CN105412731A - 一种治疗皮肤瘙痒症的药膏及其制备方法 - Google Patents
一种治疗皮肤瘙痒症的药膏及其制备方法 Download PDFInfo
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Abstract
本发明提供一种治疗皮肤瘙痒症的药膏及其制备方法,涉及中药技术领域,所述的治疗皮肤瘙痒症的药膏是由下述原料药制备而成的外用药剂:所述原料药为:黄柏、土茯苓、乌蛇肉、蚤休、蝉蜕、生首乌、生大黄、苍术、青黛、金银花、白鲜皮、益母草、黄芪、山茶油、洋甘菊精油,所述辅料为:对羟基苯甲酸丙酯、聚氧乙烯脂肪酸酯、吡硫鎓锌、甘草酸铵、二乙醇酰胺、水杨酸,本发明能够较好地治疗由过敏性皮炎、湿疹、荨麻疹、皮肤癣等引起的皮肤瘙痒症,疗效显著,见效快,且能标本兼治,经临床验证没有任何毒副作用,制备工艺简单易操作、原料易得、无不良反应。
Description
技术领域
本发明涉及中药领域,具体涉及一种治疗皮肤瘙痒症的药膏及其制备方法。
背景技术
皮肤瘙痒是临床上常见的皮肤病之一,尤其多见于老年人。其特征为以瘙痒为主,而无原发性损害。临床上可分为限局性和全身性两种。瘙痒症是一种自觉瘙痒而临床上无原发损害的皮肤病。瘙痒症的病因尚不明了,多认为与某些疾病有关,如糖尿病、肝病、肾病等;同时还与一些外界因素刺激有、关,如寒冷、温热、化纤织物等。皮肤瘙痒症也可能是一种皮肤神经官能症疾患。临床上将只有皮肤瘙痒而无原发性皮肤损害者称之为瘙痒症,属中医“痒风”的范畴。皮肤瘙痒分普通型和过敏型。可全身发生,尤以面、背和四肢为多。普通型皮肤瘙痒一般是皮肤太干燥造成的,或者是有细菌真菌引起。
皮肤作为人体上与外界接触面积最大的部分,受到体内和各种体外条件和环境的影响,极易发生各种皮肤瘙痒、溃烂、皮癣等各种各样的皮肤症状,为此,人们开发出了各种各样的皮肤类药物来适应和治疗各种不同的皮肤症状,目前,用于治疗皮肤瘙痒的外用药物大多以激素类药物为主,例如:皮炎平、无极膏、派瑞松、地塞米松类等,这种激素类药物在开始使用的时候可能效果很好,一涂之后能使某些皮肤症状很快消失,可是这种药物在长期使用一段时间后很有可能会发生涂药部位皮肤异常,如继发感染、毛囊炎、毛细血管扩张、激素性皮炎、皮肤萎缩、色素沉着等副作用,女性还可能出现毛发增多等严重反应,并且停药后容易复发,效果不够理想,这类药物中含有化学合成成分的西药占多数,也有部分纯中药成分的膏状药物,含有西药成分的药物一般见效快,但有一定的毒副作用,有时还会在涂抹部位留下痕迹,对一些皮肤敏感或特定的人群如幼儿、老人、女性等并不完全适用,纯中药成分的药物副作用小,但一般疗效慢,而且目前的中药产业化和标准化的困境,这类药物价格比较贵,使用成本比较高,使一般的皮肤病治疗花费加大。给患者带来很大经济和精神上的压力。
发明内容
(一)解决的技术问题
针对现有技术不足,本发明提供一种治疗皮肤瘙痒症的药膏及其制备方法,采用中西药结合的方法制备了治疗皮肤瘙痒症的药膏,原料易得,而且价格低廉,本发明制备方法步骤简单,无需复杂的设备和场地要求,操作简单,本制品无毒无副作用,使用过程中对皮肤不产生刺激,感觉良好,本品易制易得,疗效显著,成本低廉,适合用于治疗皮肤瘙痒、皮癣等皮肤科疾病。
(二)技术方案
为实现以上目的,本发明通过以下技术方案予以实现:
一种治疗皮肤瘙痒症的药膏,所述药膏是由下述重量份的原料药制备而成的外用药剂:所述原料药及其重量份为:黄柏60-85份、土茯苓42-62份、乌蛇肉13-22份、蚤休18-25份、蝉蜕18-25份、生首乌63-83份、生大黄63-83份、苍术50-75份、青黛26-40份、金银花63-85份、白鲜皮68-86份、益母草60-85份、黄芪68-86份、山茶油10-25份、洋甘菊精油10-25份,所述辅料及其重量份为:对羟基苯甲酸丙酯16-27份、聚氧乙烯脂肪酸酯15-28份、吡硫鎓锌12-19份、甘草酸铵10-25份、二乙醇酰胺10-25份、水杨酸12-22份。
优选的,所述药膏是由下述重量份的原料药制备而成的外用药剂:所述原料药及其重量份为:黄柏65-80份、土茯苓45-60份、乌蛇肉15-20份、蚤休20-25份、蝉蜕20-25份、生首乌67-80份、生大黄68-79份、苍术55-70份、青黛30-39份、金银花65-82份、白鲜皮75-82份、益母草65-83份、黄芪72-85份、山茶油12-21份、洋甘菊精油13-20份,所述辅料及其重量份为:对羟基苯甲酸丙酯18-25份、聚氧乙烯脂肪酸酯18-25份、吡硫鎓锌15-18份、甘草酸铵15-23份、二乙醇酰胺15-24份、水杨酸15-20份。
优选的,所述药膏是由下述重量份的原料药制备而成的外用药剂:所述原料药及其重量份为:黄柏68-76份、土茯苓50-58份、乌蛇肉17-19份、蚤休21-24份、蝉蜕21-23份、生首乌70-77份、生大黄70-76份、苍术60-67份、青黛32-36份、金银花70-78份、白鲜皮79-81份、益母草70-80份、黄芪76-82份、山茶油15-20份、洋甘菊精油15-19份,所述辅料及其重量份为:对羟基苯甲酸丙酯20-24份、聚氧乙烯脂肪酸酯20-23份、吡硫鎓锌16-17份、甘草酸铵18-20份、二乙醇酰胺18-22份、水杨酸16-18份。
优选的,所述药膏是由下述重量份的原料药制备而成的外用药剂:所述原料药及其重量份为:黄柏73份、土茯苓52份、乌蛇肉17份、蚤休21份、蝉蜕21份、生首乌73份、生大黄73份、苍术63份、青黛33份、金银花74份、白鲜皮77份、益母草73份、黄芪78份、山茶油17份、洋甘菊精油18份,所述辅料及其重量份为:对羟基苯甲酸丙酯21份、聚氧乙烯脂肪酸酯22份、吡硫鎓锌15份、甘草酸铵17份、二乙醇酰胺16份、水杨酸17份。
一种治疗皮肤瘙痒症的药膏的制备方法,,包括以下步骤:
S1、称取重量份的烘干后的乌蛇肉、蚤休和蝉蜕,混合投入粉碎剂中粉碎,过80-100目筛,得粉状混合物备用;
S2、称取重量份的干净的黄柏、土茯苓、生首乌、生大黄、苍术、青黛、金银花、白鲜皮、益母草和黄芪,混合后于90-110℃煎煮2-4h,过滤,得到中药混合提取液,备用;
S3、将步骤S1中制得的粉状混合物加入步骤S2中制得的中药混合提取液中,加入山茶油和洋甘菊精油,搅拌均匀,再加入辅料对羟基苯甲酸丙酯、聚氧乙烯脂肪酸酯、吡硫鎓锌、甘草酸铵、二乙醇酰胺和水杨酸,搅拌45-60min,即可。
优选的,步骤S1所述过筛为过100目筛。
(三)有益效果
本发明提供一种治疗皮肤瘙痒症的药膏及其制备方法,本发明配方合理,能够较好地治疗由过敏性皮炎、湿疹、荨麻疹、皮肤癣等引起的皮肤瘙痒症,疗效显著,见效快,且能标本兼治,经临床验证没有任何毒副作用,治愈率高达93%以上,治愈后不易复发;本发明治疗皮肤瘙痒症的药膏具有祛风止痒、养血润肤、消疮肿、祛风湿、清热解毒之功效,该药膏可长期使用,并且同时具有预防作用;制备工艺简单易操作、原料易得、无不良反应。
