CN105456336A - Food, health care product or pharmaceutical composition containing gorse and fructus hippophae - Google Patents
Food, health care product or pharmaceutical composition containing gorse and fructus hippophae Download PDFInfo
- Publication number
- CN105456336A CN105456336A CN201510964189.0A CN201510964189A CN105456336A CN 105456336 A CN105456336 A CN 105456336A CN 201510964189 A CN201510964189 A CN 201510964189A CN 105456336 A CN105456336 A CN 105456336A
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- Prior art keywords
- fructus hippophae
- pharmaceutical composition
- gorse
- supernatant
- food
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- 230000035945 sensitivity Effects 0.000 description 1
- 239000011257 shell material Substances 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- UAEJRRZPRZCUBE-UHFFFAOYSA-N trimethoxyalumane Chemical compound [Al+3].[O-]C.[O-]C.[O-]C UAEJRRZPRZCUBE-UHFFFAOYSA-N 0.000 description 1
- 230000001515 vagal effect Effects 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention provides food, a health care product or a pharmaceutical composition containing gorse and fructus hippophae. The raw materials of the food, health care product or pharmaceutical composition comprises the components according to the following weight proportion: gorse to fructus hippophae to snow chrysanthemum is equivalent to (50 to 70):(20 to 40):(5 to 15). Experiments show that the gorse and fructus hippophae have certain anti-tussive activity, but the anti-tussive efficacy of the fructus hippophae is not as good as that of the gorse. However, by combining the gorse, fructus hippophae and snow chrysanthemum for use, under the same crude drug dosage, the efficacy of the composition of the gorse, fructus hippophae and snow chrysanthemum is superior to that of using the gorse singly, the result shows that the composition provided by the invention is proper in formula, a synergistic effect is realized, the anti-tussive activity of each single herb is strengthened, and a new choice is provided for preventing and treating a cough.
Description
Technical field
The invention belongs to field of health care products, be specifically related to a kind of containing cough-relieving food gorsy, health product or pharmaceutical composition.
Technical background
Cough is protective respiratory reflex; when sensor in larynx, trachea and bronchus inwall mucous epithelium is upset; impulsion reaches oblongata by vagal centripetal fiber; then through nervus centrifugalis to the place such as glottis and respiratory muscle; cause a series of coordination and action orderly; be the protective response of the person, the antibacterial entered in tracheobronchial foreign body, lung and disorganization product can be discharged by cough, but frequently violent cough be harmful to the person.The model of action of cough medicine has: 1. local anesthesia antitussive, local anesthesia airway sensor and teleneuron, weakens local irritant effect.2. antiinflammatory antitussive, is reduced inflammation to the stimulation of respiratory tract by antiinflammatory action.3. separate epidemic disease cough-relieving, by alleviating bronchial smooth muscle epidemic disease contraction, reducing alveolar and excessively inflating, alleviate the stimulation of few pulmonary stretch receptor and reach cough-relieving.
Flos Caraganae Sinicae has another name called golden peafowl, Jin Quehua, and belong to pulse family dish flower subfamily Caragana (CaraganachinensisTurcz.exMaxim), nature and flavor tepor is sweet, has effect of YIN nourishing and blood, spleen invigorating.Control consumptive fever cough, the dizzy soreness of waist, women pant leucorrhea, infantile malnutrition, acute mastitis, traumatic injury etc.Current Flos Caraganae Sinicae is mainly used in viewing and admiring, and also have a small amount of edible, but product is not on a large scale, resource utilization is extremely low.The alone antitussive action of Flos Caraganae Sinicae is limited, and the present invention intends developing compound product gorsy, to strengthen product practicality.
Yet there are no the relevant report of Flos Caraganae Sinicae, Fructus Hippophae and snow chrysanthemum conbined usage; After triple combination uses, there is not research to the cough-relieving potency due of component yet.
Summary of the invention
The object of the present invention is to provide a kind of based on compound recipe antitussive composition gorsy.Present invention also offers preparation method and the purposes of said composition.
Particularly, the invention provides a kind of food, health product or pharmaceutical composition containing Flos Caraganae Sinicae, Fructus Hippophae, its raw material is made up of the component of following weight proportion:
Flos Caraganae Sinicae: Fructus Hippophae: snow chrysanthemum=(50 ~ 70): (20 ~ 40): (5 ~ 15).
Further, its raw material is made up of the component of following weight proportion:
Flos Caraganae Sinicae: Fructus Hippophae: snow chrysanthemum=(55 ~ 65): (25 ~ 35): (7 ~ 12).
