CN105434334A - Active carbon suppository used for treating cervical erosion, and preparation method thereof - Google Patents
Active carbon suppository used for treating cervical erosion, and preparation method thereof Download PDFInfo
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- CN105434334A CN105434334A CN201510960494.2A CN201510960494A CN105434334A CN 105434334 A CN105434334 A CN 105434334A CN 201510960494 A CN201510960494 A CN 201510960494A CN 105434334 A CN105434334 A CN 105434334A
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- solution
- active carbon
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- suppository
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/44—Elemental carbon, e.g. charcoal, carbon black
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
Abstract
The invention discloses an active carbon suppository used for treating cervical erosion, and a preparation method thereof. The preparation method comprises following steps: water, a nano-silver aqueous solution, and Carbopol are uniformly mixed, an obtained mixture is heated to 65 to 75 DEG C, and mixed fatty glyceride is added for uniform mixing so as to obtain a mixed solution; sodium carboxymethylcellulose, hydroxy propyl cellulose, and active carbon are uniformly mixed, the mixed solution is added, and a paste is obtained via stirring; the paste is injected into a mould via pressurization, is refrigerated so as to realize shape preserving, and then is taken out from the mould; an obtained product is heated for 2 to 6h at 60 to 90 DEG C, and then is heated for 0.5 to 2.5h at 110 to 120 DEG C; and at last an obtained finished product is packaged with medical absorbent gauze. Adsorption speed of the active carbon suppository is high; adsorption capacity is high; adsorption quantity is large; pathogenic bacteria and virus can be adsorbed into fiber holes, so that the survival environment of the pathogenic bacteria and virus is changed, the pathogenic bacteria and virus are killed, inflammation diminishing, pain relieving, bleeding stopping, deodorization, and sterilization are realized, cell growth is promoted, tissue regeneration is accelerated, diseases are treated, and no bacterial drug resistance is induced.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of active carbon suppository for the treatment of cervical erosion and preparation method thereof.
Background technology
Vaginitis can be divided into following five kinds: bacterial vaginosis, monilial vaginitis, trichomonal vaginitis, senile vaginitis, infantile vaginitis.
The bacterial vaginosis mainly per vaginam microbial a kind of vaginitis in Gartner, passability relation is propagated.Bacterial vaginosis is that Gartner bacterium, anaerobe etc. increase, and lactobacillus reduces, the disease that intravaginal ecological balanced system changes and causes.Wherein, also there is Gartner bacterium parasitic in healthy women vagina.
Colpitis mycotica or monilial vaginitis and false silk candidiasis (VVC) of vulvovaginal are by the microbial a kind of common multiple vulvovaginal inflammation disease of beads.Candida albicans is conditioned pathogen, have this bacterium parasitic, but bacterium amount is few, does not cause symptom in the Newborn of 10-20% and anemia of pregnant woman's vagina of 30%.Only have when whole body and vagina local immunity ability decline, especially local cells immunity degradation, Candida albicans amount reproduction, just can cause vaginitis symptom.
Trichomonal vaginitis is caused by trichomonacide, and the trichomonacide of parasitic human body has trichomonal vaginitis, Trichomonas hominis and buccalis, parasitizes genitourinary system, intestinal and oral cavity respectively, and relevant with dermatosis is trichomonal vaginitis, causes trichomonal vaginitis.Be a kind of parasitic disease propagated mainly through sexual intercourse, there is infectiousness.
Senile vaginitis is common in postclimacteric elderly woman, and because of ovarian failure, estrogen level reduces, vaginal wall atrophy, mucosa is thinning, and in epithelial cell, glycogen content reduces, intravaginal pH value rises, and local resistance reduces, and pathogenic bacterium are easily invaded breeding and cause inflammation.Cardinal symptom is that vaginal secretions increases and pruritus vulvae, burning sensation.Inspection is shown in that vagina is senile change, epithelial atrophy, and pleat disappears, and epithelium flattens sliding, poor.Vaginal mucosa is congested, has little petechia, sometimes sees shallow table ulcer.If ulcer surface and offside adhesion, during examination per vagina, adhesion can separately be caused bleeding, and can cause stricture of vagina even locking when adhesion is serious, inflammation secretions inadequate drainage can form pyrocolpos even pyometra, and current this situation is rare.
