CN105456618A - Granule for treating mesenteric lymphadenitis in children and application thereof - Google Patents

Granule for treating mesenteric lymphadenitis in children and application thereof Download PDF

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CN105456618A
CN105456618A CN201610014893.4A CN201610014893A CN105456618A CN 105456618 A CN105456618 A CN 105456618A CN 201610014893 A CN201610014893 A CN 201610014893A CN 105456618 A CN105456618 A CN 105456618A
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parts
radix
granule
herba
grams
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陈令浩
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Qingdao Chenda Biotechnology Co Ltd
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Qingdao Chenda Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/11—Pteridophyta or Filicophyta (ferns)
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Abstract

The invention relates to a granule for treating the mesenteric lymphadenitis in children and application thereof. The granule is prepared from, by weight, 10-15 parts of herba houttuyniae, 10-20 parts of pine pollen, 8-12 parts of common scouring rush herb, 8-15 parts of herba fibraureae recisae, 10-15 parts of cortex lycii radicis, 10-15 parts of puerarin, 10-30 parts of scorched hawthorn fruit, 10-20 parts of radix isatidis, 2-15 parts of caesalpinia sappan L., 9-18 parts of astragalus complanatus, 3-10 parts of picria fel-terrae, 8-15 parts of sichuan lovage rhizomes, 7-14 parts of radix paeoniae alba, 2-10 parts of melia toosendan, 3-8 parts of agastache rugosa, 10-15 parts of poria cocos, 2-8 parts of liquorice roots, 10-15 parts of dried citrus peel, 8-12 parts of folium ginkgo, 5-10 parts of rhizoma cyperi and 10-20 parts of bupleurum. The adopted pure traditional Chinese medicines are reasonable in formula and have functions of stopping pain and clearing away heat, and adjusting spleen and stomach; it is proved through pharmacology experiments and clinical experiments that the total efficiency of the medicine preparation reaches 100% and no adverse reaction happens in the clinical medicine use process; the granule has good economic and social value; the granule is simple in preparation process and low in cost, auxiliary materials added to the granule are good in taste, and the compliance of patients is improved.

Description

A kind of granule being used for the treatment of infantile adenomesenteritis and uses thereof
Technical field
The present invention relates to treatment by Chinese herbs field, be specifically related to a kind of granule being used for the treatment of infantile adenomesenteritis and uses thereof.
Background technology
Along with the change of diet structure, the changes in diet multiterminal of children's, various Pediatric Gastrointestinal advancing of disease is also very rapid, wherein, infantile adenomesenteritis is the disease that sickness rate is higher in recent years, it is generally acknowledged that the generation of this disease and upper respiratory tract infection are related.Clinical manifestation is heating, suffers from abdominal pain, vomits, or diarrhoea or constipation occur.This disease is more common in the child of less than 7 years old, and pain is many in paroxysmal, recurrent exerbation.Stomachache resembles angor sometimes at right lower abdomen, also can at other positions, therefore easily mistaken diagnosis is acute appendicitis.
Infantile adenomesenteritis is the commonly encountered diseases and the frequently-occurring disease that cause abdominal pain in children, common with 5-8 year, the a little higher than girl of research in recent years display boy's prevalence, this disease is many because of caused by virus, bacteriological infection, along with the raising of the universal of abdominal part color Doppler ultrasonography and technology, infantile adenomesenteritis diagnosis obviously rises, and is cardinal symptom clinically, often with heating, pharyngalgia, cough, vomiting, poor appetite, constipation etc. with stomachache.Because the feature of primary disease stomachache is paroxysmal abdominal pain, with Right Lower Abdomen and umbilicus Zhou Duojian, pain gap is without significant discomfort, therefore the part head of a family does not draw attention, do not give diagnosis and treatment of seeking medical advice, also there is part doctor to be only thought of as cramps of gastrointestinal tract in the past, or think helminth disease, give oral intestinal canal probiotic bacteria or anthelmintic, therapeutic effect is undesirable, but does yet to check further and treat and cause failing to pinpoint a disease in diagnosis, and the state of an illness is easily delayed, cause recurrent exerbation of suffering from abdominal pain, the work and rest even affecting children's, with movable, all causes certain psychological burden to infant and family members.And prolonged and repeated outbreak of suffering from abdominal pain, gastrointestinal function is influenced, and cause infant inappetence, digestive function is impaired, causes alimentation bad, causes infantile malnutrition for a long time in the past, and the normal growth affecting child is grown.
