CN105434459A - Formula of western medicine for treating ulcer and preparation process for western medicine - Google Patents
Formula of western medicine for treating ulcer and preparation process for western medicine Download PDFInfo
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- CN105434459A CN105434459A CN201511022214.XA CN201511022214A CN105434459A CN 105434459 A CN105434459 A CN 105434459A CN 201511022214 A CN201511022214 A CN 201511022214A CN 105434459 A CN105434459 A CN 105434459A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/08—Oxides; Hydroxides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
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- General Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a formula of a western medicine for treating ulcer and a preparation process for the western medicine. The western medicine is prepared from the following raw materials in parts by weight: 18-22 parts of aluminium hydroxide, 10-15 parts of sucralfate, 6-10 parts of tetracycline, 1-4 parts of vitamin B2, 1-4 parts of vitamin B6, 3-7 parts of vitamin C and 8-12 parts of metronidazole. The western medicine has the advantages of taking effects quickly, being good in treatment effect, having no toxic or side effects and having an excellent effect on gastric ulcer, duodenal ulcer and other diseases.
Description
Technical field
The present invention relates to a kind of Western medicine, be specifically related to a kind of Western medicine formula for the treatment of ulcer and preparation method thereof.
Background technology
Defect caused by the destruction that ulcer is knitted for corium or deep skin, has guarantor's trace more afterwards.Ulcer is secondary lesion, every skin injury, infects or infringement that tuberosity ulceration reaches certain depth can cause the generation of ulcer.
Ulcer is generally the limitation Skin preparation caused by wound, infected by microbes, tumor, circulatory disturbance and delayed ischemic neurological deficits, immunologic dysfunction or congenital skin injury etc.Traumatic ulcer directly acts on tissue by physics and chemistry factor often to be caused.Microbial infectious diseases is many causes disorganization by antibacterial, fungus, spirillum, virus etc.Tuberosity or tumor ulceration.The vasculitic ulcer system that dysimmunity causes is formed because tremulous pulse or arteriolitis make tissue necrose.Circulation or delayed ischemic neurological deficits belong to malnutrition and cause tissue necrosis, as varicosis, leprelcosis etc.
Peptic ulcer is divided into gastric ulcer and duodenal ulcer according to happening part difference.
The medicament categories of present treatment ulcer is a lot, and various medicine has good curative effect for the ulcer of different pathogeny, but easily recurs after ulcer recovery from illness, and the medical history of ulcers is long, and constantly repeatedly, after Drug therapy takes effect, the probability of recurrence is very large.
A kind of Western medicine formula for the treatment of ulcer of the present invention, instant effect, therapeutic effect is good, has no side effect, to the disease such as gastric ulcer, duodenal ulcer best results.
Summary of the invention
The present invention relates to a kind of the Western medicine formula and the preparation technology thereof that treat ulcer, mainly taking effect slowly to overcome general ulcer treatment medicine, the shortcoming of easily recurrence after ulcer recovery from illness.
Technical scheme of the present invention is: a kind of Western medicine formula for the treatment of ulcer, and it is made up according to following weight of each raw material: aluminium hydroxide 18 to 22 parts, sucralfate 10 to 15 parts, tetracycline 6 to 10 parts, vitamin B
21 to 4 part, vitamin B
61 to 4 part, vitamin C 3 to 7 parts, metronidazole 8 to 12 parts.
Described a kind of Western medicine formula and preparation technology thereof treating ulcer, it is made up according to following weight proportion of each raw material: aluminium hydroxide 20 parts, sucralfate 14 parts, tetracycline 8 parts, vitamin B
23 parts, vitamin B
63 parts, vitamin C 4 parts, metronidazole 10 parts.
