CN105342983A - Activated carbon adsorption suppository and preparation method thereof - Google Patents
Activated carbon adsorption suppository and preparation method thereof Download PDFInfo
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- CN105342983A CN105342983A CN201510971805.5A CN201510971805A CN105342983A CN 105342983 A CN105342983 A CN 105342983A CN 201510971805 A CN201510971805 A CN 201510971805A CN 105342983 A CN105342983 A CN 105342983A
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- activated carbon
- carbon adsorption
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/44—Elemental carbon, e.g. charcoal, carbon black
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
Abstract
The invention discloses an activated carbon adsorption suppository and a preparation method thereof. The activated carbon adsorption suppository is prepared from raw materials in parts by weight as follows: 75-85 parts of activated carbon, 0.5-1.5 parts of carbomer, 2-6 parts of modified sodium cellulose, 3-8 parts of fatty acid glyceri, 5-10 parts of glycerin and 95-105 parts of water. The activated carbon adsorption suppository has the characteristics of high adsorption speed, adsorption force and adsorption capacity; through the thickening function of carbomer, the bonding and film formation functions of modified sodium cellulose and the shaping function of fatty acid glyceri, the proportion of diameters of activated carbon fiber holes required for clinic is formed, various pathogenic bacteria and viruses are adsorbed in the fiber holes, the living environment is changed, the pathogenic bacteria and viruses are killed, the effects of anti-inflammation, pain relief, hemostasis, deodorization, disinfection, promotion of cell growth, acceleration of tissue regeneration and disease curing are achieved, and the bacteria cannot generate drug resistance.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of activated carbon adsorption bolt and preparation method thereof.
Background technology
Vaginitis is the general name of the multiple vaginal mucosa inflammatory disease that different pathogeny causes.At normal physiological condition, the histological anatomy of vagina and biochemical characteristics are enough to the invasion and attack defending external microbe.If destroyed, then pathogen can be taken advantage of the occasion and enter, and by means of all factors, causes colpitis.
Vaginitis is the general name of the multiple vaginal mucosa inflammatory disease that different pathogeny causes, and cardinal symptom is abnormal leucorrhoea grow in quantity, with pudendal pruritus, often has vagina burn feeling, pain and sexual anhedonia, sometimes also can occur frequent micturition, dysurea.Vaginitis can be divided into following 4 kinds: (1) nonspecific vaginitis: pudendum, vagina have tenesmus and burning sensation, and vagina epithelium comes off in a large number, and vaginal mucosa is congested, touches a tender spot obviously.Occur time serious that malaise, lower abdomen are uncomfortable, leucorrhea amount is many, in purulence or serosity, leucorrhea outflow stimulates urethral orifice, can occur frequent micturition, dysurea.(2) colpitis mycotica: be also vaginal Candida infection.Outstanding symptom is leucorrhoea grow in quantity, and pudendum, vagina are very itched.Feel restless time serious, painful abnormal, also can have frequent micturition, dysurea, sexual anhedonia.Leucorrhea is white stiff bean dregs sample, and vaginal membranes is treating serious edema caused, and the block thin film of adularescent sheet adheres to, and easily peel off, the erosion of impaired mucosa, can form fester, severe patient can leave over the classical symptom that ecchymosis is primary disease; The leucorrhea of another kind of patient is a large amount of water sample or purulence and without white plates, it is rubescent that vaginal mucosa is medium degree, edema, without serious pruritus and burning sensation, only has pudendum humidity sensation.Some patients also have urinary tract infection symptom and sexual anhedonia; Acute stage leucorrhoea grow in quantity, in white stiff bean dregs sample.(3) trichomonal vaginitis: leucorrhoea grow in quantity and in yellow-white, even band yellow green purulence, is often with foam, has stench, can be mixed with blood when pathological changes is serious; Secondly be the soreness of waist, frequent micturition, dysurea, pruritus vulvae, lower abdomen dull pain.Vaginal mucosa is red and swollen, and have the petechia or strawberry shape projection that are dispersed in, occasional causes dyspareunia.(4) senile vaginitis: leucorrhoea grow in quantity and in yellow fluid sample, when infecting serious, secretions can change purulence into and frowziness, occasionally drips bleeding a little.There are the scorching hot bearing down of vagina, lower abdomen uncomfortable, often occur frequent micturition, dysurea.Vaginal mucosa is rubescent, Mild edema, tenderness, have the point-like be dispersed in or the lamellar ecchymosis differed in size, sometimes with table fester.
