CN105434484A - Preparation method of ephedra decoction pieces with diuresis and edema elimination functions - Google Patents

Preparation method of ephedra decoction pieces with diuresis and edema elimination functions Download PDF

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Publication number
CN105434484A
CN105434484A CN201510822682.9A CN201510822682A CN105434484A CN 105434484 A CN105434484 A CN 105434484A CN 201510822682 A CN201510822682 A CN 201510822682A CN 105434484 A CN105434484 A CN 105434484A
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herba ephedrae
decoction pieces
preparation
ephedra
manufacture method
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CN201510822682.9A
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包勇
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Qianfang Chinese Medicines Development Co Ltd Ningguo
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Qianfang Chinese Medicines Development Co Ltd Ningguo
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a preparation method of ephedra decoction pieces with diuresis and edema elimination functions and relates to the technical field of processing of traditional Chinese medicine decoction pieces. The preparation method comprises steps as follows: purification and cleaning of ephedra, low-temperature microwave drying and sterilization, enzymolysis, addition of vinegar and a complex nutrient solution, airing, grinding, preparation and the like. According to the preparation method, the production efficiency is high, energy is saved, and the qualification rate is high; with the adoption of the preparation method, the efficacy of lung freeing, asthma relieving, diuresis and edema elimination of ephedra is improved; the ephedra decoction pieces can be used for treating diseases and symptoms such as wind cold, chest distress, dyspnea with coughing, edema, bronchial asthma and the like. With the adoption of the preparation method, active ingredients of ephedra can be effectively dissolved out, and the toxic and side effects of ephedra are greatly reduced.

