CN111265732A - Continuous preparation equipment of peritoneal dialysis solution and replacement solution for continuous kidney replacement therapy - Google Patents

Continuous preparation equipment of peritoneal dialysis solution and replacement solution for continuous kidney replacement therapy Download PDF

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Publication number
CN111265732A
CN111265732A CN202010163437.2A CN202010163437A CN111265732A CN 111265732 A CN111265732 A CN 111265732A CN 202010163437 A CN202010163437 A CN 202010163437A CN 111265732 A CN111265732 A CN 111265732A
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liquid
module
solution
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郁赛杰
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郁赛杰
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A61M1/287—Dialysates therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00—Methods of manufacture, assembly or production
    • A61M2207/10—Device therefor

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  • Urology & Nephrology (AREA)
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Abstract

The embodiment of the invention discloses continuous preparation equipment for replacement liquid for peritoneal dialysis and continuous renal replacement therapy, which adopts the technical scheme that the equipment comprises a liquid inlet heating and degassing module, a continuous dilution proportioning module, an ultrapure filtering module and a liquid supply module, wherein the liquid inlet heating and degassing module, the continuous dilution proportioning module, the ultrapure filtering module and the liquid supply module are sequentially connected, the liquid inlet end of the liquid inlet heating and degassing module is connected with R0 pure water supply equipment, the liquid outlet end of the liquid supply module is connected with a liquid storage bag and is directly connected with peritoneal dialysis therapy equipment or continuous renal replacement therapy equipment, the liquid inlet heating and degassing module is used for heating and degassing R0 pure water, the continuous dilution proportioning module is used for adding A liquid, B liquid and C liquid into R0 pure water, the ultrapure filtering module is used for filtering and discharging impurities, the liquid supply module is used for pumping liquid medicine into the therapy equipment, and the purpose that bicarbonate replacement liquid or bicarbonate replacement liquid can be provided for the continuous renal replacement therapy equipment or the peritoneal dialysis therapy equipment Effect of saline dialysate.

Description

Continuous preparation equipment of peritoneal dialysis solution and replacement solution for continuous kidney replacement therapy
Technical Field
The embodiment of the invention relates to the technical field of medical equipment, in particular to continuous preparation equipment for peritoneal dialysis solution and replacement solution for continuous kidney replacement therapy.
Background
1. Current replacement fluid for Continuous Renal Replacement Therapy (CRRT):
continuous Renal Replacement Therapy (CRRT), also known as Continuous Blood Purification (CBP), is a new method of blood purification that has been developed. The first international conference on continuous renal replacement therapy in 1995 states that a continuous blood purification therapy for 24 hours or nearly 24 hours per day is used to replace the impaired renal function in a purification mode, i.e. continuous renal replacement therapy. Continuous renal replacement therapy includes continuous arteriovenous, venous hemofiltration (CAVH, CVVH), continuous arteriovenous, venous hemodialysis (CAVDH, CVVDH), continuous arteriovenous, venous hemodiafiltration (CAVHDF, CVVHDF) and like modalities.
CRRT treatment requires the use of large volumes of replacement fluid due to the 24 hour continuous run. The replacement liquid used at present is mainly a bagged lactic acid type replacement liquid produced in factories, and the transportation and storage costs are high. And when the lactate replacement fluid is used for lactic acidosis and the function of metabolic lactic acid of the organism is reduced (such as liver failure), the probability of high lactic acidemia is increased by using the lactate replacement fluid, and the death rate of patients is increased.
2. Current state of the art dialysate for peritoneal dialysis:
the peritoneal dialysis is based on the principle that the peritoneal membrane is used as a dialysis membrane to separate dialysate filled into the peritoneal cavity from blood, the peritoneal membrane has the property of a semipermeable membrane and has the characteristics of large area, abundant capillaries and the like, and the blood and the dialysate in the capillary vessel cavity of the peritoneal membrane soaked in the dialysate are subjected to wide material exchange so as to achieve the purposes of removing in-vivo metabolites and toxic substances and correcting imbalance of water electrolytes and acid-base balance. In abdominal dialysis, the solute exchange is mainly by diffusion and convection, and the removal of water is mainly by ultrafiltration by increasing osmotic pressure.
