CN105457009A - Traditional Chinese medicine effective part combination for treating hypertension and hyperlipidemia and preparation method and application thereof - Google Patents

Traditional Chinese medicine effective part combination for treating hypertension and hyperlipidemia and preparation method and application thereof Download PDF

Info

Publication number
CN105457009A
CN105457009A CN201610012604.7A CN201610012604A CN105457009A CN 105457009 A CN105457009 A CN 105457009A CN 201610012604 A CN201610012604 A CN 201610012604A CN 105457009 A CN105457009 A CN 105457009A
Authority
CN
China
Prior art keywords
crude drug
hyperlipidemia
extracting solution
chinese medicine
traditional chinese
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610012604.7A
Other languages
Chinese (zh)
Inventor
康林芝
秦艳
云帆
王娜
唐惠奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GUANGZHOU AOJIAN FENGZE BIOLOGICAL TECHNOLOGY CO LTD
Original Assignee
GUANGZHOU AOJIAN FENGZE BIOLOGICAL TECHNOLOGY CO LTD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GUANGZHOU AOJIAN FENGZE BIOLOGICAL TECHNOLOGY CO LTD filed Critical GUANGZHOU AOJIAN FENGZE BIOLOGICAL TECHNOLOGY CO LTD
Priority to CN201610012604.7A priority Critical patent/CN105457009A/en
Publication of CN105457009A publication Critical patent/CN105457009A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738—Rosa (rose)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a traditional Chinese medicine effective part combination for treating hypertension and hyperlipidemia and a preparation method and application thereof. The traditional Chinese medicine effective part combination is prepared from ampelopsis grossedentata leaves, single roxburgh rose fruits, liquorice, rhizoma zingiberis, roots of kudzu vines, mulberries, chrysanthemum, fruits of Chinese wolfberries and hovenia dulcis thunb. The traditional Chinese medicine effective part combination has the effects of lowering blood fat, lowering blood sugar, balancing blood pressure, improving sleep, eliminating chest distress, calming and the like, has the advantages of being high in effective pressure lowering component content, pure natural, free of toxic or side effect, free of dependence and the like and is suitable for application and popularization.

