CN105434460A - Medical pure sodium bicarbonate dialysis dry powder - Google Patents
Medical pure sodium bicarbonate dialysis dry powder Download PDFInfo
- Publication number
- CN105434460A CN105434460A CN201510904019.3A CN201510904019A CN105434460A CN 105434460 A CN105434460 A CN 105434460A CN 201510904019 A CN201510904019 A CN 201510904019A CN 105434460 A CN105434460 A CN 105434460A
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- Prior art keywords
- component
- dry powder
- medical pure
- sodium bicarbonate
- bicarbonate dialysis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
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Abstract
The invention relates to medical pure sodium bicarbonate dialysis dry powder prepared from a component A and a component B. The component A is prepared from, by weight, 10-30% of sodium diacetate, 20-40% of glucose, 40-60% of sodium chloride, 5-30% of potassium chloride, 1-5% of magnesium chloride and 1-5% of calcium chloride. The medical pure sodium bicarbonate dialysis dry powder is easy and safe to use, has the anticoagulation characteristic and is free of adverse reactions and short and long-term complications caused by acetic acid.
Description
Technical field
The present invention relates to a kind of hemodialysis product, be specifically related to a kind of medical pure bicarbonate dialysis dry powder.
Background technology
The primary treatments of current renal failure adopts hemodialysis, and hemodialysis is use bicarbonate dialysis liquid system now substantially.Hemodialysis dry powder (being called for short hemodialysis dry powder) is the concentrate formulation for preparing dialysis solution, is made up of component A and B component.Component A forms primarily of sodium chloride, potassium chloride, calcium chloride, magnesium chloride and acidity regulator (organic acid).B component is made up of sodium bicarbonate or sodium bicarbonate and sodium chloride.During use, component A and B component are dissolved into A, B concentrated solution with reverse osmosis water respectively, draw A, B concentrated solution and reverse osmosis water be in proportion respectively mixed with dialysis solution carry out hemodialysis on dialyser by haemodialysis control unit.
Hemodialysis dry powder in the market or hemodialysis concentrated solution mainly adopt acetic acid that biocompatibility is good as acidity regulator.Due to when production hemodialysis dry powder, liquid freon acetic acid volatility is large, is unfavorable for the improvement of production environment, is difficult to again mix homogeneously, deposits process Solid-liquid demixing with other components.In addition, hemodialysis dry powder is in prolonged storage, and acetic acid can penetrate plastic bag film volatilization loss, thus reduces the regulating power of acidity, affects result of use.Therefore, some producer, when production hemodialysis dry powder, does not add acetic acid, and just adds when preparing dialysis solution in clinical hospitals in component A, so namely adds the trouble of hospital's preparation, too increases the chance that preparation dialysis solution is made mistakes.
Summary of the invention
The object of this invention is to provide a kind of medical pure bicarbonate dialysis dry powder, its stable performance, Clinical practice is convenient.
Medical pure bicarbonate dialysis dry powder of the present invention, a kind of medical pure bicarbonate dialysis dry powder, be made up of component A and B component, described component A comprises the component of following percentage by weight:
Wherein, SDA can be 12%, 15%, 16%, 18%, 20%, 22%, 24%, 25%, 26%, 27%, 28% or 29%;
Glucose can be 22%, 23%, 24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38% or 39%;
Sodium chloride can be 41%, 42%, 43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58% or 59%;
Potassium chloride can be 6%, 8%, 10%, 12%, 15%, 18%, 20%, 22%, 23%, 25%, 28% or 29%;
Magnesium chloride can be 1.2%, 1.5%, 1.8%, 2.0%, 2.2%, 2.3%, 2.5%, 2.8%, 3.0%, 3.3%, 3.5%, 3.8%, 4.0%, 4.3%, 4.5%, 4.8% or 5.0%;
Calcium chloride can be 1.2%, 1.5%, 1.8%, 2.0%, 2.2%, 2.3%, 2.5%, 2.8%, 3.0%, 3.3%, 3.5%, 3.8%, 4.0%, 4.3%, 4.5%, 4.8% or 5.0%.
Preferably, described component A comprises the component of following percentage by weight:
Preferably, described B component is made up of sodium bicarbonate, the quality of described sodium bicarbonate: quality=0.1 ~ 1 of sodium chloride in component A, is preferably 0.1 ~ 0.5, more preferably 0.4.
The using method of medical pure bicarbonate dialysis dry powder of the present invention is: component A reverse osmosis water is dissolved into 5 ~ 6L, obtains A dialysis concentrated solution; B component reverse osmosis water is dissolved into 6.5 ~ 10.0L, obtains B dialysis concentrated solution.Haemodialysis control unit is drawn dialyse concentrated solution and B of A by a certain percentage and to be dialysed concentrated solution be diluted to dialysis solution with reverse osmosis water and use.