Be used for the treatment of colpitic medicament base in the market and be originally divided into two large class, medicine for external use and oral medicines.Show according to investigations, medicine for external use in Beijing, Wuhan, Shanghai, the five metropolitan sale such as Guangzhou and Shenzhen account for more than 70% of gynecological inflammation medication overall market, visible medicine for external use occupies leading position at present.Medicine for external use is mainly divided into lotion class, suppository class and effervescent tablet class.
This research is intended to develop a kind of activated carbon adsorption bolt, can effective anti-bacteria, simultaneously in use safety, effectively, have no side effect and not easily produce drug resistance.
Summary of the invention
For the deficiencies in the prior art, one of technical problem to be solved by this invention is to provide a kind of activated carbon adsorption bolt.
Two of technical problem to be solved by this invention is to provide a kind of preparation method of activated carbon adsorption bolt.
For achieving the above object, the technology used in the present invention solution is:
A kind of activated carbon adsorption bolt, be made up of bolt grain and the medical absorbent cotton/gauze be wrapped in outside bolt grain, described bolt grain is prepared from by the raw material of following weight parts: active carbon 75-85 part, carbomer 0.5-1.5 part, modified cellulose sodium 2-6 part, mixed fatty glycerides 3-8 part, glycerol 5-10 part, water 95-105 part.
Preferably, described mixed fatty glycerides is by myristin, decanoin, 1,2-tetradecanoic acid-3-glyceryl laurate ester mixes, the mass ratio of described myristin, decanoin, 1,2-tetradecanoic acid-3-glyceryl laurate ester is (1-3): (1-3): (1-3).
Preferably, described modified cellulose sodium is one in Carboxymethyl cellulose sodium, sodium carboxymethyl cellulose or its mixture.
Preferably, described modified cellulose sodium is made up of 40-60wt% Carboxymethyl cellulose sodium and 40-60wt% sodium carboxymethyl cellulose.
Present invention also offers the preparation method of above-mentioned activated carbon adsorption bolt, comprise the steps:, by water, carbomer mix homogeneously, to be heated to 60-80 DEG C, to add mixed fatty glycerides mix homogeneously, obtain mixed solution; Modified cellulose sodium, glycerol are mixed homogeneously with active carbon, add above-mentioned mixed solution, stir into dough, mould is injected in pressurization, freezing maintenance shape, takes out; At 60-90 DEG C, heat 2-6 hour, then at 110-120 DEG C of heating 0.5-2.5 hour, obtain bolt grain; Finally wrap up medical absorbent cotton/gauze.
Concrete, in the present invention:
Active carbon, No. CAS: 64365-11-3.
Carbomer, No. CAS: 54182-57-9.
Sodium carboxymethyl cellulose, No. CAS: 9004-32-4.
Carboxymethyl cellulose sodium, No. CAS: 9085-26-1.
Glycerol, No. CAS: 56-81-5.
Myristin, No. CAS: 555-45-3.
Decanoin, No. CAS: 621-71-6.
1,2-tetradecanoic acid-3-glyceryl laurate ester, No. CAS: 115144-38-2.