At present, the peritoneal dialysis solution is mainly bagged lactic acid type dialysis solution produced in factories, and the transportation and storage cost is high. And the lactate dialysate must be converted into bicarbonate through the metabolism of the liver to correct acidosis. Therefore, the use of some patients with liver diseases is limited. In addition, lactate can inhibit the function of immune system in abdominal cavity, and cause cardiovascular system complications such as hypotension, cardiovascular system dysfunction and myocardial contractility decrease.
The bicarbonate replacement fluid for CRRT treatment is most suitable for the physiological state of the body and is the most ideal replacement fluid. However, since Ca2+ (divalent calcium ion) and Mg2+ (divalent magnesium ion) in the bicarbonate replacement solution are likely to be crystallized, it is impossible to prepare and store HCO on a large scale3 -Bicarbonate ion is the leading ion in the human bodyThe buffer of (a), but is easily decomposed and can only be prepared temporarily.
The pH value of the bicarbonate dialysate for peritoneal dialysis is very close to the physiological condition of a human body, the irritation to the peritoneal membrane of the human body is very small, the discomfort such as abdominal pain is very little caused, and the bicarbonate dialysate is very suitable for patients who carry out peritoneal dialysis treatment for a long time. In addition, bicarbonate can produce therapeutic effects directly in vivo and rarely induce some systemic adverse effects, such as: hypotension, unstable cardiovascular system, weakened myocardial contraction, abnormal lipid metabolism, etc. This type of dialysate is considered to be the peritoneal dialysate that best conforms to the physiology of the human body. However, since Ca2+ (divalent calcium ion) and Mg2+ (divalent magnesium ion) in bicarbonate dialysate are easily crystallized, large-scale production preparation and storage cannot be performed3 -Bicarbonate ions are the most prominent buffering agent in the human body, but are easily decomposed and can only be prepared temporarily.
In summary, the dialysis fluid is limited by conditions and cannot satisfy all use requirements of the replacement fluid for Continuous Renal Replacement Therapy (CRRT) and the dialysis fluid for peritoneal dialysis, and only a lactate replacement fluid and a bagged lactic acid-based dialysis fluid with slightly poor effects can be used, which is not good for the health of patients.
Disclosure of Invention
Therefore, the embodiment of the invention provides peritoneal dialysis solution and continuous preparation equipment of replacement solution for continuous kidney replacement therapy, which aims to solve the problem that the dialysis solution in the prior art is limited by conditions and cannot meet all use requirements of the replacement solution for continuous kidney replacement therapy (CRRT) and the dialysis solution for peritoneal dialysis.
In order to achieve the above object, the embodiments of the present invention provide the following technical solutions:
a continuous preparation device of replacement liquid for peritoneal dialysis solution and continuous kidney replacement therapy comprises a liquid inlet heating degassing module, a continuous dilution proportioning module, an ultra-pure filtration module and a liquid supply module, the liquid feeding heating degassing module, the continuous dilution proportioning module, the ultra-pure filtering module and the liquid feeding module are connected in sequence, the liquid inlet end of the liquid inlet heating degassing module is connected with an R0 pure water supply device, the liquid outlet end of the liquid supply module is connected with a continuous kidney replacement therapy device, the liquid inlet heating degassing module is used for heating and degassing R0 pure water, the continuous dilution proportioning module is used for adding liquid A, liquid B and liquid C into R0 pure water, the ultra-pure filtration module is used for filtering bacteria and endotoxin and discharging impurities, and the liquid supply module is used for pumping liquid medicine into an aseptic liquid storage bag, continuous kidney replacement treatment equipment or peritoneal dialysis treatment equipment.
Further, the liquid inlet heating degassing module comprises a pressure reducing valve PRV, a water inlet valve V4, a water inlet pressure detection sensor PT1, a heater HR, a temperature control sensor T1/2/3 and a degassing pump P4 which are sequentially connected, wherein an inlet of the pressure reducing valve PRV is connected with R0 pure water supply equipment, an outlet of the degassing pump P4 is connected with a continuous dilution proportioning module, and the heater HR is provided with an overtemperature protector THS.