In the present invention's detailed description of the invention, raw material is used to be made up of the component of following weight proportion:
Flos Caraganae Sinicae: Fructus Hippophae: snow chrysanthemum=60: 30: 10.
The each raw material weight proportioning of the present invention, all calculates with dry product, if fresh goods or moisture product, can convert according to water content.
The fruit that Fructus Hippophae (HippophaerhamnoidesLinn.) is Elaeangnaceae plant Fructus Hippophae, has effect of relieving cough and resolving phlegm, relieving dyspepsia, promoting blood circulation to remove blood stasis.China is the medical history of Fructus Hippophae country the earliest in the world, before 1300 " moon king medicine is precious " of the Tang Dynasty, the Four-Volume Medical Code and the Qing Dynasty " Jingzhubencao " etc. all describe the medical usage of Fructus Hippophae.Fructus Hippophae was also once used as the common drug for the treatment of various diseases by Tibetan medicine, Mongolian medicine.Within 1977, Ministry of Public Health formally lists Fructus Hippophae in Chinese Pharmacopoeia first, and announcement Fructus Hippophae is medicine-food two-purpose kind in succession.Modern chemical composition analysis shows: be rich in vitamin, vitamin 8, carotenoid, several amino acids, linoleic acid and flavone compound in Fructus Hippophae, phospholipids compounds etc., also has the nutritional labeling such as trace element, protein.Wherein Vc content is higher than any one fruit, and the content of Ve and bata-carotene is also far above similar plant.Containing the trace element of 77 kinds of needed by human in sea buckthorn juice, hyperkalemia hyponatremia, without arsenic and cadmium.Wherein higher with the content of calcium, ferrum, zinc, potassium, selenium.Play an important role in the clinical practice in following of these bioactive substances and nutrient substance.
Snow chrysanthemum has another name called the Kunlun snow chrysanthemum, Herba Coreopsis tinctoria, and Compendium of Material Medica calls it can remove wind heat, kidney tonifying nourishing YIN, and with controlling all public attention orders, its purport is profound and subtle.Bencao Jingshu: snow chrysanthemum peace the intestines and stomach, sharp five pulse conditions of ZANG-organs, adjusts extremity, promoting the circulation of QI blood person.Record a lot of about the medical value of snow chrysanthemum in successive dynasties pharmacopeia.The traditional Chinese medical science is thought: the Kunlun snow chrysanthemum is cool in nature, has the effects such as wind and heat dispersing, brain nourishing and eyesight improving, removing toxic substances and promoting subsidence of swelling.And avenge chrysanthemum and have stronger inhibitory action to staphylococcus aureus, diphtheria corynebacterium and dysentery bacterium, therefore have obvious curative effects to pneumonia, rhinitis, bronchitis, laryngopharynx swelling and pain etc., there is effect of sterilization, antibacterial, antiinflammatory, preventing cold and chronic enteritis.
Wherein, described compositions is oral administration dosage form.
Further, described oral administration dosage form is selected from oral liquid, syrup, granule, powder, medicinal tea, pill, tablet or capsule.
For in the solid dosage forms of oral administration, active component mixes with at least one conventional inert excipients (or carrier), as sodium citrate or dicalcium phosphate, or mix with following compositions: (a) filler or bulking agent, such as, starch, lactose, sucrose, glucose, mannitol and silicic acid; (b) binding agent, such as, hydroxy methocel, alginate, gelatin, polyvinyl pyrrolidone, sucrose and arabic gum; (c) wetting agent, such as, glycerol; (d) disintegrating agent, such as, agar, calcium carbonate, potato starch or tapioca, alginic acid, some composition silicate and sodium carbonate; (e) retarding solvent, such as paraffin; F () absorbs accelerator, such as, and quaternary ammonium compound; (g) wetting agent, such as spermol and glyceryl monostearate; (h) adsorbent, such as, Kaolin; (i) lubricant, such as, Talcum, calcium stearate, magnesium stearate, solid polyethylene glycol, sodium lauryl sulphate, or its mixture.In capsule, tablet and pill, dosage form also can comprise buffer agent.
Solid dosage forms such as tablet, sugar pill, capsule, pill and granule can adopt coating and the preparation of shell material, as casing and other material well known in the art.They can comprise opacifying agent, and in this compositions, the release of active component can discharge in certain part in a delayed fashion in digestive tract.The example of adoptable embedding component is polymeric material and Wax.If desired, active component also can form microencapsulation form with one or more in above-mentioned excipient.