Infantile vaginitis mostly occurs the youngest daughter in 2-9 year, is the commonly encountered diseases of women's infant.Because vaginitis is many with vulvitis, therefore, infant vulvovaginitis is often referred to as.
Be used for the treatment of colpitic medicament base and be originally divided into two large class, medicine for external use and oral medicines.Medicine for external use is mainly divided into lotion class, suppository class and effervescent tablet class.The invention provides a kind of active carbon suppository for the treatment of cervical erosion, can anti-bacteria rapidly, simultaneously in use safety, effectively, have no side effect and not easily produce drug resistance.
Summary of the invention
For the deficiencies in the prior art, one of technical problem to be solved by this invention is to provide a kind of preparation method for the treatment of the active carbon suppository of cervical erosion.
Two of technical problem to be solved by this invention is to provide the active carbon suppository for the treatment of cervical erosion prepared by said method.
For achieving the above object, the technology used in the present invention solution is:
A kind of preparation method for the treatment of the active carbon suppository of cervical erosion, by 98-102 part water, 0.4-0.6 part nano-silver water solution, 0.8-1.2 part carbomer mix homogeneously, be heated to 65-75 DEG C, add 5-7 part mixed fatty glycerides mix homogeneously, obtain mixed solution; 3-5 part sodium carboxymethyl cellulose, 6-9 part hydroxypropyl cellulose are mixed homogeneously with 78-82 part active carbon, add above-mentioned mixed solution, stir into dough, mould is injected in pressurization, freezing maintenance shape, takes out; At 65-85 DEG C, heat 2-6 hour, then at 105-115 DEG C of heating 0.5-2.5 hour, finally wrap up medical absorbent cotton/gauze.
Preferably,
Described mixed fatty glycerides is mixed by tricaprylin, decanoin, myristin, and the mass ratio of described tricaprylin, decanoin, myristin is (1-3): (1-3): (1-3).
In described nano-silver water solution, the mass concentration of nanometer silver is 85-115 μ g/mL; Described nano-silver water solution is prepared from by following method: by silver nitrate dissolution of solid in water, and preparation obtains solution A, and in solution A, the mass concentration of silver nitrate is 20-40mg/mL; Carboxymethyl cellulose sodium and sodium carboxymethyl cellulose are dissolved in the water, preparation obtains solution B, and in solution B, the mass concentration of Carboxymethyl cellulose sodium is 0.1-0.5mg/mL, and in solution B, the mass concentration of sodium carboxymethyl cellulose is 0.1-0.5mg/mL; Get 0.05-0.2mL solution A to mix with 15-25mL solution B, control its pH value between 7-11, at 20-80 DEG C, react 3-18 hour, obtain described nano-silver water solution.
Described hydroxypropyl cellulose is low-substituted hydroxypropyl cellulose.
Present invention also offers a kind of active carbon suppository for the treatment of cervical erosion, be prepared from by said method.
Concrete, in the present invention:
Active carbon, No. CAS: 64365-11-3.
Carbomer, No. CAS: 54182-57-9.
Sodium carboxymethyl cellulose, No. CAS: 9004-32-4.
Hydroxypropyl cellulose, No. CAS: 9004-64-2.
Tricaprylin, No. CAS: 538-23-8.
Decanoin, No. CAS: 621-71-6.
Myristin, No. CAS: 555-45-3.
Silver nitrate, No. CAS: 7761-88-8.
Carboxymethyl cellulose sodium, No. CAS: 9085-26-1.
A kind of active carbon for the treatment of in the active carbon suppository of cervical erosion of the present invention has the advantages that adsorption rate is fast, absorption affinity is strong, adsorbance is large, by various malignant bacteria, viruses adsorption in fiber holes, change its living environment, make it dead, thus reach antiinflammatory, pain relieving, hemostasis, deodorization, sterilizing, Promote cell's growth accelerates tissue regeneration, the effect of cure diseases, and antibacterial can not be made to produce drug resistance.Activated carbon adsorption bolt of the present invention is well-designed according to female pathology structure, adopt built-in suppository type, be placed in the product that intravaginal is used for the treatment of colpitis, be mainly used in the inflammation such as treatment VVC, nonspecific vaginitis, bacterial vaginosis, do not destroy the normal environment of vagina, do not affect the growth of lactobacillus, have no drug resistance, antibacterial stable, has a broad antifungal spectrum, compliance that is easy to use, comfortable, pollution-free, patient is good.
