CN101002795A - Method for preparing dialysis dry powder and dialysate of pure sodium bicarbonate - Google Patents
Method for preparing dialysis dry powder and dialysate of pure sodium bicarbonate Download PDFInfo
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- CN101002795A CN101002795A CN 200610006577 CN200610006577A CN101002795A CN 101002795 A CN101002795 A CN 101002795A CN 200610006577 CN200610006577 CN 200610006577 CN 200610006577 A CN200610006577 A CN 200610006577A CN 101002795 A CN101002795 A CN 101002795A
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Abstract
A dried powder or liquid of medical high-purity sodium dicarbonate for dialysis with portable artificial kidney (blood dialysis machine) MR-100 to treat renal failure, uremia, poisoning and gout is prepared from sodium chloride and high-purity sodium dicarbonate. Its preparing process is also disclosed.
Description
The compound method of medical pure bicarbonate dialysis dry powder and dialysis solution the present invention relates to dialysis dry powder, the especially compound method of medical pure bicarbonate dialysis dry powder and dialysis solution of a kind of blood purification treatment with the preparation dialysis solution.The present invention is suitable for the clinical use treatment of portable artificial kidney (MR-100 type removable haemodialysis control unit) acute renal failure, chronic renal failure, uremia, poisonous substance, drug intoxication, heroin poisoning, addiction, severe pancreatitis etc.Also be fit to various lasting kidney alternative medicines (C R R T) and be used for continuous arterio venous hemofiltration dialysis (CAVHD), continuous vein-vein hemofiltration dialysis (CVVHD) etc. is used for various emergency treatments.
" dialysis dry powder " and " bicarbonate dialysate " all using in the conventional hemodialysis (CHD) work of all import conventional hemodialysis (CHD) machines in the background technology, but all be the dialysis dry powder that is added with sodium acetate or glacial acetic acid composition, because sodium acetate or glacial acetic acid are not the Human Physiology materials, patient's normal acetate that takes place in therapeutic process does not tolerate phenomenon, bad phenomenon such as nervous, uncomfortable in chest, hypotension, shock appear, in therapeutic process, produce emergency situation, in case it is untimely to rescue processing, may jeopardize patient's life security.Acetic acid itself can stimulate body to discharge multiple inflammatory cytokine, as interleukin I (IL-I), tumor necrosis factor (TNF), prostaglandin 2 (PGF2) etc., these factors be released in the important function that plays pathology physiology aspect in many complication, and be one of reason that produces chronic hyperphospheremia.
The concentration of acetate that the conventional hemodialysis (CHD) machine is used and the various compositions of bicarbonate dialysis liquid system such as following table:
| The sodium acetate dialysis solution | Bicarbonate dialysate | |
| Sodium [Na+] mmol/L potassium [K+] mmol/L calcium [Ca2+] mmol/L magnesium [Mg2+] mmol/L chlorine [Cl-] mmol/L acetate [CH3COO-] mmol/L bicarbonate [HCO3-] mmol/L glucose [C6H12O6] mmol/L pH osmotic pressure/mOsm/ (H2O.Kg) | 132～145 0～3 1.5～2.0 0.75 99～110 31～45 - 0～5.5 6～7 280～300 | 137～144 0～3 1.25～2.0 0.25～0.75 98～112 2.5～10 27～35 0～5.5 7.1～7.3 285～295 |
Annotate: this table is selected from Wang Zhigang chief editor blood purification and is learned the 2nd edition the 77th page, Beijing science tech publishing house.