Further, the continuous dilution proportioning module comprises a first mixing cavity MC1, a first conductivity sensor CL1, a second mixing cavity MC2, a second conductivity sensor CL2, a third mixing cavity MC3 and an osmotic pressure sensor OP1 which are sequentially connected, a liquid B suction pipeline, a liquid A suction pipeline and a liquid C suction pipeline, wherein the liquid inlet end of the first mixing cavity MC1 is connected with the liquid outlet end of the liquid inlet heating and degassing module through a pipeline, the liquid outlet end of the liquid B suction pipeline is connected to the liquid inlet end of the first mixing cavity MC1, the liquid outlet end of the liquid A suction pipeline is connected to the liquid inlet end of the second mixing cavity MC2, the liquid outlet end of the liquid C suction pipeline is connected to the liquid inlet end of the third mixing cavity MC3, a liquid pump P1 is arranged on the liquid B suction pipeline, an A liquid pump P2 is arranged on the liquid A suction pipeline, and a C liquid pump P3 is arranged on the liquid C suction pipeline.
Furthermore, the inlet of the liquid B suction pipeline is connected with the outlet of the liquid B medicine barrel, the inlet of the liquid A suction pipeline is connected with the outlet of the liquid A medicine barrel, and the inlet of the liquid C suction pipeline is connected with the outlet of the liquid C medicine barrel.
Further, B liquid inhales pipeline access connection B dry powder bucket export, A liquid inhales pipeline access connection A dry powder bucket export, and C liquid inhales pipeline access connection C dry powder bucket export, and B liquid dry powder bucket entry, A liquid dry powder bucket entry and C liquid dry powder bucket entry are connected the feed liquor respectively and are heated the play liquid end of degasification module.
Further, the ultrapure filtering module comprises a first filter CF1, a second filter CF2 and a detection auxiliary unit, wherein an inlet of the first filter CF1 is connected with a liquid outlet end of the serial dilution proportioning module, an outlet of the first filter CF1 is connected with an inlet of the second filter CF2, an outlet of the second filter CF2 is connected with a liquid inlet end of the liquid supply module, the detection auxiliary unit is respectively connected with waste liquid outlets of the first filter CF1 and the second filter CF2, impurities filtered by the first filter CF1 and the second filter CF2 are discharged into a waste liquid discharge pipeline, and the detection auxiliary unit is used for detecting the integrity of filter membranes of the first filter CF1 and the second filter CF 2.
Further, the detection auxiliary unit comprises an air filter FL4, a solenoid valve V11 and a check valve OW1 which are connected in sequence, wherein the inlet of the check valve OW1 is connected with the outlet of the solenoid valve V11, and the outlet of the check valve OW1 is respectively connected with the waste liquid outlets of the first filter CF1 and the second filter CF 2.
Further, the liquid supply module comprises a pressure detector PT2, a flow pump P5, a temperature sensor T2/3, a turbine flowmeter F1 and an external unit which are connected in sequence, an inlet of the pressure detector PT2 is connected with a liquid outlet end of the ultra-pure filtration module, a back pressure valve H2 is connected in parallel to the flow pump P5, the external unit comprises a bypass valve V9, a first liquid supply valve V7, a second liquid supply valve V8 and a liquid supply interface IF1, an inlet of the bypass valve V9 is connected with an outlet of the turbine flowmeter F1, an outlet of the bypass valve V9 is connected with a waste liquid discharge pipeline, an inlet of the first liquid supply valve V63 7 is connected with an inlet of the bypass valve V635928, an outlet of the first liquid supply valve V7 is connected with the liquid supply interface IF1, an inlet of the second liquid supply valve V8 is connected with the liquid supply interface IF1, an outlet of the second liquid supply valve V8 is connected with an outlet of the liquid supply valve V9, an interface IF 36 1 is provided with an interface sensor S3687458, and, A continuous renal replacement therapy device or a peritoneal dialysis therapy device.
Furthermore, peritoneal dialysis liquid, continuous kidney substitution treatment are with replacement liquid continuous preparation equipment still include the antiseptic solution and inhale the module, the antiseptic solution inhales the module and sets up on waste liquid discharge pipeline for carry out disinfection treatment to the whole water route of equipment and part waste liquid.