Adenomesenteritis is attributed to by motherland's Chinese medicine " stomachache, scrofula " category.Be easy to feel exopathogen, feel exopathogen again, the evil heap soil or fertilizer over and around the roots stagnation of QI, the spleen tending to insufficiency usually, easy accumulatively wet raise phlegm, mental disorder hands over resistance, ties in abdominal part, stagnation of QI and blood may bring about pain.Primary disease is belonged to stomachache card category according to clinical manifestation by Chinese medicine, thinks that its cause of disease has endogenous cause of ill therefore to divide outward.After endogenous cause of ill is mainly children's's birth, all more tender and lovely fragility of the vital organs of the human body, its physique structure, essence and blood body fluid and gasification function are all not mature enough and relative deficiency.The morphological development of each organs and systems of body and physiological function are all immature and incomplete.Outer because pediatric diet can not from joint, hungry full can not self-regulated, or eating and drinking too much at one meal, or addiction to uncooked and cold food, delicious food, fish raw meat, greasy product, eat vegetable less, and drinking-water is less or face sleeping polyphagia etc. and make taste impaired.
At present, drop, except extra-nutrition moisture electrolyte water, still has anti-diarrhea effect.When all antidiarrheals are invalid, the antidiarrheal therapy that drop is best especially.But sick child's physical weakness, comparatively large to nutritional need, drop can't resolve.When there is intussusception, child is necessarily with obvious stomachache, cry and scream more than, when there is polyp, there will be continue hemorrhage on a small quantity, only have special bowel radiography just can make a definite diagnosis, and normal colonic mucosa metabolic comes off, child shows without any difference, and growth promoter is normal.Mostly be anti-inflammation, anti symptom treatment to the medical treatment of infantile lymphonodi mesenterici inflammation clinically, there is no good plan, allow numerous children's's sup sorrow, the good medicine effected a permanent cure that do not take stopgap measures settles the matter once and for all.
Summary of the invention
In view of prior art defect, the present invention in depth studies through inventor, obtains a kind of prescriptions of Chinese medicine for the treatment of lymphadenitis, especially infantile adenomesenteritis is applicable to, for the discovery that prescription the present inventor is pleasantly surprised, the effect of the medicament of this prescription is good, has no side effect.
First object of the present invention is, inventor carries out a large amount of investigative test to the consumption of drug component, provide a kind of prescriptions of Chinese medicine for the treatment of infantile adenomesenteritis, the raw material that prescription comprises comprises: Herba Houttuyniae, Pollen Pini, Herba Equiseti Hiemalis, Caulis Fibraureae, Cortex Lycii, Radix Puerariae, Fructus Crataegi (parched to brown), Radix Isatidis, Lignum Sappan, Semen Astragali Complanati, Radix Picriae felterrae, Rhizoma Chuanxiong, Radix Paeoniae Alba, Fructus Toosendan, Herba Pogostemonis, Poria, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Folium Ginkgo, Rhizoma Cyperi, Radix Bupleuri.
Each raw material dosage of prescription all has good curative effect in weight portion scope of the present invention, described formula and component are Herba Houttuyniae 10-15 part, Pollen Pini 10-20 part, Herba Equiseti Hiemalis 8-12 part, Caulis Fibraureae 8-15 part, Cortex Lycii 10-15 part, Radix Puerariae 10-15 part, Fructus Crataegi (parched to brown) 10-30 part, Radix Isatidis 10-20 part, Lignum Sappan 2-15 part, Semen Astragali Complanati 9-18 part, Radix Picriae felterrae 3-10 part, Rhizoma Chuanxiong 8-15 part, Radix Paeoniae Alba 7-14 part, Fructus Toosendan 2-10 part, Herba Pogostemonis 3-8 part, Poria 10-15 part, Radix Glycyrrhizae 2-8 part, Pericarpium Citri Reticulatae 10-15 part, Folium Ginkgo 8-12 part, Rhizoma Cyperi 5-10 part, Radix Bupleuri 10-20 part.