For the liquid dosage form of oral administration, except active component, liquid dosage form can comprise the conventional inert diluent adopted in this area, as water or other solvent, solubilizing agent and emulsifying agent, such as, ethanol, isopropyl alcohol, ethyl carbonate, ethyl acetate, propylene glycol, 1, the mixture etc. of 3-butanediol, dimethyl formamide and oil, particularly Oleum Gossypii semen, Oleum Arachidis hypogaeae semen, maize embryo oil, olive oil, Oleum Ricini and Oleum sesami or these materials.
Except these inert diluents, compositions also can comprise auxiliary agent, as wetting agent, emulsifying agent and suspending agent, sweeting agent, correctives and spice.
Except active component, suspension can comprise suspending agent, such as, and the mixture etc. of ethoxylation isooctadecane alcohol, polyoxyethylene sorbitol and Isosorbide Dinitrate, microcrystalline Cellulose, aluminium methoxide and agar or these materials.
Compositions for parenteral injection can comprise physiologically acceptable sterile, aqueous or anhydrous solution, dispersion liquid, suspension or emulsion, and for being again dissolved into aseptic Injectable solution or the sterilized powder of dispersion liquid.Suitable moisture and nonaqueous carrier, diluent, solvent or excipient comprise water, ethanol, polyhydric alcohol and suitable mixture thereof.
Dosage form for the compounds of this invention of topical comprises ointment, powder, patch, propellant and inhalant.Active component aseptically with physiologically acceptable carrier and any antiseptic, buffer agent, or the propellant that may need if desired is mixed together.
Wherein, sucrose, antiseptic is contained in described syrup.
Present invention also offers the preparation method of above-mentioned syrup, it comprises following operating procedure:
(1) according to claims 1 to 3 proportion relation, get the 1000g mixing altogether of Flos Caraganae Sinicae, Fructus Hippophae, snow chrysanthemum, decoct with water, merging filtrate, gets supernatant after staticly settling, and obtains the first supernatant, again by the first supernatant concentrating under reduced pressure, staticly settle, again draw obtain the second supernatant;
(2) in the second supernatant, add simple syrup 400mL, appropriate antiseptic, boils after mix homogeneously, and adding distil water, to 1500mL, stirs evenly and obtains syrup.
Further, foregoing preservatives is selected from one or both the combination in sodium benzoate, ethyl hydroxybenzoate.
Present invention also offers above-mentioned composition and prepare the purposes in cough suppressing medicine, health product or food.
The present invention's experiment shows Flos Caraganae Sinicae, Fructus Hippophae has certain antitussive activity, but Fructus Hippophae cough-relieving effect is not as good as Flos Caraganae Sinicae.But, the present invention by Flos Caraganae Sinicae and Fructus Hippophae, avenge after chrysanthemum compatibility uses, under identical crude drug dosage, its compositions cough-relieving effect is but better than alone Flos Caraganae Sinicae or other two tastes components, illustrate that present composition formula is appropriate, play synergistic function, enhanced the antitussive activity of each single medicinal material, for prevention or treatment cough provide new selection.
Obviously, according to foregoing of the present invention, according to ordinary technical knowledge and the means of this area, not departing under the present invention's above-mentioned basic fundamental thought prerequisite, the amendment of other various ways, replacement or change can also be made.
Below by way of the form of specific embodiment, foregoing of the present invention is described in further detail again.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment.All technology realized based on foregoing of the present invention all belong to scope of the present invention.
Detailed description of the invention
Embodiment 1: the preparation of the present composition
Get Flos Caraganae Sinicae, Fructus Hippophae and snow chrysanthemum 1000g altogether, three's weight ratio is 60: 30: 10 (all calculating by dry product), add the distilled water of mixture total weight amount 6 ~ 10 times, heating decoction 1 ~ 3 time, filters after decocting 1 ~ 2h at every turn, merges filtrate, filtrate after merging is staticly settled rear Aspirate supernatant, obtain the first supernatant, then by the first supernatant concentrating under reduced pressure, staticly settle, again draw obtain the second supernatant; In the second supernatant, add simple syrup 400mL, sodium benzoate 0.12g, ethyl hydroxybenzoate 0.15g, boil after mix homogeneously, adding distil water, to 1500mL, stirs evenly and obtains Flos Caraganae Sinicae cough syrup.