Further, antiseptic solution inhales module includes disinfection solenoid valve V10 and disinfectant bucket, the liquid outlet of disinfectant bucket passes through disinfection solenoid valve V10 and connects the waste liquid discharge pipeline.
The embodiment of the invention has the following advantages:
the peritoneal dialysis solution and the continuous preparation equipment for the replacement solution for continuous kidney replacement therapy can suck the bicarbonate replacement solution or the bicarbonate dialysis solution for the continuous kidney replacement therapy equipment or the peritoneal dialysis therapy equipment in real time, so that adverse reactions of patients caused by the use of the lactate replacement solution and the bagged lactic acid type dialysis solution can be avoided, and the problem of medicament decomposition does not need to be considered.
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In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It is obvious that the drawings in the following description are merely exemplary, and that for a person skilled in the art, other implementation drawings can be derived from the supplied drawings without inventive effort.
The structures, ratios, sizes, and the like shown in the present specification are only used for matching with the contents disclosed in the specification, so that those skilled in the art can understand and read the present invention, and do not limit the conditions for implementing the present invention, so that the present invention has no technical significance, and any structural modifications, changes in the ratio relationship, or adjustments of the sizes, without affecting the functions and purposes of the present invention, should still fall within the scope of the present invention.
FIG. 1 is a schematic diagram illustrating a connection relationship between a peritoneal dialysis solution and a replacement solution continuous preparation apparatus for continuous renal replacement therapy according to an embodiment of the present invention;
FIG. 2 is a piping diagram of a peritoneal dialysis solution, replacement solution continuous preparation apparatus for continuous renal replacement therapy provided by an embodiment of the present invention;
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The utility model provides a peritoneal dialysis liquid, continuous kidney substitution treatment is with replacement liquid continuous preparation equipment, combines fig. 1 and fig. 2, including feed liquor heating degassing module 1, dilution ratio module 2 in succession, ultrapure filtration module 3 and confession liquid module 4, feed liquor heating degassing module 1, dilution ratio module 2 in succession, ultrapure filtration module 3 and confession liquid module 4 connect gradually, the feed liquor end of feed liquor heating degassing module 1 connects R0 pure water supply equipment, the play liquid end of confession liquid module 4 connects continuous kidney substitution treatment equipment.
The liquid inlet heating degassing module 1 is used for heating and degassing R0 pure water to make the temperature of R0 pure water suitable for human body, and removing gas dissolved in the R0 pure water, the continuous dilution proportioning module 2 is used for adding the A liquid, the B liquid and the C liquid into the R0 pure water according to the required dilution ratio to form peritoneal dialysis solution or replacement solution for continuous kidney replacement therapy, the liquid A is a strong acid concentrated liquid, the liquid B is a concentrated sodium bicarbonate strong alkali liquid, the liquid C is a glucose solution, the ultrapure filtering module 3 is used for filtering bacteria and endotoxin in the mixed liquid medicine and discharging impurities in the mixed liquid medicine to form peritoneal dialysis liquid which can be directly used for treatment and replacement liquid for continuous kidney replacement treatment, and the liquid supply module 4 is used for pumping the peritoneal dialysis liquid and the replacement liquid for continuous kidney replacement treatment into a sterile liquid storage bag, continuous kidney replacement treatment equipment or peritoneal dialysis treatment equipment for treatment.
The continuous preparation equipment for the peritoneal dialysis solution and the replacement solution for continuous kidney replacement therapy can supply bicarbonate replacement solution for CRRT therapy or bicarbonate peritoneal dialysis solution for peritoneal dialysis in real time, solves the problem that the bicarbonate replacement solution and the bicarbonate peritoneal dialysis solution are easy to decompose, and has better treatment effect on patients.
The liquid inlet heating degassing module 1 comprises a pressure reducing valve PRV, a water inlet valve V4, a water inlet pressure detection sensor PT1, a heater HR, a temperature control sensor T1 and a degassing pump P4 which are connected in sequence, an inlet of the pressure reducing valve PRV is connected with R0 pure water supply equipment, R0 pure water can be heated through the heater HR, so that the requirement of the human body using temperature is met, an overtemperature protector THS is arranged on the heater HR, the condition that the heater HR is damaged due to idle combustion is avoided, R0 pure water is discharged through the degassing pump P4 after entering the degassing pump P4, an outlet of the degassing pump P4 is connected with the continuous dilution proportioning module 2, and the R0 which is heated and degassed is pumped into the continuous dilution proportioning module 2.