Description

A kind of manufacture method of Herba Ephedrae decoction pieces of inducing diuresis to remove edema
Technical field
The present invention relates to Technique for producing medicinal herbs in small pieces field, be specifically related to a kind of manufacture method of Herba Ephedrae decoction pieces of inducing diuresis to remove edema.
Background technology
In Chinese Traditional Medicine, because Chinese crude drug is mostly crude drug, many with earth and other foreign bodies, or have abnormal flavour, or it is toxic, or humidity is unsuitable for preservation etc., can reach through certain process of preparing Chinese medicine process make that medical material is pure, taste masking, reduction toxicity and dry and stay-in-grade object additionally by the process of preparing Chinese medicine of some Chinese crude drug not only being changed to the property of medicine, but also can improve drug effect.For Chinese crude drug Radix Et Rhizoma Rhei, Radix Et Rhizoma Rhei is cold in nature, bitter in the mouth, enter spleen, stomach, liver, large intestine, pericardium channel, there are the multiple efficacies such as stasis removing, purging fire and cooling blood, blood circulation promoting and blood stasis dispelling, promoting the function of the gallbladder to alleviate jaundice, can be used for the treatment of the various disease conditions such as constipation with heat retention, bleeding due to blood-heat, stagnant, the jaundice due to damp-heat of blood stasis knot, calculus internal resistance.The concocting method of the Radix et Rhizoma Rhei (stir-fried with wine) recorded in version pharmacopeia in 2010 appendix II D runs through in rearmounted pot with yellow wine to use slow fire fried dry, dries after taking-up.And fry to anhydrous and be divided into standard, be difficult to control to the process of preparing Chinese medicine completely and again effective degree, thus also result in the insecurity of medication.
Herba Ephedrae is the dry herb stem of Ephedraceae plant plait Herba Ephedrae, epheday intermedia or ephedra equisetina; Tap green herb stem autumn, dry; It is warm in nature, and acrid in the mouth, micro-hardship, have effect of diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema, can treat anemofrigid cold, the diseases such as edema due to wind pathogen edema, bronchial asthma of breathing with cough uncomfortable in chest; At present, the process of preparing Chinese medicine of Herba Ephedrae, for picking decontamination, washes, and soaks, pulls out and run through, slightly smile to crust without soapy feeling time, then after moistening, chip drying.
In prior art, the making of Herba Ephedrae produces to belong to workshop-based more, cannot meet the requirement of large production standard; In traditional handicraft, factor controls with the experience of operator full the duration and degree of heating, temperature, time etc., and difficulty is large, and product quality usually can be uneven because operator is different; During operation, flue dust is large, pollutes working environment; Operating time is long, and energy consumption is large.
Summary of the invention
(1) technical problem solved
Not enough for prior art, the manufacture method manufacture method time that the invention provides a kind of Herba Ephedrae decoction pieces of inducing diuresis to remove edema is short, and production efficiency is high, energy savings, and qualification rate is high; And manufacture method of the present invention enhances the depressed lung-energy dispersing of Herba Ephedrae, effect of inducing diuresis to remove edema.
(2) technical scheme
For realizing above object, the present invention is achieved by the following technical programs:
A manufacture method for the Herba Ephedrae decoction pieces of inducing diuresis to remove edema, comprises the following steps:
S1, get fresh Herba Ephedrae, decontamination is cleaned, and then adds deionized water by the material-water ratio of 1:4-6, is heated to 45-50 DEG C, soaks after 5-7 hour, takes out to insert in microwave low-temperature drying bactericidal unit to be dried to moisture content 15-30%;
S2, preparation enzymolysis solution, with 100g clear water for benchmark, add cellulase 1.5g, hemicellulase 1.0g makes enzymolysis solution; Then put into wherein by the Herba Ephedrae after above-mentioned steps S1 sterilization treatment, enzymolysis 20-25 minute, control temperature 60-70 DEG C, takes out after enzymolysis, dries;
S3, add a certain amount of tablet vinegar mix thoroughly to the Herba Ephedrae after step S2 dries, steam 2-3h with moderate heat, taking-up is dried; Then add the composite nutrient-fluid of the 15-20% of Herba Ephedrae quality, mix homogeneously, be heated to 65-75 DEG C, soak 30-45 minute, taking-up is dried;
S4, step S3 is dried after Herba Ephedrae roll with cylinder, roll 60-80s, be rolled into the thin slice that thickness is 2-6mm;
S4, the Herba Ephedrae thin slice after compressing, with punch press, the punching of Herba Ephedrae thin slice is become the Herba Ephedrae decoction pieces of various shape; Finally new shape Herba Ephedrae decoction pieces is placed and dry in an oven, to obtain final product.
Preferably, the microwave frequency of microwave low-temperature drying sterilizing described in step S1 is 500MHz ~ 100GHz, and temperature controls at 35 ~ 45 DEG C, sterilizing 10 ~ 12 minutes.
Preferably, composite nutrient-fluid described in step S3 is Herba Asari extract, Rhizoma Pinelliae extract, citric acid, potassium sorbate, vitamin c three kinds or four kinds of mixing.
Preferably, composite nutrient-fluid described in step S3 is four kinds or five kinds of mixing in Rhizoma Zingiberis Recens extract, Rhizoma Atractylodis Macrocephalae extract, Radix Glycyrrhizae extract, Fructus Citri Limoniae juice, lecithin, potassium sorbate, vitamin c.
Preferably, microwave low-temperature drying sterilizing described in step S1 is-1 ~-3 DEG C.
(3) beneficial effect