Carry out preferably to the formula of above-mentioned weight portion, reach better technique effect, preferred formula is: Herba Houttuyniae 12 parts, Pollen Pini 15 parts, Herba Equiseti Hiemalis 10 parts, Caulis Fibraureae 11.5 parts, Cortex Lycii 12 parts, Radix Puerariae 12 parts, Fructus Crataegi (parched to brown) 15 parts, Radix Isatidis 15 parts, Lignum Sappan 8 parts, Semen Astragali Complanati 13 parts, Radix Picriae felterrae 6.5 parts, Rhizoma Chuanxiong 11 parts, Radix Paeoniae Alba 10 parts, Fructus Toosendan 6 parts, Herba Pogostemonis 5 parts, 12 parts, Poria, 5 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 12 parts, Folium Ginkgo 10 parts, Rhizoma Cyperi 7 parts, Radix Bupleuri 15 parts.Or:
Herba Houttuyniae 11 parts, Pollen Pini 14 parts, Herba Equiseti Hiemalis 9 parts, Caulis Fibraureae 10.5 parts, Cortex Lycii 10 parts, Radix Puerariae 11 parts, Fructus Crataegi (parched to brown) 17 parts, Radix Isatidis 14 parts, Lignum Sappan 7 parts, Semen Astragali Complanati 12 parts, Radix Picriae felterrae 5.5 parts, Rhizoma Chuanxiong 10 parts, Radix Paeoniae Alba 9 parts, Fructus Toosendan 5.5 parts, Herba Pogostemonis 4 parts, 11 parts, Poria, 4 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 10 parts, Folium Ginkgo 11 parts, Rhizoma Cyperi 7 parts, Radix Bupleuri 14 parts.
A kind of granule being used for the treatment of infantile adenomesenteritis of the present invention, utilizes above-mentioned raw material to be prepared into oral formulations, in order to the consideration more adapted on children's and pharmacodynamics is preferably granule.
A kind of granule being used for the treatment of infantile adenomesenteritis of the present invention, preparation method is specially:
(1) Herba Houttuyniae, Pericarpium Citri Reticulatae, Folium Ginkgo, Rhizoma Cyperi, Radix Bupleuri, Cortex Lycii, Herba Equiseti Hiemalis, Radix Isatidis, Rhizoma Chuanxiong and Radix Paeoniae Alba mixing is taken, add 8-10 times of water soaking, then decoct 2 times, 1.5 hours first times, second time 1 hour, merges decoction liquor, filters, being evaporated to relative density is 1.18, for subsequent use;
(2) Pollen Pini, Caulis Fibraureae is taken, Radix Puerariae, Fructus Crataegi (parched to brown), Lignum Sappan, Semen Astragali Complanati, Radix Picriae felterrae, Fructus Toosendan, Herba Pogostemonis, Poria, and Radix Glycyrrhizae mixing, be ground into coarse powder, 13 times of volumetric concentrations are the alcoholic solution reflux, extract, 3 times of 85%, each 2 hours, merge ethanol extract, for subsequent use;
(3) add in the ethanol extract of step (2) by the concentrated solution of step (1), stir, hold over night, centrifugal, supernatant is condensed into extractum, lyophilization after reclaiming ethanol, pulverizes, obtains clear paste powder;
(4) mixed homogeneously with pharmaceutically acceptable adjuvant by step (3) gained clear paste powder, then wet granulation, obtains granule.
In above-mentioned preparation method, described pharmaceutically acceptable adjuvant and the weight part ratio of clear paste powder are 0.1-0.21.Be preferably 0.15:1.
In above-mentioned preparation method, described pharmaceutically acceptable adjuvant comprises filler, binding agent, described filler be sucrose, lactose, mannitol, dextrin one or both, be preferably lactose, described binding agent is the one of the aqueous solution of 50% alcoholic solution of 3% hypromellose, the aqueous solution of 10% PVP K30,30% starch slurry and 10% carboxymethyl cellulose.Be preferably 50% alcoholic solution of 3% hypromellose.
A kind of granule being used for the treatment of infantile adenomesenteritis of the present invention, advantage is compared with prior art:
The present invention use pure Chinese prescription rationally, there is pain relieving to reduce phlegm and internal heat, regulate the merit of taste, confirming through pharmacological evaluation and clinical trial of pharmaceutical preparation of the present invention, total effective rate reaches 100%, untoward reaction is not there is in clinical application process, there is good economy and social value, preparation technology of the present invention is simple, cost is lower, and the adjuvant mouthfeel of adding in granule is better, improves the compliance of patient.