The preparation technology of the Western medicine of described treatment ulcer, comprises the following steps:
Step 1: get raw material, each raw material is according to following weight proportion: aluminium hydroxide 18 to 22, sucralfate 10 to 15 parts, tetracycline 6 to 10 parts, vitamin B
21 to 4 part, vitamin B
61 to 4 part, vitamin C 3 to 7 parts, metronidazole 8 to 12 parts;
Step 2: the raw material of step 1 is put into pulverizer and pulverize, stir, filter through 200 mesh filter screens;
Step 3: mixed-powder step 2 obtained adds normal saline mixing patent medicine mud, and medicine mud is made granule through granule machine, each powder 2 grams, dry, packaging.
Cure mainly function: gastric ulcer, duodenal ulcer.
Usage and dosage: be grown up three times on the one, take before the meal, each 2, take and take effect for 2 ~ 3 days, pain relief, take about one week, recovery from illness, period in a medicine avoids tobacco and wine, avoids irritable food.
Beneficial effect of the present invention:
Peptic ulcer is one of commonly encountered diseases in population of China, frequently-occurring disease.Be apt to occur in the winter and spring that climate change is larger.Male's sickness rate is apparently higher than women.Abnormal with gastric acid secretion, helicobacter pylori (H.pylori) infects, NSAID (non-steroidal anti-inflammatory drug) (NSAID), live and diet is irregular, work and ambient pressure, smoking, drink and psychologic factors closely related.The present invention uses: aluminium hydroxide is used for the treatment of hyperchlorhydria, and the main component of gastric acid is hydrochloric acid, utilizes aluminium hydroxide and gastric acid to react to generate nontoxic aluminum chloride to excrete; Sucralfate: be effective antiulcer drug, has protection ulcer surface, promotes the effect of ulcer healing.Its mechanism of action is under sour environment, dissociate sulphuric acid sucrose compound ion, compound ion aggregates into insoluble electronegative colloid, can combine by the protein exudate positively charged with ulcer surface, form layer protecting film and be covered in ulcer surface, promote ulcer healing, also there is absorption pepsin and bile acid effect; Tetracycline: there is bactericidal action; Vitamin: vitimin supplement; Metronidazole: have killing action to anaerobe, the metabolite generated when it reduces in human body also has anaerobe resistant effect, the synthesis of the DNA (deoxyribonucleic acid) of anti-bacteria, thus disturbs growth, the breeding of antibacterial, finally causes bacterial death; During the present invention passes through and gastric acid, vitimin supplement, kills pathogenic bacteria, and protection ulcer affected part reaches the object for the treatment of ulcer.
Below in conjunction with clinical testing data analysis.
This group is totally 150 patients w ith peptic ulcer diseases (wherein female patient 27) and 100 duodenal ulcer patients (wherein female patient 11), and this group case all has ill for a long time, the medical history of recurrent exerbation, 27 ~ 63 years old age.150 patients w ith peptic ulcer diseases are divided into A, B, C tri-groups at random, often organize 50 people; 100 duodenal ulcer patients are divided into I, II, III tri-groups at random, often organize 33 people, Group III 34 people.
Criterion of therapeutical effect: according to " guideline of clinical investigations of new Chinese medicine treatment peptic ulcer " regulation, gastroscopy effect criterion: (1) clinical recovery: ulcer disappears completely, local mild hyperaemia, without obvious edema.(2) effective: ulcer disappears substantially, still have obvious inflammation.(3) effective: ulcer surface reduces more than 50%.(4) invalid: ulcer surface reduces not as good as 50%.
Therapeutic Method:
The present invention tests gastric ulcer therapeutic effect:
A group takes the obtained drug particles of the embodiment of the present invention 1, every day three times, bfore meals, each 2.
B group takes the obtained drug particles of the embodiment of the present invention 2, every day three times, bfore meals, each 2.
C group takes the medicine of any current therapies gastric ulcer for matched group.
Above three groups of courses for the treatment of are one week.
Therapeutic outcome is as following table:
| Group | Toxic and side effects | To no effect | Effectively | Recovery from illness | Total effective rate |
| A | 0 | 2 | 16 | 32 | 96％ |
| B | 0 | 1 | 13 | 36 | 98％ |
| Matched group C | 0 | 6 | 21 | 13 | 88％ |
The present invention can test by therapeutic effect duodenum:
I group takes the obtained drug particles of the embodiment of the present invention 1, every day three times, bfore meals, each 2.
