CN105380907A - Acetic acid free bicarbonate dialysate dry powder - Google Patents
Acetic acid free bicarbonate dialysate dry powder Download PDFInfo
- Publication number
- CN105380907A CN105380907A CN201510905822.9A CN201510905822A CN105380907A CN 105380907 A CN105380907 A CN 105380907A CN 201510905822 A CN201510905822 A CN 201510905822A CN 105380907 A CN105380907 A CN 105380907A
- Authority
- CN
- China
- Prior art keywords
- parts
- component
- acetic acid
- dry powder
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- External Artificial Organs (AREA)
Abstract
The invention relates to an acetic acid free bicarbonate dialysate dry powder, which is composed of a component A and a component B; wherein the component A comprises the following components in parts by weight: 100 to 500 parts of critic acid, 600 to 750 parts of glucose, 750 to 1150 parts of sodium chloride, 10 to 50 parts of potassium chloride, 50 to 80 parts of magnesium chloride, and 20 to 80 parts of calcium chloride. The provided acetic acid free bicarbonate dialysate dry powder has the advantages of user-friendliness, safety, and anticoagulant characteristic, does not contain acetic acid, and thus will not cause adverse reactions and short/long term complication.
Description
Technical field
The present invention relates to a kind of hemodialysis product, be specifically related to a kind of bicarbonate dialysis liquid system dry powder without acetic acid.
Background technology
The primary treatments of current renal failure adopts hemodialysis, and hemodialysis is use bicarbonate dialysis liquid system now substantially.Hemodialysis dry powder (being called for short hemodialysis dry powder) is the concentrate formulation for preparing dialysis solution, is made up of component A and B component.Component A forms primarily of sodium chloride, potassium chloride, calcium chloride, magnesium chloride and acidity regulator (organic acid).B component is made up of sodium bicarbonate or sodium bicarbonate and sodium chloride.During use, component A and B component are dissolved into A, B concentrated solution with reverse osmosis water respectively, draw A, B concentrated solution and reverse osmosis water be in proportion respectively mixed with dialysis solution carry out hemodialysis on dialyser by haemodialysis control unit.
Hemodialysis dry powder in the market or hemodialysis concentrated solution mainly adopt acetic acid that biocompatibility is good as acidity regulator.Due to when production hemodialysis dry powder, liquid freon acetic acid volatility is large, is unfavorable for the improvement of production environment, is difficult to again mix homogeneously, deposits process Solid-liquid demixing with other components.In addition, hemodialysis dry powder is in prolonged storage, and acetic acid can penetrate plastic bag film volatilization loss, thus reduces the regulating power of acidity, affects result of use.Therefore, some producer, when production hemodialysis dry powder, does not add acetic acid, and just adds when preparing dialysis solution in clinical hospitals in component A, so namely adds the trouble of hospital's preparation, too increases the chance that preparation dialysis solution is made mistakes.
Summary of the invention
The object of this invention is to provide a kind of bicarbonate dialysis liquid system dry powder without acetic acid, its stable performance, Clinical practice is convenient.
Bicarbonate dialysis liquid system dry powder without acetic acid of the present invention, be made up of component A and B component, described component A comprises the component of following parts by weight:
Wherein, citric acid can be 120 parts, 150 parts, 180 parts, 220 parts, 250 parts, 272 parts, 280 parts, 283 parts, 284 parts, 320 parts, 340 parts, 395 parts, 420 parts, 456 parts, 475 parts, 483 parts or 495 parts;
Glucose can be 620 parts, 650 parts, 685 parts, 700 parts, 720 parts, 726 parts, 730 parts, 735 parts, 740 parts, 742 parts, 745 parts or 750 parts;
Sodium chloride can be 780 parts, 800 parts, 830 parts, 880 parts, 920 parts, 980 parts, 1000 parts, 1020 parts, 1050 parts, 1080 parts, 1100 parts, 1120 parts, 1125 parts, 1130 parts, 1138 parts, 1140 parts, 1143 parts, 1145 parts or 1148 parts;
Potassium chloride can be 13 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, 33 parts, 35 parts, 38 parts, 40 parts, 42 parts, 45 parts or 48 parts;
Magnesium chloride can be 52 parts, 55 parts, 58 parts, 60 parts, 63 parts, 65 parts, 67 parts, 70 parts, 73 parts, 75 parts, 77 parts or 80 parts;
Calcium chloride can be 22 parts, 25 parts, 28 parts, 30 parts, 33 parts, 35 parts, 38 parts, 40 parts, 42 parts, 45 parts, 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts or 78 parts;
Preferably, described component A comprises the component of following parts by weight:
Preferably, described B component comprises the component of following parts by weight:
Sodium bicarbonate 500 ~ 650 parts
0 ~ 200 part, sodium chloride.