Preferably, a back pressure valve H1 is connected in parallel to a connection pipe between the heater HR, the temperature control sensor T1 and the degassing pump P4, one end of the back pressure valve H1 is connected to an inlet of the water pressure detection sensor PT1, and the other end is connected to an outlet of the degassing pump P4, and the hydraulic pressure supplied to the proportioning module 2 can be conveniently adjusted by providing the back pressure valve H1.
The continuous dilution proportioning module 2 comprises a first mixing cavity MC1, a first conductivity sensor CL1, a second mixing cavity MC2, a second conductivity sensor CL2, a third mixing cavity MC3 and an osmotic pressure sensor OP1 which are sequentially connected, a liquid B suction pipeline, a liquid A suction pipeline and a liquid C suction pipeline, wherein a liquid inlet end of the first mixing cavity MC1 is connected with a liquid outlet end of the liquid inlet warming and degassing module 1 through a pipeline, a liquid outlet end of the liquid B suction pipeline is connected with a liquid inlet end of the first mixing cavity MC1, a liquid outlet end of the liquid A suction pipeline is connected with a liquid inlet end of the second mixing cavity MC2, a liquid outlet end of the liquid C suction pipeline is connected with a liquid inlet end of the third mixing cavity MC3, a liquid B pump P1 is arranged on the liquid B suction pipeline, an liquid A pump P2 is arranged on the liquid A suction pipeline, and a liquid C pump P3 is arranged on the liquid C suction pipeline.
The B liquid is pumped into the first mixing chamber MC1 by the B liquid suction pipeline, so that the B liquid and the RO pure water are mixed, and the first conductivity sensor CL1 can detect the mixing ratio of the B liquid and the RO pure water, so that the B liquid pump P1 can conveniently adjust the proportioning of the B liquid;
the liquid A is pumped into the second mixing cavity MC2 by the liquid A suction pipeline, so that the liquid A, the liquid B and RO pure water are mixed together, the second conductivity sensor CL2 can monitor the mixing proportion of the liquid A by detecting the conductivity of the mixed liquid, and the proportion of the liquid A is conveniently adjusted by the liquid A pump P2;
the C liquid is pumped into the third mixing cavity MC3 by the C liquid suction pipeline and is mixed with the liquid in the second mixing cavity MC2, and the osmotic pressure sensor OP1 can directly measure the C liquid mixing proportion, so that the C liquid ratio can be conveniently adjusted by the C liquid pump P3.
As an inhalation mode of the liquid A, the liquid B and the liquid C, the liquid A, the liquid B and the liquid C are all liquid, a liquid medicine barrel is adopted for containing, an inlet of a liquid B inhalation pipeline is connected with an outlet of the liquid medicine barrel of the liquid B, an inlet of the liquid A inhalation pipeline is connected with an outlet of the liquid medicine barrel of the liquid A, and an inlet of a liquid C inhalation pipeline is connected with an outlet of the liquid medicine barrel of the liquid C.
As another suction mode of the liquid A, the liquid B and the liquid C, the liquid A, the liquid B and the liquid C are dry powders, a dry powder barrel is adopted for storage, an inlet of a liquid B suction pipeline is connected with an outlet of the dry powder barrel B, an inlet of the liquid A suction pipeline is connected with an outlet of the dry powder barrel A, an inlet of a liquid C suction pipeline is connected with an outlet of the dry powder barrel C, and an inlet of the dry powder barrel B, an inlet of the dry powder barrel A and an inlet of the dry powder barrel C are respectively connected with a liquid outlet end of the liquid inlet heating degassing module 1.
When liquid A, liquid B and liquid C are transported at a short distance, liquid A, liquid B and liquid C can be preferentially adopted, the production and use cost is low, when liquid A, liquid B and liquid C are transported at a long distance, dry powder A, dry powder B and dry powder C can be preferentially adopted, and the transportation and the storage are safer and more convenient.