Detailed description of the invention
Embodiment 1
Prepared by nano-silver water solution: joined in 10mL deionized water by 0.32g silver nitrate and make solution A; Join in 20mL deionized water by the sodium carboxymethyl cellulose of 0.005g and 0.005g Carboxymethyl cellulose sodium, rotating speed 200r/min stirs 30min and dissolves, and adjust ph, 8, makes solution B; Getting solution A 0.1mL joins in solution B, is placed in water-bath and is heated to 60 DEG C; Stirring reaction, after 4 hours, obtains nano-silver water solution, and the nano-Ag particles mean diameter obtained is less than 100 nanometers, and in nano-silver water solution, the mass concentration of nanometer silver is 101 μ g/mL.
The active carbon suppository preparation for the treatment of cervical erosion:
In 100g deionized water, add 0.5g nano-silver water solution mix homogeneously, under rotating speed 100r/min stirring condition, add 1g carbomer, mix homogeneously, be heated to 70 DEG C, add 6g mixed fatty glycerides mix homogeneously, obtain mixed solution; 4g sodium carboxymethyl cellulose, 7g low-substituted hydroxypropyl cellulose (model adopting Hubei Jian Yuan Chemical Co., Ltd. is the low-substituted hydroxypropyl cellulose of LH-21) are mixed homogeneously with 80g active carbon, add above-mentioned mixed solution, stir into dough, mould is injected in pressurization, freezing maintenance shape, takes out; Heat 4 hours at 80 DEG C, again 110 DEG C of heating 1 hour, finally wrap up gauze (article No. adopting Yancheng City Xin Feng medical supplies company limited to produce is the medical absorbent cotton/gauze of YYSB-002), the two aluminum composite membrane bag sealing of dress, ethane via epoxyethane sterilization, 1.5 grams every.
Described mixed fatty glycerides is mixed by 2g tricaprylin, 2g decanoin, 2g myristin.
Embodiment 2
By the active carbon suppository of the method preparation treatment cervical erosion of embodiment 1, difference is only: described mixed fatty glycerides is mixed by 3g tricaprylin, 3g decanoin.Obtain the active carbon suppository of the treatment cervical erosion of embodiment 2,1.5 grams every.
Embodiment 3
By the active carbon suppository of the method preparation treatment cervical erosion of embodiment 1, difference is only: described mixed fatty glycerides is mixed by 3g tricaprylin, 3g myristin.Obtain the active carbon suppository of the treatment cervical erosion of embodiment 3,1.5 grams every.
Embodiment 4
By the active carbon suppository of the method preparation treatment cervical erosion of embodiment 1, difference is only: described mixed fatty glycerides is mixed by 3g decanoin, 3g myristin.Obtain the active carbon suppository of the treatment cervical erosion of embodiment 4,1.5 grams every.
Embodiment 5
By the active carbon suppository of the method preparation treatment cervical erosion of embodiment 1, difference is only: prepared by nano-silver water solution: joined in 10mL deionized water by 0.32g silver nitrate and make solution A; Joined by the sodium carboxymethyl cellulose of 0.01g in 20mL deionized water, rotating speed 200r/min stirs 30min and dissolves, and adjust ph, between 7-9, makes solution B; Getting solution A 0.1mL joins in solution B, is placed in water-bath and is heated to 60 DEG C; Stirring reaction, after 4 hours, obtains nano-silver water solution, and the nano-Ag particles mean diameter obtained is less than 100 nanometers, and in nano-silver water solution, the mass concentration of nanometer silver is 101.6 μ g/mL.Obtain the active carbon suppository of the treatment cervical erosion of embodiment 5,1.5 grams every.
Embodiment 6
By the active carbon suppository of the method preparation treatment cervical erosion of embodiment 1, difference is only: prepared by nano-silver water solution: joined in 10mL deionized water by 0.32g silver nitrate and make solution A; Joined by 0.01g Carboxymethyl cellulose sodium in 20mL deionized water, rotating speed 200r/min stirs 30min and dissolves, and adjust ph, between 7-9, makes solution B; Getting solution A 0.1mL joins in solution B, is placed in water-bath and is heated to 60 DEG C; Stirring reaction, after 4 hours, obtains nano-silver water solution, and the nano-Ag particles mean diameter obtained is less than 100 nanometers, and in nano-silver water solution, the mass concentration of nanometer silver is 101.6 μ g/mL.Obtain the active carbon suppository of the treatment cervical erosion of embodiment 6,1.5 grams every.