Wherein, sodium bicarbonate can be 520 parts, 530 parts, 540 parts, 550 parts, 560 parts, 570 parts, 580 parts, 590 parts, 600 parts, 610 parts, 625 parts, 635 parts, 640 parts or 648 parts;
Sodium chloride can be 20 parts, 50 parts, 80 parts, 100 parts, 108 parts, 110 parts, 115 parts, 120 parts, 130 parts, 140 parts, 150 parts, 160 parts, 170 parts, 180 parts or 190 parts.
Preferably, described B component comprises the component of following parts by weight:
Sodium bicarbonate 550 ~ 600 parts
50 ~ 100 parts, sodium chloride.
The using method of the bicarbonate dialysis liquid system dry powder without acetic acid of the present invention is: component A reverse osmosis water is dissolved into 5 ~ 6L, obtains A dialysis concentrated solution; B component reverse osmosis water is dissolved into 6.5 ~ 10.0L, obtains B dialysis concentrated solution.Haemodialysis control unit is drawn dialyse concentrated solution and B of A by a certain percentage and to be dialysed concentrated solution be diluted to dialysis solution with reverse osmosis water and use.
Compared with prior art, the invention has the advantages that: the bicarbonate dialysis liquid system dry powder without acetic acid of the present invention not containing liquid freon acetic acid, thus overcomes the many harmful effects of use liquid freon acetic acid in dialysis dry powder production, storage process.Replace liquid freon acetic acid in the production process of hemodialysis dry powder with solid citric acid, can be mixed together evenly with other salts, production operation is easy, and quality easily controls.
In a word, the bicarbonate dialysis liquid system dry powder without acetic acid of the present invention uses simple and safe, has both had anticoagulant characteristic, the untoward reaction caused without acetic acid again and nearly long term complication.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1
The bicarbonate dialysis liquid system dry powder without acetic acid of the present embodiment, is made up of component A and B component.
Wherein, component A comprises the component of following parts by weight:
B component comprises the component of following parts by weight: only containing the sodium bicarbonate of 500 parts.
Embodiment 2
The bicarbonate dialysis liquid system dry powder without acetic acid of the present embodiment, is made up of component A and B component.
Wherein, component A comprises the component of following parts by weight:
B component comprises the component of following parts by weight:
Sodium bicarbonate 600 parts
100 parts, sodium chloride.
Embodiment 3
The bicarbonate dialysis liquid system dry powder without acetic acid of the present embodiment, is made up of component A and B component.
Wherein, component A comprises the component of following parts by weight:
B component comprises the component of following parts by weight:
Sodium bicarbonate 650 parts
200 parts, sodium chloride.
Above content is only preferred embodiment of the present invention, and for those of ordinary skill in the art, according to thought of the present invention, all will change in specific embodiments and applications, this description should not be construed as limitation of the present invention.
Claims (4)
1. without a bicarbonate dialysis liquid system dry powder for acetic acid, be made up of component A and B component, it is characterized in that: described component A comprises the component of following parts by weight:
2. the bicarbonate dialysis liquid system dry powder without acetic acid according to claim 1, is characterized in that: described component A comprises the component of following parts by weight:
3. the bicarbonate dialysis liquid system dry powder without acetic acid according to claim 1 and 2, is characterized in that: described B component comprises the component of following parts by weight:
Sodium bicarbonate 500 ~ 650 parts
0 ~ 200 part, sodium chloride.