The ultra-pure filtering module 3 comprises a first filter CF1, a second filter CF2 and a detection auxiliary unit, wherein an inlet of the first filter CF1 is connected with a liquid outlet end of the continuous dilution proportioning module 2, an outlet of the first filter CF1 is connected with an inlet of the second filter CF2, an outlet of the second filter CF2 is connected with a liquid inlet end of the liquid supply module 4, the detection auxiliary unit is connected with waste liquid outlets of the first filter CF1 and the second filter CF2, impurities filtered by the first filter CF1 and the second filter CF2 are discharged into a waste liquid discharge pipeline, and bacteria, endotoxin and impurities in the liquid medicine are effectively removed through double filtration of the first filter CF1 and the second filter CF2, so that the prepared liquid medicine is safer to use.
The detection auxiliary unit is used for detecting the integrity of the filter membranes of the first filter CF1 and the second filter CF2, and can avoid the situation that the liquid medicine is continuously delivered to the patient when the filter membranes of the first filter CF1 and the second filter CF2 are damaged.
The detection auxiliary unit comprises an air filter FL4, a solenoid valve V11 and a check valve OW1 which are connected in sequence, wherein the inlet of the check valve OW1 is connected with the outlet of the solenoid valve V11, and the outlet of the check valve OW1 is connected with the waste liquid discharge ports of the first filter CF1 and the second filter CF 2. By utilizing the principle that the first filter CF1 and the second filter CF2 cannot permeate air when the filter membranes are intact, whether the air introduced from the air filter FL4 can pass through the first filter CF1 and the second filter CF2 is detected, namely whether the filter membranes of the first filter CF1 and the second filter CF2 are intact can be detected, the use safety is ensured, and bacteria, endotoxin and impurities are prevented from entering the human body.
The liquid supply module 4 comprises a pressure detector PT2, a flow pump P5, a temperature sensor T2/3, a turbine flowmeter F1 and an external unit which are connected in sequence, an inlet of the pressure detector PT2 is connected with a liquid outlet end of the ultra-pure filtration module 3, a back pressure valve H2 is connected in parallel to the flow pump P5, the external unit comprises a bypass valve V9, a first liquid supply valve V7, a second liquid supply valve V8 and a liquid supply interface IF1, an inlet of the bypass valve V9 is connected with an outlet of the turbine flowmeter F1, an outlet of the bypass valve V9 is connected with a waste liquid discharge pipeline, an inlet of the first liquid supply valve V7 is connected with an inlet of the bypass valve V9, an outlet of the first liquid supply valve V7 is connected with a liquid supply interface IF1, an inlet of the second liquid supply valve V8 is connected with a liquid supply interface IF1, an outlet of the second liquid supply valve V8 is connected with an outlet of the bypass valve V9, a liquid supply interface IF 7 is arranged on the liquid supply interface IF1, and the liquid supply, the liquid supply module 4 can pump the liquid medicine into the sterile liquid storage bag and connect the continuous kidney replacement therapy equipment or the peritoneal dialysis therapy equipment for use after ensuring that the liquid medicine is adjusted to proper pressure, temperature and concentration.
The flow pump P5 can provide liquid supply power for pumping the liquid medicine into the sterile liquid storage bag, connecting the continuous kidney replacement therapy equipment or the peritoneal dialysis therapy equipment, and can also be used for assisting the detection of the detection auxiliary unit, wherein before the detection, the liquid medicine can be discharged through the flow pump P5, then negative pressure is continuously generated through the flow pump P5, the electromagnetic valve V11 is opened, other passages which can enter the first filter CF1 and the second filter CF2 are closed, whether air can pass through the filter membranes of the first filter CF1 and the second filter CF2 is detected, and whether the first filter CF1 and the second filter CF2 have broken membranes or not can be known.
Preferably, peritoneal dialysis solution, continuous kidney replacement treatment are with replacement liquid continuous preparation equipment still include antiseptic solution and inhale module 5, and antiseptic solution inhales module 5 and sets up on waste liquid discharge pipeline for carry out disinfection treatment to the whole water route of equipment and part, guarantee to be in sterile condition all the time in the pipeline.