No acetate dialyzate compound method commonly used has: (1) high CO2 dialysis solution of opening: need the lasting input of an airtight dialysis solution system and CO2 during use, and CO2 dividing potential drop monitoring technology, the clinical development acquires a certain degree of difficulty, and to the patient of respiratory function difference, the danger that causes that CO2 poisons arranged.(2) high chlorine dialysis solution: the dialysis beginning is with the chloride ion of high concentration, Cl-110～145mmol/l, HCO3-and CO2 concentration are normal, be that intracellular phosphonium ion is able to more removing, heighten again subsequently that HCO3-concentration reaches 35～40mmol/l in the dialysis solution, make whole dialysis procedure obtain enough bases, well correct acidosis.4 hermetically sealed containers of technical needs carry out simultaneously with two kinds of concentrated solutions of variable concentrations gradient respectively.(3) glycylglycine: with the stabilizing agent of glycylglycine as the carbonic acid dialysis solution; can obviously stop calcium, magnesium precipitate, make pH stable, and glycine be the aminoacid that the patient of uremia lacks; help protecting cell and residual renal function, costing an arm and a leg to be extensive use of it.(4) L-type lactic acid dialysis solution: different with D-type lactic acid peritoneal dialysis liquid is, because it has good buffering function that peritoneum is stimulated advantages such as little, reduces the Fibrotic advantage of peritoneum, has been applied to peritoneal dialysis solution at present, in the application of blood dialysis solution also still in experimental stage.(5) compound aminoacid: the domestic scholar of having utilizes several amino acids to turn down the pH value of carbonic acid dialysis solution, also can stop calcium, magnesium precipitate.Yet these no acetic acid dialysis process or implementation procedure are too complicated, or trace utilization cost is too high, is unfavorable for applying.
Purpose of the present invention is exactly the deficiency of meter to existing hydrocarbonate dialysis dry powder, a kind of medical pure bicarbonate dialysis dry powder of design and the compound method of dialysis solution, realize no acetate dialysis, thoroughly eliminate the harmful effect that the acetate dialysis solution produces the patient in hemodialysis.
The present invention is achieved in that the compound method of medical pure bicarbonate dialysis dry powder and pure sodium bicarbonate dialysis solution, it is characterized in that: the raw material of pure sodium bicarbonate dialysis dry powder uses venous transfusion medicine material composition, by sodium bicarbonate (
BIcarbonate, B) 27g (1) constitutes the B powder, adopts the medical package material to be packaged into one bag or one box; By sodium chloride (
cHloride, natruium, Nacl) 63g (2), potassium chloride (
cHloride potassium, Kcl) 3g (3), calcium chloride (
cHloride cacilium, Cacl) 4g (4), magnesium chloride (
cHloridemeganium, Mgcl) 2g (5), (Glucose, GS) 15g (6) constitutes the A powder to glucose, adopts the medical package material to be packaged into one bag or one box.The compound method of pure sodium bicarbonate dialysis solution is: add reverse osmosis water or aquae destillata 10000ml earlier in liquid dispensing device (container), then the A powder, that is: raw material composition (2), (3), (4), (5), (6) join in the liquid dispensing device (container), unlatching heat the weighing apparatus warm power supply, hemodialysis was used preceding 6～10 minutes, stirred gently in liquid dispensing device with cleaning macromolecular material rod the A powder is dissolved fully; Dialysis was used preceding about 3～5 minutes, the B powder is joined in the liquid dispensing device, stir gently with the macromolecular material rod, the B powder is dissolved fully, time to be used was near preceding about 3 minutes, can be encased in the pure sodium bicarbonate dialysis solution of being prepared in the dialysis fluid container (dialysis solution bucket), be used for hemodialysis; The dialysis solution that the present invention prepared, various compositions and ion concentration see the following form:
| Each ion concentration of pure bicarbonate dialysis liquid system | The pure sodium bicarbonate dialysis solution |
| Sodium [Na+] mmol/L potassium [K+] mmol/L calcium [Ca2+] mmol/L magnesium [Mg2+] mmol/L chlorine [Cl-] mmol/L bicarbonate [HCO3-] mmol/L glucose [C6H12O6] mmol/L pH osmotic pressure/mOsm/ (H2O.Kg) | 139.9 0～4.2 (according to the state of an illness no potassium or low potassium liquid) 2.67 1.25 112.2 28～33.0 8～9.11 7.35～7.4 295 |
The present invention can also be achieved in that its feature also is: the raw material composition of pure sodium bicarbonate dialysis dry powder by sodium bicarbonate (
BIcarbonate, B) 27g (1) constitutes B powder X2 bag or two boxes; By sodium chloride (
cHloride, natruium, Nacl) 63g (2), potassium chloride (
cHloride potassium, Kcl) 3g (3), calcium chloride (
cHloridecacilium, Cacl) 4g (4), magnesium chloride (
cHloride meganium, Mgcl) 2g (5), (Glucose, GS) 15g (6) constitutes A powder, X2 bag or two boxes to glucose.In the container of liquid dispensing device, add dialysis reverse osmosis water or aquae destillata 20000ml earlier, 2 bags or two box A powder are joined in the liquid dispensing device (container), unlatching heat the weighing apparatus warm power supply, 6～10 minutes before use, after stirring is dissolved the A powder fully gently in liquid dispensing device with cleaning macromolecular material rod, dialysis is used and 2 bags in B powder or two boxes to be joined in the liquid dispensing device in preceding about 3～5 minutes, after stirring is treated to dissolve fully gently, can use;
The present invention can also be achieved in that its feature also is: (Bicarbonate, B) 27g (1) constitutes one bag of X of B powder to the raw material composition of medical pure bicarbonate dialysis dry powder by sodium bicarbonate
nBag or 27gX
nBox; By sodium chloride (
cHloride, natruium, Nacl) 63g (2), potassium chloride (
cHloride potassium, Kcl) 3g (3), calcium chloride (
cHloride cacilium, Cacl) 4g (4), magnesium chloride (
cHloride meganium, Mgcl) 2g (5), (Glucose, GS) 15g (6) constitutes the A powder to glucose, is packaged into one bag of X
nThe bag or by sodium chloride (
cHloride, natruium, Nacl) 63g (2), potassium chloride (
cHloride potassium, Kcl) 3g (3), calcium chloride (
cHloridecacilium, Cacl) 4g (4), magnesium chloride (
cHloride meganium, Mgcl) 2g (5), glucose (Glucose, GS) 15g (6) X
nBox, the preparation program when preparation is used in batch;
The present invention can also be achieved in that its feature also is: (Bicarbonate, B) 27g (1) constitutes one bag of X of B powder to the raw material composition of medical pure bicarbonate dialysis dry powder by sodium bicarbonate
nBag or 27gX
nBy sodium chloride (
cHloride, natruium, Nacl) 63g (2), potassium chloride (
cHloride potassium, Kcl) 0～2g (3), calcium chloride (
cHloride cacilium, Cacl) 4g (4), magnesium chloride (
cHloride meganium, Mgcl) 2g (5), glucose (Glucose, GS) 15g (6) constitutes the A powder, be packaged into 11 bags or by sodium chloride (
cHloride, natruium, Nacl) 63g (2), potassium chloride (
cHloride potassium, Kcl) 0～2g (3), calcium chloride (
cHloride cacilium, Cacl) 4g (4), magnesium chloride (
cHloride meganium, Mgcl) 2g (5), glucose (Glucose, GS) 15g (6) X
n, when preparation is used in batch at hyperkalemia patient's special-purpose preparation program.