Specific embodiment
Although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Embodiment 1: a kind of granule for the treatment of adenomesenteritis, the composition containing following weight in grams:
Herba Houttuyniae 10 grams, Pollen Pini 10 grams, Herba Equiseti Hiemalis 8 grams, Caulis Fibraureae 8 grams, Cortex Lycii 10 grams, Radix Puerariae 10 grams, Fructus Crataegi (parched to brown) 10 grams, Radix Isatidis 10 grams, Lignum Sappan 2 grams, Semen Astragali Complanati 9 grams, Radix Picriae felterrae 3 grams, Rhizoma Chuanxiong 8 grams, Radix Paeoniae Alba 7 grams, Fructus Toosendan 2 grams, Herba Pogostemonis 3 grams, 10 grams, Poria, 2 grams, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 10 grams, Folium Ginkgo 8 grams, Rhizoma Cyperi 5-10 gram, Radix Bupleuri 10 grams.Concrete preparation method is:
(1) Herba Houttuyniae, Pericarpium Citri Reticulatae, Folium Ginkgo, Rhizoma Cyperi, Radix Bupleuri, Cortex Lycii, Herba Equiseti Hiemalis, Radix Isatidis, Rhizoma Chuanxiong and Radix Paeoniae Alba mixing is taken, add 8-10 times of water soaking, then decoct 2 times, 1.5 hours first times, second time 1 hour, merges decoction liquor, filters, being evaporated to relative density is 1.18, for subsequent use;
(2) Pollen Pini, Caulis Fibraureae is taken, Radix Puerariae, Fructus Crataegi (parched to brown), Lignum Sappan, Semen Astragali Complanati, Radix Picriae felterrae, Fructus Toosendan, Herba Pogostemonis, Poria, and Radix Glycyrrhizae mixing, be ground into coarse powder, 13 times of volumetric concentrations are the alcoholic solution reflux, extract, 3 times of 85%, each 2 hours, merge ethanol extract, for subsequent use;
(3) add in the ethanol extract of step (2) by the concentrated solution of step (1), stir, hold over night, centrifugal, supernatant is condensed into extractum, lyophilization after reclaiming ethanol, pulverizes, obtains clear paste powder;
(4) lactose of step (3) gained clear paste powder and its weight 10% and dextrin (weight consumption is than being 1:1) mixs, 50% alcoholic solution then adding 3% hypromellose is granulated, and crosses 16 mesh sieves, dryly obtains granule.
Embodiment 2: a kind of granule for the treatment of adenomesenteritis, the composition containing following weight in grams:
Herba Houttuyniae 15 grams, Pollen Pini 20 grams, Herba Equiseti Hiemalis 12 grams, Caulis Fibraureae 15 grams, Cortex Lycii 15 grams, Radix Puerariae 15 grams, Fructus Crataegi (parched to brown) 30 grams, Radix Isatidis 20 grams, Lignum Sappan 15 grams, Semen Astragali Complanati 18 grams, Radix Picriae felterrae 10 grams, Rhizoma Chuanxiong 15 grams, Radix Paeoniae Alba 14 grams, Fructus Toosendan 10 grams, Herba Pogostemonis 8 grams, 15 grams, Poria, 8 grams, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 15 grams, Folium Ginkgo 12 grams, Rhizoma Cyperi 10 grams, Radix Bupleuri 20 grams.Concrete preparation method is:
(1) Herba Houttuyniae, Pericarpium Citri Reticulatae, Folium Ginkgo, Rhizoma Cyperi, Radix Bupleuri, Cortex Lycii, Herba Equiseti Hiemalis, Radix Isatidis, Rhizoma Chuanxiong and Radix Paeoniae Alba mixing is taken, add 8-10 times of water soaking, then decoct 2 times, 1.5 hours first times, second time 1 hour, merges decoction liquor, filters, being evaporated to relative density is 1.18, for subsequent use;
(2) Pollen Pini, Caulis Fibraureae is taken, Radix Puerariae, Fructus Crataegi (parched to brown), Lignum Sappan, Semen Astragali Complanati, Radix Picriae felterrae, Fructus Toosendan, Herba Pogostemonis, Poria, and Radix Glycyrrhizae mixing, be ground into coarse powder, 13 times of volumetric concentrations are the alcoholic solution reflux, extract, 3 times of 85%, each 2 hours, merge ethanol extract, for subsequent use;
(3) add in the ethanol extract of step (2) by the concentrated solution of step (1), stir, hold over night, centrifugal, supernatant is condensed into extractum, lyophilization after reclaiming ethanol, pulverizes, obtains clear paste powder;
(4) lactose of step (3) gained clear paste powder and its weight 20% and dextrin (weight consumption is than being 1:1) mixs, then adding 15% starch slurry and granulating, crossing 16 mesh sieves, dryly obtain granule.