Test case 1
Therapeutic effect test is carried out to the active carbon suppository of the treatment cervical erosion that embodiment 1-6 obtains, select hospital outpatient age 20-60 year cervical erosion III degree of patient 300, be divided into 6 groups at random, often organize 50, the active carbon suppository of the treatment cervical erosion using embodiment 1-6 to obtain respectively, every day 1, be positioned over vagina deep before sleeping 8 hours, within 14 days, detect conditions of patients improved condition afterwards.Concrete data are in table 1.
Table 1: conditions of patients tables of data
Found out by table 1, comparing embodiment 1 and embodiment 2-4, embodiment 1 (mixed fatty glycerides employing tricaprylin, decanoin, myristin are composite) therapeutic effect is obviously better than embodiment 2-4 (in mixed fatty glycerides employing tricaprylin, decanoin, myristin, the two is composite arbitrarily); Comparing embodiment 1 and embodiment 5-6, embodiment 1 (nano-silver water solution preparation adopt sodium carboxymethyl cellulose and Carboxymethyl cellulose sodium composite) therapeutic effect is obviously better than embodiment 5-6 (nano-silver water solution preparation adopts single raw material in sodium carboxymethyl cellulose and Carboxymethyl cellulose sodium).
Test case 2
The change of active carbon suppository quality index under accelerated test condition of the treatment cervical erosion that testing example 1-6 obtains.
The active carbon suppository of the treatment cervical erosion obtained by embodiment 1-6 carries out accelerated test in equal conditions, temperature is 40 ± 2 DEG C, place 6 months in the constant temperature humidity chamber of relative humidity 75 ± 5%, sample respectively once 1st month, the 2nd month, the 3rd month, the 6th the end of month at duration of test, by regulation investigate preparation color, melt become the time limit, afterbody particle, content of nanometer silver, stability result is in Table 2-5.
Table 2: the 1st month accelerated test stability result table
| Color | Melt and become the time limit (min) | Appearance | Content of nanometer silver (μ g) | |
| Embodiment 1 | Milky | 42 | Moist | 50.5 |
| Embodiment 2 | Milky | 44 | Moist | 50.5 |
| Embodiment 3 | Milky | 45 | Moist | 50.5 |
| Embodiment 4 | Milky | 47 | Moist | 50.4 |
| Embodiment 5 | Milky | 43 | Moist | 50.5 4 --> |
| Embodiment 6 | Milky | 47 | Moist | 50.3 |
Table 3: the 2nd month accelerated test result table
Table 4: the 3rd month accelerated test result table
| Color | Melt and become the time limit (min) | Appearance | Content of nanometer silver (μ g) | |
| Embodiment 1 | Milky | 45 | Moist | 50.5 |
| Embodiment 2 | Milky | 47 | Moist | 50.3 |
| Embodiment 3 | Milky | 48 | Moist | 50.3 |
| Embodiment 4 | Milky | 49 | Smooth | 50.1 |
| Embodiment 5 | Milky | 47 | Moist | 50.3 |
| Embodiment 6 | Milky | 50 | Smooth | 49.9 |
Table 5: the 6th month accelerated test result table
| Color | Melt and become the time limit (min) | Appearance | Content of nanometer silver (μ g) | |
| Embodiment 1 | Milky | 43 | Moist | 50.5 |
| Embodiment 2 | Milky | 48 | Smooth | 50.1 |
| Embodiment 3 | Milky | 49 | Smooth | 50.1 |
| Embodiment 4 | Milky | 51 | Smooth | 49.9 |
| Embodiment 5 | Milky | 48 | Moist | 50.2 |
| Embodiment 6 | Micro-yellow | 52 | Indivedual crackle | 49.7 |
Found out by table 2-5, comparing embodiment 1 and embodiment 2-4, the active carbon suppository stability of embodiment 1 (mixed fatty glycerides employing tricaprylin, decanoin, myristin are composite) treatment cervical erosion is obviously better than embodiment 2-4 (in mixed fatty glycerides employing tricaprylin, decanoin, myristin, the two is composite arbitrarily); Comparing embodiment 1 and embodiment 5-6, embodiment 1 (nano-silver water solution preparation adopt sodium carboxymethyl cellulose and Carboxymethyl cellulose sodium composite) the active carbon suppository stability for the treatment of cervical erosion is obviously better than embodiment 5-6 (nano-silver water solution preparation adopts single raw material in sodium carboxymethyl cellulose and Carboxymethyl cellulose sodium).
