CN105470098B - Ion-trap time-of-flight mass spectrometer method to set up based on magnetic field - Google Patents
Ion-trap time-of-flight mass spectrometer method to set up based on magnetic field Download PDFInfo
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- CN105470098B CN105470098B CN201511020353.9A CN201511020353A CN105470098B CN 105470098 B CN105470098 B CN 105470098B CN 201511020353 A CN201511020353 A CN 201511020353A CN 105470098 B CN105470098 B CN 105470098B
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/40—Time-of-flight spectrometers
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- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
A kind of ion-trap time-of-flight mass spectrometer method to set up based on magnetic field, occurs module, ion using ion gun and introduces and screening module, ion trap module, flight disk module, detector module；After the sample ionization that the ion source module is introduced into, after focusing on or screen through ion focusing screening module, into the enrichment of ion trap module, ion space position reset, import the flight disk module in even strong Lorentz magnetic field, the number of turns of ion flight is controlled, and ion is reached detector completion signal detection；Flight disk module is to set Lorentz magnetic field on ion flight track, and the flight that ion is controlled by Lorentz magnetic field is circuit orbit, and controls the flight number of turns of ion, and counter ion reaches that the time of detector is qualitative come ion of advancing.
Description
Technical field
The invention belongs to chemical analysis instrument technical field, and in particular to a kind of ion trap flight time matter based on magnetic field
Spectrometer, available for the qualitative of chemical substance and quantitatively.
Background technology
It is highly 1-1.5 meters because current time of-flight mass spectrometer uses the tof tube perpendicular to instrument, interior added electric field
Control motion of the ion in (application electric field) tof tube.Time of-flight mass spectrometer in order to obtain higher resolution ratio, it is necessary to plus
The length of the altitude pipe of long tof tube, which increase occupancy of the instrument to lab space, and gives up space and seeks instrument
The direction of performance not Instrument Development.
The content of the invention
It is originally towering in matter present invention aims at there is provided a kind of ion-trap time-of-flight mass spectrometer based on magnetic field, making
The tof tube of spectrometer replaces with the flight disk placed oneself in the midst of within mass spectrograph.Taken up space except saving instrument, by controlling ion
The flight number of turns can reach conventional flight pipe identical resolution requirement in flight disk.
A kind of ion-trap time-of-flight mass spectrometer method to set up based on magnetic field, including ion gun occur module, ion and drawn
Enter and screening module, ion trap module, flight disk module, detector module；The sample ions that the ion source module is introduced into
After change, after focusing on or screen through ion focusing screening module, into the enrichment of ion trap module, ion space position reset, lead
Enter to be in the flight disk module of uniform magnetic field, control the number of turns of ion flight, and ion is reached detector and complete signal
Detection.
Its ion source module can be electron spray ionisation or Matrix Assisted Laser Desorption ionization source.Make analyte ions.
Flight disk module is to set Lorentz magnetic field on ion flight track, and flying for ion is controlled by Lorentz magnetic field
Behavior circuit orbit, and the flight number of turns of ion is controlled, counter ion reaches that the time of detector is qualitative come ion of advancing.This hair
The bright introducing by flight disk and save instrument space.On the Radius of circuit orbit, electric field is provided with perpendicular to radius,
Accelerate that after ion ion trajectory circumference can expand, for accelerating ion, the resolution ratio of ion can be controlled.
Its structure composition includes ion source module, ion and introduced and screening module, ion trap module, flight disk module, inspection
Survey device module.
Ion is introduced and analyte ions are focused on and introduce ion channel by screening module, will according to user by level Four bar
Ask and decide whether to open ion screening function.Introduce and screening function is completed by ion lens (electric field lens) or capillary, sieve
Function is selected to be completed by level Four bar.
The ion that ion trap module is characterised by being introduced into or screened is enriched with, and is perpendicular by the ion compression of enrichment
Straight ion band.Make it have identical flight position, and give a constant kinetic energy and dish out ion trap.
Flight disk module has uniform magnetic field in being characterised by, the ion into magnetic field can be made to do uniform circular motion, and
Control its number of turns flown in magnetic field.Finally ion is set to reach detector.
Beneficial effect：The present invention provides a kind of ion-trap time-of-flight mass spectrometer based on magnetic field, passes through Lorentz magnetic field
Ion flight is controlled, makes script is towering to replace with the circular flight disk placed oneself in the midst of within mass spectrograph in mass spectrometric tof tube.Section
Save instrument to be taken up space, by controlling ion flight number of turns in flight disk to reach, conventional flight pipe identical resolution ratio will
Ask.
Brief description of the drawings
Fig. 1 is block diagram of the present invention.
Embodiment
Such scheme is described further below in conjunction with specific embodiment.It should be understood that these embodiments are to be used to illustrate
The present invention and be not limited to limit the scope of the present invention.The implementation condition used in embodiment can be done according to the condition of specific producer
Further adjustment, unreceipted implementation condition is usually the condition in normal experiment.