Embodiment 3: a kind of granule for the treatment of adenomesenteritis, the composition containing following weight in grams:
Herba Houttuyniae 12 grams, Pollen Pini 15 grams, Herba Equiseti Hiemalis 10 grams, Caulis Fibraureae 11.5 grams, Cortex Lycii 12 grams, Radix Puerariae 12 grams, Fructus Crataegi (parched to brown) 15 grams, Radix Isatidis 15 grams, Lignum Sappan 8 grams, Semen Astragali Complanati 13 grams, Radix Picriae felterrae 6.5 grams, Rhizoma Chuanxiong 11 grams, Radix Paeoniae Alba 10 grams, Fructus Toosendan 6 grams, Herba Pogostemonis 5 grams, 12 grams, Poria, 5 grams, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 12 grams, Folium Ginkgo 10 grams, Rhizoma Cyperi 7 grams, Radix Bupleuri 15 grams.Concrete preparation method is:
(1) Herba Houttuyniae, Pericarpium Citri Reticulatae, Folium Ginkgo, Rhizoma Cyperi, Radix Bupleuri, Cortex Lycii, Herba Equiseti Hiemalis, Radix Isatidis, Rhizoma Chuanxiong and Radix Paeoniae Alba mixing is taken, add 8-10 times of water soaking, then decoct 2 times, 1.5 hours first times, second time 1 hour, merges decoction liquor, filters, being evaporated to relative density is 1.18, for subsequent use;
(2) Pollen Pini, Caulis Fibraureae is taken, Radix Puerariae, Fructus Crataegi (parched to brown), Lignum Sappan, Semen Astragali Complanati, Radix Picriae felterrae, Fructus Toosendan, Herba Pogostemonis, Poria, and Radix Glycyrrhizae mixing, be ground into coarse powder, 13 times of volumetric concentrations are the alcoholic solution reflux, extract, 3 times of 85%, each 2 hours, merge ethanol extract, for subsequent use;
(3) add in the ethanol extract of step (2) by the concentrated solution of step (1), stir, hold over night, centrifugal, supernatant is condensed into extractum, lyophilization after reclaiming ethanol, pulverizes, obtains clear paste powder;
(4) mannitol of step (3) gained clear paste powder and its weight 15% and dextrin (weight consumption is than being 1:1) mixs, then adding 15% starch slurry and granulating, crossing 16 mesh sieves, dryly obtain granule.
Embodiment 4: a kind of granule for the treatment of adenomesenteritis, the composition containing following weight in grams:
Herba Houttuyniae 11 grams, Pollen Pini 14 grams, Herba Equiseti Hiemalis 9 grams, Caulis Fibraureae 10.5 grams, Cortex Lycii 10 grams, Radix Puerariae 11 grams, Fructus Crataegi (parched to brown) 17 grams, Radix Isatidis 14 grams, Lignum Sappan 7 grams, Semen Astragali Complanati 12 grams, Radix Picriae felterrae 5.5 grams, Rhizoma Chuanxiong 10 grams, Radix Paeoniae Alba 9 grams, Fructus Toosendan 5.5 grams, Herba Pogostemonis 4 grams, 11 grams, Poria, 4 grams, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 10 grams, Folium Ginkgo 11 grams, Rhizoma Cyperi 7 grams, Radix Bupleuri 14 grams.Concrete preparation method is:
(1) Herba Houttuyniae, Pericarpium Citri Reticulatae, Folium Ginkgo, Rhizoma Cyperi, Radix Bupleuri, Cortex Lycii, Herba Equiseti Hiemalis, Radix Isatidis, Rhizoma Chuanxiong and Radix Paeoniae Alba mixing is taken, add 8-10 times of water soaking, then decoct 2 times, 1.5 hours first times, second time 1 hour, merges decoction liquor, filters, being evaporated to relative density is 1.18, for subsequent use;
(2) Pollen Pini, Caulis Fibraureae is taken, Radix Puerariae, Fructus Crataegi (parched to brown), Lignum Sappan, Semen Astragali Complanati, Radix Picriae felterrae, Fructus Toosendan, Herba Pogostemonis, Poria, and Radix Glycyrrhizae mixing, be ground into coarse powder, 13 times of volumetric concentrations are the alcoholic solution reflux, extract, 3 times of 85%, each 2 hours, merge ethanol extract, for subsequent use;
(3) add in the ethanol extract of step (2) by the concentrated solution of step (1), stir, hold over night, centrifugal, supernatant is condensed into extractum, lyophilization after reclaiming ethanol, pulverizes, obtains clear paste powder;
(4) mannitol of step (3) gained clear paste powder and its weight 15% and dextrin (weight consumption is than being 1:1) mixs, then adding 15% starch slurry and granulating, crossing 16 mesh sieves, dryly obtain granule.