Description

A kind ofly be used for the treatment of Chinese medicinal effective-part composition of hypertension and hyperlipidemia and its preparation method and application
Technical field
The present invention relates to the application of Chinese medicine composition in treatment hypertension class disease, be specifically related to a kind ofly be used for the treatment of Chinese medicinal effective-part composition of hypertension and hyperlipidemia and its preparation method and application.
Background technology
Hypertension refers to that systolic arterial pressure and/or diastolic pressure increase under quiescent condition, often with organ functional or organic changes such as fat and sugar metabolism disorder and the heart, brain, kidney and retinas.Hypertension and hyperglycemia, hyperlipidemia are together called " three-hypers ", are called as " the invisible killer " of human health, are one of main diseases kinds of chronic disease.Along with the quickening of people's rhythm of life, Prevalence of Hypertension increases and generally day by day.Once suffer from hypertension, the state of an illness can only be suppressed by long-term taking antihypertensive drugs, usually based on Western medicine.Though Western medicine can reduce blood pressure rapidly, also there is certain side effect in long-term taking, brings injury to patient body.Also there are some Chinese herbal medicine blood-pressure decreasing teas etc. in existing market, but uses blood-pressure decreasing tea blood pressure lowering to there is the shortcomings such as not convenient and effective ingredient amount of precipitation is few, and therapeutic effect is also barely satisfactory.
Summary of the invention
The object of the invention is to the medicine above shortcomings part according to diseases such as existing treatment hypertension, hyperlipemias, a kind of Chinese medicinal effective-part composition being used for the treatment of hypertension and hyperlipidemia newly is now provided, both there is the effects such as blood fat reducing, blood sugar lowering, balancing blood pressure, improving water flood, elimination be uncomfortable in chest, calm, also there is the advantages such as effective antihypertensive compositions content is high, Pure natural nontoxic side effect, no dependence.
Another object of the present invention is to provide the above-mentioned preparation method being used for the treatment of the Chinese medicinal effective-part composition of hypertension and hyperlipidemia.
A further object of the invention is the application providing above-mentioned Chinese medicinal effective-part composition.
Above-mentioned purpose of the present invention is achieved by the following technical programs:
Be used for the treatment of a Chinese medicinal effective-part composition for hypertension and hyperlipidemia, be made up of the following crude drug according to mass percentage: Ampelopsis grossedentata leaf 20 ~ 30%, Single Roxburgh Rose Fruit 6 ~ 10%, Radix Glycyrrhizae 3 ~ 8%, Rhizoma Zingiberis 6 ~ 10%, Radix Puerariae 10 ~ 15%, Fructus Mori 6 ~ 10%, Flos Chrysanthemi 6 ~ 10%, Fructus Lycii 5 ~ 10% and Semen Hoveniae (Fructus Hoveniae) 5 ~ 10%.
In order to make Chinese medicinal effective-part composition of the present invention play optimal efficacy, be prepared into effective antihypertensive compositions content high and facilitate portative oral liquid, preparation method is as follows:
(1) after each crude drug being pulverized and sieved, be placed in extracting cylinder, add 50 ~ 70 volume % ethanol of the plant composite hydrolytic enzyme (buying in Novozymes Company) of 5 ~ 10 ‰, 3 ~ 5 times of solid-liquid ratios, be warming up to 40 ~ 50 DEG C, constant temperature soaks enzymolysis 30 ~ 40min;
(2) add the ethanol of 50 ~ 70% to 10 ~ 20 times of crude drug, under ultrasonic power is 250 ~ 350W, extracts 40 ~ 60min, crosses leaching filtrate, obtain extracting solution, staticly settle 8 ~ 12h, cross leaching filtrate;
(3) add equal-volume water by concentrated for last for step (3) gained filtrate except alcohol, filter after disengaging precipitation, filtrate is concentrated into 2 ~ 4 times of crude drug gross mass, obtains final extracting solution;
(4) final extracting solution is added syrup and carry out dosing, make in the every 10ml extracting solution prepared containing crude drug amount 5 ~ 10g.
More than making oral liquid is only that Chinese medicinal effective-part composition of the present invention is made more preferably dosage form, all the other common dosage forms also can be selected, its preparation process can slightly be distinguished according to different dosage form, but all belongs to the common production process in this area, repeats no more herein.
Compared with prior art, the present invention has following beneficial effect:
(1) Chinese medicinal effective-part composition of the present invention is pure natural raw material, and belong to integration of edible and medicinal herbs and foodstuff, not only have the effects such as blood pressure lowering, long-term drink has opsonic action to human body, does not have any toxic and side effects and dependency;
(2) described Chinese medicinal effective-part composition is made oral liquid by the present invention, is convenient for carrying, and can drink at any time, mouthfeel is better.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but embodiment does not limit in any form the present invention.
Embodiment 1
Crude drug: Ampelopsis grossedentata leaf 29g, Single Roxburgh Rose Fruit 8g, Radix Glycyrrhizae 8g, Rhizoma Zingiberis 7.5g, Radix Puerariae 13.6g, Fructus Mori 8.4g, Flos Chrysanthemi 9.2g, Fructus Lycii 8g, Semen Hoveniae (Fructus Hoveniae) 8.3g.
Prepare oral liquid, comprise the steps:
(1) pulverize and sieve: above-mentioned raw materials was pulverized 80 mesh sieves, for subsequent use;
(2) get (1) gained raw material and be placed in extracting cylinder, add 7 ‰ plant composite hydrolytic enzymes, the ethanol of 5 times of (solid-liquid ratios) 60% is warming up to 45 DEG C of constant temperature and soaks enzymolysis 30min;
(3) add the ethanol of 60% to 20 times (whole solid-liquid ratios) of raw material, when ultrasonic power 300W, extract 60min.Cross leaching filtrate, obtain extracting solution, staticly settle 12h, cross leaching filtrate;
(4) get step 3 filtrate to concentrate except alcohol, add equal-volume water, filter after disengaging precipitation, filtrate is concentrated into 2 times of raw material gross mass.Obtain final extracting solution for subsequent use;
(5) add syrup with extracting solution and carry out dosing, make the every 10ml extracting solution prepared containing the suitable 6g of crude drug amount.
Embodiment 2
Raw material: Ampelopsis grossedentata leaf 25.2g, Single Roxburgh Rose Fruit 9g, Radix Glycyrrhizae 8g, Rhizoma Zingiberis 6.5g, Radix Puerariae 15g, Fructus Mori 10g, Flos Chrysanthemi 10g, Fructus Lycii 8g, Semen Hoveniae (Fructus Hoveniae) 8.3g.
Prepare oral liquid, comprise the steps:
(1) pulverize and sieve: above-mentioned raw materials was pulverized 80 mesh sieves, for subsequent use;
(2) get (1) gained raw material and be placed in extracting cylinder, add 5 ‰ plant composite hydrolytic enzymes, the ethanol of 3 times of (solid-liquid ratios) 70% is warming up to 45 DEG C of constant temperature and soaks enzymolysis 30min;
(3) add the ethanol of 70% to 15 times (whole solid-liquid ratios) of raw material, when ultrasonic power 350W, extract 50min.Cross leaching filtrate, obtain extracting solution, staticly settle 8h, cross leaching filtrate.
(4) get step 3 filtrate to concentrate except alcohol, add equal-volume water, filter after disengaging precipitation, filtrate is concentrated into 3 times of raw material gross mass.Obtain final extracting solution for subsequent use;
(5) add syrup with extracting solution and carry out dosing, make the every 10ml extracting solution prepared containing the suitable 5g of crude drug amount.
Experimental example 1
Choose patient 400 people, all through clinical diagnosis be hypertension.Patient is divided into four groups, A group is blank group, and B group is the request for utilization number medicine that is the optimum proportioning of the blood-pressure decreasing tea drink formula disclosed in the application for a patent for invention of 200910306676.2 as a control group 1; C group is the request for utilization number medicine that is the optimum proportioning in the health-care tea disclosed in the application for a patent for invention of 201210002970.6 as a control group 2; D group is the oral liquid that the embodiment of the present application 1 obtains, using method: every day twice, each 5ml.
Therapeutic effect is divided into effective, effective and invalid, is specially effective: diastolic pressure more than decline 1.3KPa, and reaches normal range; Though or diastolic pressure is not down to normally, more than decline 2.6KPa; Effective: diastolic pressure declines not as good as 1.3KPa, but reaches normal range; Or diastolic pressure comparatively treats the front 1.3 ~ 2.34KPa that declines, but do not reach normal range; Or systolic pressure comparatively treats front more than decline 4.0KPa; Invalid: not reach effective standard.
Medication is after 90 days, and result is as shown in table 1.
Table 1
Group A B C D
Effective 0 22 27 89
Effectively 0 35 49 10
Invalid 100 43 24 1
As shown in Table 1, gained oral liquid of the present invention is used for the treatment of hypertension, evident in efficacy, is much better than B group and C group.
Experimental example 2
Choose patient 400 people, all through clinical diagnosis be hyperlipidemia.Patient is divided into four groups, A group is blank group, and B group is the request for utilization number medicine that is the optimum proportioning of the blood-pressure decreasing tea drink formula disclosed in the application for a patent for invention of 200910306676.2 as a control group 1; C group is the request for utilization number medicine that is the optimum proportioning in the health-care tea disclosed in the application for a patent for invention of 201210002970.6 as a control group 2; D group is the oral liquid that the embodiment of the present application 2 obtains.
Therapeutic effect is divided into effective, effective and invalid, is specially effective: after treatment, clinical symptoms disappears substantially, and serum cholesterol and triglyceride are replied normally or its drop-out value is greater than 40mg%; Effective: thick through treating, clinical symptoms makes moderate progress, serum cholesterol, triglyceride drop-out value are more than or equal to 20mg%; Invalid: after treatment, clinical symptoms is slightly improved or without improvement, serum cholesterol, triglyceride drop-out value are at below 20mg%.
Result is as shown in table 2.
Table 2
Group A B C D
Effective 0 31 42 90
Effectively 0 33 31 10
Invalid 100 36 27 0
As shown in Table 2, gained oral liquid of the present invention is used for the treatment of high fat of blood, evident in efficacy, is much better than B group and C group.
Experimental example 3
The liver function of the D group experimental subject of checking experiment example 1 and 2, routine blood test, routine urinalysis and stool.Result shows, and the indices of experimental subject is and notes abnormalities, and therefore the safety of known Chinese medicinal effective-part composition of the present invention is good.