Compared with prior art, the invention has the advantages that: medical pure bicarbonate dialysis dry powder of the present invention not containing liquid freon acetic acid, thus overcomes the many harmful effects of use liquid freon acetic acid in dialysis dry powder production, storage process.Replace liquid freon acetic acid in the production process of hemodialysis dry powder with solid SDA, can be mixed together evenly with other salts, production operation is easy, and quality easily controls.
In a word, medical pure bicarbonate dialysis dry powder of the present invention uses simple and safe, has both had anticoagulant characteristic, the untoward reaction caused without acetic acid again and nearly long term complication.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1
The medical pure bicarbonate dialysis dry powder of the present embodiment, is made up of component A and B component.
Wherein, component A comprises the component of following percentage by weight:
B component comprises the component of following percentage by weight: sodium bicarbonate, the weight of sodium bicarbonate: weight=0.1 of sodium chloride.
Embodiment 2
The medical pure bicarbonate dialysis dry powder of the present embodiment, is made up of component A and B component.
Wherein, component A comprises the component of following percentage by weight:
B component comprises the component of following percentage by weight: sodium bicarbonate, the weight of sodium bicarbonate: weight=0.4 of sodium chloride.
Embodiment 3
The medical pure bicarbonate dialysis dry powder of the present embodiment, is made up of component A and B component.
Wherein, component A comprises the component of following percentage by weight:
B component comprises the component of following percentage by weight: sodium bicarbonate, the weight of sodium bicarbonate: weight=1 of sodium chloride.
Above content is only preferred embodiment of the present invention, and for those of ordinary skill in the art, according to thought of the present invention, all will change in specific embodiments and applications, this description should not be construed as limitation of the present invention.
Claims (6)
1. a medical pure bicarbonate dialysis dry powder, is made up of component A and B component, it is characterized in that: described component A comprises the component of following percentage by weight:
2. medical pure bicarbonate dialysis dry powder according to claim 1, is characterized in that: described component A comprises the component of following percentage by weight:
3. medical pure bicarbonate dialysis dry powder according to claim 2, is characterized in that: described component A comprises the component of following percentage by weight:
4. the medical pure bicarbonate dialysis dry powder according to any one of claims 1 to 3, is characterized in that: described B component is made up of sodium bicarbonate, the quality of described sodium bicarbonate: quality=0.1 ~ 1 of sodium chloride in component A.
5. medical pure bicarbonate dialysis dry powder according to claim 4, is characterized in that: the quality of described sodium bicarbonate: quality=0.1 ~ 0.5 of sodium chloride in component A.
6. medical pure bicarbonate dialysis dry powder according to claim 4, is characterized in that: the quality of described sodium bicarbonate: quality=0.4 of sodium chloride in component A.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510904019.3A CN105434460A (en) | 2015-12-09 | 2015-12-09 | Medical pure sodium bicarbonate dialysis dry powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510904019.3A CN105434460A (en) | 2015-12-09 | 2015-12-09 | Medical pure sodium bicarbonate dialysis dry powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105434460A true CN105434460A (en) | 2016-03-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510904019.3A Pending CN105434460A (en) | 2015-12-09 | 2015-12-09 | Medical pure sodium bicarbonate dialysis dry powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105434460A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823217A (en) * | 2017-11-24 | 2018-03-23 | 安徽金阳光农业服务有限公司 | Compound NaCl dissipate and preparation method thereof |
| CN113368129A (en) * | 2021-06-28 | 2021-09-10 | 广州骐骥生物科技有限公司 | Sugar-free bicarbonate hemodialysis concentrated solution and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1448145A (en) * | 2003-04-30 | 2003-10-15 | 广州康盛生物科技有限公司 | Bicarbonate dry powder composition for hemodialysis |
| WO2015050188A1 (en) * | 2013-10-02 | 2015-04-09 | 富田製薬株式会社 | Solid dialysis a agent containing alkali metal diacetate, and two-part type low-acetate dialysis agent using same |
-
2015
- 2015-12-09 CN CN201510904019.3A patent/CN105434460A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1448145A (en) * | 2003-04-30 | 2003-10-15 | 广州康盛生物科技有限公司 | Bicarbonate dry powder composition for hemodialysis |
| WO2015050188A1 (en) * | 2013-10-02 | 2015-04-09 | 富田製薬株式会社 | Solid dialysis a agent containing alkali metal diacetate, and two-part type low-acetate dialysis agent using same |
Non-Patent Citations (1)
| Title |
|---|
| 陈香美，等: "《现代慢性肾衰治疗学》", 31 May 2001, 人民军医出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823217A (en) * | 2017-11-24 | 2018-03-23 | 安徽金阳光农业服务有限公司 | Compound NaCl dissipate and preparation method thereof |
| CN113368129A (en) * | 2021-06-28 | 2021-09-10 | 广州骐骥生物科技有限公司 | Sugar-free bicarbonate hemodialysis concentrated solution and preparation method thereof |
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| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160330 |