Embodiment 5: the treatment of the rat mesenteric lymph node inflammation that salmonella copies
Salmonella is that the gram negative bacilli that in the large numbers of human and animal's of parasitizing intestinal, biochemical reaction is similar with antigen construct is referred to as Salmonella, causes heating, leukopenia.The endotoxin of its secretion activating complement system can discharge chemotactic factor, attracts granulocyte, causes intestinal local inflammation to react.After antibacterial arrives small intestinal, invade intestinal wall lymphoid tissue through intestinal epithelial cell, also breed wherein to mesenteric lymph node and other lymphoid tissues through lymphatic vessel, cause the phenomenon such as pain, lymphadenectasis.
5.1, model is set up and administration:
5 week age white mice 120, male and female half and half, random assortment becomes 5 groups, normal group (5ml normal saline), treatment by Chinese herbs I group (preparation of embodiment 3) (8g/kg), treatment by Chinese herbs II group (preparation of embodiment 4) (10g/kg) and the oral positive controls of SHUANGHUANLIAN (3ml/kg), matched group, the preparation of described treatment by Chinese herbs group prepares according to the embodiment of the present invention 5.Often organize every day respectively gastric infusion feed relative medicine solution 1 time, successive administration 7 days.Except normal group, other each treatment group animals are all in the 4th day subcutaneous injection salmonella (configuring before 1 week) 0.5ml, and within the 8th day after administration, medicine mouse body pain of breaking afterwards reverses situation (in 24 hours); A normal group otch is left intact.
Statistical method data represent with mean ± standard deviation (± s).T inspection between employing group is compared between group.Be that difference has significance with P<0.05, P<0.01 is that difference has very significant.
5.2, experimental result and analysis
Continuously recorded mouse body through 24 hours and reverse situation, concrete number of torsions is in table 1.
Table 1 treatment group and matched group health reverse observation situation
Group Health grapples number of times Times of defecation (secondary/24h)
Normal group 0.75±0.33 1.6±1.4##
Model group 17.69±3.98 6.6±3.5
Treatment by Chinese herbs I group 4.33±5.63## 1.5±3.0##
Treatment by Chinese herbs II group 4.41±4.32## 1.8±2.8##
The oral positive controls of SHUANGHUANLIAN 5.01±6.32## 2.2±4.2#
Compared with model group, ##P < 0.01.
As can be seen from Table 1,
5.3, MPO determination of activity
Mice modeling experiment is as 5.1, and 100 mices are divided into 5 groups, and the high, medium and low dosage group of model group, positive controls, granule often organizes 20, administering mode, kind and dose as table 1, Normal group 20.Successive administration 4 days.
Table 2 tests the administering mode of each group of mice, kind and dose situation
After test, experimental mice is put to death, Ge Zu small intestine is taken out and weighs, every 200mg adds 1ml0.2%HTAB, homogenate, freeze-thaw 3 times, 1000 leave heart 10min, get 0.1ml supernatant, take dianisidine as substrate, measure the average of 5min internal absorbance change in wavelength 655nm place with UV-200 type ultraviolet spectrophotometer, absorbance change 1.0 per minute is 1 unit of enzyme activity.Concrete data are in table 3.
Table 3MPO measurement result
MPO(U/g)
Normal group 1.01±0.33 ##
Model group 4.69±0.83
Granule high dose group 1.05±0.26 ##▲
Dosage group in granule 2.42±0.25 #
Granule low dose group 3.03±0.41 #
Positive controls 3.12±0.37 #
Compared with model group, #p < 0.05, ##p < 0.01;
Compared with positive controls, ▲p < 0.05.
MPO measurement result is shown by table 3 result, positive controls and each dosage group of granule all clearly can play the effect for the treatment of, but granule high dose group and positive controls have significant technique effect (P < 0.05), can apply in clinical further.
Embodiment 6: classical case
Case 1: the Qin, man, 2 years old 02 months, people from Linyi, Shandong, patient suffers from diarrhoea about 5 days, constantly keeps crying, hurt like hell, and with diarrhoea, stool foul smelling phenomenon, body temperature is 38.1 DEG C after measured, to take after the granule of the embodiment of the present invention 1 the 2nd day, symptom is alleviated gradually, and pain symptom obviously alleviates, continue again to take 4 days transference cures afterwards, return to one's perfect health, reply orthobiosis, within 6 months, Effect of follow-up visit by telephone does not recur.
