CN105476998A - Application of hexamethylenetetramine to preparation of antiviral medicines - Google Patents
Application of hexamethylenetetramine to preparation of antiviral medicines Download PDFInfo
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- CN105476998A CN105476998A CN201510850972.4A CN201510850972A CN105476998A CN 105476998 A CN105476998 A CN 105476998A CN 201510850972 A CN201510850972 A CN 201510850972A CN 105476998 A CN105476998 A CN 105476998A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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Abstract
The invention provides application of hexamethylenetetramine to preparation of antiviral medicines and particularly provides application of hexamethylenetetramine to preparation of medicines for treating influenza, Newcastle disease, infectious bronchitis, swine fever and the like. According to animal experiments, the medicines with hexamethylenetetramine serving as an active ingredient have excellent treatment effects on diseases including influenza, Newcastle disease, infectious bronchitis, swine fever and the like caused by viruses and have high practical value in the field of medicines and the field of veterinary medicines.
Description
Technical field
The invention belongs to hexamethylenetetramine applied technical field, be specifically related to the new opplication of a kind of hexamethylenetetramine in preparation antiviral drugs.
Background technology
Hexamethylenetetramine (having another name called hexamethylenamine) is a kind of classical inexpensive drugs for the treatment of urinary tract bacteriological infection.Because hexamethylenetetramine has antibacterial action, therefore external also has certain therapeutical effect to bromhidrosis, foot odor, fetid sweat.
Viral infection is the common susceptible disease of humans and animals, serious harm human health and animal farming industry.Applicant studies discovery: hexamethylenetetramine also has the effect of the disease that the viral infection such as treatment influenza, flu, fowl newcastle, infectious bronchitis, swine fever cause.
Although patent application (CN1242195A) openly reports the bacillary merging viral infection of compound preparation to chicken that hexamethylenetetramine and moroxydine, sodium camphorsulfonate, sodium chloride, potassium chloride, calcium chloride forms good therapeutical effect.But those skilled in the art can think that the effect of hexamethylenetetramine in this compound preparation is antibacterial action mostly.Because hexamethylenetetramine is antimicrobial component unique in this compound preparation, and moroxydine is antiviral composition.In addition, this patent application does not point out or has experimental data to show hexamethylenetetramine have other ingredient combination in the effect or hexamethylenetetramine and compound preparation of independently treating viral infection to use the effect having and treat viral infection, and do not point out that this compound preparation is viral and bacillary concurrent infection is effective to which kind of yet, do not provide the dosage determined yet.Hexamethylenetetramine has the therapeutical effect to viral infection, and namely antivirus action is not yet disclosed at present and reported.The application studies proof: hexamethylenetetramine can be used for preparing in the medicine for the treatment of human or animal viral infection.At present, at animal farming industry, not used for the legal chemicals that treatment animal viral infects, mostly only have Chinese medicine, the present invention is expected to address this problem.
Summary of the invention
The object of the invention is to overcome prior art defect, provides the new opplication of a kind of hexamethylenetetramine in preparation antiviral drugs.
For achieving the above object, the present invention adopts following technical scheme:
The invention provides the application of hexamethylenetetramine in preparation human or animal antiviral drugs, the i.e. application of hexamethylenetetramine in the medicine of preparation treatment disease of viral infection, be equivalent to a kind of novelty teabag having found hexamethylenetetramine, to expand the range of application of hexamethylenetetramine.
Concrete, above-mentioned application can be the application of hexamethylenetetramine in preparation human or animal Tamiflu, and namely disease of viral infection can be the influenza of human or animal.
Preferably, the application in the above-mentioned application cold medicine that can be hexamethylenetetramine cause at preparation human or animal antiviral, the application namely in the medicine for the preparation for the treatment of human or animal viral influenza.
Concrete, above-mentioned application can be the application of hexamethylenetetramine in preparation treatment fowl newcastle disease virus infection medicine.
Concrete, above-mentioned application can also be the application of hexamethylenetetramine in preparation treatment human or animal infectious bronchitis medicine, the application especially in the viral infection bronchitis medicine for the preparation for the treatment of human or animal.
Concrete, above-mentioned application can also be the application of hexamethylenetetramine in the anti-swine fever medicine of preparation, the application namely in the medicine of the infection caused for the preparation for the treatment of swine fever virus.
In addition, the invention provides hexamethylenetetramine and coordinate the application of other medicines in preparation treatment viral infectious diseases.
Above-mentioned antiviral drugs can be by hexamethylenetetramine as active component and conventional pharmaceutical adjuvants composite after, the oral tablet made according to a conventional method, oral liquid, capsule, granule, powder, soluble powder, injection or spray etc.
The application verifies through animal clinical study: the infection that hexamethylenetetramine infected by influenza, cold virus, infectious bronchitis virus, birds Avian pneumo-encephalitis virus, swine fever virus are caused has significant therapeutic effect.