Claims (2)
1. treat the preparation method of the active carbon suppository of cervical erosion for one kind, it is characterized in that, by 98-102 part water, 0.4-0.6 part nano-silver water solution, 0.8-1.2 part carbomer mix homogeneously, be heated to 65-75 DEG C, add 5-7 part mixed fatty glycerides mix homogeneously, obtain mixed solution; 3-5 part sodium carboxymethyl cellulose, 6-9 part hydroxypropyl cellulose are mixed homogeneously with 78-82 part active carbon, add above-mentioned mixed solution, stir into dough, mould is injected in pressurization, freezing maintenance shape, takes out; At 65-85 DEG C, heat 2-6 hour, then at 105-115 DEG C of heating 0.5-2.5 hour, finally wrap up medical absorbent cotton/gauze.
Described mixed fatty glycerides is mixed by tricaprylin, decanoin, myristin, and the mass ratio of described tricaprylin, decanoin, myristin is (1-3): (1-3): (1-3).
In described nano-silver water solution, the mass concentration of nanometer silver is 85-115 μ g/mL; Described nano-silver water solution is prepared from by following method: by silver nitrate dissolution of solid in water, and preparation obtains solution A, and in solution A, the mass concentration of silver nitrate is 20-40mg/mL; Carboxymethyl cellulose sodium and sodium carboxymethyl cellulose are dissolved in the water, preparation obtains solution B, and in solution B, the mass concentration of Carboxymethyl cellulose sodium is 0.1-0.5mg/mL, and in solution B, the mass concentration of sodium carboxymethyl cellulose is 0.1-0.5mg/mL; Get 0.05-0.2mL solution A to mix with 15-25mL solution B, control its pH value between 7-11, at 20-80 DEG C, react 3-18 hour, obtain described nano-silver water solution.
Described hydroxypropyl cellulose is low-substituted hydroxypropyl cellulose.
2. treat an active carbon suppository for cervical erosion, it is characterized in that, be prepared from by method described in claim 1.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213111A (en) * | 2017-05-08 | 2017-09-29 | 柯泽豪 | A kind of manufacture method for the suppository for treating vaginitis |
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| CN101450385A (en) * | 2008-12-30 | 2009-06-10 | 天津大学 | Nano silver colloid aqueous solution preparation method using sodium cellulose glycolate |
| CN101628123A (en) * | 2009-08-20 | 2010-01-20 | 云南蜀云科技有限公司 | Woman hemostatic absorption plug |
| US20130143922A1 (en) * | 2011-12-02 | 2013-06-06 | Nigel H. Greig | Thio compounds |
| CN104840485A (en) * | 2015-04-23 | 2015-08-19 | 西安巨绅医药科技有限公司 | Active carbon suppository for treating cervical erosion, and preparation method thereof |
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2015
- 2015-12-18 CN CN201510960494.2A patent/CN105434334A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101450385A (en) * | 2008-12-30 | 2009-06-10 | 天津大学 | Nano silver colloid aqueous solution preparation method using sodium cellulose glycolate |
| CN101628123A (en) * | 2009-08-20 | 2010-01-20 | 云南蜀云科技有限公司 | Woman hemostatic absorption plug |
| US20130143922A1 (en) * | 2011-12-02 | 2013-06-06 | Nigel H. Greig | Thio compounds |
| CN104840485A (en) * | 2015-04-23 | 2015-08-19 | 西安巨绅医药科技有限公司 | Active carbon suppository for treating cervical erosion, and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107213111A (en) * | 2017-05-08 | 2017-09-29 | 柯泽豪 | A kind of manufacture method for the suppository for treating vaginitis |
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Application publication date: 20160330 |