Shown in case study on implementation, ion gun can be electron spray ionisation or Matrix Assisted Laser Desorption ionization source, make analyte from
Sonization, analyte ions are focused on introduce ion channel by electric field and vacuum gradient, by level Four bar, ion can be allowed all logical
Cross or carry out ion screening.The ion come from level Four bar is enriched with by ion trap, and is vertical by the ion compression of enrichment
Ion band, make it have identical flight position.Give one uniform electric field of ion of enrichment, ion trap of being dished out, institute
There is ion to obtain identical kinetic energy.Ion enters flight disk, and the ion of smaller quality has faster speed.Flight disk module is
One vertical circle box body, the coil of circle box body periphery (a diameter of 0.8-1.5m of circle box body) coiling 10-30 circles is used to apply straight
Electric current is flowed, the flight that ion is controlled by Lorentz magnetic field is circuit orbit, and controls the flight number of turns of ion, and counter ion reaches
Ion of being advanced to the time of detector is qualitative.(parallel to horizontal plane direction) on the Radius of circle box body, perpendicular to this partly
Footpath is used to apply electric field provided with a pair of parallel metal electrode, and electric field accelerates that after ion ion trajectory circumference can expand every time
Greatly, for accelerating ion, the path that circumference expands is that ion stream is drawn at tangent line, and the number of turns for controlling it to be flown in magnetic field,
Make the run duration difference amplification of the ion of each different mass-to-charge ratio, finally ion is reached detector.Ion can be controlled
Resolution ratio.
It will be appreciated by those skilled in the art that accompanying drawing is the schematic diagram of a preferred embodiment, and this hair is limited without one
Bright, within the spirit and principles of the invention, any modification, equivalent substitution, simple modifications for being made etc. should be included in this
Within the protection domain of invention.
Claims (2)
1. a kind of ion-trap time-of-flight mass spectrometer method to set up based on magnetic field, it is characterized in that using ion gun occur module,
Ion is introduced and screening module, ion trap module, flight disk module, detector module；The ion gun occurs module and is introduced into
Sample ionization after, through ion introduce and screening module focus on or screen after, into ion trap module enrichment, ion space
Position reset, imports the flight disk module in even strong Lorentz magnetic field, controls the number of turns of ion flight, and finally arrives ion
Signal detection is completed up to detector；
Flight disk module is to set Lorentz magnetic field on ion flight track, and the flight for controlling ion by Lorentz magnetic field is
Circuit orbit, and the flight number of turns of ion is controlled, counter ion reaches that the time of detector is qualitative come ion of advancing；
Electric field is provided with the Radius of circuit orbit, and perpendicular to radius, accelerates to expand ion trajectory circumference after ion,
For accelerating ion；
It is electron spray ionisation or Matrix Assisted Laser Desorption ionization source that module, which occurs, for the ion gun, makes analyte ions；
Ion is introduced and analyte ions are focused on and introduce ion channel by screening module, by level Four bar, is required to determine according to user
It is fixed whether to open ion screening function；
Flight disk module is a vertical circle box body, and the coil of circle box body periphery coiling 10-30 circles is used to apply DC current,
The a diameter of 0.8-1.5m of circle box body；Circle box body parallel on the Radius of horizontal plane direction be provided with a pair of parallel metal electrode
For applying electric field.
2. the ion-trap time-of-flight mass spectrometer method to set up according to claim 1 based on magnetic field, it is characterized in that ion
The ion that trap module is introduced into or screened is enriched with, and is vertical ion band by the ion compression of enrichment；Make it have phase
With flight position, and give a constant kinetic energy and dish out ion trap.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511020353.9A CN105470098B (en) | 2015-12-30 | 2015-12-30 | Ion-trap time-of-flight mass spectrometer method to set up based on magnetic field |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511020353.9A CN105470098B (en) | 2015-12-30 | 2015-12-30 | Ion-trap time-of-flight mass spectrometer method to set up based on magnetic field |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105470098A CN105470098A (en) | 2016-04-06 |
| CN105470098B true CN105470098B (en) | 2017-09-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201511020353.9A Active CN105470098B (en) | 2015-12-30 | 2015-12-30 | Ion-trap time-of-flight mass spectrometer method to set up based on magnetic field |
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Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4645424B2 (en) * | 2005-11-24 | 2011-03-09 | 株式会社島津製作所 | Time-of-flight mass spectrometer |
| JP2007194094A (en) * | 2006-01-20 | 2007-08-02 | Shimadzu Corp | Mass spectroscope |
| JP2011146180A (en) * | 2010-01-13 | 2011-07-28 | Shimadzu Corp | Time-of-flight mass spectrometer |
| CN102800553B (en) * | 2012-09-02 | 2015-07-29 | 王利兵 | A kind of gas phase liquid chromatogram-electronics bombardment electron spray dual ion source flight time mass spectrum system |
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