Embodiment 2: the preparation of the present composition
Get Flos Caraganae Sinicae, Fructus Hippophae and snow chrysanthemum, three's weight ratio is 70: 20: 10 (all calculating by dry product), after mixing, use 70%v/v ethanol, water reflux, extract, 2 times successively, each 40min, ethanol extract reclaims after ethanol and merges with Aqueous extracts, concentrates, and adds appropriate dextrin and microcrystalline Cellulose prepares granule.
Embodiment 3: the preparation of the present composition
Get Flos Caraganae Sinicae, Fructus Hippophae and snow chrysanthemum, three's weight ratio is 55: 35: 10 (all calculating by dry product), and after drying, mixing, prepares teabag.
Embodiment 4 present composition antitussive action is tested
1) Experimental agents:
A group: get Flos Caraganae Sinicae, Fructus Hippophae and snow chrysanthemum 1000g altogether, three's weight ratio is 60: 30: 10 (all calculating by dry product), add the distilled water of mixture total weight amount 6 ~ 10 times, heating decoction 1 ~ 3 time, filters after decocting 1 ~ 2h at every turn, merges filtrate, filtrate after merging is staticly settled rear Aspirate supernatant, obtain the first supernatant, then by the first supernatant concentrating under reduced pressure, staticly settle, again draw obtain the second supernatant; In the second supernatant, add simple syrup 400mL, sodium benzoate 0.12g, ethyl hydroxybenzoate 0.15g, boil after mix homogeneously, adding distil water, to 1500mL, stirs evenly and obtains Flos Caraganae Sinicae cough syrup A.
B group: get Flos Caraganae Sinicae 1000g, add the distilled water of gross weight 6 ~ 10 times, heating decoction 1 ~ 3 time, filter after each decoction 1 ~ 2h, merge filtrate, the filtrate after merging is staticly settled rear Aspirate supernatant, obtains the first supernatant, again by the first supernatant concentrating under reduced pressure, staticly settle, again draw obtain the second supernatant; In the second supernatant, add simple syrup 400mL, sodium benzoate 0.12g, ethyl hydroxybenzoate 0.15g, boil after mix homogeneously, adding distil water, to 1500mL, stirs evenly and obtains cough syrup B.
C group: get Fructus Hippophae 1000g, add the distilled water of gross weight 6 ~ 10 times, heating decoction 1 ~ 3 time, filter after each decoction 1 ~ 2h, merge filtrate, the filtrate after merging is staticly settled rear Aspirate supernatant, obtains the first supernatant, again by the first supernatant concentrating under reduced pressure, staticly settle, again draw obtain the second supernatant; In the second supernatant, add simple syrup 400mL, sodium benzoate 0.12g, ethyl hydroxybenzoate 0.15g, boil after mix homogeneously, adding distil water, to 1500mL, stirs evenly and obtains cough syrup C.
D group: get the Kunlun snow chrysanthemum 1000g, add the distilled water of gross weight 6 ~ 10 times, heating decoction 1 ~ 3 time, filter after each decoction 1 ~ 2h, merge filtrate, the filtrate after merging is staticly settled rear Aspirate supernatant, obtains the first supernatant, again by the first supernatant concentrating under reduced pressure, staticly settle, again draw obtain the second supernatant; In the second supernatant, add simple syrup 400mL, sodium benzoate 0.12g, ethyl hydroxybenzoate 0.15g, boil after mix homogeneously, adding distil water, to 1500mL, stirs evenly and obtains syrup D.
2) experimentation
Strong aqua ammonia is a kind of chemicals of irritant abnormal smells from the patient, after animal sucks, stimulates airway sensor, just causes cough.Thus, as long as the medicine of coughing centre or reduction airway sensor sensitivity can be suppressed all to have antitussive action.This experiment is by allowing mice suck after ammonia causes and cough, and this formula of gavage extract is to observe antitussive action.
1, strong aqua ammonia nebulization research almond perilla anti-cough syrup antitussive effect
Kunming mouse, body weight 18 ~ 22g, male and female half and half, put in 4L closed glass case, evenly spraying strong aqua ammonia aerosol with ultrasound atomizer to constant voltage in case, take out immediately after 5s, to magnify with mice contraction of abdominal muscle or with coughing sound for index simultaneously, observe and record cough number of times in mouse cough incubation period (to cough required time by spraying ammonia) and 2min, after spraying, 2min not cough person abandons.Qualified mice random packet after 2 days.