Claims (3)

1. be used for the treatment of a Chinese medicinal effective-part composition for hypertension and hyperlipidemia, it is characterized in that being made up of the following crude drug according to mass percentage: Ampelopsis grossedentata leaf 20 ~ 30%, Single Roxburgh Rose Fruit 6 ~ 10%, Radix Glycyrrhizae 3 ~ 8%, Rhizoma Zingiberis 6 ~ 10%, Radix Puerariae 10 ~ 15%, Fructus Mori 6 ~ 10%, Flos Chrysanthemi 6 ~ 10%, Fructus Lycii 5 ~ 10% and Semen Hoveniae (Fructus Hoveniae) 5 ~ 10%.
2. be used for the treatment of the Chinese medicinal effective-part composition of hypertension and hyperlipidemia described in claim 1, it is characterized in that being prepared into oral liquid, preparation method is as follows:
(1) after being pulverized and sieved by each crude drug, be placed in extracting cylinder, add 50 ~ 70 volume % ethanol of the plant composite hydrolytic enzyme of 5 ~ 10 ‰, 3 ~ 5 times of solid-liquid ratios, be warming up to 40 ~ 50 DEG C, constant temperature soaks enzymolysis 30 ~ 40min;
(2) add the ethanol of 50 ~ 70% to 10 ~ 20 times of crude drug, under ultrasonic power is 250 ~ 350W, extracts 40 ~ 60min, crosses leaching filtrate, obtain extracting solution, staticly settle 8 ~ 12h, cross leaching filtrate;
(3) add equal-volume water by concentrated for last for step (3) gained filtrate except alcohol, filter after disengaging precipitation, filtrate is concentrated into 2 ~ 4 times of crude drug gross mass, obtains final extracting solution;
(4) final extracting solution is added syrup and carry out dosing, make in the every 10ml extracting solution prepared containing crude drug amount 5 ~ 10g.
3. Chinese medicinal effective-part composition described in claim 1 or 2 is preventing or is treating the application in blood fat reducing, blood sugar lowering, balancing blood pressure disease.
CN201610012604.7A 2016-01-05 2016-01-05 Traditional Chinese medicine effective part combination for treating hypertension and hyperlipidemia and preparation method and application thereof Pending CN105457009A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610012604.7A CN105457009A (en) 2016-01-05 2016-01-05 Traditional Chinese medicine effective part combination for treating hypertension and hyperlipidemia and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610012604.7A CN105457009A (en) 2016-01-05 2016-01-05 Traditional Chinese medicine effective part combination for treating hypertension and hyperlipidemia and preparation method and application thereof