Case 2: cattle, man, 5 years old, people from Weifang, Shandong, patients acuity diarrhoea, vomiting phenomenon, and with pain, abdominal part color ultrasound finds, mesenteric adenophyma is large, about 3.5cm × 4.1cm, patient mental's state is poor, pain is got up with sweating due to debility, and with fever phenomenon (temperature is 39 DEG C), to take after the granule of the embodiment of the present invention 3 the 5th day, symptom is alleviated gradually, pain symptom obviously alleviates, and continues again to take 5 days transference cures afterwards, returns to one's perfect health, reply orthobiosis, within 6 months, Effect of follow-up visit by telephone does not recur.
Case 3: Ma, female, 2.5 years old, people from Linyi, Shandong, patient is because of belly hurt like hell, and local hospital is diagnosed as adenomesenteritis, and hospitalization 3 days, poor effect, mental status is poor, and pain repeatedly, then my institute's treatment, take the granule of the embodiment of the present invention 2, symptom is alleviated gradually, the mental status is good, and continue again to take disease after 5 days and return to one's perfect health, within 6 months, Effect of follow-up visit by telephone does not recur.
Case 4: permitted certain, man, 4 years old, Jinan, Shandong Province people, patient's hyperpyrexia body temperature is 39.5 DEG C, belly hurt like hell, its father and mother's private prosecution patient causes due to cat fever, with crossing Neopap body-temp. reducing, abdominal part color ultrasound finds lymphadenectasis, be 1.5cm × 2.1cm through abdominal part color ultrasound tumor size, take the granule of the embodiment of the present invention 5, symptom is alleviated gradually, pain symptom obviously alleviates, lymphadenectasis phenomenon disappears substantially, continue again to take 5 days transference cures afterwards, return to one's perfect health, reply orthobiosis, within 6 months, Effect of follow-up visit by telephone does not recur.
Case 5: Jin, female, 9 years old, people from Yantai, Shandong, in December, 2014 came my institute and checks, patient about 3 days adopts traditional Chinese massage treatment, patient pain's number of times increase before a week, and generates heat and be admitted to hospital for 4 days, and thermal spike 39.9 DEG C, therapeutic effect is not good enough.Diarrhoea number of times one day 3-5 time, use montmorillonite powder to be used for antidiarrheal at home, effect is effective for blink, but exacerbation of symptoms after drug effect, suffers from diarrhoea and with pain, the mental status is poor.Adopt after the granule taking the embodiment of the present invention 3 after the 1st course for the treatment of, symptom is alleviated gradually, and the mental status is better, transference cure after 1 course for the treatment of, and after 1 course for the treatment of of SM, return to one's perfect health, within 6 months, Effect of follow-up visit by telephone does not recur.

Claims (10)

1. one kind is used for the treatment of the granule of infantile adenomesenteritis, it is characterized in that, be made up of following crude drug: Herba Houttuyniae, Pollen Pini, Herba Equiseti Hiemalis, Caulis Fibraureae, Cortex Lycii, Radix Puerariae, Fructus Crataegi (parched to brown), Radix Isatidis, Lignum Sappan, Semen Astragali Complanati, Radix Picriae felterrae, Rhizoma Chuanxiong, Radix Paeoniae Alba, Fructus Toosendan, Herba Pogostemonis, Poria, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Folium Ginkgo, Rhizoma Cyperi, Radix Bupleuri.
2. granule according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Herba Houttuyniae 10-15 part, Pollen Pini 10-20 part, Herba Equiseti Hiemalis 8-12 part, Caulis Fibraureae 8-15 part, Cortex Lycii 10-15 part, Radix Puerariae 10-15 part, Fructus Crataegi (parched to brown) 10-30 part, Radix Isatidis 10-20 part, Lignum Sappan 2-15 part, Semen Astragali Complanati 9-18 part, Radix Picriae felterrae 3-10 part, Rhizoma Chuanxiong 8-15 part, Radix Paeoniae Alba 7-14 part, Fructus Toosendan 2-10 part, Herba Pogostemonis 3-8 part, Poria 10-15 part, Radix Glycyrrhizae 2-8 part, Pericarpium Citri Reticulatae 10-15 part, Folium Ginkgo 8-12 part, Rhizoma Cyperi 5-10 part, Radix Bupleuri 10-20 part.