Compared to the prior art, the invention has the advantages that:
1) application of hexamethylenetetramine in preparation treatment disease of viral infection medicine is provided.By zoopery, the present invention confirms that hexamethylenetetramine has the effect for the treatment of viral infectious diseases, and curative effect is very remarkable, with low cost, safety is good, show hexamethylenetetramine can as treatment disease of viral infection active drug, for clinical treatment viral infectious diseases provides a kind of new departure;
2) the present invention is expected to solve the problem that animal farming industry is not specifically designed to the chemicals for the treatment of viral infectious diseases, and contribution has been made in the sound development for animal farming industry;
3) can be made into oral, injection and other parenteral administration dosage form.As passed through the form administrations such as oral tablet, capsule, oral liquid, granule, powder, solubilized powder, injection, spray.
Detailed description of the invention
Do to introduce in detail further to technical scheme of the present invention below in conjunction with embodiment, but protection scope of the present invention is not limited thereto.
Embodiment 1: influenza is tested
1, experiment material
1. raw material hexamethylenetetramine, ribavirin (virazole) are provided by Taide, Hebi biochemical technology company limited, lot number 20152008;
2. Influenza A1 virus FM1, Mus lung adapted strain, is identified by Chinese pharmaceutical biological product and provided, and after mice enhancing virulence, to go down to posterity secondary, and measure its median lethal dose(LD 50) LD50 in Embryo Gallus domesticus blister cavities;
3. MC-3B type computer numeral formula clinical thermometer, capacity measurer is made by oneself;
4. NIH mice, is provided by Zhengzhou University's animal center;
5. experimental data represents with mean standard deviation, compares and adopt t inspection between group.
2, method and result
Get seed culture of viruses physiological saline solution before experiment and be diluted to every 0.05ml containing 10 LD50, put in refrigerator and preserve.Get NIH mice, body weight 13-15g, male and female half and half, be divided at random 3 groups (i.e. virus control, ribavirin group and hexamethylenetetramine groups), often organize 20.Under ether light anesthesia, infect with influenza virus drop nose, every Mus four, altogether about 0.05ml.Administration group (i.e. ribavirin group and hexamethylenetetramine group) starts gastric infusion in viral infection the previous day, and virus control group gives corresponding distilled water, every day 1 time, continuous 10 days.Day by day observe animal disease symptom and death toll, observe 15 days altogether.The results are shown in following table 1.
Table 1. hexamethylenetetramine group is on the impact of Influenza A1 virus infecting mouse mortality rate
Note: compare * P < 0.05 with virus control group.
As can be seen from table: time-to-live of hexamethylenetetramine group mice, survival rate are all higher than ribavirin group.
Embodiment 2: to the treatment of bird flu
850 195 age in days laying hens are raised on a household basis in the poultry of Luyi County, Henan Province, state morbidity on March 16th, 2013, symptom: body temperature rising, dyspnea, lethargy, loss of appetite or useless exhausted, dipsa increase, head is swollen, eye has secretions increase, egg production sharply declines, and even occurs death.According to epidemiology, clinical symptoms with analyse pathological changes, be diagnosed as bird flu.
Treatment: with 200mg/L hexamethylenetetramine aqueous solution whole day drinking water administration, medication after 1 day the state of an illness greatly take a turn for the better, within 2 days, cure 830 afterwards, take a turn for the better 12, effective percentage 99%.Wherein, cure the clinical symptom disappearance meaning chicken, feed intake, feces, mental restoration are normal, and egg production recovers normal; Improvement means clinical symptom relief, feed intake, feces, spiritual normal, egg production rise.
Embodiment 3: to the treatment of newcastle disease
Henan Province's in October, 2012 Taikang County one raiser raises more than the 1000 only 181 blue brown laying hen morbidities in age in days sea.Chicken group spirit is depressed, laxativeness, minority mouth breathing, and the number of soft egg and husky egg significantly increases.Diagnose this disease for atypical newcastle disease according to incidence, clinical symptoms, pathological change and laboratory examination results.
Treatment: with 200mg/L hexamethylenetetramine aqueous solution whole day drinking water administration, after 1 day, sb.'s illness took a favorable turn, cures 95% after 3 days.Cure and mean clinical symptom disappearance, feces, spirit, feed intake, egg production recover normal; Improvement means that spirit, diet, feces recover normal substantially, and the clinical symptoms such as diarrhoea obviously alleviate, and laying rate is gone up.
Embodiment 4: to the treatment of infectious bronchitis
5000 Roman egghen that poultry family, Luyi County, Henan Province in 2010 is raised are opening morbidity in about 3 weeks puerperal, sickness rate 35%, and symptom is cough, sneeze, trachea generation rale, and egg production declines, and part soft-preserved egg and abnormal-shape egg, kidney enlargement is pale.According to incidence, clinical manifestation and pathological change etc., be diagnosed as Nephropathogenic infectious bronchitis.