The disinfectant suction module 5 comprises a disinfection electromagnetic valve V10 and a disinfectant barrel, and a liquid outlet of the disinfectant barrel is connected with a waste liquid discharge pipeline through a disinfection electromagnetic valve V10. After the disinfection electromagnetic valve V10 is opened, disinfectant in the disinfectant barrel can be sucked into the pipeline, mixed according to a set dilution ratio and thoroughly disinfected to the whole waterway and components of the equipment, so that the continuous preparation equipment for the peritoneal dialysis solution and the continuous kidney replacement treatment replacement solution is safer and more environment-friendly to use, and pollution is avoided.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims (10)

1. The utility model provides a peritoneal dialysis liquid, continuous kidney substitute replacement liquid continuous preparation equipment for treatment, a serial communication port, heat degasification module (1), dilute ratio module (2), ultrapure filtration module (3) and supply liquid module (4) in succession including the feed liquor, the feed liquor heats degasification module (1), dilutes ratio module (2), ultrapure filtration module (3) in succession and supplies liquid module (4) to connect gradually, the feed liquor end that the feed liquor warmed degasification module (1) connects R0 pure water supply equipment, the play liquid end that supplies liquid module (4) connects continuous kidney and replaces treatment equipment, the feed liquor heats module (1) and is used for heating and the degasification to R0 pure water, dilute ratio module (2) in succession is used for adding A liquid, B liquid and C liquid in to R0 pure water, ultrapure filtration module (3) is used for filtering bacterium and endotoxin, Impurities are discharged, and the liquid supply module (4) is used for pumping the liquid medicine into a sterile liquid storage bag, a continuous kidney replacement therapy device or a peritoneal dialysis therapy device.
2. The peritoneal dialysis solution, replacement fluid continuous preparation equipment for continuous kidney replacement therapy according to claim 1, characterized in that the feed liquid warming and degassing module (1) comprises a Pressure Reducing Valve (PRV), a water inlet valve (V4), a water inlet pressure detection sensor (PT1), a Heater (HR), a temperature control sensor ((T1/2/3)) and a degassing pump (P4) which are connected in sequence, wherein an inlet of the Pressure Reducing Valve (PRV) is connected with an R0 pure water supply device, an outlet of the degassing pump (P4) is connected with the feed liquid warming and degassing module (1), and the Heater (HR) is provided with an overtemperature protector (THS).
3. The continuous preparation apparatus of peritoneal dialysis solution, replacement fluid for continuous kidney replacement therapy according to claim 1, characterized in that the continuous dilution proportioning module (2) comprises a first mixing chamber (MC1), a first conductivity sensor (CL1), a second mixing chamber (MC2), a second conductivity sensor (CL2), a third mixing chamber (MC3), and an osmotic pressure sensor (OP1) connected in series, and a liquid B intake line, a liquid A intake line, and a liquid C intake line, the liquid inlet end of the first mixing chamber (MC1) being connected to the liquid outlet end of the warming and degassing module (1) by a pipe, the liquid outlet end of the liquid B intake line being connected to the liquid inlet end of the first mixing chamber (MC1), the liquid outlet end of the liquid A intake line being connected to the liquid inlet end of the second mixing chamber (MC2), the liquid outlet end of the liquid C intake line being connected to the liquid inlet end of the third mixing chamber (MC3), the B liquid suction pipeline is provided with a B liquid pump (P1), the A liquid suction pipeline is provided with an A liquid pump (P2), and the C liquid suction pipeline is provided with a C liquid pump (P3).
4. The apparatus according to claim 3, wherein the inlet of the B-fluid suction line is connected to the outlet of the B-fluid barrel, the inlet of the A-fluid suction line is connected to the outlet of the A-fluid barrel, and the inlet of the C-fluid suction line is connected to the outlet of the C-fluid barrel.
5. The continuous preparation equipment for peritoneal dialysis solution and replacement solution for continuous kidney replacement therapy according to claim 3, wherein an inlet of a solution B suction pipeline is connected with an outlet of a solution B dry powder barrel, an inlet of the solution A suction pipeline is connected with an outlet of the solution A dry powder barrel, an inlet of a solution C suction pipeline is connected with an outlet of the solution C dry powder barrel, and an inlet of the solution B dry powder barrel, an inlet of the solution A dry powder barrel and an inlet of the solution C dry powder barrel are respectively connected with an outlet of the solution inlet warming and degassing module (1).