3. granule according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Herba Houttuyniae 12 parts, Pollen Pini 15 parts, Herba Equiseti Hiemalis 10 parts, Caulis Fibraureae 11.5 parts, Cortex Lycii 12 parts, Radix Puerariae 12 parts, Fructus Crataegi (parched to brown) 15 parts, Radix Isatidis 15 parts, Lignum Sappan 8 parts, Semen Astragali Complanati 13 parts, Radix Picriae felterrae 6.5 parts, Rhizoma Chuanxiong 11 parts, Radix Paeoniae Alba 10 parts, Fructus Toosendan 6 parts, Herba Pogostemonis 5 parts, 12 parts, Poria, 5 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 12 parts, Folium Ginkgo 10 parts, Rhizoma Cyperi 7 parts, Radix Bupleuri 15 parts.
4. granule according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Herba Houttuyniae 11 parts, Pollen Pini 14 parts, Herba Equiseti Hiemalis 9 parts, Caulis Fibraureae 10.5 parts, Cortex Lycii 10 parts, Radix Puerariae 11 parts, Fructus Crataegi (parched to brown) 17 parts, Radix Isatidis 14 parts, Lignum Sappan 7 parts, Semen Astragali Complanati 12 parts, Radix Picriae felterrae 5.5 parts, Rhizoma Chuanxiong 10 parts, Radix Paeoniae Alba 9 parts, Fructus Toosendan 5.5 parts, Herba Pogostemonis 4 parts, 11 parts, Poria, 4 parts, Radix Glycyrrhizae, Pericarpium Citri Reticulatae 10 parts, Folium Ginkgo 11 parts, Rhizoma Cyperi 7 parts, Radix Bupleuri 14 parts.
5. prepare a preparation method for granule according to claim 4, it is characterized in that, concrete step is:
(1) Herba Houttuyniae, Pericarpium Citri Reticulatae, Folium Ginkgo, Rhizoma Cyperi, Radix Bupleuri, Cortex Lycii, Herba Equiseti Hiemalis, Radix Isatidis, Rhizoma Chuanxiong and Radix Paeoniae Alba mixing is taken, add 8-10 times of water soaking, then decoct 2 times, 1.5 hours first times, second time 1 hour, merges decoction liquor, filters, being evaporated to relative density is 1.18, for subsequent use;
(2) Pollen Pini, Caulis Fibraureae is taken, Radix Puerariae, Fructus Crataegi (parched to brown), Lignum Sappan, Semen Astragali Complanati, Radix Picriae felterrae, Fructus Toosendan, Herba Pogostemonis, Poria, and Radix Glycyrrhizae mixing, be ground into coarse powder, 13 times of volumetric concentrations are the alcoholic solution reflux, extract, 3 times of 85%, each 2 hours, merge ethanol extract, for subsequent use;
(3) add in the ethanol extract of step (2) by the concentrated solution of step (1), stir, hold over night, centrifugal, supernatant is condensed into extractum, lyophilization after reclaiming ethanol, pulverizes, obtains clear paste powder;
(4) mixed homogeneously with pharmaceutically acceptable adjuvant by step (3) gained clear paste powder, then wet granulation, obtains granule.
6. the preparation method of granule according to claim 5, is characterized in that: described pharmaceutically acceptable adjuvant comprises filler, binding agent; Wherein said filler be sucrose, lactose, mannitol, dextrin one or both, the one of the aqueous solution of 50% alcoholic solution of described binding agent to be agent be 3% hypromellose, the aqueous solution of 10% PVP K30,30% starch slurry and 10% carboxymethyl cellulose.
7. the preparation method of granule according to claim 5, is characterized in that: in step (4), clear paste powder and the weight consumption of pharmaceutically acceptable adjuvant are than being 0.1-0.2:1.
8. the preparation method of granule according to claim 5, is characterized in that: in step (4), clear paste powder and the weight consumption of pharmaceutically acceptable adjuvant are than being 0.15:1.
9. the preparation method of granule according to claim 6, is characterized in that: described filler is selected from the mixture of lactose and dextrin, and described binding agent is selected from 50% alcoholic solution of 3% hypromellose.
10. the granule according to any one of claim 1-9, is characterized in that: the application of described granule in preparation treatment infantile adenomesenteritis medicine.
CN201610014893.4A 2016-01-09 2016-01-09 Granule for treating mesenteric lymphadenitis in children and application thereof Withdrawn CN105456618A (en)

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Publication number Priority date Publication date Assignee Title
CN104367711A (en) * 2014-10-16 2015-02-25 青岛申达高新技术开发有限公司 Pharmaceutical composition for treatment of mesenteric lymphadenitis in children

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Publication number Priority date Publication date Assignee Title
CN104367711A (en) * 2014-10-16 2015-02-25 青岛申达高新技术开发有限公司 Pharmaceutical composition for treatment of mesenteric lymphadenitis in children

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