II group takes the obtained drug particles of the embodiment of the present invention 2, every day three times, bfore meals, each 2.
III group takes the medicine of any current therapies duodenal ulcer for matched group.
Above three groups of courses for the treatment of are one week.
| Group | Toxic and side effects | To no effect | Effectively | Recovery from illness | Total effective rate |
| I | 0 | 4 | 13 | 16 | 87.88％ |
| II | 0 | 3 | 8 | 22 | 90.91％ |
| Control Group II I | 0 | 9 | 15 | 10 | 73.53％ |
Clinical model case:
Case 1, patients w ith peptic ulcer disease journey, man, 43 years old, has a stomach-ache 8 years repeatedly, this patient work's pressure is larger, smoking and drinking at ordinary times, nearest two weeks is in a bad way, 1.5 hours left upper abdomen pain after feed, find through hospital gastroscope inspection, coat of the stomach is shown in that diameter is about the ulcer of 15mm, surface hyperemia, edema.
To take after Western medicine of the present invention one week, stomach pain disappears, and diet is normal, and gastroscopy shows, and ulcer disappears completely, clinical recovery.
Case 2, duodenal ulcer patients week certain, man, 35 years old, be engaged in sale, this patient works busy at ordinary times, and diet is irregular, and often drink in guest invited to a dinner party family, suffers from duodenal ulcer 3 years, within nearest one week, be in a bad way, to certain examination in hospital, be diagnosed as duodenal ulcer.
To take after Western medicine of the present invention one week, pain disappears, and diet is normal, and ulcer disappears completely, clinical recovery.
Detailed description of the invention
Below in conjunction with example, the present invention will be further described.
Embodiment 1
Treat a Western medicine formula for ulcer, it is made up according to following weight of each raw material: aluminium hydroxide 20 parts, sucralfate 14 parts, tetracycline 8 parts, vitamin B
23 parts, vitamin B
63 parts, vitamin C 4 parts, metronidazole 10 parts.
The preparation technology of the Western medicine of described treatment ulcer, comprises the following steps:
Step 1: get raw material, each raw material is according to following weight proportion: aluminium hydroxide 20 parts, sucralfate 14 parts, tetracycline 8 parts, vitamin B
23 parts, vitamin B
63 parts, vitamin C 4 parts, metronidazole 10 parts;
Step 2: the raw material of step 1 is put into pulverizer and pulverize, stir, filter through 200 mesh filter screens;
Step 3: mixed-powder step 2 obtained adds normal saline mixing patent medicine mud, and medicine mud is made granule through granule machine, each powder 2 grams, dry, packaging.
Cure mainly function: gastric ulcer, duodenal ulcer.
Usage and dosage: be grown up three times on the one, take before the meal, each 2, take and take effect for 2 ~ 3 days, pain relief, take about one week, recovery from illness, period in a medicine avoids tobacco and wine, avoids irritable food.
Embodiment 2
Treat a Western medicine formula for ulcer, it is made up according to following weight proportion of each raw material: aluminium hydroxide 19 parts, sucralfate 12 parts, tetracycline 8 parts, vitamin B
22 parts, vitamin B
63 parts, vitamin C 5 parts, metronidazole 9 parts.
The preparation technology of the Western medicine of described treatment ulcer, comprises the following steps:
Step 1: get raw material, each raw material is according to following weight proportion: aluminium hydroxide 19 parts, sucralfate 12 parts, tetracycline 8 parts, vitamin B
22 parts, vitamin B
63 parts, vitamin C 5 parts, metronidazole 9 parts;
Step 2: the raw material of step 1 is put into pulverizer and pulverize, stir, filter through 200 mesh filter screens;
Step 3: mixed-powder step 2 obtained adds normal saline mixing patent medicine mud, and medicine mud is made granule through granule machine, each powder 2 grams, dry, packaging.