具体实施方式
为使本发明实施例的目的、技术方案和优点更加清楚,下面将结合本发明实施例,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1:
本实施例治疗皮肤瘙痒症的药膏,由下述重量份的原料药制备而成的外用药剂:所用原料药及其重量份为:黄柏60份、土茯苓42份、乌蛇肉13份、蚤休18份、蝉蜕18份、生首乌63份、生大黄63份、苍术50份、青黛26份、金银花63份、白鲜皮68份、益母草60份、黄芪68份、山茶油10份、洋甘菊精油10份,所用辅料及其重量份为:对羟基苯甲酸丙酯16份、聚氧乙烯脂肪酸酯15份、吡硫鎓锌12份、甘草酸铵10份、二乙醇酰胺10份、水杨酸12份。
按照本实施例原料和辅料重量份,制备方法包括以下步骤:
S1、称取重量份的烘干后的乌蛇肉、蚤休和蝉蜕,混合投入粉碎剂中粉碎,过80-100目筛,得粉状混合物备用;
S2、称取重量份的干净的黄柏、土茯苓、生首乌、生大黄、苍术、青黛、金银花、白鲜皮、益母草和黄芪,混合后于90-110℃煎煮2-4h,过滤,得到中药混合提取液,备用;
S3、将步骤S1中制得的粉状混合物加入步骤S2中制得的中药混合提取液中,加入山茶油和洋甘菊精油,搅拌均匀,再加入辅料对羟基苯甲酸丙酯、聚氧乙烯脂肪酸酯、吡硫鎓锌、甘草酸铵、二乙醇酰胺和水杨酸,搅拌45-60min,即可。
实施例2:
本实施例治疗皮肤瘙痒症的药膏,由下述重量份的原料药制备而成的外用药剂:所用原料药及其重量份为:黄柏85份、土茯苓62份、乌蛇肉22份、蚤休25份、蝉蜕25份、生首乌83份、生大黄83份、苍术75份、青黛40份、金银花85份、白鲜皮86份、益母草85份、黄芪86份、山茶油25份、洋甘菊精油25份,所用辅料及其重量份为:对羟基苯甲酸丙酯27份、聚氧乙烯脂肪酸酯28份、吡硫鎓锌19份、甘草酸铵25份、二乙醇酰胺25份、水杨酸22份。
按照本实施例原料和辅料重量份,制备方法包括以下步骤:
S1、称取重量份的烘干后的乌蛇肉、蚤休和蝉蜕,混合投入粉碎剂中粉碎,过80-100目筛,得粉状混合物备用;
S2、称取重量份的干净的黄柏、土茯苓、生首乌、生大黄、苍术、青黛、金银花、白鲜皮、益母草和黄芪,混合后于90-110℃煎煮2-4h,过滤,得到中药混合提取液,备用;
S3、将步骤S1中制得的粉状混合物加入步骤S2中制得的中药混合提取液中,加入山茶油和洋甘菊精油,搅拌均匀,再加入辅料对羟基苯甲酸丙酯、聚氧乙烯脂肪酸酯、吡硫鎓锌、甘草酸铵、二乙醇酰胺和水杨酸,搅拌45-60min,即可。
实施例3:
本实施例治疗皮肤瘙痒症的药膏,由下述重量份的原料药制备而成的外用药剂:所用原料药及其重量份为:黄柏73份、土茯苓52份、乌蛇肉17份、蚤休21份、蝉蜕21份、生首乌73份、生大黄73份、苍术63份、青黛33份、金银花74份、白鲜皮77份、益母草73份、黄芪78份、山茶油17份、洋甘菊精油18份,所用辅料及其重量份为:对羟基苯甲酸丙酯21份、聚氧乙烯脂肪酸酯22份、吡硫鎓锌15份、甘草酸铵17份、二乙醇酰胺16份、水杨酸17份。
按照本实施例原料和辅料重量份,制备方法同实施例1。
实施例4:
本实施例治疗皮肤瘙痒症的药膏,由下述重量份的原料药制备而成的外用药剂:所用原料药及其重量份为:黄柏65份、土茯苓45份、乌蛇肉15份、蚤休20份、蝉蜕20份、生首乌67份、生大黄68份、苍术55份、青黛30份、金银花65份、白鲜皮75份、益母草65份、黄芪72份、山茶油12份、洋甘菊精油13份,所用辅料及其重量份为:对羟基苯甲酸丙酯18份、聚氧乙烯脂肪酸酯18份、吡硫鎓锌15份、甘草酸铵15份、二乙醇酰胺15份、水杨酸15份。
按照本实施例原料和辅料重量份,制备方法同实施例1。
实施例5:
本实施例治疗皮肤瘙痒症的药膏,由下述重量份的原料药制备而成的外用药剂:所用原料药及其重量份为:黄柏80份、土茯苓60份、乌蛇肉20份、蚤休25份、蝉蜕25份、生首乌80份、生大黄79份、苍术70份、青黛39份、金银花82份、白鲜皮82份、益母草83份、黄芪85份、山茶油21份、洋甘菊精油20份,所用辅料及其重量份为:对羟基苯甲酸丙酯25份、聚氧乙烯脂肪酸酯25份、吡硫鎓锌18份、甘草酸铵23份、二乙醇酰胺24份、水杨酸20份。
按照本实施例原料和辅料重量份,制备方法同实施例1。
实施例6:
本实施例治疗皮肤瘙痒症的药膏,由下述重量份的原料药制备而成的外用药剂:所用原料药及其重量份为:黄柏68份、土茯苓50份、乌蛇肉17份、蚤休21份、蝉蜕21份、生首乌70份、生大黄70份、苍术60份、青黛32份、金银花70份、白鲜皮79份、益母草70份、黄芪76份、山茶油15份、洋甘菊精油15份,所用辅料及其重量份为:对羟基苯甲酸丙酯20份、聚氧乙烯脂肪酸酯20份、吡硫鎓锌16份、甘草酸铵18份、二乙醇酰胺18份、水杨酸16份。
按照本实施例原料和辅料重量份,制备方法同实施例1。
实施例7:
本实施例治疗皮肤瘙痒症的药膏,由下述重量份的原料药制备而成的外用药剂:所用原料药及其重量份为:黄柏76份、土茯苓58份、乌蛇肉19份、蚤休24份、蝉蜕23份、生首乌77份、生大黄76份、苍术67份、青黛36份、金银花78份、白鲜皮81份、益母草80份、黄芪82份、山茶油20份、洋甘菊精油19份,所用辅料及其重量份为:对羟基苯甲酸丙酯24份、聚氧乙烯脂肪酸酯23份、吡硫鎓锌17份、甘草酸铵20份、二乙醇酰胺22份、水杨酸18份。
按照本实施例原料和辅料重量份,制备方法同实施例1。
需要说明的是,在本文中,诸如第一和第二等之类的关系术语仅仅用来将一个实体或者操作与另一个实体或操作区分开来,而不一定要求或者暗示这些实体或操作之间存在任何这种实际的关系或者顺序。而且,术语“包括”、“包含”或者其任何其他变体意在涵盖非排他性的包含,从而使得包括一系列要素的过程、方法、物品或者设备不仅包括那些要素,而且还包括没有明确列出的其他要素,或者是还包括为这种过程、方法、物品或者设备所固有的要素。在没有更多限制的情况下,由语句“包括一个……”限定的要素,并不排除在包括所述要素的过程、方法、物品或者设备中还存在另外的相同要素。
以上实施例仅用以说明本发明的技术方案,而非对其限制,尽管参照前述实施例对本发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离本发明各实施例技术方案的精神和范围。
Claims (6)
