CN105457020A - 肿瘤液化的方法和组合物 - Google Patents

肿瘤液化的方法和组合物 Download PDF

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Publication number
CN105457020A
CN105457020A CN201510883465.0A CN201510883465A CN105457020A CN 105457020 A CN105457020 A CN 105457020A CN 201510883465 A CN201510883465 A CN 201510883465A CN 105457020 A CN105457020 A CN 105457020A
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cell
purposes according
tumor
patient
cancer
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Chinese (zh)
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迈克尔·哈-诺伊
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Immunovative Therapies Ltd
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Immunovative Therapies Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/191Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/193Colony stimulating factors [CSF]
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
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    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • AHUMAN NECESSITIES
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    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613Irreversible electroporation
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5154Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
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    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55516Proteins; Peptides
    • AHUMAN NECESSITIES
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    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
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    • A61K2039/55533IL-2
    • AHUMAN NECESSITIES
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    • A61K2039/55538IL-12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/26Universal/off- the- shelf cellular immunotherapy; Allogenic cells or means to avoid rejection
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    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201510883465.0A 2009-12-15 2010-12-15 肿瘤液化的方法和组合物 Pending CN105457020A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28655109P 2009-12-15 2009-12-15
US61/286,551 2009-12-15
US12/967,910 2010-12-14
US12/967,910 US20110142887A1 (en) 2009-12-15 2010-12-14 Methods and compositions for liquidation of tumors
CN2010800575066A CN102740874A (zh) 2009-12-15 2010-12-15 肿瘤液化的方法和组合物

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US (4) US20110142887A1 (pt)
EP (1) EP2512502B1 (pt)
JP (3) JP6278597B2 (pt)
KR (1) KR101837561B1 (pt)
CN (2) CN102740874A (pt)
BR (1) BR112012014569A8 (pt)
CA (1) CA2786585C (pt)
DK (1) DK2512502T3 (pt)
ES (1) ES2667295T3 (pt)
HK (1) HK1222804A1 (pt)
HU (1) HUE037105T2 (pt)
IL (1) IL220386B (pt)
NO (1) NO2512502T3 (pt)
PL (1) PL2512502T3 (pt)
PT (1) PT2512502T (pt)
WO (1) WO2011084451A2 (pt)

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US20160206718A1 (en) 2016-07-21
JP2018090605A (ja) 2018-06-14
CN102740874A (zh) 2012-10-17
ES2667295T3 (es) 2018-05-10
JP6553219B2 (ja) 2019-07-31
PL2512502T3 (pl) 2018-08-31
EP2512502A2 (en) 2012-10-24
IL220386B (en) 2020-04-30
CA2786585C (en) 2019-11-26
NO2512502T3 (pt) 2018-08-18
PT2512502T (pt) 2018-05-02
EP2512502A4 (en) 2013-05-08
CA2786585A1 (en) 2011-07-14
HK1222804A1 (zh) 2017-07-14
JP2016121164A (ja) 2016-07-07
WO2011084451A3 (en) 2011-10-27
DK2512502T3 (en) 2018-05-07
US20220273784A1 (en) 2022-09-01
HUE037105T2 (hu) 2018-08-28
KR20120095418A (ko) 2012-08-28
JP6278597B2 (ja) 2018-02-14
US20110142887A1 (en) 2011-06-16
WO2011084451A2 (en) 2011-07-14
BR112012014569A2 (pt) 2016-08-16
EP2512502B1 (en) 2018-03-21
KR101837561B1 (ko) 2018-04-26
BR112012014569A8 (pt) 2017-12-26
US20140178334A1 (en) 2014-06-26

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