The present invention's good effect compared with prior art is: 1, thoroughly taken down acetate, eliminated the acetate dialysis harmful effect all to human body; 2, the used raw material of pure sodium bicarbonate dialysis dry powder is the raw material that intravenous transfusion is used entirely, and quality is very reliable; The dialysis dry powder amount of 3, once dialysing used is than traditional haemodialysis control unit consumption conservation 53.85～100%, and is as shown in the table:
Tradition concentrates A, B liquid dry powder and pure sodium bicarbonate dry powder and once dialyses amount ratio:
| The dialysis dry powder composition | Tradition hemo system dialysis dry powder composition consumption and pure sodium bicarbonate dry powder amount ratio are | |
| Tradition concentrated solution dry powder | The pure sodium bicarbonate dialysis dry powder | |
| Each composition of A liquid: | Each composition of A liquid (g) | Each composition of A liquid (g) conservation (%) |
| 1, sodium chloride (Nacl) | 1053.5 | 63×4＝252 76.08 |
| 2, potassium chloride (Kcl) | 26.0 | 3×4＝12 53.85 |
| 3, calcium chloride (Cacl (H2O) 2 | 38.5 | 4×4＝16 58.44 |
| 4, magnesium chloride Mg cl (H2O) 6 | 26.5 | 2×4＝8 69.81 |
| 5, glucose (H2O) | 192.5 | 15×4＝60 68.83 |
| 6, glacial acetic acid | 37.0 | --------- 100.00 |
| 7, Jia Shui (RO water) | 5000ml | 40000ml |
| B liquid composition | Tradition concentrates B liquid powder | B liquid composition (g/40000ml) |
| 1、NaHCO3 | 525 | 27×4＝108 79.42 |
| 2, Jia Shui (RO) | 6250ml | ---------- |
Above-mentioned dosing is fit to dialysis in 5 hours and uses.
Embodiment: use accurate electronic scale, take by weighing sodium bicarbonate 27 grams respectively, standby as dialysis B powder; Adopt medical material and be packaged into one bag or one box; Take by weighing sodium chloride 63 grams again, potassium chloride 3 grams, calcium chloride 4 grams, magnesium chloride 2 grams, glucose 15 grams have been adopted the medical package material and have been packaged into one bag or one box, and are standby as dialysis A powder.Put into 10000ml reverse osmosis water or aquae destillata in liquid dispensing device (container), open the warm power supply of weighing apparatus of heating, design temperature is to the physiological temp (37.5～38.5 ℃) of human body.Hemodialysis was used preceding 6～10 minutes, stirred gently in liquid dispensing device with cleaning macromolecular material rod the A powder is dissolved fully; Dialysis was used preceding about 3～5 minutes, the B powder is joined in the liquid dispensing device, stir gently with the macromolecular material rod, the B powder is dissolved fully, time to be used was near preceding about 3 minutes, can be encased in the pure sodium bicarbonate dialysis solution of preparation in the dialysis fluid container (dialysis solution bucket), be used for hemodialysis.
Claims (4)
1, the compound method of medical pure bicarbonate dialysis dry powder and pure sodium bicarbonate dialysis solution is characterized in that: the raw material of pure sodium bicarbonate dialysis dry powder uses venous transfusion medicine material composition, by sodium bicarbonate (
BIcarbonate, B) 27g (1) constitutes the B powder, adopts the medical package material to be packaged into one bag or one box; By sodium chloride (
cHloride, natruium, Nacl) 63g (2), potassium chloride (
cHloride potassium, Kcl) 0～3g (3), calcium chloride (
cHloride cacilium, Cacl) 4g (4), magnesium chloride (
cHloride meganium, Mgcl) 2g (5), (Glucose, GS) 15g (6) constitutes the A powder to glucose, adopts the medical package material to be packaged into one bag or one box.The compound method of pure sodium bicarbonate dialysis solution is: add reverse osmosis water or aquae destillata 10000ml earlier in liquid dispensing device (container), then A liquid powder, that is: raw material composition (2), (3), (4), (5), (6) join in the liquid dispensing device (container), unlatching heat the weighing apparatus warm power supply, design temperature is in Human Physiology temperature scope (37.5～38.5 ℃), 36.0～37 ℃ of dialysis solution actual temperatures.Hemodialysis was used preceding 6～10 minutes, stirred gently in liquid dispensing device with cleaning macromolecular material rod the A powder is dissolved fully; Dialysis was used preceding about 3～5 minutes, the B powder is joined in the liquid dispensing device, stir gently with the macromolecular material rod, the B powder is dissolved fully, time to be used was near preceding about 3 minutes, can be encased in the pure sodium bicarbonate dialysis solution of preparation in the dialysis fluid container (dialysis solution bucket), be used for hemodialysis;