It is fast that active carbon in a kind of activated carbon adsorption of the present invention bolt has adsorption rate, absorption affinity is strong, the feature that adsorbance is large, at the thickening power of carbomer, the bonding of modified cellulose sodium and filming function, under the figuration effect of mixing-in fat acid glycerol, formed with the ratio of clinical required NACF bore dia, by various malignant bacteria, viruses adsorption is in fiber holes, change its living environment, make it dead, thus reach antiinflammatory, pain relieving, hemostasis, deodorization, sterilizing, Promote cell's growth accelerates tissue regeneration, the effect of cure diseases, and antibacterial can not be made to produce drug resistance.Activated carbon adsorption bolt of the present invention is well-designed according to female pathology structure, adopt built-in suppository type, be placed in the product that intravaginal is used for the treatment of colpitis, be mainly used in the inflammation such as treatment VVC, nonspecific vaginitis, bacterial vaginosis, do not destroy the normal environment of vagina, do not affect the growth of lactobacillus, have no drug resistance, antibacterial stable, has a broad antifungal spectrum, compliance that is easy to use, comfortable, pollution-free, patient is good.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, the following stated, only to preferred embodiment of the present invention, not do other forms of restriction to the present invention, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed to the Equivalent embodiments of equal change.Everyly do not depart from the present invention program's content, any simple modification done following examples according to technical spirit of the present invention or equivalent variations, all drop in protection scope of the present invention.
Medical absorbent cotton/gauze, the article No. adopting Yancheng City Xin Feng medical supplies company limited to produce is the medical absorbent cotton/gauze of YYSB-002.
Embodiment 1
Bolt grain raw material: active carbon 80g, carbomer 1g, Carboxymethyl cellulose sodium 4g, mixed fatty glycerides 6g, glycerol 7g, deionized water 100g.
Described mixed fatty glycerides is mixed by 2g myristin, 2g decanoin, 2g1,2-tetradecanoic acid-3-glyceryl laurate ester.
Prepared by activated carbon adsorption bolt:
Under rotating speed 100r/min stirring condition, in deionized water, add carbomer, mix homogeneously, be heated to 70 DEG C, add mixed fatty glycerides mix homogeneously, obtain mixed solution; Carboxymethyl cellulose sodium, glycerol are mixed homogeneously with active carbon, add above-mentioned mixed solution, stir into dough, mould is injected in pressurization, freezing maintenance shape, takes out; Heat 4 hours at 80 DEG C, then 115 DEG C of heating 1 hour, obtain bolt grain; Finally wrap up described bolt grain with medical absorbent cotton/gauze, refill two aluminum composite membrane bag sealing, through cobalt-60 sterilization, obtain the activated carbon adsorption bolt of embodiment 1,1.5 grams every.
Embodiment 2
Prepare activated carbon adsorption bolt by embodiment 1 proportioning raw materials and method, difference is only: described mixed fatty glycerides is mixed by 3g myristin, 3g decanoin.Obtain the activated carbon adsorption bolt of embodiment 2,1.5 grams every.
Embodiment 3
Prepare activated carbon adsorption bolt by embodiment 1 proportioning raw materials and method, difference is only: described mixed fatty glycerides is mixed by 3g myristin, 3g1,2-tetradecanoic acid-3-glyceryl laurate ester.Obtain the activated carbon adsorption bolt of embodiment 3,1.5 grams every.
Embodiment 4
Prepare activated carbon adsorption bolt by embodiment 1 proportioning raw materials and method, difference is only: described mixed fatty glycerides is mixed by 3g decanoin, 3g1,2-tetradecanoic acid-3-glyceryl laurate ester.Obtain the activated carbon adsorption bolt of embodiment 4,1.5 grams every.
Embodiment 5
Bolt grain raw material: active carbon 80g, carbomer 1g, sodium carboxymethyl cellulose 4g, mixed fatty glycerides 6g, glycerol 7g, deionized water 100g.
Described mixed fatty glycerides is mixed by 2g myristin, 2g decanoin, 2g1,2-tetradecanoic acid-3-glyceryl laurate ester.