The invention provides a kind of manufacture method of Herba Ephedrae decoction pieces of inducing diuresis to remove edema, the manufacture method time of the present invention is short, and production efficiency is high, energy savings, and qualification rate is high, and production cost reduces, and economic benefit increases; And making of the present invention enhances the depressed lung-energy dispersing of Herba Ephedrae, effect of inducing diuresis to remove edema; Can treat anemofrigid cold, the diseases such as edema due to wind pathogen edema, bronchial asthma of breathing with cough uncomfortable in chest, manufacture method of the present invention can enable the active component effectively stripping of Herba Ephedrae, greatly reduces the toxic and side effects of itself.
Detailed description of the invention
For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1:
The manufacture method of the Herba Ephedrae decoction pieces of the present embodiment inducing diuresis to remove edema, comprises the following steps:
S1, get fresh Herba Ephedrae, decontamination is cleaned, and then adds deionized water by the material-water ratio of 1:4, is heated to 45 DEG C, soaks after 5 hours, takes out to insert in microwave low-temperature drying bactericidal unit to be dried to moisture content 15-30%;
S2, preparation enzymolysis solution, with 100g clear water for benchmark, add cellulase 1.5g, hemicellulase 1.0g makes enzymolysis solution; Then put into wherein by the Herba Ephedrae after above-mentioned steps S1 sterilization treatment, enzymolysis 20 minutes, control temperature 60 DEG C, takes out after enzymolysis, dries;
S3, add a certain amount of tablet vinegar mix thoroughly to the Herba Ephedrae after step S2 dries, steam 2h with moderate heat, taking-up is dried; Then add the composite nutrient-fluid of 15% of Herba Ephedrae quality, mix homogeneously, be heated to 65 DEG C, soak 30 minutes, taking-up is dried;
S4, step S3 is dried after Herba Ephedrae roll with cylinder, roll 60s, be rolled into the thin slice that thickness is 2-3mm;
S4, the Herba Ephedrae thin slice after compressing, with punch press, the punching of Herba Ephedrae thin slice is become the Herba Ephedrae decoction pieces of various shape; Finally new shape Herba Ephedrae decoction pieces is placed and dry in an oven, to obtain final product.
Embodiment 2:
The manufacture method of the Herba Ephedrae decoction pieces of the present embodiment inducing diuresis to remove edema, comprises the following steps:
S1, get fresh Herba Ephedrae, decontamination is cleaned, and then adds deionized water by the material-water ratio of 1:5, is heated to 48 DEG C, soaks after 6 hours, takes out to insert in microwave low-temperature drying bactericidal unit to be dried to moisture content 15-30%;
S2, preparation enzymolysis solution, with 100g clear water for benchmark, add cellulase 1.5g, hemicellulase 1.0g makes enzymolysis solution; Then put into wherein by the Herba Ephedrae after above-mentioned steps S1 sterilization treatment, enzymolysis 22 minutes, control temperature 65 DEG C, takes out after enzymolysis, dries;
S3, add a certain amount of tablet vinegar mix thoroughly to the Herba Ephedrae after step S2 dries, steam 2.5h with moderate heat, taking-up is dried; Then add the composite nutrient-fluid of 17% of Herba Ephedrae quality, mix homogeneously, be heated to 70 DEG C, soak 35 minutes, taking-up is dried;
S4, step S3 is dried after Herba Ephedrae roll with cylinder, roll 70s, be rolled into the thin slice that thickness is 2-5mm;
S4, the Herba Ephedrae thin slice after compressing, with punch press, the punching of Herba Ephedrae thin slice is become the Herba Ephedrae decoction pieces of various shape; Finally new shape Herba Ephedrae decoction pieces is placed and dry in an oven, to obtain final product.
Embodiment 3:
The manufacture method of the Herba Ephedrae decoction pieces of the present embodiment inducing diuresis to remove edema, comprises the following steps:
S1, get fresh Herba Ephedrae, decontamination is cleaned, and then adds deionized water by the material-water ratio of 1:6, is heated to 50 DEG C, soaks after 7 hours, takes out to insert in microwave low-temperature drying bactericidal unit to be dried to moisture content 15-30%;
S2, preparation enzymolysis solution, with 100g clear water for benchmark, add cellulase 1.5g, hemicellulase 1.0g makes enzymolysis solution; Then put into wherein by the Herba Ephedrae after above-mentioned steps S1 sterilization treatment, enzymolysis 25 minutes, control temperature 70 DEG C, takes out after enzymolysis, dries;
S3, add a certain amount of tablet vinegar mix thoroughly to the Herba Ephedrae after step S2 dries, steam 3h with moderate heat, taking-up is dried; Then add the composite nutrient-fluid of 20% of Herba Ephedrae quality, mix homogeneously, be heated to 75 DEG C, soak 45 minutes, taking-up is dried;
S4, step S3 is dried after Herba Ephedrae roll with cylinder, roll 80s, be rolled into the thin slice that thickness is 6mm;
S4, the Herba Ephedrae thin slice after compressing, with punch press, the punching of Herba Ephedrae thin slice is become the Herba Ephedrae decoction pieces of various shape; Finally new shape Herba Ephedrae decoction pieces is placed and dry in an oven, to obtain final product.
It should be noted that, in this article, the such as relational terms of first and second grades and so on is only used for an entity or operation to separate with another entity or operating space, and not necessarily requires or imply the relation that there is any this reality between these entities or operation or sequentially.And, term " comprises ", " comprising " or its any other variant are intended to contain comprising of nonexcludability, thus make to comprise the process of a series of key element, method, article or equipment and not only comprise those key elements, but also comprise other key elements clearly do not listed, or also comprise by the intrinsic key element of this process, method, article or equipment.When not more restrictions, the key element limited by statement " comprising ... ", and be not precluded within process, method, article or the equipment comprising described key element and also there is other identical element.
Above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit, although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.