2, according to the compound method of the described medical pure bicarbonate dialysis of claim 1 dry powder, its feature also is: the raw material composition of pure sodium bicarbonate dialysis dry powder by sodium bicarbonate (
BIcarbonate, B) 27g (1) constitutes B powder X2 bag or two boxes; By sodium chloride (
cHloride, natruium, Nacl) 63g (2), potassium chloride (
cHloridepotassium, Kcl) 2.5～3g (3), calcium chloride (
cHloride cacilium, Cacl) 4g (4), magnesium chloride (
cHloridemeganium, Mgcl) 2g (5), (Glucose, GS) 15g (6) constitutes A powder, X2 bag or two boxes to glucose.In the container of liquid dispensing device, add dialysis reverse osmosis water or aquae destillata 20000ml earlier, 2 bags or two box A powder are joined in the liquid dispensing device (container), unlatching heat the weighing apparatus warm power supply, 6～10 minutes before use, stir gently in liquid dispensing device with cleaning macromolecular material rod the A powder is dissolved fully, dialysis is used and 2 bags in B powder or two boxes to be joined in the liquid dispensing device in preceding about 3～5 minutes, after the stirring and dissolving, can use gently;
3, according to the compound method of the described medical pure bicarbonate dialysis of claim 1 dry powder, its feature also is: (Bicarbonate, B) 27g (1) constitutes one bag of X of B powder to the raw material composition of medical pure bicarbonate dialysis dry powder by sodium bicarbonate
nBag or 27gX
nBox; By sodium chloride (
cHloride, natruium, Nacl) 63g (2), potassium chloride (
cHloride potassium, Kcl) 3g (3), calcium chloride (
cHloride cacilium, Cacl) 4g (4), magnesium chloride (
cHloride meganium, Mgcl) 2g (5), (Glucose, GS) 15g (6) constitutes the A powder to glucose, is packaged into one bag of X
nThe bag or by sodium chloride (
cHloride, natruium, Nacl) 63g (2), potassium chloride (
cHloride potassium, Kcl) 2.5～3g (3), calcium chloride (
cHloride cacilium, Cacl) 4g (4), magnesium chloride (
cHloridemeganium, Mgcl) 2g (5), (Glucose, GS) 15g (6) is packaged into one bag of formation A powder X to glucose
nBag or box, the preparation program when preparation is used in batch;
4, according to the compound method of the described medical pure bicarbonate dialysis of claim 1 dry powder, its feature also is: (Bicarbonate, B) 27g (1) constitutes one bag in B powder or one box X to the raw material composition of medical pure bicarbonate dialysis dry powder by sodium bicarbonate
nBag or 27gX
nBag or box; By sodium chloride (
cHloride, natruium, Nacl) 63g (2), potassium chloride (
cHloride potassium, Kcl) 0～2g (3), calcium chloride (
cHloride cacilium, Cacl) 4g (4), magnesium chloride (
cHloride meganium, Mgcl) 2g (5), (Glucose, GS) 15g (6) constitutes the A powder to glucose, is packaged into 11 bags/box X
nBag or box, when preparation is used in batch at hyperkalemia patient's special-purpose preparation program.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610006577 CN101002795A (en) | 2006-01-17 | 2006-01-17 | Method for preparing dialysis dry powder and dialysate of pure sodium bicarbonate |
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|---|---|---|---|
| CN 200610006577 CN101002795A (en) | 2006-01-17 | 2006-01-17 | Method for preparing dialysis dry powder and dialysate of pure sodium bicarbonate |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145010A (en) * | 2010-12-21 | 2011-08-10 | 李超群 | Use of combination of potassium and magnesium for preparing medicine for preventing or treating gout |
| CN104586884A (en) * | 2015-01-09 | 2015-05-06 | 李淑秀 | Novel hemodialysis concentrate |
-
2006
- 2006-01-17 CN CN 200610006577 patent/CN101002795A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102145010A (en) * | 2010-12-21 | 2011-08-10 | 李超群 | Use of combination of potassium and magnesium for preparing medicine for preventing or treating gout |
| CN104586884A (en) * | 2015-01-09 | 2015-05-06 | 李淑秀 | Novel hemodialysis concentrate |
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