Publications (1)

Publication Number Publication Date
CN105457009A true CN105457009A (en) 2016-04-06

Family

ID=55595456

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610012604.7A Pending CN105457009A (en) 2016-01-05 2016-01-05 Traditional Chinese medicine effective part combination for treating hypertension and hyperlipidemia and preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN105457009A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1120454A (en) * 1995-09-06 1996-04-17 杭州娃哈哈集团公司 Beverage for sobering up and removing nicotine
CN102499298A (en) * 2012-01-06 2012-06-20 雷雨田 Health care tea and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1120454A (en) * 1995-09-06 1996-04-17 杭州娃哈哈集团公司 Beverage for sobering up and removing nicotine
CN102499298A (en) * 2012-01-06 2012-06-20 雷雨田 Health care tea and preparation method thereof

Similar Documents

Publication Publication Date Title
CN102988638B (en) Cyclocarya paliurus blood-lipid and blood-sugar reducing health-care tea and preparation method thereof
CN103168883A (en) Pathogenic microorganism preventing antiviral tea beverage granules capable of boosting immunity and preparation method thereof
CN104147385B (en) A kind of formula of Chinese medicine for lowering blood pressure preparation and preparation method
CN104082672B (en) A kind of health-preserving porridge with effect of lowering blood sugar and preparation method thereof
CN106038670A (en) Preparation method of Vaccinium dunalianum Wight extract
CN103689152A (en) Herbal tea for tonifying kidney and removing heat from liver and preparation method thereof
CN106176953A (en) A kind of Hyperglycemic health care compositions comprising leaf of Cyclocarya paliurus Iljinskaja, Fructus Momordicae and Folium Mori
CN104474472B (en) Buccal lozenge of lectuce tea and its production method with three high drop effect
CN107412665B (en) It is a kind of that there is Chinese medicine composition for relieving the effect of alcohol, preventing alcoholic liver injury and its preparation method and application
CN108813501A (en) With the relieving cough and reducing sputum health honey paste relievingd asthma and adjust function of human body of clearing heat and moistening lung
CN102604802B (en) Preparation method of originally ecological bamboo-germanium nutritional wine
CN103977390B (en) A kind of preparation method and its usage of ginger onion medicated wine composition
CN104225295B (en) Composition for improving sleep, and preparation method and application thereof
CN103202956A (en) Antihypertensive life-preserving health-care medicinal liquor
CN104906190A (en) Antler powder wine and preparation method thereof
CN102613648B (en) Preparation method of original ecological bamboo germanium nutrient solution
CN104450470A (en) Cudrania tricuspidata fruit health care wine and preparation method thereof
CN103798472B (en) A kind of health protection tea and health care's preparation
CN106729518A (en) A kind of tea beverage of hypotensive and preparation method and application
CN102846720B (en) Composite for lowering blood fat and improving anoxia endurance
CN104606571A (en) Fresh spinach root tea substituted drink with effects of helping produce saliva and slaking thirst and preparation method thereof
CN105457009A (en) Traditional Chinese medicine effective part combination for treating hypertension and hyperlipidemia and preparation method and application thereof
CN105012743A (en) Health maintaining congee with antihypertensive effect
CN104223062B (en) Root bark of Chinese wolf-berry health care oral liquid of a kind of reducing pressure and sugar and preparation method thereof
CN106728828A (en) A kind of Chinese medicine preparation and its preparation technology for treating coronary heart disease

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20160406

RJ01 Rejection of invention patent application after publication