6. The peritoneal dialysis solution, replacement solution continuous preparation apparatus for continuous kidney replacement therapy according to claim 1, characterized in that the ultrapure filtration module (3) comprises a first filter (CF1), a second filter (CF2) and a detection aid unit, the inlet of the first filter (CF1) is connected with the liquid outlet end of the continuous dilution proportioning module (2), the outlet of the first filter (CF1) is connected with the inlet of the second filter (CF2), the outlet of the second filter (CF2) is connected with the liquid inlet end of the liquid supply module (4), the detection auxiliary unit is respectively connected with the waste liquid outlets of the first filter (CF1) and the second filter (CF2), impurities filtered by the first filter (CF1) and the second filter (CF2) are discharged into the waste liquid discharge pipeline, and the detection auxiliary unit is used for detecting the integrity of filter membranes of the first filter (CF1) and the second filter (CF 2).
7. The continuous preparation apparatus of peritoneal dialysis solution, replacement solution for continuous kidney replacement therapy of claim 6, characterized in that, the detection auxiliary unit comprises an air filter (FL4), a solenoid valve (V11) and a check valve (OW1) connected in sequence, wherein the inlet of the check valve (OW1) is connected with the outlet of the solenoid valve (V11), and the outlet of the check valve (OW1) is connected with the waste liquid outlet of the first filter (CF1) and the second filter (CF2), respectively.
8. The peritoneal dialysis solution, replacement solution continuous preparation equipment for continuous kidney replacement therapy according to claim 1, characterized in that the solution supply module (4) comprises a pressure detector (PT2), a flow pump (P5), a temperature sensor (T2/3), a turbine flow meter (F1) and an external unit which are connected in sequence, the inlet of the pressure detector (PT2) is connected with the outlet end of the ultra-pure filtration module (3), the flow pump (P5) is connected with a back pressure valve (H2) in parallel, the external unit comprises a bypass valve (V9), a first solution supply valve (V7), a second solution supply valve (V8) and a solution supply interface (IF1), the inlet of the bypass valve (V9) is connected with the outlet of the turbine flow meter (F1), the outlet of the bypass valve (V9) is connected with a waste solution discharge pipeline, the inlet of the first solution supply valve (V7) is connected with the inlet of the solution supply valve (V9), and the outlet of the first solution supply valve (V7) is connected with the IF1), an inlet of the second liquid supply valve (V8) is connected with a liquid supply interface (IF1), an outlet of the second liquid supply valve (V8) is connected with an outlet of the bypass valve (V9), an interface sensor S7 is arranged on the liquid supply interface (IF1), and the liquid supply interface (IF1) is used for connecting a sterile liquid storage bag, continuous kidney replacement therapy equipment or peritoneal dialysis therapy equipment.
9. The continuous preparation equipment for peritoneal dialysis solution and replacement solution for continuous kidney replacement therapy according to claim 1, wherein the continuous preparation equipment for peritoneal dialysis solution and replacement solution for continuous kidney replacement therapy further comprises a disinfectant solution suction module (5), and the disinfectant solution suction module (5) is arranged on the waste solution discharge pipeline and is used for disinfecting the whole water path of the equipment and the waste solution of the component.
10. Peritoneal dialysis fluid, replacement fluid continuous preparation equipment for continuous kidney replacement therapy according to claim 9, characterized in that the disinfectant suction module (5) comprises a detection solenoid valve (V10) and a disinfectant tank, the outlet of which is connected to a waste fluid discharge line via a disinfectant solenoid valve (V10).
CN202010163437.2A 2020-03-10 2020-03-10 Continuous preparation equipment of peritoneal dialysis solution and replacement solution for continuous kidney replacement therapy Withdrawn CN111265732A (en)

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CN202010163437.2A CN111265732A (en) 2020-03-10 2020-03-10 Continuous preparation equipment of peritoneal dialysis solution and replacement solution for continuous kidney replacement therapy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010163437.2A CN111265732A (en) 2020-03-10 2020-03-10 Continuous preparation equipment of peritoneal dialysis solution and replacement solution for continuous kidney replacement therapy

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CN111265732A true CN111265732A (en) 2020-06-12

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Application publication date: 20200612