Prepared by activated carbon adsorption bolt:
Under rotating speed 100r/min stirring condition, in deionized water, add carbomer, mix homogeneously, be heated to 70 DEG C, add mixed fatty glycerides mix homogeneously, obtain mixed solution; Sodium carboxymethyl cellulose, glycerol are mixed homogeneously with active carbon, add above-mentioned mixed solution, stir into dough, mould is injected in pressurization, freezing maintenance shape, takes out; Heat 4 hours at 80 DEG C, then 115 DEG C of heating 1 hour, obtain bolt grain; Finally wrap up gauze, the two aluminum composite membrane bag sealing of dress, through cobalt-60 sterilization, obtains the activated carbon adsorption bolt of embodiment 5,1.5 grams every.
Embodiment 6
Bolt grain raw material: active carbon 80g, carbomer 1g, sodium carboxymethyl cellulose 2g, Carboxymethyl cellulose sodium 2g, mixed fatty glycerides 6g, glycerol 7g, deionized water 100g.
Described mixed fatty glycerides is mixed by 2g myristin, 2g decanoin, 2g1,2-tetradecanoic acid-3-glyceryl laurate ester.
Prepared by activated carbon adsorption bolt:
Under rotating speed 100r/min stirring condition, in deionized water, add carbomer, mix homogeneously, be heated to 70 DEG C, add mixed fatty glycerides mix homogeneously, obtain mixed solution; Sodium carboxymethyl cellulose, Carboxymethyl cellulose sodium, glycerol are mixed homogeneously with active carbon, add above-mentioned mixed solution, stir into dough, mould is injected in pressurization, freezing maintenance shape, takes out; Heat 4 hours at 80 DEG C, then 115 DEG C of heating 1 hour, obtain bolt grain; Finally wrap up gauze, the two aluminum composite membrane bag sealing of dress, through cobalt-60 sterilization, obtains the activated carbon adsorption bolt of embodiment 6,1.5 grams every.
Test case 1
The activated carbon adsorption bolt obtained to embodiment 1-6 carries out therapeutic effect test, select hospital outpatient age 20-60 year cervical erosion III degree of patient 300, be divided into 6 groups at random, often organize 50, use the activated carbon adsorption bolt that embodiment 1-6 is obtained respectively, every day 1, be positioned over vagina deep before sleeping 8 hours, within 14 days, detect conditions of patients improved condition afterwards.Concrete data are in table 1.
Table 1: conditions of patients tables of data
Found out by table 1, comparing embodiment 1 and embodiment 2-4, (mixed fatty glycerides adopts myristin, decanoin, 1 to embodiment 1,2-tetradecanoic acid-3-glyceryl laurate ester is composite) therapeutic effect is obviously better than embodiment 2-4 (mixed fatty glycerides adopts myristin, decanoin, the two is composite arbitrarily in 1,2-tetradecanoic acid-3-glyceryl laurate ester); Comparing embodiment 1 and embodiment 5-6, embodiment 1 (modified cellulose sodium adopt sodium carboxymethyl cellulose and Carboxymethyl cellulose sodium composite) therapeutic effect is obviously better than embodiment 5-6 (modified cellulose sodium adopts single raw material in sodium carboxymethyl cellulose and Carboxymethyl cellulose sodium).
Test case 2
The change of activated carbon adsorption bolt quality index under accelerated test condition that testing example 1-6 obtains.
The activated carbon adsorption bolt that embodiment 1-6 is obtained carries out accelerated test in equal conditions, temperature is 40 ± 2 DEG C, place 6 months in the constant temperature humidity chamber of relative humidity 75 ± 5%, sample respectively once 1st month, the 2nd month, the 3rd month, the 6th the end of month at duration of test, by regulation investigate preparation color, melt become the time limit, afterbody particle, content of nanometer silver, stability result is in Table 2-5.