Cure mainly function: gastric ulcer, duodenal ulcer.
Usage and dosage: be grown up three times on the one, take before the meal, each 2, take and take effect for 2 ~ 3 days, pain relief, take about one week, recovery from illness, period in a medicine avoids tobacco and wine, avoids irritable food.
Claims (4)
1. treat a Western medicine formula for ulcer, it is characterized in that, it is made up according to following weight of each raw material: aluminium hydroxide 18 to 22 parts, sucralfate 10 to 15 parts, tetracycline 6 to 10 parts, vitamin B
21 to 4 part, vitamin B
61 to 4 part, vitamin C 3 to 7 parts, metronidazole 8 to 12 parts.
2. treat a preparation technology for the Western medicine formula of ulcer, it is characterized in that, it comprises the following steps:
Step 1: get raw material, each raw material is according to following weight proportion: aluminium hydroxide 18 to 22, sucralfate 10 to 15 parts, tetracycline 6 to 10 parts, vitamin B
21 to 4 part, vitamin B
61 to 4 part, vitamin C 3 to 7 parts, metronidazole 8 to 12 parts;
Step 2: the raw material of step 1 is put into pulverizer and pulverize, stir, filter through 200 mesh filter screens;
Step 3: mixed-powder step 2 obtained adds normal saline mixing patent medicine mud, and medicine mud is made drug particles through granule machine, and each powder weighs 2 grams, dry, packaging.
3. a kind of preparation technology treating the Western medicine formula of ulcer as claimed in claim 2, it is characterized in that, described powder is each heavy 2 grams.
4. a kind of Western medicine formula for the treatment of ulcer as claimed in claim 1, is characterized in that, primary treatment gastric ulcer and duodenal ulcer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511022214.XA CN105434459A (en) | 2015-12-25 | 2015-12-25 | Formula of western medicine for treating ulcer and preparation process for western medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511022214.XA CN105434459A (en) | 2015-12-25 | 2015-12-25 | Formula of western medicine for treating ulcer and preparation process for western medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105434459A true CN105434459A (en) | 2016-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201511022214.XA Pending CN105434459A (en) | 2015-12-25 | 2015-12-25 | Formula of western medicine for treating ulcer and preparation process for western medicine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106492205A (en) * | 2016-12-02 | 2017-03-15 | 郑州莉迪亚医药科技有限公司 | A kind of medicine for gastric ulcer and preparation method thereof |
| CN106860852A (en) * | 2017-02-17 | 2017-06-20 | 王清华 | A kind of mucus Western medicine for combined treatment stomach trouble |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999056698A2 (en) * | 1998-05-06 | 1999-11-11 | Københavns Universitet | Treatment of celiac disease |
| CN1425424A (en) * | 2002-12-25 | 2003-06-25 | 丁心河 | Specific remedy for curing duodenal and gastric ulcer |
-
2015
- 2015-12-25 CN CN201511022214.XA patent/CN105434459A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999056698A2 (en) * | 1998-05-06 | 1999-11-11 | Københavns Universitet | Treatment of celiac disease |
| CN1425424A (en) * | 2002-12-25 | 2003-06-25 | 丁心河 | Specific remedy for curing duodenal and gastric ulcer |
Non-Patent Citations (2)
| Title |
|---|
| 彭金咏: "《国家基本药物知识与技能》", 31 October 2012, 军事医学科学出版社 * |
| 王蔚虹等: "幽门螺杆菌感染治疗的研究现状", 《中国新药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106492205A (en) * | 2016-12-02 | 2017-03-15 | 郑州莉迪亚医药科技有限公司 | A kind of medicine for gastric ulcer and preparation method thereof |
| CN106860852A (en) * | 2017-02-17 | 2017-06-20 | 王清华 | A kind of mucus Western medicine for combined treatment stomach trouble |
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Application publication date: 20160330 |