1.一种治疗皮肤瘙痒症的药膏,其特征在于,所述药膏是由下述重量份的原料药制备而成的外用药剂:所述原料药及其重量份为:黄柏60-85份、土茯苓42-62份、乌蛇肉13-22份、蚤休18-25份、蝉蜕18-25份、生首乌63-83份、生大黄63-83份、苍术50-75份、青黛26-40份、金银花63-85份、白鲜皮68-86份、益母草60-85份、黄芪68-86份、山茶油10-25份、洋甘菊精油10-25份,所述辅料及其重量份为:对羟基苯甲酸丙酯16-27份、聚氧乙烯脂肪酸酯15-28份、吡硫鎓锌12-19份、甘草酸铵10-25份、二乙醇酰胺10-25份、水杨酸12-22份。
2.根据权利要求1所述治疗皮肤瘙痒症的药膏,其特征在于,所述药膏是由下述重量份的原料药制备而成的外用药剂:所述原料药及其重量份为:黄柏65-80份、土茯苓45-60份、乌蛇肉15-20份、蚤休20-25份、蝉蜕20-25份、生首乌67-80份、生大黄68-79份、苍术55-70份、青黛30-39份、金银花65-82份、白鲜皮75-82份、益母草65-83份、黄芪72-85份、山茶油12-21份、洋甘菊精油13-20份,所述辅料及其重量份为:对羟基苯甲酸丙酯18-25份、聚氧乙烯脂肪酸酯18-25份、吡硫鎓锌15-18份、甘草酸铵15-23份、二乙醇酰胺15-24份、水杨酸15-20份。
3.根据权利要求1所述治疗皮肤瘙痒症的药膏,其特征在于,所述药膏是由下述重量份的原料药制备而成的外用药剂:所述原料药及其重量份为:黄柏68-76份、土茯苓50-58份、乌蛇肉17-19份、蚤休21-24份、蝉蜕21-23份、生首乌70-77份、生大黄70-76份、苍术60-67份、青黛32-36份、金银花70-78份、白鲜皮79-81份、益母草70-80份、黄芪76-82份、山茶油15-20份、洋甘菊精油15-19份,所述辅料及其重量份为:对羟基苯甲酸丙酯20-24份、聚氧乙烯脂肪酸酯20-23份、吡硫鎓锌16-17份、甘草酸铵18-20份、二乙醇酰胺18-22份、水杨酸16-18份。
4.根据权利要求1所述治疗皮肤瘙痒症的药膏,其特征在于,所述药膏是由下述重量份的原料药制备而成的外用药剂:所述原料药及其重量份为:黄柏73份、土茯苓52份、乌蛇肉17份、蚤休21份、蝉蜕21份、生首乌73份、生大黄73份、苍术63份、青黛33份、金银花74份、白鲜皮77份、益母草73份、黄芪78份、山茶油17份、洋甘菊精油18份,所述辅料及其重量份为:对羟基苯甲酸丙酯21份、聚氧乙烯脂肪酸酯22份、吡硫鎓锌15份、甘草酸铵17份、二乙醇酰胺16份、水杨酸17份。
5.一种如权利1-4任一所述治疗皮肤瘙痒症的药膏的制备方法,其特征在于,包括以下步骤:
S1、称取重量份的烘干后的乌蛇肉、蚤休和蝉蜕,混合投入粉碎剂中粉碎,过80-100目筛,得粉状混合物备用;
S2、称取重量份的干净的黄柏、土茯苓、生首乌、生大黄、苍术、青黛、金银花、白鲜皮、益母草和黄芪,混合后于90-110℃煎煮2-4h,过滤,得到中药混合提取液,备用;
S3、将步骤S1中制得的粉状混合物加入步骤S2中制得的中药混合提取液中,加入山茶油和洋甘菊精油,搅拌均匀,再加入辅料对羟基苯甲酸丙酯、聚氧乙烯脂肪酸酯、吡硫鎓锌、甘草酸铵、二乙醇酰胺和水杨酸,搅拌45-60min,即可。
6.根据权利要求5所述治疗皮肤瘙痒症的药膏的制备方法,其特征在于,步骤S1所述过筛为过100目筛。
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