CN105473141A - 治疗和/或预防心血管疾病的抗pcsk9化合物和方法 - Google Patents

治疗和/或预防心血管疾病的抗pcsk9化合物和方法 Download PDF

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CN105473141A
CN105473141A CN201480016207.6A CN201480016207A CN105473141A CN 105473141 A CN105473141 A CN 105473141A CN 201480016207 A CN201480016207 A CN 201480016207A CN 105473141 A CN105473141 A CN 105473141A
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amino
alkyl
heterocycle
aryl
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谢林·萨拉赫丁·阿卜杜勒-马吉德
马吉德·阿布-阿布扎比
本杰明·布拉斯
韦恩·奇尔德斯
纳比勒·艾尔斯霍尔巴吉
维克托·吉杜
罗杰利奥·马丁内斯
哈罗德·迈耶斯
沙克尔·A·穆萨
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Temple Univ School of Medicine
Shifa Biomedical Corp
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Temple Univ School of Medicine
Shifa Biomedical Corp
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CN113166101A (zh) * 2018-11-27 2021-07-23 诺华股份有限公司 作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂的环状五聚体化合物
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US12282014B2 (en) 2015-11-19 2025-04-22 Dana-Farber Cancer Institute, Inc. Methods of identifying compounds that interfere with ERG-driven misguidance of BAF complexes in TMPRSS2-ERG driven prostate cancers
CN108239073A (zh) * 2016-12-23 2018-07-03 财团法人生物技术开发中心 化合物、医药组成物及其用途
CN112153984A (zh) * 2018-01-30 2020-12-29 福宏治疗公司 化合物及其用途
US11497752B2 (en) 2018-01-30 2022-11-15 Foghorn Therapeutics Inc. Compounds and uses thereof
US12383560B2 (en) 2018-01-30 2025-08-12 Foghorn Therapeutics Inc. Compounds and uses thereof
US12473334B2 (en) 2018-10-17 2025-11-18 Dana-Farber Cancer Institute, Inc. SWI/SNF family chromatin remodeling complexes and uses thereof
CN113166101A (zh) * 2018-11-27 2021-07-23 诺华股份有限公司 作为治疗代谢障碍的蛋白质原转换酶枯草杆菌蛋白酶/kexin 9型（PCSK9）抑制剂的环状五聚体化合物
US12486262B2 (en) 2020-01-29 2025-12-02 Foghorn Therapeutics Inc. Compounds and uses thereof
US12509453B2 (en) 2020-01-29 2025-12-30 Foghorn Therapeutics Inc. BRM/BRG1 inhibitors and uses thereof
US12383555B2 (en) 2020-05-20 2025-08-12 Foghorn Therapeutics Inc. Methods of treating cancers

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