Infectious bronchitis is the chicken respiratory infectious disease that infectious bronchitis virus causes.By 1750 of diagnosis sick chicken isolation, feed the hexamethylenetetramine aqueous solution of drink 200mg/L, be used in conjunction 3 days.Result cures 95.1%, takes a turn for the better 3.5%.Wherein cure and mean that spiritual appetite recovers normal, other clinical symptom disappearance, egg production is recovered; Improvement means that spirit takes a turn for the better, clinical symptom relief, and appetite increases.
Embodiment 5: to the treatment of mild swine fever
Since 2010, select treatment mild swine fever 256 on different pig farm altogether, cured 211, cure rate 82.4%, take a turn for the better 29, account for 11.3%, always have rate 93.7%.Therapeutic Method feeds drink 200mg/L hexamethylenetetramine aqueous solution to affected pig, is used in conjunction 3-5 days.Wherein, cure and mean that body temperature is down to normal range, appetite increases, feces is normal again, and do not occur repeatedly; Improvement means temperature decline, but still less than normal range, have appetite or appetite to increase, feces is often answered substantially, and after drug withdrawal, the state of an illness no longer worsens.
Embodiment 6: to the treatment of cold pig
In January, 2008-April, choosing was caught a cold wean pig 121, weight average 13.5kg/ head, and age in days is 25-35 day on large-scale pig farm, Henan Luyi County, and symptom is that body temperature raises, cough, photophobia sheds tears and rhinorrhea, and appetite declines, and is cold pig through Disease Diagnosis of Veterinary.
Treatment: with the treatment of 200mg/L hexamethylenetetramine aqueous solution drinking-water, whole day administration, successive administration 3 days, cure rate 90.2%, effective percentage 5.1%.Cure and mean that medication is after 3 days, Symptoms recovers normal, spirit, searches for food, drinks water and breathes normally; Effectively mean that medication is after 3 days, Symptoms is normal, spirit, searches for food, drinks water, breathes improvement.
Claims (7)
1. the application of hexamethylenetetramine in preparation human or animal antiviral drugs.
2. application according to claim 1, is characterized in that, the application of hexamethylenetetramine in preparation human or animal Tamiflu.
3. application according to claim 1, is characterized in that, the application in the cold medicine that hexamethylenetetramine causes at preparation human or animal antiviral.
4. application according to claim 1, is characterized in that, the application of hexamethylenetetramine in preparation treatment fowl newcastle disease virus infection medicine.
5. application according to claim 1, is characterized in that, the application of hexamethylenetetramine in preparation treatment human or animal infectious bronchitis medicine.
6. application according to claim 1, is characterized in that, the application of hexamethylenetetramine in the anti-swine fever medicine of preparation.
7. according to the arbitrary described application of claim 1 to 6, it is characterized in that, described antiviral drugs be by hexamethylenetetramine as active component and conventional pharmaceutical adjuvants composite after, the oral tablet made according to a conventional method, oral liquid, capsule, granule, powder, soluble powder, injection or spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510850972.4A CN105476998A (en) | 2015-11-30 | 2015-11-30 | Application of hexamethylenetetramine to preparation of antiviral medicines |
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| CN201510850972.4A CN105476998A (en) | 2015-11-30 | 2015-11-30 | Application of hexamethylenetetramine to preparation of antiviral medicines |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0425840A2 (en) * | 1989-10-31 | 1991-05-08 | Jaeger, Karl-Heinz, Dr. med. | Use of methenamine in the treatment of viral diseases and malign neoplasies |
| RU2163121C1 (en) * | 2000-05-30 | 2001-02-20 | Государственное унитарное предприятие Межбольничная аптека Медицинского центра Управления делами Президента Российской Федерации | Anticold agent |
-
2015
- 2015-11-30 CN CN201510850972.4A patent/CN105476998A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0425840A2 (en) * | 1989-10-31 | 1991-05-08 | Jaeger, Karl-Heinz, Dr. med. | Use of methenamine in the treatment of viral diseases and malign neoplasies |
| RU2163121C1 (en) * | 2000-05-30 | 2001-02-20 | Государственное унитарное предприятие Межбольничная аптека Медицинского центра Управления делами Президента Российской Федерации | Anticold agent |
Non-Patent Citations (3)
| Title |
|---|
| 叶夫根尼.谢利科瓦: "流感和急性呼吸道病毒感染防治", 《实用预防医学》 * |
| 杨君宜: "猪霉菌毒素中毒继发猪瘟的诊治报告", 《畜禽业》 * |
| 许良等: "乌洛托品治疗鸡肾型传染性支气管炎效果好", 《养禽与禽病防治》 * |
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Application publication date: 20160413 |
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