Table 2: the 1st month accelerated test stability result table
Table 3: the 2nd month accelerated test result table
Table 4: the 3rd month accelerated test result table
Table 5: the 6th month accelerated test result table
Found out by table 2-5, comparing embodiment 1 and embodiment 2-4, (mixed fatty glycerides adopts myristin, decanoin, 1 to embodiment 1,2-tetradecanoic acid-3-glyceryl laurate ester is composite) activated carbon adsorption bolt stability is obviously better than embodiment 2-4 (mixed fatty glycerides adopts myristin, decanoin, the two is composite arbitrarily in 1,2-tetradecanoic acid-3-glyceryl laurate ester); Comparing embodiment 1 and embodiment 5-6, embodiment 1 (modified cellulose sodium adopt sodium carboxymethyl cellulose and Carboxymethyl cellulose sodium composite) activated carbon adsorption bolt stability is obviously better than embodiment 5-6 (modified cellulose sodium adopts single raw material in sodium carboxymethyl cellulose and Carboxymethyl cellulose sodium).
It is fast that active carbon in a kind of activated carbon adsorption of the present invention bolt has adsorption rate, absorption affinity is strong, the feature that adsorbance is large, at the thickening power of carbomer, the bonding of modified cellulose sodium and filming function, under the figuration effect of mixing-in fat acid glycerol, formed with the ratio of clinical required NACF bore dia, by various malignant bacteria, viruses adsorption is in fiber holes, change its living environment, make it dead, thus reach antiinflammatory, pain relieving, hemostasis, deodorization, sterilizing, Promote cell's growth accelerates tissue regeneration, the effect of cure diseases, and antibacterial can not be made to produce drug resistance.Activated carbon adsorption bolt of the present invention is well-designed according to female pathology structure, adopt built-in suppository type, be placed in the product that intravaginal is used for the treatment of colpitis, be mainly used in the inflammation such as treatment VVC, nonspecific vaginitis, bacterial vaginosis, do not destroy the normal environment of vagina, do not affect the growth of lactobacillus, have no drug resistance, antibacterial stable, has a broad antifungal spectrum, compliance that is easy to use, comfortable, pollution-free, patient is good.
Claims (6)
1. an activated carbon adsorption bolt, be made up of bolt grain and the medical absorbent cotton/gauze be wrapped in outside described bolt grain, it is characterized in that, described bolt grain is prepared from by the raw material of following weight parts: active carbon 75-85 part, carbomer 0.5-1.5 part, modified cellulose sodium 2-6 part, mixed fatty glycerides 3-8 part, glycerol 5-10 part, water 95-105 part.
2. activated carbon adsorption bolt as claimed in claim 1, it is characterized in that, described mixed fatty glycerides is by myristin, decanoin, 1,2-tetradecanoic acid-3-glyceryl laurate ester mixes, the mass ratio of described myristin, decanoin, 1,2-tetradecanoic acid-3-glyceryl laurate ester is (1-3): (1-3): (1-3).
3. activated carbon adsorption bolt as claimed in claim 1 or 2, is characterized in that, described modified cellulose sodium is one in Carboxymethyl cellulose sodium, sodium carboxymethyl cellulose or its mixture.
4. activated carbon adsorption bolt as claimed in claim 3, it is characterized in that, described modified cellulose sodium is Carboxymethyl cellulose sodium.
5. activated carbon adsorption bolt as claimed in claim 1 or 2, it is characterized in that, described modified cellulose sodium is made up of 40-60wt% Carboxymethyl cellulose sodium and 40-60wt% sodium carboxymethyl cellulose.
6. the preparation method of the activated carbon adsorption bolt according to any one of claim 1-5, comprises the steps:, by water, carbomer mix homogeneously, to be heated to 60-80 DEG C, to add mixed fatty glycerides mix homogeneously, obtain mixed solution; Modified cellulose sodium, glycerol are mixed homogeneously with active carbon, add above-mentioned mixed solution, stir into dough, mould is injected in pressurization, freezing maintenance shape, takes out; At 60-90 DEG C, heat 2-6 hour, then at 110-120 DEG C of heating 0.5-2.5 hour, obtain bolt grain; Finally wrap up medical absorbent cotton/gauze.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105832767A (en) * | 2016-04-12 | 2016-08-10 | 李璐 | Applications of active carbon nanoparticles and graphene in resisting HPV virus |
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