4. the bicarbonate dialysis liquid system dry powder without acetic acid according to claim 3, is characterized in that: described B component comprises the component of following parts by weight:
Sodium bicarbonate 550 ~ 600 parts
50 ~ 100 parts, sodium chloride.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510905822.9A CN105380907A (en) | 2015-12-09 | 2015-12-09 | Acetic acid free bicarbonate dialysate dry powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510905822.9A CN105380907A (en) | 2015-12-09 | 2015-12-09 | Acetic acid free bicarbonate dialysate dry powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105380907A true CN105380907A (en) | 2016-03-09 |
Family
ID=55414089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510905822.9A Pending CN105380907A (en) | 2015-12-09 | 2015-12-09 | Acetic acid free bicarbonate dialysate dry powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105380907A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823217A (en) * | 2017-11-24 | 2018-03-23 | 安徽金阳光农业服务有限公司 | Compound NaCl dissipate and preparation method thereof |
| CN109091499A (en) * | 2018-08-31 | 2018-12-28 | 山东威高药业股份有限公司 | A kind of preparation process of haemodialysis concentrate A powder |
| CN110327371A (en) * | 2019-07-15 | 2019-10-15 | 武汉大学 | Sodium bicarbonate ringer's injection and preparation method thereof |
| CN113057962A (en) * | 2021-03-26 | 2021-07-02 | 广州骐骥生物科技有限公司 | Novel citric acid bicarbonate hemodialysis dry powder and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6251437B1 (en) * | 1999-07-13 | 2001-06-26 | Minntech Corporation | Liquid/powder acid concentrate for dialysate and a method of making the same |
| CN1919363A (en) * | 2006-09-15 | 2007-02-28 | 天津市肾友达医疗设备技术开发有限公司 | Novel dialytic concentrating preparation |
| CN103796634A (en) * | 2011-06-20 | 2014-05-14 | 甘布罗伦迪亚股份公司 | Dialysis precursor composition |
-
2015
- 2015-12-09 CN CN201510905822.9A patent/CN105380907A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6251437B1 (en) * | 1999-07-13 | 2001-06-26 | Minntech Corporation | Liquid/powder acid concentrate for dialysate and a method of making the same |
| CN1919363A (en) * | 2006-09-15 | 2007-02-28 | 天津市肾友达医疗设备技术开发有限公司 | Novel dialytic concentrating preparation |
| CN103796634A (en) * | 2011-06-20 | 2014-05-14 | 甘布罗伦迪亚股份公司 | Dialysis precursor composition |
Non-Patent Citations (1)
| Title |
|---|
| 刘学军，等: "《血液透析实用技术手册（第2版）》", 31 July 2010, 中国协和医科大学出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823217A (en) * | 2017-11-24 | 2018-03-23 | 安徽金阳光农业服务有限公司 | Compound NaCl dissipate and preparation method thereof |
| CN109091499A (en) * | 2018-08-31 | 2018-12-28 | 山东威高药业股份有限公司 | A kind of preparation process of haemodialysis concentrate A powder |
| CN110327371A (en) * | 2019-07-15 | 2019-10-15 | 武汉大学 | Sodium bicarbonate ringer's injection and preparation method thereof |
| CN110327371B (en) * | 2019-07-15 | 2021-07-06 | 武汉大学 | Sodium bicarbonate ringer's injection and preparation method thereof |
| CN113057962A (en) * | 2021-03-26 | 2021-07-02 | 广州骐骥生物科技有限公司 | Novel citric acid bicarbonate hemodialysis dry powder and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105380907A (en) | Acetic acid free bicarbonate dialysate dry powder | |
| JP5876042B2 (en) | Dialysis precursor composition | |
| CA2803432C (en) | Dialysis precursor composition | |
| CN102038978A (en) | Hemodialysis concentrate | |
| CA2836371C (en) | Dialysis precursor composition | |
| WO2013152309A8 (en) | Ambulatory lung assist device with implanted blood pump and oxygenator | |
| US9821102B2 (en) | Dialysis precursor composition | |
| CN108066356A (en) | A kind of haemodialysis concentrate | |
| JP2022084627A (en) | System for proportioning fluids | |
| CN1448145A (en) | Bicarbonate dry powder composition for hemodialysis | |
| CN105434460A (en) | Medical pure sodium bicarbonate dialysis dry powder | |
| PH12016500572A1 (en) | Solid dialysis a agent containing alkali metal diacetate, and two-part type low-acetate dialysis agent using same | |
| CN105434461A (en) | Bicarbonate dialyzate dry powder composition | |
| EP2934483A1 (en) | Dialysis composition | |
| CA2855889C (en) | Dialysis precursor composition | |
| KR100993178B1 (en) | Concentrate containing citric acid and low level acetic acid | |
| CN203915592U (en) | Nursing cover for hemodialysis | |
| CN104010645B (en) | Dialysis precursor composition | |
| CN204468823U (en) | A kind of Urology Department haemodialysis equipment | |
| CN113456667A (en) | High-purity hemodialysis concentrated solution and preparation process thereof | |
| JP2018510019A5 (en) | ||
| CN104434963A (en) | Chromium-supplemented dialysis concentrate | |
| BRPI1104153A2 (en) | Ready-to-use electrolyte formulation, ready-to-use pouch, kit, uses and method of treating renal failure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160309 |