arx, Llc Dispensing method for producing dissolvable unit dose film constructs
GB201819978D0 (en) * 2018-12-11 2019-01-23 Univ Strathclyde Oral thin films
JP7287032B2 (ja) 2019-03-20 2023-06-06 株式会社リコー シート、シート積層体、医薬品、シートの製造方法、及びシート積層体の製造方法
WO2021016112A2 (en) 2019-07-19 2021-01-28 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
US11806320B2 (en) * 2020-02-19 2023-11-07 Endo Ventures Limited Isoproterenol compositions and methods
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
WO2025147530A1 (en) * 2024-01-05 2025-07-10 Taho Pharmaceuticals Ltd. Naloxone buccal film product and uses thereof

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WO2005117838A1 (en) * 2004-06-02 2005-12-15 Galephar M/F Stable oral pharmaceutical compositions of buprenorphine and derivatives
CN102481250A (zh) * 2009-08-07 2012-05-30 莫诺索尔克斯有限公司 舌下和口腔膜组合物
CN102548535A (zh) * 2009-08-07 2012-07-04 雷克特本克斯尔保健(英国)有限公司 舌下和口腔用薄膜组合物

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ATE214276T1 (de) 1994-09-19 2002-03-15 Du Pont Pharm Co Zusammensetzungen von opioid antagonisten mit selektiven serotonin-aufnahme inhibitoren, zur behandlung von alkoholismus und alkohoabhängigkeit
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AT403162B (de) 1995-10-11 1997-11-25 Nycomed Austria Gmbh Neue kristallform von morphin-6-glucuronid
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PT914097E (pt) 1996-03-12 2002-06-28 Alza Corp Composicao e forma de dosagem compreendendo antagonista de opioide
WO1998035679A1 (de) 1997-02-14 1998-08-20 Gödecke Aktiengesellschaft Stabilisierung von naloxonhydrochlorid
KR100514963B1 (ko) 1997-07-11 2005-09-15 도레이 가부시끼가이샤 4,5-에폭시모르피난 유도체를 함유하는 안정한 의약품 조성물
ATE210983T1 (de) 1997-11-03 2002-01-15 Stada Arzneimittel Ag Stabilisiertes kombinationsarzneimittel enthaltend naloxone und ein opiatanalgetikum
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Publication number Priority date Publication date Assignee Title
WO2005117838A1 (en) * 2004-06-02 2005-12-15 Galephar M/F Stable oral pharmaceutical compositions of buprenorphine and derivatives
CN102481250A (zh) * 2009-08-07 2012-05-30 莫诺索尔克斯有限公司 舌下和口腔膜组合物
CN102548535A (zh) * 2009-08-07 2012-07-04 雷克特本克斯尔保健(英国)有限公司 舌下和口腔用薄膜组合物

Also Published As

Publication number Publication date
RU2015143647A (ru) 2017-04-21
IL241441B (en) 2019-07-31
EP2968121A1 (en) 2016-01-20
US20140271788A1 (en) 2014-09-18
JP6448096B2 (ja) 2019-01-09
CN105491997A (zh) 2016-04-13
IL241441A0 (en) 2015-11-30
WO2014144241A1 (en) 2014-09-18
KR20160029730A (ko) 2016-03-15
CA2906773C (en) 2023-12-12
US20200315984A1 (en) 2020-10-08
AU2014227693A1 (en) 2015-10-29
US9511033B2 (en) 2016-12-06
MY181159A (en) 2020-12-19
BR112015023725A2 (pt) 2017-07-18
DK2968121T3 (en) 2019-02-04
AU2014227693B2 (en) 2018-06-21
MX2015013184A (es) 2016-04-07
ZA201507685B (en) 2017-06-28
EP2968121B1 (en) 2018-12-19
US20170296482A1 (en) 2017-10-19
US20140271789A1 (en) 2014-09-18
JP2019048882A (ja) 2019-03-28
CA2906773A1 (en) 2014-09-18
US20190038570A1 (en) 2019-02-07
JP2016513736A (ja) 2016-05-16

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Applicant after: Aquitif Therapy Company

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Applicant before: MONOSOL RX LLC

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