Claims (5)

1. a manufacture method for the Herba Ephedrae decoction pieces of inducing diuresis to remove edema, is characterized in that, comprise the following steps:
S1, get fresh Herba Ephedrae, decontamination is cleaned, and then adds deionized water by the material-water ratio of 1:4-6, is heated to 45-50 DEG C, soaks after 5-7 hour, takes out to insert in microwave low-temperature drying bactericidal unit to be dried to moisture content 15-30%;
S2, preparation enzymolysis solution, with 100g clear water for benchmark, add cellulase 1.5g, hemicellulase 1.0g makes enzymolysis solution; Then put into wherein by the Herba Ephedrae after above-mentioned steps S1 sterilization treatment, enzymolysis 20-25 minute, control temperature 60-70 DEG C, takes out after enzymolysis, dries;
S3, add a certain amount of tablet vinegar mix thoroughly to the Herba Ephedrae after step S2 dries, steam 2-3h with moderate heat, taking-up is dried; Then add the composite nutrient-fluid of the 15-20% of Herba Ephedrae quality, mix homogeneously, be heated to 65-75 DEG C, soak 30-45 minute, taking-up is dried;
S4, step S3 is dried after Herba Ephedrae roll with cylinder, roll 60-80s, be rolled into the thin slice that thickness is 2-6mm;
S4, the Herba Ephedrae thin slice after compressing, with punch press, the punching of Herba Ephedrae thin slice is become the Herba Ephedrae decoction pieces of various shape; Finally new shape Herba Ephedrae decoction pieces is placed and dry in an oven, to obtain final product.
2. the manufacture method of the Herba Ephedrae decoction pieces of inducing diuresis to remove edema according to claim 1, is characterized in that, the microwave frequency of microwave low-temperature drying sterilizing described in step S1 is 500MHz ~ 100GHz, and temperature controls at 35 ~ 45 DEG C, sterilizing 10 ~ 12 minutes.
3. the manufacture method of the Herba Ephedrae decoction pieces of inducing diuresis to remove edema according to claim 1, is characterized in that, composite nutrient-fluid described in step S3 is Herba Asari extract, Rhizoma Pinelliae extract, citric acid, potassium sorbate, vitamin c three kinds or four kinds of mixing.
4. the manufacture method of the Herba Ephedrae decoction pieces of inducing diuresis to remove edema according to claim 1, it is characterized in that, composite nutrient-fluid described in step S3 is four kinds or five kinds of mixing in Rhizoma Zingiberis Recens extract, Rhizoma Atractylodis Macrocephalae extract, Radix Glycyrrhizae extract, Fructus Citri Limoniae juice, lecithin, potassium sorbate, vitamin c.
5. the manufacture method of the Herba Ephedrae decoction pieces of inducing diuresis to remove edema according to claim 1, is characterized in that, microwave low-temperature drying sterilizing described in step S1 is-1 ~-3 DEG C.
CN201510822682.9A 2015-11-23 2015-11-23 Preparation method of ephedra decoction pieces with diuresis and edema elimination functions Withdrawn CN105434484A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110193032A (en) * 2019-06-26 2019-09-03 甘肃省和顺元中药饮片有限公司 A kind of concocting method of Chinese ephedra medicine materical crude slice

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110193032A (en) * 2019-06-26 2019-09-03 甘肃省和顺元中药饮片有限公司 A kind of concocting method of Chinese ephedra medicine materical crude slice

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