Qualified mice 70, arranges the high, medium and low dosage group of 7 groups: A cough syrup, matched group (normal saline group) and B, C, D cough syrup group.Every Mus gives medicinal liquid or normal saline by 0.2mL/10g, once a day, continuous 7 days, after last administration, mice is put in closed glass case by 1h respectively, and evenly spray strong aqua ammonia aerosol with ultrasound atomizer to constant voltage in case, spray time is about 10s, spouting liquid is about 3mL, cause mouse cough to react, record mice occur cough time and 2min in mouse cough number of times, test data represents with mean ± standard deviation.
4) pharmaceutical composition of the present invention is to the result of mice antitussive action
Result of the test shows that the middle and high dosage group of almond perilla anti-cough syrup can obviously reduce mouse cough number of times; Meanwhile, high dose group, middle dosage group obviously can extend mice and draw and cough incubation period.In table 1.
The each syrup group of table 1 causes the impact of the mice antitussive action of cough on ammonia
Compared with blank group, *: p < 0.05; *: p < 0.01.
As shown in Table 1, in pharmaceutical composition of the present invention, high dose group has antitussive action to the mouse cough that ammonia causes, and in certain dose-effect relationship, have significantly (p < 0.05) or pole significant difference (p < 0.01) with blank group.
In addition, the Flos Caraganae Sinicae of same concentrations, Fructus Hippophae or snow chrysanthemum is used alone, although there is the effect of cough-relieving, but its antitussive action is obviously not as good as the combination of three, after this also proves that Flos Caraganae Sinicae, Fructus Hippophae and snow chrysanthemum use by the present invention, played synergistic function, antitussive action gets a promotion.
Claims (9)
1. the food containing Flos Caraganae Sinicae, Fructus Hippophae, health product or a pharmaceutical composition, is characterized in that: its raw material is made up of the component of following weight proportion:
Flos Caraganae Sinicae: Fructus Hippophae: snow chrysanthemum=(50 ~ 70): (20 ~ 40): (5 ~ 15).
2. food according to claim 1, health product or pharmaceutical composition, is characterized in that: its raw material is made up of the component of following weight proportion:
Flos Caraganae Sinicae: Fructus Hippophae: snow chrysanthemum=(55 ~ 65): (25 ~ 35): (7 ~ 12).
3. food according to claim 2, health product or pharmaceutical composition, is characterized in that: its raw material is made up of the component of following weight proportion:
Flos Caraganae Sinicae: Fructus Hippophae: snow chrysanthemum=60: 30: 10.
4. the food according to claims 1 to 3 any one, health product or pharmaceutical composition, is characterized in that: described compositions is oral administration dosage form.
5. food according to claim 4, health product or pharmaceutical composition, is characterized in that: described oral administration dosage form is selected from oral liquid, syrup, granule, powder, medicinal tea, pill, tablet or capsule.
6. food according to claim 5, health product or pharmaceutical composition, is characterized in that: also containing sucrose, antiseptic in described syrup.
7. the preparation method of syrup described in claim 5 or 6, is characterized in that: it comprises following operating procedure:
(1) according to claims 1 to 3 proportion relation, get the 1000g mixing altogether of Flos Caraganae Sinicae, Fructus Hippophae, snow chrysanthemum, decoct with water, merging filtrate, gets supernatant after staticly settling, and obtains the first supernatant, again by the first supernatant concentrating under reduced pressure, staticly settle, again draw obtain the second supernatant;
(2) in the second supernatant, add simple syrup 400mL, appropriate antiseptic, boils after mix homogeneously, and adding distil water, to 1500mL, stirs evenly and obtains syrup.
8. preparation method according to claim 7, is characterized in that: described antiseptic is selected from one or both the combination in sodium benzoate, ethyl hydroxybenzoate.
9. compositions described in claim 1 ~ 6 any one is preparing the purposes in cough suppressing medicine, health product or food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510964189.0A CN105456336A (en) | 2015-12-22 | 2015-12-22 | Food, health care product or pharmaceutical composition containing gorse and fructus hippophae |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510964189.0A CN105456336A (en) | 2015-12-22 | 2015-12-22 | Food, health care product or pharmaceutical composition containing gorse and fructus hippophae |
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| Publication Number | Publication Date |
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| CN105456336A true CN105456336A (en) | 2016-04-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510964189.0A Pending CN105456336A (en) | 2015-12-22 | 2015-12-22 | Food, health care product or pharmaceutical composition containing gorse and fructus hippophae |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105456336A (en) |
-
2015
- 2015-12-22 CN CN201510964189.0A patent/CN105456336A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 郭国华: "《临床中药辞典》", 30 September 1994, 湖南科学技术出版社 * |
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Application publication date: 20160406 |